LOCUS       c00002_NZ_RBWX..       10834 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_RBWX01000008.1 Sphingosinicella microcystinivorans strain DSM
            19791 Ga0244538_102, whole genome shotgun sequence.
ACCESSION   NZ_RBWX01000008
VERSION     NZ_RBWX01000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:34:30
            Original ID  :: NZ_RBWX01000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 157462
            Orig. end    :: 168296
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10834
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[162462:163296](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5834)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10834
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10834
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(975..2555)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 210.4; E-value: 5.9e-64)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_130"
                     /transl_table=11
                     /translation="MKTIAAVLSVSMTAVPALARPSDSIDAIFARYSGETVPGCAVSAE
                     KDGKTVLERAYGMANIEDRVRAQPGSIYEAGSVSKQFTAAAIVLLARDGKLALSDDIRK
                     YLPEMPDYGTPITIEHLIQHTSGLRDWGSIGAIEGWPRNSRSANNDDVLATAMRQKGLN
                     YAPGTHYSYSNTNFNLAAIIVTRVSGQSFAAFTKARIFDPLGMTSTQWRERYRTLVPGR
                     ATAYAREGDSYVIDQPIEDAHGNGGLLTTVKDLLAWNAALDTDRLGAGFRTAMERTGVL
                     TDGTRIVYASGLRVTKHRGVREVAHSGATGGYRAWLARYPAQHLSIALLCNAGDVDSVA
                     IGQSVAEHYLSDLTPVPVHKPSGKLPEGLYVSEVTGAPITIAARADRTLWVDDTALDPV
                     GPGRWSLSGTDFVFGRDNDLVVEANGEKLRYRRAEPIETVDPAPFVGEYCGDDNPFCMV
                     VRRTTEGGLAIATTGRPGLAAQPLKPVSTDLFTSKYATIRFLRDASGKVSGLTYGDSRA
                     WAVEFTRAP"
     PFAM_domain     complement(1551..2480)
                     /aSDomain="Beta-lactamase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00144.26"
                     /description="Beta-lactamase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_130_0021"
                     /evalue="4.90E-60"
                     /label="ctg2_130"
                     /locus_tag="ctg2_130"
                     /protein_end="335"
                     /protein_start="25"
                     /score="203.6"
                     /tool="antismash"
                     /translation="DAIFARYSGETVPGCAVSAEKDGKTVLERAYGMANIEDRVRAQPG
                     SIYEAGSVSKQFTAAAIVLLARDGKLALSDDIRKYLPEMPDYGTPITIEHLIQHTSGLR
                     DWGSIGAIEGWPRNSRSANNDDVLATAMRQKGLNYAPGTHYSYSNTNFNLAAIIVTRVS
                     GQSFAAFTKARIFDPLGMTSTQWRERYRTLVPGRATAYAREGDSYVIDQPIEDAHGNGG
                     LLTTVKDLLAWNAALDTDRLGAGFRTAMERTGVLTDGTRIVYASGLRVTKHRGVREVAH
                     SGATGGYRAWLARYPAQHLSIALLCNAGD"
     CDS             complement(2552..4078)
                     /locus_tag="ctg2_131"
                     /transl_table=11
                     /translation="MNMGGNKQRLRVLGAILSVVLVGALPASSLVANPAYDVVIRGGRV
                     IDPESGLDAVRNVAIADGRVVAVSAEKLAGRITINADGLVVAPGFIDVHSHGMTIPNGW
                     LQAFDGVTTALELETGAWPVANAYRTAAHEGRPINYGYSVAWSGIRQELMGARAKDLAT
                     DAEIGTILHRVSEGLDAGGLGVGTPVGYSTQTNRTEYWEVASLAAKRGVPVFTHVRTKN
                     GRDPDSALEAFGEVIATAATTGAHMHLCHINSSGLRDIPRLTGMIAKARAYGIPVTSEA
                     YPWGAGSTSIGAPFLAPENLPLLDIGPQNIEVIATGERPATNARLAELRKANPQERIIV
                     HYLNEAIDAERKLIEQALVPEDGIIASDAVRYSVKDRILTEAVWPLPAGVAGHPRSAAT
                     FTKVLGEYVRDRHLLSLADAIRRSTLLPAQLLEPVAPGMKRKGRIGVGMDADIVVFDPA
                     TVGAAATYEKPAEPAKGMRQVLVGGTFVIRDGKLIASARPGQAIRGGTAQ"
     PFAM_domain     complement(2621..3331)
                     /aSDomain="Amidohydro_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07969.13"
                     /description="Amidohydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_131_0023"
                     /evalue="6.10E-12"
                     /label="ctg2_131"
                     /locus_tag="ctg2_131"
                     /protein_end="486"
                     /protein_start="249"
                     /score="45.9"
                     /tool="antismash"
                     /translation="CHINSSGLRDIPRLTGMIAKARAYGIPVTSEAYPWGAGSTSIGAP
                     FLAPENLPLLDIGPQNIEVIATGERPATNARLAELRKANPQERIIVHYLNEAIDAERKL
                     IEQALVPEDGIIASDAVRYSVKDRILTEAVWPLPAGVAGHPRSAATFTKVLGEYVRDRH
                     LLSLADAIRRSTLLPAQLLEPVAPGMKRKGRIGVGMDADIVVFDPATVGAAATYEKPAE
                     PAKGMRQVLVGGTFV"
     PFAM_domain     complement(3305..3847)
                     /aSDomain="Amidohydro_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07969.13"
                     /description="Amidohydrolase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_131_0022"
                     /evalue="1.10E-07"
                     /label="ctg2_131"
                     /locus_tag="ctg2_131"
                     /protein_end="258"
                     /protein_start="77"
                     /score="31.9"
                     /tool="antismash"
                     /translation="TINADGLVVAPGFIDVHSHGMTIPNGWLQAFDGVTTALELETGAW
                     PVANAYRTAAHEGRPINYGYSVAWSGIRQELMGARAKDLATDAEIGTILHRVSEGLDAG
                     GLGVGTPVGYSTQTNRTEYWEVASLAAKRGVPVFTHVRTKNGRDPDSALEAFGEVIATA
                     ATTGAHMHLCHINSSGLR"
     CDS             complement(4213..5004)
                     /locus_tag="ctg2_132"
                     /transl_table=11
                     /translation="VTLIDLQRRFYAAVTGAGEVTFEDWDPAQRAGLAVYRNAYRSRLI
                     ECLRTSFEKTWTWIGDESFDAAAAHHLIVKPPRSWTLDDAGAGFDETLEQLFPNDPEVA
                     ELAWLEWQMQQVFTAADEPVLDAAGFAALSNDFTEEAWTSLRLSFVSGMRSRRIQTDCG
                     AIWAAITAEENLSADVLLNEPRTLLVWRQGIAPRFRLLTAEEAAGFQLMGNGGTFGDMC
                     EAFVQRLGARGIEEAGRTLGFWIAQGIVSRMPAAPAPQPPL"
     PFAM_domain     complement(4729..4989)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_132_0024"
                     /evalue="1.80E-17"
                     /label="ctg2_132"
                     /locus_tag="ctg2_132"
                     /protein_end="92"
                     /protein_start="5"
                     /score="63.4"
                     /tool="antismash"
                     /translation="LQRRFYAAVTGAGEVTFEDWDPAQRAGLAVYRNAYRSRLIECLRT
                     SFEKTWTWIGDESFDAAAAHHLIVKPPRSWTLDDAGAGFDET"
     CDS             complement(5001..5834)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_133"
                     /sec_met_domain="DUF692 (E-value: 1.7e-104, bitscore:
                     344.2, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VTTIQPFNGFGLGLRRDHYADYMAGAVPVDFVEIISENFMVDGGR
                     PLFTLDAIRERYPVAMHGVSMSIGSTEGLDAEYLARLKRLADRVKPLWVSDHLCWTGVN
                     GRNTHDLLPLPYTEEALDVVCRNILHAQDVLERPLLFENPSSYVAFDAGMTEWQFLDAM
                     YERTGCFLLLDVNNIYVSSVNHGFDPIAYLEGIPAATVRQIHLAGHSEGQDILIDTHDT
                     PVCADVWALYQLACARFPSLATMIERDDAIPPIDVLLSELDIARRLSGHDARYAA"
     PFAM_domain     complement(5031..5810)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_133_0025"
                     /evalue="8.00E-106"
                     /label="ctg2_133"
                     /locus_tag="ctg2_133"
                     /protein_end="268"
                     /protein_start="8"
                     /score="353.2"
                     /tool="antismash"
                     /translation="GFGLGLRRDHYADYMAGAVPVDFVEIISENFMVDGGRPLFTLDAI
                     RERYPVAMHGVSMSIGSTEGLDAEYLARLKRLADRVKPLWVSDHLCWTGVNGRNTHDLL
                     PLPYTEEALDVVCRNILHAQDVLERPLLFENPSSYVAFDAGMTEWQFLDAMYERTGCFL
                     LLDVNNIYVSSVNHGFDPIAYLEGIPAATVRQIHLAGHSEGQDILIDTHDTPVCADVWA
                     LYQLACARFPSLATMIERDDAIPPIDVLLSELDIARRL"
     CDS             complement(5911..6195)
                     /locus_tag="ctg2_134"
                     /transl_table=11
                     /translation="MSIALKGAGIASAAALFALSTLASAATAPTGSSGAAVSGADMVHC
                     YGVNSCKGSADCKTTVHECKGHNSCKGQGFKAMKADQCLSKGGTIGDIG"
     CDS             6389..6673
                     /locus_tag="ctg2_135"
                     /transl_table=11
                     /translation="MARETLTPLLATLLAAAVTAGMTNAAQAETKKPAMEKCYGVAKAG
                     QNDCAAGPGTSCAGTSSVDYQGNAWKLVKAGTCLTIKTPKGSGSLTPKA"
     PFAM_domain     6491..6652
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_135_0026"
                     /evalue="8.60E-26"
                     /label="ctg2_135"
                     /locus_tag="ctg2_135"
                     /protein_end="88"
                     /protein_start="34"
                     /score="89.8"
                     /tool="antismash"
                     /translation="MEKCYGVAKAGQNDCAAGPGTSCAGTSSVDYQGNAWKLVKAGTCL
                     TIKTPKGSG"
     CDS             6678..7133
                     /locus_tag="ctg2_136"
                     /transl_table=11
                     /translation="MVALHTGWERVTALLSSRAAEAAPLLLARFALAGVFWRSGRAKIE
                     DGSWFSISDATYYLFREEYTRVPLPSDLAAIAAASAEHIFPVLLVVGLGVRLSALGLLG
                     MTMVIQLFVYPEAWWPVHSLWAALALVLIARGGGVLSLDALFSRRAR"
     PFAM_domain     6750..7019
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_136_0027"
                     /evalue="4.10E-18"
                     /label="ctg2_136"
                     /locus_tag="ctg2_136"
                     /protein_end="114"
                     /protein_start="24"
                     /score="65.9"
                     /tool="antismash"
                     /translation="LLLARFALAGVFWRSGRAKIEDGSWFSISDATYYLFREEYTRVPL
                     PSDLAAIAAASAEHIFPVLLVVGLGVRLSALGLLGMTMVIQLFVY"
     CDS             7130..7657
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 98.6;
                     E-value: 5.4e-30)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_137"
                     /transl_table=11
                     /translation="VKADDASLSRLMALAQRGDRPAYAALLKACSAWLGRYFARRTAPC
                     HLDDLVQETLMSMHGKLASYDPSRPFLPWLAAIARYRWVDHLRRVYRAAEVGLDEDVSV
                     AGGQESVAARLSLDGLLACLPPSQAQVIELVRIEGLSVAEAASRSGQSEALVKVNVHRG
                     LRKLSALIEEAE"
     aSDomain        7202..7633
                     /aSDomain="TIGR02937"
                     /aSTool="tigrfam"
                     /description="sigma70-ECF: RNA polymerase sigma factor,
                     sigma-70 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_137_0002"
                     /evalue="2.50E-18"
                     /identifier="TIGR02937"
                     /label="ctg2_137"
                     /locus_tag="ctg2_137"
                     /protein_end="168"
                     /protein_start="24"
                     /score="64.2"
                     /tool="antismash"
                     /translation="ALLKACSAWLGRYFARRTAPCHLDDLVQETLMSMHGKLASYDPSR
                     PFLPWLAAIARYRWVDHLRRVYRAAEVGLDEDVSVAGGQESVAARLSLDGLLACLPPSQ
                     AQVIELVRIEGLSVAEAASRSGQSEALVKVNVHRGLRKLS"
     PFAM_domain     7235..7396
                     /aSDomain="Sigma70_r2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04542.16"
                     /description="Sigma-70 region 2"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_137_0028"
                     /evalue="2.30E-10"
                     /label="ctg2_137"
                     /locus_tag="ctg2_137"
                     /protein_end="89"
                     /protein_start="35"
                     /score="40.2"
                     /tool="antismash"
                     /translation="RYFARRTAPCHLDDLVQETLMSMHGKLASYDPSRPFLPWLAAIAR
                     YRWVDHLRR"
     PFAM_domain     7472..7630
                     /aSDomain="Sigma70_r4_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08281.14"
                     /description="Sigma-70, region 4"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_137_0029"
                     /evalue="4.40E-12"
                     /label="ctg2_137"
                     /locus_tag="ctg2_137"
                     /protein_end="167"
                     /protein_start="114"
                     /score="45.6"
                     /tool="antismash"
                     /translation="LSLDGLLACLPPSQAQVIELVRIEGLSVAEAASRSGQSEALVKVN
                     VHRGLRKL"
     CDS             7660..8304
                     /locus_tag="ctg2_138"
                     /transl_table=11
                     /translation="MDPDTDTLIASLVDDLRPARVLRRRYGLGLTAAAAAATLAIVAVI
                     FGFRGDISAGHFETLFLIANGLFLILGVACAATVIAMGNPQVGSRHFGWRWVAAATCLL
                     PLSAIIILVSGTEAPPGSLISVHEMDCIFAGVGLGLLTAVVLVFWLRRGAPTSPERAGL
                     LVGVASGCIGIFAFAFHCSSNTIYHVGLWHSAPVIISALLGRVLVPRLVRW"
     PFAM_domain     7693..8301
                     /aSDomain="NrsF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06532.13"
                     /description="Negative regulator of sigma F"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_138_0030"
                     /evalue="6.50E-42"
                     /label="ctg2_138"
                     /locus_tag="ctg2_138"
                     /protein_end="214"
                     /protein_start="11"
                     /score="143.7"
                     /tool="antismash"
                     /translation="LVDDLRPARVLRRRYGLGLTAAAAAATLAIVAVIFGFRGDISAGH
                     FETLFLIANGLFLILGVACAATVIAMGNPQVGSRHFGWRWVAAATCLLPLSAIIILVSG
                     TEAPPGSLISVHEMDCIFAGVGLGLLTAVVLVFWLRRGAPTSPERAGLLVGVASGCIGI
                     FAFAFHCSSNTIYHVGLWHSAPVIISALLGRVLVPRLVRW"
     CDS             8572..9873
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 136.6;
                     E-value: 2e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_139"
                     /transl_table=11
                     /translation="VNSIQTPLGHEPISTSHWSRTAPAAPPCPALEGTIAVDCTIIGAG
                     YSGLIMALELAAAGRSVVVLDAEAPGWAASGRNAGHVAPLFWGAKKTPRQIVAAYGDDM
                     GARMNRMVADSGRWLFDLIDRHGIACDARRGYLYLARTEASLAKHRETFEEWSEFGGVF
                     EAIDCTELARHVTSPNYAGGVWLPNGGLVNPLALSRGLAAAAVREGVQVFGNSRAVSAV
                     KDGEVWRIQTTQGAVRSRTLLVAAGGYADALFPVLRKAAYTVHCGVIATDPLPDKGTST
                     LPGRVPVADLDDKAVFSPAIDAEGCLAISFLIGPGDLEMRKALKICAPRIAKAFPQLSP
                     PEFKRIWAGKFTITPDGAPRLLRLADNAFAATGCNGLGHTLGISAARELAKLALGVGKD
                     AINFRVEDAKPLPASSAANWLLRHVAFPLVNRAG"
     PFAM_domain     8683..9747
                     /aSDomain="DAO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01266.26"
                     /description="FAD dependent oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_139_0031"
                     /evalue="2.20E-47"
                     /label="ctg2_139"
                     /locus_tag="ctg2_139"
                     /protein_end="392"
                     /protein_start="37"
                     /score="162.4"
                     /tool="antismash"
                     /translation="DCTIIGAGYSGLIMALELAAAGRSVVVLDAEAPGWAASGRNAGHV
                     APLFWGAKKTPRQIVAAYGDDMGARMNRMVADSGRWLFDLIDRHGIACDARRGYLYLAR
                     TEASLAKHRETFEEWSEFGGVFEAIDCTELARHVTSPNYAGGVWLPNGGLVNPLALSRG
                     LAAAAVREGVQVFGNSRAVSAVKDGEVWRIQTTQGAVRSRTLLVAAGGYADALFPVLRK
                     AAYTVHCGVIATDPLPDKGTSTLPGRVPVADLDDKAVFSPAIDAEGCLAISFLIGPGDL
                     EMRKALKICAPRIAKAFPQLSPPEFKRIWAGKFTITPDGAPRLLRLADNAFAATGCNGL
                     GHTLGISAARELAKL"
ORIGIN
        1 cgcggccatg cgcgacaaga cgctcgcagc gcttgaagcc atgaaggcgg aaggcgccga
       61 gatcatcgat gtcacgattc cggatttcga gcccacgatg agggcggcga gcgtgattgc
      121 gtatgaattc gcgcgcgact ttgccgccta tcttgcgcgg cacccgggcg caccgatcac
      181 ctcggcctcg gacatcgctg gcaagggcct cgttcacgaa gccgtggatg caagggtaaa
      241 acagcgcagc gcagccgcga cacaagacga aaaggcctac gccgaggctc tggccaaacg
      301 ggccgttgcg cgacgcgtga ttctggatgc gatggcggcg gcgggtgtcg atgcgcttgc
      361 ctatcccaca tccctgcagc cgccgccgct tcggggcgcc gagatgttcg gcgtgggcac
      421 ctgcacgata agcgcagtca ccggtctccc ggctctctcg gttccgctcg ggctcagcat
      481 caatgcgctt cccgttgggc tcgacttgct gggcaagccg tttgaggagg cgaaactgct
      541 gaacctcgcc tatggctggg aacaggctgc ccacccgcgc acgccgccgt tcagcacgcc
      601 tccgcttgcg aatggaaagg caccggcacc atcgcgtttc aaggtgcaaa ctccggcaga
      661 gggaccgcgc gccgatgttg ccttcatcta cgacccgcta aacgccacgc tgcgctatac
      721 cgcccgtcta gatcgtctcg gaagcgacga gcctgtcgcg cttacgctgc aacgcaccga
      781 agacgggaag cccggcgcca tcatcgccaa cctgctgcgg cccggccagc gaaaggcgag
      841 cggtgatctg caactcgaca ctcgcgcccg tgccgacatc gccgccggcc gcctgtacct
      901 caggctctat acgcgcgcgc acccgcttgg ctgggcagaa gcgccgctac aacagcaata
      961 gcagccactc ccgttcatgg tgcgcgcgtg aattccacgg cccacgcacg gctatcacca
     1021 taagtcaggc cgctcacctt tccagacgca tcgcgcagga agcggatggt cgcatacttg
     1081 ctggtgaaga ggtctgtgga caccggcttc aacggctgcg ctgcaaggcc gggccgtccc
     1141 gttgtcgcaa tcgccagccc gccttctgtc gtacggcgaa ccaccatgca gaatggattg
     1201 tcgtcgccgc agtattcgcc aacaaagggt gcgggatcga cggtctcgat cggctccgca
     1261 cgccggtagc gcagcttttc accattggcc tcaaccacga gatcgttgtc ccgcccgaac
     1321 acgaaatccg tgccggacag gctccaacgg ccaggtccga cgggatcgag tgcagtatca
     1381 tcaacccaca aagttctgtc cgcacgcgcg gcaatcgtga tcggtgcgcc agtgacctca
     1441 cttacgtaca ggccttcagg tagcttgccc gagggtttat ggacgggaac gggagtcaag
     1501 tcagagagat aatgttcggc aacgctctgg ccgatcgcga ctgaatcgac atcgccggcg
     1561 ttgcacaaaa gggcaattga gaggtgctgg gccggatagc gcgcgagcca tgcccggtag
     1621 ccacctgtcg ctcccgaatg ggcgacctcc ctgaccccgc gatgcttcgt gacacgcagc
     1681 cccgatgcat agacgatccg cgtgccgtcc gtaagaacgc ccgtgcgctc catcgccgtg
     1741 cggaagcccg ctcccagccg atccgtatcc agcgcggcat tccaggcgag cagatccttc
     1801 accgttgtca gcaggccgcc attgccgtgc gcatcctcta tcggctgatc gattacatag
     1861 gaatcgcctt cgcgcgcata ggccgtggcc cgacccggaa ccagagtccg atagcgttcg
     1921 cgccactgcg tgctcgtcat ccccagagga tcgaagatac gcgccttggt gaacgcggca
     1981 aaactctggc cgctcacgcg ggtcacgatg atcgcggcca gattgaagtt ggtgttggaa
     2041 tagctgtaat gggtgccggg cgcataattc agcccttttt gacgcatagc cgtggccagc
     2101 acatcatcgt tgttggcgct gcgactgttg cgcggccagc cttcgatggc gccgatcgat
     2161 ccccagtccc tgaggccgct cgtgtgctgg atcaggtgct ctatcgtaat cggcgtgcca
     2221 taatcgggca tctccggcag gtatttgcgg atatcatccg aaagcgccag cttgccgtcc
     2281 cgcgccaaca gaacgatcgc cgctgccgtg aactgtttgg agaccgaccc ggcctcgtaa
     2341 atgctgccgg gctgcgcgcg aacgcgatcc tcgatattcg ccataccgta ggcgcgctcc
     2401 agaacggtct tgccgtcctt ctctgcgctg accgcgcatc ccggaacagt ctccccggag
     2461 tagcgtgcga agatcgcatc gatactgtcg ctcggccgcg ccagcgctgg aacggctgtc
     2521 atcgaaaccg aaagcacggc ggctattgtc ttcattgggc tgttcctccg cgaattgcct
     2581 ggccgggacg ggccgacgcg atcagcttgc cgtcccggat aacgaatgtt ccgcccacca
     2641 gaacctggcg cattcccttt gcaggttcag caggcttttc ataggtcgcg gccgcgccca
     2701 ccgtcgcggg gtcaaagaca acgatatccg catccatgcc gacaccgata cgccccttgc
     2761 gtttcatgcc gggcgcaacg ggctccagaa gctgcgctgg gagaagcgtc gaacggcgga
     2821 ttgcatcggc aaggctgagc agatgccggt cacgaacata ttcgccaaga accttcgtga
     2881 acgtcgcggc agaacgggga tgacccgcaa cacccgccgg cagcggccag accgcttcgg
     2941 tcagaatccg atccttcacg gaatagcgga ccgcgtcact tgcgatgatc ccgtcttcgg
     3001 gaacaagcgc ctgctcgatc agctttcgct ccgcatcgat tgcctcgttc agataatgga
     3061 cgatgatccg ttcctgtgga tttgctttgc gcagttccgc aagacgcgcg ttcgttgcgg
     3121 ggcgctcgcc ggtggcgatg acctctatgt tttgcggccc aatatcgagc agaggcagat
     3181 tttcaggtgc aagaaatggg gcgccgatgg acgtcgagcc cgcgccccag gggtaggcct
     3241 cgcttgtcac gggaatgcca taggcgcgcg ccttggcaat catgccggtg agacgcggaa
     3301 tgtcgcgcag gcccgagctg ttgatatggc aaagatgcat gtgcgcgccg gtcgtggcgg
     3361 ccgtggcgat cacttccccg aacgcttcga gcgcactgtc cgggtcgcgc ccgttcttgg
     3421 tgcgaacatg ggtgaatacc ggcacgccgc gctttgccgc aagggacgca acctcccagt
     3481 attcggttct attggtttgg gtggaatagc caaccggcgt cccgacgccg aggccaccgg
     3541 catcgagacc ttcggatacc cgatgcagaa tcgttccgat ttccgcatcc gtcgcaagat
     3601 ccttcgcacg ggcgcccatc agctcctgcc ggattcccga ccatgcaacc gaatacccgt
     3661 aattgatcgg tcgcccctcg tgtgcagcag tacgataagc gttcgcgacc ggccacgcgc
     3721 cggtttcgag ttccagcgcg gtcgtgacac catcgaaggc ttgaagccac ccgttcggaa
     3781 tggtcatgcc gtgcgagtgg acgtcgatga agccaggcgc cacgaccagc ccgtcagcgt
     3841 tgatcgtgat acggcctgca agcttttccg ctgacacggc cacaacacgc ccatcggcaa
     3901 tcgccacgtt ccgaaccgca tcgaggccac tttcgggatc gatgacccgc ccgccgcgga
     3961 taacgacatc gtatgcaggg tttgcaacga gcgacgacgc gggcaacgcg ccgaccagga
     4021 ccaccgaaag gatcgcgccc aagacgcgca gccgctgttt gtttccgccc atgttcatcg
     4081 ctgtcccatt tcccctgccc cggacattcg ccagaacatt ctagagcccg gacagatgct
     4141 ggcttcctca aaatccgcta ttcaccatag ccacgggcta tagccatcgg gccgcgtgcg
     4201 gaagtggcgc gatcagagag gtggctgggg tgcaggagct gcgggcatgc gactgacgat
     4261 cccctgtgcg atccaaaagc cgagtgtacg tccggcctcc tcgatgccgc gagcaccaag
     4321 ccgctggacg aacgcctcgc acatatcgcc gaaagtgccg ccgttcccca tcagctgaaa
     4381 accggcggcc tcctcagccg tcagtagtcg aaaccgtgga gcaattccct gtcgccagac
     4441 aaggagggtc cgcggttcat tcaacagaac atcggctgac aggttctcct cggcggtgat
     4501 tgcggcccag atcgccccgc aatcggtctg tatccgcctt gaacgcattc cgctcacaaa
     4561 tgaaaggcgg agtgaggtcc atgcctcctc cgtgaagtcg ttcgagagcg cggcaaagcc
     4621 tgccgcatcg aggaccggct cgtcagcggc ggtgaagacc tgctgcattt gccattcgag
     4681 ccaggccagc tccgcgacct cggggtcgtt gggaaagagc tgttccagtg tttcatcgaa
     4741 acccgcgccg gcgtcatcga gcgtccagct tcgcggcggc tttacaatga ggtgatgcgc
     4801 cgcggcggca tcgaaactct cgtctccgat ccacgtccac gtcttttcaa aactcgtgcg
     4861 caggcactcg atcagccgcg accgataagc attccggtag accgcaagac ccgctcgctg
     4921 ggccggatcc caatcctcga acgtcacctc cccggcgccc gtcacggcgg cgtagaaacg
     4981 ccgttggaga tcgatcagag tcacgcggcg taccgcgcgt cgtgccctga aagccggcgc
     5041 gcgatatcga gttcgctcag cagcacgtct atcggcggta tcgcatcatc gcgctcgatc
     5101 atggtggcaa gcgaggggaa gcgtgcgcag gcaagctgat agagcgccca cacgtcggcg
     5161 cacaccggcg tgtcgtgcgt gtcgatcagt atgtcctggc cctcgctatg acccgcaaga
     5221 tggatctggc gtaccgtggc ggcgggaatc ccttcgagat acgcgatcgg atcgaatccg
     5281 tgattgacgc tgctgacgta gatattgttg acgtcgagca gcaggaagca gccggtgcgt
     5341 tcgtacatcg catcgagaaa ctgccactcc gtcataccgg cgtcgaaggc gacatagctg
     5401 gacgggtttt cgaacagcag tggacgttca agcacgtcct gcgcatgcag aatgttgcgg
     5461 cacacgacgt ccagcgcctc ttcagtgtag ggcagcggca acaggtcgtg cgtgttgcgg
     5521 ccgttcacgc cagtccagca caggtgatcg gacacccaga ggggcttcac ccggtcggcc
     5581 aaccgtttga ggcgcgcaag atattcagcg tcgaggcctt cggtcgaccc gatcgacatc
     5641 gatacgccgt gcatcgccac cggatagcgc tcgcgaatgg catcgagcgt gaagagcggg
     5701 cggccgccgt ccaccatgaa gttctcggaa atgatctcga cgaaatcgac cggaacggcc
     5761 ccggccatat aatccgcgta gtgatccctg cgaagaccga ggccaaagcc attgaagggt
     5821 tggattgtcg tcacgatggg cgtcctgaaa caaagaggat ggggcgatcc ggtcgcgggg
     5881 ggcgtgcgcc ggatcgcccc ggagggcgcg tcagccgata tcgccgatcg tgccgccctt
     5941 gctcaggcac tggtcggcct tcattgcctt gaagccctgg cccttgcagc tgttgtggcc
     6001 cttgcattcg tgcactgtgg ttttgcagtc agcgctgcct ttgcagctgt tgacaccgta
     6061 gcagtgcacc atgtcggcgc ccgagacggc cgcgccgctg ctgccggtag gcgcggtcgc
     6121 ggcggaggcc agcgttgaaa gagcgaacag ggcggcagcc gatgcgatgc cggccccctt
     6181 cagtgcgatg gacatcagac aaatctccca atgaggtgcg ccggattggc tatcgttcat
     6241 tcgcgcgccc gctccgaaag gttacagtgg cgcccgccaa ttttttattt ttggtcgggt
     6301 gtaacgctcg gcgcgctttg cccgaacttg cagtcagacc gccacatgga aggcggcgct
     6361 gatttcaacc cttatgggag acaagttgat ggcacgcgaa acccttaccc ccctgctcgc
     6421 aaccttgctt gcagcagccg tgacggccgg aatgacgaat gctgcgcagg cggaaacgaa
     6481 gaagcccgcg atggaaaagt gctatggcgt cgcgaaagcc ggccagaacg attgcgccgc
     6541 cggacccggc acgagctgcg caggcacgtc gagcgtcgat tatcagggaa atgcatggaa
     6601 gctggtgaag gcgggaacgt gcctgacgat caagacacca aagggcagcg gctcgctgac
     6661 gcccaaggcg taaacccatg gtcgcgcttc acacaggctg ggagcgggtc acggccctgc
     6721 tctccagccg cgcggcggaa gcggcgccgc tgctgctcgc gcgtttcgcg cttgccggcg
     6781 tattctggcg atccgggcgc gcgaaaattg aagacggaag ctggttttcg atcagcgatg
     6841 cgacctatta tctgtttcgt gaggaatata cccgcgtccc gctgccatcc gatcttgcgg
     6901 ccattgcggc ggcatcggcc gagcatatct ttcccgtgct gctcgttgtc ggcctcggtg
     6961 ttcgcctgtc cgcgctcggg ctgctcggca tgacgatggt gatccagctg ttcgtctacc
     7021 cggaagcttg gtggccggtg cattccctgt gggccgcgct cgcgctcgtc ctcatcgcga
     7081 ggggcggcgg cgtgctgtcg cttgacgcgc ttttcagccg acgcgcgcgg tgaaggcgga
     7141 cgacgccagc ctgtcgcgcc tgatggcgct ggcgcagcgg ggtgatcgcc cggcttacgc
     7201 tgcgctcctg aaggcttgct cggcctggct cggccgctat ttcgcgcggc gcaccgcgcc
     7261 ttgccatctt gacgatctcg tgcaggaaac gctgatgtcg atgcacggca agctggcaag
     7321 ttacgatccc tcgcgtccgt tcctgccctg gcttgcagcg atcgcacgat atcgctgggt
     7381 cgatcatctt cggagggtat atcgcgccgc cgaagtcgga ctcgatgaag acgtgtccgt
     7441 cgccggcggt caggagagtg tcgcggcaag gctcagcctc gacggcctgc tggcctgtct
     7501 gccaccttcc caggcgcagg tgatagagct ggtcaggatc gaggggctct ccgtggcgga
     7561 agccgcttcg cggtcaggcc agagcgaggc gctcgtcaag gtcaatgtac acaggggtct
     7621 caggaaactc agcgccctga tcgaggaagc ggaataacca tggatcctga taccgacacg
     7681 ctcatcgctt cgctggtgga tgacctgcgt ccggcacgcg tcctgcgccg acgctatggg
     7741 ctgggcctga cagcagcagc ggcggccgcc acgctggcca tcgtcgcggt cattttcggg
     7801 ttccggggag acatttccgc agggcacttc gaaaccctgt tcctgatcgc caacggcctg
     7861 ttcctgatcc tgggtgtcgc ctgcgcggca acggtgatcg cgatggggaa tccgcaggtc
     7921 gggagccggc acttcggatg gcgttgggtg gccgcagcca cctgtttgct gcctctgtcc
     7981 gcgatcatca tcctcgtgtc ggggaccgaa gcccctcccg gctcactgat atccgttcac
     8041 gagatggatt gtatctttgc gggtgtcggc ctcgggctgc tcacagccgt agttctggta
     8101 ttctggttgc ggcggggtgc gccgacctca cccgaacgcg cgggacttct cgtgggagtt
     8161 gcgtcggggt gtatcgggat tttcgcgttc gcatttcatt gttcgtcgaa cacgatctat
     8221 catgtcgggc tatggcacag cgcgcccgtt atcatcagcg ccctgctcgg cagggtgttg
     8281 gttccacggc ttgtgcggtg gtgacgcgcg caagatagcc gtccaggcct ccgcgctcgc
     8341 tgaacctggg cgcgcagtac gcacacgatc tttcggacag gttgactgaa aaagcgcgcg
     8401 tcgatttcaa tgcgcagggc tggcagtcct tccaggactt ccagtttccg gcggcgctga
     8461 acgtttatct gctccagaag acctgctcga cggtcgatgc gccaaacggc aagcctgtag
     8521 aggccaaggg agggcgacca tgcagggttc actcgcagac gggttcgcgg cgtgaacagt
     8581 atacaaacgc ccctcggcca cgaacccatc tccacgagcc actggagccg cactgcaccg
     8641 gcagcaccgc cctgccctgc cctcgaaggc acgatagcgg tcgactgcac gatcatcggc
     8701 gcgggctatt ccgggctcat catggcactg gagcttgccg ccgcggggcg cagcgtcgtg
     8761 gttcttgatg ccgaagcccc cggctgggcc gcgtccgggc gcaacgccgg gcatgtcgca
     8821 cctctgttct ggggcgcaaa gaaaacgccg cgtcagatcg ttgccgccta cggcgacgac
     8881 atgggcgcgc gcatgaacag gatggtcgcg gattcggggc ggtggctgtt cgacctgatc
     8941 gacaggcatg gcatcgcgtg cgacgcgcgc cggggctatc tttatttggc ccgaaccgaa
     9001 gcctcactgg cgaaacatcg cgaaaccttt gaagagtgga gcgagttcgg cggtgtcttc
     9061 gaagcaatcg actgcaccga actcgcacgc catgtgacct cgccgaacta tgcgggcggc
     9121 gtgtggctcc cgaacggcgg cctcgtcaat ccgctcgctc tgtctcgcgg ccttgccgcg
     9181 gcagccgtgc gcgaaggggt gcaagtgttc ggaaattcac gcgcggtcag tgccgtgaag
     9241 gacggcgaag tgtggcgcat ccaaaccaca cagggcgccg tgaggagccg aacacttctt
     9301 gtcgccgccg gcggctatgc cgatgcactg tttcccgtac tccgcaaagc cgcctacact
     9361 gtacattgcg gcgtcatcgc caccgatccc ctgcccgaca aggggacgtc gaccctgccg
     9421 ggccgcgttc cggtcgcgga cctggacgac aaggccgtgt tcagccccgc gatcgatgcg
     9481 gaaggatgcc tcgccatcag cttcctgatc gggcccggcg atcttgaaat gcgcaaggcc
     9541 ttgaagatat gcgcgccccg gatcgcaaag gcgtttcctc agttatcccc gccggaattc
     9601 aagcgaatat gggcgggcaa atttacgatc acaccggacg gtgccccgcg acttctgcgc
     9661 cttgccgaca atgcctttgc cgcgaccggc tgcaacggcc tcggccacac cctcggcatt
     9721 tccgctgcgc gcgagctcgc gaaacttgcg ctcggcgtgg gtaaggatgc gataaatttt
     9781 cgggtggagg atgcaaagcc gctaccggcg agcagtgccg ccaactggct gctgagacac
     9841 gttgcgtttc cactcgtcaa ccgggccggc tgacacgcca tatgaacgtc cgtcggcggg
     9901 cggcgcgcag gcataaagtt gacgcaccgc ctgccgaaac gtccggcgac tgatcgtggt
     9961 ccttgttgtt attctccgcg aagttcgcgc ttgatgatct cgatcgtgtc cgggttttcg
    10021 atcgtcggcg gcacggggac gtcctcgccg tttgcaaggc ggcggatcac ggcgcgcagg
    10081 atcttgccgg accgtgtctt gggcagcgcg gcgacgatgt ggacattctt caacgccgcg
    10141 accggaccga gttcctcgcg taccagcgtg atgatctcgt gcgcgagatt gccgtcgtcc
    10201 tgccgtccgg ctttcagaac cgcgaaggcg accggcacca tgccctttac ggcgtcatcg
    10261 gcgccgatga cggcacattc ggccacggca ggatgcgtgg cgatgatctg ttcgatctgc
    10321 ccggtggaaa gccggtgccc ggcgacgttg atcaggtcgt ccgtgcggcc catgatgttg
    10381 acgaaaccgc cttcgtcgat gtgcccggca tcgcccgttt cataatagcc cgcaaaggtt
    10441 tcgaatgcgc gccggaaacc ggtctcgttg ttccacagcg tcgaatagca accgggcggc
    10501 agcggcgcgg cgatcacgac atgacccgta ccgccgggcg ctaccggatc gccgtgatcg
    10561 tcgagcaccg cgaaagtgaa gccgggcacc ggaaaaccgg cgctgcccgc ctgccgccgc
    10621 gtgtcgccta ggccaaggca ggtcgcagca gcgggccagc cgagttcggt ttgccaccag
    10681 tgatcgatca ccggcatcgc aagctgcgtc tccgcccaat gcaccgtatc gggatcggcg
    10741 cgttcaccgg ccaggaacag cgcgcgcagg cggccggtgc cggtttcgcg gatgaagcgg
    10801 ccttcggggt cttccttgcg gatcgcgcgg atcg
//
