LOCUS       NC_015275.1            12178 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_015275.1 Cellulosilyticum lentocellum DSM 5427, complete
            sequence.
ACCESSION   NC_015275
VERSION     NC_015275.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:12:07
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3992583
            Orig. end    :: 4004761
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12178
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3997583:3999761](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7178)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12178
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12178
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(2230..3165)
                     /locus_tag="ctg1_3646"
                     /transl_table=11
                     /translation="MKQIYKTFDAGLKAIESFEEGAWINLINPTPQEINEISEAFNIEV
                     NHILSALDEEERARIEVDDNCTVIIVDVPIKETEEGMGDYATIPMTIILGDKFIITTCL
                     KNIQLLEDFSSGKIRGFFTYKKTRFILQLLYKNASYYLQYLRHIDRMSHKIEQELHKSM
                     KNKELIQLLDLEKSLVYFTTSLRSNEIVLEKMMRMENVKQYPEDEDLLEDVIIENKQAI
                     EMANIYSNILSGTMDAFASVISNNLNIVMKTLTSITIVMSVPTMIASFWGMNVIVPFQD
                     GSPYAFVGIVAFSIALTVLLALFMIRKKLF"
     PFAM_domain     complement(2245..3105)
                     /aSDomain="CorA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01544.20"
                     /description="CorA-like Mg2+ transporter protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3646_0084"
                     /evalue="3.50E-56"
                     /label="ctg1_3646"
                     /locus_tag="ctg1_3646"
                     /protein_end="307"
                     /protein_start="20"
                     /score="190.8"
                     /tool="antismash"
                     /translation="GAWINLINPTPQEINEISEAFNIEVNHILSALDEEERARIEVDDN
                     CTVIIVDVPIKETEEGMGDYATIPMTIILGDKFIITTCLKNIQLLEDFSSGKIRGFFTY
                     KKTRFILQLLYKNASYYLQYLRHIDRMSHKIEQELHKSMKNKELIQLLDLEKSLVYFTT
                     SLRSNEIVLEKMMRMENVKQYPEDEDLLEDVIIENKQAIEMANIYSNILSGTMDAFASV
                     ISNNLNIVMKTLTSITIVMSVPTMIASFWGMNVIVPFQDGSPYAFVGIVAFSIALTVLL
                     ALFMIR"
     CDS             complement(3472..5001)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 79.9; E-value:
                     2.9e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_3647"
                     /transl_table=11
                     /translation="MKAIIKNINELSDSKELYETKPNPFFAIFIGLLIGIVVAAIIWMY
                     YGEIDIVSKGRGMIRPNEQLSIIRNKSGGVVNSSSLQEGKRVKAGDVLVTIDCAEQEVK
                     KLQLQEVISEQEKILDNLRTLKKSIESSVNSFNSEHDEAYVQKYIQYEQDFETLKRSQI
                     IDSQNEEIDLKQVNLNKASYTEKIKKAEKDIAGLETLKQSVNEEKSIFKDIDSIYAIEF
                     ETYLYDRDALKSKLEEAKTLYNLNVELDEQNLVAKEELKASKQKVGELKNQLDTQKLTL
                     LKEVEEKIEANQTIIDTSTIENNKLIISEELLKNKVAKRKLALEQFKTGELVKLDNQIQ
                     ELEVQYQSDKRNLEGIQIAIDDCTIRASIDGTLNVVQEINKGDLLTEGTELGKIIPVSD
                     SIYKVEIFVPNNDIAGLKVGQEIEYQFDALSYREYGKIKGHITNISTDASQTELGGMSG
                     YWITGSLEDVNLYSYKNEPADLKIGMSCNAYIITEQKKILYYVLEKINLKE"
     PFAM_domain     complement(3652..3912)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3647_0085"
                     /evalue="2.80E-12"
                     /label="ctg1_3647"
                     /locus_tag="ctg1_3647"
                     /protein_end="450"
                     /protein_start="363"
                     /score="47.3"
                     /tool="antismash"
                     /translation="TIRASIDGTLNVVQEINKGDLLTEGTELGKIIPVSDSIYKVEIFV
                     PNNDIAGLKVGQEIEYQFDALSYREYGKIKGHITNISTDASQ"
     CDS             complement(5001..7178)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     261.5; E-value: 9.5e-80)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 327.8; E-value:
                     2.2e-99)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_3648"
                     /sec_met_domain="TIGR01193 (E-value: 1.8e-212, bitscore:
                     705.6, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.2e-40, bitscore:
                     133.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKYYCIMQYDMTDCGAACLATVCKQYGLSTPITKIREAAGTDTE
                     GTNVAGMLEAAEKLGFSAKGVKGEPEALLGEFPLPAIAHVIKEGGLMHYVVVHKITKHE
                     IIIADPADGIVTYSFEDFTRIWSGVLILLVPTSEFKKGKETKGLFERFLHLLKPQKGIV
                     LQVFAASLLYTALGILGAFYMQFLLDDILPYNMSKTLNILSIGILILYTFQMLLSLFRS
                     HLLLFLSQKLDIALLLGYYEHILKLPMNFFGTRRVGEIISRFQDAGHVRDAISGATLTI
                     MIDTIMVIVGGIILYMQNALLFGITLVVALLYGVVVVSFNKTLKKGNKATMENNAQLTS
                     YMVESLNGIQTVKVFNAEKKVGIETETKFIKLLRSIFKLSFTTNLQGFFKGLIELLGGV
                     VILWIGANQVLQGDMSVGNLITYNSLLIYFLNPIKNLINLQPQLQTAMVAAERLGEILD
                     LEIENGEEESRKMEPKHLEGEISYKNVTFKYGQRQNVLEEINLEIKPGERIALVGESGS
                     GKTTLAKLLLNLYPLEEGEILIDNNNILDIKKEVLRTKIAYVPQETFLFSGTIMENLAL
                     GLERISMEEIVEASKMAKAHDFINELPLRYETLLDENGANLSGGQRQRLAIARAILKKP
                     NILILDEATSNLDSITEAAIESTIRQLSRSMSTIIIAHRLSTIKLCDRIYVLDKGRIVE
                     TGTHKELVSIGGRYASLWREQISGLEVGEVN"
     aSDomain        complement(5043..7154)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_3648_0028"
                     /evalue="1.80E-212"
                     /identifier="TIGR01193"
                     /label="ctg1_3648"
                     /locus_tag="ctg1_3648"
                     /protein_end="712"
                     /protein_start="8"
                     /score="705.6"
                     /tool="antismash"
                     /translation="QYDMTDCGAACLATVCKQYGLSTPITKIREAAGTDTEGTNVAGML
                     EAAEKLGFSAKGVKGEPEALLGEFPLPAIAHVIKEGGLMHYVVVHKITKHEIIIADPAD
                     GIVTYSFEDFTRIWSGVLILLVPTSEFKKGKETKGLFERFLHLLKPQKGIVLQVFAASL
                     LYTALGILGAFYMQFLLDDILPYNMSKTLNILSIGILILYTFQMLLSLFRSHLLLFLSQ
                     KLDIALLLGYYEHILKLPMNFFGTRRVGEIISRFQDAGHVRDAISGATLTIMIDTIMVI
                     VGGIILYMQNALLFGITLVVALLYGVVVVSFNKTLKKGNKATMENNAQLTSYMVESLNG
                     IQTVKVFNAEKKVGIETETKFIKLLRSIFKLSFTTNLQGFFKGLIELLGGVVILWIGAN
                     QVLQGDMSVGNLITYNSLLIYFLNPIKNLINLQPQLQTAMVAAERLGEILDLEIENGEE
                     ESRKMEPKHLEGEISYKNVTFKYGQRQNVLEEINLEIKPGERIALVGESGSGKTTLAKL
                     LLNLYPLEEGEILIDNNNILDIKKEVLRTKIAYVPQETFLFSGTIMENLALGLERISME
                     EIVEASKMAKAHDFINELPLRYETLLDENGANLSGGQRQRLAIARAILKKPNILILDEA
                     TSNLDSITEAAIESTIRQLSRSMSTIIIAHRLSTIKLCDRIYVLDKGRIVETGTHKELV
                     SIGGRYASLW"
     PFAM_domain     complement(5244..5693)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3648_0088"
                     /evalue="9.70E-39"
                     /label="ctg1_3648"
                     /locus_tag="ctg1_3648"
                     /protein_end="645"
                     /protein_start="495"
                     /score="133.1"
                     /tool="antismash"
                     /translation="LEEINLEIKPGERIALVGESGSGKTTLAKLLLNLYPLEEGEILID
                     NNNILDIKKEVLRTKIAYVPQETFLFSGTIMENLALGLERISMEEIVEASKMAKAHDFI
                     NELPLRYETLLDENGANLSGGQRQRLAIARAILKKPNILILDEATS"
     PFAM_domain     complement(5883..6683)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3648_0087"
                     /evalue="8.00E-48"
                     /label="ctg1_3648"
                     /locus_tag="ctg1_3648"
                     /protein_end="432"
                     /protein_start="165"
                     /score="163.6"
                     /tool="antismash"
                     /translation="VFAASLLYTALGILGAFYMQFLLDDILPYNMSKTLNILSIGILIL
                     YTFQMLLSLFRSHLLLFLSQKLDIALLLGYYEHILKLPMNFFGTRRVGEIISRFQDAGH
                     VRDAISGATLTIMIDTIMVIVGGIILYMQNALLFGITLVVALLYGVVVVSFNKTLKKGN
                     KATMENNAQLTSYMVESLNGIQTVKVFNAEKKVGIETETKFIKLLRSIFKLSFTTNLQG
                     FFKGLIELLGGVVILWIGANQVLQGDMSVGNLITYNSLLIYFLNP"
     PFAM_domain     complement(6768..7169)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3648_0086"
                     /evalue="3.70E-39"
                     /label="ctg1_3648"
                     /locus_tag="ctg1_3648"
                     /protein_end="137"
                     /protein_start="3"
                     /score="133.7"
                     /tool="antismash"
                     /translation="YYCIMQYDMTDCGAACLATVCKQYGLSTPITKIREAAGTDTEGTN
                     VAGMLEAAEKLGFSAKGVKGEPEALLGEFPLPAIAHVIKEGGLMHYVVVHKITKHEIII
                     ADPADGIVTYSFEDFTRIWSGVLILLVPTS"
     CDS             complement(7342..7479)
                     /locus_tag="ctg1_3649"
                     /transl_table=11
                     /translation="MKKIKEVNKVEHFKELSKREKQKISGGALAYCSAVMREFISIFIP
                     "
     CDS             complement(7585..8898)
                     /locus_tag="ctg1_3650"
                     /transl_table=11
                     /translation="LDKLDLLAGLINCFVMQSMCLNAFLDKAQLTRKRIIKYLLYVGVI
                     CAFMFITHQKVISGVLFFGVCFANFLFEGTFLNKVWVNFLGLAVIYGIGTLDWMLIDYI
                     VEHYGHTWLENQIVTEIRCALEGTILWFLGKQSNIIYKASGQYKTVTRRQALAIILLTI
                     TAMYTLFICDAAYFGDIELLQSISVGTYILIFFICIIILILGINEEMNKLYYKWSNECM
                     SEQLERQFKYYHKLEEINKETRAIKHDMRNHMIIIRSLAQQGELHKLEQYIAEMENTTE
                     RLDYMVHTGHSIVDAILNDKLQIAKEKNIQMEYEVKFSKQLGLDDMDLCVIFANSLDNA
                     IEACERVEASRVKRIQMKAVCDRGYLFYNIKNTANGRVEIDHKKEIPTNKKDSINHGFG
                     LANIRKSVQKNNGNINIISKEEEFYLEIDIPISYSVTA"
     PFAM_domain     complement(7612..7926)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3650_0089"
                     /evalue="2.70E-23"
                     /label="ctg1_3650"
                     /locus_tag="ctg1_3650"
                     /protein_end="429"
                     /protein_start="324"
                     /score="81.9"
                     /tool="antismash"
                     /translation="DDMDLCVIFANSLDNAIEACERVEASRVKRIQMKAVCDRGYLFYN
                     IKNTANGRVEIDHKKEIPTNKKDSINHGFGLANIRKSVQKNNGNINIISKEEEFYLEID
                     I"
     CDS             complement(8891..9613)
                     /locus_tag="ctg1_3651"
                     /transl_table=11
                     /translation="MFRIFVCDDEEVFRKHLEALLEEYLKSRVKQYEIQYFSSAEELLK
                     ANYEQCDVFCLDVEIENSINGITLAKKIRQKNLKADIIFTTSHPEEAHCAFEVNTLRYL
                     LKPIQKEQLFKTFDLILKKRKEKLSKLITLNQGQRFFQIPFADIIYFETVDRKLRAVTS
                     QKEYIIDNKINEVDKFVADKGFFRIHKSYLINLAYVKEYDQATVTMQNGDVVYMSRLRI
                     KAFKESFRLYLKEAHRLG"
     PFAM_domain     complement(8930..9199)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3651_0091"
                     /evalue="1.10E-22"
                     /label="ctg1_3651"
                     /locus_tag="ctg1_3651"
                     /protein_end="228"
                     /protein_start="138"
                     /score="80.2"
                     /tool="antismash"
                     /translation="RFFQIPFADIIYFETVDRKLRAVTSQKEYIIDNKINEVDKFVADK
                     GFFRIHKSYLINLAYVKEYDQATVTMQNGDVVYMSRLRIKAFKES"
     PFAM_domain     complement(9266..9604)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_3651_0090"
                     /evalue="2.70E-15"
                     /label="ctg1_3651"
                     /locus_tag="ctg1_3651"
                     /protein_end="116"
                     /protein_start="3"
                     /score="56.6"
                     /tool="antismash"
                     /translation="IFVCDDEEVFRKHLEALLEEYLKSRVKQYEIQYFSSAEELLKANY
                     EQCDVFCLDVEIENSINGITLAKKIRQKNLKADIIFTTSHPEEAHCAFEVNTLRYLLKP
                     IQKEQLFKT"
ORIGIN
        1 gccaaaatac taggtacctt tgtgacatca ctatgataga aaccattaac atcatataag
       61 ctactaatga gtccatcatc ttcacctggt actactacta aagcattaga tacaacttct
      121 tctataccat ctgccataac ggtaatatcc atctgtccac cttgatccca gttggttaag
      181 ttattagtac catataaagt agcacctgta ccgtacatta aacgatctga gttaaatggg
      241 tcaatatcta tagcccctac acaccaaccc aacttaggga aaatttcagc acttccacct
      301 gcttgacttt tattccccca atctaaccat ggtgcatctg aaatatccat cttatagtag
      361 agcttacgat ctggataact tgtccattcc caaacattct tccaagtttc tccaccatct
      421 gtacttctat acatgaagat atctggccac caggattggc aaataaccac aatattatct
      481 tcattttgtg ggtctacagc aataccatta taaggatagt aaggatcatc aggtgctgtt
      541 ttacttgatt taggactaat aagtgtccac gtatctgtat tcgtatcaaa tttccataca
      601 tcaccataac ctgtttcata aggtcctgcc gtagttgagt aagttacata aagaatgcca
      661 tctttagtaa gataagattg ataaggtaag taagttaccc cctcctctat tttccattca
      721 cctgttgttt cattggttac ttttcctcta ggttcattag ggagtgcttc ccatgtctta
      781 ccgccatctt tgcttctata aatagaatgt gcctgatctc ctacacctac ataaatagtt
      841 tgagaacctg agcctacttt atttgaattc tcatcacaaa ttacccaggt taaacctaga
      901 ttaccttcat actgcgttcc tttgtcgtac ttaaaagttc ccttggtggg aaatgaagtc
      961 acttctttcc aagtgtgccc ataatcttca ctcttccata aaccattatt acgtgatgca
     1021 agatacaagt tagaattttt attaggatca actatcaacc tatctcccat tagtcttcct
     1081 tgcatattac taccacagaa aaatggtaat tctactacgt cccaagtctc tcctttatca
     1141 ttagaacaaa atactgctcc gggtacatct gtccaaccat tatcatattc tcccatcagt
     1201 gcataaacac ggttagggtc tgttggatct gtagcaatac catcacaacc tagattactc
     1261 catgtttctg gtcctaccca gtcagtaaga ggtttccagc tcccagtatc ttcctgccag
     1321 cggtaaatac cacccatatc cgttctagca tagataagat tttcttctgc ttcactaaaa
     1381 gtaatacctg taatcattcc cccaccataa atttgtacat tcttccactc attggtttca
     1441 gcactatagg catatacaca attaggcgca atacacatca ttgctagtcc aataggtaaa
     1501 acaaactttc ttgcataaca gctaatagct tgtcttaact tactcaatat tctcttactc
     1561 atcatacccc tcctagatta ataaaacact tttataaagc atctttatta atttcattta
     1621 tgcctctatt atattacgct ccttatgtag tccaatatgg ttctcccaag atgcattatt
     1681 tttatacata atatgccttt tataaaaaag ttgtaactat tcagctatac aaacagaaat
     1741 ttgtcggggg tgtttatgag aattacgtct ggaggaaaat gagggggctt ttcttttttg
     1801 aaaacacttc aagagagtgg ctttacgcat tattgttgat atctattttc tgcacttctc
     1861 gtttaggggc cccagcgttt atgagattaa taacgcttgt aagaaatgat aggataaggg
     1921 ctgcctgaag gaatgacttc gtagtatttt ttagaagcac ttggtgaact tttttgatgg
     1981 gttttagtgc gagtgtttga ctgaaaggag ttttcgcacg ttcatcaaaa aaatgagcct
     2041 tagtgcttca aaaaatacgg agcggaattc cggaaggtag cccttatcct atcatttccg
     2101 cccaacagta tcctcatcaa cgacacgaca catttctaaa tagttatgac ataaagctta
     2161 acccgcacgc aaaaatagct atacttctaa caagtttaaa cttattagga gtatagctat
     2221 tttatctatt taaaataatt tttttctaat cataaataat gctagtaata ctgtcaaagc
     2281 aattgagaaa gctactattc ccacaaaagc atatgggctg ccatcttgga atggtactat
     2341 aacgttcatt ccccagaaac tagcaatcat tgttggcaca gacataacaa tagtaatcga
     2401 agtaagagtc ttcatcacaa tatttaagtt gttagaaata acagatgcaa atgcatccat
     2461 ggttccactt aaaatgttac tgtaaatgtt ggccatctca atagcctgtt tattttcaat
     2521 aataacatct tctagcaaat cttcatcctc tggatattgc tttacatttt ccattctcat
     2581 catcttctca agtacaattt cattagaacg aagtgatgtt gtaaagtata ctaaactctt
     2641 ttccaaatca agaagctgaa taagctcttt attcttcata gatttatgaa gctcttgttc
     2701 aatcttatga ctcatacgat cgatgtgtct taagtattgt aagtagtaag acgcattttt
     2761 ataaagaagc tgtaatataa atcttgtttt cttataggta aagaaacctc taattttacc
     2821 agaactaaaa tcctctagta actgaatatt ttttaagcaa gttgtaataa tgaacttatc
     2881 gcctaaaata atagtcattg gaatggtagc ataatcaccc ataccttctt ctgtttcttt
     2941 aataggtacg tctacgataa taactgtaca gttatcatct acttcaatac gagctctttc
     3001 ctcttcatcc agtgcggata aaatatgatt aacttcaata ttgaaagcct cagaaatttc
     3061 gttaatctct tgtggtgtag gattaattaa attaatccat gcgccttctt cgaaggattc
     3121 aatagctttt agccctgcat caaatgtttt ataaatttgt ttcatctttt cacatcctcc
     3181 acccctcacc tttttagtgc aagtggtgat tttgtgacag cacaaaaagc tacctttgca
     3241 ttaaaacaag gtgagtattc tcattattta attgattttt taaacgccta taactcggtc
     3301 cgacgtccac ggatactcac actcccttta gtatttatca ttttttattt ttaatacaaa
     3361 gactttctta atttaagcct cttctatact attttattat aaatcacctg tcaagcaaat
     3421 ttacttgtag gaagcaaaaa aatcttcgtt cctacaagta aacctgaatc attattcttt
     3481 taaattgatt ttttctaaaa catagtacaa tattttcttt tgttctgtga taatgtatgc
     3541 attacagctc ataccaattt ttaaatcagc gggctcattt ttgtaactgt aaagatttac
     3601 atcttctaga ctaccagtta tccaataacc actcattcct cctaattctg tttgactagc
     3661 atctgtagaa atattagtaa tatgaccctt gatcttgcca tactcgcggt aggaaagtgc
     3721 atcaaattga tattcgattt cctgtccaac cttaagacct gctatatcat tattgggaac
     3781 aaagatctca accttataaa tactatcact aacgggaatt attttcccaa gttctgttcc
     3841 ctccgttaat aaatcacctt tattaatttc ttgtactaca tttaaggttc catctatgga
     3901 agcacgtata gtacaatcat ctatagctat ctgtatacct tctagattcc tcttatccga
     3961 ttgatattga acttctagtt cttggatttg attatctaac ttgactagtt cacctgtctt
     4021 aaactgctca agtgctaatt ttcttttggc tactttattt ttcaggagtt cctcactaat
     4081 aattagttta ttattctcta tagtagatgt gtctattata gtttgattgg cttcaatttt
     4141 ttcttccact tctttaagta gtgttagctt ttgtgtatct aattgatttt tgagttcccc
     4201 tactttttgt ttagaagctt ttaattcttc tttggctacc aaattctgtt catctaactc
     4261 tacatttagg ttataaagtg tttttgcctc ttctaattta ctctttaaag catccctatc
     4321 atacagatat gtctcaaact ctattgcata gatactatct atatctttaa aaatagactt
     4381 ttcctcatta acagattgtt taagcgtttc taagcctgct atatctttct ctgctttttt
     4441 tattttttct gtatagcttg ccttattcaa attcacctgt tttaggtcta tctcctcgtt
     4501 ttgactatcg attatctggc tcctttttag agtctcaaaa tcttgttcat actggatgta
     4561 cttttgtaca taagcttcat catgctcact attaaagcta tttacgctac tttcaatact
     4621 tttcttcaag gttcttagat tgtctaatat cttctcttgt tcgcttatca cttcttgtaa
     4681 ctgtaatttc tttacttcct gctctgcaca gtcaattgtt actaagacat ctccagcttt
     4741 tactcgtttt ccctcttgca aactgctact attaacaact ccacctgatt tatttcttat
     4801 aatacttaat tgttcattgg gtctaatcat gcccctaccc ttagatacaa tatcaatctc
     4861 cccataatac atccatataa tagctgccac aactattcct atcaatagtc cgataaaaat
     4921 ggcaaagaag ggattaggtt tggtctcata gagttcttta ctatctgata actcatttat
     4981 atttttaata atggctttca ttagtttacc tcccccactt ctaatcctga tatttgttct
     5041 ctccataagg atgcatatct accacctata cttactagtt ccttatgtgt ccctgtttct
     5101 acgattcttc ctttatctaa tacgtagatg cgatcacata atttaatagt acttaatcga
     5161 tgtgcaataa taatggtgct catggaccga cttagctgtc taatagtaga ttctatagct
     5221 gcttcggtaa ttgagtctaa attactagta gcttcatcta aaattaaaat attaggcttc
     5281 tttaatatag cccttgctat agctagcctc tgcctctgac cacctgataa gttggcacca
     5341 ttctcatcta gaagtgtttc atatcttagt ggaagttcat tgataaaatc atgtgcttta
     5401 gccatcttgg atgcttctac tatttcttcc atactgatac gctctaaacc tagggctaga
     5461 ttttccataa ttgtcccact gaataaaaag gtttcttgtg ggacataagc aatcttggtt
     5521 ctaaggacct cttttttaat atctaggata ttattgttgt ctattaatat ttcaccttct
     5581 tctaacgggt ataaattaag taatagtttg gctaaagtcg ttttacccga accactttct
     5641 cctactaatg caattctttc tcctggctta atctctaaat taatctcttc taacacgttc
     5701 tgcctttggc catatttaaa agtgacattt ttataagaaa tttctccctc taaatgcttt
     5761 ggctccatct ttctagattc ttcttctcca ttttctatct ctaaatctaa gatttcacct
     5821 aatcgctctg ctgcaaccat agctgtttga agctgaggtt gtaaattaat taaattttta
     5881 ataggattta aaaaataaat gagtaatgaa ttatatgtaa ttaaattacc tacggacata
     5941 tctccttgaa ggacttgatt ggcaccaatc cataatatga caacgcctcc aagtaattct
     6001 attaagcctt taaaaaagcc ttgcaagttc gtcgtaaaac ttagtttgaa gatacttctt
     6061 agtagcttaa tgaattttgt ttctgtttct atccctactt ttttctctgc attaaagacc
     6121 ttaacggttt gaataccatt tagtgactcc accatgtacg aagtaagttg tgcgttattt
     6181 tccatggtag ctttattgcc cttcttcaag gttttattaa aactcactac taccacgcca
     6241 tagagcagag cgaccactaa ggtgattcca aacagtagcg cattttgcat atataaaata
     6301 atgcctccta ctattaccat aatcgtgtcg atcattatgg ttagcgttgc tcctgatata
     6361 gcatctctta catgccctgc atcttgaaac ctagaaataa tctcacctac tcttcttgtc
     6421 ccaaaaaagt tcataggtaa ttttagaata tgctcataat aacctaataa tagagctata
     6481 tctaatttct ggctcaaaaa aagtaataag tgggacctga ataaactaag tagcatctga
     6541 aaagtgtaaa gtattagaat gccaatggat aggatattta aagttttgga catattatag
     6601 ggcaaaatat catctagtaa aaattgcata taaaatgctc ctaatatgcc taatgctgta
     6661 taaagaagtg atgccgcaaa tacttgtagc acaatacctt tttgtggctt aagtaaatga
     6721 agaaaacgct caaataagcc ctttgtttcc tttcctttct taaattcact ggttggcact
     6781 aataaaataa gcaccccaga ccatatacga gtaaaatctt caaagctata agtcactata
     6841 ccatctgctg ggtctgctat gatgatttca tgcttagtga tcttgtgcac aacgacataa
     6901 tgcattaagc ctccttcctt aatcacatga gctattgctg gcaaaggaaa ctcacctaat
     6961 aatgcttctg gttcaccctt aaccccctta gcactaaatc ccaacttttc agctgcctct
     7021 aacatacctg ctacattagt tccttctgtg tccgtccctg ctgcttccct aattttagta
     7081 ataggtgtac tgagtccata ttgcttacaa actgttgcta agcatgctgc tccacagtct
     7141 gtcatatcgt attgcatgat acaataatat ttcgccatac cgcccctctt ttctaccccc
     7201 ggctatattt gtacacaaaa aaaagaaata ctaataaaat attataatat ttttattagt
     7261 atttccattc ttatttacag tatttcgatt aatctacaat accctaactt aactatatac
     7321 ttatacgtat taatcattta attatggaat aaatattgat ataaattctc tcatcacagc
     7381 gctacaatac gcaagtgcac cacctgaaat tttttgcttc tctctcttag ataattcttt
     7441 aaaatgctct accttattta cttctttaat ctttttcata tacttacctc ctcttagatt
     7501 attaatatta cccctagtat ctttagtata agttatttgt atttcacttc tattgtattt
     7561 gcttaaaatg tatgttttta atacctaagc tgttacacta taactaatag gtatatctat
     7621 ctctaagtaa aactcctctt ctttacttat aatattgata ttaccattat ttttttgcac
     7681 actctttcta atattagcca agccaaaacc atgattaata ctatcttttt tgttagtagg
     7741 aatttctttc ttatgatcta tctccactct accattagca gtatttttta tgttgtagaa
     7801 caaataacct cgatcacaga ctgctttcat ttgaattctt ttgactctac tagcctccac
     7861 tctttcacaa gcctctatag cattatctaa actattagca aatataacac ataagtccat
     7921 gtcatctagg cctaactgct tactaaattt tacttcgtat tccatttgaa tatttttctc
     7981 cttagctatt tgcaacttat catttaaaat agcatctaca atagaatgtc cagtatgaac
     8041 catataatct agtcgctctg ttgtattctc catttctgca atatattgct ctagcttatg
     8101 taattctcct tgctgtgcta aactcctaat aataatcata tgattacgca tatcatgctt
     8161 gatagccctt gtttctttat taatctcttc taacttatga taatatttaa attgcctctc
     8221 tagctgctca ctcatacatt cattactcca tttataataa agcttattca tttcttcatt
     8281 aattcctaaa attaatataa ttatacaaat aaagaatatt aggatataag tccctacact
     8341 aatactttgc aagagctcaa tatcaccaaa gtaagctgca tcacatataa aaagtgtata
     8401 cattgcagta atagtaagta atataatggc taaagcttgc cttctagtaa ctgttttata
     8461 ctgcccactt gctttataaa tgatattact ttgtttacct aaaaaccata aaatagtacc
     8521 ttctaaagca catcttatct ctgttactat ttgattctca agccaagtat gtccatagtg
     8581 ttctacaata tagtcaatca acatccaatc tagggtacct ataccatata tcaccgcaag
     8641 gcctaaaaaa ttgacccaaa ccttatttaa aaaggtcccc tcaaaaagaa aattagcaaa
     8701 gcaaactcca aagaataata ctcctgatat aactttttga tgggtaatga acataaatgc
     8761 acatattacg ccaacataaa gtaaatactt tataattctt tttctagtta gttgagcttt
     8821 atccaaaaaa gcatttaaac acatagattg catcacaaaa cagtttatta aacctgctag
     8881 taagtctaat ttatccaagt cggtgtgcct cctttaaata gagacgaaag ctttctttga
     8941 aagctttaat ccttagacga ctcatataca ccacatctcc attttgcatg gttacagttg
     9001 cttgatcata ttccttcaca tacgccaaat taatcaggta agatttatga attctaaaaa
     9061 atcccttgtc agccacgaac ttgtctactt cattaatttt attatctatg atgtattcct
     9121 tctgacttgt aactgcacgt aattttctat ctactgtttc aaaataaata atatccgcaa
     9181 atggaatttg aaagaatctc tgtccttgat taagagtgat tagttttgaa agcttttctt
     9241 tccttttctt taaaattaag tcaaaggttt taaagagctg ttctttttgt atcggtttta
     9301 ataaatatct aagtgtgtta acttcaaaag cacaatgagc ttcttctgga tggctagttg
     9361 taaagatgat gtctgctttt aaatttttct gacgtatttt ctttgctaat gttatgccat
     9421 taatactgtt ttctatttca acgtctaagc aaaatacatc acactgttca tagttagctt
     9481 ttaagagttc ttcagctgaa gagaaatatt gtatttcata ttgctttaca cgacttttta
     9541 agtactcttc taaaagcgct tctaaatgtt tacggaagac ttcttcatca tcacacacaa
     9601 aaatcctgaa cattctatcc tccccctaaa taattggtat acttacctaa ttattactct
     9661 ttttactctt agatattatc acattagttt aagtttttta actattttta ttatttttta
     9721 aaactttaca aaaatttcac ctatttttaa tctgtttgta acataaacta ctaactccaa
     9781 aaagcgatat attataccat ggaataatat atcgcttttt tgcaactact tgctctattc
     9841 tattttactt ttaattacaa cctattcgta tttctacacc tatggttcta caccagcaac
     9901 taaattacca tcatagtaaa cgcaaacctt gccagcattt ccgtaagaat agtcattagt
     9961 ttgatcataa ttactccagt tagattttgc tgttctagta gcaatttcta aagtagtacc
    10021 tgctgaaatc atttctgatg cattgatcgt tatttgaata taacagtctg ctcctgcttt
    10081 agtagcatcc attttgataa cttttccact tactttactt gtgtaaggac tataccatgg
    10141 tgctttattc atttgtgctg ctgcattatc acaccatacc gtttgtccct cactaccatc
    10201 agcagtatag tagtaacgga tttctaattt agataaatca atatcattac cactcttatg
    10261 tactaactta aagttatttg taagtgtgtt agtagatgct tgaccattgc ctgtattgcc
    10321 aacctctaat acaaagtcaa ctactggtac ttctactact tcaagctgta catatacttt
    10381 aacagcagtt gatgtagttg tttttccttt tgtagatgtt gctttagctg taaagctaat
    10441 aggtgttaat tgacccattt ctgtaactgt accttctgct acataagtag ctgtgtatac
    10501 gccatctact gcgctagtgc tttcagcgaa ttttttgcca tctgcataga attcaactaa
    10561 cttaatatcg tcttctaata catccgcagc aacacttact tctatttgct ttgttacctc
    10621 tgcaaaagtt tcttcattag caggtgaaac aatttctacc tctggtgctg ctatgacagg
    10681 aagttgtaca gatacattaa caggtttaga tattgttttg gtaccattcg ctgcaattgc
    10741 ttcagctgtt ataatatact cgcttaattc acctaactta ctagctgagc cagttggtaa
    10801 ataagatgct gcatatggtg ccactttact ttcacctact accttgccat ttacataaaa
    10861 tactactttt tgaatagtag acttctctat ttcagctgta gcattcatag taatggctgt
    10921 aatgccctta ctcatatcta tgcttgttcc atcaatagga gcggtaacag ctactattgg
    10981 tgctgctagt actggtaaaa caacagatac tttaacagct tcagaagtag tagatttgcc
    11041 attagctgcc gttgctttaa cagtcaagct ataatccttt gtagtaccta caactgtact
    11101 gtagtcactt ggtacaaaat tcatttcata aggcgccttt gtgctttctc caatcttagt
    11161 accgtctaca aaaaattcta cttttgaaat agtactttct tgtacctctg catttgcttt
    11221 aataacaact ggatttgctt ctgttacatc tttaaagata gttcctgcta ctggtgatgc
    11281 aatacttgtc gttggtgcat aaacctttgt agcccctgaa ggttcctgac caaatactaa
    11341 tttaccatta tcatataatg caaaatgatt tgcttttgct aagctatttg aacttgaact
    11401 tgctatatcc acaaatgatg ggctctttgt gtaatcccat tttcctgggg ctgcaattct
    11461 aaattgtaat tcgctcttat gttcactttg accacctgga taaattttag caccagttag
    11521 gtcaatttct acataataaa tgccgttttg tgcatcccaa ggttgtaagc tagatatttt
    11581 agcaccactt tgattgtaat tagctgaaat cttcatatca cttgctttat aacctgcagc
    11641 taatacatca ctaatatcca cgaaatatct ataagcaagc ttatccgtta ctcttgcagg
    11701 ccaagcactt ctgttataaa caactgcttt aatttctacg aaattaattg cattttgttt
    11761 gtcttgtgca ttaatacctg cttcaaggaa tatttcttcc ccaactttct ctatagcatt
    11821 tagatttgga ttgatagttc cgccgtagtc ttcatacatt tttgccatta aacctacaaa
    11881 tccagcattg taatcacatg ccacttcatt tgatacatag tctgaaatta catctgtata
    11941 tttatcattc ttatctggtc ctcctactaa agcgccaata agtacatgtc ttggctcata
    12001 tggttgtcct gataaattat tttcccatgc accatgagct gttctatgat gtggtttagt
    12061 aggtggattt actccaaaac caactacaaa actacgtcct gtgctaccaa gagcataatc
    12121 tgcttgagac ttagcgaagt tttgataggt ttgtgctctg tttgcatcag catcttcc
//
