LOCUS       NZ_CP040938.1          11687 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP040938.1 Dolosigranulum pigrum strain KPL1914 chromosome.
ACCESSION   NZ_CP040938
VERSION     NZ_CP040938.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:04:54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 166954
            Orig. end    :: 178641
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..765)
                     /locus_tag="ctg1_191"
                     /transl_table=11
                     /translation="MSKLNQVVFHNTLRKKEVWVYLAFTLLPLLVFVTELTDTKFLRLT
                     GDFSEMNFLDFYGTTLGIIDGMILPAIVIAYIASTMFYGEINKGILFLYKDINRKKVMN
                     SKVLSLMKTYGLYLLLVMLSSLVVYYFFVIQMKGGTFSLLGSVTPVTYYSVLGVLGLFG
                     INIVAILVAANLSVRFSTGVTVLGTIFFLFLMQAISRVDGLNYLSPMSYRELFNVGQMT
                     FSMSFILLVFLCVVYVVSAYTLLYRQFSKVEY"
     protocluster    1..11687
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[171797:173951](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4844..6997)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..11687
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11687
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(758..1645)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 167.5; E-value:
                     6.6e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_192"
                     /transl_table=11
                     /translation="MLDVSNVSKQYSGNDFYSLKDVSFTIEKGEIVGLIGKNGAGKTTL
                     LKLLAKSHFPTTGVIRYRGLDIFSEDNVLRPFGLMIETVYYSHLTVKQNIEFYLDIHDQ
                     SEYKKNIQSVLETVELWHKKDFKPDGFSFGMKQRLSLAMSLVTNPEFMILDEPFVGLDP
                     DGVNDLMRILKQWAADRGTSIIVSSHQLNELEAICDRYLYIEGGALKKQFGKAAVEVTV
                     IELVDALQDRDALFSAYEAIQAISEDGKQIEVDSNSEAFHQILGTITASHNIKKIFTKE
                     NALNQYFKGSRDYE"
     PFAM_domain     complement(1172..1591)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_192_0001"
                     /evalue="1.50E-27"
                     /label="ctg1_192"
                     /locus_tag="ctg1_192"
                     /protein_end="158"
                     /protein_start="18"
                     /score="96.9"
                     /tool="antismash"
                     /translation="LKDVSFTIEKGEIVGLIGKNGAGKTTLLKLLAKSHFPTTGVIRYR
                     GLDIFSEDNVLRPFGLMIETVYYSHLTVKQNIEFYLDIHDQSEYKKNIQSVLETVELWH
                     KKDFKPDGFSFGMKQRLSLAMSLVTNPEFMILDEPF"
     CDS             complement(1629..2048)
                     /locus_tag="ctg1_193"
                     /transl_table=11
                     /translation="MYRKILLSLISTLIIFGTGIYLNVSMSLLMFAVISYVLPLMGNIV
                     IDYYVQTENVLIGSGIISTITTTGYAIFAILMENNINFDGFIRQHTYRSGNMTMGLEPG
                     LADMSQLIFVFALNLSVLYFIQYLSRGDFSHVRRK"
     CDS             2696..4006
                     /locus_tag="ctg1_194"
                     /transl_table=11
                     /translation="MFVNPIILFIYEILLDVALFFTTFNFLFTQNKPVLKRIFVSISVP
                     VVWIFSMIIHDLFYATDIVALLYGLVLYGIFFSLKRINFEVLNSILLLVYTKGIVEFLV
                     ALPINTLKYYNLHNHILVMITTKILTFIMSIAIYKKIYPYFTSNIDQVKAKKIVTYSLL
                     ILNILFSSYFIFIQWFDLYHKLLYFTLTITIIFVIITVGFLYALHKYLQLKFQHELSNQ
                     HLEALTKYNHIVEEETYKTKEFQHDYKNLMLSTTSFIENNDLAGLKEMMHSLIDYSKDY
                     FSHSTFQYKDIHNIKHPALKSIILAKLVTFTELGITCQFECRKPLDNIYIDTFDFIRVV
                     GILLDNAQEYVTTIEEKHIEILITSHTKMMELVISNPYIPDHYTLRNFKQEGFSLKGND
                     RGMGLSTITKIEKKHDNLTVLFEKNTIFSAKIITTKL"
     PFAM_domain     3689..3991
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_194_0002"
                     /evalue="2.10E-13"
                     /label="ctg1_194"
                     /locus_tag="ctg1_194"
                     /protein_end="432"
                     /protein_start="331"
                     /score="50.1"
                     /tool="antismash"
                     /translation="DTFDFIRVVGILLDNAQEYVTTIEEKHIEILITSHTKMMELVISN
                     PYIPDHYTLRNFKQEGFSLKGNDRGMGLSTITKIEKKHDNLTVLFEKNTIFSAKII"
     CDS             4024..4779
                     /locus_tag="ctg1_195"
                     /transl_table=11
                     /translation="MYPLIICEDSIGQLNAIKQIINLYTGFYESRFNVSLITSSPHEVL
                     DYLETYQPKKGVFLLDVHLNSTIDGLDLAEAIRKNDVNAKIVFITTDEHAAPLTFKRNL
                     EAMSFIEKPSNVEELRKNIFETLNIAYNRLTTSLDEKKQLFTFSRYGETVNIDFEKVLY
                     LQTSIEESHKLTLTTTLGEYEFSGSLIKCEENFPELFRISKSALINPGNVVSINYKNRD
                     IVLKNNHIIQYAFRRAKSIKEKFSNPNKN"
     PFAM_domain     4036..4392
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_195_0003"
                     /evalue="4.40E-14"
                     /label="ctg1_195"
                     /locus_tag="ctg1_195"
                     /protein_end="123"
                     /protein_start="4"
                     /score="52.7"
                     /tool="antismash"
                     /translation="IICEDSIGQLNAIKQIINLYTGFYESRFNVSLITSSPHEVLDYLE
                     TYQPKKGVFLLDVHLNSTIDGLDLAEAIRKNDVNAKIVFITTDEHAAPLTFKRNLEAMS
                     FIEKPSNVEELRKNI"
     PFAM_domain     4477..4758
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_195_0004"
                     /evalue="3.40E-14"
                     /label="ctg1_195"
                     /locus_tag="ctg1_195"
                     /protein_end="245"
                     /protein_start="151"
                     /score="53.0"
                     /tool="antismash"
                     /translation="ETVNIDFEKVLYLQTSIEESHKLTLTTTLGEYEFSGSLIKCEENF
                     PELFRISKSALINPGNVVSINYKNRDIVLKNNHIIQYAFRRAKSIKEKF"
     CDS             complement(4844..6997)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 282.2; E-value:
                     1.4e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_196"
                     /sec_met_domain="TIGR01193 (E-value: 9.7e-234, bitscore:
                     774.6, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.8e-37, bitscore:
                     124.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTNFRVIYQQDNMDCGTACVQMILHHYNSEFSIHKLKDLTDKGK
                     QGTSALGIKRCLESLNFDCLVIDADNAVWTDSAMTYPAIAHLNVHNGKHYVVVYGYQDN
                     KLFIADPDDGKYNMSIETFSAVWSRTLFVPSPGRHYKPIKEKVQGLMSFVPKIIQYKKF
                     VVFSIIASLLIMGLSIGSSYYFQGIIDSIIPANNISMLNIISFGLMISYVLRVIFGYIR
                     NYLLFILGQKLSRDIILNYFKHVLKLPISFFASRQSGEIISRFLDASTIIDALANTSLT
                     LLLDSIMVVVVGIVLLLQHNVLFGVTLVTLPLYIGTIILFIIKLDKSNEEEMESAAVLN
                     SSIIESLNGIETIKSYNSEKVIYQRVVGEFEDLMIKTLTTMTLDNMQGAIKTGTQLVGN
                     ALVLWLGAYYVMSGEMSIGALITYNALLVFFTEPLESVINLQVQIQKAQVASRRMNDIL
                     SIEVEGNISNDTVEIEEMGEADLKFDDVYFSYGLGELILRGITCEIKVGDKIALVGESG
                     SGKSTLAKMLVRFYDPSMGNIYFGKYDINTIDVHILRHNIVYVPQDSFFLAGTIRDNLL
                     FGLDYEPTQNQIEQACEIACIKSFIESLPLQYHTIVEEAGSNLSKGQKQRLAIVRALLT
                     NSQVIIFDEATSGIDVFSEQRIMDNIIKMTERTIIFITHSLPAAKLCEKIMVMDQGDLV
                     EEGIHEVLRYAGGTYQKLWEVIS"
     aSDomain        complement(4859..6970)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_196_0001"
                     /evalue="2.50E-233"
                     /identifier="TIGR01193"
                     /label="ctg1_196"
                     /locus_tag="ctg1_196"
                     /protein_end="713"
                     /protein_start="9"
                     /score="774.6"
                     /tool="antismash"
                     /translation="QQDNMDCGTACVQMILHHYNSEFSIHKLKDLTDKGKQGTSALGIK
                     RCLESLNFDCLVIDADNAVWTDSAMTYPAIAHLNVHNGKHYVVVYGYQDNKLFIADPDD
                     GKYNMSIETFSAVWSRTLFVPSPGRHYKPIKEKVQGLMSFVPKIIQYKKFVVFSIIASL
                     LIMGLSIGSSYYFQGIIDSIIPANNISMLNIISFGLMISYVLRVIFGYIRNYLLFILGQ
                     KLSRDIILNYFKHVLKLPISFFASRQSGEIISRFLDASTIIDALANTSLTLLLDSIMVV
                     VVGIVLLLQHNVLFGVTLVTLPLYIGTIILFIIKLDKSNEEEMESAAVLNSSIIESLNG
                     IETIKSYNSEKVIYQRVVGEFEDLMIKTLTTMTLDNMQGAIKTGTQLVGNALVLWLGAY
                     YVMSGEMSIGALITYNALLVFFTEPLESVINLQVQIQKAQVASRRMNDILSIEVEGNIS
                     NDTVEIEEMGEADLKFDDVYFSYGLGELILRGITCEIKVGDKIALVGESGSGKSTLAKM
                     LVRFYDPSMGNIYFGKYDINTIDVHILRHNIVYVPQDSFFLAGTIRDNLLFGLDYEPTQ
                     NQIEQACEIACIKSFIESLPLQYHTIVEEAGSNLSKGQKQRLAIVRALLTNSQVIIFDE
                     ATSGIDVFSEQRIMDNIIKMTERTIIFITHSLPAAKLCEKIMVMDQGDLVEEGIHEVLR
                     YAGGTYQKLW"
     PFAM_domain     complement(5057..5509)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_196_0007"
                     /evalue="1.10E-31"
                     /label="ctg1_196"
                     /locus_tag="ctg1_196"
                     /protein_end="647"
                     /protein_start="496"
                     /score="110.3"
                     /tool="antismash"
                     /translation="LRGITCEIKVGDKIALVGESGSGKSTLAKMLVRFYDPSMGNIYFG
                     KYDINTIDVHILRHNIVYVPQDSFFLAGTIRDNLLFGLDYEPTQNQIEQACEIACIKSF
                     IESLPLQYHTIVEEAGSNLSKGQKQRLAIVRALLTNSQVIIFDEATS"
     PFAM_domain     complement(5696..6505)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_196_0006"
                     /evalue="5.80E-51"
                     /label="ctg1_196"
                     /locus_tag="ctg1_196"
                     /protein_end="434"
                     /protein_start="164"
                     /score="173.9"
                     /tool="antismash"
                     /translation="VFSIIASLLIMGLSIGSSYYFQGIIDSIIPANNISMLNIISFGLM
                     ISYVLRVIFGYIRNYLLFILGQKLSRDIILNYFKHVLKLPISFFASRQSGEIISRFLDA
                     STIIDALANTSLTLLLDSIMVVVVGIVLLLQHNVLFGVTLVTLPLYIGTIILFIIKLDK
                     SNEEEMESAAVLNSSIIESLNGIETIKSYNSEKVIYQRVVGEFEDLMIKTLTTMTLDNM
                     QGAIKTGTQLVGNALVLWLGAYYVMSGEMSIGALITYNALLVFFTEPL"
     PFAM_domain     complement(6590..6985)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_196_0005"
                     /evalue="3.00E-36"
                     /label="ctg1_196"
                     /locus_tag="ctg1_196"
                     /protein_end="136"
                     /protein_start="4"
                     /score="124.2"
                     /tool="antismash"
                     /translation="FRVIYQQDNMDCGTACVQMILHHYNSEFSIHKLKDLTDKGKQGTS
                     ALGIKRCLESLNFDCLVIDADNAVWTDSAMTYPAIAHLNVHNGKHYVVVYGYQDNKLFI
                     ADPDDGKYNMSIETFSAVWSRTLFVPSP"
     CDS             complement(7297..7650)
                     /locus_tag="ctg1_197"
                     /transl_table=11
                     /translation="MHTRFKEGLKSFIISYVAMILYHLPSAYNPLFDIVHMMVIVGTLL
                     YGGYYFYRNGASSNGMAGLLIQVSLFTIGFNIALPLTREIFSARIMFMTGCSLSLIFLK
                     HIENNLYRIDRKS"
     CDS             complement(7819..8319)
                     /locus_tag="ctg1_198"
                     /transl_table=11
                     /translation="MNRALENMGFNKTQKNSNRLHSKENFKDWRNREVAELERLMGERR
                     IERKQVGTHSYLNHREYKEMKREIDTQKDKAQEFMQIRDELEVRLNKKTKEVNKKEKKS
                     TELSSENMELKNKNDTLTQRLNQLNWYVEEQEGKKNSFQRHGPADSAGLGFKGRNEPLK
                     VVG"
     CDS             complement(8480..8680)
                     /locus_tag="ctg1_199"
                     /transl_table=11
                     /translation="MSKKKNILLQIILSLSIISLVIDLFVNENKSHIFVMIASILISLV
                     ITQLYLERKEMDRIKEESKEE"
     CDS             complement(8794..8964)
                     /locus_tag="ctg1_200"
                     /transl_table=11
                     /translation="MHTLLRRFIPKGSDISQWSLNEIKEIENTINDYPRLLFDGLSANE
                     KFEAFQEAIAS"
     CDS             complement(8904..9902)
                     /locus_tag="ctg1_201"
                     /transl_table=11
                     /translation="MTQVKCTKLKPKGKHLDEDDREYLEKMARQNRQLPKHKRLTQADM
                     ADELGVHPSIISRELRRGQVTQKDPLWREYTIYSASAVQEKIDKGKTNKGPDPEFSPGD
                     SVLKAIETIIISQKYSPYAALQHLKKGDKFTHDQLPCLRTIYHYINADKFEKLTQDHLP
                     REGKTQRRTYHHVKKRKKVVPPNRLIKYRSESINNREEEGHWEMDCVESGKGHSKTCLL
                     TLVERKTRKSIIRKMTSQTQAQVLKQLDELEDSLGTERFKQQFKSITVDNGSEFLDYKS
                     LEGTVKSRENKRTHLFYCVSPTVLMSEDQMNRCTHFFGDLFPRGVTLVNGA"
     PFAM_domain     complement(9714..9869)
                     /aSDomain="HTH_38"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13936.8"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_201_0008"
                     /evalue="9.50E-07"
                     /label="ctg1_201"
                     /locus_tag="ctg1_201"
                     /protein_end="63"
                     /protein_start="11"
                     /score="28.6"
                     /tool="antismash"
                     /translation="KGKHLDEDDREYLEKMARQNRQLPKHKRLTQADMADELGVHPSII
                     SRELRRG"
     CDS             11121..11687
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 119.7;
                     E-value: 2.2e-36)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_202"
                     /sec_met_domain="Mac (E-value: 3.3e-12, bitscore: 43.2,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKHEYNKMIRGELYDPRDPYLRDLMTKQHALMDAFNESDRTDHA
                     TQNKLLEELLGQYHGESSHIRRPFFIDYGLNITIGKHFFANYNCTMLDVAPITIGKNIM
                     FGPNVSLNTPEHPLSAAERNMGLEFAQPITIEDNVWIGASVTVIGGVTIGQGAVIAAGA
                     VVTKDVPANTVVGGIPARVLKTIEN"
     PFAM_domain     11142..11291
                     /aSDomain="Mac"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12464.10"
                     /description="Maltose acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_202_0009"
                     /evalue="2.00E-11"
                     /label="ctg1_202"
                     /locus_tag="ctg1_202"
                     /protein_end="57"
                     /protein_start="7"
                     /score="44.0"
                     /tool="antismash"
                     /translation="KMIRGELYDPRDPYLRDLMTKQHALMDAFNESDRTDHATQNKLLE
                     ELLGQ"
     PFAM_domain     11514..11621
                     /aSDomain="Hexapep_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14602.8"
                     /description="Hexapeptide repeat of succinyl-transferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_202_0010"
                     /evalue="2.00E-10"
                     /label="ctg1_202"
                     /locus_tag="ctg1_202"
                     /protein_end="167"
                     /protein_start="131"
                     /score="40.3"
                     /tool="antismash"
                     /translation="PITIEDNVWIGASVTVIGGVTIGQGAVIAAGAVVTK"
ORIGIN
        1 ttaatactcc accttgctaa attgccggta caacaaggta tacgcactca cgacatacac
       61 cacacacaag aaaactagca gtataaaact catactaaac gtcatctgtc cgacattaaa
      121 tagctcgcga taactcattg gcgataagta attcaagcca tcgactcggc taatagcttg
      181 catgaggaac aggaagaaaa tagtccccaa cactgtgaca cctgttgaga atcgtacaga
      241 taaattagct gctaccaata tcgccacaat gtttatcccg aacagcccta acacgcctaa
      301 cacgctataa tacgtcacag gtgttacact acctagaagc gaaaaggtac cacctttcat
      361 ctggataacg aagaagtagt aaaccactaa cgatgagagc atgaccaaca atagatacaa
      421 cccatacgtt ttcatcagcg agagcacctt tgaattcata actttttttc gattaatatc
      481 tttgtataaa aataaaatcc ccttgttaat ttcgccgtag aacatcgtag aggcaatata
      541 ggcaatgacg atagccggca gaatcatgcc atcaataatc cctagcgtcg ttccataaaa
      601 atcaagaaag ttcatctccg aaaaatcgcc cgttaagcgc aagaatttcg tgtccgttaa
      661 ttccgtcaca aaaacaagga gtggcagaag ggtaaatgct agatataccc atacttcttt
      721 tttgcgcaat gtattgtgaa atacaacttg gttaagttta ctcatagtct ctgctccctt
      781 tgaaatattg atttaatgca ttttctttgg tgaaaatctt tttgatatta tggctagctg
      841 taatagtacc caaaatttgg tggaaggctt cactatttga atcgacttca atttgtttgc
      901 catcttctga gatggcctga atagcttcat atgcactgaa taacgcgtct ctgtcttgca
      961 gtgcatcgac caattcaatc acagtgactt caacagctgc tttgccaaat tgtttcttaa
     1021 gtgcaccacc ttcaatgtac aaataacgat cacaaatggc ttctaattca ttcaattgat
     1081 gacttgagac aataattgat gtgccacgat ctgcagccca ctgcttcaaa atacgcatca
     1141 gatcattcac gccatctgga tccaatccta caaatggttc atctaaaatc ataaattcag
     1201 gattcgtcac taaactcatt gccagtgaca agcgctgttt catcccaaaa gagaacccat
     1261 ctggcttaaa atctttcttg tgccataact caactgtttc cagtacggac tgaatatttt
     1321 tcttatattc tgattgatcg tgaatatcta agtaaaattc tatattttgt ttcactgtta
     1381 aatgactgta ataaaccgtc tcaatcatca acccaaatgg acgcaagaca ttatcttctg
     1441 agaatatatc cagccctcta tatcgaataa ctccagtcgt tgggaagtga gacttcgcta
     1501 acaacttcag taacgtcgtc ttccctgcgc cattcttccc gattaaacca acaatttctc
     1561 ctttttctat cgtaaaactg acatccttta gtgaataaaa atcattacca ctatattgct
     1621 tgcttacatt acttacgtct aacatgcgaa aaatctcctc tacttaaata ttgaataaaa
     1681 tataatacgg atagattcaa tgcgaaaaca aaaattaatt gactcatatc tgctaatccc
     1741 ggttcaagtc ccattgtcat attcccgcta cgatatgtgt gctgtctaat aaatccatca
     1801 aaattgatat tattttccat cagtatcgca aaaatagcat aacctgtcgt ggtaatcgta
     1861 gaaatgatac cacttcctat taatacattc tctgtttgta cataataatc aattactata
     1921 ttgcccatta acggtaatac atatgatatt acagcaaaca tcaaaagaga cattgataca
     1981 tttaaataaa tccctgtacc aaaaattatc aatgtactaa taagtgacaa taatattttt
     2041 ctatacattt tacttactcc ttatacaaat ttcccaatta acatattatg taaccaatga
     2101 atagcaatac aatcttgtaa tccatacttt tcatatacat aatacaacag catgcttatc
     2161 ggaaatttag tcactaagtt aaataacaaa ttactacttc acattttttc cgttataaac
     2221 taagtggaat ctacccaaat taatctgatt acaactaaat aattttctta atgttttaag
     2281 cattttcttc cctcccttcc gtctataatt tataatacct ttcttgtgtt agttagaaag
     2341 aattttttcc tattcgttat cttttggctc ctaaacgtaa tatctgtcaa gcaccctaac
     2401 ggttagaagc attattacta cgtttacaat gactaaatta ccgtaaccac aatgaatatt
     2461 aatctatata taattattat ttggaggaga ttttaatgac aaatctaatt agaaaaagga
     2521 cattaaggta cttaaggaac gttaattaca taaaatttac ggtgattata gtaataaaac
     2581 aaatacacat cgtgctatat ttaactgttt actgtcaaaa cataaaagat gctagacata
     2641 aatattaata acatgataaa atacccttat atagataatt tataagggtg tttttatgtt
     2701 tgttaatcca atcattctat ttatttatga aatattgctt gacgtagctt tgttcttcac
     2761 tacgttcaat tttttattca ctcaaaataa acctgtctta aagagaattt ttgtaagtat
     2821 atcagttccc gttgtttgga ttttttctat gattatacat gatctttttt atgccactga
     2881 tattgtggct ttactatatg gtttagtgtt gtatggcata tttttttcgt tgaaaagaat
     2941 aaatttcgaa gtacttaatt caattcttct actcgtttat actaaaggaa ttgtagaatt
     3001 cttggttgct ctccccatca acaccctaaa atattacaat ttacataacc acatattagt
     3061 catgattact acaaagatac taacgtttat tatgtcaatt gctatttata aaaaaatcta
     3121 cccatatttt acatccaata ttgaccaagt taaggcaaaa aaaatagtaa catactcact
     3181 attaatcctc aatattttat tctcatcata ttttatcttt attcaatggt ttgatttgta
     3241 tcataaactt ctttatttta cacttaccat aactatcata tttgtaatca ttactgtagg
     3301 ttttttatat gctttacaca aatatttaca attaaaattc caacacgaac tatccaatca
     3361 acatttagaa gcactcacta aatataatca tattgtcgaa gaagaaacct ataaaactaa
     3421 agaatttcaa cacgactata aaaatttaat gctatccacc accagtttta ttgaaaacaa
     3481 tgacttagct ggtctgaaag aaatgatgca ttcattaatc gattattcca aagactattt
     3541 cagtcactca acatttcaat ataaagatat tcataatatc aaacatcctg ctctaaagag
     3601 tattattcta gctaaattag ttacctttac cgaattggga attacctgtc aatttgaatg
     3661 tcgtaagcca ctagataata tatatataga tacatttgat ttcattcgtg tggtcggtat
     3721 cctattagat aatgcacaag aatacgttac gacaattgaa gaaaaacata ttgaaatatt
     3781 gattactagc cacaccaaaa tgatggaact tgttatttct aatccctaca tacctgatca
     3841 ttacaccctc cgtaatttta aacaagaagg attttctctg aaagggaatg atcgcggaat
     3901 gggattatca acaataacta aaattgagaa aaaacatgat aatctcacag tgttattcga
     3961 aaagaacacc attttttctg caaaaattat tactaccaaa ttataattga aaggattcag
     4021 ccaatgtatc cactcattat ttgcgaagac tcaatcggtc aattaaacgc aattaaacaa
     4081 attattaacc tttatacagg cttttatgaa tctcgtttta atgtgtcatt aataacatct
     4141 tctccacacg aagttttaga ttatttagaa acgtatcaac ccaaaaaagg agtctttttg
     4201 ttagatgttc acctaaacag tacaatcgat gggttggatc tagcagaagc cattcgtaaa
     4261 aatgatgtaa atgcaaaaat agtatttatt acaacggatg aacacgctgc tcctttaaca
     4321 tttaagcgta atttagaagc tatgtcattc attgaaaaac cgtctaatgt agaggaatta
     4381 cgcaaaaata tttttgaaac actgaacatt gcatataata gattaactac ctctcttgac
     4441 gaaaaaaaac aattatttac tttttctaga tatggagaga cagttaatat tgattttgag
     4501 aaagttttat acctacagac tagtattgaa gaatcacaca aattaacgct aaccactaca
     4561 ttgggtgaat atgaattttc tggaagttta ataaagtgcg aagaaaattt ccctgaatta
     4621 ttccgtattt ccaaatcagc tttaattaac cctggtaatg ttgtgtctat caattataaa
     4681 aatcgtgata ttgtcctaaa aaacaatcat attattcagt atgctttcag acgtgctaaa
     4741 tcaatcaaag aaaaattttc taacccaaat aaaaactaat ataaaagccg ttacaactac
     4801 ttatgaagta taattgtaac ggcttttaaa tttaattcac tagctaagaa ataacttccc
     4861 ataatttttg atacgttcct ccagcatatc tcaacacttc atgaattcct tcttcaacta
     4921 aatctccttg atccataacc attattttct cacataattt agccgcaggt aagctatggg
     4981 taataaatat tatcgtacgt tctgtcattt ttataatatt atccattatt ctttgctcgg
     5041 agaagacatc tataccacta gttgcttcat caaaaataat aacttgtgag ttcgtaagta
     5101 atgctctaac aatcgctaag cgttgttttt gtccctttga taaatttgat cctgcttctt
     5161 caacaatcgt atgatattgc agaggtaatg attctataaa tgatttaata cacgctattt
     5221 cacaagcttg ttcaatttga ttttgagtcg gctcgtagtc taatccaaat aacaagttgt
     5281 ctcgaatcgt tcctgccaaa aagaatgaat cttgtggaac atatactata ttatgtctta
     5341 aaatatgcac atcaattgta ttaatatcat actttccgaa ataaatattt cccatagagg
     5401 ggtcataaaa ccgaaccaac attttagcta acgtagattt acctgatcca ctttcaccca
     5461 ctaatgctat tttatcaccc actttaattt cacatgttat gcctcttagt atcaattcac
     5521 caagcccata tgagaagtat acatcgtcaa actttaaatc tgcttctccc atttcttcaa
     5581 tttcaactgt atcgttacta atatttcctt caacttctat cgatagtata tcattcattc
     5641 gtcgactagc tacttgtgct ttttgaattt gtacctgtaa attaataaca ctctcaagcg
     5701 gttctgtaaa gaaaactaat aacgcgttat aagtaatcag tgctcctatg ctcatctcac
     5761 cactcatcac ataatatgct cctaaccata aaaccaacgc attccccacc agttgagtac
     5821 cggttttaat ggcgccctgc atattatcta atgtcattgt tgttaatgtt tttatcatta
     5881 aatcttcgaa ttccccaaca actctttgat aaataacttt ctcactattg tatgatttta
     5941 ttgtttcaat accatttaaa ctttcaataa tactggagtt tagtactgcc gctgattcca
     6001 tttcttcctc atttgactta tctaacttta tgataaacag tataattgtc ccaatgtaca
     6061 gaggtaatgt tactaaagtt acaccaaata atacattatg ttgaagcaat agaacgatgc
     6121 caaccacaac gaccattatg ctgtccaaaa gtaatgttaa ggatgtattg gctaatgcat
     6181 caatgattgt actagcatct aagaatctag agataatttc cccagattgt ctagacgcaa
     6241 aaaaacttat gggtaatttt aatacgtgtt taaaataatt taatatgata tccctactca
     6301 atttttgtcc taaaataaac aacaaataat ttctaatata tccaaatatc actcttaaca
     6361 catagctaat catcaatcca aatgaaataa tatttaacat tgaaatatta ttagctggaa
     6421 taattgaatc aattattcct tgaaaataat aagaactacc tatacttaat cccattataa
     6481 gcaatgatgc aataatcgaa aaaacaacaa atttcttata ctgaattatt ttaggaacaa
     6541 atgacatcaa tccttgaact ttttctttga taggtttata gtgccttcct ggtgaaggta
     6601 cgaatagtgt tcttgaccat actgcagaaa atgtttctat agacatatta tatttcccat
     6661 catctgggtc tgcaataaat aacttattat cttgataacc atacacaaca acataatgct
     6721 tcccattgtg tacattcaaa tgagcaatag ctggatatgt cattgctgaa tctgtccata
     6781 ctgcattatc tgcatcaata acaagacaat caaaatttaa tgattctaaa caccgcttta
     6841 tacctaatgc cgaagtgcct tgtttccctt tatctgttag atcttttagt ttatgaatag
     6901 agaattcaga attatagtga tgcaagatca tctggacaca ggctgtccca cagtccatat
     6961 tatcttgttg ataaattact ctaaagttgg tattcatttc atatgtctcc tattttcttc
     7021 actgactaac tatagtatga catctaattt atttatttga gtattcttcc ccaaacgtac
     7081 aaatttacta ccttatcgtt atcttttgaa attataccaa cttatcaaat aactaaataa
     7141 aaaattcccg taagacatat taaacactca caaatcatta ctgtgtagaa atatagaatt
     7201 taaagtcaat tttaagggtc ccaataaaat tttggatatt atcagtaaca tatatctgca
     7261 ttgctctaga gcttctttca tattttatat attatactaa ctcttccggt caattcgata
     7321 taaattattt tctatatgtt ttaaaaagat aagtgataat gaacatccag tcataaacat
     7381 gatgcgggca ctaaagatct ctcgagtaag tggcaaggcg atattgaacc ctattgtaaa
     7441 tagactcact tgaataagca ggccggccat gccattactt gaagcaccgt tacgataaaa
     7501 ataataacct ccataaagca acgtccctac aatcaccatc atgtgcacta tatcgaacaa
     7561 tggattataa gcagatggaa gatgatagag tatcattgct acatatgaaa taatgaatga
     7621 ctttaatcct tctttaaatc gcgtatgcat tagactcccc taatacataa ttagaaaatt
     7681 tctcaaattg atgtgactca ggaaaaataa atacattaaa aatgaagtaa aaaacaaata
     7741 aactaataaa aatatcttaa tatttgttta tattttcata aaaaacacct ctgaaaatat
     7801 tctatactat aataaaattt atccaactac tttaaggggt tcatttcgcc ccttaaaccc
     7861 caaaccagct gaatcagctg gaccatgcct ctggaatgag ttttttttac cctcttgctc
     7921 ttcaacatac caattcaact gattgagacg ttgagttaac gtgtcatttt tattcttcag
     7981 ctccatattt tcactagata attcagtgct ctttttttct ttcttgttaa cttccttagt
     8041 ctttttattc aatctcactt ccaattcatc tctaatttgc ataaattctt gagctttatc
     8101 tttttgggta tctatttcgc gtttcatctc tttatattct ctatgattca gataagaatg
     8161 tgtgccaact tgttttcgtt caatccgcct ctcgcccatc aaacgttcca attcagcaac
     8221 ttctctattt cgccaatctt taaaattttc cttggaatgc aatcgattag aattcttttg
     8281 agttttatta aaccccatat tctctagagc tcgattcatt gacacttgct tatctagccc
     8341 ttttacgctc ttatttttgt tacttttttg acaaaagtaa acgttttagc atgttgtcat
     8401 tccaatgtta ccatttccac aacaacatgt cagcgctctt cgaggacaaa agaagaataa
     8461 ggaaggggtg ttcccttcct tattcttctt tcgattcttc ttttatccta tccatttctt
     8521 ttctttctaa atacaactgt gttattacta aactaattaa tattgaagct atcataacaa
     8581 atatatggga tttgttttca ttaacaaata aatcaattac caaagatatt attgataatg
     8641 acagaattat ttgtaataag atattttttt tcttagacat ctaatctcct cctaaaaaat
     8701 actaatatta taaaaataat ctgaattgca acaaaagatg caataacttt ttggtgatat
     8761 tttctctgta tatcgatagt gcttttgggc ctttcaggag gcaattgcct cctgaaaggc
     8821 ttcaaatttt tcgttagctg ataatccatc aaataataat cgcgggtagt cattaattgt
     8881 gttctcgatt tcttttattt cattcaagct ccattgacta atgtcactcc ccttgggaat
     8941 aaatcgccga agaagtgtgt gcatctgttc atttgatcct cgctcataag aactgtaggg
     9001 ctgacacaat agaatagatg agtccgttta ttctcgcggg atttgacagt cccttctaag
     9061 gacttataat ctaggaattc cgagccatta tccactgtaa ttgatttaaa ttgctgtttg
     9121 aaccgttctg tccccaaaga gtcttctaat tcatctagtt gttttagcac ttgggcctgt
     9181 gtttgactcg tcatttttcg aataatcgat tttcgtgttt ttcgttcaac gagagttaac
     9241 agacatgttt tactgtgtcc tttcccagat tcgacacaat ccatttccca atgtccttct
     9301 tcttctcgat tgtttatcga ctcacttcga tacttaatca atcggttagg gggcacaact
     9361 ttttttcgtt ttttgacatg atgatatgtg cgtctttgtg tttttccttc tcggggtaaa
     9421 tggtcttgtg ttaacttctc aaacttatca gcattaatat aatgataaat tgttctcaaa
     9481 caaggaagtt gatcatgggt gaatttatct ccttttttta agtgttgtag cgctgcataa
     9541 ggcgaatatt tttgcgaaat aataatggtt tctattgctt ttaagacgga gtccccagga
     9601 ctaaactctg gatctggtcc tttatttgtt tttcctttat caatcttttc ttggacagca
     9661 ctagcggaat agatggtata ttctctccat aatggatctt tttgagtcac ttggcctcgt
     9721 cttaattctc ttgagatgat tgatggatga acccctaatt catctgccat atctgcttga
     9781 gtcaatcgct tatgcttagg gagctgacga ttttgacgag ccattttttc taaatattcc
     9841 cgatcatctt catctaaatg tttacctttt ggctttaatt tggtacactt aacttgagtc
     9901 atatttctct gtcctttctg tatgagtgta gatactatca gattaacaga gaatatggct
     9961 ttttttaagt gttttccttc ttgcatttaa ttatacaact cacctaaatc cataaatacc
    10021 aagtgaaatt tgaaatcaat tgatactatt gatacaatga aaatgcatta tatcatatat
    10081 ttaaatttct tataaaaaac taaaaaggcg gtgattatat tgaacggata ctataaaata
    10141 aataaatggt atatagagtt accattgttt ctaataactt ttttaatagg ttcatatttt
    10201 ataggaaatt tattaaatat gaatttcaac ataattactg aaatatttac aggaattgta
    10261 gcttggatac taattagatt tatatttaac aaaaaaagaa aggacagatc ataatgaaaa
    10321 agttcattaa agcaatactg gtagtattaa ctataagtat atttaatcca ttttttcagc
    10381 aaaagctagc gctcaatctt tagataataa cgaggaaata gaaacagctt tacaagaatc
    10441 tgttttttac gatgttagag aagaaaaatt cttaattgat gaaaaaaaag caaaagaaca
    10501 aggattaaat gaacatcaaa tttcaaatgt aaaagagttt ttcaattccc ttacccccga
    10561 aggaataaat caactaattg aaatgacaaa tattgaaaat gaaataagag aaataaaagc
    10621 aaaattagaa caaagagctg ttttcacaac cagtgcttta atcgctgctt taaaagcaat
    10681 tgggagtgga gttgcatcag caatagctgc ttcaatcgct aactatggac tatcaaaaac
    10741 atgcgaaaat gacagttggc gagattctat tgaaatgttt gataattact gcgaatcaaa
    10801 tgattggtaa aaaattcaat ataacaaaaa atatatgata taataagcat gtaattgtac
    10861 tagaaaagtc ttcatggttt atcaccataa agacaaaccc ccacaagttc gctataactt
    10921 gtgggggttt ttacgtcttg cgttgatttg tttgatatgc tccgtcaaaa aacattttca
    10981 ttatccctga accagattta aaaacactaa acaaattgga ttcattaggt aaatcatatt
    11041 catctttatg tagcttaata gttaatattg gccagaaaat acgttaacca gtataatgaa
    11101 caaacataag gagcgatttg atgaataaac atgaatataa caagatgatt cgcggcgaac
    11161 tatatgatcc ccgtgatccg tacttgcgcg acttgatgac aaaacaacat gccttaatgg
    11221 atgccttcaa cgaatcggac cgcaccgatc atgctactca aaataagttg ctagaggaat
    11281 tactgggcca atatcatggc gaaagcagtc atattcgtcg gccatttttt atcgattatg
    11341 gcctcaatat tacgatcggt aagcattttt ttgctaatta taattgcaca atgctggatg
    11401 tcgccccgat tacgatcggt aaaaacatca tgttcgggcc caacgttagc ttgaacactc
    11461 ctgaacatcc tctctcggca gctgagcgta atatgggatt agaatttgcc caaccgatca
    11521 ctattgaaga taatgtctgg attggcgcta gcgtcactgt tatcggtggt gtcactatcg
    11581 gacaaggagc cgtcattgcc gcgggtgccg ttgttactaa agatgtccct gccaataccg
    11641 ttgtcggtgg cattcccgca cgtgtactga aaaccattga gaattga
//
