LOCUS       NZ_JH636436.1          10921 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JH636436.1 Schlesneria paludicola DSM 18645 Scaffold3, whole
            genome shotgun sequence.
ACCESSION   NZ_JH636436
VERSION     NZ_JH636436.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:18:25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 542027
            Orig. end    :: 552948
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10921
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[547027:547948](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5921)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10921
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10921
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(461..1318)
                     /NRPS_PKS="Domain: PKS_KR (9-171). E-value: 4.6e-11. Score:
                     34.8. Matches aSDomain: nrpspksdomains_ctg3_433_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     194.8; E-value: 3e-59)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_433"
                     /sec_met_domain="adh_short (E-value: 1.4e-32, bitscore:
                     108.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKVIRGRKALVTGAASGIGRGIALALAREGADLTLWDVDETGLTS
                     LADEIKALGVCADTTRVDLTQPNEITAAVQLLLERSQTIDILVNNAGVAYYGPTHSMTA
                     AQWDWLLGINLLAPIQLTRELLPTLLERPEAHIVNVCSISGLVAGGRFAAYHTSKFGLI
                     GYSEALRAEYGRRGLGVTALCPGPCLTNLYRDCATGKQGKTVPHPPRWLCTTIDTVAAS
                     TIKAIRRNHRMPLIGPMAHLLWNIKWLAPGLLDFLNHFRRKRRTQPTGLISANDQQTAS
                     RHAA"
     PFAM_domain     complement(734..1297)
                     /aSDomain="adh_short"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00106.27"
                     /description="short chain dehydrogenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_433_0001"
                     /evalue="4.40E-49"
                     /label="ctg3_433"
                     /locus_tag="ctg3_433"
                     /protein_end="195"
                     /protein_start="7"
                     /score="166.7"
                     /tool="antismash"
                     /translation="KALVTGAASGIGRGIALALAREGADLTLWDVDETGLTSLADEIKA
                     LGVCADTTRVDLTQPNEITAAVQLLLERSQTIDILVNNAGVAYYGPTHSMTAAQWDWLL
                     GINLLAPIQLTRELLPTLLERPEAHIVNVCSISGLVAGGRFAAYHTSKFGLIGYSEALR
                     AEYGRRGLGVTALCPGPCLTNLYRD"
     aSDomain        complement(806..1291)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg3_433_PKS_KR.1"
                     /evalue="4.60E-11"
                     /label="ctg3_433_PKS_KR.1"
                     /locus_tag="ctg3_433"
                     /protein_end="171"
                     /protein_start="9"
                     /score="34.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVTGAASGIGRGIALALAREGADLTLWDVDETGLTSLADEIKALG
                     VCADTTRVDLTQPNEITAAVQLLLERSQTIDILVNNAGVAYYGPTHSMTAAQWDWLLGI
                     NLLAPIQLTRELLPTLLERPEAHIVNVCSISGLVAGGRFAAYHTSKFGLIGYSEALRA"
     CDS_motif       complement(1226..1291)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg3_433_0001"
                     /evalue="4.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg3_433"
                     /protein_end="31"
                     /protein_start="9"
                     /score="12.9"
                     /tool="antismash"
                     /translation="LVTGAASGIGRGIALALAREGA"
     CDS             complement(1387..2832)
                     /locus_tag="ctg3_434"
                     /transl_table=11
                     /translation="MTRMSFVLLLATWLTIGCTSDPMGMRSSYRDRNVAPSAVQQPYNR
                     APVAAQPGMQGAQFGQPGGMTQSAILPQAALTNMQVAQAQGARLNGVSPYPMVASAGGQ
                     FDGRDYQLLSGPAQPPRISGRIHRMNGMQSSAIANGIPPTPQEDLKYRGGRTIKDLKFI
                     NLYVGGSAAWAANDWKSIDKALAAAMTDQNLNNVIMQYFGNKPISNQFLGSFFVDGWNP
                     KNVTKNDLETQVQYLYRQKAFDGQDLPNLVVNFMLPRGTILADPNSGQQTAVLNKAIPQ
                     EEAEDSTGGLGGYHGSAHIDGKTIYYAVGVYSERQANNKTNGIPVFDANWKNVVATFYH
                     ELQEARTDPDVDDAITANTMSVLGWTSDSGQEIGDYPISEAPQLMLVFKEVPLTNGSGT
                     VPIQLQYSNAVHGPEGPIPYPHGMEPGPGDQTPSNPPANNNPPTNPGSSLPANLPPQVV
                     DMVNNWDRLDDYVRKGILKLLAP"
     CDS             complement(3004..3819)
                     /locus_tag="ctg3_435"
                     /transl_table=11
                     /translation="MGAHVWNARTIFAAAILLGAAASTNGWSGEPVEDLLAATFRLTDG
                     EHSGTCFIVSVPAASATVPHKCVLATAAHVLDQMDADECDLILRSRTVDDCYVRKVVSI
                     KIREGQRDLWTAHPDLDVAAMPIDLPADATVAPIPFELIADESQLINRTIRVGQETWIS
                     CFPAKLESNEAGWPVLRRGSIASHPLIPLKANKTILIDYKVFGGDSGAPIATIVNNRPL
                     IVGVASSMQQQTDRSTLPFEERVMHTPMGLSIAVQSAYLRDTITQMQQK"
     PFAM_domain     complement(3115..3648)
                     /aSDomain="Trypsin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00089.28"
                     /description="Trypsin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_435_0002"
                     /evalue="1.10E-04"
                     /label="ctg3_435"
                     /locus_tag="ctg3_435"
                     /protein_end="235"
                     /protein_start="57"
                     /score="22.2"
                     /tool="antismash"
                     /translation="AASATVPHKCVLATAAHVLDQMDADECDLILRSRTVDDCYVRKVV
                     SIKIREGQRDLWTAHPDLDVAAMPIDLPADATVAPIPFELIADESQLINRTIRVGQETW
                     ISCFPAKLESNEAGWPVLRRGSIASHPLIPLKANKTILIDYKVFGGDSGAPIATIVNNR
                     PLIVGVASSMQQQTD"
     CDS             complement(4064..4954)
                     /locus_tag="ctg3_436"
                     /transl_table=11
                     /translation="MPDASSSTDQRPLRDIQSWMQVVVTHPDGIRAGMIAAEAVSGIPQ
                     GDAERIILPSSQMTSHERLQIYNRAYFGRLIECLRAQFPAVRHAVGNDAFDGLAFGYLL
                     QHPSTSYTLDRLSQSFDEFLTSTRPPRTMKPDFADFAIELARLERVYNEVFNGRGPESA
                     RSLEPADFEGLSPERFASSRLIAHDCVRLMEFQFPVHEYTSALRRGQPALPPEPRSVLL
                     VITRRNYVVRRYEVARDQFELLTILQQQKTVAEALDRLAEIRHDDLSSLANDIRNWFRD
                     WAAAPLFAKLVTSDS"
     PFAM_domain     complement(4583..4906)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_436_0003"
                     /evalue="3.20E-19"
                     /label="ctg3_436"
                     /locus_tag="ctg3_436"
                     /protein_end="124"
                     /protein_start="16"
                     /score="69.1"
                     /tool="antismash"
                     /translation="QSWMQVVVTHPDGIRAGMIAAEAVSGIPQGDAERIILPSSQMTSH
                     ERLQIYNRAYFGRLIECLRAQFPAVRHAVGNDAFDGLAFGYLLQHPSTSYTLDRLSQSF
                     DEFL"
     CDS             complement(5001..5921)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_437"
                     /sec_met_domain="DUF692 (E-value: 2.2e-90, bitscore: 298.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASRLGYDNVGLGVGLRTVHFDHILNHAPPVDWFEVISENFLDSW
                     GRPRYVLEQIAERYPVVMHGVSLSIGSTQPLDFDYLRKLKQLARDTKALWVSDHVCWTG
                     VAGINTHDLLPLPYNEQSLAHVVERIRIVQDVLERPLVLENPSSYVTFADSTMSEAEFL
                     SRMAEDGNCGLLLDVNNVYVSAQNHEFDPVEYLRAIPHHRVVQMHLAGHTHCGTHLIDT
                     HDGPVINPVWDLFRLAHELTGGVSTLLEWDAQIPEFPVVHNEILKAKQILAGELAPEPK
                     ADLPRSPQQYPTVPHPALVVTAQAD"
     PFAM_domain     complement(5106..5891)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_437_0004"
                     /evalue="1.40E-105"
                     /label="ctg3_437"
                     /locus_tag="ctg3_437"
                     /protein_end="272"
                     /protein_start="10"
                     /score="352.3"
                     /tool="antismash"
                     /translation="GLGVGLRTVHFDHILNHAPPVDWFEVISENFLDSWGRPRYVLEQI
                     AERYPVVMHGVSLSIGSTQPLDFDYLRKLKQLARDTKALWVSDHVCWTGVAGINTHDLL
                     PLPYNEQSLAHVVERIRIVQDVLERPLVLENPSSYVTFADSTMSEAEFLSRMAEDGNCG
                     LLLDVNNVYVSAQNHEFDPVEYLRAIPHHRVVQMHLAGHTHCGTHLIDTHDGPVINPVW
                     DLFRLAHELTGGVSTLLEWDAQIPEFPVVHNEILKAKQIL"
     CDS             complement(5940..7085)
                     /locus_tag="ctg3_438"
                     /transl_table=11
                     /translation="MRPFIVGIGIGGVMGCLLATTPAWAQNPITSRTGDSPQKLPKSKN
                     AAKTTLVEFEVLQESDAAAIYAQHWLKILGPLDVSLRIHRPTSNDKPEIKERTIGTLRY
                     VTAIGTLDRNGKINFPDNSFAVGDANKLKDWITELRTYGAQGTPTGRPLWGLTKEQFAE
                     IYEALVKPVEFETEGLPLDQFVSKLPLPNQFPLRWSPDAKTKLPQSADKIKIRQDLTGF
                     SAATALAVGIGESRLGFRPNRTPGGDVELLIEPIPAKQELWPVGWPLQRQNFKAAPKLF
                     AVSVIDLEDIELVDVLNAIATSADTPILVDDAELRAAKLDIEKMKVSFPRKNSNWNLAL
                     TRMLATQKLKHELWQDEAGRTFVWITTPRAVRAKDPDISTP"
     CDS             complement(7293..7817)
                     /locus_tag="ctg3_439"
                     /transl_table=11
                     /translation="VNLKDYIRSVPNFPNPGIMFRDITPLLSAPEAFGFAIRQFADRFR
                     AAKPTAILAAESRGFIFAAPLALELGAAFVPVRKPGKLPFETRKFEYDLEYGSDALEMH
                     VDAIHSGSRVLLVDDLLATGGTIEACVKLAEGSQAEVVGCAFLIELSFLKGRDRLKNHD
                     VFSLMQYDSED"
     aSDomain        complement(7308..7811)
                     /aSDomain="TIGR01090"
                     /aSTool="tigrfam"
                     /description="apt: adenine phosphoribosyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_439_0001"
                     /evalue="6.50E-66"
                     /identifier="TIGR01090"
                     /label="ctg3_439"
                     /locus_tag="ctg3_439"
                     /protein_end="170"
                     /protein_start="2"
                     /score="219.6"
                     /tool="antismash"
                     /translation="LKDYIRSVPNFPNPGIMFRDITPLLSAPEAFGFAIRQFADRFRAA
                     KPTAILAAESRGFIFAAPLALELGAAFVPVRKPGKLPFETRKFEYDLEYGSDALEMHVD
                     AIHSGSRVLLVDDLLATGGTIEACVKLAEGSQAEVVGCAFLIELSFLKGRDRLKNHDVF
                     SLMQY"
     PFAM_domain     complement(7359..7703)
                     /aSDomain="Pribosyltran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00156.29"
                     /description="Phosphoribosyl transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_439_0005"
                     /evalue="5.10E-14"
                     /label="ctg3_439"
                     /locus_tag="ctg3_439"
                     /protein_end="153"
                     /protein_start="38"
                     /score="52.0"
                     /tool="antismash"
                     /translation="QFADRFRAAKPTAILAAESRGFIFAAPLALELGAAFVPVRKPGKL
                     PFETRKFEYDLEYGSDALEMHVDAIHSGSRVLLVDDLLATGGTIEACVKLAEGSQAEVV
                     GCAFLIELSFL"
     CDS             8087..8845
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1279:pseudouridine synthase (Score: 181.6; E-value:
                     3.5e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_440"
                     /transl_table=11
                     /translation="MTNEPAASGTPYTNLSSRPLEILLDDGPLIALNKPAGLLTQGVPH
                     AQASMEGLVKAYLKTKLDKPGNVYLGVPHRLDRPVSGVVIFAKNSKAAARLAEQFRERS
                     LRKIYLAVTEGVPDPAEGCLVDWLFKDAEDAHVTVVPAGTPGAKRAVLDYQVLAVHQGR
                     ALVEVELHTGRMHQIRVQFGSRGWPIADDRQYGSKSPATLSDYDPRVSPIGLHAWRLHL
                     RHPVRYDALRLEAPLPANWSRFGFKLPKGI"
     PFAM_domain     8171..8632
                     /aSDomain="PseudoU_synth_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00849.24"
                     /description="RNA pseudouridylate synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_440_0006"
                     /evalue="5.60E-34"
                     /label="ctg3_440"
                     /locus_tag="ctg3_440"
                     /protein_end="182"
                     /protein_start="28"
                     /score="117.6"
                     /tool="antismash"
                     /translation="LIALNKPAGLLTQGVPHAQASMEGLVKAYLKTKLDKPGNVYLGVP
                     HRLDRPVSGVVIFAKNSKAAARLAEQFRERSLRKIYLAVTEGVPDPAEGCLVDWLFKDA
                     EDAHVTVVPAGTPGAKRAVLDYQVLAVHQGRALVEVELHTGRMHQIRVQF"
     CDS             8946..10430
                     /locus_tag="ctg3_441"
                     /transl_table=11
                     /translation="VSCKLLGILAVLFVSSFLIAPVALAEVAGADVTQAADHSTEKLGD
                     LLNPIAVLPFVILLLCIALFPLLNPHWWEHNRNKGIIALVLGVPVVGYLMTFGHHGLEA
                     MEHAGKEYVAFLLLLGSLFVISGGIYVRGALRGSPAINTMFLGLGALIASFVGTTGASM
                     LLIRPLLRANGHRHRVAHIVVFFIFVVSNCGGLLTPLGDPPLFLGFLKGVPFGWTLRLF
                     PQWAFVNGTLLVIFYLWDTLAVRSEAKTPEQEAALEEPLTTESFGIEGRHNFLGLAVIV
                     AIIYSCGQGYGNAFFKQYLPGDGEVWPFGVQELLMALTTAICFLFTSRGTHEKNRFGFG
                     PIIEVAVLFAGIFVTMIPALALLNVHGKSLGVDDPAEFFWAAGILSSFLDNAPTYLTFA
                     ATACGMYGVNTEDGRYLHHFLNLPEAAQTARILAAISCGAVFMGANTYIGNGPNFMVKA
                     IAEENNVKMPGFFGYMAYSMGILIPIFIAVTFIFFR"
     PFAM_domain     9093..10424
                     /aSDomain="CitMHS_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF16980.7"
                     /description="Putative citrate transport"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_441_0007"
                     /evalue="2.40E-158"
                     /label="ctg3_441"
                     /locus_tag="ctg3_441"
                     /protein_end="493"
                     /protein_start="49"
                     /score="527.6"
                     /tool="antismash"
                     /translation="IAVLPFVILLLCIALFPLLNPHWWEHNRNKGIIALVLGVPVVGYL
                     MTFGHHGLEAMEHAGKEYVAFLLLLGSLFVISGGIYVRGALRGSPAINTMFLGLGALIA
                     SFVGTTGASMLLIRPLLRANGHRHRVAHIVVFFIFVVSNCGGLLTPLGDPPLFLGFLKG
                     VPFGWTLRLFPQWAFVNGTLLVIFYLWDTLAVRSEAKTPEQEAALEEPLTTESFGIEGR
                     HNFLGLAVIVAIIYSCGQGYGNAFFKQYLPGDGEVWPFGVQELLMALTTAICFLFTSRG
                     THEKNRFGFGPIIEVAVLFAGIFVTMIPALALLNVHGKSLGVDDPAEFFWAAGILSSFL
                     DNAPTYLTFAATACGMYGVNTEDGRYLHHFLNLPEAAQTARILAAISCGAVFMGANTYI
                     GNGPNFMVKAIAEENNVKMPGFFGYMAYSMGILIPIFIAVTFIFF"
ORIGIN
        1 acgcgattat tgatgaagcc accaacgccg accgtgatct tcctggcgta gcggagtgat
       61 tggattccgt gacggttggt gtcctgttga aatcaacagg acaggcacct tgattctcac
      121 gacatcatag gcgtcgtcga atccgcgtag gaccagcccc tgttattggt cgctacggtg
      181 attgaagttg gtctacacaa ctggcgtgat ctttctgaga tcgcgccaaa ttaccttgaa
      241 tcacattcaa tcgtttcgcc cggagccagc ggcgacaaag ttttgcgatc ctgcaaagca
      301 attccgaatg acgtgtgcat tgcctcattc gctgccagtt ggcttccggg atcgcaacta
      361 gaaattccca ccagcgagtc cgaagaccgc ttctcttcga ggcgtgactg ggatagccga
      421 cgagggtgat tcgcgtgtct cacgctcctc aatacgccct ttatgccgca tgacgggatg
      481 ccgtctgctg atcgtttgct gagatcaatc ccgttggctg tgttcgacgt ttcctgcgga
      541 agtgattcag gaaatcgagc agacccgggg cgagccactt aatgttccac agcagatgag
      601 ccatcggtcc aatcaaaggc attcggtggt ttcggcggat cgccttgatg gtgctcgccg
      661 cgactgtgtc gatcgttgtg cacagccatc ggggtggatg gggaacggtc tttccctgct
      721 ttccggtggc gcagtcgcga tacaggttcg taaggcacgg gccggggcac agcgccgtta
      781 cacccagtcc gcgacgaccg tattccgcgc gaagcgcctc ggaatatccg atcaaaccga
      841 acttgctggt gtgataggcg gcgaatcgtc cacccgcaac gagtccagaa atactgcaca
      901 cattgacgat gtgtgcttcc ggacgttcaa gcagcgtcgg cagcagttcg cgtgtaagct
      961 ggatcggcgc cagcaggtta atacccagca accagtccca ttgcgcggcg gtcatcgagt
     1021 gggttggccc gtagtaggca acacccgcgt tgttcaccag gatgtcgatc gtttgcgatc
     1081 gctcaaggag taactggact gccgcggtaa tctcattagg ttgcgtcagg tcgacacgtg
     1141 tcgtgtcggc gcagactccc aaggccttga tctcgtccgc aagcgatgtc agccctgttt
     1201 cgtcgacatc ccacagggtg agatccgcac cctcacgcgc cagggccaat gcaattccac
     1261 gtccgatccc cgaagccgcg ccggtaacga gggccttccg gccgcgaatg actttcactt
     1321 ctggatgtcc ttacgaagct cggaatgcgg attgttccgg aatacgggta atttcatgtg
     1381 cagacgtcac ggtgctagca atttcaggat gccttttcgc acgtaatcat ccagccgatc
     1441 ccagttgttg accatgtcca caacctgcgg tggcaaattc gcgggcaggc tggaaccggg
     1501 gttcgttggt ggattgttgt tcgccggcgg attgcttggt gtttgatctc cggggccggg
     1561 ttccattccg tggggatagg gaatggggcc ttcggggccg tgtacggcat ttgagtattg
     1621 caattgaatc ggtacggttc cacttccatt ggtcagcggt acttctttga agaccaacat
     1681 caattgaggg gcttcggaga tcgggtagtc gccgatttcc tgaccgctat ccgacgtcca
     1741 acccagtacc gacatcgtat tggccgtgat ggcgtcgtcg acatccgggt cggtacgggc
     1801 ctcttgaagc tcgtgataga acgtggcgac gacgtttttc cagttggcat cgaacacggg
     1861 gattccgttt gtcttgttat ttgcctgacg ttctgagtac acgccgaccg cgtagtagat
     1921 cgtcttgccg tcgatgtgtg cagagccgtg atatccgccc agaccgccag tggaatcttc
     1981 ggcctcttcc tgtggaatgg ctttgttcag cacggccgtc tgctggccgc tgttcggatc
     2041 ggccagaatg gttccgcgag gcagcatgaa gttgacgacc agattcggta gatcctgtcc
     2101 atcgaatgct ttctggcgat agagatattg gacctgcgtc tccaggtcgt tcttggtgac
     2161 gtttttagga ttccagccat cgacgaaaaa tgatcccagg aactgattac tgatcggctt
     2221 attgccgaag tactgcataa tgacgttgtt caggttctgg tctgtcatcg ccgcggcgag
     2281 cgccttgtcg atgcttttcc agtcgttggc ggcccaggct gctgatccgc ccacgtagag
     2341 gttgatgaat ttcaggtctt taatcgtgcg accgccgcgg tatttcaagt cctcttgtgg
     2401 tgttggcgga atcccgttcg caattgcgga actctgcatc ccattcatcc gatggatacg
     2461 cccgctaatt cgcggcggtt gcgctggtcc tgagagcaat tgatagtcgc ggccatcgaa
     2521 ctggccacct gcgctcgcaa ccatgggata ggggctcacc ccgttcagcc gggctccctg
     2581 agcctgggcg acttgcatgt tggtgagagc ggcctggggc agaatcgcag attgcgtcat
     2641 gccgccgggc tgaccgaatt gcgctccctg cattccaggc tgagccgcga cgggcgccct
     2701 gttgtacggt tgctgaacag cagacggcgc gacgttgcgg tcgcgatagg atgaccgcat
     2761 ccccatcggg tcgctggtgc agccaatcgt cagccatgtc gccagcagca agacaaaaga
     2821 catccgtgtc attgatacgc ccctcacgta atccgatcct gccttggatc ggcggttttg
     2881 gccggtaaat atcagaaccg tccaaagctg gaaaggcgac ttttgccgaa gacaagcttg
     2941 ccgaaagtcc gggttgtcac actgcggagg ttaattggaa tgggtgaagt cgatgtgaag
     3001 ccatcacttc tgctgcatct gcgtgatggt gtcacgcaga tacgcagact gcacggcaat
     3061 ggatagtccc atgggggtgt gcatgactcg ttcttcgaag ggcagagtcg atcggtcggt
     3121 ctgctgctgc atgctggacg cgacaccgac aatgaggggg cggttgttga cgatcgtcgc
     3181 gatgggagct ccgctatcac cgccgaaaac tttataatcg atcaggattg tcttattggc
     3241 cttcagagga atcagtggat gagaggcaat cgaacctcgt cgcagcacag gccaccctgc
     3301 ttcgttcgac tccagcttgg cggggaagca actgatccag gtctcctggc cgacgcgaat
     3361 cgttcgattg atcaattggg actcatcggc gatcagttcg aagggaatcg gtgcgactgt
     3421 tgcatccgca ggcagatcga tcggcatggc agcgacatcc aggtcaggat gtgcggtcca
     3481 caaatcccgt tgtccctccc gaattttgat cgagacaact ttccgtacat agcaatcatc
     3541 caccgtgcgg ctgcgcaaaa tcagatcgca ttcgtcggcg tccatttgat ccagaacatg
     3601 cgccgcagtg gcgagcacgc atttgtgggg cacagtggcg cttgcagcgg ggacagacac
     3661 gatgaaacag gtccccgagt gctcgccgtc cgtcaggcga aacgtcgcgg cgagtaagtc
     3721 ttcgacgggc tcgccagacc atccgttggt tgaggctgcc gctccgagga gtatggctgc
     3781 tgcgaaaatc gtccgtgcat tccacacgtg agcccccatt tcgtgaatga agcttcctgc
     3841 ttgagaatga cgagcgcgcg tctcagtgaa agtaccggca gaccgtgatt ttggcgagct
     3901 gagttgcttc gctggtcaaa ttcgtttcgc ccagagccaa tagtgaaggt cgttttcgta
     3961 aagctgacaa gcggcatcga aacgcatatt tcacttggga tggcatgggt gaacagattg
     4021 cagggagagg aattcctgca cgtgcgcgat ccactgattc gaatcacgaa tcgctggtga
     4081 cgagtttcgc aaacagcggt gccgcggccc agtcccgaaa ccagttccga atgtcatttg
     4141 ccagcgacga caaatcgtcg tggcgaattt cggcgagacg gtcgagtgcc tcggcaacgg
     4201 ttttctgttg ttgcaatatg gtcaggagtt caaactggtc tcgggcaact tcgtatcgcc
     4261 gcacgacgta attccggcga gtgatgacca gtaataccga acgtggttct ggtggcagcg
     4321 caggctgacc tcgccgcaat gcgcttgtgt attcgtggac tggaaactga aactccatca
     4381 gtcgaacaca gtcatgggcg atcagacggc tgcttgcgaa gcgttcgggg gacagtcctt
     4441 cgaaatcggc gggctcaagc gatcgggccg attccggtcc acgtccgttg aagacttcgt
     4501 tgtaaactcg ctcgagccgc gccagttcaa tcgcaaaatc ggcgaagtcc ggtttcatag
     4561 tccgcggtgg acgggtggag gtcagaaact catcaaagga ttgactgagc cgatcgagcg
     4621 tatagcttgt cgagggatgc tgcagcagat agccaaatgc caatccgtcg aatgcgtcgt
     4681 tgccgaccgc atggcggacc gcagggaact gagcccgcaa acattcgatc aagcgaccaa
     4741 aataggctcg attgtaaatc tgcagtcgtt cgtggctggt catctggctg gagggaagaa
     4801 tgatccgttc ggcatcaccc tgcgggattc ctgagacggc ttcggcggca atcattcctg
     4861 cacggattcc gtcggggtgg gtgaccacca cctgcatcca ggattgaatg tcgcgcagtg
     4921 gtcgctgatc ggtggaagaa gatgcatcgg gcatgggggt gttcgtcgat cgtgatggaa
     4981 tcgcgtgctg gcggcctggt tcaatctgcc tgggccgtca cgaccagagc agggtgagga
     5041 accgtcgggt actgttgggg cgaacggggg agatcggctt taggttcggg ggcgagctca
     5101 ccggccaaga tttgcttggc tttcaagatt tcgttgtgga caacagggaa ttcggggatc
     5161 tgcgcgtccc actccaacag agtcgagaca cctcctgtga gttcatgggc caggcgaaat
     5221 agatcccaaa cgggattgat caccgggccg tcatgggtat cgatcagatg tgtgccgcag
     5281 tgggtgtgcc ccgcgagatg catctggacc acacgatgat gtgggatcgc acggaggtat
     5341 tccacaggat caaactcatg attctgggca gagacataga cattgttgac gtccagcaac
     5401 agcccgcaat ttccgtcttc tgccatccgc gagaggaatt cggcctcgct catggtggag
     5461 tcggcgaaag tgacgtagct actggggttc tccaggacca gcggtcgttc caacacgtct
     5521 tggacgatcc ggatacgctc gacgacgtgc gccaatgatt gttcgttgta gggcaggggc
     5581 agcaggtcgt gtgtattgat ccccgcaaca ccggtccagc agacatggtc tgaaacccat
     5641 agggctttcg tgtctcgggc cagttgcttc agcttccgca agtagtcgaa gtcgagcggc
     5701 tgcgtgctgc cgattgagag cgacacaccg tgcatgacaa ccgggtagcg ttcagcgatc
     5761 tgttccagca cgtatcgggg gcgtccccag gaatcgagaa agttctcgga gatcacttcg
     5821 aaccagtcga cgggcggcgc atggttgagg atatggtcga agtgaaccgt tctcaggcca
     5881 acccccaagc caacattgtc atatccaagg cgactggcca tcaagccact accgtttctc
     5941 taaggtgtcg aaatgtcggg gtctttcgca cgcacagcgc gcggtgtcgt gatccagaca
     6001 aaagtgcgac ctgcttcgtc ttgccacaat tcatgcttga gtttctgcgt tgccagcatc
     6061 cgtgtgagtg ccaggttcca gttgctgttc ttgcgtggaa acgacacctt catcttttca
     6121 atgtcgagtt tggcggcccg cagttccgca tcgtcgacca gaatcggcgt gtccgccgat
     6181 gtcgcgatcg cattcaggac atcgaccagt tcaatatctt ccaagtcgat gaccgacacg
     6241 gcgaacagtt ttggtgcggc tttaaagttt tgacgttgca gcggccaccc cacaggccac
     6301 agttcttgct tggcgggtat cggttcgatc aaaagttcga catcgccgcc gggtgttcga
     6361 ttcgggcgaa aaccaagtcg actttcacca attcccacgg ccagggccgt ggccgcgctg
     6421 aagcctgtca gatcctgacg gatctttatt ttgtcggctg actgcggcag ctttgttttg
     6481 gcgtcggggg accagcgcaa tgggaactgg ttgggcaaag gaagcttgga gacgaattga
     6541 tccagcggca ggccctcagt ctcaaactcg acaggcttca cgagggcttc gtagatttcg
     6601 gcaaattgct ccttggtcaa tccccacagt gggcggccgg tcggagttcc ctgagcgcca
     6661 taggttcgta gttcggtgat ccaatctttc agcttgttcg catcgccgac agcgaacgaa
     6721 ttgtcgggga agttgatctt gccgtttcgg tcgagcgtgc cgatggctgt cacgtatcgc
     6781 aaggttccga tcgttcgttc tttgatttcc ggtttgtcgt tcgatgtggg gcggtggatg
     6841 cgtaacgaaa catccagcgg gccaagaatt ttcagccagt gttgcgcata gatcgccgca
     6901 gcatcggatt cttgcagcac ttcgaattcg acaagggttg tctttgctgc attcttgctc
     6961 ttgggcaatt tctgcgggga atcgccggta cgggacgtga ttggattctg ggcccatgcc
     7021 ggagttgtgg caagcaggca acccatgacg ccaccaatcc cgattccgac gatgaagggt
     7081 cgcatgattc gctccgccgt agacgattgc catccctgct cacgccgcca ggaggaagac
     7141 tcccatgatt catggaacgt acggttcccg gcgcacgcgt cgacatcgtc atcgtaggtg
     7201 agcaggttcg tccatcacaa ggcctgttgc gcaggccttg tggaacagac aacagatgga
     7261 aatttgcgga gaatcgatct caggcgtggc ggttagtctt cgctgtcgta ctgcatcaga
     7321 ctgaaaacgt catgattctt gagccgatca cggcccttga gaaacgacaa ttcaatcaag
     7381 aaggcacatc cgacgacttc ggcctggctg ccttccgcga gcttcacgca ggcttcgatc
     7441 gttccgccag ttgcgagcag atcgtcgacc agcaataccc ggctgcccga atggatcgca
     7501 tcgacatgca tctcaagtgc gtcgctgcca tattcgagat cgtattcgaa tttgcgtgtt
     7561 tcgaacggca gcttgccagg tttgcggaca ggcacaaagg cggcgcccaa ttccaacgct
     7621 aatggggcgg caaaaatgaa cccgcgcgat tccgcagcca gaatggcggt cggcttggcc
     7681 gctcggaacc tgtcggcaaa ttggcggatc gcaaatccaa atgcttcggg ggccgaaagg
     7741 agcggtgtga tatcgcgaaa catgattccc gggttgggga aattgggcac actacggatg
     7801 taatccttca aattcacgaa atacgtcctt cttgcacagg gcttcgcgtt cgatcaacga
     7861 tccagttatt ccattttgac cgtaagactc tgttgaaact gggtgcgaaa agcaaccgaa
     7921 gctgtcgaca tgccttgaca tcaagtcgaa tagcgtgcga atgacacgcg tgtttgcctt
     7981 ttgagatgag ggtgatccca cgatgttggg gtgacgtatt gggatgtgta agagtgaagc
     8041 ttgttaggca ttcccgatgg cttccactgc ctgttaggat accgccatga ccaacgaacc
     8101 cgcagcctct ggcactccgt acaccaatct ttcctcaaga cctctcgaga ttctgctcga
     8161 cgacggtccg ctcattgctc tgaacaagcc cgcaggcttg ctgacgcaag gggttccgca
     8221 tgctcaggca tcaatggagg gcctggtcaa agcgtatctc aagacgaagc tcgataagcc
     8281 cggtaatgtt tatcttgggg ttccacatcg gttggatcgt ccggtgtcgg gggtggtgat
     8341 cttcgcgaag aattcgaagg cggccgcgcg actggcagaa caatttcggg agcgatccct
     8401 gcggaagatc tacctggccg tgactgaagg cgttccggac ccggcggaag ggtgtctggt
     8461 cgactggcta ttcaaggacg ccgaggatgc acatgtgaca gtcgtccctg ccgggacacc
     8521 aggagccaaa cgtgcggtgc tggattatca agtactagct gttcatcaag gccgcgcact
     8581 ggtcgaagtt gaactgcaca cggggcgaat gcatcagatt cgagtgcaat ttggctcgcg
     8641 cggctggccg attgccgatg atcgccagta tggatcgaaa agtcccgcga cgttgagcga
     8701 ctatgatccc cgggtttcac ccattggcct gcatgcctgg cgattgcact tgcgacatcc
     8761 cgttcgttac gacgcattgc ggctggaggc acctttgccc gccaattggt cgcgattcgg
     8821 tttcaagcta ccgaagggaa tttaatctcc cgatgctgca agacgtcgtc gctcgacttt
     8881 gatgatcgct tccgtttgaa tgtggtcgct cgcccgcatc gtgactctaa ttatcgagtg
     8941 ccatcgtgag ttgtaagttg cttgggattc tcgcggtttt gttcgtcagt agctttctga
     9001 ttgcgcccgt cgcactggca gaggttgcag gggcggacgt gacccaggcg gccgatcatt
     9061 cgacggaaaa actgggagac ttgctgaatc cgattgccgt gctgcccttc gtcattctgc
     9121 tgctgtgcat tgccttgttt ccattgctga acccacattg gtgggagcac aatcgaaaca
     9181 aggggattat tgcactggtg ctcggcgtgc ctgtcgtcgg gtatctgatg acctttggtc
     9241 atcacggtct ggaggcgatg gagcacgcag gcaaagaata cgtcgctttt ctgctcttgc
     9301 tgggatcgct gtttgtcatc agcggcggta tctatgtccg cggtgccttg cgcggttcgc
     9361 cggcgatcaa cacgatgttt ctcggtctgg gagctctgat tgccagtttc gttggaacga
     9421 ccggcgcttc gatgctcttg attcgcccgt tgttgcgtgc gaacggtcat cgtcaccgcg
     9481 tggcgcacat tgttgtgttc tttattttcg tggtgtccaa ctgcgggggg ctcttgactc
     9541 ctttgggcga tcctccattg ttcctcggct tcctgaaagg ggtgccgttc gggtggacgc
     9601 tgcgtctgtt tcctcagtgg gccttcgtga acggtacgct gttggtgatc ttctacctgt
     9661 gggacaccct tgcggttcga agcgaggcca agacacctga acaagaagcg gccctggaag
     9721 aaccgctgac gacggaatcg tttggaatcg aagggcggca caattttctt gggttggccg
     9781 tgattgtggc catcatttat agctgcggcc aagggtatgg aaatgccttt tttaagcagt
     9841 atttgcccgg tgatggcgag gtttggccgt ttggggtcca agagctgctg atggctttga
     9901 cgacggcgat ctgctttctg ttcacttccc gcggcacgca tgagaagaat cgctttggtt
     9961 ttgggccgat catcgaagtc gccgtgttgt ttgcagggat tttcgtgacg atgattccgg
    10021 ccctggcgct gttgaacgtg catggaaagt ccctgggggt tgacgatcca gcggagttct
    10081 tctgggcagc gggaattctt tccagcttcc tggacaatgc tcccacgtat ctgacattcg
    10141 cggcgaccgc gtgcggcatg tatggagtca atacggaaga cgggcggtac ctgcatcact
    10201 tcttgaacct gccagaagcg gcgcagacgg cgcgaatact ggctgcgatc tcgtgcgggg
    10261 cggtcttcat gggggccaat acctatatcg gaaatggtcc caactttatg gtgaaggcga
    10321 ttgccgaaga aaacaacgtc aagatgcccg gcttcttcgg ctatatggcg tactcgatgg
    10381 gaattctgat cccaattttc atcgccgtca cgtttatctt tttccgctag tcgctcgctt
    10441 attgaaggca atcatgcgcg ccatccaact cgaaaaaccg ctgaatttcc gcatcatcga
    10501 tattccggaa cctgacgccc cgctggcggg ggaggccttg gttcgcgtcc accggattgg
    10561 catctgcggg acggatctta gcgggtacct cggcaagatg ccgttctttt cttatccgcg
    10621 gattcccggt catgaactcg gggtggaagt cattgccgtg gggtcagacg tcacgaatgt
    10681 caaagcgggt gatacgtgtt cggttgagcc ctatatgaat aatccgaaca gttttgccag
    10741 ccgacgcggc cggggaaact gttgtgaaga cctgcaggtg ctgggggtgc atactgacgg
    10801 aggcatgcgg ccttatttca agctgccagc gcgcaagctt cataaggcaa ctcagctttc
    10861 gatggaacaa ttggcgcttg tggaaacgct ggcgattggc tgtcactcgg tggcccgctg
    10921 c
//
