GCF_018394375.1_ASM1839437v1_genomic - 9 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP074578.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	arylpolyene	370,486	414,085	aryl polyenes	Other	38%
Region 1.2	NRPS	1,812,636	1,871,150	rimosamide	NRP	14%
Region 1.3	hserlactone	1,971,633	1,992,292
Region 1.4	NRPS	2,003,502	2,093,319	pyoverdin	NRP	22%
Region 1.5	NRPS,siderophore	2,747,502	2,828,205	syringafactin	NRP	66%
Region 1.6	NAGGN	4,107,810	4,122,609
Region 1.7	NAPAA,redox-cofactor	5,092,117	5,137,466	lankacidin C	NRP + Polyketide	13%
Region 1.8	NRPS-like	5,505,011	5,547,395	fragin	NRP	37%
Region 1.9	NRPS	5,657,418	5,711,640

No secondary metabolite regions were found in these records:: NZ_CP074579.1

Compact view

NZ_CP074578.1 - Region 1 - arylpolyene

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Location: 370,486 - 414,085 nt. (total: 43,600 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.28	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.27	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001444.1	0.26	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.26	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001723.1	0.24	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234.1	0.23	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.22	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001897.1	0.22	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000194.1	0.22	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000272.1	0.21	Polyketide	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000836.1	0.62	Other	APE Ec	Escherichia coli CFT073
BGC0002008.1	0.60	Other	aryl polyenes	Xenorhabdus doucetiae
BGC0001444.1	0.59	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.59	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001723.1	0.58	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234.1	0.56	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000228.1	0.55	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001897.1	0.55	Polyketide	cepacin A	Burkholderia ambifaria IOP40-10
BGC0000194.1	0.55	Polyketide	actinorhodin	Streptomyces coelicolor A3(2)
BGC0000272.1	0.54	Polyketide	spore pigment	Streptomyces collinus

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP074578.1 - Region 2 - NRPS

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Location: 1,812,636 - 1,871,150 nt. (total: 58,515 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.38	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.38	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000426.1	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0001561.1	0.36	NRP	curacomycin	Streptomyces curacoi
BGC0000427.1	0.36	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.35	NRP	indigoidine	Streptomyces chromofuscus
BGC0001185.1	0.35	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000417.1	0.34	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000465.1	0.34	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001615.1	0.33	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.71	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001050.1	0.70	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000426.1	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001561.1	0.69	NRP	curacomycin	Streptomyces curacoi
BGC0000427.1	0.69	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000375.1	0.68	NRP	indigoidine	Streptomyces chromofuscus
BGC0001185.1	0.68	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000417.1	0.67	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000465.1	0.67	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001615.1	0.67	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 1812635 - 1871150:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (arg - pro - cys) + (X) + (X - pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1614

Search NORINE for peptide: strict or relaxed

AMP-binding (30..441): arg

NRPSPredictor2: arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: arg
Single AA prediction:: arg

Stachelhaus prediction details:

Stachelhaus sequence:: DVADVGAIDK
Nearest Stachelhaus code:: arg
Stachelhaus code match:: 100% (strong)

AMP-binding (1104..1514): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAqVVK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 90% (moderate)

AMP-binding (2168..2572): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNmSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg1_1615

Search NORINE for peptide: strict or relaxed

AMP-binding (534..941): X

NRPSPredictor2: phe, trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: phe, trp
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWvFGvViK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 70% (weak)

ctg1_1616

Search NORINE for peptide: strict or relaxed

AMP-binding (19..418): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGaTFK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 90% (moderate)

AMP-binding (1063..1470): pro

NRPSPredictor2: pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: pro
Single AA prediction:: pro

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 100% (strong)

NZ_CP074578.1 - Region 3 - hserlactone

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Location: 1,971,633 - 1,992,292 nt. (total: 20,660 nt) Show pHMM detection rules used

hserlactone: Autoind_synth

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.1	0.28	Other	ectoine	Streptomyces anulatus
BGC0000859.1	0.28	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.28	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.1	0.28	Other	ectoine	Methylomicrobium kenyense
BGC0000857.1	0.28	Other	ectoine	Methylophaga alcalica
BGC0000852.1	0.28	Other	ectoine	Sporosarcina pasteurii
BGC0000856.1	0.28	Other	ectoine	Methylophaga thalassica
BGC0000860.1	0.27	Other	ectoine	Methylarcula marina
BGC0000858.1	0.27	Other	ectoine	Methylobacter marinus
BGC0001687.1	0.19	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.1	0.62	Other	ectoine	Streptomyces anulatus
BGC0000859.1	0.62	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.62	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.1	0.62	Other	ectoine	Methylomicrobium kenyense
BGC0000857.1	0.61	Other	ectoine	Methylophaga alcalica
BGC0000852.1	0.61	Other	ectoine	Sporosarcina pasteurii
BGC0000856.1	0.61	Other	ectoine	Methylophaga thalassica
BGC0000860.1	0.61	Other	ectoine	Methylarcula marina
BGC0000858.1	0.60	Other	ectoine	Methylobacter marinus
BGC0001687.1	0.51	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_CP074578.1 - Region 4 - NRPS

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Location: 2,003,502 - 2,093,319 nt. (total: 89,818 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.49	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001758.1	0.37	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.36	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001615.1	0.36	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001131.1	0.35	NRP	ambactin	Xenorhabdus miraniensis
BGC0001833.1	0.35	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417.1	0.34	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000426.1	0.34	NRP	sevadicin	Paenibacillus larvae
BGC0001135.1	0.33	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001434.1	0.33	NRP	nematophin	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.78	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001758.1	0.70	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.69	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001615.1	0.69	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001131.1	0.68	NRP	ambactin	Xenorhabdus miraniensis
BGC0001833.1	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417.1	0.67	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000426.1	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0001135.1	0.66	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001434.1	0.66	NRP	nematophin	Xenorhabdus budapestensis

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 2003501 - 2093319:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (glu - D-X - X) + (X) + (D-asn - thr) + (thr - ser) + (D-asn - ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1790

Search NORINE for peptide: strict or relaxed

CAL_domain (40..481): pk

minowa: NH2

Prediction, score:

NH2: 158.8
Acetyl-CoA: 45.4
AHBA: 16.0
fatty_acid: 15.9
shikimic_acid: 1.3

AMP-binding (1139..1537): glu

NRPSPredictor2: glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: glu, gln
Single AA prediction:: glu

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFGRINK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 100% (strong)

AMP-binding (2196..2600): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAegiGAVMK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 70% (weak)

AMP-binding (3729..4135): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiWeLtadDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 50% (weak)

ctg1_1802

Search NORINE for peptide: strict or relaxed

AMP-binding (521..930): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGedhGtVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 60% (weak)

ctg1_1803

Search NORINE for peptide: strict or relaxed

AMP-binding (506..923): asn

NRPSPredictor2: asn

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGhVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 90% (moderate)

AMP-binding (2015..2416): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

ctg1_1804

Search NORINE for peptide: strict or relaxed

AMP-binding (504..905): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1556..1956): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg1_1805

Search NORINE for peptide: strict or relaxed

AMP-binding (505..897): asn

NRPSPredictor2: asn

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asp

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGhVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 90% (moderate)

AMP-binding (1999..2399): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

NZ_CP074578.1 - Region 5 - NRPS,siderophore

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Location: 2,747,502 - 2,828,205 nt. (total: 80,704 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.50	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000855.1	0.49	Other	ectoine	Methylomicrobium kenyense
BGC0001767.1	0.41	NRP	salinichelins	Salinispora pacifica CNY331
BGC0001211.1	0.39	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0000368.1	0.37	NRP	streptobactin	Streptomyces sp. ATCC 700974
BGC0001758.1	0.37	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001498.1	0.37	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001131.1	0.37	NRP	ambactin	Xenorhabdus miraniensis
BGC0000426.1	0.36	NRP	sevadicin	Paenibacillus larvae
BGC0001844.1	0.36	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.79	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001758.1	0.70	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001498.1	0.69	Other	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001131.1	0.69	NRP	ambactin	Xenorhabdus miraniensis
BGC0000426.1	0.69	NRP	sevadicin	Paenibacillus larvae
BGC0001844.1	0.68	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001128.1	0.68	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.1	0.67	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000942.1	0.67	Other	petrobactin	Bacillus anthracis str. Ames
BGC0000401.1	0.67	NRP	paenibactin	Paenibacillus elgii B69

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 5, location 2747501 - 2828205:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu - leu - X) + (leu - thr - ile - leu - leu)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 2747501 - 2812350:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu - leu - X) + (leu - thr - ile - leu - leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2402

Search NORINE for peptide: strict or relaxed

AMP-binding (471..860): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (1535..1922): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (2587..2986): X

NRPSPredictor2: asp, asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAwqvGVVDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)

ctg1_2403

Search NORINE for peptide: strict or relaxed

AMP-binding (550..943): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (1599..2002): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (2672..3067): ile

NRPSPredictor2: ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFLGaTfK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 80% (moderate)

AMP-binding (3723..4111): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

AMP-binding (4782..5170): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGNVVK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 100% (strong)

NZ_CP074578.1 - Region 6 - NAGGN

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Location: 4,107,810 - 4,122,609 nt. (total: 14,800 nt) Show pHMM detection rules used

NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000846.1	0.18	Other	tabtoxin	Pseudomonas syringae
BGC0000888.1	0.16	Other	bacilysin	Bacillus sp. CS93
BGC0000885.1	0.15	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000265.1	0.15	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0001928.1	0.14	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000231.1	0.14	Polyketide	griseusin	Streptomyces griseus
BGC0001156.1	0.14	Terpene	platencin	Streptomyces platensis
BGC0000207.1	0.14	Polyketide	chartreusin	Streptomyces chartreusis
BGC0000937.1	0.14	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0001140.1	0.14	Terpene	platensimycin, platencin	Streptomyces platensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000846.1	0.50	Other	tabtoxin	Pseudomonas syringae
BGC0000888.1	0.47	Other	bacilysin	Bacillus sp. CS93
BGC0000885.1	0.45	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000265.1	0.44	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0001928.1	0.44	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000231.1	0.43	Polyketide	griseusin	Streptomyces griseus
BGC0001156.1	0.43	Terpene	platencin	Streptomyces platensis
BGC0000207.1	0.43	Polyketide	chartreusin	Streptomyces chartreusis
BGC0000937.1	0.43	Other	fosfazinomycin A	Streptomyces sp. WM6372
BGC0001140.1	0.43	Terpene	platensimycin, platencin	Streptomyces platensis

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_CP074578.1 - Region 7 - NAPAA,redox-cofactor

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Location: 5,092,117 - 5,137,466 nt. (total: 45,350 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and PP-binding and TIGR02353)
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000703.1	0.28	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001607.1	0.26	Other	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000813.1	0.21	Alkaloid	K-252a	Nonomuraea longicatena
BGC0001479.1	0.19	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001132.1	0.18	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000375.1	0.18	NRP	indigoidine	Streptomyces chromofuscus
BGC0001900.1	0.18	NRP	fragin	Burkholderia cenocepacia H111
BGC0001833.1	0.18	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.1	0.18	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.1	0.60	Other	showdomycin	Streptomyces showdoensis
BGC0000258.1	0.59	Polyketide	prodigiosin	Serratia sp.
BGC0000259.1	0.58	Polyketide	prodigiosin	Serratia marcescens
BGC0000890.1	0.56	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0001465.1	0.55	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0000891.1	0.55	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16
BGC0000260.1	0.54	Polyketide	prodigiosin	Hahella chejuensis KCTC 2396
BGC0000427.1	0.54	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001444.1	0.54	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001441.1	0.53	Other	belactosin A, belactosin C	Streptomyces sp.

Similar known gene clusters

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Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 9, location 5092116 - 5137466:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 5092116 - 5126157:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_4464

Search NORINE for peptide: strict or relaxed

AMP-binding (37..434): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DmEHNgTVSK
Nearest Stachelhaus code:: dab
Stachelhaus code match:: 80% (moderate)

NZ_CP074578.1 - Region 8 - NRPS-like

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Location: 5,505,011 - 5,547,395 nt. (total: 42,385 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001900.1	0.35	NRP	fragin	Burkholderia cenocepacia H111
BGC0001168.1	0.32	NRP	livipeptin	Streptomyces lividans 1326
BGC0001599.1	0.26	NRP	fragin	Burkholderia cenocepacia H111
BGC0001778.1	0.25	Other	showdomycin	Streptomyces showdoensis
BGC0001516.1	0.25	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0000427.1	0.21	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001465.1	0.18	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0000890.1	0.18	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0001758.1	0.18	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000891.1	0.18	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001900.1	0.68	NRP	fragin	Burkholderia cenocepacia H111
BGC0001168.1	0.66	NRP	livipeptin	Streptomyces lividans 1326
BGC0001599.1	0.60	NRP	fragin	Burkholderia cenocepacia H111
BGC0001778.1	0.59	Other	showdomycin	Streptomyces showdoensis
BGC0001516.1	0.58	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0000427.1	0.54	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001465.1	0.50	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0000890.1	0.50	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas phenolica O-BC30
BGC0001758.1	0.50	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000891.1	0.50	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 12, location 5505010 - 5547395:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_4819

Search NORINE for peptide: strict or relaxed

AMP-binding (199..583): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DsiFmGLVlK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 60% (weak)

NZ_CP074578.1 - Region 9 - NRPS

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Location: 5,657,418 - 5,711,640 nt. (total: 54,223 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001399.1	0.31	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000457.1	0.30	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001826.1	0.30	NRP	xeneprotides A-C	Xenorhabdus sp. KJ12.1
BGC0001261.1	0.27	NRP	AM-toxin	Alternaria alternata
BGC0001132.1	0.27	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.27	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000342.1	0.26	NRP	enniatin	Fusarium equiseti
BGC0000313.1	0.26	NRP	beauvericin	Beauveria bassiana
BGC0001825.1	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001050.1	0.26	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000457.1	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001826.1	0.63	NRP	xeneprotides A-C	Xenorhabdus sp. KJ12.1
BGC0001261.1	0.61	NRP	AM-toxin	Alternaria alternata
BGC0001132.1	0.61	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.1	0.60	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000342.1	0.60	NRP	enniatin	Fusarium equiseti
BGC0000313.1	0.60	NRP	beauvericin	Beauveria bassiana
BGC0001825.1	0.60	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001050.1	0.59	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 13, location 5657417 - 5711640:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser - beta-ala) + (NMe-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_4943

Search NORINE for peptide: strict or relaxed

AMP-binding (540..935): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLIDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

AMP-binding (1588..1983): beta-ala

NRPSPredictor2: beta-ala

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VDAthSLADK
Nearest Stachelhaus code:: beta-ala
Stachelhaus code match:: 80% (moderate)

ctg1_4946

Search NORINE for peptide: strict or relaxed

AMP-binding (443..836): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFqIGaiFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)