LOCUS       c00060_NZ_JHYD..        4656 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JHYD01000072.1 Ruminiclostridium cellobioparum DSM 1351 = ATCC
            15832 T344DRAFT_scaffold00060.60_C, whole genome shotgun sequence.
ACCESSION   NZ_JHYD01000072
VERSION     NZ_JHYD01000072
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:33:25
            Original ID  :: NZ_JHYD01000072.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4656
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4656
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[2:1184](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3..1184)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..4656
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4656
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS             complement(3..1184)
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     55.5; E-value: 9.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_1"
                     /sec_met_domain="Condensation (E-value: 6.8e-14, bitscore:
                     39.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-30, bitscore:
                     94.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKAGLIMNRIQENLLLNSEEFLQQKKYWLDRLSGYYPSSNLFMK
                     TRAADYGNKRPIKVKFSYPDELSESLIMLSKQSDLSLYLILLMALKCLIYKYTGSNDII
                     VCSPVYSDYCSEYTVNDVVLIRDEIREEKTLRECILDTGKSALKAYENQDYPFKNILNI
                     FDDFQEMNPFRNINVMCMLNNIHRQIDIENTDYGLVFAFDRNGRTVELELSCTDGIFNE
                     RMLNQLVSALENVLNNIITDVNITIHDAAVISKEERNYIIHQFNSSSHEYPEECCIYQL
                     FEEQMERTPDNIAIEAGGRYLTYRELNEKANRLARVLREKGVKRDSIVAIMADQSVEFV
                     VAVLGVLKAGGAYLPIDMEYPEERIRYMLEDSGTVIVLKDSEAITALDREQGTL"
     PFAM_domain     complement(12..341)
                     /aSDomain="AMP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00501.30"
                     /description="AMP-binding enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg60_1_0002"
                     /evalue="4.00E-30"
                     /label="ctg60_1"
                     /locus_tag="ctg60_1"
                     /protein_end="391"
                     /protein_start="281"
                     /score="104.9"
                     /tool="antismash"
                     /translation="FEEQMERTPDNIAIEAGGRYLTYRELNEKANRLARVLREKGVKRD
                     SIVAIMADQSVEFVVAVLGVLKAGGAYLPIDMEYPEERIRYMLEDSGTVIVLKDSEAIT
                     ALDREQ"
     PFAM_domain     complement(408..1139)
                     /aSDomain="Condensation"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00668.22"
                     /description="Condensation domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg60_1_0001"
                     /evalue="1.20E-16"
                     /label="ctg60_1"
                     /locus_tag="ctg60_1"
                     /protein_end="259"
                     /protein_start="15"
                     /score="60.6"
                     /tool="antismash"
                     /translation="LLNSEEFLQQKKYWLDRLSGYYPSSNLFMKTRAADYGNKRPIKVK
                     FSYPDELSESLIMLSKQSDLSLYLILLMALKCLIYKYTGSNDIIVCSPVYSDYCSEYTV
                     NDVVLIRDEIREEKTLRECILDTGKSALKAYENQDYPFKNILNIFDDFQEMNPFRNINV
                     MCMLNNIHRQIDIENTDYGLVFAFDRNGRTVELELSCTDGIFNERMLNQLVSALENVLN
                     NIITDVNITIHDAAVISKEERN"
     CDS             complement(1211..2818)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 297.7; E-value: 2.4e-90)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_2"
                     /sec_met_domain="PF04055 (E-value: 1.5e-25, bitscore: 78.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQSIDCLIIGHNQMKFCDYEGMVGSMGKESEPYQDLNLNFVRYN
                     SEAITAAETFNTFYKRAGNNKDIINLGELFSATIAYLGTYIKRRGFTFDYVNSFQDEKE
                     ELAKKLRENNVLTIAITTTLYVSSYPISEIISFVRQYNTTAKIIVGGPFVSTNARTQNE
                     VTMEYILCSLDADFYINSSQGEFALVQIINAVKNGLQFNQISNIYFKQKSGYIRNNIEI
                     ENNILAENMVDWSLFGDRVGRFATIRTAISCPFSCSFCGFPQHAGKYQTVDVETIEKEW
                     RALDSIGTVKSIYIIDDTFNVPRDRFKDILKMMIKNRFSFKWHSYFRCQFADEEIISLM
                     KESGCEGVFLGIESGSQEILNNMSKASTIEKYREGMKLLREYGIIINASFIIGFPGETY
                     KTVQETVRFIEDTRPDFYRAQLWYCEPITPIWKEKEKYGIKGSQFKWSHKTMDSKTGSK
                     LVNEVFLSVKNSIWMPQYNFDSASIFPLMQNGININQIKEFMSCFQEGIAEKLKSPNQK
                     NISLELEKRMEAVFKAAK"
     aSDomain        complement(1304..2806)
                     /aSDomain="TIGR04479"
                     /aSTool="tigrfam"
                     /description="bcpD_PhpK_rSAM: radical SAM
                     P-methyltransferase, PhpK family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg60_2_0001"
                     /evalue="7.40E-198"
                     /identifier="TIGR04479"
                     /label="ctg60_2"
                     /locus_tag="ctg60_2"
                     /protein_end="505"
                     /protein_start="4"
                     /score="655.9"
                     /tool="antismash"
                     /translation="IDCLIIGHNQMKFCDYEGMVGSMGKESEPYQDLNLNFVRYNSEAI
                     TAAETFNTFYKRAGNNKDIINLGELFSATIAYLGTYIKRRGFTFDYVNSFQDEKEELAK
                     KLRENNVLTIAITTTLYVSSYPISEIISFVRQYNTTAKIIVGGPFVSTNARTQNEVTME
                     YILCSLDADFYINSSQGEFALVQIINAVKNGLQFNQISNIYFKQKSGYIRNNIEIENNI
                     LAENMVDWSLFGDRVGRFATIRTAISCPFSCSFCGFPQHAGKYQTVDVETIEKEWRALD
                     SIGTVKSIYIIDDTFNVPRDRFKDILKMMIKNRFSFKWHSYFRCQFADEEIISLMKESG
                     CEGVFLGIESGSQEILNNMSKASTIEKYREGMKLLREYGIIINASFIIGFPGETYKTVQ
                     ETVRFIEDTRPDFYRAQLWYCEPITPIWKEKEKYGIKGSQFKWSHKTMDSKTGSKLVNE
                     VFLSVKNSIWMPQYNFDSASIFPLMQNGININQIKEFMSCFQE"
     PFAM_domain     complement(1592..2065)
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg60_2_0003"
                     /evalue="1.10E-21"
                     /label="ctg60_2"
                     /locus_tag="ctg60_2"
                     /protein_end="409"
                     /protein_start="251"
                     /score="78.0"
                     /tool="antismash"
                     /translation="SCPFSCSFCGFPQHAGKYQTVDVETIEKEWRALDSIGTVKSIYII
                     DDTFNVPRDRFKDILKMMIKNRFSFKWHSYFRCQFADEEIISLMKESGCEGVFLGIESG
                     SQEILNNMSKASTIEKYREGMKLLREYGIIINASFIIGFPGETYKTVQETVRFI"
     CDS             complement(2838..4655)
                     /NRPS_PKS="Domain: PCP (64-133). E-value: 1.8e-26. Score:
                     84.0. Matches aSDomain: nrpspksdomains_ctg60_3_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (147-432). E-value:
                     9.4e-95. Score: 308.9. Matches aSDomain:
                     nrpspksdomains_ctg60_3_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     313.2; E-value: 5.9e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_3"
                     /sec_met_domain="Condensation (E-value: 2.5e-84, bitscore:
                     270.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.1e-16, bitscore:
                     48.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GEPEENEIKRRLEKELPVYMVPSYIVKVERIPMTTNGKVDAKALP
                     DPKKGRGMKEEYIGPRDRIEEKLAEIWLQVLNLERVGIEDDFFGLGGHSLKATFLVNRI
                     HKELNAELPLGRLFETPTIAGLAEYIRDAEKKIYATIEPVEEKEYYPVSSAQKRMYITS
                     RFDGIGIGYNTPMAVIAEGNIDSEKFEEAVKALIRRHEVFRTSFEVVGDEVVQRIHKEL
                     DFSIEYLEVSEEETDNIVKKFIKPFDLGIAPLLRVGLIKQNKNKYVIIWDMHHIITDGV
                     SLGLLLKEFTAFYEGRVVPNLRLQYKDFAYWQNTLLSSGAIDKQKKYWEDRFKDGVPIL
                     NMPTDFQRPGVYSFEGEVVNFELEERLTSKLHELAAETTNTMQILLLAIFNILLYKYTG
                     QEDIVVGTATAGRQHADLENLIGMFVNMLALRNYPKGDKTYREFLQEVKEFSLEAYQNQ
                     DYQFEMLLDSIKVVREPGRNPIYDVMFTVQNLDTPVIELEEIKFRSYDTGHTTSHADLN
                     LMVLIGESKIFFSLEYLTRLFKRETIERMGEHFKKIVKVVTDNSDIRLSEIDIISETEK
                     QEILSMLNGTSGYISDGKKQRVSQVEFDF"
     PFAM_domain     complement(2916..4214)
                     /aSDomain="Condensation"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00668.22"
                     /description="Condensation domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg60_3_0005"
                     /evalue="6.10E-114"
                     /label="ctg60_3"
                     /locus_tag="ctg60_3"
                     /protein_end="580"
                     /protein_start="147"
                     /score="381.3"
                     /tool="antismash"
                     /translation="EYYPVSSAQKRMYITSRFDGIGIGYNTPMAVIAEGNIDSEKFEEA
                     VKALIRRHEVFRTSFEVVGDEVVQRIHKELDFSIEYLEVSEEETDNIVKKFIKPFDLGI
                     APLLRVGLIKQNKNKYVIIWDMHHIITDGVSLGLLLKEFTAFYEGRVVPNLRLQYKDFA
                     YWQNTLLSSGAIDKQKKYWEDRFKDGVPILNMPTDFQRPGVYSFEGEVVNFELEERLTS
                     KLHELAAETTNTMQILLLAIFNILLYKYTGQEDIVVGTATAGRQHADLENLIGMFVNML
                     ALRNYPKGDKTYREFLQEVKEFSLEAYQNQDYQFEMLLDSIKVVREPGRNPIYDVMFTV
                     QNLDTPVIELEEIKFRSYDTGHTTSHADLNLMVLIGESKIFFSLEYLTRLFKRETIERM
                     GEHFKKIVKVVTDNSDIRLSEIDIISETEKQEIL"
     CDS_motif       complement(3198..3308)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_3_0005"
                     /evalue="7.10E-13"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg60_3"
                     /protein_end="486"
                     /protein_start="449"
                     /score="40.9"
                     /tool="antismash"
                     /translation="FSLEAYQNQDYQFEMLLDSIKVVREPGRNPIYDVMFT"
     aSDomain        complement(3360..4214)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_3_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="9.40E-95"
                     /label="ctg60_3_Condensation_LCL.1"
                     /locus_tag="ctg60_3"
                     /protein_end="432"
                     /protein_start="147"
                     /score="308.9"
                     /tool="antismash"
                     /translation="EYYPVSSAQKRMYITSRFDGIGIGYNTPMAVIAEGNIDSEKFEEA
                     VKALIRRHEVFRTSFEVVGDEVVQRIHKELDFSIEYLEVSEEETDNIVKKFIKPFDLGI
                     APLLRVGLIKQNKNKYVIIWDMHHIITDGVSLGLLLKEFTAFYEGRVVPNLRLQYKDFA
                     YWQNTLLSSGAIDKQKKYWEDRFKDGVPILNMPTDFQRPGVYSFEGEVVNFELEERLTS
                     KLHELAAETTNTMQILLLAIFNILLYKYTGQEDIVVGTATAGRQHADLENLIGMFVNML
                     ALRN"
     CDS_motif       complement(3363..3452)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_3_0004"
                     /evalue="5.00E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg60_3"
                     /protein_end="431"
                     /protein_start="401"
                     /score="51.0"
                     /tool="antismash"
                     /translation="DIVVGTATAGRQHADLENLIGMFVNMLALR"
     CDS_motif       complement(3708..3743)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_3_0003"
                     /evalue="3.40E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="ctg60_3"
                     /protein_end="316"
                     /protein_start="304"
                     /score="16.4"
                     /tool="antismash"
                     /translation="QYKDFAYWQNTL"
     CDS_motif       complement(3774..3839)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_3_0002"
                     /evalue="3.40E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg60_3"
                     /protein_end="294"
                     /protein_start="272"
                     /score="32.4"
                     /tool="antismash"
                     /translation="MHHIITDGVSLGLLLKEFTAFY"
     CDS_motif       complement(4035..4142)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg60_3_0001"
                     /evalue="2.60E-12"
                     /label="C2_DCL_024-062"
                     /locus_tag="ctg60_3"
                     /protein_end="207"
                     /protein_start="171"
                     /score="39.0"
                     /tool="antismash"
                     /translation="YNTPMAVIAEGNIDSEKFEEAVKALIRRHEVFRTSF"
     aSDomain        complement(4257..4463)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_3_PCP.1"
                     /evalue="1.80E-26"
                     /label="ctg60_3_PCP.1"
                     /locus_tag="ctg60_3"
                     /protein_end="133"
                     /protein_start="64"
                     /score="84.0"
                     /tool="antismash"
                     /translation="EEKLAEIWLQVLNLERVGIEDDFFGLGGHSLKATFLVNRIHKELN
                     AELPLGRLFETPTIAGLAEYIRDA"
     PFAM_domain     complement(4266..4460)
                     /aSDomain="PP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00550.27"
                     /description="Phosphopantetheine attachment site"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg60_3_0004"
                     /evalue="3.50E-13"
                     /label="ctg60_3"
                     /locus_tag="ctg60_3"
                     /protein_end="130"
                     /protein_start="65"
                     /score="49.8"
                     /tool="antismash"
                     /translation="EKLAEIWLQVLNLERVGIEDDFFGLGGHSLKATFLVNRIHKELNA
                     ELPLGRLFETPTIAGLAEYI"
ORIGIN
        1 ctcaaggttc cctgctctct gtccagagca gttattgcct cgctgtcctt cagaacaatt
       61 accgtcccgc tgtcctccag catgtagcgt atcctttctt cgggatattc catatctata
      121 ggcagatatg cccctcccgc tttaagaacg cccagcactg ctacaacaaa ttctacagac
      181 tggtcggcca tgattgccac tatggaatcc cgctttacac ctttttccct taataccctt
      241 gcgagccggt ttgctttttc attcagctcc ctgtaagtca gatacctgcc tccggcttca
      301 atggcaatat tgtccggagt tctttccatc tgctcttcaa acaactgata tatacagcat
      361 tcctcgggat attcatggct ggaactgtta aactgatgta ttatgtaatt tctctcttct
      421 ttggatatga cagctgcatc atgaattgtt atatttacat cagtaattat gttatttaat
      481 acattctcaa gtgccgaaac taattgattt aacattcttt cgttgaaaat accgtcagtg
      541 cacgacagtt caagctcaac cgtcctgcca ttcctgtcaa acgcaaaaac cagaccatag
      601 tcggtgtttt caatatctat ctgcctgtgt atattattaa gcatgcacat cacatttata
      661 tttctaaatg gattcatttc ctgaaaatca tcgaaaatat ttaatatgtt tttaaaggga
      721 taatcctgat tttcatatgc ttttaatgct gatttaccag tatccagaat gcattccctg
      781 agtgtctttt cctctcttat ttcatcacgt atcaagacca catcattaac tgtgtattca
      841 ctgcagtaat cgctataaac cggagaacag actataatgt cgttacttcc tgtatacttg
      901 tagataagac attttaaagc cataagcaat atcaaataca acgataggtc ggattgctta
      961 cttaacatta tcaagctctc agataattca tcaggataac taaattttac tttaatgggc
     1021 cttttattcc catagtctgc tgccctagtt ttcataaaca agtttgaaga cgggtaatac
     1081 cctgagagcc tgtctaacca gtattttttt tgctgcaaga attcttcgct atttaacaat
     1141 aggttttctt gaattctgtt cataattagc cctgcctttt tcatctaagt cccgtatttt
     1201 ttgattactt ctactttgcg gctttgaaga cagcctccat tcttttttcg agttctaggc
     1261 tgatattctt ttgatttgga ctttttaatt tttcggcgat tccttcctgg aagcatgaca
     1321 taaattcttt tatctgatta atattgatac cgttttgcat gagagggaaa atacttgcag
     1381 aatcaaagtt atactggggc atccaaattg aattttttac tgagagaaaa acttcattta
     1441 ctaatttact gccggttttt gaatccattg ttttatgtga ccatttaaac tgtgaacctt
     1501 tgataccata tttttctttt tccttccata tgggagttat gggttcgcaa taccataact
     1561 gtgcgcgata gaaatccggc ctggtgtctt caataaatct tactgtttcc tgtactgttt
     1621 tatatgtttc accaggaaaa cctataataa atgaagcatt tattataata ccgtattctc
     1681 ttaatagttt catgccctct ctatattttt ctatagtaga agccttgctc atattattca
     1741 gtatttcctg gcttcccgac tcgattccaa ggaatactcc ttcacagcca ctttccttca
     1801 ttaagctgat tatctcctca tcggcaaact gacatctgaa atacgaatgc cacttaaagg
     1861 aaaacctgtt ttttatcatc attttaagaa tgtctttaaa tctatccctc ggaacattga
     1921 atgtatcatc aatgatataa atgcttttca cagtccctat actatctaag gcacgccatt
     1981 ctttttctat tgtctcaaca tccacagtct ggtattttcc cgcatgctga ggaaacccgc
     2041 aaaaagagca ggagaatgga cacgatattg ccgttctgat agttgcaaac ctgcctaccc
     2101 tatccccaaa caggctccaa tcaaccatgt tttctgctag aatattgttt tcaatctcta
     2161 tattattgcg aatataccca cttttttgct tgaagtatat attgcttatt tgattgaatt
     2221 gaagcccatt ttttaccgca ttgataatct ggactaaagc aaattccccc tgtgaactat
     2281 ttatgtagaa atctgcatca agagaacata aaatatactc catcgtcacc tcattctgcg
     2341 ttctggcatt tgttgacaca aacggcccgc ccacaataat cttggcagta gtattgtatt
     2401 gcctcacaaa tgagattatc tctgatatcg gatacgaaga aacatagagt gttgttgtta
     2461 ttgcaattgt taatacatta ttctccctga gctttttcgc taattcttct ttttcatcct
     2521 gaaaggaatt cacatagtca aatgtgaagc cccttctttt aatataggtg cccaaataag
     2581 cgattgtggc gctaaaaagc tctccaagat ttataatgtc cttattattg cctgctcttt
     2641 tataaaaagt attaaatgtt tccgctgctg ttatagcctc gctgttatac ctcacgaagt
     2701 ttaagttcaa atcctgatag ggctccgatt cttttcccat tgatcctacc attccctcat
     2761 agtcacaaaa cttcatctgg ttgtgaccta taatcaaaca atcaatactc tgtgccattt
     2821 taatctccac ctttacatta aaaatcgaat tctacttggc taactctttg ctttttacca
     2881 tcagaaatgt atccactagt accatttaac atgcttaaaa tctcttgctt ctccgtttcg
     2941 ctgattatat ctatttccga caatcttata tcagagttat ccgtaaccac ttttacaatt
     3001 tttttgaagt gttctcccat tctctcaatg gtttccctct tgaacagcct tgtcaaatac
     3061 tcgaggctga agaatatttt actttctcct ataagcacca taagatttaa atcagcatga
     3121 gaggtagtat gtccggtatc atatgatctg aactttattt cttcaagctc aattacaggc
     3181 gtgtccagat tctgaaccgt aaacatcacg tcatagattg gatttcttcc cggctccctt
     3241 acaactttta tactgtctaa cagcatctca aactggtagt cctggttttg gtatgcttct
     3301 aatgaaaatt ccttgacttc ctgcagaaac tctctatatg ttttatctcc cttgggataa
     3361 tttcttaaag caagcatatt tacaaacatt ccaataaggt tttcaaggtc ggcatgctgc
     3421 cttcccgcgg tggcagttcc tactacaata tcctcctgac ctgtatattt gtacagtaag
     3481 atattgaata ttgccaaaag taaaatctgc attgtatttg ttgtttctgc ggctaattca
     3541 tgcaattttg aagttaatcg ttcttcgagc tcaaagttaa ctacttcacc ttcaaagctg
     3601 taaacaccgg gtctttgaaa atccgtaggc atgttaagga ttggtacccc atctttaaat
     3661 ctatcctccc aatacttttt ctgcttatct attgccccag aactcagaag tgtattttgc
     3721 caatatgcaa aatctttata ttgcagcctt aaattcggca ccaccctccc ctcatagaat
     3781 gctgtaaatt ctttaagcaa taaacccaga gacacaccat ccgttataat gtggtgcata
     3841 tcccatatta taacatactt gtttttattt tgctttatta agcccaccct taacagcggc
     3901 gctatgccta agtcaaaagg ctttataaat ttttttacaa tattatcagt ttcttcctca
     3961 gatacttcta gatactcgat actgaaatct aattctttat gtatcctctg tacaacttca
     4021 tcaccaacaa cttcgaaaga tgtacgaaat acctcatgcc tccttataag tgctttaaca
     4081 gcctcttcaa acttttcaga gtcaatattt ccttctgcaa ttactgccat gggtgtgttg
     4141 tagcctatac ctattccatc aaaccgactt gttatataca ttctcttctg agctgatgat
     4201 acaggataat actccttttc ttcaacaggc tctatcgtgg cgtatatttt tttctccgca
     4261 tctcttatgt actctgcaag gccggcaatc gttggagtct cgaatagtct tcccagcggt
     4321 agctctgcat tcaactcctt gtgtatcctg tttacaagga atgtagcctt taaggaatgg
     4381 cctcccagtc cgaagaagtc atcttctatt cctacccttt ccagattcag cacctggagc
     4441 catatttctg caagcttttc ttcaattcta tcccttggac ctatgtactc ttctttcatt
     4501 ccccttccct tttttgggtc aggaagagct ttggcgtcta ctttcccgtt agttgtcatt
     4561 ggtatgcgct ctacctttac gatatatgaa ggaaccatat agaccggcag ctccttttca
     4621 agccttcttt ttatttcatt ctcctccggt tccccg
//
