GCF_003966625.1_ASM396662v1_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_AP018587.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-v,NRPS	63,900	134,663	capsular polysaccharide	Saccharide:Exopolysaccharide	4%
Region 2	NRPS	156,615	203,775	aureusimine	NRP	100%
Region 3	terpene,T3PKS	452,028	504,480
Region 4	siderophore	814,355	829,333	staphyloferrin A	Other:Non-NRP siderophore	100%
Region 5	cyclic-lactone-autoinducer	954,801	975,513

NZ_AP018587.1 - Region 1 - NRPS,lanthipeptide-class-v

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Location: 63,900 - 134,663 nt. (total: 70,764 nt) Show pHMM detection rules used

lanthipeptide-class-v: (APH and HopA1)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Lanthipeptides

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000410.1	0.40	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001699.1	0.39	Polyketide	nidulanin A	Aspergillus nidulans FGSC A4
BGC0001636.1	0.39	NRP	KK-1	Curvularia clavata
BGC0000551.1	0.36	RiPP	SapB	Streptomyces coelicolor A3(2)
BGC0000513.1	0.36	RiPP	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001591.1	0.36	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.36	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001207.1	0.34	NRP	teixobactin	Eleftheria terrae
BGC0001343.1	0.33	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000373.1	0.33	NRP	holomycin	Streptomyces clavuligerus ATCC 27064

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373.1	0.60	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0001343.1	0.57	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.56	NRP	pseudomonine	Pseudomonas fluorescens
BGC0000352.1	0.56	NRP	fimsbactin A	Acinetobacter sp. ADP1
BGC0001444.1	0.55	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.55	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000460.1	0.55	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0000323.1	0.55	NRP	cichofactin A, cichofactin B	Pseudomonas cichorii
BGC0000435.1	0.55	NRP	syringafactin	Pseudomonas syringae pv. tomato str. DC3000
BGC0000463.1	0.55	NRP	xantholysin A, xantholysin B, xantholysin C	Pseudomonas putida

Similar known gene clusters

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Lanthipeptides

NRPS/PKS products

NRPS/PKS monomers

Core peptide predictions

No core peptides found.

Predicted core structure(s)

For candidate cluster 1, location 63899 - 134663:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys - cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 88153 - 134663:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (cys - cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_90

Search NORINE for peptide: strict or relaxed

AMP-binding (26..434): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: plPslGGTCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

ctg1_91

Search NORINE for peptide: strict or relaxed

AMP-binding (549..946): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLSmIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

AMP-binding (1926..2320): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 100% (strong)

NZ_AP018587.1 - Region 2 - NRPS

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Location: 156,615 - 203,775 nt. (total: 47,161 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308.1	0.44	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1	0.27	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001637.1	0.27	NRP	kleboxymycin	Klebsiella oxytoca
BGC0000446.1	0.25	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001805.1	0.25	NRP	tilivalline	Klebsiella oxytoca
BGC0001652.1	0.24	NRP	limazepine C, limazepine D, limazepine E, limazepine F, limazepine A	Streptomyces sp. ICBB 8177
BGC0001132.1	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.23	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.22	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001627.1	0.22	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000308.1	0.75	NRP	aureusimine	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1	0.61	NRP	anabaenopeptin NZ857, nostamide A	Nostoc punctiforme PCC 73102
BGC0001637.1	0.60	NRP	kleboxymycin	Klebsiella oxytoca
BGC0000446.1	0.58	NRP	tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline	Klebsiella oxytoca
BGC0001805.1	0.58	NRP	tilivalline	Klebsiella oxytoca
BGC0001652.1	0.57	NRP	limazepine C, limazepine D, limazepine E, limazepine F, limazepine A	Streptomyces sp. ICBB 8177
BGC0001132.1	0.57	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.1	0.56	NRP	luminmide	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1	0.56	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001627.1	0.55	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv

Similar known gene clusters

Module view

Legend

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 4, location 156614 - 203775:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (val - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_143

Search NORINE for peptide: strict or relaxed

AMP-binding (422..812): val

NRPSPredictor2: val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: val

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWlGGTFK
Nearest Stachelhaus code:: val
Stachelhaus code match:: 90% (moderate)

AMP-binding (1447..1828): X

NRPSPredictor2: gly, ala, val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAmsfGAViK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

NZ_AP018587.1 - Region 3 - T3PKS,terpene

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Location: 452,028 - 504,480 nt. (total: 52,453 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001412.1	0.38	Saccharide	polysaccharide C	Bacteroides fragilis
BGC0000888.1	0.38	Other	bacilysin	Bacillus sp. CS93
BGC0001510.1	0.33	Other	anisomycin	Streptomyces hygrospinosus
BGC0000647.1	0.32	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000787.1	0.31	Saccharide	O-antigen	Escherichia coli
BGC0001156.1	0.30	Terpene	platencin	Streptomyces platensis
BGC0001140.1	0.30	Terpene	platensimycin, platencin	Streptomyces platensis
BGC0000839.1	0.29	Other	flexirubin	Chitinophaga pinensis DSM 2588
BGC0000799.1	0.29	Saccharide	colanic acid	Escherichia coli
BGC0001605.1	0.28	Terpene	gibberellin	Sinorhizobium fredii NGR234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.1	0.66	Terpene	carotenoid	Rhodobacter sphaeroides
BGC0000644.1	0.59	Terpene	carotenoid	Dietzia sp. CQ4
BGC0000635.1	0.59	Terpene	carotenoid	Paracoccus sp. N81106
BGC0000636.1	0.59	Terpene	carotenoid	Brevibacterium linens
BGC0000643.1	0.58	Terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.1	0.58	Terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.1	0.57	Terpene	carotenoid	Brevundimonas sp. SD212
BGC0000656.1	0.57	Terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000648.1	0.57	Terpene	carotenoid	Myxococcus xanthus
BGC0001227.1	0.56	Terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_AP018587.1 - Region 4 - siderophore

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Location: 814,355 - 829,333 nt. (total: 14,979 nt) Show pHMM detection rules used

siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.57	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.1	0.31	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.1	0.23	Other	aerobactin	Grimontia hollisae
BGC0000947.1	0.19	Other	vibrioferrin	Vibrio alginolyticus
BGC0000943.1	0.16	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000883.1	0.15	Other	arginomycin	Streptomyces arginensis
BGC0000666.1	0.14	Terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0001767.1	0.10	NRP	salinichelins	Salinispora pacifica CNY331
BGC0000423.1	0.10	NRP	scabichelin	Streptomyces scabiei 87.22
BGC0000708.1	0.09	Saccharide	lividomycin	Streptomyces lividus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.83	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001870.1	0.65	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000939.1	0.56	Other	aerobactin	Grimontia hollisae
BGC0000947.1	0.51	Other	vibrioferrin	Vibrio alginolyticus
BGC0000943.1	0.47	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000883.1	0.46	Other	arginomycin	Streptomyces arginensis
BGC0000666.1	0.43	Terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0001767.1	0.36	NRP	salinichelins	Salinispora pacifica CNY331
BGC0000423.1	0.35	NRP	scabichelin	Streptomyces scabiei 87.22
BGC0000708.1	0.34	Saccharide	lividomycin	Streptomyces lividus

Similar known gene clusters

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NZ_AP018587.1 - Region 5 - cyclic-lactone-autoinducer

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Location: 954,801 - 975,513 nt. (total: 20,713 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000540.1	0.12	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001687.1	0.12	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0001872.1	0.07	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001053.1	0.06	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0001130.1	0.06	NRP, Polyketide	fabclavine Ia	Xenorhabdus budapestensis
BGC0001700.1	0.04	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0000082.1	0.03	Polyketide	kijanimicin	Actinomadura kijaniata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000540.1	0.40	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0001687.1	0.40	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0001872.1	0.29	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001053.1	0.26	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0001130.1	0.25	NRP, Polyketide	fabclavine Ia	Xenorhabdus budapestensis
BGC0001700.1	0.18	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0000082.1	0.17	Polyketide	kijanimicin	Actinomadura kijaniata

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names