Select genomic region:
Overview
8.1
8.2
8.3
9.1
13.1
14.1
15.1
15.2
18.1
24.1
27.1
29.1
35.1
38.1
38.2
39.1
41.1
53.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_FOHN01000003 (original name was: NZ_FOHN01000003.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 8.1 | NRPS-like | 1 | 24,086 |
Region 8.2 | LAP,cyclic-lactone-autoinducer,RiPP-like | 28,938 | 60,401 | clostridiolysin S | RiPP:LAP | 22%
Region 8.3 | ranthipeptide | 99,961 | 121,292 |

NZ_FOHN01000020 (original name was: NZ_FOHN01000020.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | NRPS,resorcinol | 1 | 60,000 | equibactin | NRP | 14%

NZ_FOHN01000005 (original name was: NZ_FOHN01000005.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 13.1 | NRPS-like,NRPS,T1PKS | 109,263 | 173,442 |

NZ_FOHN01000016 (original name was: NZ_FOHN01000016.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 14.1 | ranthipeptide | 1 | 19,154 |

NZ_FOHN01000015 (original name was: NZ_FOHN01000015.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 15.1 | RiPP-like,ranthipeptide | 1 | 20,667 |
Region 15.2 | ranthipeptide | 48,133 | 69,500 |

NZ_FOHN01000012 (original name was: NZ_FOHN01000012.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 18.1 | other,cyclic-lactone-autoinducer,RiPP-like | 12,078 | 72,017 |

NZ_FOHN01000033 (original name was: NZ_FOHN01000033.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 24.1 | cyclic-lactone-autoinducer | 1 | 18,861 |

NZ_FOHN01000007 (original name was: NZ_FOHN01000007.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 27.1 | NRPS-like | 70,501 | 112,264 |

NZ_FOHN01000008 (original name was: NZ_FOHN01000008.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 29.1 | cyclic-lactone-autoinducer | 21,305 | 41,448 |

NZ_FOHN01000009 (original name was: NZ_FOHN01000009.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 35.1 | NRPS-like | 1 | 41,076 |

NZ_FOHN01000002 (original name was: NZ_FOHN01000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 38.1 | cyclic-lactone-autoinducer | 37,811 | 57,930 |
Region 38.2 | T1PKS,NRPS-like | 195,663 | 240,973 |

NZ_FOHN01000025 (original name was: NZ_FOHN01000025.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 39.1 | T1PKS,NRPS-like,prodigiosin | 1 | 43,929 |

NZ_FOHN01000018 (original name was: NZ_FOHN01000018.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 41.1 | transAT-PKS,NRPS-like | 30,761 | 67,945 |

NZ_FOHN01000045 (original name was: NZ_FOHN01000045.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 53.1 | RiPP-like | 1 | 6,195 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 8.1 | NRPS-like | 1 | 24,086 |
Region 8.2 | LAP,cyclic-lactone-autoinducer,RiPP-like | 28,938 | 60,401 | clostridiolysin S | RiPP:LAP | 22%
Region 8.3 | ranthipeptide | 99,961 | 121,292 |
Region 9.1 | NRPS,resorcinol | 1 | 60,000 | equibactin | NRP | 14%
Region 13.1 | NRPS-like,NRPS,T1PKS | 109,263 | 173,442 |
Region 14.1 | ranthipeptide | 1 | 19,154 |
Region 15.1 | RiPP-like,ranthipeptide | 1 | 20,667 |
Region 15.2 | ranthipeptide | 48,133 | 69,500 |
Region 18.1 | other,cyclic-lactone-autoinducer,RiPP-like | 12,078 | 72,017 |
Region 24.1 | cyclic-lactone-autoinducer | 1 | 18,861 |
Region 27.1 | NRPS-like | 70,501 | 112,264 |
Region 29.1 | cyclic-lactone-autoinducer | 21,305 | 41,448 |
Region 35.1 | NRPS-like | 1 | 41,076 |
Region 38.1 | cyclic-lactone-autoinducer | 37,811 | 57,930 |
Region 38.2 | T1PKS,NRPS-like | 195,663 | 240,973 |
Region 39.1 | T1PKS,NRPS-like,prodigiosin | 1 | 43,929 |
Region 41.1 | transAT-PKS,NRPS-like | 30,761 | 67,945 |
Region 53.1 | RiPP-like | 1 | 6,195 |

No secondary metabolite regions were found in these records:
  NZ_FOHN01000054 (original name was: NZ_FOHN01000054.1)
  NZ_FOHN01000052 (original name was: NZ_FOHN01000052.1)
  NZ_FOHN01000049 (original name was: NZ_FOHN01000049.1)
  NZ_FOHN01000048 (original name was: NZ_FOHN01000048.1)
  NZ_FOHN01000047 (original name was: NZ_FOHN01000047.1)
  NZ_FOHN01000021 (original name was: NZ_FOHN01000021.1)
  NZ_FOHN01000019 (original name was: NZ_FOHN01000019.1)
  NZ_FOHN01000053 (original name was: NZ_FOHN01000053.1)
  NZ_FOHN01000022 (original name was: NZ_FOHN01000022.1)
  NZ_FOHN01000017 (original name was: NZ_FOHN01000017.1)
  NZ_FOHN01000014 (original name was: NZ_FOHN01000014.1)
  NZ_FOHN01000013 (original name was: NZ_FOHN01000013.1)
  NZ_FOHN01000050 (original name was: NZ_FOHN01000050.1)
  NZ_FOHN01000011 (original name was: NZ_FOHN01000011.1)
  NZ_FOHN01000040 (original name was: NZ_FOHN01000040.1)
  NZ_FOHN01000001 (original name was: NZ_FOHN01000001.1)
  NZ_FOHN01000010 (original name was: NZ_FOHN01000010.1)
  NZ_FOHN01000042 (original name was: NZ_FOHN01000042.1)
  NZ_FOHN01000006 (original name was: NZ_FOHN01000006.1)
  NZ_FOHN01000004 (original name was: NZ_FOHN01000004.1)
  NZ_FOHN01000027 (original name was: NZ_FOHN01000027.1)
  NZ_FOHN01000024 (original name was: NZ_FOHN01000024.1)
  NZ_FOHN01000029 (original name was: NZ_FOHN01000029.1)
  NZ_FOHN01000032 (original name was: NZ_FOHN01000032.1)
  NZ_FOHN01000037 (original name was: NZ_FOHN01000037.1)
  NZ_FOHN01000031 (original name was: NZ_FOHN01000031.1)
  NZ_FOHN01000028 (original name was: NZ_FOHN01000028.1)
  NZ_FOHN01000034 (original name was: NZ_FOHN01000034.1)
  NZ_FOHN01000035 (original name was: NZ_FOHN01000035.1)
  NZ_FOHN01000026 (original name was: NZ_FOHN01000026.1)
  NZ_FOHN01000030 (original name was: NZ_FOHN01000030.1)
  NZ_FOHN01000038 (original name was: NZ_FOHN01000038.1)
  NZ_FOHN01000039 (original name was: NZ_FOHN01000039.1)
  NZ_FOHN01000023 (original name was: NZ_FOHN01000023.1)
  NZ_FOHN01000041 (original name was: NZ_FOHN01000041.1)
  NZ_FOHN01000044 (original name was: NZ_FOHN01000044.1)
  NZ_FOHN01000051 (original name was: NZ_FOHN01000051.1)
  NZ_FOHN01000036 (original name was: NZ_FOHN01000036.1)
  NZ_FOHN01000043 (original name was: NZ_FOHN01000043.1)
  NZ_FOHN01000046 (original name was: NZ_FOHN01000046.1)

Compact view
c00008_NZ_FOHN.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 24,086 nt. (total: 24,086 nt) Show pHMM detection rules used
Region on contig edge.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000895.1 |  | 0.20 | Other | citrulline | Lactobacillus plantarum subsp. plantarum
BGC0001833.1 |  | 0.17 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001314.1 |  | 0.14 | Terpene | tirucalla | Arabidopsis thaliana
BGC0001996.1 |  | 0.13 | Other | oryzine A, oryzine B | Aspergillus oryzae RIB40
BGC0001085.1 |  | 0.13 | NRP, Terpene | teleocidin B1 | Streptomyces blastmyceticus
BGC0001627.1 |  | 0.13 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0001575.1 |  | 0.13 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0001211.1 |  | 0.11 | NRP | albachelin | Amycolatopsis alba DSM 44262
BGC0000340.1 |  | 0.10 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0001872.1 |  | 0.09 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000895.1 |  | 0.52 | Other | citrulline | Lactobacillus plantarum subsp. plantarum
BGC0001833.1 |  | 0.48 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001314.1 |  | 0.44 | Terpene | tirucalla | Arabidopsis thaliana
BGC0001996.1 |  | 0.42 | Other | oryzine A, oryzine B | Aspergillus oryzae RIB40
BGC0001085.1 |  | 0.42 | NRP, Terpene | teleocidin B1 | Streptomyces blastmyceticus
BGC0001627.1 |  | 0.41 | NRP | isonitrile lipopeptides | Mycobacterium tuberculosis H37Rv
BGC0001575.1 |  | 0.41 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0001211.1 |  | 0.38 | NRP | albachelin | Amycolatopsis alba DSM 44262
BGC0000340.1 |  | 0.36 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0001872.1 |  | 0.33 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 24086:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg8_2: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (15..412): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      eL-dhGgICK
    Nearest Stachelhaus code:
      sal
    Stachelhaus code match:
      50% (weak)

c00008_NZ_FOHN.. - Region 2 - LAP,RiPP-like,cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 28,938 - 60,401 nt. (total: 31,464 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03882 or TIGR03604)) or TIGR03603 or TIGR03602) and not cyanobactin_synth)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | LAP | cyclic-lactone-autoinducer | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000617.1 |  |  |  | 0.73 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  |  |  | 0.66 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  |  |  | 0.66 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  |  |  | 0.66 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000624.1 |  |  |  | 0.62 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001171.1 |  |  |  | 0.61 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0001173.1 |  |  |  | 0.51 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.1 |  |  |  | 0.51 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0000554.1 |  |  |  | 0.50 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001356.1 |  |  |  | 0.49 | RiPP | paeninodin | Paenibacillus dendritiformis C454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001171.1 |  | 0.66 | RiPP | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0000617.1 |  | 0.62 | RiPP | coagulin | Bacillus coagulans
BGC0001173.1 |  | 0.61 | RiPP | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.1 |  | 0.61 | RiPP | plantazolicin | Bacillus velezensis FZB42
BGC0000488.1 |  | 0.60 | RiPP | circularin A | Clostridium beijerinckii
BGC0000624.1 |  | 0.59 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000619.1 |  | 0.59 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.59 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.59 | RiPP | gassericin E | Lactobacillus gasseri
BGC0001170.1 |  | 0.58 | RiPP | clostridiolysin S | Clostridium sporogenes ATCC 15579

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00008_NZ_FOHN.. - Region 3 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 99,961 - 121,292 nt. (total: 21,332 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000868.1 |  | 0.19 | Other | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0001410.1 |  | 0.17 | Saccharide | polysaccharide A | Bacteroides fragilis
BGC0000729.1 |  | 0.17 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000728.1 |  | 0.17 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000732.1 |  | 0.17 | Saccharide | capsular polysaccharide | Raoultella planticola
BGC0000733.1 |  | 0.17 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001588.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000794.1 |  | 0.17 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001589.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0000780.1 |  | 0.16 | Saccharide | O&K-antigen | Vibrio parahaemolyticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000868.1 |  | 0.51 | Other | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0001410.1 |  | 0.48 | Saccharide | polysaccharide A | Bacteroides fragilis
BGC0000729.1 |  | 0.48 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000728.1 |  | 0.48 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000732.1 |  | 0.48 | Saccharide | capsular polysaccharide | Raoultella planticola
BGC0000733.1 |  | 0.48 | Saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0001588.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0000794.1 |  | 0.48 | Saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0001589.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0000780.1 |  | 0.47 | Saccharide | O&K-antigen | Vibrio parahaemolyticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00009_NZ_FOHN.. - Region 1 - NRPS,resorcinol
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 60,000 nt. (total: 60,000 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))
resorcinol: DarB

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | resorcinol | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001343.1 |  |  | 0.47 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000412.1 |  |  | 0.43 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0001591.1 |  |  | 0.41 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  |  | 0.41 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000938.1 |  |  | 0.40 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000880.1 |  |  | 0.36 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0001281.1 |  |  | 0.36 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000347.1 |  |  | 0.36 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001636.1 |  |  | 0.36 | NRP | KK-1 | Curvularia clavata
BGC0001526.1 |  |  | 0.36 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 0.66 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000389.1 |  | 0.65 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001343.1 |  | 0.62 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001897.1 |  | 0.61 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000343.1 |  | 0.59 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001895.1 |  | 0.58 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000935.1 |  | 0.58 | Other (Aminocoumarin), Polyketide | esmeraldin | Streptomyces antibioticus
BGC0000236.1 |  | 0.58 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0000347.1 |  | 0.58 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0001444.1 |  | 0.57 | Other | caboxamycin | Streptomyces sp. NTK 937

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 60000:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys - cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 40528:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys - cys) + (cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg9_6: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (26..431): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGVLCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      100% (strong)
ctg9_7: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (550..947): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1972..2369): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLyNMSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg9_8: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (539..932): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNMSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg9_25: pk
  PKS_AT (70..285): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: trans-1,2-CPDA
  Prediction, score:
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Malonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg9_26: pk
  PKS_AT (10..288): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: trans-1,2-CPDA
  Prediction, score:
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Malonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

c00013_NZ_FOHN.. - Region 1 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 109,263 - 173,442 nt. (total: 64,180 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000427.1 |  |  |  | 0.97 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  |  |  | 0.96 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000465.1 |  |  |  | 0.93 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0001249.1 |  |  |  | 0.92 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000979.1 |  |  |  | 0.82 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  |  | 0.82 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  |  |  | 0.80 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001718.1 |  |  |  | 0.79 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0000426.1 |  |  |  | 0.78 | NRP | sevadicin | Paenibacillus larvae
BGC0000876.1 |  |  |  | 0.77 | Other | neopolyoxin C | Streptomyces tendae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.65 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000465.1 |  | 0.65 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0001249.1 |  | 0.64 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000979.1 |  | 0.62 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.62 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  | 0.60 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000876.1 |  | 0.60 | Other | neopolyoxin C | Streptomyces tendae
BGC0001718.1 |  | 0.60 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0000426.1 |  | 0.60 | NRP | sevadicin | Paenibacillus larvae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 109262 - 173442:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (mal) + (X) + (NMe-X - X) + (Me-mxmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 109262 - 148559:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (NMe-X - X) + (X) + (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 115726 - 168559:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (mal) + (X) + (NMe-X - X) + (Me-mxmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 128579 - 173442:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (mal) + (X) + (NMe-X - X) + (Me-mxmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg13_107: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (203..599): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKnvGVsvK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
ctg13_108: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (10..400): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      sfrAestgCK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      30% (weak)
ctg13_110: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (647..1052): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      GvfWIAcSGK
    Nearest Stachelhaus code:
      hiv-d
    Stachelhaus code match:
      70% (weak)
ctg13_111: X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (48..442): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmYSlGimWK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1501..1899): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmyeVGTvwK
    Nearest Stachelhaus code:
      lys-b
    Stachelhaus code match:
      50% (weak)
ctg13_112: mxmal
  PKS_AT (751..1037): mxmal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Methoxymalonyl-CoA
  Prediction, score:
    Methoxymalonyl-CoA: 31.3
    Malonyl-CoA: 29.9
    inactive: 25.3
    Methylmalonyl-CoA: 24.0
    3-Methylbutyryl-CoA: 3.7
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

c00014_NZ_FOHN.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 19,154 nt. (total: 19,154 nt) Show pHMM detection rules used
Region on contig edge.
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.23 | RiPP | siamycin | Streptomyces nodosus
BGC0000599.1 |  | 0.23 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001733.1 |  | 0.22 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000602.1 |  | 0.22 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001645.1 |  | 0.21 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001655.1 |  | 0.20 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000938.1 |  | 0.19 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001634.1 |  | 0.19 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001176.1 |  | 0.19 | RiPP | streptomonomicin | Streptomonospora alba
BGC0000601.1 |  | 0.18 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.57 | RiPP | siamycin | Streptomyces nodosus
BGC0000599.1 |  | 0.56 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001733.1 |  | 0.55 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000602.1 |  | 0.55 | RiPP | subtilosin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001645.1 |  | 0.54 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001655.1 |  | 0.52 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000938.1 |  | 0.52 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0001634.1 |  | 0.51 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001176.1 |  | 0.51 | RiPP | streptomonomicin | Streptomonospora alba
BGC0000601.1 |  | 0.50 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00015_NZ_FOHN.. - Region 1 - RiPP-like,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 20,667 nt. (total: 20,667 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000617.1 |  |  | 0.55 | RiPP | coagulin | Bacillus coagulans
BGC0000619.1 |  |  | 0.42 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  |  | 0.42 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  |  | 0.42 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000624.1 |  |  | 0.40 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.1 |  |  | 0.39 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  |  | 0.33 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001862.1 |  |  | 0.32 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  |  | 0.32 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  |  | 0.32 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.61 | RiPP | coagulin | Bacillus coagulans
BGC0000624.1 |  | 0.57 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000619.1 |  | 0.57 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.57 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.57 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000558.1 |  | 0.56 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.54 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.54 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.53 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00015_NZ_FOHN.. - Region 2 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 48,133 - 69,500 nt. (total: 21,368 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.16 | Other | nucleocidin | Streptomyces calvus
BGC0001285.1 |  | 0.11 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.47 | Other | nucleocidin | Streptomyces calvus
BGC0001285.1 |  | 0.38 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00018_NZ_FOHN.. - Region 1 - RiPP-like,cyclic-lactone-autoinducer,other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 12,078 - 72,017 nt. (total: 59,940 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or fom1 or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | cyclic-lactone-autoinducer | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000703.1 |  |  |  | 0.40 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001928.1 |  |  |  | 0.31 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000527.1 |  |  |  | 0.23 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000668.1 |  |  |  | 0.22 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001862.1 |  |  |  | 0.21 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  |  |  | 0.21 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001861.1 |  |  |  | 0.20 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.1 |  |  |  | 0.20 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000484.1 |  |  |  | 0.20 | RiPP | glycocin F | Lactobacillus plantarum
BGC0001289.1 |  |  |  | 0.20 | RiPP | penisin | Paenibacillus ehimensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.1 |  | 0.61 | RiPP | coagulin | Bacillus coagulans
BGC0001862.1 |  | 0.60 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.60 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001861.1 |  | 0.59 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001863.1 |  | 0.59 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000484.1 |  | 0.59 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000619.1 |  | 0.58 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001602.1 |  | 0.58 | RiPP | gassericin-T | Lactobacillus gasseri
BGC0001388.1 |  | 0.58 | RiPP | gassericin E | Lactobacillus gasseri
BGC0000624.1 |  | 0.57 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00024_NZ_FOHN.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 18,861 nt. (total: 18,861 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000851.1 |  | 0.20 | Other | albonoursin | Streptomyces noursei ATCC 11455
BGC0000896.1 |  | 0.17 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0001587.1 |  | 0.15 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000774.1 |  | 0.15 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001420.1 |  | 0.04 | NRP, Polyketide | myxochromide D | Hyalangium minutum
BGC0001418.1 |  | 0.04 | NRP, Polyketide | myxochromide D | Hyalangium minutum
BGC0001419.1 |  | 0.04 | NRP, Polyketide | myxochromide D | Hyalangium minutum
BGC0000469.1 |  | 0.04 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0001215.1 |  | 0.04 | NRP | conglobatin | Streptomyces conglobatus
BGC0000727.1 |  | 0.04 | Saccharide | indigoidine | Streptomyces aureofaciens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000851.1 |  | 0.52 | Other | albonoursin | Streptomyces noursei ATCC 11455
BGC0000896.1 |  | 0.47 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0001587.1 |  | 0.45 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001420.1 |  | 0.19 | NRP, Polyketide | myxochromide D | Hyalangium minutum
BGC0001418.1 |  | 0.19 | NRP, Polyketide | myxochromide D | Hyalangium minutum
BGC0001419.1 |  | 0.19 | NRP, Polyketide | myxochromide D | Hyalangium minutum
BGC0000469.1 |  | 0.19 | RiPP | bottromycin A2 | Streptomyces sp. BC16019
BGC0001215.1 |  | 0.18 | NRP | conglobatin | Streptomyces conglobatus
BGC0000727.1 |  | 0.17 | Saccharide | indigoidine | Streptomyces aureofaciens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00027_NZ_FOHN.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 70,501 - 112,264 nt. (total: 41,764 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.34 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.33 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000841.1 |  | 0.28 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000900.1 |  | 0.27 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.27 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000842.1 |  | 0.27 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000876.1 |  | 0.26 | Other | neopolyoxin C | Streptomyces tendae
BGC0000937.1 |  | 0.26 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000979.1 |  | 0.26 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.26 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.67 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.66 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000841.1 |  | 0.62 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000900.1 |  | 0.61 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.60 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000842.1 |  | 0.60 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000876.1 |  | 0.60 | Other | neopolyoxin C | Streptomyces tendae
BGC0000937.1 |  | 0.60 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0000979.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 70500 - 112264:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg27_78: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (8..407): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWqVSfIcK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      60% (weak)
ctg27_92: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (15..405): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVvqLAfVYK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      70% (weak)

c00029_NZ_FOHN.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 21,305 - 41,448 nt. (total: 20,144 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000725.1 |  | 0.17 | Saccharide | alginate | Pseudomonas aeruginosa PAO1
BGC0000619.1 |  | 0.06 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001388.1 |  | 0.06 | RiPP | gassericin E | Lactobacillus gasseri
BGC0001602.1 |  | 0.06 | RiPP | gassericin-T | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000725.1 |  | 0.48 | Saccharide | alginate | Pseudomonas aeruginosa PAO1
BGC0000619.1 |  | 0.26 | RiPP | gassericin T | Lactobacillus gasseri
BGC0001388.1 |  | 0.26 | RiPP | gassericin E | Lactobacillus gasseri
BGC0001602.1 |  | 0.26 | RiPP | gassericin-T | Lactobacillus gasseri

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00035_NZ_FOHN.. - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 41,076 nt. (total: 41,076 nt) Show pHMM detection rules used
Region on contig edge.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000427.1 |  |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  |  | 0.64 | NRP | indigoidine | Streptomyces chromofuscus
BGC0002002.1 |  |  | 0.57 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000921.1 |  |  | 0.54 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0000900.1 |  |  | 0.53 | Other | ferrichrome | Aspergillus oryzae
BGC0000876.1 |  |  | 0.53 | Other | neopolyoxin C | Streptomyces tendae
BGC0000980.1 |  |  | 0.51 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000979.1 |  |  | 0.51 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0001718.1 |  |  | 0.49 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0000426.1 |  |  | 0.47 | NRP | sevadicin | Paenibacillus larvae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.65 | NRP | indigoidine | Streptomyces chromofuscus
BGC0002002.1 |  | 0.62 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000921.1 |  | 0.61 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0000900.1 |  | 0.60 | Other | ferrichrome | Aspergillus oryzae
BGC0000876.1 |  | 0.60 | Other | neopolyoxin C | Streptomyces tendae
BGC0000980.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000979.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0001718.1 |  | 0.58 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0000426.1 |  | 0.57 | NRP | sevadicin | Paenibacillus larvae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 41076:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gln) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1 - 33033:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gln) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg35_13: gln
  Search NORINE for peptide: strict or relaxed
  AMP-binding (189..599): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAQDLGVVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      100% (strong)
ctg35_18: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..429): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      tdWQFGiIyK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      60% (weak)

c00038_NZ_FOHN.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 37,811 - 57,930 nt. (total: 20,120 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001469.1 |  | 0.04 | NRP | marthiapeptide A | Brevibacillus sp. Leaf182

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001469.1 |  | 0.17 | NRP | marthiapeptide A | Brevibacillus sp. Leaf182

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00038_NZ_FOHN.. - Region 2 - NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 195,663 - 240,973 nt. (total: 45,311 nt) Show pHMM detection rules used
Region on contig edge.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001264.1 |  |  | 0.43 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  |  | 0.43 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001560.1 |  |  | 0.39 | NRP, Polyketide | cryptomaldamide | Moorea producens JHB
BGC0001591.1 |  |  | 0.39 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  |  | 0.39 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000979.1 |  |  | 0.39 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  | 0.39 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000467.1 |  |  | 0.39 | NRP | yersiniabactin | Yersinia enterocolitica
BGC0000504.1 |  |  | 0.38 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.1 |  |  | 0.38 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001264.1 |  | 0.55 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae
BGC0001280.1 |  | 0.55 | Polyketide | betaenone C, betaenone A | Phoma betae
BGC0001560.1 |  | 0.52 | NRP, Polyketide | cryptomaldamide | Moorea producens JHB
BGC0001591.1 |  | 0.52 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.52 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000979.1 |  | 0.51 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.51 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000467.1 |  | 0.51 | NRP | yersiniabactin | Yersinia enterocolitica
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 195662 - 240973:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg38_215: X - mal
  Search NORINE for peptide: strict or relaxed
  AMP-binding (24..443): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      gLfaIGmVcK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      50% (weak)
  PKS_AT (1198..1485): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 79.2%
    2-Rhyd-Malonyl-CoA: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 140.7
    inactive: 107.8
    Methylmalonyl-CoA: 51.1
    Methoxymalonyl-CoA: 47.7
    Isobutyryl-CoA: 28.6
    Benzoyl-CoA: 24.4
    Propionyl-CoA: 24.0
    Acetyl-CoA: 17.2
    fatty_acid: 11.5
    Ethylmalonyl-CoA: 10.7
    trans-1,2-CPDA: 0.0
    CHC-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

c00039_NZ_FOHN.. - Region 1 - NRPS-like,T1PKS,prodigiosin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 43,929 nt. (total: 43,929 nt) Show pHMM detection rules used
Region on contig edge.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
prodigiosin: (PPDK_N and AMP-binding and PP-binding and PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS-like | prodigiosin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001273.1 |  |  |  | 0.62 | Polyketide | asperlactone | Aspergillus ochraceus
BGC0001400.1 |  |  |  | 0.61 | Polyketide | citreoviridin | Aspergillus terreus NIH2624
BGC0001163.1 |  |  |  | 0.60 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001268.1 |  |  |  | 0.59 | NRP, Polyketide | fusarin | Fusarium fujikuroi
BGC0000064.1 |  |  |  | 0.59 | Polyketide | fusarin | Fusarium verticillioides
BGC0001161.1 |  |  |  | 0.59 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001162.1 |  |  |  | 0.59 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0001998.1 |  |  |  | 0.57 | Polyketide | aspernidgulene A1, aspernidgulene A2, aspernidgulene B1 | Aspergillus nidulans FGSC A4
BGC0001050.1 |  |  |  | 0.56 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001187.1 |  |  |  | 0.56 | NRP, Polyketide | xenolozoyenone | Glarea lozoyensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001998.1 |  | 0.53 | Polyketide | aspernidgulene A1, aspernidgulene A2, aspernidgulene B1 | Aspergillus nidulans FGSC A4
BGC0001273.1 |  | 0.53 | Polyketide | asperlactone | Aspergillus ochraceus
BGC0001400.1 |  | 0.53 | Polyketide | citreoviridin | Aspergillus terreus NIH2624
BGC0001133.1 |  | 0.53 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001163.1 |  | 0.53 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001268.1 |  | 0.52 | NRP, Polyketide | fusarin | Fusarium fujikuroi
BGC0000064.1 |  | 0.52 | Polyketide | fusarin | Fusarium verticillioides
BGC0001560.1 |  | 0.52 | NRP, Polyketide | cryptomaldamide | Moorea producens JHB
BGC0001161.1 |  | 0.52 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001162.1 |  | 0.52 | Polyketide | 1-heptadecene | Moorea producens JHB

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 43929:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk) + (ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg39_15: pk - pk
  CAL_domain (163..477): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 81.0
    shikimic_acid: 0.0
    NH2: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  PKS_AT (1181..1446): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: trans-1,2-CPDA
  Prediction, score:
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Malonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg39_16: mal
  PKS_AT (1785..2074): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 75.0%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 162.9
    inactive: 100.7
    Methoxymalonyl-CoA: 54.2
    Methylmalonyl-CoA: 38.5
    Propionyl-CoA: 22.8
    fatty_acid: 17.6
    Isobutyryl-CoA: 9.8
    Ethylmalonyl-CoA: 9.1
    trans-1,2-CPDA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

c00041_NZ_FOHN.. - Region 1 - NRPS-like,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 30,761 - 67,945 nt. (total: 37,185 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001991.1 |  |  | 0.51 | Polyketide | toblerol A, toblerol B, toblerol C, toblerol D, toblerol E, toblerol F, toblerol G, toblerol H | Methylorubrum extorquens AM1
BGC0000044.1 |  |  | 0.46 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0000427.1 |  |  | 0.40 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001793.1 |  |  | 0.37 | Polyketide | swainsonine | Chaetothyriaceae sp.
BGC0001794.1 |  |  | 0.37 | Polyketide | swainsonine | Alternaria oxytropis
BGC0000180.1 |  |  | 0.35 | Polyketide | legioliulin | Legionella parisiensis
BGC0001164.1 |  |  | 0.35 | Polyketide | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001105.1 |  |  | 0.34 | NRP, Polyketide | onnamide A | Uncultured bacterium
BGC0001479.1 |  |  | 0.34 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001185.1 |  |  | 0.33 | NRP | bacillibactin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001991.1 |  | 0.59 | Polyketide | toblerol A, toblerol B, toblerol C, toblerol D, toblerol E, toblerol F, toblerol G, toblerol H | Methylorubrum extorquens AM1
BGC0000044.1 |  | 0.56 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0000427.1 |  | 0.53 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001793.1 |  | 0.50 | Polyketide | swainsonine | Chaetothyriaceae sp.
BGC0001794.1 |  | 0.50 | Polyketide | swainsonine | Alternaria oxytropis
BGC0000180.1 |  | 0.49 | Polyketide | legioliulin | Legionella parisiensis
BGC0001164.1 |  | 0.49 | Polyketide | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001105.1 |  | 0.48 | NRP, Polyketide | onnamide A | Uncultured bacterium
BGC0001479.1 |  | 0.48 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001185.1 |  | 0.48 | NRP | bacillibactin | Bacillus velezensis FZB42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 30760 - 67945:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (ccmal - ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 41075 - 67945:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (ccmal - ccmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg41_46: mal
  PKS_AT (6..283): mal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 25.1
    Methoxymalonyl-CoA: 20.9
    Methylmalonyl-CoA: 13.5
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg41_50: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (240..628): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      iPkqvldsaK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      20% (weak)

c00053_NZ_FOHN.. - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 6,195 nt. (total: 6,195 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.30 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001291.1 |  | 0.14 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000607.1 |  | 0.05 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000557.1 |  | 0.04 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.63 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001291.1 |  | 0.44 | RiPP | enterocin NKR-5-3B | Enterococcus faecium
BGC0000607.1 |  | 0.24 | RiPP | micrococcin P1 | Macrococcus caseolyticus
BGC0000557.1 |  | 0.18 | RiPP | streptococcin A-FF22 | Streptococcus pyogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names