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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7

### Identified secondary metabolite regions using strictness 'relaxed'

NC_015275.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | RiPP-like | 118,525 | 130,338 |
Region 2 | RiPP-like | 165,967 | 175,671 |
Region 3 | RRE-containing | 541,247 | 557,378 |
Region 4 | cyclic-lactone-autoinducer | 2,083,580 | 2,104,313 |
Region 5 | ranthipeptide | 2,793,198 | 2,814,809 |
Region 6 | RiPP-like | 3,992,584 | 4,004,761 |
Region 7 | NRPS | 4,245,139 | 4,291,630 |

NC_015275.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 118,525 - 130,338 nt. (total: 11,814 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.24 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.22 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.22 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.21 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000484.1 |  | 0.20 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001733.1 |  | 0.19 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.57 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.55 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.55 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.54 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.53 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000484.1 |  | 0.53 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000617.1 |  | 0.52 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001733.1 |  | 0.51 | RiPP | PcpA | Pleurocapsa sp. PCC 7327
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_015275.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 165,967 - 175,671 nt. (total: 9,705 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000795.1 |  | 0.25 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000617.1 |  | 0.19 | RiPP | coagulin | Bacillus coagulans
BGC0000904.1 |  | 0.16 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001863.1 |  | 0.16 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001862.1 |  | 0.16 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.16 | RiPP | pallidocin | Aeribacillus pallidus
BGC0000928.1 |  | 0.15 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.15 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000516.1 |  | 0.15 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000802.1 |  | 0.15 | Saccharide | succinoglycan | Sinorhizobium meliloti

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000795.1 |  | 0.58 | Saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000617.1 |  | 0.51 | RiPP | coagulin | Bacillus coagulans
BGC0000904.1 |  | 0.47 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001863.1 |  | 0.46 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001862.1 |  | 0.46 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.46 | RiPP | pallidocin | Aeribacillus pallidus
BGC0000928.1 |  | 0.45 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.45 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000516.1 |  | 0.45 | RiPP | geobacillin II | Geobacillus thermodenitrificans
BGC0000802.1 |  | 0.45 | Saccharide | succinoglycan | Sinorhizobium meliloti

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_015275.1 - Region 3 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 541,247 - 557,378 nt. (total: 16,132 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001496.1 |  | 0.18 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001554.1 |  | 0.18 | Other | coenzyme F430 | Methanosarcina barkeri str. Fusaro
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.16 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001120.1 |  | 0.16 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000558.1 |  | 0.16 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000575.1 |  | 0.16 | RiPP | lariatin | Rhodococcus jostii
BGC0000496.1 |  | 0.15 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001634.1 |  | 0.15 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000551.1 |  | 0.15 | RiPP | SapB | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001496.1 |  | 0.50 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001554.1 |  | 0.49 | Other | coenzyme F430 | Methanosarcina barkeri str. Fusaro
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000513.1 |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001120.1 |  | 0.46 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000558.1 |  | 0.46 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000575.1 |  | 0.46 | RiPP | lariatin | Rhodococcus jostii
BGC0000496.1 |  | 0.46 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001634.1 |  | 0.46 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000551.1 |  | 0.45 | RiPP | SapB | Streptomyces coelicolor A3(2)

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_015275.1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,083,580 - 2,104,313 nt. (total: 20,734 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000361.1 |  | 0.05 | NRP | gliotoxin, bisdethiobis(methylthio)gliotoxin | Aspergillus fumigatus Af293
BGC0001283.1 |  | 0.05 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0001379.1 |  | 0.04 | NRP | BD-12 | Streptomyces luteocolor
BGC0001114.1 |  | 0.03 | NRP, Polyketide | thailanstatin A | Burkholderia thailandensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000361.1 |  | 0.23 | NRP | gliotoxin, bisdethiobis(methylthio)gliotoxin | Aspergillus fumigatus Af293
BGC0001283.1 |  | 0.21 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0001379.1 |  | 0.17 | NRP | BD-12 | Streptomyces luteocolor
BGC0001114.1 |  | 0.16 | NRP, Polyketide | thailanstatin A | Burkholderia thailandensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_015275.1 - Region 5 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,793,198 - 2,814,809 nt. (total: 21,612 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.18 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.17 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000517.1 |  | 0.16 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.1 |  | 0.16 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0000617.1 |  | 0.16 | RiPP | coagulin | Bacillus coagulans
BGC0000488.1 |  | 0.16 | RiPP | circularin A | Clostridium beijerinckii
BGC0000500.1 |  | 0.16 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000542.1 |  | 0.16 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000521.1 |  | 0.16 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0001229.1 |  | 0.16 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.50 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000519.1 |  | 0.48 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000517.1 |  | 0.47 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.1 |  | 0.47 | RiPP | SmbA, SmbB | Streptococcus mutans
BGC0000617.1 |  | 0.46 | RiPP | coagulin | Bacillus coagulans
BGC0000488.1 |  | 0.46 | RiPP | circularin A | Clostridium beijerinckii
BGC0000500.1 |  | 0.46 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000542.1 |  | 0.46 | RiPP | paenicidin B | Paenibacillus terrae
BGC0000521.1 |  | 0.46 | RiPP | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0001229.1 |  | 0.46 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_015275.1 - Region 6 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,992,584 - 4,004,761 nt. (total: 12,178 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.24 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000624.1 |  | 0.17 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001862.1 |  | 0.16 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.16 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.16 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.16 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000494.1 |  | 0.15 | RiPP | uberolysin | Streptococcus uberis
BGC0001928.1 |  | 0.15 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.1 |  | 0.57 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000617.1 |  | 0.52 | RiPP | coagulin | Bacillus coagulans
BGC0000624.1 |  | 0.48 | RiPP | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001862.1 |  | 0.47 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.47 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.47 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.47 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000494.1 |  | 0.46 | RiPP | uberolysin | Streptococcus uberis
BGC0001928.1 |  | 0.45 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_015275.1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,245,139 - 4,291,630 nt. (total: 46,492 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.1 |  | 0.31 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000900.1 |  | 0.30 | Other | ferrichrome | Aspergillus oryzae
BGC0001479.1 |  | 0.28 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000410.1 |  | 0.27 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000979.1 |  | 0.26 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.26 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000343.1 |  | 0.25 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001699.1 |  | 0.25 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001609.1 |  | 0.24 | NRP | gliovirin | Trichoderma virens Gv29-8

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.1 |  | 0.64 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000900.1 |  | 0.64 | Other | ferrichrome | Aspergillus oryzae
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000410.1 |  | 0.61 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000979.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000343.1 |  | 0.58 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001699.1 |  | 0.58 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001609.1 |  | 0.58 | NRP | gliovirin | Trichoderma virens Gv29-8

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 4245138 - 4291630:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (phe - tyr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3864: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (10..391): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      aFQaLGlAiK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      60% (weak)
ctg1_3866: phe - tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (197..584): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      phe, trp
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DqWgeGtINK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1226..1620): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGavcAEVAK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      70% (weak)