LOCUS       NZ_CP040990.1          10864 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP040990.1 Vibrio furnissii strain FDAARGOS_777 chromosome 1,
            complete sequence.
ACCESSION   NZ_CP040990
VERSION     NZ_CP040990.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:00:33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 589764
            Orig. end    :: 600628
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10864
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[594764:595628](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5864)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10864
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10864
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(231..1070)
                     /locus_tag="ctg1_536"
                     /transl_table=11
                     /translation="LLSYRHSFHAGNHADVVKHIVQSLILSALQQKDKPFVYHDTHSGV
                     GRYDLTHEWSEKTGEYKQGIARLWQQTEVPEDIHSYLEAIKALNDDGELRYYPGSPRVA
                     RAHLRSHDRMVLTELHPSDYPLLEQEFHRDRQVAIFKEDGFARLKASLPPKERRGLVLI
                     DPPYELAKEYRDVVQAIAQSYKRWATGIYAIWYPVVNRCDIEDMIEGLQGLGIRKILQI
                     ELGVSPDTNERGMTASGMIVINPPWKLESQMQSILPFLKEAIAPATGHYKVDWIVPE"
     PFAM_domain     complement(240..974)
                     /aSDomain="RsmJ"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04378.15"
                     /description="Ribosomal RNA large subunit methyltransferase
                     D, RlmJ"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_536_0027"
                     /evalue="7.80E-120"
                     /label="ctg1_536"
                     /locus_tag="ctg1_536"
                     /protein_end="277"
                     /protein_start="32"
                     /score="398.7"
                     /tool="antismash"
                     /translation="DKPFVYHDTHSGVGRYDLTHEWSEKTGEYKQGIARLWQQTEVPED
                     IHSYLEAIKALNDDGELRYYPGSPRVARAHLRSHDRMVLTELHPSDYPLLEQEFHRDRQ
                     VAIFKEDGFARLKASLPPKERRGLVLIDPPYELAKEYRDVVQAIAQSYKRWATGIYAIW
                     YPVVNRCDIEDMIEGLQGLGIRKILQIELGVSPDTNERGMTASGMIVINPPWKLESQMQ
                     SILPFLKEAIAPATGHYKVDWIV"
     CDS             1333..3375
                     /locus_tag="ctg1_537"
                     /transl_table=11
                     /translation="MSNPLLTFTDLPPFSAIKPEHVKPAVEKAIEDCRARIDAVLAGNA
                     EPSWESVIAPIEEVDDRLSRIWSPVSHMNSVMNSDELRDAYESCLPILSEYSTWVGQHK
                     GLFDAYKAIKASKAFATLSRAQQKTITDGLRDFELSGIGLPAAEQKRYGEISKRMSELG
                     SKFSNNVLDATMGWTKQVTDVNELSGMPESALAAAQAAAEAKGLEGYLLTLDIPSYLPV
                     MTYCDNQALRQELYEAYVTRASERGPNAGKWDNSEIIAEQLKLRHEISRMLGFNTYSEK
                     SLATKMAESPEQVLSFLNDLATKAKPQGEREVEALRQFAEQEFGVTTLNLWDIAYYSEK
                     QKQHLFEISDEELRPYFPEHKVVSGLFEVLHRVFGMDVKERQGVDTWHESVRFFDIFDS
                     EGALRGSFYLDLYAREHKRGGAWMDECRVRRINVDGALQTPVAYLTCNFNRPVGNKPAL
                     FTHDEVVTLFHETGHGIHHMLTQVEVGSVSGINGVPWDAVELPSQFLENWCWEEEALAF
                     ISGHYETGEPLPKAMLEKMLAAKNFQSAMFILRQLEFGLFDFTLHTTYDPEAGPKVLET
                     LADVKKKVAVLPSLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVLSADAFSRFEEEGIFN
                     RETGLSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHAGIAA"
     PFAM_domain     1453..1770
                     /aSDomain="TOP_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF19310.1"
                     /description="Neurolysin/Thimet oligopeptidase, N-terminal
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_537_0028"
                     /evalue="6.50E-28"
                     /label="ctg1_537"
                     /locus_tag="ctg1_537"
                     /protein_end="146"
                     /protein_start="40"
                     /score="97.1"
                     /tool="antismash"
                     /translation="LAGNAEPSWESVIAPIEEVDDRLSRIWSPVSHMNSVMNSDELRDA
                     YESCLPILSEYSTWVGQHKGLFDAYKAIKASKAFATLSRAQQKTITDGLRDFELSGIGL
                     PA"
     PFAM_domain     1996..3363
                     /aSDomain="Peptidase_M3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01432.22"
                     /description="Peptidase family M3"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_537_0029"
                     /evalue="1.40E-162"
                     /label="ctg1_537"
                     /locus_tag="ctg1_537"
                     /protein_end="677"
                     /protein_start="221"
                     /score="542.2"
                     /tool="antismash"
                     /translation="VMTYCDNQALRQELYEAYVTRASERGPNAGKWDNSEIIAEQLKLR
                     HEISRMLGFNTYSEKSLATKMAESPEQVLSFLNDLATKAKPQGEREVEALRQFAEQEFG
                     VTTLNLWDIAYYSEKQKQHLFEISDEELRPYFPEHKVVSGLFEVLHRVFGMDVKERQGV
                     DTWHESVRFFDIFDSEGALRGSFYLDLYAREHKRGGAWMDECRVRRINVDGALQTPVAY
                     LTCNFNRPVGNKPALFTHDEVVTLFHETGHGIHHMLTQVEVGSVSGINGVPWDAVELPS
                     QFLENWCWEEEALAFISGHYETGEPLPKAMLEKMLAAKNFQSAMFILRQLEFGLFDFTL
                     HTTYDPEAGPKVLETLADVKKKVAVLPSLEWNRFSHSFSHIFAGGYSAGYYSYLWAEVL
                     SADAFSRFEEEGIFNRETGLSFLNHILEMGGSEEPMELFKRFRGREPQIDALLRHAG"
     CDS             3541..3780
                     /locus_tag="ctg1_538"
                     /transl_table=11
                     /translation="MKGIQSVRWGQVLSMSALLALLTLTAGCAEMRQAGTDVGHATRDA
                     ATAIGHATRDTTKAIGHATRDAVNSVKDDLNAAE"
     CDS             complement(3764..4222)
                     /locus_tag="ctg1_539"
                     /transl_table=11
                     /translation="MADFMHRYHALCHWLQRDFASLLLLLCRIWAGWVFWQSGVSKIAN
                     WDSTLYLFELEYQVPLLPWQLAAYLATGAELALPLLLMPGLFGRFSALALFAVNAMAVV
                     SYPLLWEQGFTDHQLWGFMLLMVVVWGPGRLSLDHWLSRKWQRVILQH"
     PFAM_domain     complement(3911..4156)
                     /aSDomain="DoxX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07681.14"
                     /description="DoxX"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_539_0030"
                     /evalue="7.20E-16"
                     /label="ctg1_539"
                     /locus_tag="ctg1_539"
                     /protein_end="104"
                     /protein_start="22"
                     /score="58.7"
                     /tool="antismash"
                     /translation="LLLLCRIWAGWVFWQSGVSKIANWDSTLYLFELEYQVPLLPWQLA
                     AYLATGAELALPLLLMPGLFGRFSALALFAVNAMAVV"
     CDS             complement(4237..5004)
                     /locus_tag="ctg1_540"
                     /transl_table=11
                     /translation="MTLAQLQAQFARGLNYQAGGDACAIIADGLSADERLQIYRNNRVI
                     SLSEVLEATYPMLLAVLGDECFAALAREYVLSHPLTRGDVSHYGAGFAAVIERAQPVMQ
                     AAPYAAALARFEWALDHVQQQYAQAPRNDCQPLSTLSQVTPEQQPQLVFELVPWATPFC
                     APFALFDLQRAMRDDDFSQLTINALQSGIITCTAEGEPWTQALDEPTYQLLLAMHQRAP
                     LGQIHPDALAALPAIMAMEIVAGFRVAAPNTHD"
     PFAM_domain     complement(4720..4992)
                     /aSDomain="DUF2063"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09836.11"
                     /description="Putative DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_540_0031"
                     /evalue="1.00E-20"
                     /label="ctg1_540"
                     /locus_tag="ctg1_540"
                     /protein_end="95"
                     /protein_start="4"
                     /score="73.9"
                     /tool="antismash"
                     /translation="QLQAQFARGLNYQAGGDACAIIADGLSADERLQIYRNNRVISLSE
                     VLEATYPMLLAVLGDECFAALAREYVLSHPLTRGDVSHYGAGFAAV"
     CDS             complement(5001..5864)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_541"
                     /sec_met_domain="DUF692 (E-value: 1.5e-88, bitscore: 294.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSTHSHPLVGVGLRSPHMSHFLSQPTPLNWLEIHSENYFQPHAP
                     ARRDLRRLRERYDISCHGIGLSLGSVAAVNTQHLAQLKTLVDDIDPILISDHLSWSENG
                     GHYFNDLLPLPYTEEALAVFCRNVDQVQHALGRPLLIENPSSYLRFSHSTIPEWEFLRA
                     VQQRTDCRLLLDLNNVHVSAFNHGFDSQTYLDAIPASAVAEIHLAGYAVKTLPQGDIWI
                     DTHSRPVSDAVWQLFERWCRQHGTRRTLIEWDLEIPAPEVLLGEAHQAAARLHAIDAER
                     GIRSAS"
     PFAM_domain     complement(5046..5837)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_541_0032"
                     /evalue="5.20E-104"
                     /label="ctg1_541"
                     /locus_tag="ctg1_541"
                     /protein_end="273"
                     /protein_start="9"
                     /score="347.2"
                     /tool="antismash"
                     /translation="VGVGLRSPHMSHFLSQPTPLNWLEIHSENYFQPHAPARRDLRRLR
                     ERYDISCHGIGLSLGSVAAVNTQHLAQLKTLVDDIDPILISDHLSWSENGGHYFNDLLP
                     LPYTEEALAVFCRNVDQVQHALGRPLLIENPSSYLRFSHSTIPEWEFLRAVQQRTDCRL
                     LLDLNNVHVSAFNHGFDSQTYLDAIPASAVAEIHLAGYAVKTLPQGDIWIDTHSRPVSD
                     AVWQLFERWCRQHGTRRTLIEWDLEIPAPEVLLGEAHQAAAR"
     CDS             complement(5943..6203)
                     /locus_tag="ctg1_542"
                     /transl_table=11
                     /translation="MKQSNLAVTAAITGLLAMGGTLLTAAPAAAAEKEKCYGVAKAGKN
                     DCATKSSSCAGTSKMDHQKDAFVVVPKGLCDKLAGGSTMAK"
     PFAM_domain     complement(5958..6107)
                     /aSDomain="DUF2282"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10048.11"
                     /description="Predicted integral membrane protein
                     (DUF2282)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_542_0033"
                     /evalue="2.40E-23"
                     /label="ctg1_542"
                     /locus_tag="ctg1_542"
                     /protein_end="82"
                     /protein_start="32"
                     /score="82.0"
                     /tool="antismash"
                     /translation="KEKCYGVAKAGKNDCATKSSSCAGTSKMDHQKDAFVVVPKGLCDK
                     LAGGS"
     CDS             6521..8695
                     /locus_tag="ctg1_543"
                     /transl_table=11
                     /translation="MIDPSLLLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIA
                     WLMSVEQASPFSIMSVTFTNKAAAEMRGRIDELMMGSSSGMWNGTFHGICHRILRAHYL
                     DAKLPEDFQIIDSDDQQRLLKRLIKAQNLDDKQWPARQVSWWINGKKDEGLRPAHIDAY
                     RDPVTQTYLQLYTAYQDACDRAGLVDFAEILLRALELLRDNKHIREHYQARFKHILVDE
                     FQDTNNIQYAWLRMMAGPQSHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLE
                     QNYRSTKTILEASNTLIANNTERMGKELWTDGNVGDPISVYSAYNELDEARFVVGKIKE
                     WQDKGGILNDCAILYRNNAQSRVLEEALLQTGLAYRIYGGMRFFERQEIKDALSYLRLM
                     NNRNDDTAFERVVNTPTRGLGDKTLDTVRFAARDRGCTLWQASVQLLEEKVLTGRAASA
                     LSRFVELINALEDDSAEMSLHSQTDHVIKTSGLFEMYQQEKGEKSKARIENLEELVTAT
                     RQFEKPEEADEMTMLTAFLTHAALEAGEGQADEFDDAVQLMTLHSAKGLEFPLVFMVGV
                     EEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIR
                     ELPESCLDEVRMKAQVSRPASSGRFSQSAVKENFNETGFTLGSRVLHPKFGEGTIINFE
                     GSGPQSRVQVAFNGEGIKWLVTAYAKLEKV"
     aSDomain        6539..8686
                     /aSDomain="TIGR01075"
                     /aSTool="tigrfam"
                     /description="uvrD: DNA helicase II"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_543_0014"
                     /evalue="0.00E+00"
                     /identifier="TIGR01075"
                     /label="ctg1_543"
                     /locus_tag="ctg1_543"
                     /protein_end="722"
                     /protein_start="6"
                     /score="1337.8"
                     /tool="antismash"
                     /translation="LLDGLNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVE
                     QASPFSIMSVTFTNKAAAEMRGRIDELMMGSSSGMWNGTFHGICHRILRAHYLDAKLPE
                     DFQIIDSDDQQRLLKRLIKAQNLDDKQWPARQVSWWINGKKDEGLRPAHIDAYRDPVTQ
                     TYLQLYTAYQDACDRAGLVDFAEILLRALELLRDNKHIREHYQARFKHILVDEFQDTNN
                     IQYAWLRMMAGPQSHVMIVGDDDQSIYGWRGAKVENIEKFTLEFPSVNTIRLEQNYRST
                     KTILEASNTLIANNTERMGKELWTDGNVGDPISVYSAYNELDEARFVVGKIKEWQDKGG
                     ILNDCAILYRNNAQSRVLEEALLQTGLAYRIYGGMRFFERQEIKDALSYLRLMNNRNDD
                     TAFERVVNTPTRGLGDKTLDTVRFAARDRGCTLWQASVQLLEEKVLTGRAASALSRFVE
                     LINALEDDSAEMSLHSQTDHVIKTSGLFEMYQQEKGEKSKARIENLEELVTATRQFEKP
                     EEADEMTMLTAFLTHAALEAGEGQADEFDDAVQLMTLHSAKGLEFPLVFMVGVEEGMFP
                     SQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAEMRRLYGQDKYHKPSRFIRELPESC
                     LDEVRMKAQVSRPASSGRFSQSAVKENFNETGFTLGSRVLHPKFGEGTIINFEGSGPQS
                     RVQVAFNGEGIKWLVTAYAKLE"
     PFAM_domain     6551..7336
                     /aSDomain="UvrD-helicase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00580.23"
                     /description="UvrD/REP helicase N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_543_0034"
                     /evalue="1.40E-74"
                     /label="ctg1_543"
                     /locus_tag="ctg1_543"
                     /protein_end="272"
                     /protein_start="10"
                     /score="251.6"
                     /tool="antismash"
                     /translation="LNDKQREAVAAPLENLLVLAGAGSGKTRVLVHRIAWLMSVEQASP
                     FSIMSVTFTNKAAAEMRGRIDELMMGSSSGMWNGTFHGICHRILRAHYLDAKLPEDFQI
                     IDSDDQQRLLKRLIKAQNLDDKQWPARQVSWWINGKKDEGLRPAHIDAYRDPVTQTYLQ
                     LYTAYQDACDRAGLVDFAEILLRALELLRDNKHIREHYQARFKHILVDEFQDTNNIQYA
                     WLRMMAGPQSHVMIVGDDDQSIYGWRGAKVENIEKFTLEF"
     PFAM_domain     7352..8371
                     /aSDomain="UvrD_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13361.8"
                     /description="UvrD-like helicase C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_543_0035"
                     /evalue="5.40E-82"
                     /label="ctg1_543"
                     /locus_tag="ctg1_543"
                     /protein_end="617"
                     /protein_start="277"
                     /score="276.1"
                     /tool="antismash"
                     /translation="IRLEQNYRSTKTILEASNTLIANNTERMGKELWTDGNVGDPISVY
                     SAYNELDEARFVVGKIKEWQDKGGILNDCAILYRNNAQSRVLEEALLQTGLAYRIYGGM
                     RFFERQEIKDALSYLRLMNNRNDDTAFERVVNTPTRGLGDKTLDTVRFAARDRGCTLWQ
                     ASVQLLEEKVLTGRAASALSRFVELINALEDDSAEMSLHSQTDHVIKTSGLFEMYQQEK
                     GEKSKARIENLEELVTATRQFEKPEEADEMTMLTAFLTHAALEAGEGQADEFDDAVQLM
                     TLHSAKGLEFPLVFMVGVEEGMFPSQMSAEEAGRLEEERRLCYVGMTRAMQKLYITYAE
                     "
ORIGIN
        1 ttggcgccgt acatggctgc acggttggct gaggcgatac cgccgctgcc gccaccgata
       61 cagatatagt caaaatgtgt tgccattact ttctccaatt tgggctcatc gcgaacaggt
      121 tcgcattcag cctctgttat gcatatatcc aacgacctaa tctaggttag ttgggggtgg
      181 attgccaaat tgcaatccca gtcgctgagt cttgttgagc ggtcgcgacc ttattcaggc
      241 acaatccagt ccactttata gtgaccggtg gccggcgcaa ttgcttcttt caggaacggc
      301 agaatgcttt gcatctggct ttccagtttc cacggcgggt tgatgacaat catgcccgag
      361 gcggtcatgc cgcgctcgtt ggtgtcgggg gacacgccga gttcaatttg taagattttg
      421 cgaatgccga ggccttgcaa accttcaatc atgtcctcga tgtcgcagcg gttcaccacc
      481 ggataccaga tggcgtaaat gccggtcgcc caacgcttgt agctttgcgc gatcgcctgc
      541 accacatcgc gatactcttt ggcgagctca tacggcgggt caatcagcac cagaccacgg
      601 cgctctttcg gcggcaggct ggctttcagg cgggcaaatc cgtcttcttt gaaaattgcc
      661 acttggcgat cgcggtgaaa ctcctgctcc agcagcgggt aatcgctcgg atgcagctcc
      721 gtcagcacca tgcggtcatg gctgcgcaga tgcgcgcgtg ccacacgcgg tgaacccggg
      781 tagtaacgca gctcgccatc gtcgttgagc gctttaatcg cctcgagata gctgtgaata
      841 tcttccggga cttcggtttg ttgccacagg cgggcgatac cttgtttgta ttcaccggtt
      901 ttttctgacc attcgtgggt cagatcgtag cggccgacac ccgagtgcgt gtcgtggtag
      961 acaaagggtt tgtctttctg ctgcagggca gacaggatca agctctgtac gatgtgtttc
     1021 accacatccg cgtggtttcc ggcatggaaa ctgtgtcggt aacttaacaa attgcgctct
     1081 ctcacccaaa gccgggtgct ggtcagttca aaaaacagtt cgcctgatta tacgccagta
     1141 ttgaaaattg ctgaacctga ctatatctat taacgtaata gccaaagtct tctttgctgg
     1201 cgcacaggtg tattgataac gtacgcttag caaatcatcg aatgaatgaa ggcgcttcgt
     1261 cgcgcccgtc tccatgactt caggtaccgt gatggttcgt cacggactct cttttatgaa
     1321 aaggaacgtt atatgtctaa tccacttctg acctttacgg atttgccacc gttttctgcg
     1381 attaagccag agcacgtcaa accagcggtt gagaaggcga ttgaagattg ccgcgcgcgc
     1441 attgatgcgg tgctggcagg caacgccgag ccaagctggg agagcgtgat tgcgccgatt
     1501 gaagaagtgg atgatcgctt aagccgtatc tggtcgccgg tcagccacat gaactccgtg
     1561 atgaacagcg atgagctgcg cgatgcctac gaaagctgcc tgccgatttt gtcggaatac
     1621 agcacctggg ttggccagca caaagggctg tttgacgcct acaaagcgat caaggccagt
     1681 aaagcattcg ccaccttgag ccgcgcgcag cagaaaacca tcaccgacgg tctgcgtgat
     1741 tttgagttgt cgggcatcgg tttgccagcg gctgagcaaa aacgctatgg cgaaatcagc
     1801 aaacgcatgt cggagctggg ctcgaaattc tccaacaacg tgcttgatgc caccatgggc
     1861 tggaccaagc aagtcacgga cgtgaacgaa ctgtcaggca tgccggaatc ggcgttggcg
     1921 gcggcgcaag cggcggcaga agccaaaggg ctggaaggct acttgctgac actcgatatt
     1981 ccgtcgtacc tgccggtgat gacctactgc gacaaccaag cgctgcgtca ggaactgtat
     2041 gaagcgtatg tgacccgcgc ctccgagcgc gggccgaatg ccggaaaatg ggacaacagc
     2101 gaaatcattg ctgagcagtt gaaactgcgt cacgaaatct cgcgcatgct tgggtttaac
     2161 acttacagtg aaaaatcact ggcgaccaaa atggccgagt cgccagagca ggtgctgagc
     2221 tttttgaatg atctggccac caaagccaag ccgcagggcg agcgcgaagt ggaagcgctg
     2281 cgccagttcg ccgagcaaga gtttggcgtc acaacgctta acctgtggga catcgcgtac
     2341 tacagcgaaa aacaaaagca gcatctgttt gaaatttccg acgaagagct gcgcccttac
     2401 ttcccagaac acaaagtggt gagcggcctg tttgaagtgc tccatcgcgt gtttgggatg
     2461 gacgtgaaag agcgtcaggg cgtggatact tggcacgaat cggtgcgttt tttcgatatt
     2521 ttcgacagcg aaggcgcgct gcgtggcagc ttctacctcg atttgtacgc ccgtgaacac
     2581 aaacgtggcg gcgcgtggat ggatgagtgc cgcgtgcgcc gcattaacgt agacggtgcg
     2641 ctgcaaacgc cggtcgccta cttgacctgt aacttcaacc gtccggtggg caacaaaccc
     2701 gcgctgttta cccatgatga agtggtcacg ctgttccatg aaactggcca cggtattcac
     2761 cacatgttga cgcaagttga ggtgggttcg gtgtctggta tcaacggtgt gccgtgggat
     2821 gcggtcgagc taccaagtca gttcctagaa aactggtgct gggaagaaga ggcgctggca
     2881 tttatctccg gtcactacga aaccggtgaa ccattgccga aagcgatgct ggaaaaaatg
     2941 ctggctgcga agaacttcca gtctgcgatg tttattctgc gccagttgga attcggtttg
     3001 ttcgatttca ctctgcacac cacgtacgat ccggaagctg gcccgaaagt gctggaaacg
     3061 ctcgccgacg tgaagaagaa agtggcggtg ctgccaagtt tggaatggaa ccgtttctcg
     3121 cacagtttca gccatatttt tgctggtggc tacagcgcgg gttactacag ctacttgtgg
     3181 gctgaagtgt tgtcggctga tgcgttttct cgattcgaag aagaggggat tttcaaccgc
     3241 gaaacgggtt tgagcttcct caatcacatt cttgaaatgg gcggcagcga agagccgatg
     3301 gagctgttca aacgcttccg tggtcgtgaa ccgcaaattg atgcgctgct gcgccacgca
     3361 ggcattgcgg cctaagcgac tgcattcgcg cgcttcattc aattcggttg gttaacccat
     3421 tcgtgcgctt aaccaatttg tgtgcttaac caaagtatga caataacccc gctccatgga
     3481 gcggggttat ttgttatggt aaagcccatg acggatgacg tcgttcacag gagatcgatc
     3541 atgaagggaa ttcaaagcgt gcgatggggt caagtgctct cgatgagtgc gttgctggcg
     3601 ttactgacat tgacggcggg ctgcgctgag atgagacaag caggcaccga cgtcggtcac
     3661 gccacccgcg acgcagcgac cgccattggt catgccacgc gcgacaccac caaagcgatt
     3721 gggcatgcga cgcgtgatgc ggttaactcg gtaaaagacg atctcaatgc tgcagaataa
     3781 cgcgctgcca cttgcggctc agccagtgat ccagcgacag acgacccggc ccccacacga
     3841 ccaccatcaa taacatgaat ccccacagct ggtggtcggt aaatccttgt tcccataaca
     3901 gcggatacga caccactgcc atcgcattga ccgcaaacag cgccagtgcg ctgaaccgtc
     3961 cgaaaagccc cggcatcaac aacagcggca gcgccagttc ggcgccggtt gccagatacg
     4021 cggcgagctg ccacggtagc agcggcacct gatattccag ttcaaacaag tacagcgtgc
     4081 tgtcccagtt ggcgatttta ctcaccccag attgccagaa cacccagccg gcccagatgc
     4141 ggcacagcag taaaagcaga ctggcgaagt cgcgttgcag ccagtggcac agggcatgat
     4201 aacggtgcat gaagtcagcc atgtcgggct ccttagttaa tcgtgagtat tgggggcggc
     4261 tacacgaaag ccagcgacaa tctccatcgc catgatggcg ggcaacgctg ccagtgcatc
     4321 cggatgaatc tgccccagtg gcgcgcgctg atgcatcgcc agcagcagtt gatacgtcgg
     4381 ctcatccagc gcttgcgtcc acggctcgcc ctcggccgtg caggtgatga tccccgactg
     4441 aagcgcattg atagtgagct ggctaaagtc gtcatcccgc atcgcacgct gcaaatcaaa
     4501 cagcgcaaac ggtgcgcaaa atggtgtggc ccacggcacc aactcaaaca ccagctgtgg
     4561 ctgctgttcc ggcgtgacct gactcagcgt gctgagtggc tgacagtcat tgcgcggtgc
     4621 ctgtgcgtat tgttgctgca cgtgatccag cgcccattca aaccgcgcta gtgctgcggc
     4681 atacggcgcg gcctgcatca cgggctgcgc gcgttcaatc accgccgcaa accctgcgcc
     4741 atagtggctg acatcaccgc gggtcagcgg atgcgacaac acgtattcgc gcgccagcgc
     4801 ggcaaaacac tcgtcgccca gcaccgccag cagcatcgga taggtggctt cgagcacttc
     4861 gcttaggctg atcacgcggt tgttgcgata aatctgcagc cgctcatcgg cgctcaagcc
     4921 gtccgcgata atcgcgcacg cgtcgccgcc cgcctgatag ttgaggccgc gggcaaactg
     4981 cgcctgcaat tgcgccagcg tcatgaggcg ctcctgatgc cgcgttcggc atcaatcgca
     5041 tgcaggcgtg cggccgcttg gtgcgcttcg cccagcagga cttcaggcgc tggaatctcc
     5101 agatcccact caatcagggt gcggcgcgtg ccgtgctgac ggcaccagcg ttcaaacagt
     5161 tgccacaccg cgtcgctgac cgggcggctg tgcgtatcaa tccagatgtc gccttgcggc
     5221 agcgttttga ctgcgtaacc cgcgagatga atttcggcca cggcactggc gggaatggca
     5281 tccagatacg tctggctgtc aaagccatgg ttaaacgccg acacatgcac gttgttgaga
     5341 tcgagcagca aacggcaatc ggtgcgctgc tgcaccgcgc gcaaaaattc ccactccgga
     5401 atggtggagt gggaaaaacg caggtagctg gacgggttct caatcagcag cggacgaccc
     5461 agtgcgtgtt gtacctgatc gacattgcgg cagaacaccg ccagcgcctc ttcggtgtag
     5521 ggcagtggta gcaggtcgtt aaaatagtgg ccgccgtttt cgctccagct gaggtgatcg
     5581 gaaatcagga tggggtcgat gtcatcgact aacgttttga gctgcgccag atgttgcgta
     5641 ttgaccgccg ccaccgaacc gagtgataag ccgatgccgt ggcaactgat gtcgtagcgc
     5701 tcacgcaggc ggcgcaaatc gcgcctggcc ggggcgtgcg gttgaaaata gttttcgctg
     5761 tgaatttcca gccagttcaa cggggtcggt tggctgagaa aatggctcat gtgagggctg
     5821 cgtaacccca cgccgaccag agggtgagag tgcgttgagt gcatggccat gtccttatcg
     5881 cggggtctgg gagagaaatc gagtgcgccg ccagcgccgc gcactcaagt cgtcgtgtgc
     5941 ggttacttcg ccatggtgct gccgccagcc agtttgtcgc acagcccttt ggggaccacg
     6001 acaaatgcat ctttctgatg atccattttt gacgtgccgg cgcaggagct ggatttggtc
     6061 gcgcagtcat ttttgcctgc tttcgccacg ccgtagcatt tttctttctc tgccgcggca
     6121 gctggcgctg cggttaatag agtgcccccc atggctagga ggccagtgat tgctgcggtg
     6181 acggctaggt ttgattgttt catctttatt tcctcgagac ggttccttgg tcgttagcgt
     6241 cgcaggccgt tgttgtggct tgcttaccca aaaaagagag gcaggcgcgc ggaaaacttt
     6301 caccacgcaa ataggaaaaa tcgagatatt gataaaataa ataactaaag cgatgattta
     6361 tcgagtgatt taatgtgtga ttttttttga gattttttgc acgccgcaac cgtttggggc
     6421 aaagcgcagg gaaattcaag gcaaatttcg ctcgcttggg tctcgctgcg tttaggggta
     6481 taatcgttca aattatgtat aaataaccag tagctaagcc atgatcgatc cctctctttt
     6541 acttgacggt ttaaacgaca aacaacgcga agcggtggcc gcaccgctag aaaacctgtt
     6601 ggtgctggca ggggccggta gtggcaaaac ccgggtgctg gtgcaccgca tcgcttggtt
     6661 gatgtcggtt gaacaggcct cgccgttctc catcatgtcc gtgaccttta ccaacaaagc
     6721 ggcggcggaa atgcgcggcc gtattgacga gctgatgatg ggcagttcat ctggaatgtg
     6781 gaacggcacg ttccatggca tctgccatcg cattctgcgc gcccattatc tcgacgccaa
     6841 actgccggaa gattttcaga tcatcgacag tgatgaccag cagcgtctgt tgaaacgcct
     6901 gatcaaagcg cagaatctgg atgataaaca gtggccagcg cgtcaggtgt cgtggtggat
     6961 taacggcaaa aaagacgaag gattgcgccc ggcgcacatc gacgcttatc gcgatccggt
     7021 gactcagacg tacctgcaac tttacaccgc gtatcaggat gcctgtgacc gcgcgggtct
     7081 ggtcgatttc gccgaaattc tgctgcgcgc gctcgagctg ctgcgcgaca acaaacacat
     7141 tcgcgaacat tatcaggcgc gctttaagca cattctggtc gacgaatttc aagacaccaa
     7201 caacattcaa tacgcgtggc tgcgcatgat ggcggggcca caatcgcacg tgatgatcgt
     7261 gggtgatgac gaccagtcaa tttacggctg gcgcggcgcg aaagtggaaa acatcgagaa
     7321 attcacactc gaatttccaa gcgtgaacac cattcgtctc gagcagaact accgctcgac
     7381 caaaaccatt cttgaagcgt ccaacaccct gatcgccaac aacaccgagc gtatgggcaa
     7441 agagctgtgg accgatggca acgtcggcga tccgatttcg gtctactcgg cgtacaacga
     7501 gctggatgaa gcgcgttttg tggtcggcaa aatcaaagag tggcaggaca aaggcggcat
     7561 tctcaatgac tgcgccattt tgtaccgcaa caacgcccag tcgcgggtgc tggaagaagc
     7621 cctgctgcaa accggattgg cgtaccgcat ttatggcggc atgcgcttct tcgaacgtca
     7681 ggaaatcaaa gatgcgctga gctatctgcg cctgatgaac aaccgcaatg acgacaccgc
     7741 ttttgagcgc gtggtcaaca cgcccacccg tggtctgggt gataaaacgc tggataccgt
     7801 gcgctttgcg gcgcgcgatc gcggctgcac gttgtggcaa gccagcgtgc agttactgga
     7861 agagaaagta ctcacgggcc gcgcggcctc ggcactgagc cgatttgttg aactgatcaa
     7921 cgcgctggaa gatgacagtg ccgagatgtc gctgcatagc caaaccgacc atgtgatcaa
     7981 aacctcgggc ctgtttgaga tgtaccagca ggaaaaaggc gagaaatcca aggcacgtat
     8041 tgagaacttg gaagagctgg tgaccgcaac gcgtcagttt gaaaaaccgg aagaagcgga
     8101 cgaaatgacc atgctgaccg cgttcttgac tcatgcggca ctggaagcgg gtgaaggaca
     8161 agcggatgaa ttcgacgatg ccgtgcaact gatgacgcta cacagtgcaa aaggtctgga
     8221 gtttccgctg gtatttatgg tcggcgtgga agagggcatg ttcccgagcc agatgtcggc
     8281 tgaagaagcg gggcgcctcg aagaggagcg ccgtctgtgc tacgtgggca tgacccgtgc
     8341 gatgcagaag ctctacatca cctacgcgga aatgcgccgc ctgtacggtc aggacaaata
     8401 ccacaagcca tcgcgcttta ttcgcgagtt accggaaagc tgccttgatg aagtgcgcat
     8461 gaaagcgcaa gtcagccgcc cggccagcag tggccgcttc agccagagcg cggtgaaaga
     8521 gaacttcaac gaaaccggct ttacccttgg gtcgcgtgtg ctgcatccga aatttggcga
     8581 aggcaccatc attaactttg aaggcagcgg tccgcaaagt cgcgtgcagg tcgcctttaa
     8641 cggcgagggc atcaagtggc tggtcacggc ttacgccaag ctggaaaaag tctaacccga
     8701 cggatgagcc acgaaaaacc cggtcagcgt accgggtttt ttatgtccgc cgccgacgga
     8761 ttttgagcgt cagaaaaaga aaaaccccga ggggccaaag cccttcgggg ttatagtctt
     8821 actcgcagca atccggctac taataggtgc tccctgcatc tattccttga taagtatgct
     8881 gtatccgtca gcgtaatccg ttcatcgcca tcctagcggt gtccttgatc atcctgatct
     8941 gctaactatc ctggttagct ctcatcactt ggtccttgag cggtgtcctt ggcatcatcc
     9001 tgatgctgag tccttgcctc gtccagagga gtccattgcc attcccttgt cgtcaccatc
     9061 ctagtcacga ttgagtccgt tcaatgtcct gtttgctatc cgtgccgatc attcatcctg
     9121 aataaccgta tcttcttcct gaagatcacc aatccgtagt gatttcctgt tccgtgtcag
     9181 catccttccg acacgattca tcttacggat ttcgtacttt ggagcaatgg taggaaatcg
     9241 tttgcttagc gatttatttt gcgctcacac gatggtttta tttaaaaaca atcacttagg
     9301 ttttacggtg tgccattttg ccagataaaa agcgagattg ccccattgct ttgtgcgaga
     9361 tctcttacac ggcgaggggc caatcgatga cacaaggatc actcgccgat cgcgacccct
     9421 tcacggcgag gatccgctgc gccttccaga ccttgcgccg tgatgcgaat cgcgtgcaag
     9481 ccggagttga gatcgcgcac ggcgactttc acgcccatct gctccagtgc tggtttgagc
     9541 tgttccgctt gggtgccctg ttcgacatcg gtttcaccaa aacggttgag cacatgcggc
     9601 tggtcaatcg cgcgctgaat gtccatgccc cattgcagat gggcaatcaa cgcctgcgcc
     9661 acatagccga tgatgcggct gccacccggt gaaccgatgg ctaagtaagg ttgctcgttg
     9721 tgtagcacaa tggtgggtgc catcgaagag cgcggccgct tgcccggctc cagacggttg
     9781 gcgattgggc ggccgttctc gtgggttgca aaggagaaat cggtcagttc gttgttgagc
     9841 aaaaagccgc gcacaaacag acgggagccg aatgcgtttt cgatcgtggt ggtcatcgac
     9901 accacattcc catcgcggtc gacgatgttg aaatggctgg tggacgacag ttcgatggac
     9961 tgatcggggc tttgcagcat cgcatgttgc caagggggcg tgccggcttc ggcgcgggtc
    10021 agcgctttac ccggctgaat cagcttggcg cgctgcgcca gatagccggg gtcgagcagt
    10081 ccttccgttg gcatcggcac ataatcctga tcggccatat acaagccgcg gtcggcaaac
    10141 gccaggcgtg aggcatcacc aatcacctgc cacgatttgg cgctgctggc gccccagcct
    10201 ttgaggtcat attgctcggt cagtgccaga atctggccga cggtcagtgc gccggagctt
    10261 ggcggcccca tgccacacac ctgatagctt tgatacggcg cgcacacggc tgcacgttgt
    10321 ttgatttgat aggcatcgaa atcatgctgc gccagcacac ccggattgcc catcgcggtc
    10381 tgaacggtgt ggacgatgtc ttcggcgatc tcgccctgat aaaacgcttt gtcaccgcgc
    10441 tgggcgatgg cgctcaacgt ggcggcgtac tcggggtttt tcagcatgct gcctgcggtc
    10501 agcggcgagc catcgggctg aaagaaatag gctttggtgg cgggaaaacg gctcaaccgc
    10561 tgctgatcgt cggcaatcag cgtggcaagg cgcgggctga cttcaaatcc ctcttgtgcc
    10621 tgtttgacca ctggctcaat caagcgcgcc caagccattt ttccgtacag acgatgcgtc
    10681 tcccacagca gtttgacggt gcccggcgtg ccgacggagc ggccaccgac cacggcatcg
    10741 taaaatttca gcggctggcc ggcgctgtcg agaaacagtt gcggcgtggc atcgagcggc
    10801 gcggtttcgc ggccatcaaa agtcgtgagc gccttttgtt tggcgtccca gtacaccaga
    10861 aagg
//
