GCF_001083805.1_ASM108380v1_genomic - 23 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JXSK01000001 (original name was: NZ_JXSK01000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	NRPS	82,181	125,226	turnerbactin	NRP	23%
Region 1.2	NRPS	144,648	233,262	viscosin	NRP	12%
Region 1.3	NRPS,T1PKS	567,311	624,629	yersiniabactin	NRP + Polyketide	5%
Region 1.4	transAT-PKS	661,170	719,565
Region 1.5	NRPS-like,resorcinol	756,695	820,358	indigoidine	NRP	80%
Region 1.6	ladderane	877,056	918,240
Region 1.7	NRPS,T1PKS	1,111,042	1,168,011	luminmycin A	NRP + Polyketide:Modular type I	100%

NZ_JXSK01000002 (original name was: NZ_JXSK01000002.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	NRPS	95,796	167,500	odilorhabdins	NRP	80%
Region 2.2	betalactone	265,413	290,913
Region 2.3	NRPS	467,898	511,224	netropsin	NRP	13%

NZ_JXSK01000003 (original name was: NZ_JXSK01000003.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	terpene	127,097	150,732	carotenoid	Terpene	66%
Region 3.2	NRPS-like	312,105	367,665

NZ_JXSK01000005 (original name was: NZ_JXSK01000005.1)

Region	Type	From	To
Region 5.1	RiPP-like	10,072	20,998
Region 5.2	PpyS-KS,NRPS	123,244	186,246
Region 5.3	CDPS	238,229	268,540

NZ_JXSK01000008 (original name was: NZ_JXSK01000008.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	NRPS	259,975	353,831	lokisin	NRP	14%

NZ_JXSK01000006 (original name was: NZ_JXSK01000006.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 7.1	NRPS	42,190	96,472	luminmide	NRP	100%
Region 7.2	NRPS	157,506	211,221	taxlllaid A	NRP	4%
Region 7.3	NRPS	247,979	297,899	bicornutin A1 / bicornutin A2	NRP	100%

NZ_JXSK01000007 (original name was: NZ_JXSK01000007.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 8.1	T3PKS	1	34,535
Region 8.2	T1PKS,NRPS-like,NRPS	73,126	148,627	xenocoumacin 1 / xenocoumacin II	NRP + Polyketide:Modular type I	78%

NZ_JXSK01000011 (original name was: NZ_JXSK01000011.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 10.1	thiopeptide	34,029	60,138	O-antigen	Saccharide	14%

NZ_JXSK01000012 (original name was: NZ_JXSK01000012.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 12.1	siderophore	21,436	45,909	putrebactin / avaroferrin	Other	100%

No secondary metabolite regions were found in these records:: NZ_JXSK01000004 (original name was: NZ_JXSK01000004.1); NZ_JXSK01000009 (original name was: NZ_JXSK01000009.1); NZ_JXSK01000010 (original name was: NZ_JXSK01000010.1); NZ_JXSK01000013 (original name was: NZ_JXSK01000013.1); NZ_JXSK01000014 (original name was: NZ_JXSK01000014.1); NZ_JXSK01000016 (original name was: NZ_JXSK01000016.1); NZ_JXSK01000015 (original name was: NZ_JXSK01000015.1)

Compact view

c00001_NZ_JXSK.. - Region 1 - NRPS

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Location: 82,181 - 125,226 nt. (total: 43,046 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001771.1	0.26	NRP	scleric acid	Streptomyces sclerotialus
BGC0001343.1	0.25	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.24	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001441.1	0.24	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000417.1	0.23	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001302.1	0.23	Other	lomofungin	Streptomyces lomondensis
BGC0001591.1	0.22	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.22	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001636.1	0.21	NRP	KK-1	Curvularia clavata
BGC0001211.1	0.21	NRP	albachelin	Amycolatopsis alba DSM 44262

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001771.1	0.60	NRP	scleric acid	Streptomyces sclerotialus
BGC0001343.1	0.59	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.57	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001441.1	0.57	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0000417.1	0.56	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001302.1	0.56	Other	lomofungin	Streptomyces lomondensis
BGC0001591.1	0.54	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.54	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001636.1	0.54	NRP	KK-1	Curvularia clavata
BGC0001211.1	0.53	NRP	albachelin	Amycolatopsis alba DSM 44262

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 82180 - 125226:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_91

Search NORINE for peptide: strict or relaxed

AMP-binding (461..856): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAEnIGSVvK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

ctg1_95

Search NORINE for peptide: strict or relaxed

AMP-binding (32..439): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPsQsiVcK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 60% (weak)

c00001_NZ_JXSK.. - Region 2 - NRPS

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Location: 144,648 - 233,262 nt. (total: 88,615 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.1	0.57	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000389.1	0.51	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001132.1	0.45	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.45	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1	0.44	NRP	ambactin	Xenorhabdus miraniensis
BGC0001135.1	0.43	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.1	0.42	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.39	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000438.1	0.39	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001833.1	0.39	NRP	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.1	0.82	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000389.1	0.79	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001132.1	0.76	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.75	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001131.1	0.75	NRP	ambactin	Xenorhabdus miraniensis
BGC0001135.1	0.74	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.1	0.74	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.71	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000438.1	0.71	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001833.1	0.71	NRP	icosalide A, icosalide B	Burkholderia gladioli

Similar known gene clusters

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 144647 - 233262:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (phe - thr) + (phe - val - X) + (val - thr - val - phe - val - thr - phe - val - val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_149

Search NORINE for peptide: strict or relaxed

AMP-binding (605..1000): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AMP-binding (1673..2024): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

ctg1_150

Search NORINE for peptide: strict or relaxed

AMP-binding (686..1081): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AMP-binding (1757..2154): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (2811..3206): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASfIAdVCK
Nearest Stachelhaus code:: bht
Stachelhaus code match:: 80% (moderate)

ctg1_151

Search NORINE for peptide: strict or relaxed

AMP-binding (846..1241): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (1917..2322): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (2998..3382): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (4039..4434): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AMP-binding (5110..5495): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (6157..6564): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (7240..7635): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AMP-binding (8292..8687): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (9363..9758): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

c00001_NZ_JXSK.. - Region 3 - NRPS,T1PKS

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Location: 567,311 - 624,629 nt. (total: 57,319 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.73	NRP	yersiniabactin	Yersinia enterocolitica
BGC0000373.1	0.52	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001444.1	0.52	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.52	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001560.1	0.50	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001831.1	0.48	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001161.1	0.48	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.48	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.48	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000449.1	0.48	NRP	tridecaptin	Paenibacillus terrae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000467.1	0.69	NRP	yersiniabactin	Yersinia enterocolitica
BGC0000373.1	0.60	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001444.1	0.60	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.60	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001560.1	0.59	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001831.1	0.57	Polyketide	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001161.1	0.57	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.57	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.57	Polyketide	1-heptadecene	Moorea producens JHB
BGC0000449.1	0.57	NRP	tridecaptin	Paenibacillus terrae

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 567310 - 624629:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys) + (ohmal - cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_468

CAL_domain (155..465): pk

minowa: NH2

Prediction, score:

NH2: 116.3
fatty_acid: 30.1
shikimic_acid: 0.0
AHBA: 0.0
Acetyl-CoA: -3.4

ctg1_475

Search NORINE for peptide: strict or relaxed

AMP-binding (35..431): dhb

NRPSPredictor2: dhb

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: tLPAQGVLCK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

ctg1_478

Search NORINE for peptide: strict or relaxed

PKS_AT (538..816): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 137.6
Methoxymalonyl-CoA: 65.1
Methylmalonyl-CoA: 58.2
inactive: 48.7
Isobutyryl-CoA: 42.1
Propionyl-CoA: 41.1
Benzoyl-CoA: 34.8
Acetyl-CoA: 33.0
2-Methylbutyryl-CoA: 32.4
CHC-CoA: 29.8
Ethylmalonyl-CoA: 28.8
fatty_acid: 26.9
3-Methylbutyryl-CoA: 26.1
trans-1,2-CPDA: 12.6

AMP-binding (3039..3440): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

ctg1_479

Search NORINE for peptide: strict or relaxed

AMP-binding (560..953): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNMSMIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

c00001_NZ_JXSK.. - Region 4 - transAT-PKS

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Location: 661,170 - 719,565 nt. (total: 58,396 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.33	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001104.1	0.28	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001264.1	0.23	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.23	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0000205.1	0.23	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0001244.1	0.22	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.22	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.22	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.22	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001998.1	0.22	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001104.1	0.61	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001264.1	0.57	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.57	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0000205.1	0.56	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0001244.1	0.55	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276.1	0.55	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.55	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.55	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001998.1	0.54	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4

Similar known gene clusters

No matches found.

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 661169 - 719565:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal)
Non-colinear ordering:: ctg1_537 + ctg1_548 + ctg1_542

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_542

PKS_AT (7..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 58.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.4
Methoxymalonyl-CoA: 56.1
inactive: 44.5
Methylmalonyl-CoA: 44.1
Propionyl-CoA: 26.9
2-Methylbutyryl-CoA: 15.5
fatty_acid: 14.4
Isobutyryl-CoA: 13.9
CHC-CoA: 11.7
Acetyl-CoA: 9.1
Ethylmalonyl-CoA: 8.6
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

c00001_NZ_JXSK.. - Region 5 - NRPS-like,resorcinol

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Location: 756,695 - 820,358 nt. (total: 63,664 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
resorcinol: DarB

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001131.1	0.34	NRP	ambactin	Xenorhabdus miraniensis
BGC0000876.1	0.32	Other	neopolyoxin C	Streptomyces tendae
BGC0000375.1	0.30	NRP	indigoidine	Streptomyces chromofuscus
BGC0000703.1	0.26	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001281.1	0.23	Polyketide	ustilagic acid	Ustilago maydis 521
BGC0000427.1	0.22	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000957.1	0.21	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13
BGC0000727.1	0.21	Saccharide	indigoidine	Streptomyces aureofaciens
BGC0000328.1	0.20	NRP	coronatine	Pseudomonas savastanoi pv. glycinea
BGC0001778.1	0.19	Other	showdomycin	Streptomyces showdoensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000957.1	0.57	NRP, Polyketide	mycotrienin I	Streptomyces sp. XZQH13
BGC0000427.1	0.55	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000328.1	0.52	NRP	coronatine	Pseudomonas savastanoi pv. glycinea
BGC0001465.1	0.51	Other	bromopyrroles/bromophenols	Marinomonas mediterranea MMB-1
BGC0001131.1	0.51	NRP	ambactin	Xenorhabdus miraniensis
BGC0001778.1	0.51	Other	showdomycin	Streptomyces showdoensis
BGC0001237.1	0.51	Polyketide	thiolactomycin	Salinispora pacifica DSM 45543 = CNS-863
BGC0001873.1	0.51	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001890.1	0.50	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0001479.1	0.50	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102

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Predicted core structure(s)

For candidate cluster 5, location 756694 - 820358:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gln)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 756694 - 799130:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_612

Search NORINE for peptide: strict or relaxed

AMP-binding (30..439): gln

NRPSPredictor2: gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWQFGLInK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 90% (moderate)

c00001_NZ_JXSK.. - Region 6 - ladderane

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Location: 877,056 - 918,240 nt. (total: 41,185 nt) Show pHMM detection rules used

ladderane: ladderane

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001075.1	0.17	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0000906.1	0.16	Other	heme D1	Heliophilum fasciatum
BGC0000719.1	0.16	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0001488.1	0.15	Other	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000928.1	0.14	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.14	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000905.1	0.14	Other	heme D1	Heliobacillus mobilis
BGC0001343.1	0.14	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001540.1	0.14	Other	CC-1065	Streptomyces zelensis
BGC0000887.1	0.14	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001075.1	0.48	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0000906.1	0.46	Other	heme D1	Heliophilum fasciatum
BGC0000719.1	0.46	Saccharide	tobramycin	Streptoalloteichus hindustanus
BGC0001488.1	0.45	Other	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000928.1	0.44	Other	T3 toxin	Cylindrospermopsis raciborskii T3
BGC0000188.1	0.44	Alkaloid	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000905.1	0.44	Other	heme D1	Heliobacillus mobilis
BGC0001343.1	0.44	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0001540.1	0.44	Other	CC-1065	Streptomyces zelensis
BGC0000887.1	0.44	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C

Similar known gene clusters

No matches found.

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c00001_NZ_JXSK.. - Region 7 - NRPS,T1PKS

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Location: 1,111,042 - 1,168,011 nt. (total: 56,970 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000383.1	1.43	NRP, Polyketide	luminmycin A	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000396.1	0.67	NRP	nodularin	Nostoc sp. 73.1
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001050.1	0.62	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001826.1	0.61	NRP	xeneprotides A-C	Xenorhabdus sp. KJ12.1
BGC0000457.1	0.61	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000389.1	0.59	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001185.1	0.57	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001825.1	0.54	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000436.1	0.54	NRP	syringolin A	Rhizobium sp. AP16

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000383.1	0.89	NRP, Polyketide	luminmycin A	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000396.1	0.67	NRP	nodularin	Nostoc sp. 73.1
BGC0001909.1	0.66	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001050.1	0.64	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001826.1	0.64	NRP	xeneprotides A-C	Xenorhabdus sp. KJ12.1
BGC0000457.1	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000389.1	0.63	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001185.1	0.62	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001825.1	0.61	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000436.1	0.61	NRP	syringolin A	Rhizobium sp. AP16

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Predicted core structure(s)

For candidate cluster 9, location 1111041 - 1168011:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (thr) + (orn - X - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_958

Search NORINE for peptide: strict or relaxed

AMP-binding (477..893): orn

NRPSPredictor2: orn

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DlGdVGSIDK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 80% (moderate)

AMP-binding (1550..1939): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGwItgIvK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 60% (weak)

PKS_AT (2673..2968): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 132.8
inactive: 80.9
Methoxymalonyl-CoA: 52.7
Methylmalonyl-CoA: 33.0
Propionyl-CoA: 27.8
2-Methylbutyryl-CoA: 16.2
Isobutyryl-CoA: 15.6
CHC-CoA: 15.2
fatty_acid: 11.0
Acetyl-CoA: 10.5
Ethylmalonyl-CoA: 10.4
Benzoyl-CoA: 9.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg1_960

Search NORINE for peptide: strict or relaxed

AMP-binding (464..878): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

c00002_NZ_JXSK.. - Region 1 - NRPS

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Location: 95,796 - 167,500 nt. (total: 71,705 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

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Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001716.1	0.46	NRP	odilorhabdins	Xenorhabdus nematophila AN6/1
BGC0000389.1	0.43	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001758.1	0.33	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000426.1	0.33	NRP	sevadicin	Paenibacillus larvae
BGC0001844.1	0.32	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.32	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001131.1	0.32	NRP	ambactin	Xenorhabdus miraniensis
BGC0000331.1	0.32	NRP	cyanopeptin	Planktothrix agardhii NIVA-CYA 116
BGC0000438.1	0.32	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001220.1	0.31	NRP	aculeacin A	Aspergillus japonicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001716.1	0.76	NRP	odilorhabdins	Xenorhabdus nematophila AN6/1
BGC0000389.1	0.74	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001758.1	0.66	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000426.1	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0001844.1	0.65	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001131.1	0.65	NRP	ambactin	Xenorhabdus miraniensis
BGC0000331.1	0.65	NRP	cyanopeptin	Planktothrix agardhii NIVA-CYA 116
BGC0000438.1	0.65	NRP	syringopeptin 25A	Pseudomonas syringae pv. syringae
BGC0001220.1	0.64	NRP	aculeacin A	Aspergillus japonicus

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NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 95795 - 167500:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - ala) + (gly - X - X) + (X) + (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_129

Search NORINE for peptide: strict or relaxed

AMP-binding (530..935): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiESIGtVlK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 70% (weak)

AMP-binding (1623..2031): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: orn, horn
Single AA prediction:: orn

Stachelhaus prediction details:

Stachelhaus sequence:: DigDLGiiDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 60% (weak)

AMP-binding (2687..3094): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiEsiGTiVK
Nearest Stachelhaus code:: lys-b
Stachelhaus code match:: 60% (weak)

ctg2_130

Search NORINE for peptide: strict or relaxed

AMP-binding (546..942): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSpLiAEVwK
Nearest Stachelhaus code:: his
Stachelhaus code match:: 70% (weak)

ctg2_131

Search NORINE for peptide: strict or relaxed

AMP-binding (540..948): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQiGMvWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 80% (moderate)

AMP-binding (1607..2005): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMENsGavNK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 70% (weak)

AMP-binding (2682..3088): X

NRPSPredictor2: pro, pip

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: pro, pip
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLeNvShVvK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 60% (weak)

ctg2_132

Search NORINE for peptide: strict or relaxed

AMP-binding (485..888): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DiESIGtVtK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 70% (weak)

AMP-binding (1571..1984): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWqMigdDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 60% (weak)

AMP-binding (2657..3064): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

ctg2_136

Search NORINE for peptide: strict or relaxed

AMP-binding (58..500): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: iVyFyanImK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 40% (weak)

c00002_NZ_JXSK.. - Region 2 - betalactone

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Location: 265,413 - 290,913 nt. (total: 25,501 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.20	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.15	Other	FR-900098	Streptomyces rubellomurinus
BGC0000375.1	0.15	NRP	indigoidine	Streptomyces chromofuscus
BGC0001441.1	0.14	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001128.1	0.14	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1	0.14	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000597.1	0.13	RiPP	SWA-2138	Streptomyces sp. e14
BGC0000892.1	0.13	Other	caryoynencin	Burkholderia gladioli BSR3
BGC0000308.1	0.13	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001150.1	0.13	Polyketide	pamamycin-607	Streptomyces alboniger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.52	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.46	Other	FR-900098	Streptomyces rubellomurinus
BGC0000375.1	0.45	NRP	indigoidine	Streptomyces chromofuscus
BGC0001441.1	0.44	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001128.1	0.43	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1	0.43	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0000597.1	0.42	RiPP	SWA-2138	Streptomyces sp. e14
BGC0000892.1	0.41	Other	caryoynencin	Burkholderia gladioli BSR3
BGC0000308.1	0.41	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001150.1	0.41	Polyketide	pamamycin-607	Streptomyces alboniger

Similar known gene clusters

No matches found.

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Detailed TIGRFAM domain annotation

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c00002_NZ_JXSK.. - Region 3 - NRPS

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Location: 467,898 - 511,224 nt. (total: 43,327 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457.1	0.29	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417.1	0.27	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000342.1	0.25	NRP	enniatin	Fusarium equiseti
BGC0001399.1	0.25	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001538.1	0.24	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001185.1	0.24	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001132.1	0.24	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001560.1	0.24	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001050.1	0.24	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001128.1	0.24	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457.1	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417.1	0.60	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000342.1	0.59	NRP	enniatin	Fusarium equiseti
BGC0001399.1	0.58	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001538.1	0.58	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001185.1	0.58	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001560.1	0.57	NRP, Polyketide	cryptomaldamide	Moorea producens JHB
BGC0001050.1	0.57	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001128.1	0.57	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 467897 - 511224:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_435

Search NORINE for peptide: strict or relaxed

AMP-binding (478..881): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DlWtVcMIyK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 60% (weak)

c00003_NZ_JXSK.. - Region 1 - terpene

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Location: 127,097 - 150,732 nt. (total: 23,636 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000656.1	0.52	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000647.1	0.48	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000640.1	0.35	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.1	0.32	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000639.1	0.30	Terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.1	0.30	Terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000638.1	0.30	Terpene	carotenoid	Pantoea ananatis
BGC0000642.1	0.27	Terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000646.1	0.26	Terpene	β-carotein	uncultured bacterium
BGC0000635.1	0.25	Terpene	carotenoid	Paracoccus sp. N81106

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000656.1	0.80	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000647.1	0.77	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000640.1	0.68	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000630.1	0.65	Terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000639.1	0.64	Terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.1	0.64	Terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000638.1	0.64	Terpene	carotenoid	Pantoea ananatis
BGC0000642.1	0.60	Terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000646.1	0.59	Terpene	β-carotein	uncultured bacterium
BGC0000635.1	0.58	Terpene	carotenoid	Paracoccus sp. N81106

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Detailed TIGRFAM domain annotation

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c00003_NZ_JXSK.. - Region 2 - NRPS-like

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Location: 312,105 - 367,665 nt. (total: 55,561 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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Detailed domain annotation

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.67	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000465.1	0.55	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000426.1	0.54	NRP	sevadicin	Paenibacillus larvae
BGC0001399.1	0.53	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001075.1	0.53	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0001050.1	0.51	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001806.1	0.51	NRP	tolaasin A	Pseudomonas tolaasii
BGC0000901.1	0.49	Other	ferrichrome	Aspergillus niger
BGC0000410.1	0.48	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001343.1	0.48	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000389.1	0.67	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000465.1	0.61	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001075.1	0.61	Terpene, Polyketide	aurachin RE	Rhodococcus erythropolis
BGC0000426.1	0.60	NRP	sevadicin	Paenibacillus larvae
BGC0001399.1	0.60	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0001050.1	0.59	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001806.1	0.59	NRP	tolaasin A	Pseudomonas tolaasii
BGC0001343.1	0.58	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.58	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000891.1	0.58	Other (Aminocoumarin)	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16

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No matches found.

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c00005_NZ_JXSK.. - Region 1 - RiPP-like

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Location: 10,072 - 20,998 nt. (total: 10,927 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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core biosynthetic genes

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001206.1	0.17	Other	indolmycin	Streptomyces griseus subsp. griseus
BGC0001285.1	0.06	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000273.1	0.05	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0001207.1	0.04	NRP	teixobactin	Eleftheria terrae
BGC0001060.1	0.04	Polyketide	dynemicin A	Micromonospora chersina
BGC0001603.1	0.04	Saccharide	gentamicin	Micromonospora echinospora
BGC0000689.1	0.03	Saccharide	2-deoxystreptamine	Micromonospora echinospora
BGC0000696.1	0.03	Saccharide	gentamicin	Micromonospora echinospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001206.1	0.48	Other	indolmycin	Streptomyces griseus subsp. griseus
BGC0001285.1	0.27	Other (Fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000273.1	0.22	Polyketide, Saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0001207.1	0.21	NRP	teixobactin	Eleftheria terrae
BGC0001060.1	0.20	Polyketide	dynemicin A	Micromonospora chersina
BGC0001603.1	0.19	Saccharide	gentamicin	Micromonospora echinospora
BGC0000689.1	0.17	Saccharide	2-deoxystreptamine	Micromonospora echinospora
BGC0000696.1	0.17	Saccharide	gentamicin	Micromonospora echinospora

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c00005_NZ_JXSK.. - Region 2 - NRPS,PpyS-KS

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Location: 123,244 - 186,246 nt. (total: 63,003 nt) Show pHMM detection rules used

PpyS-KS: PpyS
NRPS: cds(Condensation and (AMP-binding or A-OX))

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000426.1	0.41	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.39	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001833.1	0.35	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417.1	0.34	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000410.1	0.34	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001185.1	0.33	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000554.1	0.33	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000553.1	0.32	RiPP	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0001615.1	0.32	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000349.1	0.32	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000426.1	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0000389.1	0.71	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001833.1	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000417.1	0.67	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0001185.1	0.66	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000349.1	0.65	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001128.1	0.64	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.64	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.1	0.64	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 123243 - 186246:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly - val - D-phe) + (thr - val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 128232 - 186246:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly - val - D-phe) + (thr - val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg5_128

Search NORINE for peptide: strict or relaxed

AMP-binding (463..860): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQiGVIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 90% (moderate)

AMP-binding (1518..1910): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAYWlGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (2564..2958): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVAAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 100% (strong)

ctg5_129

Search NORINE for peptide: strict or relaxed

AMP-binding (467..881): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNVGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1543..1937): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFfGiTyK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 70% (weak)

c00005_NZ_JXSK.. - Region 3 - CDPS

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Location: 238,229 - 268,540 nt. (total: 30,312 nt) Show pHMM detection rules used

CDPS: (CDPS or cycdipepsynth)

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core biosynthetic genes

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000487.1	0.33	RiPP	carnocyclin	Carnobacterium maltaromaticum
BGC0000554.1	0.33	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.1	0.32	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001407.1	0.32	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001525.1	0.32	Other	bartoloside 2, bartoloside 3, bartoloside 4	Synechocystis salina LEGE 06155
BGC0001526.1	0.32	Other	bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K	Synechocystis salina LEGE 06099
BGC0001948.1	0.31	Other	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000504.1	0.31	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000513.1	0.31	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000521.1	0.31	RiPP	lacticin 481	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001948.1	0.65	Other	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0001986.1	0.61	Other	purincyclamide	Streptomyces chrestomyceticus
BGC0000678.1	0.50	Terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000488.1	0.47	RiPP	circularin A	Clostridium beijerinckii
BGC0000487.1	0.47	RiPP	carnocyclin	Carnobacterium maltaromaticum
BGC0000554.1	0.47	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.1	0.47	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001407.1	0.47	RiPP	bicereucin	Bacillus cereus SJ1
BGC0000541.1	0.47	RiPP	paenicidin A	Paenibacillus polymyxa
BGC0000517.1	0.47	RiPP	haloduracin β, haloduracin α	Bacillus halodurans C-125

Similar known gene clusters

No matches found.

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c00006_NZ_JXSK.. - Region 1 - NRPS

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Location: 259,975 - 353,831 nt. (total: 93,857 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Pfam domains

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Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.1	0.43	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.1	0.43	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001131.1	0.42	NRP	ambactin	Xenorhabdus miraniensis
BGC0001128.1	0.42	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.1	0.41	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.41	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.39	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833.1	0.36	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000389.1	0.35	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001312.1	0.33	NRP	viscosin	Pseudomonas fluorescens SBW25

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.1	0.74	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.1	0.74	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001131.1	0.73	NRP	ambactin	Xenorhabdus miraniensis
BGC0001128.1	0.73	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.1	0.73	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.73	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.71	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833.1	0.69	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0000389.1	0.68	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0001312.1	0.66	NRP	viscosin	Pseudomonas fluorescens SBW25

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 259974 - 353831:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - val - ala - ala - thr - thr - X - X - ala - val - thr) + (X - val - X - val - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg6_253

Search NORINE for peptide: strict or relaxed

AMP-binding (605..1004): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (1680..2079): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (2755..3146): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

AMP-binding (3803..4194): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

AMP-binding (4851..5256): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (5933..6338): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (7014..7415): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAESIGtViK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 80% (moderate)

AMP-binding (8072..8474): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVeSIGAVtK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 80% (moderate)

AMP-binding (9150..9541): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 100% (strong)

AMP-binding (10194..10593): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 100% (strong)

AMP-binding (11269..11674): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

ctg6_254

Search NORINE for peptide: strict or relaxed

AMP-binding (291..692): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DvESIGgVtK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 70% (weak)

AMP-binding (1364..1763): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGaTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (2439..2840): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVefIGAVtK
Nearest Stachelhaus code:: arg
Stachelhaus code match:: 70% (weak)

AMP-binding (3516..3915): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGaTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (4591..4992): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVsaCGcItK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 60% (weak)

c00007_NZ_JXSK.. - Region 1 - NRPS

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Location: 42,190 - 96,472 nt. (total: 54,283 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.1	0.60	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.49	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.1	0.40	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.36	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.1	0.34	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.33	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.32	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.1	0.31	NRP	AM-toxin	Alternaria alternata
BGC0001131.1	0.31	NRP	ambactin	Xenorhabdus miraniensis
BGC0001825.1	0.30	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.1	0.84	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1	0.78	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.1	0.72	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.1	0.68	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.1	0.67	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844.1	0.66	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641.1	0.66	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.1	0.65	NRP	AM-toxin	Alternaria alternata
BGC0001131.1	0.64	NRP	ambactin	Xenorhabdus miraniensis
BGC0001825.1	0.63	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 42189 - 96472:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - phe - X - phe - phe)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg7_63

Search NORINE for peptide: strict or relaxed

AMP-binding (64..464): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGaTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (1141..1540): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AMP-binding (2197..2597): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIAAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 90% (moderate)

AMP-binding (3273..3668): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

AMP-binding (4344..4739): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWcIgAVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 80% (moderate)

c00007_NZ_JXSK.. - Region 2 - NRPS

Download region GenBank file

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Location: 157,506 - 211,221 nt. (total: 53,716 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.1	0.44	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000389.1	0.38	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.33	NRP	sevadicin	Paenibacillus larvae
BGC0000457.1	0.32	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000913.1	0.30	Other	MK-8	Enterobacter cloacae
BGC0001833.1	0.30	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.29	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000396.1	0.29	NRP	nodularin	Nostoc sp. 73.1
BGC0001135.1	0.29	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000901.1	0.28	Other	ferrichrome	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.1	0.75	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000389.1	0.70	NRP	massetolide A	Pseudomonas fluorescens SS101
BGC0000426.1	0.66	NRP	sevadicin	Paenibacillus larvae
BGC0000457.1	0.65	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000913.1	0.63	Other	MK-8	Enterobacter cloacae
BGC0001833.1	0.63	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.1	0.63	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000396.1	0.62	NRP	nodularin	Nostoc sp. 73.1
BGC0001135.1	0.62	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000901.1	0.62	Other	ferrichrome	Aspergillus niger

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 157505 - 211221:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (thr - X - D-X) + (D-tyr - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg7_126

Search NORINE for peptide: strict or relaxed

AMP-binding (549..957): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

AMP-binding (2046..2454): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DGfAVASVCK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 90% (moderate)

ctg7_127

Search NORINE for peptide: strict or relaxed

AMP-binding (466..888): thr

NRPSPredictor2: thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: thr
Single AA prediction:: thr

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 100% (strong)

AMP-binding (1531..1939): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DGfAVASVCK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 90% (moderate)

AMP-binding (2582..2990): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DGfAVASVCK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 90% (moderate)

c00007_NZ_JXSK.. - Region 3 - NRPS

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Location: 247,979 - 297,899 nt. (total: 49,921 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.1	0.38	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.36	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.36	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001615.1	0.33	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000348.1	0.31	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001641.1	0.30	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.30	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001185.1	0.29	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.29	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.29	NRP	ambactin	Xenorhabdus miraniensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.1	0.71	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.69	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.69	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001615.1	0.66	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0000348.1	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001641.1	0.64	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.64	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001185.1	0.63	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0001833.1	0.62	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131.1	0.62	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 247978 - 297899:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg7_186

Search NORINE for peptide: strict or relaxed

AMP-binding (23..440): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: hcwcIGVgpK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 40% (weak)

ctg7_199

Search NORINE for peptide: strict or relaxed

AMP-binding (287..688): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DvESmGgVtK
Nearest Stachelhaus code:: lys
Stachelhaus code match:: 60% (weak)

AMP-binding (1364..1765): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVeSIGAVtK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 80% (moderate)

AMP-binding (2441..2842): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVeSIGAVtK
Nearest Stachelhaus code:: trp
Stachelhaus code match:: 80% (moderate)

c00008_NZ_JXSK.. - Region 1 - T3PKS

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Location: 1 - 34,535 nt. (total: 34,535 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

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Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000887.1	0.21	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C
BGC0000554.1	0.16	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000205.1	0.16	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000521.1	0.16	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626.1	0.15	RiPP	thuricin	Bacillus thuringiensis
BGC0000504.1	0.15	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000698.1	0.14	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0000286.1	0.13	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000795.1	0.13	Saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000928.1	0.13	Other	T3 toxin	Cylindrospermopsis raciborskii T3

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000887.1	0.53	Alkaloid	saxitoxin, gonyautoxin 2, gonyautoxin 3, toxin C2, toxin C3, gonyautoxin 5, decarbamoylsaxitoxin, decarbamoylgonyautoxin 2, decarbamoylgonyautoxin 3	Dolichospermum circinale AWQC131C
BGC0000554.1	0.46	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000205.1	0.46	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000521.1	0.46	RiPP	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626.1	0.45	RiPP	thuricin	Bacillus thuringiensis
BGC0000504.1	0.45	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000698.1	0.42	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0000286.1	0.42	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000795.1	0.41	Saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000928.1	0.41	Other	T3 toxin	Cylindrospermopsis raciborskii T3

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

c00008_NZ_JXSK.. - Region 2 - NRPS,NRPS-like,T1PKS

Download region GenBank file

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Location: 73,126 - 148,627 nt. (total: 75,502 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

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regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

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NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000979.1	1.05	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	1.05	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000427.1	1.00	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001050.1	0.98	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000375.1	0.98	NRP	indigoidine	Streptomyces chromofuscus
BGC0000900.1	0.96	Other	ferrichrome	Aspergillus oryzae
BGC0001909.1	0.92	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001249.1	0.92	NRP	dimethylcoprogen	Alternaria alternata
BGC0001187.1	0.89	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0000293.1	0.84	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000979.1	0.69	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.69	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000427.1	0.67	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0001050.1	0.66	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000375.1	0.66	NRP	indigoidine	Streptomyces chromofuscus
BGC0000900.1	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001909.1	0.64	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001249.1	0.64	NRP	dimethylcoprogen	Alternaria alternata
BGC0001187.1	0.63	NRP, Polyketide	xenolozoyenone	Glarea lozoyensis
BGC0000876.1	0.62	Other	neopolyoxin C	Streptomyces tendae

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 73125 - 148627:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - mal) + (D-asn) + (ohmal) + (asn) + (glu) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg8_102

PKS_AT (533..819): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.0
inactive: 64.2
Methoxymalonyl-CoA: 37.6
Methylmalonyl-CoA: 32.3
Propionyl-CoA: 20.9
2-Methylbutyryl-CoA: 18.2
CHC-CoA: 12.5
Isobutyryl-CoA: 9.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg8_103

Search NORINE for peptide: strict or relaxed

AMP-binding (241..641): glu

NRPSPredictor2: glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: glu, gln
Single AA prediction:: glu

Stachelhaus prediction details:

Stachelhaus sequence:: DAQDmGaVqK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 70% (weak)

ctg8_105

Search NORINE for peptide: strict or relaxed

AMP-binding (458..838): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

ctg8_108

PKS_AT (526..808): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 93.0
inactive: 57.4
Methoxymalonyl-CoA: 51.6
Methylmalonyl-CoA: 37.9
Propionyl-CoA: 22.4
Acetyl-CoA: 13.5
Isobutyryl-CoA: 10.0
fatty_acid: 9.7
Ethylmalonyl-CoA: 9.0
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg8_109

Search NORINE for peptide: strict or relaxed

AMP-binding (457..853): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKIGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

ctg8_112

PKS_AT (1104..1400): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 135.5
inactive: 100.4
Methoxymalonyl-CoA: 53.6
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 19.7
fatty_acid: 16.9
Isobutyryl-CoA: 14.6
Ethylmalonyl-CoA: 13.9
2-Methylbutyryl-CoA: 12.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2603..2894): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 126.2
inactive: 71.6
Methoxymalonyl-CoA: 35.5
Methylmalonyl-CoA: 29.7
Isobutyryl-CoA: 18.8
fatty_acid: 17.3
Acetyl-CoA: 14.4
Benzoyl-CoA: 11.2
Propionyl-CoA: 11.1
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

c00010_NZ_JXSK.. - Region 1 - thiopeptide

Download region GenBank file

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Location: 34,029 - 60,138 nt. (total: 26,110 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.25	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001579.1	0.16	RiPP	duramycin	Streptomyces cinnamoneus
BGC0001514.1	0.16	Other	aristeromycin	Streptomyces citricolor
BGC0000563.1	0.16	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000804.1	0.16	Saccharide	acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03	Streptomyces coelicoflavus ZG0656
BGC0000781.1	0.16	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000601.1	0.16	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0001743.1	0.16	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0001222.1	0.16	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.16	RiPP	gassericin A	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000784.1	0.58	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0001579.1	0.47	RiPP	duramycin	Streptomyces cinnamoneus
BGC0001514.1	0.47	Other	aristeromycin	Streptomyces citricolor
BGC0000563.1	0.47	RiPP	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000804.1	0.47	Saccharide	acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03	Streptomyces coelicoflavus ZG0656
BGC0000781.1	0.47	Saccharide	O-antigen	Pseudomonas aeruginosa
BGC0000601.1	0.46	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0001743.1	0.46	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0001222.1	0.46	RiPP	acidocin B	Lactobacillus acidophilus
BGC0000491.1	0.46	RiPP	gassericin A	Lactobacillus gasseri

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Thiopeptides

Core peptide predictions

No core peptides found.

c00012_NZ_JXSK.. - Region 1 - siderophore

Download region GenBank file

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Location: 21,436 - 45,909 nt. (total: 24,474 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001870.1	0.59	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001572.1	0.43	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.33	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.30	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1	0.29	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.1	0.29	Other	desferrioxamine	Streptomyces argillaceus
BGC0000942.1	0.25	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001713.1	0.25	Other	ochrobactin	Ochrobactrum anthropi
BGC0001531.1	0.24	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.1	0.23	NRP	acinetoferrin	Acinetobacter haemolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001870.1	0.84	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0001572.1	0.74	Other	desferrioxamine E	Pantoea agglomerans
BGC0001478.1	0.66	Other	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.1	0.64	Other	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1	0.62	Other	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.1	0.62	Other	desferrioxamine	Streptomyces argillaceus
BGC0000942.1	0.59	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001713.1	0.58	Other	ochrobactin	Ochrobactrum anthropi
BGC0001531.1	0.57	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.1	0.57	NRP	acinetoferrin	Acinetobacter haemolyticus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names