LOCUS       NZ_KB907789.1          12214 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_KB907789.1 Dyadobacter beijingensis DSM 21582
            H144DRAFT_scaffold00004.4, whole genome shotgun sequence.
ACCESSION   NZ_KB907789
VERSION     NZ_KB907789.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:10:29
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2761
            Orig. end    :: 14975
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12214
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[7761:9975](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7214
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12214
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12214
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1084..1599
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="MVLKSISCWHEILYLGGIFVMTDFANFNRRQSYFRPYQTHLDVYA
                     RLKKVDLKAMATGKWSYKFKIFCFIPIILFQCECVGCNILIHLNMPLLRKLSATSWLDT
                     RQLTFMLLISDASRDNEVLGAQTIKISQADSDTIRSACKSQRTFSSMQIEDLVDIIYQL
                     EIGSIWQS"
     CDS             complement(2501..2758)
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MDESIGFRVRSVALNIRKIREYRDYTQEYLAMKLGISQNAYSKIE
                     LGYTRITLERLIQIAQILGVDSADLFHADSEGLVRLYKTG"
     PFAM_domain     complement(2552..2713)
                     /aSDomain="HTH_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01381.24"
                     /description="Helix-turn-helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_3_0001"
                     /evalue="3.60E-16"
                     /label="ctg4_3"
                     /locus_tag="ctg4_3"
                     /protein_end="69"
                     /protein_start="15"
                     /score="59.1"
                     /tool="antismash"
                     /translation="IRKIREYRDYTQEYLAMKLGISQNAYSKIELGYTRITLERLIQIA
                     QILGVDSAD"
     CDS             3429..3617
                     /locus_tag="ctg4_4"
                     /transl_table=11
                     /translation="MKEINGGLLGLGNSSDSASSGGLFGSLGVAFSNESVDDDGSSEKT
                     QFGLGLDLGGIFNSITG"
     CDS             3692..4906
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 107.5; E-value:
                     1.2e-32)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_5"
                     /transl_table=11
                     /translation="MDKDHSSTRNKIFPPEILEYTSDYHFHQHHTRSNLIYQLLLLIII
                     VGFISMFLIAVDVSVRSTGIIRASDDRNEIKALVSGRLDSVFVAENQRVEKGQTLLKIE
                     AEIIKEQNQLVKAQKTDFDNQIRDLKVLLHLSRTNNWSKKPGLVSGLYKQDFALFWQKI
                     TDAKTTLLTVEKDFARNKILHDVKAISEAEFDKAVLLHTTAKNRIKTIMEEEEARWESE
                     LTQLQMKSRELNSQDQQYLREKDYYVVKAPISGTIQQLKGLRPGSIVASNEFLAEISPD
                     EAMIAEMYVLPKDIGLIHPGTLTRLQVDAYNYNQWGLVTGRVLSISNDVYTDGKQPPYF
                     KVRCKLDKSSLTLKSGYEGKLKKGMTLQARFLVTERTLFQLLYDKADDWLNPNLVATTE
                     TPPLN"
     PFAM_domain     3914..4045
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_5_0002"
                     /evalue="4.70E-08"
                     /label="ctg4_5"
                     /locus_tag="ctg4_5"
                     /protein_end="118"
                     /protein_start="74"
                     /score="32.8"
                     /tool="antismash"
                     /translation="IKALVSGRLDSVFVAENQRVEKGQTLLKIEAEIIKEQNQLVKAQ"
     PFAM_domain     4433..4759
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_5_0003"
                     /evalue="5.30E-15"
                     /label="ctg4_5"
                     /locus_tag="ctg4_5"
                     /protein_end="356"
                     /protein_start="247"
                     /score="56.1"
                     /tool="antismash"
                     /translation="VVKAPISGTIQQLKGLRPGSIVASNEFLAEISPDEAMIAEMYVLP
                     KDIGLIHPGTLTRLQVDAYNYNQWGLVTGRVLSISNDVYTDGKQPPYFKVRCKLDKSSL
                     TLKSG"
     CDS             5001..7214
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 319.6; E-value:
                     6.7e-97)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_6"
                     /sec_met_domain="TIGR01193 (E-value: 4.1e-160, bitscore:
                     530.3, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.2e-36, bitscore:
                     119.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRADVVIKQHDLTDCGATCLASIAAFYKLTIPVARIRQYASTDQ
                     KGTNVLGLIEAATKLGFTSKGVKADFEQLPHVPVPVIAHVIIKQVLHHYVVVYNITGST
                     VEVMDPARGEIIPMSYDEFRSIWTGVLVLVQPGDTFLEGNEKISVQKRFWYLIKPHNAI
                     LVQVLIGAIIYTILGLSTSIFLQKIVDNVLPEGNRNLLNLMGVVMIGILFFRIIINHAK
                     TLLTIKTGQQIDARLILGYYKHLLRLPQQFFDNMRVGEIISRINDAVKIRVFINDVLVG
                     FAVNMFILLFSFVLMFTYYWKLALIMLCVVPLYAVIYFFSNRMNKSTQRKLMESSAELE
                     AQLVESIHSVSTIKRFGLEDFTNMRTETRFVGMLRSVYESNTNSLWIGDFSGFVASAFT
                     IILLWAGSLFVLNNIITPGELLSFYAIIGYFTGPVSSLIGMNKTIQDASIAADRLFEIM
                     DIERESVENKAILTPDMIGDIHFRNVHFRYGTRVTVFEGLDLVIPKNKITAVVGESGSG
                     KTTLLALLQNIYPIEQGNIQLGGFDIKYLTNDSLRQMVSAVPQDVHLFAGNVISNIAVG
                     EFEPDMKKIVSICQELDIMKFIENLPNGFNTYIGENGTSLSGGQRQRLAIARALYRDPE
                     ILILDEATSSLDSKSEQHIQLAIQSLRKKNKTIIIIAHRLSTVMNADKIVVLEHGKLVQ
                     EGTHKKLISQKGRYFDMWEQQFPTLQNEKPFARSRNGINSSPG"
     PFAM_domain     5019..5414
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_6_0004"
                     /evalue="8.40E-35"
                     /label="ctg4_6"
                     /locus_tag="ctg4_6"
                     /protein_end="138"
                     /protein_start="6"
                     /score="119.6"
                     /tool="antismash"
                     /translation="VIKQHDLTDCGATCLASIAAFYKLTIPVARIRQYASTDQKGTNVL
                     GLIEAATKLGFTSKGVKADFEQLPHVPVPVIAHVIIKQVLHHYVVVYNITGSTVEVMDP
                     ARGEIIPMSYDEFRSIWTGVLVLVQPGD"
     aSDomain        5028..7133
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg4_6_0001"
                     /evalue="1.90E-159"
                     /identifier="TIGR01193"
                     /label="ctg4_6"
                     /locus_tag="ctg4_6"
                     /protein_end="711"
                     /protein_start="9"
                     /score="530.3"
                     /tool="antismash"
                     /translation="QHDLTDCGATCLASIAAFYKLTIPVARIRQYASTDQKGTNVLGLI
                     EAATKLGFTSKGVKADFEQLPHVPVPVIAHVIIKQVLHHYVVVYNITGSTVEVMDPARG
                     EIIPMSYDEFRSIWTGVLVLVQPGDTFLEGNEKISVQKRFWYLIKPHNAILVQVLIGAI
                     IYTILGLSTSIFLQKIVDNVLPEGNRNLLNLMGVVMIGILFFRIIINHAKTLLTIKTGQ
                     QIDARLILGYYKHLLRLPQQFFDNMRVGEIISRINDAVKIRVFINDVLVGFAVNMFILL
                     FSFVLMFTYYWKLALIMLCVVPLYAVIYFFSNRMNKSTQRKLMESSAELEAQLVESIHS
                     VSTIKRFGLEDFTNMRTETRFVGMLRSVYESNTNSLWIGDFSGFVASAFTIILLWAGSL
                     FVLNNIITPGELLSFYAIIGYFTGPVSSLIGMNKTIQDASIAADRLFEIMDIERESVEN
                     KAILTPDMIGDIHFRNVHFRYGTRVTVFEGLDLVIPKNKITAVVGESGSGKTTLLALLQ
                     NIYPIEQGNIQLGGFDIKYLTNDSLRQMVSAVPQDVHLFAGNVISNIAVGEFEPDMKKI
                     VSICQELDIMKFIENLPNGFNTYIGENGTSLSGGQRQRLAIARALYRDPEILILDEATS
                     SLDSKSEQHIQLAIQSLRKKNKTIIIIAHRLSTVMNADKIVVLEHGKLVQEGTHKKLIS
                     QKGRYFDM"
     PFAM_domain     5499..6302
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_6_0005"
                     /evalue="4.00E-48"
                     /label="ctg4_6"
                     /locus_tag="ctg4_6"
                     /protein_end="434"
                     /protein_start="166"
                     /score="164.5"
                     /tool="antismash"
                     /translation="VLIGAIIYTILGLSTSIFLQKIVDNVLPEGNRNLLNLMGVVMIGI
                     LFFRIIINHAKTLLTIKTGQQIDARLILGYYKHLLRLPQQFFDNMRVGEIISRINDAVK
                     IRVFINDVLVGFAVNMFILLFSFVLMFTYYWKLALIMLCVVPLYAVIYFFSNRMNKSTQ
                     RKLMESSAELEAQLVESIHSVSTIKRFGLEDFTNMRTETRFVGMLRSVYESNTNSLWIG
                     DFSGFVASAFTIILLWAGSLFVLNNIITPGELLSFYAIIGYFTGPV"
     PFAM_domain     6489..6932
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_6_0006"
                     /evalue="8.20E-29"
                     /label="ctg4_6"
                     /locus_tag="ctg4_6"
                     /protein_end="644"
                     /protein_start="496"
                     /score="101.0"
                     /tool="antismash"
                     /translation="GLDLVIPKNKITAVVGESGSGKTTLLALLQNIYPIEQGNIQLGGF
                     DIKYLTNDSLRQMVSAVPQDVHLFAGNVISNIAVGEFEPDMKKIVSICQELDIMKFIEN
                     LPNGFNTYIGENGTSLSGGQRQRLAIARALYRDPEILILDEATS"
     CDS             complement(7842..8195)
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MFLIVNVKQAAMEKKGKQLEERSALFTHQLVTLADLEKFKEQMLS
                     EMRKLISGGGTQHSKQWLKSREVRKLLDVSPGKLHAMRVSRQLSFMRIGGVIYYDRADI
                     DKMFDKFKTAAVK"
     PFAM_domain     complement(7866..8012)
                     /aSDomain="HTH_17"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12728.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_7_0007"
                     /evalue="1.50E-06"
                     /label="ctg4_7"
                     /locus_tag="ctg4_7"
                     /protein_end="110"
                     /protein_start="61"
                     /score="28.4"
                     /tool="antismash"
                     /translation="WLKSREVRKLLDVSPGKLHAMRVSRQLSFMRIGGVIYYDRADIDK
                     MFDK"
     CDS             complement(8331..8888)
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MRNLEHIPRIYVGTYGQYNNGSLFGKWFDLTDYVDRKEFLQDCFE
                     FHRNELDPELMFQDWENIPDFLISECSLHKEAFAYFEATGEMDDETAEAFNIYCKQINY
                     WPSNGYELDDQLEGFRESYQGFFGVSGKDAALEYAYQYVEDTGLLSGVPQAIERYFDYE
                     AFAKDLFLEGYSEHEGHIFTDY"
     PFAM_domain     complement(8349..8861)
                     /aSDomain="ArdA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07275.13"
                     /description="Antirestriction protein (ArdA)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_8_0008"
                     /evalue="3.90E-30"
                     /label="ctg4_8"
                     /locus_tag="ctg4_8"
                     /protein_end="180"
                     /protein_start="9"
                     /score="105.7"
                     /tool="antismash"
                     /translation="IYVGTYGQYNNGSLFGKWFDLTDYVDRKEFLQDCFEFHRNELDPE
                     LMFQDWENIPDFLISECSLHKEAFAYFEATGEMDDETAEAFNIYCKQINYWPSNGYELD
                     DQLEGFRESYQGFFGVSGKDAALEYAYQYVEDTGLLSGVPQAIERYFDYEAFAKDLFLE
                     GYSEHEGH"
     PFAM_domain     9418..10236
                     /aSDomain="Beta-lactamase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00144.26"
                     /description="Beta-lactamase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_9_0009"
                     /evalue="4.80E-34"
                     /label="ctg4_9"
                     /locus_tag="ctg4_9"
                     /protein_end="273"
                     /protein_start="0"
                     /score="118.2"
                     /tool="antismash"
                     /translation="MQLEAKGYFKLDDDINGFLPFRVVNPSFPAAPITFRLLLRHRSSI
                     ADNMDYLLPFWGNTYQGADIPLGTFLADYLSTSGKHYYANKNFTGAEPGSRFEYSNIGF
                     ALLGYLVERIAKIPFDQYCKAHLFTPLEMHHTNWFLEPFRSDRLAVPYEYSDSLGRYEK
                     LPQGKFPDYPAGQLRCTVSDLAKFLACWSNDGSYAGKRVIEARSVQLLTPMDMSLGFHT
                     WFMYLLNTETPTYSHSGHGPGISTYMLYDPFSKKGLIILMNGELSDYFEWR"
     CDS             9418..10266
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 112.3; E-value: 4.3e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MQLEAKGYFKLDDDINGFLPFRVVNPSFPAAPITFRLLLRHRSSI
                     ADNMDYLLPFWGNTYQGADIPLGTFLADYLSTSGKHYYANKNFTGAEPGSRFEYSNIGF
                     ALLGYLVERIAKIPFDQYCKAHLFTPLEMHHTNWFLEPFRSDRLAVPYEYSDSLGRYEK
                     LPQGKFPDYPAGQLRCTVSDLAKFLACWSNDGSYAGKRVIEARSVQLLTPMDMSLGFHT
                     WFMYLLNTETPTYSHSGHGPGISTYMLYDPFSKKGLIILMNGELSDYFEWRKLIDLLWK
                     S"
     PFAM_domain     10499..10729
                     /aSDomain="Isochorismatase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00857.22"
                     /description="Isochorismatase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_10_0010"
                     /evalue="1.60E-15"
                     /label="ctg4_10"
                     /locus_tag="ctg4_10"
                     /protein_end="77"
                     /protein_start="0"
                     /score="57.8"
                     /tool="antismash"
                     /translation="LLDDLKIDTDDIRIDKYADDVFYRSELGQKLGALAINELVITGCA
                     TDFCVESTIQSAVSKDYSITVIEDGHTTGNRP"
     CDS             10499..10852
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="LLDDLKIDTDDIRIDKYADDVFYRSELGQKLGALAINELVITGCA
                     TDFCVESTIQSAVSKDYSITVIEDGHTTGNRPSLRAHQVIDHYNWVWKNMIPTKGKIEV
                     LPHLEFLQKFAIR"
     CDS             complement(11374..11928)
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="MKKLNFFLSLITLLVIGNYSFAQEKTVTVGGAPMYPSKNIIENAV
                     NSKDHTTLVAAVKAAGLVETLSGPGPFTVFAPTNMAFDKLPKGTVDMLVKPENKEMLTG
                     ILTYHVVAGNMSAADLMKAIKNGGGKAMLKTVAGGELTAMQKGKKIVLTDAKGNLAMVT
                     IADVFQSNGVIHVIDTVLMPK"
     PFAM_domain     complement(11380..11784)
                     /aSDomain="Fasciclin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02469.24"
                     /description="Fasciclin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg4_11_0011"
                     /evalue="2.50E-30"
                     /label="ctg4_11"
                     /locus_tag="ctg4_11"
                     /protein_end="183"
                     /protein_start="48"
                     /score="105.4"
                     /tool="antismash"
                     /translation="DHTTLVAAVKAAGLVETLSGPGPFTVFAPTNMAFDKLPKGTVDML
                     VKPENKEMLTGILTYHVVAGNMSAADLMKAIKNGGGKAMLKTVAGGELTAMQKGKKIVL
                     TDAKGNLAMVTIADVFQSNGVIHVIDTVLMP"
ORIGIN
        1 gcatttgcca gggcactggg cggagaacat gtcacagaag atgtgctggt gcggcaccgg
       61 ttgactggac agcagcatgt agttcgttgt gctgcctcgc cggttgtgat agaaggcaat
      121 actatagcag ctattgcgat taataccgat gttaccgtcc agcgcaatgc ggaagaagct
      181 ttgcggcaga gccatcagca gtaccagcaa ttgtccatgc atctcgaaaa gatggtagat
      241 gaaaggacac atgaattaac tattgccaat caggaccttg tccgctccaa tgaaaatctg
      301 cagcaatttg cctatgtggc aagccatgac ttacaggaac ctctgcgcaa aatccaggca
      361 ttcagctcga tgctcacgcg agatttgcag gaccagctga cagataggtc gcgggattat
      421 attaggcgga tcaacaacgc aggggcgcgc atgtcggaac tgatcaatga tctgctggct
      481 ttctcgcgcg tttcaaccag acaacaacac cacgggctgg tctctctgga cgcggtaatc
      541 gctgacatac ttgtcaattt tgacctattg attgagcagc gcggggtgca aatcttgatc
      601 aatgagcttc cagtcgtgca aggggaccaa atgcagctgt cccagctatt tgaaaattta
      661 ctttcaaatg caatcaagtt cacaccacct gaccgcgttc ctaagatttc aatatccagt
      721 gaagtcattt catccggcca gctgcccgca ctaatacccg gccacgcagc cgtcaaggca
      781 tatcaccaga tctcggtcac ggatgaaggt atcggctttg acaccaagta ccttgacagg
      841 atctttcagg tatttcaacg tcttcacggg aaaggcgaat atcctggcac cggcgttggc
      901 ctggccatat gcaaaagggt ggtcgaaaat caccgcggtg aattgtatgc atccagtaca
      961 ctaggcaagg gagctacatt ctttgtctat ctaccaattg aataaaatca tttttgtgcc
     1021 tatgacgcgg caagacctat aactctttgc ggtaacccgt taccctgtgt atgggaaata
     1081 agaatggtcc taaaaagcat ctcctgctgg catgagattt tatacctggg tggaattttc
     1141 gttatgaccg actttgcaaa cttcaaccgc agacagagct atttccgccc ctatcaaacc
     1201 catctggatg tttacgccag gttgaaaaag gtggatttga aggcgatggc aacaggtaag
     1261 tggagttata aattcaaaat tttctgtttt ataccaatta tcctgttcca atgtgaatgc
     1321 gtcggatgta acatcctgat acatttaaac atgcccctgt taagaaaact cagcgcgaca
     1381 tcatggttag acacccgcca gctcactttt atgcttttaa tctcggacgc ttcacgtgat
     1441 aacgaagtac ttggtgccca aacaatcaaa atttcccagg ccgattctga cacgataaga
     1501 tcggcatgta aaagccaacg tactttttca tcaatgcaaa ttgaagacct ggttgatatc
     1561 atatatcaac ttgaaattgg aagcatatgg caaagctgac atttgttagt attgacttcc
     1621 ctaggagaag gaaatgataa agatcaaaat ctacgctgta acgcaaacat gattataaac
     1681 actgttcgaa tgcgaacatg tcaagaaaaa tatctctaag ctgcaaaagc tggacttggc
     1741 ccaaatcgta aaaatttgcc ttaaatcgcc tagcgctgtc cggaatgata acttgtcgag
     1801 ggggaactga caatttaact gtggcatagc tcctgttctc ggcctacatg ctacagtcgc
     1861 tccgtgattc gaggcagcaa ttcccctgca aagactattg atgacgactg gtttacatca
     1921 ggtcatccaa aatgattaat cgcattggca ttaacacgca acgccaattc aaaaaatgga
     1981 gtaaggtctc cacccttggg tggccatcta atcatgcggt tattcttagt tgctaattag
     2041 gcaataggcg ttgggcgaaa ctttttgcag cgctaatcta gccattaagt accggtgtaa
     2101 tgattagacc gctagtcggt aagttgatgg gggctatgac ttatgtggtt agcggttaag
     2161 gtttagcatt gcccagcgcc ccgaaggttg gcagaaaaca ctttctcggg attcattatt
     2221 ggcggtcatt cactttagta tgcctctgct cctcacacac ccggcgttca ccgacgggag
     2281 ctatattgac gctgcccaat acgtatactt ttggtctcgc taatttcagg aaccgctgga
     2341 attgtctgct cgcggtctgt ttcgatcgca ctcctattca ataatcaaat cacaccagag
     2401 gcaggcgcac ttacttcacc atgatcagac acaatggtcc ctccctatat ctgcttcagc
     2461 attgcatagc cagcaatacg ttagagcaaa gtcttggaat ttaaccagtc ttgtacagtc
     2521 taaccaaccc ttctgaatcc gcatggaaaa ggtcggccga atccacgccc agaatttgag
     2581 cgatctgaat gaggcgttcc aatgtgatac gggtatagcc gagctctatt ttgctgtaag
     2641 cgttctggga gatgcctagt ttcattgcaa gatactcctg cgtataatct ctgtactccc
     2701 tgattttcct gatattcaat gctactgacc taacccggaa acctattgat tcatccatga
     2761 aattgctggt ttgtttccaa tcaaaacttg ccgcggcaag ttcctatcgg aaacgtacga
     2821 ttaaaatacc aatcgtggat cgacacaaat acgaccttta agcaccaaat tatttgcaaa
     2881 atccagtaat aaataagaaa tgtcacacta accaactgag tatcaaagcg aaacaagtca
     2941 ccctcacaaa gcgtaaaagt tgatgggata accctaatcc cacccgacca atatttcaaa
     3001 atctttgttg cagacctagt ttctctgatt gtagacaaat aggtcactat ttttcaggtg
     3061 caaccatact tcacgcctgt cgtggccggt cgacagcccc cgacaaaagg ccaatgcatg
     3121 aaatctgcca aaaattgtcg ggaatagacc tcttgatagg tctccaatta cctgttcatg
     3181 gtataaggaa ccgcgtgcgt gatacgatgc cgatctgcat tcagatcatc tgcaatattc
     3241 ctgatagttg tattttactc ctttcagcta tttgattatc agccacttaa tcaactattg
     3301 gcacggtagt ttaaccacta tcaccgaacg caacgttcag caggggtagc cgaaaacctg
     3361 agaaagagta agctattttt aactaaattt tatgagttat gaaatttcaa gaattgaatg
     3421 cgactgaaat gaaagaaatt aatggcggtt tgttaggcct tggaaacagt agtgactctg
     3481 cctcttcggg cgggcttttc ggatcattgg gcgtggcctt cagcaacgaa tcagtggatg
     3541 atgacggctc ctcggaaaaa acccagttcg gattaggact tgatctggga ggaatattta
     3601 attctataac aggataagga attggataag tcaaaaaata gcgggggcag ctgaggttgc
     3661 ccccgttttt tggttcgaaa atgacacgca catggacaaa gatcacagca gtacccgcaa
     3721 caaaatattt ccgcccgaaa tactggaata cacatccgac tatcatttcc accagcatca
     3781 cacacgctcg aacttaatct atcagcttct gttgctgatc attatcgtgg gattcatttc
     3841 catgtttctc atcgcagttg atgtcagcgt cagaagtacg ggcattattc gcgcctccga
     3901 cgaccgcaat gaaatcaagg cgctggtgag cgggcggctc gattcggtat ttgttgccga
     3961 aaatcaacgc gttgaaaaag gacagacgtt gcttaaaatc gaggcggaga taatcaaaga
     4021 gcagaatcag cttgttaagg cccaaaaaac ggattttgac aatcagatcc gcgatctgaa
     4081 agtactattg catttgagcc ggaccaataa ctggagtaaa aaaccgggat tggtcagcgg
     4141 tttgtacaaa caggatttcg cgcttttctg gcaaaaaatc acggatgcca aaacgacgct
     4201 ccttactgtc gagaaggact ttgcacgaaa caagatcctg cacgacgtca aggcgatttc
     4261 cgaagccgaa tttgacaagg cggtactgct gcataccacg gccaagaacc gcatcaaaac
     4321 cattatggaa gaggaagagg cacgctggga gtccgaattg acccagctgc aaatgaaatc
     4381 ccgtgaactg aactcgcagg atcagcagta tctgcgcgag aaagattact atgtcgtaaa
     4441 agccccgatc agcgggacca tccagcagtt gaaaggacta cggccgggca gcattgtcgc
     4501 ttccaatgaa tttttagccg aaatatctcc cgatgaggcg atgatcgctg aaatgtatgt
     4561 gctgccgaaa gacatcggat taatccaccc gggtactctt accaggctgc aagtcgatgc
     4621 ctataactac aaccaatggg gcctggttac cggcagggta ctttcaattt ccaacgacgt
     4681 ttatacggac ggaaaacaac cgccgtactt taaggtacgc tgcaagttgg ataagagctc
     4741 tcttacatta aaaagcggct acgaaggtaa attgaagaag ggaatgacct tgcaggcgcg
     4801 ctttctggtt accgagcgca cattgtttca actgctctac gataaagcgg atgattggct
     4861 taacccgaac ctggtcgcca ctactgaaac cccacccctg aactgatcgc atgggaactt
     4921 ccggattttt gagtttatgg gcgaaaatcg ccgcattctt gaagcgcatt tctagcaaca
     4981 ttcctttctc acgcggcaga atgcgccgcg cggatgtggt tatcaagcag cacgacctga
     5041 cggactgcgg ggcgacctgc ctggcttcca tcgcggcctt ttataaattg acaatccctg
     5101 ttgcccgcat tcgccagtat gcttcgaccg accagaaggg cacgaacgtc ctggggctga
     5161 tagaagctgc gaccaagctg ggattcacgt caaaaggtgt gaaagccgac tttgaacaac
     5221 tacctcatgt acccgtgccc gtgatcgcgc acgtgattat caagcaggtc ttgcatcatt
     5281 atgtggtcgt ctacaacatc accggcagca cggtagaggt gatggaccct gcacggggtg
     5341 aaatcatccc tatgagttat gacgaattca gaagcatctg gaccggcgtg ctcgttttag
     5401 ttcagccagg cgatacattt ttggaaggga atgaaaaaat atctgttcaa aagcgattct
     5461 ggtacctgat aaaaccccat aacgctatac tcgtgcaggt tttgatcggc gctatcatct
     5521 ataccattct cggactttca acatctatat tcctccaaaa gatagtagac aatgtactac
     5581 cggaaggcaa ccgtaacctg ctgaacttga tgggcgtggt catgatcggt atcctgtttt
     5641 tcagaatcat tatcaaccat gccaaaacgc tgctcaccat caagaccggc cagcagatcg
     5701 acgcccggtt gatattaggc tattacaaac atttgctgcg cctgccacag cagttctttg
     5761 ataatatgcg cgtgggtgag attatttcca ggatcaatga tgcggtgaag atccgcgttt
     5821 tcatcaatga cgtcctcgtg gggtttgccg tgaacatgtt tatcctgctc ttctcgttcg
     5881 ttttgatgtt tacctattac tggaaactgg cgctcatcat gctatgtgtg gttcccctgt
     5941 atgcggtgat ctactttttc tccaaccgga tgaataaatc cacacaacgg aaactgatgg
     6001 aaagctccgc cgaactagaa gcgcagctgg tggaatccat ccattcggtt agtacgatca
     6061 aacggttcgg gctggaagat ttcactaaca tgcgcaccga aacacgcttt gtgggcatgc
     6121 tccgctctgt ttatgaatcc aacaccaatt cactctggat cggggatttc agtggttttg
     6181 ttgcgagtgc ttttactatt attttactct gggccggttc tcttttcgtg ctcaataaca
     6241 tcattacccc gggtgaactg ttatcgttct acgcaattat cgggtacttc actgggccgg
     6301 tatcgagcct gatcggcatg aataaaacca ttcaggacgc ctccattgct gccgatcgct
     6361 tgttcgagat catggacatc gaacgggaat cggtggaaaa taaagccata ctaacgcccg
     6421 acatgatcgg tgacatacat ttccgtaatg tccattttcg ctatggaacg cgggtgacgg
     6481 tatttgaagg acttgacctg gtgattccca aaaacaagat taccgccgta gtgggcgaaa
     6541 gcggctcggg aaagaccaca ctgctcgcgc tactgcaaaa catttaccct atcgaacaag
     6601 gaaacataca gctgggcggc ttcgacatca aatacctgac caacgacagt ctgcggcaaa
     6661 tggtgagcgc ggtaccccag gacgtacatt tgtttgcagg aaacgtgatc agcaatatag
     6721 ccgttggcga attcgagccg gatatgaaaa aaatcgtgtc catatgccag gaactggaca
     6781 tcatgaaatt tatcgaaaat ctcccgaatg gcttcaacac ctacatcggc gaaaacggca
     6841 ccagtctttc cggtggacaa cgacagcgat tggccattgc ccgggcgctg taccgcgacc
     6901 ctgagatatt gatcctagac gaagccacct cgtcgctgga ttcgaaatct gagcagcaca
     6961 ttcagctcgc gatccagtcg ctcagaaaga aaaacaaaac gatcatcatc atcgcgcatc
     7021 gacttagcac cgtcatgaat gctgacaaga tcgttgtact cgaacatggg aaactggttc
     7081 aagaaggcac ccataaaaaa ctcatcagtc aaaaggggcg atactttgac atgtgggaac
     7141 agcaattccc cacgctacaa aatgaaaagc catttgcaag atcaagaaat gggattaatt
     7201 cttcacccgg ctagaggcaa agcagccaga tgcttttcaa ttttcccaac aggacaagct
     7261 gcaccctaac aaatttgtac acaaaatacc ggttcatctg tctatatcat gcgagttaca
     7321 cgcaaatatc ccggtgggtg cgtaaccatt taaaacggga gcaaaacagc ctcctattct
     7381 aacatagacg gacggtgtat gataagccat cgacggcgta ggttgtcctc agaaaaaagg
     7441 gaaaccgatt caaattctac aaatagtgac aggtcggatt ttcccctatt cgacgcaatc
     7501 ccgcttcgct tccccggaga ctgccgttgt ccaatccgaa gcaaatggat ggacagatca
     7561 aacgaatgcc acctttaact gctactgcaa catactttcg atgtgacttg tagcttacct
     7621 attggataca gctcatcatt gataaaatat ccaggtccag gccaattgtt tccagttttt
     7681 gaacggctga ccgtcgcgct atagccatct cttcaagcgg taatgattga aaaaactagc
     7741 tgcttcgtta atagtcgatc catgttgcaa aaaataaacc ctgacctgta tttcgtcagg
     7801 gggacactgg tttccaaagc cagccgagca tcgtttacct ctcatttgac cgcagcagtt
     7861 ttaaacttgt caaacatttt gtcgatgtct gccctatcgt aatagatcac accgcctatc
     7921 cgcatgaaac tgagttgacg acttacacgc atcgcatgca gcttaccggg tgatacgtca
     7981 agtagcttcc ttacttcccg agatttgagc cattgcttcg aatgctgtgt gcctccacct
     8041 gagattagct ttctcatctc agagagcatt tgctccttaa atttttccaa atccgccaac
     8101 gtgactaatt gatgcgtgaa caacgctgaa cgctcctcta attgcttacc cttcttttcc
     8161 attgctgcct gctttacgtt aacaatcaaa aacatcgact gcgcgtatca atcgatgttt
     8221 ttgaccggaa aataatagtc agcacttgat actagcttcc tatttttcct gctggaacaa
     8281 aaggaataaa gtgccgttcg atgcgacccg catcgaacgg cactttgcct tcaataatct
     8341 gtgaagatat gaccttcgtg ttcgctgtat ccttctaaaa acaagtcttt agcgaaagct
     8401 tcgtagtcga agtaacgttc aatagcctgt ggcacgcctg acaacaaacc tgtgtcttcg
     8461 acatattggt aggcgtattc tagtgctgca tccttccctg aaacgccaaa gaatccttgg
     8521 tagctttccc ggaaaccttc tagctggtcg tccaattcat atccgttgga cggccagtag
     8581 ttaatctgct tacagtaaat attgaatgct tcggcagtct catcgtccat ttcaccggtg
     8641 gcttcaaagt aagcgaacgc ttctttatga aggctgcatt ctgatatcaa gaagtccggg
     8701 atgttttccc agtcttggaa catgagctct ggatccagtt catttcgatg aaattcaaaa
     8761 cagtcttgca gaaactcttt gcggtctaca tagtccgtca agtcaaacca tttaccgaag
     8821 agcgacccat tgttgtactg gccatatgtt cccacataga ttcttggaat atgttcgaga
     8881 tttctcatga ttgaaaggta tttaagtagc taaggccccg gctttgtgct caggacaatc
     8941 gctgccttcc actcaaagaa aaaatgacgg ggcttgcccc cctggttgca agcccatccg
     9001 gcggtttaag gtgcggctgg ctaatgcggg ttcagctaaa aagccggatg acgcagtgca
     9061 ggcttgcaac cgtcattttt tactttgtaa ctttcgtttg cactgatcgc attgttaact
     9121 tcgcctcccg ttcaagtatc gttctttccg cagtttatga gatgcccttt actgttatta
     9181 gcattttacc tattggctgc gttagcccat gcccagacac caaaggttga ctcgctggtt
     9241 atcgggaaat tgaaggacct gcatgttccg ggccttgccg cagcaaaggt tgaaaacggc
     9301 caagtttcct ggacgcacta taacggcttc caagacatgg agcagaaagt acccgtgaca
     9361 gattcaacgg tctttcacat agcctccatt tctaagacaa taacagctgc ggcggttatg
     9421 caactcgaag caaagggata tttcaaactg gatgatgaca taaacgggtt cctcccattt
     9481 cgcgttgtca atccatcgtt tccagctgct ccgatcacgt tcaggctact gttaaggcac
     9541 cgatcgtcga tagcggataa catggactat ctgcttccat tttggggaaa tacatatcag
     9601 ggagccgata ttccattggg cacattcctt gcggactatc tatctaccag tggcaagcac
     9661 tattatgcga ataagaattt taccggcgcc gaaccaggta gcaggttcga atactccaat
     9721 attggctttg cactgctagg ctatcttgtc gaacggattg cgaagatccc attcgaccag
     9781 tactgcaaag cgcatctatt caccccactc gaaatgcatc ataccaattg gtttttagag
     9841 ccatttcgat cagaccggct ggcagtacct tatgagtatt cggactcgct cggccggtat
     9901 gaaaaattgc cccagggtaa attcccggac tatcccgcag gtcaactccg ctgcacggta
     9961 agtgacctgg cgaagtttct tgcgtgctgg tcaaacgacg gatcgtatgc tggtaagcgt
    10021 gttattgaag ctaggtcagt acaacttttg acgccaatgg acatgagcct gggcttccac
    10081 acctggttta tgtatttgct caacacggag acacccacat acagtcatag cggacatggc
    10141 cctggtatct ccacctacat gctatatgac ccattttcaa aaaaagggct gattattttg
    10201 atgaacgggg agctttccga ttacttcgaa tggagaaaat tgattgattt actctggaag
    10261 tcctaaacat tcccaggcaa gtaactttac ttaaaaaaca gttcagatga tcaacagaaa
    10321 agcgctcctg gtaattgaca tgcaaaaggg ctcgtttaca gcagctaccc ctcgtcaaaa
    10381 caccgaagga gtcgtgcaaa taatcaattc gtttcgcgcg aaatcttggc cggtgttatt
    10441 tattcagcat gatggtagca caatgaacta gttcgtgccc tttactacgg agtgggaatt
    10501 gctggatgat ctaaaaattg atacagatga tatccgcatt gacaaatatg ccgacgatgt
    10561 gttctaccgc tcggaactcg ggcagaaact gggcgcccta gccattaacg aattggtcat
    10621 tacaggctgc gccacagact tttgcgttga atcgacgatt cagtcagcgg tttccaagga
    10681 ttatagcata actgtcatcg aagatgggca taccactggt aacagaccga gtctgagagc
    10741 ccatcaggtg attgatcact acaattgggt atggaagaac atgatcccta caaagggaaa
    10801 aattgaagtg ttaccccatc tcgagtttct tcaaaaattt gccatcagat gaatcaattt
    10861 cacttcattt attcttatgt agcggcgata caatcatctt cttcggataa gaacataaaa
    10921 gaatctatat cattcagaaa gcattcgaga taacatcaac ttcacttagg cctctcaatt
    10981 cttgaacgct gattgccaaa aagatcatga gaagaaactg acaaaaagac acacatctgg
    11041 tgaaaaattt tgcaattact atgtttaaaa cttcaatatt cgagaaaaag gttttccaat
    11101 aaaatcgaaa taaaccggct acaattcctt tacagaatta accagtgtaa gtaaaatggg
    11161 gtaacccgga attctatttg cattggtttt gagctcgtac gcaattagtc tccacaaatg
    11221 gttagtaatc cttaaaacct gtcagcacaa atctgaaaga aggaataaaa gaatgaaaga
    11281 aaatctcaat aactgtctga gatatttctt ttgccggcaa caattttacc atcaatcgcc
    11341 tcaggttgaa ttgagacgat tgatggatac tgcttacttc ggcatcaaaa ccgtatcgat
    11401 tacatgaatt accccgtttg actggaaaac atctgcaatt gtgaccattg cgaggtttcc
    11461 tttcgcgtct gtcaggacga tttttttgcc cttctgcata gcagtaagct ctccacctgc
    11521 aacggttttc aacattgctt taccaccacc attcttgatg gccttcatca ggtcggctgc
    11581 gctcatattg cctgctacca cgtggtaagt caaaatgccg gtcagcatct ctttgttttc
    11641 aggctttacc agcatatcca cggttccttt gggtagtttg tcgaatgcca tattggtggg
    11701 tgcgaacact gtgaacgggc ccgggccgga caaggtttca accaatccgg cggcttttac
    11761 ggctgcaacg agtgtagtgt gatcctttga attaacagcg ttttcaataa tgttcttgga
    11821 tgggtacatg ggcgccccac caacggttac ggttttttcc tgtgcgaacg aataattccc
    11881 aatcaccagc aatgtgatca gtgagagaaa gaaatttagc tttttcattg tgaaagtcag
    11941 cttgaaaagt gaacagttaa gtgtgtgtaa tcgatcaaca cgaccaatct acgcttgcct
    12001 atctgctttt ggatcactat gcattaatac tcaggtcaga aagagtgctt ttgatttgca
    12061 ataaactgat ttacggataa ttaattattt tcaaacacat acgtatacat caaaaacgta
    12121 tagcttctat ggacaaaacc aagaattggt tagagaaaat attttcattg gttttgatct
    12181 gatcctaaaa agtcggcgta agtcttgccg aaac
//
