LOCUS       c00248_NZ_PEMR..        8113 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_PEMR01000310.1 Thermus scotoductus strain 6_S6
            NODE_96_length_8113_cov_60.8874_ID_191, whole genome shotgun
            sequence.
ACCESSION   NZ_PEMR01000310
VERSION     NZ_PEMR01000310
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:09:10
            Original ID  :: NZ_PEMR01000310.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8113
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8113
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2372:6730]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2373..6730
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..8113
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8113
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03882))"
                     /tool="antismash"
     CDS             2..574
                     /locus_tag="ctg248_1"
                     /transl_table=11
                     /translation="PQAPRVHPVVIPDLPSLSGLLVRPGDRVEEGEPLARYTDPAPLED
                     LEAQAQAKREEAQRLEGEIRALEERFRAEREALERERARAREERDRLRYLVSQGAEPAL
                     RLAEAEGRLEEAEGRLRKLVLDYTTQRARLEESAREARLEAARLDRRREREAERQLVRA
                     PVSGRVAEVKVRDLTPKGVTVEVVLVQ"
     CDS             749..1270
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 51.9; E-value:
                     9.7e-16)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg248_2"
                     /transl_table=11
                     /translation="MTCHSGVETLRLHGLALLASAQLSRPVHLVLDAPWGFTLWGLAQL
                     PRPCLIVTQCPSPHYLRDLMDLQPEGILATSANPEDILRGLQAVAQDQPFHKLPPLGPE
                     ILTVRERQVMRLVALGLSDAEIARRLSVSKRTVYNWVSSLQDKLGLENRVELALYYLGL
                     LPHCRGWRGM"
     PFAM_domain     1061..1225
                     /aSDomain="GerE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00196.21"
                     /description="Bacterial regulatory proteins, luxR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_2_0001"
                     /evalue="1.40E-15"
                     /label="ctg248_2"
                     /locus_tag="ctg248_2"
                     /protein_end="159"
                     /protein_start="104"
                     /score="56.7"
                     /tool="antismash"
                     /translation="ILTVRERQVMRLVALGLSDAEIARRLSVSKRTVYNWVSSLQDKLG
                     LENRVELALY"
     CDS             1378..1575
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg248_3"
                     /transl_table=11
                     /translation="MAVASLNPFDLASLDIRTSAAMDAGTVSPQSTLVCATIVISFRSN
                     LCCVVTITLLACPRTEELPA"
     CDS_motif       1378..1467
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAVASLNPFDLASLDIRTSAAMDAGTVSPQ"
                     /locus_tag="ctg248_3_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1468..1575
                     /prepeptide="core"
                     /locus_tag="ctg248_3_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-6.90"
                     /molecular_weight="3594.3"
                     /monoisotopic_mass="3591.9"
                     /core_sequence="STLVCATIVISFRSNLCCVVTITLLACPRTEELPA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAVASLNPFDLASLDIRTSAAMDAGTVSPQ"
                     /leader_location="[1377:1467](+)"
                     /alternative_weights="3612.3"
                     /alternative_weights="3630.3"
                     /alternative_weights="3648.4"
                     /alternative_weights="3666.4"
     CDS             1633..2376
                     /locus_tag="ctg248_4"
                     /transl_table=11
                     /translation="MNATRGNPYFLEAKYDLLQQLRIPGQFIGTPLGGVGAYGLLLLMG
                     RDLGGLGEEFLVRFAALGVMNVGLLAIGLGAASERAYGWIRLRQVAPMPPLAYFLGKVS
                     TGAVMAALTALGVLLVELVFGAVSWPYYAWVSLTLALVLGSLPFTALGLAAAYLVRPNS
                     AQPLIVYTAAFVLFPVFMPLLRLPEWIQTIFSYLPSALFIDLALGAVGLASPSLPSFVL
                     LAAYTIAFLLLAAWLFGRDEGSTFG"
     PFAM_domain     1807..2340
                     /aSDomain="ABC2_membrane_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12698.9"
                     /description="ABC-2 family transporter protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_4_0002"
                     /evalue="3.90E-11"
                     /label="ctg248_4"
                     /locus_tag="ctg248_4"
                     /protein_end="236"
                     /protein_start="58"
                     /score="42.8"
                     /tool="antismash"
                     /translation="FAALGVMNVGLLAIGLGAASERAYGWIRLRQVAPMPPLAYFLGKV
                     STGAVMAALTALGVLLVELVFGAVSWPYYAWVSLTLALVLGSLPFTALGLAAAYLVRPN
                     SAQPLIVYTAAFVLFPVFMPLLRLPEWIQTIFSYLPSALFIDLALGAVGLASPSLPSFV
                     LLAAYTIAFLLLAAW"
     CDS             2373..5450
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     674; E-value: 5.2e-204)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg248_5"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-155, bitscore:
                     507.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.4e-37, bitscore:
                     117.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-14,
                     bitscore: 43.8, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIWGCTVQGAMVRVPLFPVEWYLQALSAPDGLADYLLEILREPAF
                     MEALWLASPSLAREAERWRDGEKAPGTSQLLGLLRYLIRATTRPTPFGLFAGVAFVPIE
                     EQTRLRLAGLGSHQKRARLDYGQALAFVQSLERDPALRSELYVYANPALLRWYSRIRVT
                     CRDGYGRGQDPGQAWIRLTDPVQVILEYAARPVQYGDLIRRLQERYPQSSEVDIDLFLL
                     KLLDESVLLSTLRPPLTEMEPHSYLARMIPPTSPPSETTERVLQASRLIQEINATKIGE
                     GTKLLKALYEEFGLQQGDRQHLIQMDLRLGLEEASLSHQVIAPLQKAARLLAQLFGTRS
                     PAEASLRQYAQAFLERYGLREVPLLELLDEELGLGPPPGYHNPPPRRSWARSALPEPPE
                     LREIYHILAEQVSLCLREGRLDLDLEDVALPQSELEVALPPAVEVFFSIHGEGETPTLV
                     ISPAGFVTSRGGVFGRFAYIDERFHQMLRALAEEEVHRYPDYAFAEVVYSDRVGHHTNV
                     ALHPSLYPYQIAVGVAPSVPFERQIPLSELMVGVDGQRFYVYSPSLDRIVLPRAPHVLN
                     PQLAPNSVRFLREVGEQGLAVVPTWQWGPLSTLPFLPRVRLGQVVLAPARWRLPRPLPR
                     DLGALDRWRAQWQVPRYVYIGSHDNRLLLDLDHPACFELLRREAPEYVEEAPDPHSAWV
                     SGGSGHHMAEYVLRLPLGSAGESYPQRAARSVQSLDPVRRMRFPGQRVIYLKLYGPATF
                     QNDILFALHQFLKEHGSPNWFFVRYQDPDDHLRVRIFGKEGELGEFLSRFSREAHRYAE
                     NGFLLRWATDTYEPEFERYGGEAGLAVCEEIFCVETRALLELFALKPPLPLRELALFSV
                     DGLLEGLGMSAKDRYHLYHKLVEVHLKDLGQAGKEKIQQWKREFGQARSRLWQVMSWFR
                     GGTVGSGPPADQPAKWYGDFKTQLGPLGRALQELERRHMLLYPIGHVAASLIHMNANRL
                     GLFQDEEHRLTYFLYALYDGFRHYIPATLPLTWEEI"
     PFAM_domain     2496..4397
                     /aSDomain="Lant_dehydr_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04738.15"
                     /description="Lantibiotic dehydratase, N terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_5_0003"
                     /evalue="1.70E-149"
                     /label="ctg248_5"
                     /locus_tag="ctg248_5"
                     /protein_end="675"
                     /protein_start="41"
                     /score="498.9"
                     /tool="antismash"
                     /translation="EPAFMEALWLASPSLAREAERWRDGEKAPGTSQLLGLLRYLIRAT
                     TRPTPFGLFAGVAFVPIEEQTRLRLAGLGSHQKRARLDYGQALAFVQSLERDPALRSEL
                     YVYANPALLRWYSRIRVTCRDGYGRGQDPGQAWIRLTDPVQVILEYAARPVQYGDLIRR
                     LQERYPQSSEVDIDLFLLKLLDESVLLSTLRPPLTEMEPHSYLARMIPPTSPPSETTER
                     VLQASRLIQEINATKIGEGTKLLKALYEEFGLQQGDRQHLIQMDLRLGLEEASLSHQVI
                     APLQKAARLLAQLFGTRSPAEASLRQYAQAFLERYGLREVPLLELLDEELGLGPPPGYH
                     NPPPRRSWARSALPEPPELREIYHILAEQVSLCLREGRLDLDLEDVALPQSELEVALPP
                     AVEVFFSIHGEGETPTLVISPAGFVTSRGGVFGRFAYIDERFHQMLRALAEEEVHRYPD
                     YAFAEVVYSDRVGHHTNVALHPSLYPYQIAVGVAPSVPFERQIPLSELMVGVDGQRFYV
                     YSPSLDRIVLPRAPHVLNPQLAPNSVRFLREVGEQGLAVVPTWQWGPLSTLPFLPRVRL
                     GQVVLAPARWRLPRPLPRDLGALDRWRAQWQVPRYVYIGSHDNRLLLDLDHPACFELL"
     aSDomain        4599..5390
                     /aSDomain="TIGR03891"
                     /aSTool="tigrfam"
                     /description="thiopep_ocin: thiopeptide-type bacteriocin
                     biosynthesis domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg248_5_0001"
                     /evalue="7.40E-44"
                     /identifier="TIGR03891"
                     /label="ctg248_5"
                     /locus_tag="ctg248_5"
                     /protein_end="1006"
                     /protein_start="742"
                     /score="148.6"
                     /tool="antismash"
                     /translation="IYLKLYGPATFQNDILFALHQFLKEHGSPNWFFVRYQDPDDHLRV
                     RIFGKEGELGEFLSRFSREAHRYAENGFLLRWATDTYEPEFERYGGEAGLAVCEEIFCV
                     ETRALLELFALKPPLPLRELALFSVDGLLEGLGMSAKDRYHLYHKLVEVHLKDLGQAGK
                     EKIQQWKREFGQARSRLWQVMSWFRGGTVGSGPPADQPAKWYGDFKTQLGPLGRALQEL
                     ERRHMLLYPIGHVAASLIHMNANRLGLFQDEEHRLTYFLYAL"
     PFAM_domain     4641..5393
                     /aSDomain="Lant_dehydr_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14028.8"
                     /description="Lantibiotic biosynthesis dehydratase C-term"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_5_0004"
                     /evalue="1.20E-37"
                     /label="ctg248_5"
                     /locus_tag="ctg248_5"
                     /protein_end="1007"
                     /protein_start="756"
                     /score="130.3"
                     /tool="antismash"
                     /translation="ILFALHQFLKEHGSPNWFFVRYQDPDDHLRVRIFGKEGELGEFLS
                     RFSREAHRYAENGFLLRWATDTYEPEFERYGGEAGLAVCEEIFCVETRALLELFALKPP
                     LPLRELALFSVDGLLEGLGMSAKDRYHLYHKLVEVHLKDLGQAGKEKIQQWKREFGQAR
                     SRLWQVMSWFRGGTVGSGPPADQPAKWYGDFKTQLGPLGRALQELERRHMLLYPIGHVA
                     ASLIHMNANRLGLFQDEEHRLTYFLYALY"
     CDS             5447..6730
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     253.6; E-value: 5.2e-77)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg248_6"
                     /sec_met_domain="LANC_like (E-value: 2.5e-46, bitscore:
                     147.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPAFLWVPQVITVSEEVLSRLSDRKTVLAAVERLPPFKAGEARP
                     QWDPASMSFGDAGLAWTFAHAAQTGLDSSWEWVARHYLDHALEHALEHPSPSVGLLSGL
                     AGLAWVDHKLNGLARRAVNARLFQGVSALLKESPPNGGVHPTVFDATYGLAGVGRYLLA
                     IAPQNADAEYLLRKILRRFIAWSQRTAPEGFFTPAHEVRPFEMADRPELAQGYLDLGLA
                     HGIPGPLALLSLAWGSGLREPGMEQAAALLVRRIQQTLRETPYGPDVPYRQLPILRQSP
                     EPSRTGWCYGNPGVARALQLAARSFAQPDWAALARELVRSAIRRPIEIRGLAAPTFCHG
                     LSGFLAVLLHFETDLPSDEWKEAVNNVIDRMFAHYEPNTAFGFQNQEVNLQSLDDPSLQ
                     TGAAGVALVLLAASGMLGEAWDAVFLLA"
     PFAM_domain     5582..6685
                     /aSDomain="LANC_like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05147.15"
                     /description="Lanthionine synthetase C-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_6_0005"
                     /evalue="4.90E-41"
                     /label="ctg248_6"
                     /locus_tag="ctg248_6"
                     /protein_end="413"
                     /protein_start="45"
                     /score="140.6"
                     /tool="antismash"
                     /translation="QWDPASMSFGDAGLAWTFAHAAQTGLDSSWEWVARHYLDHALEHA
                     LEHPSPSVGLLSGLAGLAWVDHKLNGLARRAVNARLFQGVSALLKESPPNGGVHPTVFD
                     ATYGLAGVGRYLLAIAPQNADAEYLLRKILRRFIAWSQRTAPEGFFTPAHEVRPFEMAD
                     RPELAQGYLDLGLAHGIPGPLALLSLAWGSGLREPGMEQAAALLVRRIQQTLRETPYGP
                     DVPYRQLPILRQSPEPSRTGWCYGNPGVARALQLAARSFAQPDWAALARELVRSAIRRP
                     IEIRGLAAPTFCHGLSGFLAVLLHFETDLPSDEWKEAVNNVIDRMFAHYEPNTAFGFQN
                     QEVNLQSLDDPSLQTGAAGVALVLLAAS"
     CDS             6739..7623
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.3; E-value:
                     3.7e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg248_7"
                     /transl_table=11
                     /translation="MRDSILFFQEVSKAYGSVRALEGVSLTLAPGEKVALLGPNGSGKT
                     TLVHLSVGLLRPDTGRVELFGESPKSLRARRRLGVMLQSAAIPPTLRVREAVELFRSYY
                     PDPLPLAETLHLAGLEGLEDRWYGRLSGGQQRRVQFALAICGNPELLVLDEPTVGLDPD
                     YRRAFWKSLYEWAQGKTLFFTTHYLDEADRWAERVVVLHKGRVRADGPVKWVKSQLGGK
                     VIRFRSHIGSKAFESLPGVLQASAVGDYVELATERPESVIPQILAVDPNLSDLEVREPA
                     LEEVFHELIREQA"
     PFAM_domain     6799..7209
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_7_0006"
                     /evalue="1.00E-26"
                     /label="ctg248_7"
                     /locus_tag="ctg248_7"
                     /protein_end="157"
                     /protein_start="20"
                     /score="94.1"
                     /tool="antismash"
                     /translation="LEGVSLTLAPGEKVALLGPNGSGKTTLVHLSVGLLRPDTGRVELF
                     GESPKSLRARRRLGVMLQSAAIPPTLRVREAVELFRSYYPDPLPLAETLHLAGLEGLED
                     RWYGRLSGGQQRRVQFALAICGNPELLVLDEPT"
     CDS             7672..7863
                     /locus_tag="ctg248_8"
                     /transl_table=11
                     /translation="MHPLDSTFRTFLLRLDPRLYAVLEKCAQDELRSVNAQIEYLLKEA
                     ARRAGRWKKEEGRVKSYV"
     CDS             complement(7847..8113)
                     /locus_tag="ctg248_9"
                     /transl_table=11
                     /translation="LRSTNLMERFIRELRRGTKVRDHKFPKEEAVYKLLYLESERQAAS
                     RSEHLAGRWAERKLKGFSEVKEVLEKMLQERYAPRTQTLTHNS"
     PFAM_domain     complement(8003..8110)
                     /aSDomain="Transposase_mut"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00872.20"
                     /description="Transposase, Mutator family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg248_9_0007"
                     /evalue="6.40E-05"
                     /label="ctg248_9"
                     /locus_tag="ctg248_9"
                     /protein_end="37"
                     /protein_start="1"
                     /score="22.1"
                     /tool="antismash"
                     /translation="RSTNLMERFIRELRRGTKVRDHKFPKEEAVYKLLYL"
ORIGIN
        1 gccccaggcc ccccgggtcc accccgtggt catccccgac ctccccagcc tctccggcct
       61 cctggtccgg cccggggacc gggtggagga gggggagccg ctagcccgct acaccgaccc
      121 cgcccccctg gaggacctcg aggcccaggc ccaggccaag cgggaggagg cccagagact
      181 tgagggggaa atccgcgccc tggaggagcg cttccgggcc gagcgggagg ccctggagcg
      241 ggagcgggcc cgggcccggg aggagcggga ccgcctccgc tacctggtct cccagggggc
      301 cgagcccgcc ctccgcctgg ccgaggccga ggggcgcctc gaggaggcgg aggggaggct
      361 ccggaagctc gtcctggact acaccaccca gagggcccgc ctggaggagt cggcgcggga
      421 ggcccgcctc gaggcggccc gcctggaccg gaggcgggag cgggaggcgg agcgccagct
      481 ggtccgcgcc cccgtctccg gccgggtggc cgaggtcaag gtgcgggacc tcacgcccaa
      541 gggggtgacg gtggaggtgg tgctggttca gtaaagaggg aggccagcgg atagagagcg
      601 tcgtttcccg aagggaacac taagctgctt cccgagggga acacggggag gcgctcaagg
      661 tctggtacag gggtctgagc agggggtagc cgggcgaaag gttaactcaa cgagcccctc
      721 gctccagatc tcctaaaata attgcgacat gacctgccac tccggcgtag agaccttgcg
      781 gctccacggc ctagccctcc tggcgtccgc tcagctctct cgccccgtcc acttggtgct
      841 ggatgccccc tggggcttca ccctgtgggg cttggcccag ctcccgcggc cctgcctcat
      901 cgtgacccag tgtccttcac cccactacct gcgcgacctg atggacctgc aaccggaggg
      961 gatcctggcc acctcggcaa acccggagga catactccgg ggtctacaag ccgtagccca
     1021 ggatcagccc tttcacaagc tcccgccttt aggcccagag atccttaccg tgcgcgagcg
     1081 gcaggttatg cgtctggtgg cgctgggtct gagcgacgcc gagatcgccc ggaggttgag
     1141 tgtatccaag cggacggtgt ataactgggt gtccagccta caggacaagc tgggcttgga
     1201 gaaccgagtg gagctcgcgc tgtactacct gggcttgctc ccccactgcc gtgggtggcg
     1261 tgggatgtga gtttttactg gcttggatgt gagcttttct cttgaatcca aaatcccgtg
     1321 gctctatttt aaaggcgacc cccaagagtt ggggcggaaa gaggagggag gttgtgtatg
     1381 gcagttgcaa gcctcaaccc ttttgatctg gctagtctag acatcaggac cagtgccgca
     1441 atggatgcag gtacggtgag cccgcaaagt actttggtct gcgcaaccat cgtcattagt
     1501 tttcgcagca acttgtgctg cgttgtcacc atcaccctgc tggcctgtcc ccgaactgag
     1561 gaactgccgg cttgagcgcc gctttcgggc ctcagcggtc gttggggccc cttttttttc
     1621 tcaaagcagc ttatgaacgc gacgaggggt aacccctact ttttggaggc taaatacgac
     1681 ctactccagc agctgcggat ccccgggcag ttcatcggca ccccgcttgg cggtgtaggt
     1741 gcttatgggc tgctcctcct aatgggccgc gacctcggcg gcctcggcga ggaattcctc
     1801 gtccgcttcg ccgccttagg ggtcatgaac gtagggctgc tcgcgatagg gctaggggca
     1861 gcctcggagc gcgcctacgg ctggatccgc ctgcgccagg tagcgcccat gccgcccctg
     1921 gcttatttcc tggggaaggt ttccacaggg gcggttatgg ccgccctgac cgccttgggt
     1981 gtgctcctgg tggagctggt cttcggggcg gtttcctggc cctactacgc ctgggtttcg
     2041 ctgacgctgg ccctggtgct gggcagtctg cccttcaccg ccttgggcct ggccgcggcc
     2101 tacctcgtgc ggccgaactc ggctcagccg cttatcgtct ataccgcggc attcgtcctt
     2161 ttcccggtgt tcatgccttt gcttcgcctc ccagagtgga tccagaccat cttctcgtac
     2221 cttccgagcg ccctcttcat tgatttagcg cttggtgcgg taggcctggc ctcgccctcg
     2281 cttccttctt tcgtgctgct cgccgcgtat accatagcct tcctgctgct ggccgcgtgg
     2341 ctttttggcc gcgacgaggg cagcaccttc ggatgatctg ggggtgcacg gtgcaagggg
     2401 ctatggtgcg cgtcccgctg ttccccgtcg agtggtatct tcaggcgcta tctgcaccag
     2461 acgggctcgc cgactatctt ttggaaatcc tgcgcgaacc ggctttcatg gaggcgttgt
     2521 ggctggcgag cccaagcctg gcacgcgagg ccgagcgttg gcgagacgga gagaaagcgc
     2581 cgggtacaag tcagctgtta gggctgttgc ggtacctcat tcgggccacc acgcgaccca
     2641 ccccgtttgg tctattcgct ggagtggcat ttgtaccgat tgaggagcag acacggctgc
     2701 ggttggctgg cctcggcagc catcagaagc gggctcgatt ggactatggc caggcgctcg
     2761 cctttgtgca gtccctcgag cgcgatccgg cgttgcgctc tgaactctac gtttacgcca
     2821 atccagcact gttgcgctgg tacagccgga ttcgcgttac ctgccgggat ggctacggtc
     2881 ggggccagga tccaggacag gcttggatac gccttaccga tccggtgcaa gtaatcctcg
     2941 aatacgctgc tcggccagtc cagtatggcg acttaatccg ccggctgcaa gagcgctacc
     3001 cacagagttc agaagtcgat atcgacctct tcctgctcaa actgctggac gaaagcgtgc
     3061 tcctgagcac cttgcgacct cccctcaccg agatggaacc tcattcgtac cttgcgcgca
     3121 tgatcccgcc aacctcccca cccagcgaga cgactgaaag ggtgctacaa gcttcgaggc
     3181 ttattcaaga aatcaatgcg acgaagattg gggaaggcac caagctcctc aaagcccttt
     3241 acgaagaatt tggcttgcag caaggggatc gacaacattt gatccagatg gatctcaggt
     3301 tgggcctaga ggaggccagc ctatctcatc aggtaattgc cccactacag aaagcagctc
     3361 gcctgctggc ccagctcttc ggtacccgct cacctgccga ggcttctctc cgccagtacg
     3421 cgcaagcatt tctcgaacgg tacgggctgc gggaggtgcc cctgctcgaa ctgctggacg
     3481 aggagctcgg gcttggaccg ccgcctggct accacaaccc cccacctcgc cgctcatggg
     3541 ctaggtcagc gcttccggag ccgccggagt tgcgtgagat ctatcatatc ctggctgagc
     3601 aggtttccct gtgtttgcgg gaggggcggc tcgatctgga ccttgaggac gttgccctgc
     3661 ctcagagcga actcgaggta gccctacccc cagcggttga ggtctttttt agcatccacg
     3721 gtgagggcga aacgccgacc ctggtcatca gcccagcagg atttgtcacc agcaggggcg
     3781 gggtcttcgg acgcttcgcc tatattgatg aacgtttcca tcagatgctc agggcgctag
     3841 ccgaggaaga ggtacaccgt tatcccgact atgcttttgc tgaggttgtc tactcggacc
     3901 gagtcggcca tcacaccaac gtcgcccttc acccgagcct ctacccttat cagattgcgg
     3961 ttggagtcgc tcctagtgtt ccttttgaac gccaaattcc gcttagcgag ctgatggttg
     4021 gagtggacgg gcagcggttt tacgtttact cgcccagtct cgaccgcatt gtgttgccac
     4081 gggctcccca cgtgctcaac cctcaacttg cacccaattc ggtgcgcttt ctccgtgaag
     4141 tcggcgagca agggcttgcg gttgtaccga catggcagtg gggtcccttg agcaccctac
     4201 ccttcctgcc gcgggttcgg ctgggccagg tggtactggc ccccgcccgc tggaggctcc
     4261 cccggccgct accacgagac ctcggggccc tagaccgctg gcgagcccag tggcaagtac
     4321 cccgctacgt ctacatcggc agccacgaca atcggctact gttagacctg gatcacccag
     4381 cctgttttga actacttcgc cgggaggccc cagaatatgt cgaggaagcc cccgaccccc
     4441 actcggcctg ggtgagcggc ggcagtggcc accacatggc tgagtacgta ctccggctgc
     4501 cgctcggctc ggctggggag tcctaccccc agcgggcggc aagatcggtg caaagccttg
     4561 accctgtccg taggatgcgc tttccgggcc agagggttat ctacctcaag ctgtacggcc
     4621 cggccacctt ccaaaacgat atactcttcg ccttacacca atttctaaag gagcatggct
     4681 cccccaactg gtttttcgtg cgctaccaag accctgacga ccacctacgg gtgcgcatct
     4741 tcggcaaaga gggtgagctc ggtgagttcc tgagtcgctt cagccgagag gcccatcgct
     4801 acgccgaaaa cgggtttttg ctgcgttggg ctactgacac ttatgagccg gagttcgagc
     4861 gatacggcgg cgaggctggc ttggccgttt gtgaggaaat cttctgcgtt gaaacacgcg
     4921 cgctactcga gctattcgct ctaaaaccgc ccttgccgct ccgtgagctg gctctatttt
     4981 ctgtagatgg ccttttagag gggctgggca tgagcgccaa ggaccgttac cacttgtatc
     5041 acaaactagt agaggtccac ctaaaagatc taggccaagc aggcaaggag aaaatacagc
     5101 aatggaagcg tgagtttggc caagcccgat cccggctgtg gcaagttatg tcttggttcc
     5161 gcgggggcac ggtgggatca gggccaccag ccgatcagcc ggccaaatgg tacggcgact
     5221 tcaagaccca gcttggccct ctaggccggg cgctccaaga gctggagcgg cggcatatgc
     5281 tgctctaccc cataggccac gtggcggcca gcctgatcca tatgaatgcc aaccgcctgg
     5341 gcctattcca agatgaggag caccgcctca cgtactttct ttacgctctg tacgatggtt
     5401 tccgccacta catcccggct acgctcccct taacttggga ggagatatga aaccggcctt
     5461 cctctgggtt cctcaagtga taaccgtatc cgaagaggtt ctttcacggt tgtctgaccg
     5521 aaaaaccgtc ctcgcggcag tcgagcggct accgccgttt aaggcaggcg aagcccgtcc
     5581 ccagtgggat cctgctagca tgagcttcgg cgacgctggt ctagcttgga cgtttgccca
     5641 cgccgcgcag acagggctcg actcaagctg ggagtgggtg gcccggcact accttgatca
     5701 tgcccttgag catgcccttg agcatccctc tccctcagtg ggattgctca gcggcttggc
     5761 aggtctggct tgggtggatc ataagctaaa tggactggcg cggcgggcag tgaacgccag
     5821 actgtttcaa ggggtgagcg ctctgcttaa ggagtctcct cccaacggag gagttcaccc
     5881 taccgtcttc gacgctacgt atgggcttgc tggagtggga cgctacttgt tggctatagc
     5941 cccccagaac gcagatgcgg agtacttgct gcgcaagatt ttgcgcaggt tcatagcctg
     6001 gagtcagcgg actgcgcctg aggggttttt cacccccgcc catgaggtgc gccctttcga
     6061 gatggccgat cgtcctgagc tagcccaggg ttatctggac cttggattgg cccatgggat
     6121 tcccggccca cttgccctgt taagccttgc ttggggttcg ggcttgcgtg agccagggat
     6181 ggagcaagcg gcagcgctat tggtgcggcg catacagcaa actctgcgtg agacccccta
     6241 tgggccagac gtaccctacc gccaacttcc gattttgcga caatccccag aaccttcgcg
     6301 cacgggctgg tgctacggaa accccggcgt ggcccgcgcc ctccagctgg cagccagaag
     6361 cttcgcccaa cccgattggg cagcgctggc gcgtgagctc gtccgttcgg cgatcaggcg
     6421 ccccattgaa atacgggggc tcgcggctcc aaccttctgc catgggctgt cgggcttctt
     6481 ggctgttcta cttcacttcg aaactgacct tcccagcgat gagtggaaag aggctgtaaa
     6541 caacgtcatt gatcggatgt ttgctcacta cgaacccaac actgcattcg gttttcaaaa
     6601 tcaagaggta aatctacaat ccctggacga cccgagctta caaactggtg cggccggggt
     6661 tgctctggtg ttgctggccg cgtcagggat gttgggggaa gcctgggacg cggttttctt
     6721 gttggcgtag agggcatgat gagagatagc atcctgttct tccaagaggt cagcaaggct
     6781 tacggcagcg tgcgggcgct tgaaggggtg agcctgacgc ttgccccggg ggaaaaggtg
     6841 gcgctcctgg ggccaaatgg gtcaggaaag accactttgg tgcacttgtc cgtgggactc
     6901 ctacgcccgg acacaggccg ggtggagctg ttcggtgaga gccctaaatc gctcagggcc
     6961 cgccgccggt taggggtcat gttgcagtcg gccgccatcc ccccgaccct gcgggtgcgc
     7021 gaggcggtgg agctcttccg gagctactac cccgacccgc tccctttggc cgaaacgctc
     7081 cacctggcgg ggctagaggg cctcgaggat cgttggtatg gtcgtctctc cggagggcag
     7141 cagcggcggg tgcagtttgc cctagccatc tgcggcaatc cagagctcct tgtgcttgac
     7201 gagcccaccg taggcttaga tccagattac cggcgggctt tctggaaatc cctatacgaa
     7261 tgggctcagg ggaagaccct gttcttcacc acccactacc tagatgaggc cgaccgctgg
     7321 gcggagcggg tcgtcgtgct ccacaaaggg cgggtgcggg ccgatgggcc ggtgaagtgg
     7381 gtaaaatcgc agttaggggg caaggttatc cgctttcgca gccacatcgg ctctaaagcc
     7441 tttgaaagcc tgcccggtgt gctccaggct tccgcagtgg gggattatgt tgagctggct
     7501 accgagcggc ccgagtcggt cattccccag atcctagccg ttgatcccaa cctgagcgac
     7561 ttggaggtgc gtgaaccagc cctagaagag gtgtttcacg agctgatccg agagcaggct
     7621 tagctccctc ttttgcccta tgaccaggct catctggagc gcgctccgca tatgcacccc
     7681 ctagactcca cattccgcac cttcctcctg cgcctggacc ccaggctcta cgccgtcctg
     7741 gagaagtgtg cgcaggacga gcttcggagc gtcaatgccc agatagaata cctcctaaag
     7801 gaggcggccc ggcgggcggg ccggtggaag aaagaggagg gtcgtgtcaa gagttatgtg
     7861 taagagtctg tgtacggggg gcataccgct cctgaagcat cttctccagc acctccttca
     7921 cctccgagaa cccctttagt ttccgttctg cccacctccc tgcaagatgt tcgcttcgcg
     7981 aagcagcctg cctctccgac tccaggtaaa gaagcttgta caccgcctct tccttaggaa
     8041 acttgtggtc ccgcaccttc gtcccccgcc gtagctcccg gataaaccgc tccatcaggt
     8101 tggtgctccg caa
//
