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Overview
1.1
1.2
3.1
3.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KE392228.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | RRE-containing | 41,438 | 60,786 |
Region 1.2 | RRE-containing | 128,572 | 153,399 |

NZ_AUUB01000014 (original name was: NZ_AUUB01000014.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | ranthipeptide | 140,005 | 161,662 |
Region 3.2 | cyclic-lactone-autoinducer | 169,503 | 190,319 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | RRE-containing | 41,438 | 60,786 |
Region 1.2 | RRE-containing | 128,572 | 153,399 |
Region 3.1 | ranthipeptide | 140,005 | 161,662 |
Region 3.2 | cyclic-lactone-autoinducer | 169,503 | 190,319 |

No secondary metabolite regions were found in these records:
  NZ_KE392229.1
  NZ_AUUB01000015 (original name was: NZ_AUUB01000015.1)
  NZ_AUUB01000016 (original name was: NZ_AUUB01000016.1)
  NZ_AUUB01000017 (original name was: NZ_AUUB01000017.1)
  NZ_AUUB01000018 (original name was: NZ_AUUB01000018.1)
  NZ_AUUB01000019 (original name was: NZ_AUUB01000019.1)
  NZ_AUUB01000020 (original name was: NZ_AUUB01000020.1)
  NZ_AUUB01000001 (original name was: NZ_AUUB01000001.1)
  NZ_AUUB01000002 (original name was: NZ_AUUB01000002.1)
  NZ_AUUB01000003 (original name was: NZ_AUUB01000003.1)
  NZ_AUUB01000004 (original name was: NZ_AUUB01000004.1)
  NZ_AUUB01000005 (original name was: NZ_AUUB01000005.1)
  NZ_AUUB01000006 (original name was: NZ_AUUB01000006.1)
  NZ_KE392230.1
  NZ_AUUB01000009 (original name was: NZ_AUUB01000009.1)

Compact view
NZ_KE392228.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 41,438 - 60,786 nt. (total: 19,349 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.23 | RiPP | siamycin | Streptomyces nodosus
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000496.1 |  | 0.16 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001210.1 |  | 0.16 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000938.1 |  | 0.16 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000626.1 |  | 0.16 | RiPP | thuricin | Bacillus thuringiensis
BGC0000764.1 |  | 0.16 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000487.1 |  | 0.16 | RiPP | carnocyclin | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.56 | RiPP | siamycin | Streptomyces nodosus
BGC0000519.1 |  | 0.47 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000551.1 |  | 0.47 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000496.1 |  | 0.47 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000501.1 |  | 0.47 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001210.1 |  | 0.47 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000938.1 |  | 0.47 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000626.1 |  | 0.46 | RiPP | thuricin | Bacillus thuringiensis
BGC0000764.1 |  | 0.46 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000487.1 |  | 0.46 | RiPP | carnocyclin | Carnobacterium maltaromaticum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KE392228.1 - Region 2 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 128,572 - 153,399 nt. (total: 24,828 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001655.1 |  | 0.17 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0001863.1 |  | 0.16 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001586.1 |  | 0.16 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000617.1 |  | 0.16 | RiPP | coagulin | Bacillus coagulans
BGC0000491.1 |  | 0.16 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000500.1 |  | 0.16 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000543.1 |  | 0.16 | RiPP | pep5 | Staphylococcus epidermidis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001655.1 |  | 0.48 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0001863.1 |  | 0.47 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001586.1 |  | 0.47 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001222.1 |  | 0.47 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000504.1 |  | 0.46 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000617.1 |  | 0.46 | RiPP | coagulin | Bacillus coagulans
BGC0000491.1 |  | 0.46 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000500.1 |  | 0.46 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000543.1 |  | 0.46 | RiPP | pep5 | Staphylococcus epidermidis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00003_NZ_AUUB.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 140,005 - 161,662 nt. (total: 21,658 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.17 | Other | nucleocidin | Streptomyces calvus
BGC0001887.1 |  | 0.14 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001935.1 |  | 0.12 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.12 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000695.1 |  | 0.11 | Saccharide | fortimicin | Micromonospora olivasterospora
BGC0001860.1 |  | 0.09 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.09 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.1 |  | 0.08 | RiPP | GE2270A | Nonomuraea sp. WU8817
BGC0001155.1 |  | 0.07 | RiPP | GE2270 | Planobispora rosea
BGC0001591.1 |  | 0.07 | Other | fatty acid enol ester | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.49 | Other | nucleocidin | Streptomyces calvus
BGC0001887.1 |  | 0.44 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001935.1 |  | 0.39 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.39 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000695.1 |  | 0.37 | Saccharide | fortimicin | Micromonospora olivasterospora
BGC0001860.1 |  | 0.33 | RiPP | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.1 |  | 0.33 | RiPP | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000604.1 |  | 0.31 | RiPP | GE2270A | Nonomuraea sp. WU8817
BGC0001155.1 |  | 0.30 | RiPP | GE2270 | Planobispora rosea
BGC0001591.1 |  | 0.28 | Other | fatty acid enol ester | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00003_NZ_AUUB.. - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 169,503 - 190,319 nt. (total: 20,817 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.13 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000469.1 |  | 0.08 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0001686.1 |  | 0.07 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001941.1 |  | 0.07 | NRP, Polyketide | fulvuthiacene A, fulvuthiacene B | Myxococcus fulvus
BGC0001890.1 |  | 0.07 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001945.1 |  | 0.05 | NRP | chloromyxamide | Myxococcus sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001859.1 |  | 0.42 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000469.1 |  | 0.30 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0001686.1 |  | 0.29 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0001941.1 |  | 0.29 | NRP, Polyketide | fulvuthiacene A, fulvuthiacene B | Myxococcus fulvus
BGC0001890.1 |  | 0.28 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001945.1 |  | 0.21 | NRP | chloromyxamide | Myxococcus sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names