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Overview
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1.10
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1.13
1.14

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LT907842.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NAGGN | 156,005 | 170,862 |
Region 2 | NRPS | 208,135 | 259,597 | pyoverdin | NRP | 9%
Region 3 | siderophore | 349,280 | 361,205 |
Region 4 | redox-cofactor | 1,549,767 | 1,571,914 | lankacidin C | NRP + Polyketide | 13%
Region 5 | RiPP-like | 2,087,249 | 2,096,526 |
Region 6 | NRPS-like | 2,288,238 | 2,317,494 | ambactin | NRP | 25%
Region 7 | arylpolyene | 2,677,089 | 2,720,664 | APE Vf | Other | 45%
Region 8 | RiPP-like | 3,812,929 | 3,823,807 |
Region 9 | NRPS | 4,859,475 | 4,921,220 | viscosin | NRP | 68%
Region 10 | NRPS-like | 5,660,158 | 5,701,185 |
Region 11 | thiopeptide | 5,735,877 | 5,765,125 | pseudopyronine A / pseudopyronine B | Other:Fatty acid | 12%
Region 12 | NRPS | 5,913,902 | 5,979,533 | pyoverdin | NRP | 11%
Region 13 | betalactone | 6,289,200 | 6,312,353 | fengycin | NRP | 13%
Region 14 | NRPS | 6,415,945 | 6,462,214 | tolaasin I / tolaasin F | NRP:Lipopeptide | 70%

NZ_LT907842.1 - Region 1 - NAGGN
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 156,005 - 170,862 nt. (total: 14,858 nt) Show pHMM detection rules used
NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAGGN | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.22 | Other | tabtoxin | Pseudomonas syringae
BGC0000885.1 |  | 0.17 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000888.1 |  | 0.16 | Other | bacilysin | Bacillus sp. CS93
BGC0000937.1 |  | 0.15 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001184.1 |  | 0.15 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001374.1 |  | 0.14 | Other | thienodolin | Streptomyces albogriseolus
BGC0000207.1 |  | 0.14 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0000451.1 |  | 0.14 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0001928.1 |  | 0.14 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001739.1 |  | 0.13 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.55 | Other | tabtoxin | Pseudomonas syringae
BGC0000885.1 |  | 0.49 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000888.1 |  | 0.46 | Other | bacilysin | Bacillus sp. CS93
BGC0000937.1 |  | 0.45 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001184.1 |  | 0.44 | Other | bacilysin | Bacillus velezensis FZB42
BGC0001374.1 |  | 0.44 | Other | thienodolin | Streptomyces albogriseolus
BGC0000207.1 |  | 0.43 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0000451.1 |  | 0.43 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0001928.1 |  | 0.43 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001739.1 |  | 0.42 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 2 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 208,135 - 259,597 nt. (total: 51,463 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000457.1 |  | 0.32 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001479.1 |  | 0.29 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001833.1 |  | 0.28 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001671.1 |  | 0.28 | NRP | monobactam | Agrobacterium tumefaciens
BGC0001825.1 |  | 0.27 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0000313.1 |  | 0.27 | NRP | beauvericin | Beauveria bassiana
BGC0001132.1 |  | 0.26 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.1 |  | 0.26 | NRP | enniatin | Fusarium equiseti
BGC0001135.1 |  | 0.26 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000855.1 |  | 0.26 | Other | ectoine | Methylomicrobium kenyense

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000457.1 |  | 0.65 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001479.1 |  | 0.63 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001833.1 |  | 0.62 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001671.1 |  | 0.62 | NRP | monobactam | Agrobacterium tumefaciens
BGC0001825.1 |  | 0.61 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0000313.1 |  | 0.60 | NRP | beauvericin | Beauveria bassiana
BGC0001132.1 |  | 0.60 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.1 |  | 0.60 | NRP | enniatin | Fusarium equiseti
BGC0001135.1 |  | 0.59 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000855.1 |  | 0.59 | Other | ectoine | Methylomicrobium kenyense

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 208134 - 259597:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - D-X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_210: pk - glu - X - X
  Search NORINE for peptide: strict or relaxed
  CAL_domain (40..476): pk
  minowa: NH2
  Prediction, score:
    NH2: 162.6
    Acetyl-CoA: 47.3
    fatty_acid: 16.2
    AHBA: 11.4
    shikimic_acid: -2.9
  AMP-binding (1128..1520): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFGRINK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2173..2577): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAegiGAVMK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3695..4094): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWeLtadDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      50% (weak)

NZ_LT907842.1 - Region 3 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 349,280 - 361,205 nt. (total: 11,926 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001453.1 |  | 0.24 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.24 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001713.1 |  | 0.18 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000295.1 |  | 0.18 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001499.1 |  | 0.18 | Other | aerobactin | Pantoea ananatis
BGC0000944.1 |  | 0.18 | Other (Non-NRP siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001498.1 |  | 0.17 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001408.1 |  | 0.15 | Other | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000772.1 |  | 0.14 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0000939.1 |  | 0.14 | Other | aerobactin | Grimontia hollisae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001453.1 |  | 0.58 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  | 0.58 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001713.1 |  | 0.50 | Other | ochrobactin | Ochrobactrum anthropi
BGC0000295.1 |  | 0.50 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0001499.1 |  | 0.50 | Other | aerobactin | Pantoea ananatis
BGC0000944.1 |  | 0.49 | Other (Non-NRP siderophore) | staphyloferrin A | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001498.1 |  | 0.48 | Other | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001408.1 |  | 0.46 | Other | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000772.1 |  | 0.43 | Saccharide | lipopolysaccharide | Brucella melitensis
BGC0000939.1 |  | 0.43 | Other | aerobactin | Grimontia hollisae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 4 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,549,767 - 1,571,914 nt. (total: 22,148 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000860.1 |  | 0.24 | Other | ectoine | Methylarcula marina
BGC0000259.1 |  | 0.22 | Polyketide | prodigiosin | Serratia marcescens
BGC0000260.1 |  | 0.20 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0000723.1 |  | 0.16 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0001917.1 |  | 0.15 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001586.1 |  | 0.15 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0000919.1 |  | 0.15 | Other | phaseolotoxin | Pseudomonas syringae
BGC0001440.1 |  | 0.15 | Other | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0000874.1 |  | 0.14 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0000895.1 |  | 0.14 | Other | citrulline | Lactobacillus plantarum subsp. plantarum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000860.1 |  | 0.57 | Other | ectoine | Methylarcula marina
BGC0000259.1 |  | 0.55 | Polyketide | prodigiosin | Serratia marcescens
BGC0000260.1 |  | 0.52 | Polyketide | prodigiosin | Hahella chejuensis KCTC 2396
BGC0000723.1 |  | 0.46 | Saccharide | β-D-galactosylvalidoxylamine-A | Streptomyces hygroscopicus subsp. limoneus
BGC0001917.1 |  | 0.46 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001586.1 |  | 0.45 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0000919.1 |  | 0.44 | Other | phaseolotoxin | Pseudomonas syringae
BGC0001440.1 |  | 0.44 | Other | cystargolide A, cystargolide B | Kitasatospora cystarginea
BGC0000874.1 |  | 0.44 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0000895.1 |  | 0.43 | Other | citrulline | Lactobacillus plantarum subsp. plantarum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 5 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,087,249 - 2,096,526 nt. (total: 9,278 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000870.1 |  | 0.14 | Other | mycolic acid | Mycobacterium tuberculosis H37Rv
BGC0001483.1 |  | 0.06 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0000877.1 |  | 0.04 | Other | polyoxin A, polyoxin H | Streptomyces cacaoi subsp. asoensis
BGC0000058.1 |  | 0.04 | Polyketide | FD-891 | Streptomyces graminofaciens
BGC0001212.1 |  | 0.04 | NRP, Polyketide | nannocystin a | Nannocystis sp. MB1016
BGC0001205.1 |  | 0.03 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum
BGC0001110.1 |  | 0.03 | NRP, Polyketide | psymberin, irciniastatin B | uncultured bacterium psy1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000870.1 |  | 0.44 | Other | mycolic acid | Mycobacterium tuberculosis H37Rv
BGC0001483.1 |  | 0.24 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0000877.1 |  | 0.20 | Other | polyoxin A, polyoxin H | Streptomyces cacaoi subsp. asoensis
BGC0000058.1 |  | 0.19 | Polyketide | FD-891 | Streptomyces graminofaciens
BGC0001212.1 |  | 0.18 | NRP, Polyketide | nannocystin a | Nannocystis sp. MB1016
BGC0001205.1 |  | 0.16 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum
BGC0001110.1 |  | 0.16 | NRP, Polyketide | psymberin, irciniastatin B | uncultured bacterium psy1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 6 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,288,238 - 2,317,494 nt. (total: 29,257 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.32 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.29 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.25 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.24 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001778.1 |  | 0.23 | Other | showdomycin | Streptomyces showdoensis
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001641.1 |  | 0.18 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.18 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000334.1 |  | 0.18 | NRP | cyclosporine | Tolypocladium inflatum NRRL8044
BGC0001758.1 |  | 0.18 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001168.1 |  | 0.65 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001900.1 |  | 0.63 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001516.1 |  | 0.59 | NRP | aspergillic acid | Aspergillus flavus NRRL3357
BGC0001599.1 |  | 0.57 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001778.1 |  | 0.56 | Other | showdomycin | Streptomyces showdoensis
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001641.1 |  | 0.50 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.50 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000334.1 |  | 0.50 | NRP | cyclosporine | Tolypocladium inflatum NRRL8044
BGC0001758.1 |  | 0.50 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 2288237 - 2317494:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2114: leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (176..561): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DsiFlGLVlK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)

NZ_LT907842.1 - Region 7 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,677,089 - 2,720,664 nt. (total: 43,576 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001366.1 |  | 0.25 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0001723.1 |  | 0.24 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0000889.1 |  | 0.24 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000234.1 |  | 0.23 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.23 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001897.1 |  | 0.22 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0002029.1 |  | 0.22 | Other | bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C | Streptomyces lunaelactis
BGC0001592.1 |  | 0.22 | Other | ferroverdin | Streptomyces lunaelactis
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001366.1 |  | 0.58 | Polyketide | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0001723.1 |  | 0.58 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.57 | Polyketide | griseusin | Streptomyces griseus
BGC0000889.1 |  | 0.57 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000234.1 |  | 0.56 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.56 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001897.1 |  | 0.55 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0002029.1 |  | 0.55 | Other | bagremycin A, bagremycin B, bagremycin C, bagremycin E, bagremycin F, bagremycin G, ferroverdin A, ferroverdin B, ferroverdin C | Streptomyces lunaelactis
BGC0001592.1 |  | 0.55 | Other | ferroverdin | Streptomyces lunaelactis
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 8 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,812,929 - 3,823,807 nt. (total: 10,879 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.1 |  | 0.06 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000382.1 |  | 0.06 | NRP | lipstatin | Streptomyces toxytricini
BGC0001751.1 |  | 0.03 | NRP, Polyketide | pyxipyrrolone A, pyxipyrrolone B | Pyxidicoccus sp. MCy9557

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.1 |  | 0.27 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000382.1 |  | 0.26 | NRP | lipstatin | Streptomyces toxytricini
BGC0001751.1 |  | 0.16 | NRP, Polyketide | pyxipyrrolone A, pyxipyrrolone B | Pyxidicoccus sp. MCy9557

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 9 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,859,475 - 4,921,220 nt. (total: 61,746 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.64 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000463.1 |  | 0.47 | NRP | xantholysin A, xantholysin B, xantholysin C | Pseudomonas putida
BGC0001312.1 |  | 0.45 | NRP | viscosin | Pseudomonas fluorescens SBW25
BGC0000435.1 |  | 0.43 | NRP | syringafactin | Pseudomonas syringae pv. tomato str. DC3000
BGC0000323.1 |  | 0.43 | NRP | cichofactin A, cichofactin B | Pseudomonas cichorii
BGC0001758.1 |  | 0.38 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.37 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.36 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001838.1 |  | 0.35 | NRP | WLIP | Pseudomonas putida
BGC0001135.1 |  | 0.35 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.86 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000463.1 |  | 0.77 | NRP | xantholysin A, xantholysin B, xantholysin C | Pseudomonas putida
BGC0001312.1 |  | 0.75 | NRP | viscosin | Pseudomonas fluorescens SBW25
BGC0000435.1 |  | 0.74 | NRP | syringafactin | Pseudomonas syringae pv. tomato str. DC3000
BGC0000323.1 |  | 0.74 | NRP | cichofactin A, cichofactin B | Pseudomonas cichorii
BGC0001758.1 |  | 0.71 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.70 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001844.1 |  | 0.69 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001838.1 |  | 0.68 | NRP | WLIP | Pseudomonas putida
BGC0001135.1 |  | 0.68 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 4859474 - 4921220:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (thr - val - leu - ser) + (leu - ser - ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_4462: thr - val - leu - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (552..948): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1624..2001): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALWIGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2680..3065): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3735..4130): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHMSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg1_4463: leu - ser - ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (568..953): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1606..1997): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHMSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2636..3027): ile
  NRPSPredictor2: ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      ile
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAMFLGCTYK
    Nearest Stachelhaus code:
      ile
    Stachelhaus code match:
      100% (strong)

NZ_LT907842.1 - Region 10 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,660,158 - 5,701,185 nt. (total: 41,028 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000893.1 |  | 0.31 | NRP | chloramphenicol | Streptomyces venezuelae ATCC 10712
BGC0000343.1 |  | 0.27 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001488.1 |  | 0.23 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000410.1 |  | 0.23 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001964.1 |  | 0.21 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001168.1 |  | 0.21 | NRP | livipeptin | Streptomyces lividans 1326
BGC0000375.1 |  | 0.20 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001940.1 |  | 0.20 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000928.1 |  | 0.19 | Other | T3 toxin | Cylindrospermopsis raciborskii T3

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000893.1 |  | 0.65 | NRP | chloramphenicol | Streptomyces venezuelae ATCC 10712
BGC0000343.1 |  | 0.61 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001488.1 |  | 0.56 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000410.1 |  | 0.56 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001964.1 |  | 0.54 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001168.1 |  | 0.53 | NRP | livipeptin | Streptomyces lividans 1326
BGC0000375.1 |  | 0.53 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001940.1 |  | 0.52 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000928.1 |  | 0.51 | Other | T3 toxin | Cylindrospermopsis raciborskii T3

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 5660157 - 5701185:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_5128: glu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (26..423): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DSWdLGtigK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      60% (weak)

NZ_LT907842.1 - Region 11 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,735,877 - 5,765,125 nt. (total: 29,249 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.23 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000886.1 |  | 0.22 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0001964.1 |  | 0.19 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000722.1 |  | 0.18 | Other (Cyclitol), Polyketide | validamycin A | Streptomyces hygroscopicus subsp. jinggangensis
BGC0001285.1 |  | 0.18 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001625.1 |  | 0.16 | Polyketide | isofuranonaphthoquinone | Streptomyces sp. CB01883
BGC0001386.1 |  | 0.16 | Polyketide | JBIR-76, JBIR-77 | Streptomyces sp. RI-77
BGC0000219.1 |  | 0.16 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001783.1 |  | 0.15 | Other | streptonigrin | Streptomyces flocculus
BGC0000815.1 |  | 0.15 | Alkaloid | loline | Epichloe uncinata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000783.1 |  | 0.56 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0000886.1 |  | 0.55 | Other | allylmalonyl-CoA | Streptomyces tsukubensis
BGC0001964.1 |  | 0.51 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000722.1 |  | 0.50 | Other (Cyclitol), Polyketide | validamycin A | Streptomyces hygroscopicus subsp. jinggangensis
BGC0001285.1 |  | 0.50 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001625.1 |  | 0.47 | Polyketide | isofuranonaphthoquinone | Streptomyces sp. CB01883
BGC0001386.1 |  | 0.47 | Polyketide | JBIR-76, JBIR-77 | Streptomyces sp. RI-77
BGC0000219.1 |  | 0.46 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0001783.1 |  | 0.45 | Other | streptonigrin | Streptomyces flocculus
BGC0000815.1 |  | 0.44 | Alkaloid | loline | Epichloe uncinata

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_LT907842.1 - Region 12 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,913,902 - 5,979,533 nt. (total: 65,632 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.41 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001615.1 |  | 0.34 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001833.1 |  | 0.33 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.33 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001844.1 |  | 0.32 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.32 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001135.1 |  | 0.31 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.1 |  | 0.31 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.1 |  | 0.31 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.1 |  | 0.31 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.73 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001615.1 |  | 0.68 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001833.1 |  | 0.66 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001844.1 |  | 0.66 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.65 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001135.1 |  | 0.65 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.1 |  | 0.65 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.1 |  | 0.64 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.1 |  | 0.64 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 5913901 - 5979533:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-ser - X - gly - X) + (X - D-X - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_5351: X - X - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (508..916): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGedhGtVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1573..1973): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgeVcGgVtK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
  AMP-binding (3092..3490): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg1_5352: ser - X - gly - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (517..914): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1991..2397): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGedhGtVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (3042..3433): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4083..4483): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgeVcGgVtK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)

NZ_LT907842.1 - Region 13 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,289,200 - 6,312,353 nt. (total: 23,154 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.20 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001465.1 |  | 0.20 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0000891.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000890.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000312.1 |  | 0.20 | NRP | bassianolide | Beauveria bassiana
BGC0001458.1 |  | 0.15 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0000131.1 |  | 0.15 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001140.1 |  | 0.15 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001983.1 |  | 0.15 | Other | triacsins | Kitasatospora aureofaciens
BGC0000632.1 |  | 0.14 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.53 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001465.1 |  | 0.52 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0000891.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000890.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000312.1 |  | 0.52 | NRP | bassianolide | Beauveria bassiana
BGC0001458.1 |  | 0.45 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0000131.1 |  | 0.45 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001140.1 |  | 0.45 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001983.1 |  | 0.44 | Other | triacsins | Kitasatospora aureofaciens
BGC0000632.1 |  | 0.44 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LT907842.1 - Region 14 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,415,945 - 6,462,214 nt. (total: 46,270 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000457.1 |  | 0.33 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001444.1 |  | 0.30 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.30 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001132.1 |  | 0.30 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.29 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000410.1 |  | 0.29 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001135.1 |  | 0.28 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.28 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001767.1 |  | 0.27 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001261.1 |  | 0.27 | NRP | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000457.1 |  | 0.66 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001444.1 |  | 0.64 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.64 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001132.1 |  | 0.63 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.63 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000410.1 |  | 0.63 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001135.1 |  | 0.61 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.61 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001767.1 |  | 0.61 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001261.1 |  | 0.61 | NRP | AM-toxin | Alternaria alternata

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 6415944 - 6462214:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (leu - asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_5818: leu - asp
  Search NORINE for peptide: strict or relaxed
  AMP-binding (466..849): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1498..1898): asp
  NRPSPredictor2: asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asp
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgWKLGVVDK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      90% (moderate)