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Overview
2.1
2.2
2.3
2.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_UGSZ01000001 (original name was: NZ_UGSZ01000001.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | RRE-containing,lanthipeptide-class-iii | 701,897 | 732,410 |
Region 2.2 | lanthipeptide-class-ii,ranthipeptide | 765,745 | 804,763 |
Region 2.3 | ranthipeptide | 1,030,562 | 1,052,128 |
Region 2.4 | RiPP-like | 1,724,881 | 1,735,669 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | RRE-containing,lanthipeptide-class-iii | 701,897 | 732,410 |
Region 2.2 | lanthipeptide-class-ii,ranthipeptide | 765,745 | 804,763 |
Region 2.3 | ranthipeptide | 1,030,562 | 1,052,128 |
Region 2.4 | RiPP-like | 1,724,881 | 1,735,669 |

No secondary metabolite regions were found in these records:
  NZ_UGSZ01000002 (original name was: NZ_UGSZ01000002.1)

Compact view
c00002_NZ_UGSZ.. - Region 1 - RRE-containing,lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 701,897 - 732,410 nt. (total: 30,514 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000553.1 |  |  | 0.61 | RiPP | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000551.1 |  |  | 0.52 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000496.1 |  |  | 0.50 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.1 |  |  | 0.50 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000518.1 |  |  | 0.47 | RiPP | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000513.1 |  |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001579.1 |  |  | 0.46 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000601.1 |  |  | 0.38 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000780.1 |  |  | 0.36 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000783.1 |  |  | 0.36 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000553.1 |  | 0.66 | RiPP | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000501.1 |  | 0.65 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001579.1 |  | 0.56 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000600.1 |  | 0.55 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000551.1 |  | 0.53 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000496.1 |  | 0.53 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.1 |  | 0.53 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000504.1 |  | 0.53 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000601.1 |  | 0.53 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg2_690 - Putative Class III

ctg2_691 leader / core peptide
  MSNKILKLQEMKANESKVVSR - KDha DhaQDhaNDha CNDhbRDha DhaIDhaIACK

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg2_691 - Class III
  Cleavage pHMM score: -1.30
  RODEO score: 0
  Monoisotopic mass: 1855.9 Da
  Molecular weight: 1857.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1875.1 Da N = 1
    1893.1 Da N = 2
    1911.1 Da N = 3
    1929.1 Da N = 4
    1947.1 Da N = 5
    1965.2 Da N = 6

c00002_NZ_UGSZ.. - Region 2 - lanthipeptide-class-ii,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 765,745 - 804,763 nt. (total: 39,019 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001579.1 |  |  | 0.49 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000528.1 |  |  | 0.42 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000554.1 |  |  | 0.41 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001660.1 |  |  | 0.36 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000496.1 |  |  | 0.35 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000551.1 |  |  | 0.35 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000501.1 |  |  | 0.35 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001289.1 |  |  | 0.35 | RiPP | penisin | Paenibacillus ehimensis
BGC0000539.1 |  |  | 0.33 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001787.1 |  |  | 0.33 | RiPP | suicin 3908 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.1 |  | 0.66 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000528.1 |  | 0.65 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000554.1 |  | 0.59 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.1 |  | 0.56 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0001660.1 |  | 0.56 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0001787.1 |  | 0.55 | RiPP | suicin 3908 | Streptococcus suis
BGC0000599.1 |  | 0.53 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000539.1 |  | 0.53 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000496.1 |  | 0.53 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000551.1 |  | 0.52 | RiPP | SapB | Streptomyces coelicolor A3(2)

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lanthipeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
c00002_NZ_UGSZ.. - Region 3 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,030,562 - 1,052,128 nt. (total: 21,567 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001887.1 |  | 0.13 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001887.1 |  | 0.42 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_UGSZ.. - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,724,881 - 1,735,669 nt. (total: 10,789 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000487.1 |  | 0.16 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000554.1 |  | 0.15 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001743.1 |  | 0.15 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001579.1 |  | 0.15 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000486.1 |  | 0.15 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000548.1 |  | 0.14 | RiPP | salivaricin A | Streptococcus salivarius
BGC0001120.1 |  | 0.14 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000759.1 |  | 0.14 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159
BGC0000768.1 |  | 0.14 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000797.1 |  | 0.14 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000487.1 |  | 0.47 | RiPP | carnocyclin | Carnobacterium maltaromaticum
BGC0000554.1 |  | 0.46 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001743.1 |  | 0.45 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001579.1 |  | 0.45 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000486.1 |  | 0.45 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000548.1 |  | 0.44 | RiPP | salivaricin A | Streptococcus salivarius
BGC0001120.1 |  | 0.44 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000759.1 |  | 0.43 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159
BGC0000768.1 |  | 0.43 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000797.1 |  | 0.43 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names