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Overview
1.1
2.1
3.1
3.2
4.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB946332.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 754,561 | 777,674 |

NZ_KB946333.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii | 124,014 | 146,914 |

NZ_KB946334.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | ranthipeptide | 170,799 | 192,240 |
Region 3.2 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 259,811 | 285,005 | cytolysin ClyLl / cytolysin ClyLs | RiPP:Lanthipeptide | 40%

NZ_KB946335.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | LAP | 642,470 | 665,576 | listeriolysin S | RiPP:LAP | 75%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 754,561 | 777,674 |
Region 2.1 | lanthipeptide-class-ii | 124,014 | 146,914 |
Region 3.1 | ranthipeptide | 170,799 | 192,240 |
Region 3.2 | cyclic-lactone-autoinducer,lanthipeptide-class-ii | 259,811 | 285,005 | cytolysin ClyLl / cytolysin ClyLs | RiPP:Lanthipeptide | 40%
Region 4.1 | LAP | 642,470 | 665,576 | listeriolysin S | RiPP:LAP | 75%

Compact view
NZ_KB946332.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 754,561 - 777,674 nt. (total: 23,114 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.32 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.1 |  | 0.29 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.25 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.1 |  | 0.24 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000528.1 |  | 0.23 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000516.1 |  | 0.20 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000517.1 |  | 0.20 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000527.1 |  | 0.20 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001229.1 |  | 0.19 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001311.1 |  | 0.17 | RiPP | flavecins | Ruminococcus flavefaciens FD-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.65 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.1 |  | 0.63 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.1 |  | 0.58 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.1 |  | 0.57 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000528.1 |  | 0.56 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000516.1 |  | 0.53 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000517.1 |  | 0.52 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000527.1 |  | 0.52 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001229.1 |  | 0.50 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001311.1 |  | 0.49 | RiPP | flavecins | Ruminococcus flavefaciens FD-1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lanthipeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
NZ_KB946333.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 124,014 - 146,914 nt. (total: 22,901 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.18 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000502.1 |  | 0.15 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001210.1 |  | 0.15 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001407.1 |  | 0.13 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000548.1 |  | 0.13 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000877.1 |  | 0.06 | Other | polyoxin A, polyoxin H | Streptomyces cacaoi subsp. asoensis
BGC0001057.1 |  | 0.05 | NRP, Polyketide | zearalenone | Fusarium graminearum
BGC0001056.1 |  | 0.04 | NRP, Polyketide | zeamine, zeamine I, zeamine II, prezeamine, prezeamine I | Serratia plymuthica RVH1
BGC0001281.1 |  | 0.04 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000806.1 |  | 0.04 | Saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.49 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000502.1 |  | 0.45 | RiPP | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001210.1 |  | 0.45 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001407.1 |  | 0.41 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0000548.1 |  | 0.41 | RiPP | salivaricin A | Streptococcus salivarius
BGC0000877.1 |  | 0.25 | Other | polyoxin A, polyoxin H | Streptomyces cacaoi subsp. asoensis
BGC0001057.1 |  | 0.23 | NRP, Polyketide | zearalenone | Fusarium graminearum
BGC0001056.1 |  | 0.21 | NRP, Polyketide | zeamine, zeamine I, zeamine II, prezeamine, prezeamine I | Serratia plymuthica RVH1
BGC0001281.1 |  | 0.19 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000806.1 |  | 0.19 | Saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg2_114 - Putative Class II

ctg2_115 leader / core peptide
  MRKLSIEKMETAKDLKKVDSVVGA - DhaFERDhaKNDhaEEDhbVDRDhaEDhbIVANDhbIGGWDhaRIICLP
allorf_0131151_0131318 leader / core peptide
  MFICDEPLARKQLVLRCVLQQFQLISERITSAAIVYS - DhbHFFNKYLDhbVGLPHDhaLC C

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg2_115 - Class II
  Cleavage pHMM score: -2.80
  RODEO score: 0
  Monoisotopic mass: 3549.8 Da
  Molecular weight: 3551.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3569.9 Da N = 1
    3587.9 Da N = 2
    3606.0 Da N = 3
    3624.0 Da N = 4
    3642.0 Da N = 5
    3660.0 Da N = 6
    3678.0 Da N = 7
allorf_0131151_0131318 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2025.0 Da
  Molecular weight: 2026.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2044.4 Da N = 1

NZ_KB946334.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 170,799 - 192,240 nt. (total: 21,442 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001929.1 |  | 0.30 | RiPP | WGK | Streptococcus ferus
BGC0001364.1 |  | 0.16 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001510.1 |  | 0.15 | Other | anisomycin | Streptomyces hygrospinosus
BGC0000469.1 |  | 0.12 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0000691.1 |  | 0.11 | Saccharide | acarbose | Actinoplanes sp. SE50/110
BGC0000804.1 |  | 0.11 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0001728.1 |  | 0.08 | NRP, Polyketide | paenilipoheptin | Paenibacillus polymyxa E681
BGC0001812.1 |  | 0.07 | Polyketide | tylactone | Micromonospora chalcea subsp. izumensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001929.1 |  | 0.63 | RiPP | WGK | Streptococcus ferus
BGC0001364.1 |  | 0.46 | RiPP | cinnamycin B | Actinomadura atramentaria DSM 43919
BGC0001510.1 |  | 0.45 | Other | anisomycin | Streptomyces hygrospinosus
BGC0000469.1 |  | 0.40 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0000691.1 |  | 0.38 | Saccharide | acarbose | Actinoplanes sp. SE50/110
BGC0000804.1 |  | 0.38 | Saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0001728.1 |  | 0.30 | NRP, Polyketide | paenilipoheptin | Paenibacillus polymyxa E681
BGC0001812.1 |  | 0.29 | Polyketide | tylactone | Micromonospora chalcea subsp. izumensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB946334.1 - Region 2 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 259,811 - 285,005 nt. (total: 25,195 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lanthipeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000504.1 |  |  | 0.84 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.1 |  |  | 0.63 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.1 |  |  | 0.54 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000525.1 |  |  | 0.50 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000540.1 |  |  | 0.46 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000528.1 |  |  | 0.46 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001229.1 |  |  | 0.45 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000558.1 |  |  | 0.45 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000539.1 |  |  | 0.45 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001291.1 |  |  | 0.45 | RiPP | enterocin NKR-5-3B | Enterococcus faecium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.1 |  | 0.73 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.1 |  | 0.65 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000500.1 |  | 0.61 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000525.1 |  | 0.59 | RiPP | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000540.1 |  | 0.56 | RiPP | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0000528.1 |  | 0.56 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001229.1 |  | 0.56 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000558.1 |  | 0.56 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000539.1 |  | 0.56 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0001291.1 |  | 0.55 | RiPP | enterocin NKR-5-3B | Enterococcus faecium

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.

#### Lanthipeptide(s) for ctg3_243 - Putative Class II

ctg3_246 leader / core peptide
  VEKIVGKAFEELTEEEMKKMQGS - GDVQPEDhb DhbPICGFDhbIGIGIGALADhaVKWC
ctg3_247 leader / core peptide
  MEKIIGQSFEELSKKEMEAMQGS - GDVQAEDhb DhbPVCAIDhaADhbVAADha DhaAACAGVGAGIGDhbGIDhbIVLDhbFKRC
ctg3_248 leader / core peptide
  MEKIIGQSFEELSKKEMEAMQGS - GDVQVEDhb DhbPVCAIDhaADhbVAADha DhaAACAGVGAGIGDhbGIDhbIVLDhbFKRC
ctg3_249 leader / core peptide
  MEKIIGQSFEELSKKEMEAMQGS - GDVQAEDhb DhbPVCAIDhaADhbVAADha DhaAACAGVGAGIGDhbGIDhbIVLDhbFKRC
ctg3_250 leader / core peptide
  MEEIVGKAFEELTEEEMKNMQGS - GDVQPEDhb DhbPLCGFDhbIGIGIGALVDhaVKWC
allorf_270990_271106 leader / core peptide
  VLPFFSITLEGYLERSTENGE - DRCAHDhbANFC CHEFKKN

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg3_246 - Class II
  Cleavage pHMM score: -0.30
  RODEO score: 0
  Monoisotopic mass: 2760.4 Da
  Molecular weight: 2762.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2780.2 Da N = 1
    2798.2 Da N = 2
ctg3_247 - Class II
  Cleavage pHMM score: 1.60
  RODEO score: 0
  Monoisotopic mass: 3975.1 Da
  Molecular weight: 3977.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3995.6 Da N = 1
    4013.6 Da N = 2
    4031.6 Da N = 3
    4049.6 Da N = 4
    4067.6 Da N = 5
    4085.7 Da N = 6
ctg3_248 - Class II
  Cleavage pHMM score: 1.60
  RODEO score: 0
  Monoisotopic mass: 4003.1 Da
  Molecular weight: 4005.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4023.6 Da N = 1
    4041.6 Da N = 2
    4059.7 Da N = 3
    4077.7 Da N = 4
    4095.7 Da N = 5
    4113.7 Da N = 6
ctg3_249 - Class II
  Cleavage pHMM score: 1.60
  RODEO score: 0
  Monoisotopic mass: 3975.1 Da
  Molecular weight: 3977.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3995.6 Da N = 1
    4013.6 Da N = 2
    4031.6 Da N = 3
    4049.6 Da N = 4
    4067.6 Da N = 5
    4085.7 Da N = 6
ctg3_250 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 2788.5 Da
  Molecular weight: 2790.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2808.3 Da N = 1
    2826.3 Da N = 2
allorf_270990_271106 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 2004.9 Da
  Molecular weight: 2006.2 Da
  Number of bridges: 1

NZ_KB946335.1 - Region 1 - LAP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
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Location: 642,470 - 665,576 nt. (total: 23,107 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001171.1 |  | 0.41 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000568.1 |  | 0.26 | RiPP | microcin B17 | Escherichia coli
BGC0000566.1 |  | 0.23 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0002013.1 |  | 0.23 | RiPP | curacozole | Streptomyces curacoi
BGC0000565.1 |  | 0.19 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000564.1 |  | 0.18 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.1 |  | 0.18 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000626.1 |  | 0.16 | RiPP | thuricin | Bacillus thuringiensis
BGC0001356.1 |  | 0.16 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001645.1 |  | 0.16 | RiPP | lagmysin | Streptomyces sp. NRRL S-118

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001171.1 |  | 0.73 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000568.1 |  | 0.60 | RiPP | microcin B17 | Escherichia coli
BGC0000566.1 |  | 0.56 | RiPP | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0002013.1 |  | 0.56 | RiPP | curacozole | Streptomyces curacoi
BGC0000565.1 |  | 0.51 | RiPP | goadsporin | Streptomyces sp. TP-A0584
BGC0000564.1 |  | 0.49 | RiPP | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.1 |  | 0.49 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000626.1 |  | 0.47 | RiPP | thuricin | Bacillus thuringiensis
BGC0001356.1 |  | 0.47 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001645.1 |  | 0.47 | RiPP | lagmysin | Streptomyces sp. NRRL S-118

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
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