GCF_000026185.1_ASM2618v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NC_010694.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	hserlactone	1,054,591	1,075,235	colicin V	RiPP	1%
Region 1.2	thiopeptide	2,408,437	2,434,680	O-antigen	Saccharide	14%
Region 1.3	butyrolactone	2,716,949	2,727,725
Region 1.4	redox-cofactor,NRPS	3,202,570	3,273,088	lankacidin C	NRP + Polyketide	13%
Region 1.5	siderophore	3,378,708	3,391,062	desferrioxamine E	Other	75%

No secondary metabolite regions were found in these records:: NC_010695.1; NC_010696.1; NC_010699.1; NC_010693.1; NC_010697.1

Compact view

NC_010694.1 - Region 1 - hserlactone

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Location: 1,054,591 - 1,075,235 nt. (total: 20,645 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000780.1	0.17	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0000612.1	0.05	RiPP	thiocillin I	Bacillus cereus ATCC 14579
BGC0001555.1	0.04	RiPP	colicin V	Escherichia coli chi7122

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000780.1	0.48	Saccharide	O&K-antigen	Vibrio parahaemolyticus
BGC0000612.1	0.21	RiPP	thiocillin I	Bacillus cereus ATCC 14579
BGC0001555.1	0.20	RiPP	colicin V	Escherichia coli chi7122

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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NC_010694.1 - Region 2 - thiopeptide

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Location: 2,408,437 - 2,434,680 nt. (total: 26,244 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.24	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.07	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000981.1	0.06	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.06	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.05	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.05	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000123.1	0.03	Polyketide	phoslactomycin B	Streptomyces sp. HK803

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.58	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001285.1	0.29	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000981.1	0.24	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E6
BGC0001302.1	0.24	Other	lomofungin	Streptomyces lomondensis
BGC0002012.1	0.23	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0001283.1	0.22	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0000123.1	0.15	Polyketide	phoslactomycin B	Streptomyces sp. HK803

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

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Thiopeptides

Core peptide predictions

No core peptides found.

NC_010694.1 - Region 3 - butyrolactone

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Location: 2,716,949 - 2,727,725 nt. (total: 10,777 nt) Show pHMM detection rules used

butyrolactone: AfsA

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001480.1	0.22	Other	tundrenone	Methylobacter tundripaludum 21/22
BGC0000866.1	0.19	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.1	0.19	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000772.1	0.18	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0000785.1	0.18	Saccharide	O-antigen	Burkholderia mallei
BGC0001120.1	0.17	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001736.1	0.13	NRP	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000914.1	0.09	Other	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000997.1	0.06	NRP, Polyketide	glidobactin	[Polyangium] brachysporum
BGC0001771.1	0.05	NRP	scleric acid	Streptomyces sclerotialus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001480.1	0.55	Other	tundrenone	Methylobacter tundripaludum 21/22
BGC0000866.1	0.52	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.1	0.51	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000772.1	0.50	Saccharide	lipopolysaccharide	Brucella melitensis
BGC0000785.1	0.49	Saccharide	O-antigen	Burkholderia mallei
BGC0001120.1	0.48	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0001736.1	0.41	NRP	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000914.1	0.33	Other	methylenomycin A	Streptomyces coelicolor A3(2)
BGC0000997.1	0.24	NRP, Polyketide	glidobactin	[Polyangium] brachysporum
BGC0001771.1	0.22	NRP	scleric acid	Streptomyces sclerotialus

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NC_010694.1 - Region 4 - NRPS,redox-cofactor

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Location: 3,202,570 - 3,273,088 nt. (total: 70,519 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000309.1	0.34	NRP	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000457.1	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001825.1	0.29	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.1	0.29	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.29	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000368.1	0.28	NRP	streptobactin	Streptomyces sp. ATCC 700974
BGC0001128.1	0.28	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1	0.27	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000359.1	0.27	NRP	fuscachelin A, fuscachelin B, fuscachelin C	Thermobifida fusca YX

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001615.1	0.65	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001444.1	0.64	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.64	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001825.1	0.63	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.1	0.63	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.63	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001185.1	0.62	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001128.1	0.61	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000888.1	0.61	Other	bacilysin	Bacillus sp. CS93

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 3202569 - 3273088:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 3223032 - 3273088:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2929

Search NORINE for peptide: strict or relaxed

AMP-binding (448..848): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAyFgGLVsK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 70% (weak)

AMP-binding (1502..1901): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DlyLmGAVFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

AMP-binding (2548..2950): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DiFNivtIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 60% (weak)

NC_010694.1 - Region 5 - siderophore

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Location: 3,378,708 - 3,391,062 nt. (total: 12,355 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.49	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.30	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.28	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1	0.27	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.1	0.27	Other	desferrioxamine	Streptomyces argillaceus
BGC0001870.1	0.19	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001499.1	0.19	Other	aerobactin	Pantoea ananatis
BGC0001713.1	0.19	Other	ochrobactin	Ochrobactrum anthropi
BGC0000295.1	0.18	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001531.1	0.16	Other	bisucaberin B	Tenacibaculum mesophilum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001572.1	0.78	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.64	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.61	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1	0.60	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.1	0.60	Other	desferrioxamine	Streptomyces argillaceus
BGC0001870.1	0.51	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001499.1	0.51	Other	aerobactin	Pantoea ananatis
BGC0001713.1	0.51	Other	ochrobactin	Ochrobactrum anthropi
BGC0000295.1	0.49	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001531.1	0.47	Other	bisucaberin B	Tenacibaculum mesophilum

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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