LOCUS       c00039_NZ_JRNG..       10375 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JRNG01000039.1 Corynebacterium tuscaniense DNF00037 contig39,
            whole genome shotgun sequence.
ACCESSION   NZ_JRNG01000039
VERSION     NZ_JRNG01000039
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:47:19
            Original ID  :: NZ_JRNG01000039.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 11270
            Orig. end    :: 21645
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10375
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[16270:16645](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5375)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     cand_cluster    1..10375
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10375
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     CDS             complement(169..720)
                     /locus_tag="ctg39_21"
                     /transl_table=11
                     /translation="MCTVTAAGWDAAGRKIALTAGHCGNVGELVAAADSLEAGYSGRIV
                     RKNGALDYAVIELGPNAEVTGSYNGTTIRSLGGWAKTGDTLCKNGYATGVTCGVVWASE
                     PARHVTQVCAMAGDSGAPVYAGDRLVGMINGGMLPQPVNLSCHTPLQGGLHAPTVSRNI
                     DAVMRDLNAAPGPGQGFRLA"
     CDS             926..2275
                     /locus_tag="ctg39_22"
                     /transl_table=11
                     /translation="LATAGTMLSSSAAATILPARFILGPFLPGNFALILSHLLSFPGEP
                     TPSTVTVVRVNQRLIVPDLARGLALLGIAMANISTAWIIADMPGATGEYVGWVQPGNVA
                     DQIAAMFAAMFVHVRGLPMFSTLLGFGVGLITMSLSRKNYPVKKARLVLVKRYGILALF
                     GLVHMFFIFNGDIMVSYGLCGMVLGLLIAVRTKILRIIAYCFIGFSIFMAFLGAVGAAF
                     GQDLMLPLETTDNFTTPAEYFIDNATWGFIMLINAVMANGFLLGVMLIGFIWAREGVLA
                     DVNAHRRTLIIWSALTVAVILLIGIPLGLASIGVFSGRVEAIFIALNQGFGMITGPGIL
                     AMLALATQRLHNKVPVVFYPFVALGKRSMSGYIMQSILFIVTVMPFGLGLGLESGVAIK
                     LLIATGIWAVTLILATILEATNTPGPFEWAHRHLSYGKTGRLEPYTVAHA"
     PFAM_domain     1748..2236
                     /aSDomain="DUF418"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04235.14"
                     /description="Protein of unknown function (DUF418)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_22_0001"
                     /evalue="4.70E-25"
                     /label="ctg39_22"
                     /locus_tag="ctg39_22"
                     /protein_end="437"
                     /protein_start="274"
                     /score="88.5"
                     /tool="antismash"
                     /translation="AREGVLADVNAHRRTLIIWSALTVAVILLIGIPLGLASIGVFSGR
                     VEAIFIALNQGFGMITGPGILAMLALATQRLHNKVPVVFYPFVALGKRSMSGYIMQSIL
                     FIVTVMPFGLGLGLESGVAIKLLIATGIWAVTLILATILEATNTPGPFEWAHRHLSYGK
                     "
     CDS             2262..2900
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280:thiamine-phosphate pyrophosphorylase (Score: 143;
                     E-value: 1.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_23"
                     /transl_table=11
                     /translation="LLMLDLRCYFITGHGSHEQIVETTRQAALGGAGMIQVRSKPISAR
                     ALYDLGLAVVTAVRSVNPSTHVLIDDRVDVALALRPHGVAGVHIGQDDLDPRVARELLG
                     PDAIIGLTTGTLSLVEDANQYVDVIDYIGAGPFRATPTKDSGREPLGLAGYPDLVAASE
                     LPVVAIGDVTVDDVADLAATGVDGVAIVRGIMNAADPRAYVEQVLRNFH"
     PFAM_domain     2283..2843
                     /aSDomain="TMP-TENI"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02581.19"
                     /description="Thiamine monophosphate synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_23_0002"
                     /evalue="1.10E-48"
                     /label="ctg39_23"
                     /locus_tag="ctg39_23"
                     /protein_end="194"
                     /protein_start="7"
                     /score="165.0"
                     /tool="antismash"
                     /translation="CYFITGHGSHEQIVETTRQAALGGAGMIQVRSKPISARALYDLGL
                     AVVTAVRSVNPSTHVLIDDRVDVALALRPHGVAGVHIGQDDLDPRVARELLGPDAIIGL
                     TTGTLSLVEDANQYVDVIDYIGAGPFRATPTKDSGREPLGLAGYPDLVAASELPVVAIG
                     DVTVDDVADLAATGVDGVAIVRGI"
     aSDomain        2283..2879
                     /aSDomain="TIGR00693"
                     /aSTool="tigrfam"
                     /description="thiE: thiamine-phosphate diphosphorylase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_23_0001"
                     /evalue="1.30E-43"
                     /identifier="TIGR00693"
                     /label="ctg39_23"
                     /locus_tag="ctg39_23"
                     /protein_end="206"
                     /protein_start="7"
                     /score="146.5"
                     /tool="antismash"
                     /translation="CYFITGHGSHEQIVETTRQAALGGAGMIQVRSKPISARALYDLGL
                     AVVTAVRSVNPSTHVLIDDRVDVALALRPHGVAGVHIGQDDLDPRVARELLGPDAIIGL
                     TTGTLSLVEDANQYVDVIDYIGAGPFRATPTKDSGREPLGLAGYPDLVAASELPVVAIG
                     DVTVDDVADLAATGVDGVAIVRGIMNAADPRAYVEQ"
     CDS             complement(2897..4156)
                     /locus_tag="ctg39_24"
                     /transl_table=11
                     /translation="MTAILAEPNLLAAHMGAGIIDTYTRMMRCKASLLAQIAEFDNLGL
                     AQDLGATSTGAWLIRRLGISHSTAHEYVAVARQLENFPYLKLMFEEGKLSYSVVRLLLK
                     YLTPENEVELVNRAMELGYHGLEHALAGKPKKGTGEDYPEHYLRLSQDENGDVNVWGKL
                     NAADGEALAAALKIGHLAYCAEEEELAELIDEAGIANLYDQKIEEEKELAKRDKSSFGL
                     PTGRAMMYALMGMVNIVRTNPKNTLRAPAAQVNVMMTVDGNAYLPNNAGAPSTALENIV
                     SNALMKLNIVDRHGQVLNVGRASRLATDKQVKALMAMWGGQCAMPGCIHRRFMEIHHIR
                     EWADGGMTDLDNLLPLCSGCHSLVTDGYVKIQRDRHNIVFDFRDGARFVSYSHSLPVRD
                     DDYECMPVPEDGGDSDSFAG"
     PFAM_domain     complement(3059..3184)
                     /aSDomain="HNH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01844.25"
                     /description="HNH endonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_24_0004"
                     /evalue="3.60E-09"
                     /label="ctg39_24"
                     /locus_tag="ctg39_24"
                     /protein_end="366"
                     /protein_start="324"
                     /score="36.7"
                     /tool="antismash"
                     /translation="MPGCIHRRFMEIHHIREWADGGMTDLDNLLPLCSGCHSLVTD"
     PFAM_domain     complement(3839..4051)
                     /aSDomain="DUF222"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02720.19"
                     /description="Domain of unknown function (DUF222)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_24_0003"
                     /evalue="3.70E-07"
                     /label="ctg39_24"
                     /locus_tag="ctg39_24"
                     /protein_end="106"
                     /protein_start="35"
                     /score="29.9"
                     /tool="antismash"
                     /translation="QIAEFDNLGLAQDLGATSTGAWLIRRLGISHSTAHEYVAVARQLE
                     NFPYLKLMFEEGKLSYSVVRLLLKYL"
     CDS             complement(4393..4962)
                     /locus_tag="ctg39_25"
                     /transl_table=11
                     /translation="VALLNLGYFFVEFAAAIAIGSASLFADSADFLEDTAINMLVFFAV
                     AWPASQRRVAGTVLSGLILIPAVAALVTVVLKIINPEPPSPSGLTGIALGALVVNLICA
                     VILLRLRDQGSSLATGAWLAARNDALANVLIILAGLLTFVWATAWFDIIVAAIIIIVNL
                     SAAKEVWEESREEHDSVEEAFAEMED"
     PFAM_domain     complement(4462..4959)
                     /aSDomain="Cation_efflux"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01545.23"
                     /description="Cation efflux family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_25_0005"
                     /evalue="2.50E-11"
                     /label="ctg39_25"
                     /locus_tag="ctg39_25"
                     /protein_end="167"
                     /protein_start="1"
                     /score="43.8"
                     /tool="antismash"
                     /translation="ALLNLGYFFVEFAAAIAIGSASLFADSADFLEDTAINMLVFFAVA
                     WPASQRRVAGTVLSGLILIPAVAALVTVVLKIINPEPPSPSGLTGIALGALVVNLICAV
                     ILLRLRDQGSSLATGAWLAARNDALANVLIILAGLLTFVWATAWFDIIVAAIIIIVNLS
                     AAK"
     CDS             complement(5001..5375)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_26"
                     /sec_met_domain="ectoine_synt (E-value: 5e-35, bitscore:
                     112.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFIRSREDVETVEWGGGTSERVLTAKDNMGFAVAHTVVRAGTESK
                     LQYRNHLEACYCIAGSGEVEDTEGNVYPITPGTIYVLDEHDAHYLRGGKDEDLILVSIF
                     NPAITGDEKHTLSDDGFSSY"
     PFAM_domain     complement(5031..5363)
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06339.14"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_26_0006"
                     /evalue="4.40E-36"
                     /label="ctg39_26"
                     /locus_tag="ctg39_26"
                     /protein_end="115"
                     /protein_start="4"
                     /score="124.0"
                     /tool="antismash"
                     /translation="SREDVETVEWGGGTSERVLTAKDNMGFAVAHTVVRAGTESKLQYR
                     NHLEACYCIAGSGEVEDTEGNVYPITPGTIYVLDEHDAHYLRGGKDEDLILVSIFNPAI
                     TGDEKHT"
     CDS             complement(5629..5778)
                     /locus_tag="ctg39_27"
                     /transl_table=11
                     /translation="MVIPEAITARIRLSRIERLKPSPLISVSPRHFLSSARTRSLPKTM
                     EKTT"
     CDS             5890..7008
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 218.4;
                     E-value: 2.7e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_28"
                     /transl_table=11
                     /translation="MGGKKESMKVAVVGAGIIGLSTSLTLADHGHQITVYDPAPASGAT
                     WHAGGMLAPAAEVVYQQDPLFPLMIAAGKWYPELIALIQKYTDSPTGYRTEGTLVVAKD
                     RADKTHLEELQEYQQLHGMTTERITTREARKLEPALAPAISGAVHIPGDHQVRPRLIAA
                     ALQEACRNAGVTFEAEAVKDVNDVAADQVLLANGLGARETTGWFEGTNPLKLRPVYGDM
                     VELRVPAHQRPLVERVIRGFVEDRPIYLIPREDGTLTIGATTREDDRPEPQAGGVLQLL
                     RDASEIVPGIEECDIIEIHTGARPGSPDDLPYLGRVNDRVVVSTGYFRHGILLAGVGAR
                     CGAEIVEKLKPSVDLEACNPLRHKENNEADSE"
     PFAM_domain     5914..6921
                     /aSDomain="DAO"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01266.26"
                     /description="FAD dependent oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_28_0007"
                     /evalue="1.10E-53"
                     /label="ctg39_28"
                     /locus_tag="ctg39_28"
                     /protein_end="344"
                     /protein_start="8"
                     /score="183.2"
                     /tool="antismash"
                     /translation="KVAVVGAGIIGLSTSLTLADHGHQITVYDPAPASGATWHAGGMLA
                     PAAEVVYQQDPLFPLMIAAGKWYPELIALIQKYTDSPTGYRTEGTLVVAKDRADKTHLE
                     ELQEYQQLHGMTTERITTREARKLEPALAPAISGAVHIPGDHQVRPRLIAAALQEACRN
                     AGVTFEAEAVKDVNDVAADQVLLANGLGARETTGWFEGTNPLKLRPVYGDMVELRVPAH
                     QRPLVERVIRGFVEDRPIYLIPREDGTLTIGATTREDDRPEPQAGGVLQLLRDASEIVP
                     GIEECDIIEIHTGARPGSPDDLPYLGRVNDRVVVSTGYFRHGILLAGVGARCGAE"
     aSDomain        5917..6930
                     /aSDomain="TIGR02352"
                     /aSTool="tigrfam"
                     /description="thiamin_ThiO: glycine oxidase ThiO"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_28_0002"
                     /evalue="1.10E-105"
                     /identifier="TIGR02352"
                     /label="ctg39_28"
                     /locus_tag="ctg39_28"
                     /protein_end="347"
                     /protein_start="9"
                     /score="351.5"
                     /tool="antismash"
                     /translation="VAVVGAGIIGLSTSLTLADHGHQITVYDPAPASGATWHAGGMLAP
                     AAEVVYQQDPLFPLMIAAGKWYPELIALIQKYTDSPTGYRTEGTLVVAKDRADKTHLEE
                     LQEYQQLHGMTTERITTREARKLEPALAPAISGAVHIPGDHQVRPRLIAAALQEACRNA
                     GVTFEAEAVKDVNDVAADQVLLANGLGARETTGWFEGTNPLKLRPVYGDMVELRVPAHQ
                     RPLVERVIRGFVEDRPIYLIPREDGTLTIGATTREDDRPEPQAGGVLQLLRDASEIVPG
                     IEECDIIEIHTGARPGSPDDLPYLGRVNDRVVVSTGYFRHGILLAGVGARCGAEIVE"
     CDS             6989..7189
                     /locus_tag="ctg39_29"
                     /transl_table=11
                     /translation="MKLTVNNEAVTTKATTVKGLLEEVLGDVPAGTAVAVDGNVVPKSQ
                     WDTHGLDEGARVDILTAVQGG"
     aSDomain        6995..7186
                     /aSDomain="TIGR01683"
                     /aSTool="tigrfam"
                     /description="thiS: thiamine biosynthesis protein ThiS"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg39_29_0003"
                     /evalue="1.60E-18"
                     /identifier="TIGR01683"
                     /label="ctg39_29"
                     /locus_tag="ctg39_29"
                     /protein_end="66"
                     /protein_start="2"
                     /score="64.8"
                     /tool="antismash"
                     /translation="LTVNNEAVTTKATTVKGLLEEVLGDVPAGTAVAVDGNVVPKSQWD
                     THGLDEGARVDILTAVQGG"
     PFAM_domain     7007..7186
                     /aSDomain="ThiS"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02597.22"
                     /description="ThiS family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_29_0008"
                     /evalue="1.40E-11"
                     /label="ctg39_29"
                     /locus_tag="ctg39_29"
                     /protein_end="66"
                     /protein_start="6"
                     /score="44.9"
                     /tool="antismash"
                     /translation="NEAVTTKATTVKGLLEEVLGDVPAGTAVAVDGNVVPKSQWDTHGL
                     DEGARVDILTAVQGG"
     CDS             7192..7968
                     /locus_tag="ctg39_30"
                     /transl_table=11
                     /translation="VLDIAGKQFNSHLIMGTGGASSQDMLERALVASGTELTTVAMRKF
                     AAPAGESVFDLLSRLGIAPLPNTAGCRTARDAVITAKLAREALGTDWVKLEVIADDRTL
                     LPDVVETVDACEMLIGEGFTVLAYTSDDPVAAKRLEDLGAAAVMPLGAPIGTGLGILNP
                     HNIELICSRAEVPILIDAGVGTASDAALAMELGCDGVLLASAVNRCQDPVSMAQAMRLA
                     VEAGLLARGAGRIPKREHAVASSSFDGLVSWADQVL"
     PFAM_domain     7201..7929
                     /aSDomain="ThiG"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05690.16"
                     /description="Thiazole biosynthesis protein ThiG"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_30_0009"
                     /evalue="1.10E-103"
                     /label="ctg39_30"
                     /locus_tag="ctg39_30"
                     /protein_end="246"
                     /protein_start="3"
                     /score="345.9"
                     /tool="antismash"
                     /translation="IAGKQFNSHLIMGTGGASSQDMLERALVASGTELTTVAMRKFAAP
                     AGESVFDLLSRLGIAPLPNTAGCRTARDAVITAKLAREALGTDWVKLEVIADDRTLLPD
                     VVETVDACEMLIGEGFTVLAYTSDDPVAAKRLEDLGAAAVMPLGAPIGTGLGILNPHNI
                     ELICSRAEVPILIDAGVGTASDAALAMELGCDGVLLASAVNRCQDPVSMAQAMRLAVEA
                     GLLARGAGRIPKREHAVASSS"
     CDS             complement(8460..9740)
                     /locus_tag="ctg39_31"
                     /transl_table=11
                     /translation="MWVIFTLPGLAMGYFIYKRKMPARYSSMFSPLLGSKVYEWPGKLL
                     DAVGIIGTVFGLAVSVGLGVLQISAGLNIMFDVPLVTWVQLVIIIAITLAASISVATGL
                     DKGVKLLSNLNIIGSIALLVFLFIAGPTLKIIGHITESFGIYANSLPELMFWVDSNGEN
                     PGWHATWTAFYWAWTICWSPYVGMFFARISRGRSVREFIGGTIMLPTMFDIIWFATFGR
                     AALEVEKENPGVLTGPVVEDGDTPQALFTLLAQYPLYVVTGTVALAVIVFYFVTSIDSA
                     AMVMDMFATGEEEKSPGYYRVAWACSVGVVTAALLFINDSGIQALQEVVIIIALPFFFV
                     YFIMMYALIKAMSDDASADRRFRSRKWEKTDTAEKYEEAEAKPAPGYDEEGNQIDRPEL
                     EYDYENETWRLTEALVVDGETPESKQD"
     PFAM_domain     complement(8679..9737)
                     /aSDomain="BCCT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02028.19"
                     /description="BCCT, betaine/carnitine/choline family
                     transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg39_31_0010"
                     /evalue="4.50E-119"
                     /label="ctg39_31"
                     /locus_tag="ctg39_31"
                     /protein_end="354"
                     /protein_start="1"
                     /score="398.2"
                     /tool="antismash"
                     /translation="WVIFTLPGLAMGYFIYKRKMPARYSSMFSPLLGSKVYEWPGKLLD
                     AVGIIGTVFGLAVSVGLGVLQISAGLNIMFDVPLVTWVQLVIIIAITLAASISVATGLD
                     KGVKLLSNLNIIGSIALLVFLFIAGPTLKIIGHITESFGIYANSLPELMFWVDSNGENP
                     GWHATWTAFYWAWTICWSPYVGMFFARISRGRSVREFIGGTIMLPTMFDIIWFATFGRA
                     ALEVEKENPGVLTGPVVEDGDTPQALFTLLAQYPLYVVTGTVALAVIVFYFVTSIDSAA
                     MVMDMFATGEEEKSPGYYRVAWACSVGVVTAALLFINDSGIQALQEVVIIIALPFFFVY
                     FIMMYALIKAMSD"
     CDS             9763..10161
                     /locus_tag="ctg39_32"
                     /transl_table=11
                     /translation="VNSNAWRMAPGLMDSKSPRGGLKEWCSGSAAPQNIRVAPMPAANS
                     MENQTGREYSGSSSSSPSLKLPYLDTKTTMRKTNTVETPPMYSHAKLSIIQPETCEYVA
                     RARSPKMMVAATKMVMNPAATPKIRGSD"
ORIGIN
        1 tggatattgc tgcagagccg gaagtctccc tgtgggacct ggcgccgcta gcgatcctgg
       61 tgactgaggc cggcgggcgt ttcacttcct tggctggtga ggatggcccg cacggtggcg
      121 atgccctggc cacgaacggc ctgcttcacg agggcgttcg ccaacgcctt acgcgagcct
      181 aaaaccctgc cccggccccg gtgcggcgtt gaggtcccgc atcacggcgt caatattgcg
      241 cgagaccgtc ggcgcgtgaa ggccaccctg tagaggtgtg tggcacgaca agttcaccgg
      301 ctgtggcagc atcccaccgt tgatcatgcc gaccaaccgg tcccccgcat acaccggggc
      361 accggagtct cccgccatcg cgcacacctg cgtgacgtgg cgggccggct cagacgccca
      421 caccacgccg caggtcacgc ccgtggcata gccgttcttg cacagcgtgt caccggtctt
      481 agcccagcca ccgagcgagc ggatcgtcgt gccgttgtag ctgcccgtca cttccgcatt
      541 ggggccaagc tcaatcacgg cgtagtccag cgcgccattc ttgcgcacga tgcggcccga
      601 gtagccagcc tccagcgaat ccgccgcggc caccagctcc cccacgttgc cgcagtggcc
      661 ggccgtcagc gcgatcttcc tgccggccgc atcccagcca gctgcagtga cggtgcacat
      721 gccgaactgt cccacgtaaa tcggcgtgcc gggcccgtat agcgatgtgc ccctgcccac
      781 cgccgcacgg gccgcggggt ttactgggtt ggcgtcaaag aacgaccccg gcacacggtt
      841 gagcacccgg tccgcaaacg gcttgcccgc catcaccttg gacaccgggt ccgtcttcca
      901 gtggtagttc ggatccacct gcgcattggc caccgcgggc accatgctga gcagcagcgc
      961 tgccgccaca attcttccgg cacgtttcat cctcggcccc ttcctgcctg gtaatttcgc
     1021 actaatcttg tcacacctct tgtcctttcc cggtgagccc acccccagta ctgttactgt
     1081 ggtgcgggtg aatcaacgac tcatcgttcc tgaccttgcc cgtggccttg cattgctggg
     1141 catcgccatg gcaaatattt ccactgcctg gatcatcgct gacatgcctg gcgcgactgg
     1201 cgaatatgtc ggctgggtcc agcccggcaa tgtggccgac caaatcgcgg cgatgtttgc
     1261 cgccatgttt gtccacgtgc gtggcctacc catgttctcc acgctgcttg gcttcggtgt
     1321 cggcctgatc accatgagcc tgtcgcggaa gaactacccg gtaaagaagg cccgactcgt
     1381 gctggtgaaa cggtacggca tcctggctct cttcggcctt gtgcacatgt tcttcatctt
     1441 caacggtgac atcatggtct cctacggcct gtgtggcatg gttctgggct tgctcattgc
     1501 cgtgcgcaca aagatcttgc ggatcattgc ctactgcttc attggcttct ccatcttcat
     1561 ggccttcctc ggcgccgttg gtgctgcatt cggtcaggac ctgatgcttc ccctagagac
     1621 gacggacaac ttcaccaccc ccgctgagta cttcatcgat aacgccacct ggggcttcat
     1681 catgctcatc aatgcggtga tggctaacgg tttcctcctc ggcgtgatgc tcatcggttt
     1741 catttgggct cgcgaaggcg tgctcgctga cgtcaacgca caccgtcgca ccctgatcat
     1801 ctggtccgcc ctaaccgtgg ccgtcatcct tctcattggc atcccgttgg gtctggcctc
     1861 catcggcgtg ttcagcgggc gcgttgaagc cattttcatt gccctcaacc aaggcttcgg
     1921 catgatcacc ggtcccggca tcctggccat gctcgcgtta gccacccagc gcctgcataa
     1981 caaggtcccc gtggtgttct accccttcgt cgcactgggc aagcgttcca tgtccggcta
     2041 catcatgcag tccatcctct tcatcgtcac agtcatgccc ttcggcctcg gcctgggcct
     2101 cgaatccggc gttgccataa agctgctcat cgccaccggc atctgggcag tcaccctgat
     2161 cctggccacg atcctggagg ccaccaacac cccgggcccc ttcgagtggg cacaccgtca
     2221 cctctcctac ggcaagaccg gccgcttgga gccctacact gttgctcatg cttgatctgc
     2281 gctgttattt catcaccggc cacggctcgc acgagcagat cgtggaaacc acccgccaag
     2341 ccgccctcgg cggcgccggc atgatccaag tgcgcagcaa acccatcagc gcccgcgcgc
     2401 tctacgacct gggcctcgcc gtcgtcaccg cagtgcgttc agtgaaccct tccacgcacg
     2461 tgcttatcga cgatcgcgtc gacgtcgccc tcgccctccg cccccacggc gtggctggtg
     2521 tccacatcgg ccaagacgac ctagacccac gcgtggcacg ggaactgctt ggccctgacg
     2581 caatcatcgg cctgaccacc ggcacgcttt cactcgttga ggatgcgaac cagtacgtcg
     2641 atgtcatcga ctacatcggt gccggcccct tccgcgccac cccgaccaag gattctggcc
     2701 gcgaaccgct gggccttgct ggctaccccg acctcgtcgc tgcctccgag ctacctgtcg
     2761 tggccattgg cgatgtcacc gtcgatgacg tggccgacct cgccgccacc ggcgtcgacg
     2821 gcgttgccat cgtgcgcggc atcatgaacg ccgctgatcc acgcgcctac gtggagcagg
     2881 tcctgcgcaa cttccactaa ccggcgaacg agtctgaatc acccccgtcc tccgggaccg
     2941 gcatgcactc atagtcatcg tcccgcactg gcagagagtg gctgtaggag acgaaccgcg
     3001 ccccgtcccg gaaatcgaag acgatgttgt gacgatctcg ctggatcttc acgtagccgt
     3061 ccgtgaccag cgagtggcag ccggaacaca gcggcaaaag gttgtccaag tccgtcatgc
     3121 caccatctgc ccactcgcga atgtggtgga tctccatgaa gcgccgatgg atgcatcctg
     3181 gcatggcaca ctggccaccc cacattgcca tcagcgcttt gacttgcttg tctgtggcca
     3241 gccgtgaggc ccggccgacg ttgaggacct gcccatgccg gtccacgatg ttcagcttca
     3301 ttagcgcgtt agacacgatg ttctccagtg cggtggacgg tgccccagca ttgttaggca
     3361 ggtaggcgtt accgtccacc gtcatcatca cgttcacctg cgcagctggt gcgcgcagcg
     3421 tgttcttcgg gttcgtgcgc acgatgttca ccattcccat gagcgcgtac atcattgccc
     3481 gtccggtagg gagcccgaaa ctggatttgt cccgcttcgc aagctccttc tcctcctcta
     3541 ttttctggtc gtagaggttg gcgatgccgg cttcgtcgat aagctcggca agctcttctt
     3601 cctccgcgca gtacgcgagg tgcccgatct tgagtgccgc tgccagtgct tccccgtcag
     3661 cggcgttgag ttttccccac acgttcacgt cgccgttctc atcctggctc aagcggagat
     3721 aatgctccgg gtagtcctca cccgtgccct ttttcggctt gccggcgagc gcatgctcca
     3781 gcccgtggta gccgagctcc atcgcacgat tgaccagctc aacctcattt tcaggggtga
     3841 gatatttgag caggaggcgc accacggaat agctgagctt gccctcctcg aacatcagct
     3901 tgaggtacgg gaagttctcc agctgccgcg caaccgcaac gtattcgtgg gcggtggaat
     3961 gggatatgcc taatcttcgg attaaccacg cgcccgtgct cgtagcaccg agatcctggg
     4021 ccaatccgag gttgtcgaac tcagctatct gcgccaaaag tgacgctttg cagcgcatca
     4081 tcctggtgta agtgtcaatg atccccgcac ccatatgcgc agctagaagg ttcggttccg
     4141 caagtattgc tgtcatggtg tccccttgtt ggttcgttgt gaaggtgttg tgggaacacc
     4201 atacaaaacg agtacgacac aattcgaaca gcaattcgaa cacaacctaa gagaatgagt
     4261 ccgcattgcg gactccctgg ggctttgtgt tcacgccaaa acgtaggcct cagacgcgcc
     4321 gcaaaacaca tcgagcacgt attcgaaact aacctaagaa aaagagtccg cattgcggac
     4381 tccctgggaa aactaatcct ccatctccgc gaaagcctcc tccacggagt catgctcttc
     4441 acgggattcc tcccacactt ccttcgcagc agagaggttc acgatgatga tgatcgctgc
     4501 gacgataatg tcgaaccagg cggtggccca cacgaaggtg agcaggccgg cgaggatgat
     4561 gaggacgttg gccaaggcgt cgttacgcgc tgcgagccac gcccccgtcg ccagcgacga
     4621 accctgatcg cgaaggcgca acaagatcac ggcgcagatc agattgacca cgagagcgcc
     4681 gagcgcgatg ccagttagac ccgacggcga cggcggctcc gggttgatta tcttcagaac
     4741 tacggtcacc agcgcggcaa cagccggaat aaggatgagg ccggaaagaa cagtgccggc
     4801 cacgcgacgc tgagaagctg gccacgccac cgcgaagaac acaagcatgt tgattgctgt
     4861 gtcttcgagg aagtctgcgg aatccgcgaa gagggaggct gagccgatcg cgatggcggc
     4921 tgcgaactcg acgaagaagt agccgagatt cagcagcgcc acgatcagaa cggcgcgccg
     4981 aatacgctgt tcagtcatgg ttagtagctg ctgaacccgt cgtcggaaag cgtgtgcttt
     5041 tcgtcgccag ttatcgccgg gttgaagata gagaccagga tcagatcctc gtctttgccg
     5101 ccacgcaggt agtgcgcgtc gtgctcgtcg aggacgtaaa tcgtgcccgg ggtgatcggg
     5161 tacacgttgc cctcggtgtc ctcgacctcg ccggagccgg cgatgcagta gcaggcttcg
     5221 aggtggttgc ggtactgcag tttggactcg gtgccggcgc gcacgacggt gtgcgcgaca
     5281 gcgaagccca tgttgtcttt cgcggtgagc acgcgctcgg aggtgccgcc accccactca
     5341 acagtttcga catcttctcg ggaacgaatg aacatgaatc tccttccagt tacccgttcc
     5401 acggtacgcg taagctcgtg ggcatgattc ttgccatcat caccgcagaa gttgcgttct
     5461 ggctctgttt gtttggcgga atgttcctgc gctacgccct taagttgcct aaagcaggaa
     5521 ttgtgctgct agcggcaacc ccctcattga ccttgcttta ctcgtttaca cgttttggag
     5581 tctggccgat acgcaccacg caaatttttt ccacgcgttc ggcgctttct acgtcgtttt
     5641 ttccattgtt ttcggcaaag atctggttct cgcactggac aagaagtggc gtggtgagac
     5701 agagatcagt ggtgagggct tcagccgctc gatccgcgac aatctgatac gcgcggttat
     5761 tgcctccggg atcaccatcc tcatcctcgt agccatggtc tttgttacag gcatcgccgg
     5821 tagtttttgg ttgttctatt ggatcattgc tatggcgttt ctgccggcct gctggtggac
     5881 aatcgataaa tgggtggaaa gaaggaaagc atgaaggtcg cagtagtagg cgcaggaatt
     5941 attggcttat cgacgagcct caccctcgcc gaccacggcc accagatcac cgtgtacgac
     6001 ccagcaccag ctagtggtgc cacgtggcat gcgggaggga tgctcgcccc ggctgcggag
     6061 gtggtctacc agcaggaccc gctgttccca ctgatgatcg cggctgggaa gtggtatccg
     6121 gagctcatcg cgctcattca gaaatacacg gactctccca ccggctaccg cacggaggga
     6181 acactggtgg tggccaagga ccgtgcggat aagacacatc tagaggagct gcaggagtat
     6241 cagcagctgc acgggatgac cacggagcgc atcactacgc gggaggcccg gaagctggag
     6301 ccggcactcg cccccgccat tagcggtgcc gtgcacattc cgggcgacca ccaggtgcgc
     6361 ccgcggctca tcgcggcggc actgcaggaa gcgtgccgca atgccggggt gacgttcgag
     6421 gcggaggcgg tgaaagatgt caacgatgtc gcagctgatc aggtgctgct ggccaacggt
     6481 ttgggggcgc gcgaaacaac gggctggttc gagggcacga acccgttgaa gctgcgcccg
     6541 gtgtacggcg acatggtgga gctgcgcgtc ccggcacacc aacggccact ggttgagcgg
     6601 gtcatccgcg ggttcgtgga ggaccgaccg atctatctca tcccccgcga agacggcacg
     6661 ctgaccatcg gcgccaccac ccgcgaggat gatcgccctg agccgcaggc aggcggcgtt
     6721 ctgcaactgc tgcgggacgc cagtgagatc gtgccgggta tagaggaatg cgacatcatc
     6781 gaaatccaca ccggcgcccg gcctggttcc ccggatgatc tgccctacct cggccgggtc
     6841 aatgaccggg tggttgtatc caccggctac ttccgccacg ggatcctgtt ggcgggggtg
     6901 ggggctaggt gtggggcgga gatcgtcgag aagctcaagc cctccgtaga cttggaggcc
     6961 tgtaacccgc tgaggcacaa ggagaacaat gaagctgaca gtgaataatg aagcggtcac
     7021 cacgaaagcg accaccgtga agggcctgct ggaggaggtt ctgggcgacg ttcctgctgg
     7081 cactgccgtc gccgtcgatg ggaatgttgt accgaagtca cagtgggaca cgcatggact
     7141 ggacgaaggc gcccgcgtgg atattctcac cgctgttcag ggaggctaaa cgtgctggac
     7201 attgccggca agcagttcaa ttcccaccta atcatgggca cgggcggagc aagctcgcag
     7261 gacatgctcg agcgcgcgct cgtcgcgtcg ggcacggagt tgactacggt ggccatgcgg
     7321 aaattcgccg ctcccgcagg cgagtctgtt tttgatctgc tctcccgcct cggtatcgcg
     7381 ccactgccaa acaccgcggg gtgtcgcacc gcgcgagatg cggtgatcac ggcgaagctt
     7441 gcgcgtgagg cgctgggcac ggactgggtg aaactagaag tcatcgccga tgatcgcacg
     7501 ctcctgcccg atgttgtgga gaccgtcgat gcgtgcgaga tgcttatcgg cgaaggcttc
     7561 accgtcctcg cctacacctc cgacgaccct gtcgcggcga agcggctgga agacctcggt
     7621 gcggctgcgg tcatgccact gggcgcacca attggtaccg gcttgggaat tttgaacccg
     7681 cacaacatcg agctgatttg ttcgcgggca gaggtgccca tcctcattga tgctggtgtg
     7741 ggcactgcct ccgatgcggc gctagcgatg gagcttggct gcgacggtgt gctgctggct
     7801 agtgccgtca accgctgcca agacccggtg tctatggcgc aggcgatgcg cctggccgtg
     7861 gaggcggggc tacttgcgcg tggggcgggg cggattccga agagggagca cgcggtggca
     7921 tcctcaagct ttgatggcct agtcagctgg gcagaccagg ttttgtaacc gaaaactccg
     7981 tagaatgtaa ctaacggggt cacacggacc cccgcgctac accaaggagt tccaccatga
     8041 aacgcacaac aacggttctt ggcaccgcgg tccttgccgc cggacttgcc accgccgcgt
     8101 tcgctccgaa tgcggcagct aatccgaact acgtctccaa cgccaacaac accgtccgct
     8161 gctacataac ggaaggtgaa acactctgcg tcagcgacat cggccgtgac gcacaaccgg
     8221 agtgcaaccc gccgggccat ctgatcccag ccgtgtccat ccagcgtaac tgggtgggca
     8281 ccaagtgctg gaaccagggc tttgacggcc agccgatgcg cctcaacccg ctgcagattc
     8341 acgtcaacgg cagccgggtt gtcatccctg gcctcgcggg cgagctgtat gtccttgacg
     8401 tggcaaagcc ggcactggtt cgcgccggct cccacaatgc agtgctgttc gccctctaat
     8461 tagtcctgct tggactcagg cgtctcaccg tccaccacga gtgcttcggt gaggcgccac
     8521 gtctcgttct cgtagtcgta ctcgagctcg gggcggtcaa tctggttgcc ttcttcgtca
     8581 tagccagggg ccggcttggc ttcggcttcc tcatatttct ctgccgtgtc ggtcttctcc
     8641 cacttacggg aacggaagcg acggtcagct gaagcatcgt cgctcatagc cttgatcagc
     8701 gcgtacatca tgatgaagta cacgaagaag aatggcaggg cgatgatgat caccacttct
     8761 tgtagtgcct gaatgccgga gtcgttgatg aacagcagcg ctgctgtgac cacaccgacg
     8821 gaacatgccc aggcgacacg gtagtagccc ggggattttt cttcctcacc agtggcaaac
     8881 atgtccatga ccatcgctgc ggagtcgatg gatgtaacga agtagaacac aatcacagcc
     8941 agggcgaccg tgccggtgac cacgtacagc gggtactgcg ccagcaaggt aaatagtgcc
     9001 tgtggtgtat cgccgtcttc cacgacaggg ccggtgagca cacccgggtt ctccttttcc
     9061 acctcaaggg cagcgcgacc gaaggtggca aaccagatga tgtcaaacat ggtgggcagc
     9121 atgatcgtgc cgccgatgaa ttcgcggacg ctgcggccac gggaaatgcg ggcgaagaac
     9181 atgcccacgt acggcgacca acagatagtc catgcccagt agaacgcggt ccaggtggcg
     9241 tgccagcccg ggttctcacc gtttgaatcc acccagaaca tcagctccgg cagcgagttg
     9301 gcgtagatgc caaaggattc cgtgatgtgc ccaatgatct tcagtgttgg gcccgcgatg
     9361 aaaagaaaca ccagcaaagc gatcgagcca atgatgttca ggttggacag cagcttcacg
     9421 cccttatcca gcccggtggc cacggagatg gaggcagcca gggtgatggc aatgatgatt
     9481 accagctgca cccacgtcac cagcgggacg tcgaacatga tgttcaggcc agcactaatc
     9541 tgcagcacgc caagaccaac ggagacggcg aggccgaaga cggtaccgat gatgccgacg
     9601 gcgtcgagaa gcttgcctgg ccactcgtac actttggagc cgagcagcgg agagaacatc
     9661 gaggagtagc gcgcgggcat cttacgcttg taaatgaagt agcccatagc caggccaggc
     9721 agggtaaaga tcacccacat gtgaataccg aagtggtagt aggtgaactc aaacgcttgg
     9781 cggatggcgc cggggctcat ggattcaaag tcgccgcgcg gcgggttaaa ggagtggtgc
     9841 agcggttcag ccgcacccca gaacatcagg gttgcgccca tgccggcggc aaacagcatg
     9901 gagaaccaga cggggaggga atactccggg tcatcgtcat catcgccgag tttgaagttg
     9961 ccgtatttag atacgaaaac aacaatgagg aagacgaaca ccgtggaaac accaccgatg
    10021 tacagccacg cgaagttgtc catcatccag ccggagacct gcgagtatgt cgcacgggca
    10081 cgctcgccga aaatgatggt ggcggccacg aagatggtga tgaaccccgc ggcaacaccg
    10141 aagatcagag ggtctgattg aaatctaggt ttcctaggca tgccgatcaa gcttatgtta
    10201 aaagcgtgac tatcgcccat cagattcctg aaaaagagtt tcaacgcacc gctcgccaga
    10261 tgaatttgcc gggtttcggc cccgcgcaac aggcagcgct ccatgccgca catgtgctgg
    10321 tcatcggggc gggcggcctc ggctgcccca tcatgcaaac gctcgccgcg acggg
//
