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Overview
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1.9

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_AP024722.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | ectoine,NRPS-like | 239,593 | 291,620 | ectoine | Other | 83%
Region 2 | arylpolyene | 638,397 | 681,996 | APE Vf | Other | 45%
Region 3 | NAGGN | 1,350,196 | 1,365,176 |
Region 4 | lassopeptide | 1,885,424 | 1,907,402 |
Region 5 | redox-cofactor | 2,315,700 | 2,344,051 | lankacidin C | NRP + Polyketide | 13%
Region 6 | betalactone | 2,744,425 | 2,771,483 |
Region 7 | betalactone | 3,537,658 | 3,567,672 | fengycin | NRP | 13%
Region 8 | siderophore | 3,956,270 | 3,968,078 | desferrioxamine E | Other | 100%
Region 9 | terpene | 4,123,479 | 4,147,082 | carotenoid | Terpene | 100%

NZ_AP024722.1 - Region 1 - NRPS-like,ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 239,593 - 291,620 nt. (total: 52,028 nt) Show pHMM detection rules used
ectoine: ectoine_synt
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000853.1 |  |  | 0.52 | Other | ectoine | Streptomyces anulatus
BGC0000856.1 |  |  | 0.48 | Other | ectoine | Methylophaga thalassica
BGC0000859.1 |  |  | 0.48 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000855.1 |  |  | 0.43 | Other | ectoine | Methylomicrobium kenyense
BGC0000858.1 |  |  | 0.40 | Other | ectoine | Methylobacter marinus
BGC0000852.1 |  |  | 0.39 | Other | ectoine | Sporosarcina pasteurii
BGC0000854.1 |  |  | 0.37 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000857.1 |  |  | 0.35 | Other | ectoine | Methylophaga alcalica
BGC0000860.1 |  |  | 0.29 | Other | ectoine | Methylarcula marina
BGC0001444.1 |  |  | 0.23 | Other | caboxamycin | Streptomyces sp. NTK 937

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000853.1 |  | 0.80 | Other | ectoine | Streptomyces anulatus
BGC0000856.1 |  | 0.77 | Other | ectoine | Methylophaga thalassica
BGC0000859.1 |  | 0.77 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000855.1 |  | 0.74 | Other | ectoine | Methylomicrobium kenyense
BGC0000854.1 |  | 0.74 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000857.1 |  | 0.73 | Other | ectoine | Methylophaga alcalica
BGC0000858.1 |  | 0.72 | Other | ectoine | Methylobacter marinus
BGC0000852.1 |  | 0.71 | Other | ectoine | Sporosarcina pasteurii
BGC0000860.1 |  | 0.67 | Other | ectoine | Methylarcula marina
BGC0000234.1 |  | 0.58 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 239592 - 291620:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 248884 - 291620:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_247: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (36..432): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      shvsSGhqiK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      30% (weak)

NZ_AP024722.1 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 638,397 - 681,996 nt. (total: 43,600 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000836.1 |  | 0.28 | Other | APE Ec | Escherichia coli CFT073
BGC0002008.1 |  | 0.28 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001723.1 |  | 0.24 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0001366.1 |  | 0.24 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0000889.1 |  | 0.24 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000234.1 |  | 0.23 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.22 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0002029.1 |  | 0.22 | Other | bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C | Streptomyces lunaelactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000836.1 |  | 0.61 | Other | APE Ec | Escherichia coli CFT073
BGC0002008.1 |  | 0.61 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001723.1 |  | 0.58 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.57 | Polyketide | griseusin | Streptomyces griseus
BGC0001366.1 |  | 0.57 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0000889.1 |  | 0.57 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000234.1 |  | 0.56 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.55 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)
BGC0002029.1 |  | 0.55 | Other | bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C | Streptomyces lunaelactis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_AP024722.1 - Region 3 - NAGGN
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,350,196 - 1,365,176 nt. (total: 14,981 nt) Show pHMM detection rules used
NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAGGN | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.22 | Other | tabtoxin | Pseudomonas syringae
BGC0000885.1 |  | 0.21 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000937.1 |  | 0.17 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000854.1 |  | 0.17 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000857.1 |  | 0.16 | Other | ectoine | Methylophaga alcalica
BGC0001739.1 |  | 0.13 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001374.1 |  | 0.13 | Other | thienodolin | Streptomyces albogriseolus
BGC0000375.1 |  | 0.11 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000796.1 |  | 0.10 | Saccharide | S-layer glycan | Paenibacillus alvei
BGC0001395.1 |  | 0.10 | Other | teichomycin | Actinoplanes teichomyceticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.54 | Other | tabtoxin | Pseudomonas syringae
BGC0000885.1 |  | 0.54 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000937.1 |  | 0.48 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000854.1 |  | 0.48 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000857.1 |  | 0.47 | Other | ectoine | Methylophaga alcalica
BGC0001739.1 |  | 0.42 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001374.1 |  | 0.42 | Other | thienodolin | Streptomyces albogriseolus
BGC0000375.1 |  | 0.38 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000796.1 |  | 0.35 | Saccharide | S-layer glycan | Paenibacillus alvei
BGC0001395.1 |  | 0.35 | Other | teichomycin | Actinoplanes teichomyceticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_AP024722.1 - Region 4 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,885,424 - 1,907,402 nt. (total: 21,979 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Lasso peptides
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000577.1 |  | 0.23 | RiPP | sphingonodin II | Sphingobium japonicum UT26S
BGC0001639.1 |  | 0.22 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0001634.1 |  | 0.20 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.19 | RiPP | lariatin | Rhodococcus jostii
BGC0001176.1 |  | 0.19 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001551.1 |  | 0.19 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001549.1 |  | 0.19 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001550.1 |  | 0.19 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.19 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001889.1 |  | 0.19 | RiPP | fusilassin | Thermobifida fusca YX

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000577.1 |  | 0.56 | RiPP | sphingonodin II | Sphingobium japonicum UT26S
BGC0001639.1 |  | 0.55 | RiPP | klebsidin | Klebsiella pneumoniae
BGC0001634.1 |  | 0.53 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.1 |  | 0.51 | RiPP | lariatin | Rhodococcus jostii
BGC0001176.1 |  | 0.51 | RiPP | streptomonomicin | Streptomonospora alba
BGC0001551.1 |  | 0.51 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001549.1 |  | 0.51 | RiPP | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0001550.1 |  | 0.51 | RiPP | citrulassin D | Streptomyces katrae
BGC0001552.1 |  | 0.51 | RiPP | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001889.1 |  | 0.50 | RiPP | fusilassin | Thermobifida fusca YX

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash.
Lassopeptides - No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
NZ_AP024722.1 - Region 5 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,315,700 - 2,344,051 nt. (total: 28,352 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001441.1 |  | 0.15 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000703.1 |  | 0.15 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001925.1 |  | 0.14 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0000883.1 |  | 0.13 | Other | arginomycin | Streptomyces arginensis
BGC0000906.1 |  | 0.13 | Other | heme D1 | Heliophilum fasciatum
BGC0001241.1 |  | 0.13 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.13 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0000897.1 |  | 0.12 | Other | dehydrophos | Streptomyces luridus
BGC0000811.1 |  | 0.12 | Alkaloid | fumigaclavine C | Aspergillus fumigatus Af293

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001441.1 |  | 0.45 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0000703.1 |  | 0.45 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001925.1 |  | 0.44 | Alkaloid | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0000883.1 |  | 0.42 | Other | arginomycin | Streptomyces arginensis
BGC0000906.1 |  | 0.41 | Other | heme D1 | Heliophilum fasciatum
BGC0001241.1 |  | 0.41 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.41 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0000897.1 |  | 0.40 | Other | dehydrophos | Streptomyces luridus
BGC0000811.1 |  | 0.39 | Alkaloid | fumigaclavine C | Aspergillus fumigatus Af293

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_AP024722.1 - Region 6 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,744,425 - 2,771,483 nt. (total: 27,059 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001286.1 |  | 0.21 | Other | itaconic acid | Ustilago maydis
BGC0000258.1 |  | 0.19 | Polyketide | prodigiosin | Serratia sp.
BGC0000259.1 |  | 0.19 | Polyketide | prodigiosin | Serratia marcescens
BGC0000867.1 |  | 0.17 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000260.1 |  | 0.16 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0000866.1 |  | 0.16 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000274.1 |  | 0.16 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0000386.1 |  | 0.16 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001706.1 |  | 0.14 | Terpene | nodulisporic acid F | Hypoxylon pulicicidum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001286.1 |  | 0.54 | Other | itaconic acid | Ustilago maydis
BGC0000258.1 |  | 0.52 | Polyketide | prodigiosin | Serratia sp.
BGC0000259.1 |  | 0.51 | Polyketide | prodigiosin | Serratia marcescens
BGC0000867.1 |  | 0.48 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000260.1 |  | 0.47 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0000866.1 |  | 0.47 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000274.1 |  | 0.46 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0000386.1 |  | 0.46 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0001120.1 |  | 0.46 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001706.1 |  | 0.43 | Terpene | nodulisporic acid F | Hypoxylon pulicicidum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_AP024722.1 - Region 7 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
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Location: 3,537,658 - 3,567,672 nt. (total: 30,015 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.29 | Other | showdomycin | Streptomyces showdoensis
BGC0000866.1 |  | 0.24 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.1 |  | 0.23 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000649.1 |  | 0.20 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000234.1 |  | 0.20 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000891.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000890.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0001465.1 |  | 0.20 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0001588.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.63 | Other | showdomycin | Streptomyces showdoensis
BGC0000866.1 |  | 0.57 | Other | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.1 |  | 0.56 | Other | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000649.1 |  | 0.53 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000234.1 |  | 0.53 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001897.1 |  | 0.53 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000891.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000890.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0001465.1 |  | 0.52 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0001588.1 |  | 0.47 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_AP024722.1 - Region 8 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,956,270 - 3,968,078 nt. (total: 11,809 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001478.1 |  | 0.47 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.40 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.1 |  | 0.37 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000940.1 |  | 0.35 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.1 |  | 0.35 | Other | desferrioxamine | Streptomyces argillaceus
BGC0001361.1 |  | 0.29 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0001531.1 |  | 0.22 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001499.1 |  | 0.21 | Other | aerobactin | Pantoea ananatis
BGC0001713.1 |  | 0.19 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000295.1 |  | 0.18 | NRP | acinetoferrin | Acinetobacter haemolyticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001478.1 |  | 0.77 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  | 0.72 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.1 |  | 0.70 | Other | desferrioxamine E | Pantoea agglomerans
BGC0000940.1 |  | 0.68 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.1 |  | 0.68 | Other | desferrioxamine | Streptomyces argillaceus
BGC0001361.1 |  | 0.63 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0001531.1 |  | 0.55 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001499.1 |  | 0.53 | Other | aerobactin | Pantoea ananatis
BGC0001713.1 |  | 0.51 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000295.1 |  | 0.50 | NRP | acinetoferrin | Acinetobacter haemolyticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_AP024722.1 - Region 9 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,123,479 - 4,147,082 nt. (total: 23,604 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000656.1 |  | 0.55 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000647.1 |  | 0.48 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000642.1 |  | 0.47 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000641.1 |  | 0.46 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000638.1 |  | 0.46 | Terpene | carotenoid | Pantoea ananatis
BGC0000640.1 |  | 0.43 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000639.1 |  | 0.39 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000630.1 |  | 0.35 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000648.1 |  | 0.34 | Terpene | carotenoid | Myxococcus xanthus
BGC0000633.1 |  | 0.32 | Terpene | carotenoid | Streptomyces avermitilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000656.1 |  | 0.81 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000647.1 |  | 0.77 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000642.1 |  | 0.76 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000641.1 |  | 0.76 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000638.1 |  | 0.76 | Terpene | carotenoid | Pantoea ananatis
BGC0000640.1 |  | 0.74 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000639.1 |  | 0.71 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000630.1 |  | 0.68 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000648.1 |  | 0.67 | Terpene | carotenoid | Myxococcus xanthus
BGC0000633.1 |  | 0.66 | Terpene | carotenoid | Streptomyces avermitilis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names