Select genomic region:
Overview
18.1
19.1
25.1
30.1
34.1
45.1
49.1
53.1
56.1
56.2
67.1

### Identified secondary metabolite regions using strictness 'relaxed'

c00018_NZ_JAWO.. (original name was: NZ_JAWONS010000096.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | cyclic-lactone-autoinducer | 1 | 16,795 |

c00019_NZ_JAWO.. (original name was: NZ_JAWONS010000099.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 19.1 | NRPS,cyclic-lactone-autoinducer | 1 | 51,106 |

c00025_NZ_JAWO.. (original name was: NZ_JAWONS010000123.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 25.1 | cyclic-lactone-autoinducer | 60,626 | 80,173 |

c00030_NZ_JAWO.. (original name was: NZ_JAWONS010000133.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 30.1 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 37,279 | 67,555 |

c00034_NZ_JAWO.. (original name was: NZ_JAWONS010000167.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 34.1 | resorcinol,cyclic-lactone-autoinducer | 36,680 | 75,260 | yersiniabactin | NRP + Polyketide | 5%

c00045_NZ_JAWO.. (original name was: NZ_JAWONS010000240.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 45.1 | cyclic-lactone-autoinducer | 86,905 | 107,656 |

c00049_NZ_JAWO.. (original name was: NZ_JAWONS010000252.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 49.1 | cyclic-lactone-autoinducer | 58,210 | 81,673 |

c00053_NZ_JAWO.. (original name was: NZ_JAWONS010000280.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 53.1 | ranthipeptide | 20,229 | 41,623 |

c00056_NZ_JAWO.. (original name was: NZ_JAWONS010000290.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 56.1 | RRE-containing | 60,297 | 80,587 |
Region 56.2 | RiPP-like | 148,843 | 161,002 |

c00067_NZ_JAWO.. (original name was: NZ_JAWONS010000329.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 67.1 | transAT-PKS,PKS-like,cyclic-lactone-autoinducer | 75,331 | 170,593 | kalimantacin A | NRP + Polyketide:Modular type I + Polyketide:Trans-AT type I | 10%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | cyclic-lactone-autoinducer | 1 | 16,795 |
Region 19.1 | NRPS,cyclic-lactone-autoinducer | 1 | 51,106 |
Region 25.1 | cyclic-lactone-autoinducer | 60,626 | 80,173 |
Region 30.1 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 37,279 | 67,555 |
Region 34.1 | resorcinol,cyclic-lactone-autoinducer | 36,680 | 75,260 | yersiniabactin | NRP + Polyketide | 5%
Region 45.1 | cyclic-lactone-autoinducer | 86,905 | 107,656 |
Region 49.1 | cyclic-lactone-autoinducer | 58,210 | 81,673 |
Region 53.1 | ranthipeptide | 20,229 | 41,623 |
Region 56.1 | RRE-containing | 60,297 | 80,587 |
Region 56.2 | RiPP-like | 148,843 | 161,002 |
Region 67.1 | transAT-PKS,PKS-like,cyclic-lactone-autoinducer | 75,331 | 170,593 | kalimantacin A | NRP + Polyketide:Modular type I + Polyketide:Trans-AT type I | 10%

No secondary metabolite regions were found in these records:
  c00001_NZ_JAWO.. (original name was: NZ_JAWONS010000002.1)
  c00002_NZ_JAWO.. (original name was: NZ_JAWONS010000011.1)
  c00003_NZ_JAWO.. (original name was: NZ_JAWONS010000012.1)
  c00004_NZ_JAWO.. (original name was: NZ_JAWONS010000021.1)
  c00005_NZ_JAWO.. (original name was: NZ_JAWONS010000026.1)
  c00006_NZ_JAWO.. (original name was: NZ_JAWONS010000030.1)
  c00007_NZ_JAWO.. (original name was: NZ_JAWONS010000037.1)
  c00008_NZ_JAWO.. (original name was: NZ_JAWONS010000044.1)
  c00009_NZ_JAWO.. (original name was: NZ_JAWONS010000045.1)
  c00010_NZ_JAWO.. (original name was: NZ_JAWONS010000049.1)
  c00011_NZ_JAWO.. (original name was: NZ_JAWONS010000058.1)
  c00012_NZ_JAWO.. (original name was: NZ_JAWONS010000064.1)
  c00013_NZ_JAWO.. (original name was: NZ_JAWONS010000068.1)
  c00014_NZ_JAWO.. (original name was: NZ_JAWONS010000079.1)
  c00015_NZ_JAWO.. (original name was: NZ_JAWONS010000089.1)
  c00016_NZ_JAWO.. (original name was: NZ_JAWONS010000090.1)
  c00017_NZ_JAWO.. (original name was: NZ_JAWONS010000091.1)
  c00020_NZ_JAWO.. (original name was: NZ_JAWONS010000102.1)
  c00021_NZ_JAWO.. (original name was: NZ_JAWONS010000103.1)
  c00022_NZ_JAWO.. (original name was: NZ_JAWONS010000107.1)
  c00023_NZ_JAWO.. (original name was: NZ_JAWONS010000109.1)
  c00024_NZ_JAWO.. (original name was: NZ_JAWONS010000121.1)
  c00026_NZ_JAWO.. (original name was: NZ_JAWONS010000124.1)
  c00027_NZ_JAWO.. (original name was: NZ_JAWONS010000126.1)
  c00028_NZ_JAWO.. (original name was: NZ_JAWONS010000130.1)
  c00029_NZ_JAWO.. (original name was: NZ_JAWONS010000131.1)
  c00031_NZ_JAWO.. (original name was: NZ_JAWONS010000138.1)
  c00032_NZ_JAWO.. (original name was: NZ_JAWONS010000148.1)
  c00033_NZ_JAWO.. (original name was: NZ_JAWONS010000165.1)
  c00035_NZ_JAWO.. (original name was: NZ_JAWONS010000177.1)
  c00036_NZ_JAWO.. (original name was: NZ_JAWONS010000179.1)
  c00037_NZ_JAWO.. (original name was: NZ_JAWONS010000184.1)
  c00038_NZ_JAWO.. (original name was: NZ_JAWONS010000186.1)
  c00039_NZ_JAWO.. (original name was: NZ_JAWONS010000206.1)
  c00040_NZ_JAWO.. (original name was: NZ_JAWONS010000216.1)
  c00041_NZ_JAWO.. (original name was: NZ_JAWONS010000218.1)
  c00042_NZ_JAWO.. (original name was: NZ_JAWONS010000221.1)
  c00043_NZ_JAWO.. (original name was: NZ_JAWONS010000222.1)
  c00044_NZ_JAWO.. (original name was: NZ_JAWONS010000238.1)
  c00046_NZ_JAWO.. (original name was: NZ_JAWONS010000244.1)
  c00047_NZ_JAWO.. (original name was: NZ_JAWONS010000245.1)
  c00048_NZ_JAWO.. (original name was: NZ_JAWONS010000248.1)
  c00050_NZ_JAWO.. (original name was: NZ_JAWONS010000275.1)
  c00051_NZ_JAWO.. (original name was: NZ_JAWONS010000278.1)
  c00052_NZ_JAWO.. (original name was: NZ_JAWONS010000279.1)
  c00054_NZ_JAWO.. (original name was: NZ_JAWONS010000285.1)
  c00055_NZ_JAWO.. (original name was: NZ_JAWONS010000286.1)
  c00057_NZ_JAWO.. (original name was: NZ_JAWONS010000291.1)
  c00058_NZ_JAWO.. (original name was: NZ_JAWONS010000292.1)
  c00059_NZ_JAWO.. (original name was: NZ_JAWONS010000306.1)
  c00060_NZ_JAWO.. (original name was: NZ_JAWONS010000309.1)
  c00061_NZ_JAWO.. (original name was: NZ_JAWONS010000316.1)
  c00062_NZ_JAWO.. (original name was: NZ_JAWONS010000317.1)
  c00063_NZ_JAWO.. (original name was: NZ_JAWONS010000319.1)
  c00064_NZ_JAWO.. (original name was: NZ_JAWONS010000320.1)
  c00065_NZ_JAWO.. (original name was: NZ_JAWONS010000324.1)
  c00066_NZ_JAWO.. (original name was: NZ_JAWONS010000326.1)
  c00068_NZ_JAWO.. (original name was: NZ_JAWONS010000331.1)

Compact view
c00018_NZ_JAWO.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,795 nt. (total: 16,795 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.1 |  | 0.18 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.1 |  | 0.18 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000249.1 |  | 0.16 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0001925.1 |  | 0.15 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0000774.1 |  | 0.14 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001098.1 |  | 0.10 | NRP, Polyketide | iturin | Bacillus subtilis
BGC0001090.1 |  | 0.09 | NRP, Polyketide | bacillomycin D | Bacillus velezensis FZB42
BGC0000864.1 |  | 0.06 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001941.1 |  | 0.05 | NRP, Polyketide | fulvuthiacene A, fulvuthiacene B | Myxococcus fulvus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.1 |  | 0.50 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.1 |  | 0.50 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0001120.1 |  | 0.47 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000249.1 |  | 0.47 | Polyketide | nogalamycin | Streptomyces nogalater
BGC0001925.1 |  | 0.44 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001098.1 |  | 0.35 | NRP, Polyketide | iturin | Bacillus subtilis
BGC0001090.1 |  | 0.34 | NRP, Polyketide | bacillomycin D | Bacillus velezensis FZB42
BGC0000864.1 |  | 0.25 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001941.1 |  | 0.22 | NRP, Polyketide | fulvuthiacene A, fulvuthiacene B | Myxococcus fulvus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00019_NZ_JAWO.. - Region 1 - NRPS,cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 51,106 nt. (total: 51,106 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000426.1 |  |  | 0.31 | NRP | sevadicin | Paenibacillus larvae
BGC0001399.1 |  |  | 0.31 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001767.1 |  |  | 0.30 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001686.1 |  |  | 0.30 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000349.1 |  |  | 0.30 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001833.1 |  |  | 0.29 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000396.1 |  |  | 0.29 | NRP | nodularin | Nostoc sp. 73.1
BGC0000389.1 |  |  | 0.29 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001135.1 |  |  | 0.28 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001479.1 |  |  | 0.28 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.1 |  | 0.64 | NRP | sevadicin | Paenibacillus larvae
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001767.1 |  | 0.64 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001686.1 |  | 0.64 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000349.1 |  | 0.63 | NRP | erythrochelin | Saccharopolyspora erythraea NRRL 2338
BGC0001833.1 |  | 0.63 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000396.1 |  | 0.63 | NRP | nodularin | Nostoc sp. 73.1
BGC0000389.1 |  | 0.63 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001135.1 |  | 0.62 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001479.1 |  | 0.62 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 51106:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X - X) + (X - glu - glu - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg19_8: X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (472..862): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWlVgAViK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1981..2371): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWlVgAViK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
ctg19_10: X - glu - glu - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (472..862): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAwLIGAViK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (1504..1907): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDvGVVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (2549..2952): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDvGVVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (3594..3982): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWLIGAIiK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      90% (moderate)

c00025_NZ_JAWO.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 60,626 - 80,173 nt. (total: 19,548 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000294.1 |  | 0.16 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000540.1 |  | 0.10 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000472.1 |  | 0.09 | RiPP | anacyclamide A10 | Anabaena sp. 90
BGC0000565.1 |  | 0.06 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000624.1 |  | 0.05 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001653.1 |  | 0.05 | Polyketide | linfuranone B, linfuranone C | Microbispora sp. GMKU363
BGC0000203.1 |  | 0.03 | Polyketide | BE-7585A | Amycolatopsis orientalis subsp. vinearia

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000294.1 |  | 0.46 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000540.1 |  | 0.37 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000472.1 |  | 0.33 | RiPP | anacyclamide A10 | Anabaena sp. 90
BGC0000565.1 |  | 0.27 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000624.1 |  | 0.23 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001653.1 |  | 0.22 | Polyketide | linfuranone B, linfuranone C | Microbispora sp. GMKU363
BGC0000203.1 |  | 0.17 | Polyketide | BE-7585A | Amycolatopsis orientalis subsp. vinearia

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
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c00030_NZ_JAWO.. - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 37,279 - 67,555 nt. (total: 30,277 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000528.1 |  |  | 0.70 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.1 |  |  | 0.69 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000503.1 |  |  | 0.63 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000539.1 |  |  | 0.62 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000547.1 |  |  | 0.60 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0001787.1 |  |  | 0.59 | RiPP | suicin 3908 | Streptococcus suis
BGC0000498.1 |  |  | 0.54 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000561.1 |  |  | 0.54 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000500.1 |  |  | 0.53 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000525.1 |  |  | 0.52 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.1 |  | 0.68 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001579.1 |  | 0.68 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000503.1 |  | 0.66 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0000539.1 |  | 0.64 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000547.1 |  | 0.63 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0001787.1 |  | 0.63 | RiPP | suicin 3908 | Streptococcus suis
BGC0000498.1 |  | 0.61 | RiPP | bovicin HJ50 | Streptococcus equinus
BGC0000561.1 |  | 0.61 | RiPP | thermophilin 1277 | Streptococcus thermophilus
BGC0000500.1 |  | 0.60 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000557.1 |  | 0.60 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg30_51 - Putative Class II

ctg30_50 leader / core peptide
  MNNMRNAVKRINFINPVGNVMKEMEEAELNRVSAG - AGVLRMDhaGGVVC DhbADhbAECYYGDhbYLKRC CPK

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg30_50 - Class II
  Cleavage pHMM score: -2.80
  RODEO score: 0
  Monoisotopic mass: 3081.5 Da
  Molecular weight: 3083.7 Da
  Number of bridges: 3
  Additional modifications: AviCys

c00034_NZ_JAWO.. - Region 1 - cyclic-lactone-autoinducer,resorcinol
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 36,680 - 75,260 nt. (total: 38,581 nt) Show pHMM detection rules used
Region on contig edge.
resorcinol: DarB
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | resorcinol | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001810.1 |  |  | 0.30 | Polyketide | trehangelin | Polymorphospora rubra
BGC0001150.1 |  |  | 0.29 | Polyketide | pamamycin-607 | Streptomyces alboniger
BGC0000813.1 |  |  | 0.27 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000898.1 |  |  | 0.27 | Saccharide | desosamine | Streptomyces venezuelae
BGC0000025.1 |  |  | 0.27 | Polyketide | avermectin | Streptomyces avermitilis
BGC0000794.1 |  |  | 0.27 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000773.1 |  |  | 0.27 | Saccharide | lipopolysaccharide | Escherichia coli
BGC0000790.1 |  |  | 0.27 | Saccharide | O-antigen | Escherichia coli
BGC0000795.1 |  |  | 0.27 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000791.1 |  |  | 0.27 | Saccharide | O-antigen | Cronobacter sakazakii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000813.1 |  | 0.61 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000245.1 |  | 0.60 | Polyketide | medermycin | Streptomyces sp. AM-7161
BGC0000825.1 |  | 0.59 | Alkaloid | staurosporine | Streptomyces sp. TP-A0274
BGC0000880.1 |  | 0.57 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0001960.1 |  | 0.56 | Polyketide | hiroshidine | Streptomyces hiroshimensis
BGC0000261.1 |  | 0.55 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0001730.1 |  | 0.55 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.
BGC0000272.1 |  | 0.54 | Polyketide | spore pigment | Streptomyces collinus
BGC0000253.1 |  | 0.53 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0001513.1 |  | 0.53 | Polyketide | anthrabenzoxocinone | Actinobacteria bacterium

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00045_NZ_JAWO.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 86,905 - 107,656 nt. (total: 20,752 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.20 | RiPP | circularin A | Clostridium beijerinckii
BGC0000896.1 |  | 0.17 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000496.1 |  | 0.17 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000542.1 |  | 0.16 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000551.1 |  | 0.16 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000517.1 |  | 0.16 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000774.1 |  | 0.16 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0000552.1 |  | 0.16 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0001391.1 |  | 0.16 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.52 | RiPP | circularin A | Clostridium beijerinckii
BGC0000896.1 |  | 0.48 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000496.1 |  | 0.48 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000542.1 |  | 0.47 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000551.1 |  | 0.47 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000517.1 |  | 0.47 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000519.1 |  | 0.46 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000774.1 |  | 0.46 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0000552.1 |  | 0.46 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0001391.1 |  | 0.46 | RiPP | thusin | Bacillus thuringiensis serovar rongseni

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00049_NZ_JAWO.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 58,210 - 81,673 nt. (total: 23,464 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001323.1 |  | 0.15 | Terpene | monoterpenes-diterpenes | Solanum pennellii
BGC0001235.1 |  | 0.14 | NRP, Polyketide | antalid | Polyangium spumosum
BGC0001484.1 |  | 0.13 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0001321.1 |  | 0.12 | Terpene | monoterpenes-diterpenes | Solanum habrochaites
BGC0001324.1 |  | 0.09 | Terpene | monoterpenes-diterpenes | Solanum pimpinellifolium
BGC0001322.1 |  | 0.09 | Terpene | lycosantalonol | Solanum lycopersicum
BGC0001078.1 |  | 0.08 | Terpene, Polyketide | furaquinocin B | Streptomyces sp. KO-3988
BGC0001406.1 |  | 0.06 | NRP | telomycin | Streptomyces canus
BGC0000291.1 |  | 0.05 | NRP | A54145 | Streptomyces fradiae
BGC0000974.1 |  | 0.05 | NRP, Polyketide | crocacin | Chondromyces crocatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001323.1 |  | 0.45 | Terpene | monoterpenes-diterpenes | Solanum pennellii
BGC0001235.1 |  | 0.43 | NRP, Polyketide | antalid | Polyangium spumosum
BGC0001484.1 |  | 0.42 | Other | 2'-chloropentostatin, 2'-amino-2'-deoxyadenosine | Actinomadura sp. ATCC 39365
BGC0001321.1 |  | 0.39 | Terpene | monoterpenes-diterpenes | Solanum habrochaites
BGC0001324.1 |  | 0.34 | Terpene | monoterpenes-diterpenes | Solanum pimpinellifolium
BGC0001322.1 |  | 0.34 | Terpene | lycosantalonol | Solanum lycopersicum
BGC0001078.1 |  | 0.30 | Terpene, Polyketide | furaquinocin B | Streptomyces sp. KO-3988
BGC0001406.1 |  | 0.26 | NRP | telomycin | Streptomyces canus
BGC0000291.1 |  | 0.23 | NRP | A54145 | Streptomyces fradiae
BGC0000974.1 |  | 0.21 | NRP, Polyketide | crocacin | Chondromyces crocatus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00053_NZ_JAWO.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 20,229 - 41,623 nt. (total: 21,395 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000780.1 |  | 0.17 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000231.1 |  | 0.17 | Polyketide | griseusin | Streptomyces griseus
BGC0000888.1 |  | 0.17 | Other | bacilysin | Bacillus sp. CS93
BGC0000797.1 |  | 0.16 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88
BGC0000886.1 |  | 0.16 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000794.1 |  | 0.16 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001894.1 |  | 0.16 | Saccharide | heteropolysaccharide (HePS) | Lactobacillus plantarum
BGC0000768.1 |  | 0.16 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000730.1 |  | 0.16 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000731.1 |  | 0.16 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000780.1 |  | 0.48 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000231.1 |  | 0.48 | Polyketide | griseusin | Streptomyces griseus
BGC0000888.1 |  | 0.48 | Other | bacilysin | Bacillus sp. CS93
BGC0000797.1 |  | 0.47 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88
BGC0000886.1 |  | 0.47 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0000794.1 |  | 0.47 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001894.1 |  | 0.47 | Saccharide | heteropolysaccharide (HePS) | Lactobacillus plantarum
BGC0000768.1 |  | 0.46 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000730.1 |  | 0.46 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000731.1 |  | 0.46 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00056_NZ_JAWO.. - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 60,297 - 80,587 nt. (total: 20,291 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000904.1 |  | 0.21 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001859.1 |  | 0.20 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000386.1 |  | 0.13 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0000486.1 |  | 0.09 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001277.1 |  | 0.08 | Terpene | nivalenol, vomitoxin, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-deacetylcalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene | Fusarium graminearum
BGC0001278.1 |  | 0.07 | Terpene | nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-decalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene | Fusarium sporotrichioides
BGC0001687.1 |  | 0.06 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001053.1 |  | 0.04 | NRP, Polyketide | tubulysin A | Archangium disciforme
BGC0001979.1 |  | 0.04 | Polyketide | LL-D49194α1 (LLD) | Streptomyces vinaceusdrappus
BGC0000974.1 |  | 0.04 | NRP, Polyketide | crocacin | Chondromyces crocatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000904.1 |  | 0.54 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001859.1 |  | 0.53 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000386.1 |  | 0.42 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0000486.1 |  | 0.33 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001277.1 |  | 0.30 | Terpene | nivalenol, vomitoxin, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-deacetylcalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene | Fusarium graminearum
BGC0001278.1 |  | 0.28 | Terpene | nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, neosolaniol, calonectrin, apotrichodiol, isotrichotriol, 15-decalonectrin, T-2 toxin, 3-acetyl T-2 toxin, trichodiene | Fusarium sporotrichioides
BGC0001687.1 |  | 0.26 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSL12
BGC0001053.1 |  | 0.20 | NRP, Polyketide | tubulysin A | Archangium disciforme
BGC0001979.1 |  | 0.18 | Polyketide | LL-D49194α1 (LLD) | Streptomyces vinaceusdrappus
BGC0000974.1 |  | 0.17 | NRP, Polyketide | crocacin | Chondromyces crocatus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00056_NZ_JAWO.. - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 148,843 - 161,002 nt. (total: 12,160 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.23 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001862.1 |  | 0.21 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.21 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.21 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.20 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000617.1 |  | 0.18 | RiPP | coagulin | Bacillus coagulans
BGC0000516.1 |  | 0.18 | RiPP | geobacillin II | Geobacillus thermodenitrificans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.56 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001862.1 |  | 0.54 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.54 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.53 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.53 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000617.1 |  | 0.50 | RiPP | coagulin | Bacillus coagulans
BGC0000516.1 |  | 0.49 | RiPP | geobacillin II | Geobacillus thermodenitrificans

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00067_NZ_JAWO.. - Region 1 - PKS-like,cyclic-lactone-autoinducer,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 75,331 - 170,593 nt. (total: 95,263 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
PKS-like: (t2pks2 or ksIII)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | PKS-like | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000205.1 |  |  |  | 0.73 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000234.1 |  |  |  | 0.73 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000253.1 |  |  |  | 0.60 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000261.1 |  |  |  | 0.55 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0001730.1 |  |  |  | 0.53 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.
BGC0001258.1 |  |  |  | 0.50 | Polyketide | 1,3,6,8-tetrahydroxynaphthalene | Glarea lozoyensis
BGC0000223.1 |  |  |  | 0.48 | Polyketide | rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H | uncultured bacterium BAC AB649/1850
BGC0000979.1 |  |  |  | 0.48 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  |  | 0.48 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000043.1 |  |  |  | 0.47 | Polyketide | curacin A | Moorea producens 19L

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000174.1 |  | 0.60 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0000234.1 |  | 0.60 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000205.1 |  | 0.59 | Polyketide | bryostatin | Candidatus Endobugula sertula
BGC0002008.1 |  | 0.58 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001163.1 |  | 0.58 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0000180.1 |  | 0.58 | Polyketide | legioliulin | Legionella parisiensis
BGC0000263.1 |  | 0.57 | Polyketide | ravidomycin | Streptomyces ravidus
BGC0000836.1 |  | 0.57 | Other | APE Ec | Escherichia coli CFT073
BGC0000223.1 |  | 0.57 | Polyketide | rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H | uncultured bacterium BAC AB649/1850
BGC0000258.1 |  | 0.56 | Polyketide | prodigiosin | Serratia sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 75330 - 170593:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (mal - ccmal - ohmal - ohmal) + (mal - mal - ohmal - mal) + (ccmal - ccmal - ohmal - mal) + (ccmal - mal - mal)
Non-colinear ordering:
  ctg67_90 + ctg67_91 + ctg67_92 + ctg67_89 + ctg67_103 + ctg67_100 + ctg67_101

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg67_93: pk
  CAL_domain (165..468): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 90.0
    NH2: 14.8
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
ctg67_101: mal
  PKS_AT (4..280): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 75.0%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 93.7
    inactive: 38.8
    Methoxymalonyl-CoA: 22.8
    Methylmalonyl-CoA: 17.7
    Propionyl-CoA: 15.2
    fatty_acid: 9.0
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg67_103: pk
  PKS_AT (7..290): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: inactive
  Prediction, score:
    inactive: 18.4
    Malonyl-CoA: 9.7
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0