LOCUS       NC_015275.1             9705 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_015275.1 Cellulosilyticum lentocellum DSM 5427, complete
            sequence.
ACCESSION   NC_015275
VERSION     NC_015275.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:12:07
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 165966
            Orig. end    :: 175671
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1527
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 427.6;
                     E-value: 1.1e-129)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_110"
                     /sec_met_domain="HMGL-like (E-value: 2.9e-85, bitscore:
                     284.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRKIYVLDTTLRDGEQVPGAKLNLNEKLEIARQLVKLKVDMMEV
                     GFPSSSKGDFEAVKAIGQIAGKDVMVTGLGRAVKSDIDAIYESLRGAANPMIHIVLGSS
                     NVHMEKKFSKSPTQVLEMGVEAVKYAKSLMPQVQYSLEDASRSDFEYMWKTIEAVVKAG
                     ATIINVPDTVGFAVPEEFGNLICKINDRLMNLNPNIILSVHCHNDTGLATANTLAAIRN
                     GANKVECTINGIGERAGNTSLEEVVMGIKLHPKYYRGETNINIEEIYKTSRMVSAIMGL
                     DVQVNKAITGENAFAHSSGIHQDGLLKSKEVYEIITPEEVGAPPMEIVLTARSGKHAFS
                     YVTKKLGYNIPEIIEPEVYKSFLTMADQKKEVYDSDVMTLLESYTEITNNKEIKLWQLK
                     EFQVTASSQMQVATVKLQKSEKMITRSESGEGAVDALYSAIIKAVDQSIDLMEYRIHNL
                     GRGKESLGKVVVQIKHKEKLYQGKAIEKDVMKASAIALVNAINKVNLESI"
     protocluster    1..9705
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[168581:170789](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2616..4823
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..9705
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9705
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     aSDomain        10..1503
                     /aSDomain="TIGR00973"
                     /aSTool="tigrfam"
                     /description="leuA_bact: 2-isopropylmalate synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_110_0004"
                     /evalue="3.60E-182"
                     /identifier="TIGR00973"
                     /label="ctg1_110"
                     /locus_tag="ctg1_110"
                     /protein_end="501"
                     /protein_start="3"
                     /score="604.2"
                     /tool="antismash"
                     /translation="KIYVLDTTLRDGEQVPGAKLNLNEKLEIARQLVKLKVDMMEVGFP
                     SSSKGDFEAVKAIGQIAGKDVMVTGLGRAVKSDIDAIYESLRGAANPMIHIVLGSSNVH
                     MEKKFSKSPTQVLEMGVEAVKYAKSLMPQVQYSLEDASRSDFEYMWKTIEAVVKAGATI
                     INVPDTVGFAVPEEFGNLICKINDRLMNLNPNIILSVHCHNDTGLATANTLAAIRNGAN
                     KVECTINGIGERAGNTSLEEVVMGIKLHPKYYRGETNINIEEIYKTSRMVSAIMGLDVQ
                     VNKAITGENAFAHSSGIHQDGLLKSKEVYEIITPEEVGAPPMEIVLTARSGKHAFSYVT
                     KKLGYNIPEIIEPEVYKSFLTMADQKKEVYDSDVMTLLESYTEITNNKEIKLWQLKEFQ
                     VTASSQMQVATVKLQKSEKMITRSESGEGAVDALYSAIIKAVDQSIDLMEYRIHNLGRG
                     KESLGKVVVQIKHKEKLYQGKAIEKDVMKASAIALVNAIN"
     PFAM_domain     13..825
                     /aSDomain="HMGL-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00682.21"
                     /description="HMGL-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_110_0012"
                     /evalue="2.60E-84"
                     /label="ctg1_110"
                     /locus_tag="ctg1_110"
                     /protein_end="275"
                     /protein_start="4"
                     /score="283.0"
                     /tool="antismash"
                     /translation="IYVLDTTLRDGEQVPGAKLNLNEKLEIARQLVKLKVDMMEVGFPS
                     SSKGDFEAVKAIGQIAGKDVMVTGLGRAVKSDIDAIYESLRGAANPMIHIVLGSSNVHM
                     EKKFSKSPTQVLEMGVEAVKYAKSLMPQVQYSLEDASRSDFEYMWKTIEAVVKAGATII
                     NVPDTVGFAVPEEFGNLICKINDRLMNLNPNIILSVHCHNDTGLATANTLAAIRNGANK
                     VECTINGIGERAGNTSLEEVVMGIKLHPKYYRGETNINIEEIYKTSRMV"
     PFAM_domain     1111..1509
                     /aSDomain="LeuA_dimer"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08502.12"
                     /description="LeuA allosteric (dimerisation) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_110_0013"
                     /evalue="1.40E-26"
                     /label="ctg1_110"
                     /locus_tag="ctg1_110"
                     /protein_end="503"
                     /protein_start="370"
                     /score="93.1"
                     /tool="antismash"
                     /translation="EVYDSDVMTLLESYTEITNNKEIKLWQLKEFQVTASSQMQVATVK
                     LQKSEKMITRSESGEGAVDALYSAIIKAVDQSIDLMEYRIHNLGRGKESLGKVVVQIKH
                     KEKLYQGKAIEKDVMKASAIALVNAINKV"
     CDS             1684..1872
                     /locus_tag="ctg1_111"
                     /transl_table=11
                     /translation="MKKVNEKEMRMIKGGYTYYVYCQACDWDYTYEYTFSFWYTIARDH
                     CETQLKNHLVNCPGIWG"
     CDS             2104..2247
                     /locus_tag="ctg1_112"
                     /transl_table=11
                     /translation="VGVYNLWKLGVFLKDKGYIGGHIAKELEKNNIMLRMIKRNNSKKI
                     LI"
     CDS             2616..4823
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 266.4; E-value:
                     8.8e-81)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_113"
                     /sec_met_domain="TIGR01193 (E-value: 6.9e-180, bitscore:
                     597.9, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.9e-36, bitscore:
                     121.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDMKKYIIKQHDERDCGAACLAMISYSYGLKYPLQRYREFSKT
                     DISGTNLYGLVDGATQIGLQAEALNGSLEDLEVAINGGEISFPFIIHTIESHYIVVFDI
                     KKNKVTIGDPSKGKVKYSKEEFIKIWSGYVITFKKTQEFKEGDYCQGNFARFFKLIGEQ
                     KSILISIFFLSLIISLIGIMGTFVFEAVIDNFLPSKDSLTKIVRGPINGILSFNLVFIV
                     LIVVYLIQAIMQLVRNYLLAIVSKKIDISLMLSYYRHLMNIPVSAVKGRLTGEYLARFS
                     DATTIRSAVSGATLTIMLDSTMVVFGGIILYFKSRLLFAISLIVISIYLIVILCYKKAI
                     KTINYRIMENNSKLQSYFKETIDGIETIKANHAEEIVTQNTTRRFNILINDVLKGSIIS
                     SSQDVLLRLVETIGIVVVLWVGFYMVLNDIITVGMLLTFYALQGYFISPIKNIIKLQPM
                     IQTAVVAAERLNDILDIGVERYDNEVEKLNIETIEYEGVSFRYSNNELTLRDINLKINE
                     GERIAIVGESGCGKTTLVKLLLEFYIPEQGNIKINGQDISNISLGDIRRNIAYVDQNTF
                     LFSDSIINNLKLGNPESTFEEIKEACRISKADKFINKTLLGYETYLDENGQNISGGQRQ
                     LLSIARSLVKGANIIVLDEATSNLDTITENNIGDTILDLSRELTLIIIAHKLSTIKECD
                     RIYVMKEGGIVEHGTHKELIDKKGVYYQMYIADNKIAICAN"
     PFAM_domain     2634..3038
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_113_0014"
                     /evalue="2.20E-35"
                     /label="ctg1_113"
                     /locus_tag="ctg1_113"
                     /protein_end="141"
                     /protein_start="6"
                     /score="121.4"
                     /tool="antismash"
                     /translation="KYIIKQHDERDCGAACLAMISYSYGLKYPLQRYREFSKTDISGTN
                     LYGLVDGATQIGLQAEALNGSLEDLEVAINGGEISFPFIIHTIESHYIVVFDIKKNKVT
                     IGDPSKGKVKYSKEEFIKIWSGYVITFKKTQ"
     aSDomain        2649..4787
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_113_0005"
                     /evalue="7.20E-180"
                     /identifier="TIGR01193"
                     /label="ctg1_113"
                     /locus_tag="ctg1_113"
                     /protein_end="724"
                     /protein_start="11"
                     /score="597.9"
                     /tool="antismash"
                     /translation="QHDERDCGAACLAMISYSYGLKYPLQRYREFSKTDISGTNLYGLV
                     DGATQIGLQAEALNGSLEDLEVAINGGEISFPFIIHTIESHYIVVFDIKKNKVTIGDPS
                     KGKVKYSKEEFIKIWSGYVITFKKTQEFKEGDYCQGNFARFFKLIGEQKSILISIFFLS
                     LIISLIGIMGTFVFEAVIDNFLPSKDSLTKIVRGPINGILSFNLVFIVLIVVYLIQAIM
                     QLVRNYLLAIVSKKIDISLMLSYYRHLMNIPVSAVKGRLTGEYLARFSDATTIRSAVSG
                     ATLTIMLDSTMVVFGGIILYFKSRLLFAISLIVISIYLIVILCYKKAIKTINYRIMENN
                     SKLQSYFKETIDGIETIKANHAEEIVTQNTTRRFNILINDVLKGSIISSSQDVLLRLVE
                     TIGIVVVLWVGFYMVLNDIITVGMLLTFYALQGYFISPIKNIIKLQPMIQTAVVAAERL
                     NDILDIGVERYDNEVEKLNIETIEYEGVSFRYSNNELTLRDINLKINEGERIAIVGESG
                     CGKTTLVKLLLEFYIPEQGNIKINGQDISNISLGDIRRNIAYVDQNTFLFSDSIINNLK
                     LGNPESTFEEIKEACRISKADKFINKTLLGYETYLDENGQNISGGQRQLLSIARSLVKG
                     ANIIVLDEATSNLDTITENNIGDTILDLSRELTLIIIAHKLSTIKECDRIYVMKEGGIV
                     EHGTHKELIDKKGVYYQMY"
     PFAM_domain     3117..3959
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_113_0015"
                     /evalue="3.10E-35"
                     /label="ctg1_113"
                     /locus_tag="ctg1_113"
                     /protein_end="448"
                     /protein_start="167"
                     /score="122.3"
                     /tool="antismash"
                     /translation="ISIFFLSLIISLIGIMGTFVFEAVIDNFLPSKDSLTKIVRGPING
                     ILSFNLVFIVLIVVYLIQAIMQLVRNYLLAIVSKKIDISLMLSYYRHLMNIPVSAVKGR
                     LTGEYLARFSDATTIRSAVSGATLTIMLDSTMVVFGGIILYFKSRLLFAISLIVISIYL
                     IVILCYKKAIKTINYRIMENNSKLQSYFKETIDGIETIKANHAEEIVTQNTTRRFNILI
                     NDVLKGSIISSSQDVLLRLVETIGIVVVLWVGFYMVLNDIITVGMLLTFYALQGYFISP
                     "
     PFAM_domain     4137..4586
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_113_0016"
                     /evalue="1.10E-33"
                     /label="ctg1_113"
                     /locus_tag="ctg1_113"
                     /protein_end="657"
                     /protein_start="507"
                     /score="116.7"
                     /tool="antismash"
                     /translation="LRDINLKINEGERIAIVGESGCGKTTLVKLLLEFYIPEQGNIKIN
                     GQDISNISLGDIRRNIAYVDQNTFLFSDSIINNLKLGNPESTFEEIKEACRISKADKFI
                     NKTLLGYETYLDENGQNISGGQRQLLSIARSLVKGANIIVLDEATS"
     CDS             complement(5370..5918)
                     /gene_functions="other (smcogs) SMCOG1238:transposase
                     (Score: 127.3; E-value: 1.3e-38)"
                     /gene_kind="other"
                     /locus_tag="ctg1_114"
                     /transl_table=11
                     /translation="MLLRLGFSYTKPTYSLAKANAEKQKTFKEDFEVLKGQQRIIPTFG
                     QHQGVKLLGVLNYETGHVYVQKEEHYDAEVFLQFLKKVLTIYPTGKIALVLDNARIHHA
                     KLIQPFLEKNKERLKLIFLPAYSPELNLIEGLWKWLKNTVIYNVFYKSVYEIRRAVQDF
                     IKYINFHTDEVIDRLCIEM"
     PFAM_domain     complement(5451..5819)
                     /aSDomain="DDE_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13358.8"
                     /description="DDE superfamily endonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_114_0018"
                     /evalue="1.30E-31"
                     /label="ctg1_114"
                     /locus_tag="ctg1_114"
                     /protein_end="156"
                     /protein_start="33"
                     /score="109.4"
                     /tool="antismash"
                     /translation="LKGQQRIIPTFGQHQGVKLLGVLNYETGHVYVQKEEHYDAEVFLQ
                     FLKKVLTIYPTGKIALVLDNARIHHAKLIQPFLEKNKERLKLIFLPAYSPELNLIEGLW
                     KWLKNTVIYNVFYKSVYEI"
     PFAM_domain     complement(5829..5918)
                     /aSDomain="HTH_33"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13592.8"
                     /description="Winged helix-turn helix"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_114_0017"
                     /evalue="9.80E-07"
                     /label="ctg1_114"
                     /locus_tag="ctg1_114"
                     /protein_end="30"
                     /protein_start="0"
                     /score="28.4"
                     /tool="antismash"
                     /translation="MLLRLGFSYTKPTYSLAKANAEKQKTFKED"
     CDS             complement(6119..6313)
                     /locus_tag="ctg1_115"
                     /transl_table=11
                     /translation="MTARLSELQRIQEAMNTTKSTRMQQRYQVILLHLKGYQNIQIADI
                     VGRCEIPSENTLIPIKSTV"
     CDS             8294..8707
                     /locus_tag="ctg1_116"
                     /transl_table=11
                     /translation="MNINSILGNIIDGVYNGPSINQREKIYNDINAEIVVIATVLPEKT
                     TIKLSEVSGFTEAKLQITGIIAGEVNKQEIIKVQEPYMESSYRGRACMIVEGGYEPVMV
                     DKEYIFYLNSIKEVNENGKVSYKIRKKIPLKNI"
     CDS             9001..9705
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 204.3; E-value: 3e-62)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_117"
                     /transl_table=11
                     /translation="MLGRLLIVEDDEQIADILREYLMNKGYEVNWASTGNEGLEDFKMK
                     MYDLLIVDIMLPGMDGYSLCQSIRWVSDVPILIISARNKELDKIKGLKIGADDYVTKPF
                     SLPEVEARIESLLRRYKRMNSSEEQEEIHHYEGGLSINFNRKQAYLNEEELNLTATEWA
                     LLTILAKNPQRPFTKKELYEHIWHEEDIESSNTITVHIKQLRNKLKEDSKNPKFIETAW
                     GIGYRFIGGRIQ"
     PFAM_domain     9016..9339
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_117_0019"
                     /evalue="3.50E-27"
                     /label="ctg1_117"
                     /locus_tag="ctg1_117"
                     /protein_end="113"
                     /protein_start="5"
                     /score="94.9"
                     /tool="antismash"
                     /translation="LIVEDDEQIADILREYLMNKGYEVNWASTGNEGLEDFKMKMYDLL
                     IVDIMLPGMDGYSLCQSIRWVSDVPILIISARNKELDKIKGLKIGADDYVTKPFSLPEV
                     EARI"
     PFAM_domain     9457..9684
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_117_0020"
                     /evalue="1.30E-25"
                     /label="ctg1_117"
                     /locus_tag="ctg1_117"
                     /protein_end="228"
                     /protein_start="152"
                     /score="89.4"
                     /tool="antismash"
                     /translation="EELNLTATEWALLTILAKNPQRPFTKKELYEHIWHEEDIESSNTI
                     TVHIKQLRNKLKEDSKNPKFIETAWGIGYRF"
ORIGIN
        1 atgtcaagaa aaatctatgt attagacacc actttaagag atggggaaca ggtaccggga
       61 gcaaagttga atttaaatga gaagttagag attgcaagac aattagtaaa attaaaggta
      121 gatatgatgg aggtaggttt tccatcctcc tcaaagggag attttgaggc tgttaaagct
      181 attggtcaaa tagcaggtaa agatgtgatg gtaacaggac ttgggagagc agtaaaatca
      241 gatattgatg ccatttatga aagtcttaga ggagcagcaa atccaatgat tcatattgta
      301 ctagggtctt cgaatgtgca tatggaaaag aaatttagta agtcacccac tcaagtacta
      361 gaaatgggcg tagaagcggt aaaatatgct aaaagtttga tgccacaggt acagtactct
      421 ttagaagatg ctagtaggtc tgacttcgaa tatatgtgga aaactataga ggctgtagtt
      481 aaggcaggag caactattat taatgttcct gatactgtgg gctttgctgt tccagaagag
      541 tttggcaatc tgatttgtaa aatcaatgac cgtttgatga atcttaaccc caatattatt
      601 ttgagtgtac actgccataa tgatacaggg cttgctacag ctaacacttt agcagctatt
      661 agaaatggtg caaacaaagt tgaatgtacc attaatggaa taggagagag agctggtaac
      721 acttctttag aagaagtcgt catggggatt aaacttcatc caaaatacta tagaggtgaa
      781 actaacatta atatagaaga gatttataaa acttcaagaa tggtaagtgc cattatggga
      841 ttagatgttc aagttaataa agcaattaca ggggaaaatg cttttgccca ttcttcaggt
      901 attcatcaag acggactact taaatcaaaa gaagtctatg aaattatcac tccagaagaa
      961 gtaggtgcac ctcctatgga gattgtatta accgcacgtt ctggtaagca tgcttttagc
     1021 tatgtgacta aaaagttagg ctataatata ccagaaataa tagagcctga agtttataaa
     1081 agtttcctta ctatggcaga tcaaaagaaa gaagtctacg atagcgatgt gatgactttg
     1141 ttagaaagct atactgaaat tactaataat aaagagataa aattatggca gcttaaggag
     1201 tttcaagtaa ctgcttcaag tcagatgcaa gttgccactg ttaagcttca aaagtcggag
     1261 aaaatgatta caagaagtga aagcggagaa ggcgctgtag atgcacttta tagtgctatt
     1321 ataaaagcag tagatcaaag catagattta atggaatatc gcatccataa tctggggaga
     1381 ggtaaagaaa gtcttggaaa agtggtggta cagattaaac acaaggaaaa actttaccaa
     1441 gggaaagcaa ttgaaaaaga tgtaatgaaa gcaagtgcta ttgcccttgt taatgcgatt
     1501 aataaagtta atttagagag tatttaaaag ttgctaatta tatagttttt aaattctaaa
     1561 taaaaagaat aataaaaact ttataaataa ttaaatttat gatatggtaa gaatatatgt
     1621 gctaagactt agcctatata tttttattaa aaacataata ttaatatgga gggaggaaga
     1681 ataatgaaaa aagtaaatga aaaagaaatg agaatgatta aagggggata tacatattat
     1741 gtatattgcc aagcttgtga ttgggattat acatatgagt acacattttc attttggtat
     1801 acaattgcaa gagatcactg tgaaactcag ttgaaaaatc atttagtgaa ttgccctgga
     1861 atttggggct aaaagtaaaa tattggaggc aattatggtt atgaaaaaca aactatagtt
     1921 gtctctatat ttatctagaa ttatttagtt gatttgttat tttacttgat tctataaaag
     1981 agtagcagaa atatttttgc ataaatgtaa attttgatta gaggatacat aatttagtta
     2041 ttttgacaca taaattgccg acagtgaatc tatagcagag tataatcacg atggagaaat
     2101 actgtgggtg tttataactt atggaaatta ggggtttttc ttaaagataa aggatatata
     2161 ggtggtcata tagctaaaga attagagaaa aataatatta tgcttcgtat gattaagcga
     2221 aataatagca aaaaaattct tatctgaatg caataagtaa ttagattact agagatagga
     2281 atcatataga aactgtattt tttcaattaa tgattaatct catattaatc gcctttaaat
     2341 tagaattaac agctagattt taaaatgaaa tattagttaa caatatccga tgctttatga
     2401 ataagtgtta gacaatgccc ctataaataa gataggacag attcaacatc tgattttgag
     2461 agaaataaac tttaatgaaa ataaaagacg agtattttgg tataaatatt agcgtttact
     2521 caatataatt aaaattatta gttgatatat gttattaata caaaacctag ggataggtaa
     2581 taaggaattt agatttaaaa tcaaaatata gaaagatgaa gatagatatg aaaaaatata
     2641 ttattaagca gcatgatgag agggactgtg gtgcagcttg tcttgcaatg atatcttatt
     2701 cttatggatt aaaataccct cttcagagat acagagaatt tagtaaaaca gatataagtg
     2761 gaacgaactt atatggttta gttgatggag caacacaaat tggattacaa gcagaagctt
     2821 taaatggaag cttagaagat ttagaggtgg ctattaatgg aggagaaatt agttttccat
     2881 ttattattca tacaatagaa tcgcattata tagttgtttt tgatatcaaa aaaaataaag
     2941 ttaccatagg tgatccatct aaaggaaagg ttaagtattc taaagaagaa tttataaaga
     3001 tttggtcagg gtatgtgatt actttcaaaa aaacgcaaga atttaaagaa ggagattatt
     3061 gccaaggtaa ttttgccaga ttctttaaac taataggtga acagaagagt atattgataa
     3121 gtattttttt cttatctttg attatttctt tgattgggat aatggggaca tttgtttttg
     3181 aagcagttat agataatttc ctacctagta aggattctct aacaaaaata gtaagagggc
     3241 ctattaatgg tattttaagt tttaatttag tttttattgt tctaattgta gtgtatttaa
     3301 ttcaagcaat tatgcaatta gtaagaaatt atttactagc tattgtttca aaaaaaatag
     3361 atatttcatt aatgctttca tactataggc atttaatgaa tattcctgtt tcggctgtaa
     3421 aaggcaggct aactggtgaa tatttagcac gattttctga tgctacaaca atacgttcag
     3481 cggtttcggg agctacatta acaattatgt tagattctac tatggttgta tttggaggta
     3541 taattctata ttttaagagt aggttattat ttgctatatc attaatagta ataagtatat
     3601 atttaatagt aatcttatgt tataaaaaag ctataaaaac tataaattat agaataatgg
     3661 aaaataattc aaaattacaa tcatatttta aagaaactat tgatggaata gagactatta
     3721 aagctaacca tgcagaggaa atagtgacgc agaatacaac tcgaagattt aatatattaa
     3781 ttaacgatgt gctaaaagga agtattatta gctcatccca agatgtgtta cttagattag
     3841 ttgaaacaat tggtatagtg gttgttttat gggttggttt ctatatggtt ttaaatgata
     3901 taatcacagt ggggatgtta cttacttttt atgcattaca agggtatttt atatcaccta
     3961 ttaaaaatat tataaaattg caacctatga tacagacagc agttgttgca gcagaaaggc
     4021 taaatgatat attagacata ggagtagaac gctatgataa tgaagtggag aaacttaata
     4081 tagagaccat agaatatgaa ggtgttagct ttcgttattc gaataatgaa ttaacattaa
     4141 gggacattaa tctaaagata aatgaaggtg agagaatagc aatagtaggt gagagcggtt
     4201 gtggtaaaac tacgttggta aaattgctgc ttgaattcta tattccagag caaggaaaca
     4261 taaaaattaa tggacaagat attagcaata taagtttggg cgatataaga agaaatatag
     4321 catatgttga tcaaaataca tttttatttt cggatagcat aataaacaat ttaaaactag
     4381 gtaatccaga atcgacattt gaggaaatca aagaagcatg tagaataagt aaagctgata
     4441 agtttataaa taaaacacta ttgggctatg aaacgtatct tgatgaaaat ggtcagaata
     4501 tttcgggagg acaaagacaa cttttgtcaa ttgccagatc tttagtaaaa ggagcgaata
     4561 ttatagttct tgatgaagct actagcaatc ttgatacaat tacagaaaat aatatagggg
     4621 ataccatcct agatttaagt agagagttaa ctcttattat tatagcacat aaactaagta
     4681 cgataaaaga atgcgatagg atatacgtaa tgaaagaagg gggaattgtt gaacatggaa
     4741 ctcataagga attaatagat aagaaggggg tatattatca aatgtatata gcggataata
     4801 aaatagccat atgtgctaat tagtatttcc taataagtag aatatatatg ataataggat
     4861 aagttattat agtaattagc atcaagttta tttgtggaaa tattagattt aagttacttg
     4921 ttagagtttt gttgggaaat ttattcaaaa tatataatgt tatcgcctgg agtatacttt
     4981 aaaatttagc atttaggcca cttactgaga ttactaatac ttcggttatg cacaattgtt
     5041 ttgttaccag agaaaaggtg gtctcaaatt tttgtttatt ggttttctta attctttagg
     5101 ataaggagtt ttactattgg tgtattttga aattaatagt gtaatatctt tttcagcttg
     5161 taatttttga ggtaatacat tacggatata tccactattt cctaaagaat atgattcaat
     5221 aagaattagg tataagttta catagaatat cttaatcagt tacgttggga gcaataattt
     5281 taatatctat aacataggta tctaaagtga ttaaagcgtg tagttttaag tcataataat
     5341 tttttattat atataaacag attgtaaaat tacatttcaa tgcatagtct atctataact
     5401 tcatctgtat ggaaatttat gtattttata aaatcttgca ctgctctacg aatctcatat
     5461 acactcttat aaaatacgtt atatataact gtattcttta gccatttcca taaaccttca
     5521 ataagattca attcaggact atatgctggt aagaatataa gttttaaccg ttctttattc
     5581 ttttctaaaa atggttgtat gagcttagca tgatgaattc gtgcattatc aagcactaag
     5641 gcgattttac ctgttgggta aatagttaat acctttttta gaaactgtaa aaatacttct
     5701 gcatcgtagt gttcttcctt ttgaacatat acatgacctg tctcataatt caagacacca
     5761 agtaatttta cgccttgatg ttgtccaaaa gtaggaataa tacgttgctg cccttttaaa
     5821 acctcaaaat cttctttaaa ggtcttttgc ttctcagcat ttgctttagc taaagaataa
     5881 gttggtttgg tataactaaa tcctaaacgc aataacatat cacgcatacc accattggtg
     5941 taagtaacat caaactgttc tttcacccat aaacaaacaa gcttagagtt ccatgactta
     6001 taaggagata agcctacctg atcaggtgtt ttagtcgata ctgtctgaat taaaatagct
     6061 tcttgttctg gagtaagctt tggttttgca ccttcacgag gtttaataat tagaccagct
     6121 ataccgtgct ttttataggt attaacgtat tttccgacgg tatctcacaa cgtcctacaa
     6181 tatcggcaat ctgaatgttt tgatatcctt ttaggtgtaa taagataact tgatatcttt
     6241 gttgcatacg tgtagattta gtagtattca tagcctcttg aatacgttgt aattctgata
     6301 agcgtgcagt catagtgtaa agtcccccga atttaagaat atatacatag attgtcaaaa
     6361 tttatgtact ttctcattag gggattaatg gatgaaatct agtaatctgt ttctatatag
     6421 ataaatagta tttgaattct aacatgtatt tacctatttt gtttttagat aacaagatat
     6481 cacatgatta gggattattc tatttataaa tttaactaat ataactcatc aaaatagtat
     6541 ttctagattt aagctttttt agaaagtgta ttctttcaag gtcattagaa gtagattagt
     6601 atggatgaat gtagtagagt taattgtgct atatataatg aagacatagt ataaataaca
     6661 tattttatgc cgatagaatt gaagcttaag agaagtattc taatgtaaaa aatacttgag
     6721 ttaaatatat aaagtagagg ataaaaaaaa taagaataca tatactaagg ttattgatat
     6781 tcctttaata cgtcaaattt tagggggcta aggataaaag tgaaatttcc tgttaaaaaa
     6841 aataaaaaaa gagttgacgt atgtaacaat atggtgtaac atagtaaaag tcagcggcga
     6901 ggaaacaaag aaacaaacgc agcaaataat aatgaggccc attggtcaag cggtcaagac
     6961 accgcccttt cacggcggta acacgagttc gattctcgta tgggtcattg ttagtttatc
     7021 taacaaaagc cggggtgtgg ctcagtttgg ctagagcgcc tgatttgggt tcaggaggcc
     7081 gcaggttcga gtcctgtcac cccgattatc taaaacgact tccttagaag taggctttta
     7141 gatctaatgt gggtcactag ctcagtcggt agagcacttg acttttaatc aagttgtccc
     7201 gggttcgatt cccgggtggc tcactttttt atatggccca gtggtacagt tggttagcac
     7261 gccgccctgt cacggcggag gtcgagggtt cgagtccctt ctgggtcgtt taagtgattt
     7321 ttaattgctt aattttttaa caagtggtaa tattaccatt ataaggtcgc ttagctcagc
     7381 tgggagagca cctgccttac aagcaggggg tcataggttc gagccctata gcgaccatta
     7441 atgtgcccga gtggcggaac tggcagacgc acaggactta aaatcctgcg agctaaccct
     7501 cgtaccggtt cgattccggt ctcgggcata tttaaataat taaagtgtga ttatataatt
     7561 ggattgttca aaagctggta gatgaaggcc gatgtggctc aattctagcg cagataccaa
     7621 aggtatcaag aggattgcta attggtgcac acgtatagaa gactaaccta gccaaggact
     7681 agtgtcgtca atgatttcaa ttatattatg aatatgccga cgtggctcaa ttggcagagc
     7741 agctgacttg taatcagcag gttatcggtt cgagtccgat cgtcggcttt acaaaatgaa
     7801 tattttgtat ctatggaggg attcccgagc ggccaaaggg ggcagactgt aaatctgttg
     7861 cgatagcttc gaaggttcga atccttctcc ctccataacc tatatcgcgg gatggagcag
     7921 ctaggtagct cgtcgggctc ataacccgaa ggtcataggt tcaaatcctg ttcccgctac
     7981 cataagatta gcgcgaactt ggcgctaata catgcccaga tagctcagtc ggtagagcag
     8041 aggactgaaa atcctcgtgt cgctggttcg attccggctc tgggcattta agaaaaggta
     8101 ctctttaact aagaaagctt agttgggggg tattttttta ttgttaaatt tagatttcaa
     8161 aatatttcgt ttagttgata gtaatgttac agaatgaata tttaatagtc agccttgata
     8221 tgagtgtata tacttgataa tgtgaagctt caaataaaaa atctatccac tcaagttaag
     8281 gaggtcatac tatatgaata taaatagcat actaggaaac ataatagatg gcgtttataa
     8341 cggaccttct attaaccaaa gagaaaaaat atataatgat attaatgcag aaatagttgt
     8401 aatagcaaca gtattaccag aaaaaacaac tattaaactt agcgaagtat ctggatttac
     8461 agaagcaaaa ttacaaatca caggtattat agctggagaa gtaaataaac aggaaattat
     8521 caaagtacaa gaaccttata tggaaagtag ctatagaggt agagcttgta tgattgttga
     8581 aggtggttat gaacctgtaa tggttgataa agaatacatt ttttatctta atagcataaa
     8641 agaagtaaat gaaaatggta aagtgagcta taagattaga aaaaagatcc ccctaaaaaa
     8701 tatttaaata aagcttgttg taaaaaagga ctgttacaat aaacagtcct ttttgcatgc
     8761 aaatttatgt agtgtaaaat tatcaagggg tttcatgaaa tcttaatagt aaaaagtatt
     8821 taataaataa ttatagtgaa catatagact atatcttttg ataaatagat tttaagcatt
     8881 ataatagaac atagtaggtg tatataaata aaatatttat aaacaatttt aaactaaggt
     8941 aattacggta tatgataaaa gtagaaaatg gagaatgggc atagagaggg tgagatatag
     9001 atgcttggac gtttattaat agtagaagac gatgagcaaa ttgcagatat tttaagagaa
     9061 tatctaatga ataaaggcta tgaggtgaac tgggcttcta cagggaatga aggtttagaa
     9121 gattttaaaa tgaaaatgta tgatcttctt attgtagata ttatgctgcc tggaatggat
     9181 ggctatagcc tttgtcaaag tataaggtgg gttagtgatg tccccatctt aattattagt
     9241 gctagaaata aagaactaga taagattaaa gggctaaaaa ttggagcaga tgattatgtg
     9301 acaaaaccct ttagtttacc tgaagtagaa gctcgaattg aatcactgct aagacgctat
     9361 aaacgtatga atagcagtga ggaacaggaa gaaattcatc attatgaagg tggattaagt
     9421 atcaatttta atcgtaagca agcttattta aatgaagaag aattaaattt aacagcaaca
     9481 gagtgggcgc tattaaccat cttagcaaaa aatcctcagc gaccttttac taaaaaagaa
     9541 ctttatgaac atatatggca cgaagaagat attgaaagca gtaatacgat taccgtacat
     9601 ataaaacagc tacgaaacaa gctaaaagaa gatagtaaaa atcctaaatt tatcgaaaca
     9661 gcgtggggca ttggctatag gtttatagga ggcaggattc agtga
//
