LOCUS       c00016_NZ_JHYD..       21461 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JHYD01000025.1 Ruminiclostridium cellobioparum DSM 1351 = ATCC
            15832 T344DRAFT_scaffold00016.16_C, whole genome shotgun sequence.
ACCESSION   NZ_JHYD01000025
VERSION     NZ_JHYD01000025
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:33:25
            Original ID  :: NZ_JHYD01000025.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 58416
            Orig. end    :: 79877
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21461
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[68416:69877](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11461)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..21461
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..21461
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     YcaO or TIGR03882)))"
                     /tool="antismash"
     CDS             complement(1008..2408)
                     /locus_tag="ctg16_49"
                     /transl_table=11
                     /translation="LDEIKLRRYSVKKLLVLLSALYCLVFVINSMALGYEYKFDGDYGK
                     RIEVNIKNNLIPEGRTLKLQNLESLINRSGLNYSYQCEAEAYIKAGSKGYPVKRVLSGR
                     NLSGFLGLRMLKGSFFNGSQHEYGKKVAVISETLAEKLYMTNNVLGNEVEISGIKYKVT
                     GVYQNKNRPFSILSSDGVERIYVPFESLTGYKDLTIETVFLKGQSLQEEIFRTDKVNSL
                     LKQAGVNTDYYRLKDFYDSSVFISQPLSAFIFFVGILIMIILAKGTVRYIKGGISNFEQ
                     RMKAGYLFEVIKSSKLGILIFLAGAAFLLCGIAAVFFMVRFKGSIPYQYIPPDNIFDFQ
                     FYGGLIREALYNANEFNGYRPTQYELQVHYGLVAVYCLTVLLVISFIAVGSAIKLNRFL
                     MYSSLNSLTVLGGAIVLGTVSGFIICLIFGIQSASPVRSFTALSIYFCARLIRIPEGIS
                     HANFGLQK"
     PFAM_domain     complement(1818..2096)
                     /aSDomain="MacB_PCD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12704.9"
                     /description="MacB-like periplasmic core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_49_0001"
                     /evalue="1.80E-11"
                     /label="ctg16_49"
                     /locus_tag="ctg16_49"
                     /protein_end="197"
                     /protein_start="104"
                     /score="44.8"
                     /tool="antismash"
                     /translation="NLSGFLGLRMLKGSFFNGSQHEYGKKVAVISETLAEKLYMTNNVL
                     GNEVEISGIKYKVTGVYQNKNRPFSILSSDGVERIYVPFESLTGYKDL"
     CDS             complement(2414..3715)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 131.4; E-value:
                     6.1e-40)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_50"
                     /transl_table=11
                     /translation="MDNIQTESQLLKRKKIIRRTAVAFICVIILLTFFSSTINNFLLPT
                     VECDTASSGTLTNEITAEGEIFPVGTEAVYAYGTWKVRDIKVEEEQEVAPGEELAVIDS
                     RDLQLDIKKAELNVQKLENELKRYKNGFQEADMEQYRNDCEAALKAVQKAQKNLDDQKE
                     LYAVDAVSLQEVNDAQDKLDAANREYNEKQRTLSQKETEIKKAGESYGINIAEKESELE
                     VGKLELQKMKNNIPMDGIIKAPVGGTIKSISIEKGSVTGSGQVLFEIVKKESGLAVRWT
                     LETKPAGEVEINDTVEISGEADENFNFNGKVKDKKYLTEQGKYQFTSYLENSKENLKIG
                     QKVDVKVRRESRQYKTLVPNSSIVDEGGRKYVFLLKERKGVLGTETNVQKVEITVQEEA
                     DLYSAVSLNGFAGDEKIVVFSSKALSDGLQVKLR"
     PFAM_domain     complement(2777..2995)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_50_0002"
                     /evalue="1.90E-08"
                     /label="ctg16_50"
                     /locus_tag="ctg16_50"
                     /protein_end="313"
                     /protein_start="240"
                     /score="35.0"
                     /tool="antismash"
                     /translation="IKAPVGGTIKSISIEKGSVTGSGQVLFEIVKKESGLAVRWTLETK
                     PAGEVEINDTVEISGEADENFNFNGKVK"
     CDS             complement(3736..4629)
                     /gene_functions="transport (smcogs) SMCOG1069:putative ABC
                     transporter permease protein (Score: 202.8; E-value:
                     1.1e-61)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_51"
                     /transl_table=11
                     /translation="MKTMENFLAGSGIKLKSLVKYIIMLCISAALLFPVVYMLANSFMS
                     SSEVMENYSAVSGAAVEEGRTPGITFSLIPEKVSFMQYYNVLLRKPRFLFMFWNSVMVT
                     VPIMLGQIVVATMAAYAFAKLKFPFSDKIFYIYIIVMMMPYQVTLVPNYIILDRTNLIG
                     SYWSIILPGVFSTFGVFLLRQFMINIPDDYCEAAKIDGAGYWKSLTSILLPQCKGAIAS
                     LAILVFIDNWNMVEQPLVFLKDETMHPLSIFLSRINSEDIGIAFACGILYMFPTLLIFL
                     YGENYFIEGIELSGIK"
     PFAM_domain     complement(3787..4296)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_51_0003"
                     /evalue="4.60E-13"
                     /label="ctg16_51"
                     /locus_tag="ctg16_51"
                     /protein_end="281"
                     /protein_start="111"
                     /score="49.4"
                     /tool="antismash"
                     /translation="IVVATMAAYAFAKLKFPFSDKIFYIYIIVMMMPYQVTLVPNYIIL
                     DRTNLIGSYWSIILPGVFSTFGVFLLRQFMINIPDDYCEAAKIDGAGYWKSLTSILLPQ
                     CKGAIASLAILVFIDNWNMVEQPLVFLKDETMHPLSIFLSRINSEDIGIAFACGILYMF
                     PTLLIFL"
     CDS             complement(4631..5509)
                     /gene_functions="transport (smcogs) SMCOG1067:putative ABC
                     transporter permease protein (Score: 198.4; E-value:
                     2.5e-60)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_52"
                     /transl_table=11
                     /translation="MTVLQTKLKTRQSIAGFIFALPSLAGFALFFAIPFAISIYYCFTQ
                     GIGGIEFVGFQNFIDLFHSNSFLLASKNTIIFNAISVPAIIILSFLLSLLLNSRIKGLP
                     VFRSFFILPLVIPVASVILVWNILFNEYGVINSILIKFGFAGNIDWIKSDQSMWVLVLL
                     YLWKNCGYNVILFLAGLSNIPKEYYESARMDGAGPLACIKNITIPFLIPTGFFVLMMSI
                     VNSFKVFREAYLLAGSYPSLKIYMLQHFMNNNFMNLSYQRLTTAALIMAVVIALLVFIV
                     FKIEARFGRSI"
     PFAM_domain     complement(4664..5236)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_52_0004"
                     /evalue="7.10E-13"
                     /label="ctg16_52"
                     /locus_tag="ctg16_52"
                     /protein_end="282"
                     /protein_start="91"
                     /score="48.8"
                     /tool="antismash"
                     /translation="LSLLLNSRIKGLPVFRSFFILPLVIPVASVILVWNILFNEYGVIN
                     SILIKFGFAGNIDWIKSDQSMWVLVLLYLWKNCGYNVILFLAGLSNIPKEYYESARMDG
                     AGPLACIKNITIPFLIPTGFFVLMMSIVNSFKVFREAYLLAGSYPSLKIYMLQHFMNNN
                     FMNLSYQRLTTAALIMAVVIALLVFIVF"
     CDS             complement(5703..5888)
                     /locus_tag="ctg16_53"
                     /transl_table=11
                     /translation="LTEQLAHRMDKIRANVGSGKLYENEVYKIIEEELPEFLNGNKSAG
                     GTAKTIDDRITIYLNE"
     CDS             complement(5914..7044)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143:sugar-binding lipoprotein (Score: 123.1; E-value:
                     2.9e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_54"
                     /transl_table=11
                     /translation="LHFQHNMNVRVKKINIILLIMVFSINLISCSEQNNSTNSSKSQLT
                     IYLMDSDKTLLNAVDKYNKVNSNAKIEAKVFSDIQEFKNKNTTGLLSGNGPDIIVNRLD
                     MLSNTNKVVSNGVFYDINKLITEDRDFKLSDYNEKILDYGVYAGKRYLIPINYVNSGFL
                     TTQEILNKNNIKLDENNLMWNNVAEIVKKFIADNKSKGKYFINSLSFTQFLCSLGNPFI
                     DYDKKKTSYASKEFIEVLNFYKDIYPAICPGRISSKYSYTELLKNGTVVMVNTAGIYSP
                     YSLYEAYNQITRLFNKQEVRIFAFPTWNKGDVNTVWPYYLLSINAKCKSKPDAFAFIKL
                     LLSDEYQQQAGKDDPNWYTPVSESAYNLDKKFCLSK"
     PFAM_domain     complement(6001..6891)
                     /aSDomain="SBP_bac_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01547.27"
                     /description="Bacterial extracellular solute-binding
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_54_0005"
                     /evalue="6.30E-16"
                     /label="ctg16_54"
                     /locus_tag="ctg16_54"
                     /protein_end="348"
                     /protein_start="51"
                     /score="59.3"
                     /tool="antismash"
                     /translation="DKTLLNAVDKYNKVNSNAKIEAKVFSDIQEFKNKNTTGLLSGNGP
                     DIIVNRLDMLSNTNKVVSNGVFYDINKLITEDRDFKLSDYNEKILDYGVYAGKRYLIPI
                     NYVNSGFLTTQEILNKNNIKLDENNLMWNNVAEIVKKFIADNKSKGKYFINSLSFTQFL
                     CSLGNPFIDYDKKKTSYASKEFIEVLNFYKDIYPAICPGRISSKYSYTELLKNGTVVMV
                     NTAGIYSPYSLYEAYNQITRLFNKQEVRIFAFPTWNKGDVNTVWPYYLLSINAKCKSKP
                     DAFAFIKLLLSDEYQQ"
     CDS             complement(7156..8493)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143:sugar-binding lipoprotein (Score: 92; E-value:
                     7.7e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_55"
                     /transl_table=11
                     /translation="MRKHYLLLLIIPMITFSSCETNEVIDNKRQNEKIELEVSVRVNDQ
                     TTHNAIDKFNAKNKNIKLMIDDIPLYINKEYSEKLTADLMAGGGPDLFCDNTDIFPSIY
                     KTIQNKTFYDLNKLIKKDKEFRLDDYYEEVLNCGVIDGKRYILPTNFDVHIFYGFDNIL
                     KSNNINIDNKNFSWEMLSKISLQFINNNKGKYFFVPMDFQTIFESYGKSFVDYKSKKAN
                     FNSDEFINLLKNYRDIIPTICPPEYAMKYRGLYWGMVKDNALILLQTYSTNPEFFWTEY
                     NFGKNVLNSDIKIYPYPSSQHNGNYSAYVKKFTAISNKCKHPEEAFEFIKYVLSKEIQK
                     DTVISSAPVNKEAYREIIAYYSSEEKRGKDIKNPADDKTYKSKAIPEDLARILEDIPEK
                     VNTCNFIDQSVLTIINDEMINFLNGSKSAEQTAKAINEKVLLFLNE"
     PFAM_domain     complement(7432..8346)
                     /aSDomain="SBP_bac_8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13416.8"
                     /description="Bacterial extracellular solute-binding
                     protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_55_0006"
                     /evalue="9.80E-16"
                     /label="ctg16_55"
                     /locus_tag="ctg16_55"
                     /protein_end="354"
                     /protein_start="49"
                     /score="58.5"
                     /tool="antismash"
                     /translation="AIDKFNAKNKNIKLMIDDIPLYINKEYSEKLTADLMAGGGPDLFC
                     DNTDIFPSIYKTIQNKTFYDLNKLIKKDKEFRLDDYYEEVLNCGVIDGKRYILPTNFDV
                     HIFYGFDNILKSNNINIDNKNFSWEMLSKISLQFINNNKGKYFFVPMDFQTIFESYGKS
                     FVDYKSKKANFNSDEFINLLKNYRDIIPTICPPEYAMKYRGLYWGMVKDNALILLQTYS
                     TNPEFFWTEYNFGKNVLNSDIKIYPYPSSQHNGNYSAYVKKFTAISNKCKHPEEAFEFI
                     KYVLSKEIQKDTVISSAPVNKEAY"
     CDS             complement(8630..8908)
                     /locus_tag="ctg16_56"
                     /transl_table=11
                     /translation="MKSVDYLILNRIFEERLGLDISLVDFNTDMLSGQFGIEPRDLVYL
                     FFDIEREFNITIPEKDIVSGEFKTLNRMINLIDRQLKKNREETIQNV"
     PFAM_domain     complement(8678..8878)
                     /aSDomain="PP-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00550.27"
                     /description="Phosphopantetheine attachment site"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_56_0007"
                     /evalue="5.20E-05"
                     /label="ctg16_56"
                     /locus_tag="ctg16_56"
                     /protein_end="77"
                     /protein_start="10"
                     /score="23.6"
                     /tool="antismash"
                     /translation="RIFEERLGLDISLVDFNTDMLSGQFGIEPRDLVYLFFDIEREFNI
                     TIPEKDIVSGEFKTLNRMINLI"
     CDS             complement(8929..10032)
                     /locus_tag="ctg16_57"
                     /transl_table=11
                     /translation="MREKLLIFPYSFEIIPLLNHYSLLDKFEIIGGITFGHKDNYCSFN
                     KGKIDIQKMDKFKLLLECCDTVLICDNLLSIDYNEFIFSKILEAIKHKKNIISVMDIDD
                     KRNDIISELCKEYGVHYQSCINREQKSYLIFKENLYRIGTPVVFVMGMGERTCKFEIQL
                     SIREEIKRLGYKVAQVGSRKYCELMGFHSFPNFMFDKSISEAEKIISFNRFIKEIEIEE
                     SPDLIIIGIPGGTMKLNNEYTHNFGIIAYEVSQALTPDFVLVSSFYENYKPEYFKKIST
                     ALKYKFGYEIDCFNLSNVQCHWPNAGEFTELEYLTIDPSFIDKKLKNYKDLKIPLFNIF
                     NSNDSKEIATSIIDKLSYYGEYSLFTN"
     aSDomain        complement(8962..10026)
                     /aSDomain="TIGR04066"
                     /aSTool="tigrfam"
                     /description="nat_prod_clost: peptide maturation system
                     protein, TIGR04066 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg16_57_0001"
                     /evalue="3.90E-115"
                     /identifier="TIGR04066"
                     /label="ctg16_57"
                     /locus_tag="ctg16_57"
                     /protein_end="357"
                     /protein_start="2"
                     /score="382.6"
                     /tool="antismash"
                     /translation="EKLLIFPYSFEIIPLLNHYSLLDKFEIIGGITFGHKDNYCSFNKG
                     KIDIQKMDKFKLLLECCDTVLICDNLLSIDYNEFIFSKILEAIKHKKNIISVMDIDDKR
                     NDIISELCKEYGVHYQSCINREQKSYLIFKENLYRIGTPVVFVMGMGERTCKFEIQLSI
                     REEIKRLGYKVAQVGSRKYCELMGFHSFPNFMFDKSISEAEKIISFNRFIKEIEIEESP
                     DLIIIGIPGGTMKLNNEYTHNFGIIAYEVSQALTPDFVLVSSFYENYKPEYFKKISTAL
                     KYKFGYEIDCFNLSNVQCHWPNAGEFTELEYLTIDPSFIDKKLKNYKDLKIPLFNIFNS
                     NDSKEIATSIIDKLS"
     CDS             complement(10001..11461)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_58"
                     /sec_met_domain="PF04055 (E-value: 9e-15, bitscore: 48.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7e-12, bitscore: 39.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.7e-11, bitscore:
                     35.5, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.2e-14, bitscore: 47.7, seeds: 13, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSHKPFIHTFRVGGKDYIYDVNRNVILKGQNELIKLLVGDQTSL
                     DNVENNYIVDLLAKMKNDGFFSSNKIKEILHPADELIEYYLNSKIQKITLQLTQNCNLN
                     CSYCAYSGGYYNRTHTKSRMDFEIAKRSIDFLLEHSGDNKEINIGFYGGEPLLEKELMR
                     KCIKYAKQNSYGKKLSFTITTNGTLLNESIIQLFEENDVYLVISLDGPKEVQDRNRKFA
                     CTSDSTFEIVMSNVNLIKQKYPDYYKNICFNAVLDQENEFCCVDNFFKDFDLVKEAVVL
                     ASEINPNLKKDLVKNDQTFINNYRYEIFKLFLSKLGRLDQSYVSKLVRTYFISLEKTYA
                     QLKVTEKLPEKAHHGGPCIPGSQRLFVDTQGTLFPCERVSETSEIMKIGNVFDGFNYDN
                     IREILNIGKLSEDKCKNCWAFRFCGSCAAMADSVNGLSKYEKISKCNGTMKFAEDRLKD
                     ICMLKQMKYEFNRFIGGQNERKTVDISL"
     aSDomain        complement(10058..11443)
                     /aSDomain="TIGR04068"
                     /aSTool="tigrfam"
                     /description="rSAM_ocin_clost: Cys-rich peptide radical SAM
                     maturase CcpM"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg16_58_0002"
                     /evalue="4.70E-177"
                     /identifier="TIGR04068"
                     /label="ctg16_58"
                     /locus_tag="ctg16_58"
                     /protein_end="468"
                     /protein_start="6"
                     /score="587.5"
                     /tool="antismash"
                     /translation="FIHTFRVGGKDYIYDVNRNVILKGQNELIKLLVGDQTSLDNVENN
                     YIVDLLAKMKNDGFFSSNKIKEILHPADELIEYYLNSKIQKITLQLTQNCNLNCSYCAY
                     SGGYYNRTHTKSRMDFEIAKRSIDFLLEHSGDNKEINIGFYGGEPLLEKELMRKCIKYA
                     KQNSYGKKLSFTITTNGTLLNESIIQLFEENDVYLVISLDGPKEVQDRNRKFACTSDST
                     FEIVMSNVNLIKQKYPDYYKNICFNAVLDQENEFCCVDNFFKDFDLVKEAVVLASEINP
                     NLKKDLVKNDQTFINNYRYEIFKLFLSKLGRLDQSYVSKLVRTYFISLEKTYAQLKVTE
                     KLPEKAHHGGPCIPGSQRLFVDTQGTLFPCERVSETSEIMKIGNVFDGFNYDNIREILN
                     IGKLSEDKCKNCWAFRFCGSCAAMADSVNGLSKYEKISKCNGTMKFAEDRLKDICMLKQ
                     MKYE"
     aSDomain        complement(10136..10390)
                     /aSDomain="TIGR04085"
                     /aSTool="tigrfam"
                     /description="rSAM_more_4Fe4S: radical SAM additional
                     4Fe4S-binding SPASM domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg16_58_0003"
                     /evalue="2.40E-09"
                     /identifier="TIGR04085"
                     /label="ctg16_58"
                     /locus_tag="ctg16_58"
                     /protein_end="442"
                     /protein_start="357"
                     /score="35.5"
                     /tool="antismash"
                     /translation="CIPGSQRLFVDTQGTLFPCERVSETSEIMKIGNVFDGFNYDNIRE
                     ILNIGKLSEDKCKNCWAFRFCGSCAAMADSVNGLSKYEKI"
     PFAM_domain     complement(10802..11170)
                     /aSDomain="Fer4_12"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13353.8"
                     /description="4Fe-4S single cluster domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_58_0008"
                     /evalue="2.10E-09"
                     /label="ctg16_58"
                     /locus_tag="ctg16_58"
                     /protein_end="220"
                     /protein_start="97"
                     /score="38.1"
                     /tool="antismash"
                     /translation="TQNCNLNCSYCAYSGGYYNRTHTKSRMDFEIAKRSIDFLLEHSGD
                     NKEINIGFYGGEPLLEKELMRKCIKYAKQNSYGKKLSFTITTNGTLLNESIIQLFEEND
                     VYLVISLDGPKEVQDRNRK"
     CDS             complement(12807..13043)
                     /locus_tag="ctg16_59"
                     /transl_table=11
                     /translation="MGKLILILFVLLLLMCFCIYNWWERREKSKRLFEEEKKKINPLNT
                     HTAWGIYAFAALLAILGIAAYEIYQLMLKIYTI"
     CDS             complement(13243..16110)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 52.7; E-value:
                     8.3e-16)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_60"
                     /transl_table=11
                     /translation="MPIRTHIEISGAKQNNLKNISVDIPRDKLTVITGVSGSGKSSLAF
                     DVIYGEGQRRFLDSISNFAKSRISQLKKAKVDYVRGLSPVIAIEQKKSNNNPRSTVGTV
                     TDINDYMRLLFSAAGVGKCPECGHQLKQLSAAQIAEHISTLPAGTVVELRAPVYKIYGE
                     DYDYTFHQLREKGFKNLLVDGEPFSLADKRELDENVEYKIELVIDRFTLKNDTYIQLTK
                     SIEAAMLALDEDIMLKVEVEGNAGREFYTGFGCPEHHHILCEMQPFHFSFNTPASACHT
                     CLGVGMSYVVEPRFLIVSPEKSLNRGALRNTVYSPGNKDSYRSVVMYSLSQKYNFSLDI
                     PFRDLPKEIHELLFYGSKGEPVEMLQPPYSQKRNWITGRARPFAGFVHELESWYRHYIR
                     KTSTSEAFEPTFIKECMIEKICPECNGARLKRQRLHITVGGRNIDQLSRMQLPELLDFL
                     KSLTFEEDIREIAESVIREISSRLELLIDIGLHYISLARRSDSVSGGEMQRIKMSTQIS
                     SELMGMLYVMDEPSIGLHPRDSQRVIDTMKKLRDIGNTVIVVEHDMDTIKSADHIIEIG
                     PGPGVHGGNIVASGTVEDIMREQASVTGKYLSGSTSIPVPAHRRNLGDNFLSIQGAREN
                     NLKDVDIDIPLGVFICITGVSGSGKSSLINEILYKQLKINKTGARIVAGEHDFLFGTEL
                     LNNVINIDQSPIGKNSKSNPATYIGIYDKIREIFANQPEAIHRGYSEIDFSLTHANGTR
                     CEHCAGDGIIVTNLQFMADIETICPVCKGRRFSDEGLEIKYKQKSIADVLDMTAEEALE
                     FFKDEKYLRHKLNIINELGLGYMTLGQSSTTLSGGEAQRVKLAYELSKIKRGAHNLYIL
                     DEPTTGLHLSDIRKLIDCLIKLVDNGHTVLVIEHHLDVIKSADYIIDMGPEGGSGGGMV
                     VAEGTPEQVANVKTSHTGRFLKEVL"
     aSDomain        complement(13291..16092)
                     /aSDomain="TIGR00630"
                     /aSTool="tigrfam"
                     /description="uvra: excinuclease ABC subunit A"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg16_60_0004"
                     /evalue="0.00E+00"
                     /identifier="TIGR00630"
                     /label="ctg16_60"
                     /locus_tag="ctg16_60"
                     /protein_end="940"
                     /protein_start="6"
                     /score="1129.1"
                     /tool="antismash"
                     /translation="IEISGAKQNNLKNISVDIPRDKLTVITGVSGSGKSSLAFDVIYGE
                     GQRRFLDSISNFAKSRISQLKKAKVDYVRGLSPVIAIEQKKSNNNPRSTVGTVTDINDY
                     MRLLFSAAGVGKCPECGHQLKQLSAAQIAEHISTLPAGTVVELRAPVYKIYGEDYDYTF
                     HQLREKGFKNLLVDGEPFSLADKRELDENVEYKIELVIDRFTLKNDTYIQLTKSIEAAM
                     LALDEDIMLKVEVEGNAGREFYTGFGCPEHHHILCEMQPFHFSFNTPASACHTCLGVGM
                     SYVVEPRFLIVSPEKSLNRGALRNTVYSPGNKDSYRSVVMYSLSQKYNFSLDIPFRDLP
                     KEIHELLFYGSKGEPVEMLQPPYSQKRNWITGRARPFAGFVHELESWYRHYIRKTSTSE
                     AFEPTFIKECMIEKICPECNGARLKRQRLHITVGGRNIDQLSRMQLPELLDFLKSLTFE
                     EDIREIAESVIREISSRLELLIDIGLHYISLARRSDSVSGGEMQRIKMSTQISSELMGM
                     LYVMDEPSIGLHPRDSQRVIDTMKKLRDIGNTVIVVEHDMDTIKSADHIIEIGPGPGVH
                     GGNIVASGTVEDIMREQASVTGKYLSGSTSIPVPAHRRNLGDNFLSIQGARENNLKDVD
                     IDIPLGVFICITGVSGSGKSSLINEILYKQLKINKTGARIVAGEHDFLFGTELLNNVIN
                     IDQSPIGKNSKSNPATYIGIYDKIREIFANQPEAIHRGYSEIDFSLTHANGTRCEHCAG
                     DGIIVTNLQFMADIETICPVCKGRRFSDEGLEIKYKQKSIADVLDMTAEEALEFFKDEK
                     YLRHKLNIINELGLGYMTLGQSSTTLSGGEAQRVKLAYELSKIKRGAHNLYILDEPTTG
                     LHLSDIRKLIDCLIKLVDNGHTVLVIEHHLDVIKSADYIIDMGPEGGSGGGMVVAEGTP
                     EQVA"
     PFAM_domain     complement(13486..14202)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_60_0011"
                     /evalue="1.40E-08"
                     /label="ctg16_60"
                     /locus_tag="ctg16_60"
                     /protein_end="875"
                     /protein_start="636"
                     /score="35.4"
                     /tool="antismash"
                     /translation="LKDVDIDIPLGVFICITGVSGSGKSSLINEILYKQLKINKTGARI
                     VAGEHDFLFGTELLNNVINIDQSPIGKNSKSNPATYIGIYDKIREIFANQPEAIHRGYS
                     EIDFSLTHANGTRCEHCAGDGIIVTNLQFMADIETICPVCKGRRFSDEGLEIKYKQKSI
                     ADVLDMTAEEALEFFKDEKYLRHKLNIINELGLGYMTLGQSSTTLSGGEAQRVKLAYEL
                     SKIKRGAHNLYILDEPT"
     PFAM_domain     complement(14923..15228)
                     /aSDomain="UvrA_DNA-bind"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17755.3"
                     /description="UvrA DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_60_0010"
                     /evalue="5.70E-13"
                     /label="ctg16_60"
                     /locus_tag="ctg16_60"
                     /protein_end="396"
                     /protein_start="294"
                     /score="49.3"
                     /tool="antismash"
                     /translation="FLIVSPEKSLNRGALRNTVYSPGNKDSYRSVVMYSLSQKYNFSLD
                     IPFRDLPKEIHELLFYGSKGEPVEMLQPPYSQKRNWITGRARPFAGFVHELESWYRH"
     PFAM_domain     complement(15427..15711)
                     /aSDomain="UvrA_inter"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17760.3"
                     /description="UvrA interaction domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_60_0009"
                     /evalue="1.90E-17"
                     /label="ctg16_60"
                     /locus_tag="ctg16_60"
                     /protein_end="228"
                     /protein_start="133"
                     /score="63.2"
                     /tool="antismash"
                     /translation="SAAQIAEHISTLPAGTVVELRAPVYKIYGEDYDYTFHQLREKGFK
                     NLLVDGEPFSLADKRELDENVEYKIELVIDRFTLKNDTYIQLTKSIEAAM"
     CDS             complement(16164..17078)
                     /locus_tag="ctg16_61"
                     /transl_table=11
                     /translation="MDEKRQAELKERYNGAVDSFVEKIKGDPNVIAVIVSGSLAYDMIW
                     EKSDIDMTLVVRDQNLKNDSYSIIEDGITINVYITVRSSFRRYMERNIGGSFMQAYFSK
                     GKIVYTTDESLYDFFEDIKVMGSDDIALSVFYMAGELIGIYDKCQKWLTAREDPLYTQY
                     YILKAAEVIANMELCLAGIPASRESIQKAAALNPDLLKTFYQEAMSRCYSIEELKAAID
                     KIDGYLMSKLDIIQKPVIEFMGDNEIKTSTLIAKHFHVDSHYIIDVFDYLADKGVIERV
                     SQTIRITPKSKLAVEEQGFLLVP"
     CDS             17281..18171
                     /locus_tag="ctg16_62"
                     /transl_table=11
                     /translation="LDNHLLELIKETTGFIENNLLEPLNLDNISENVNVSKFHLLRIWK
                     GATFTGLMEYVRRRRIAQSLSDLIHERNSIEFISSKYSFGSERTYNRVFKEEFGITPAK
                     WRKNPCPLEILDRFNADFMNCAGEGLVFLRSITVLPAFSIAGLEYRVEVEDNAVNQTAN
                     KLGVDFFYNHRLRVFNPVEKDVYIGLTTVPPHAEGYTFYQPSVGIDQSSIVPPDMKIRN
                     IQPHKYGVFTYMGPHRPEDISSKTLSGIWEYIFTTWMPNVDFNLKQKFRFERINYAKCS
                     KQYSECDLYYPISYI"
     PFAM_domain     17371..17604
                     /aSDomain="HTH_18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12833.9"
                     /description="Helix-turn-helix domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_62_0012"
                     /evalue="1.60E-10"
                     /label="ctg16_62"
                     /locus_tag="ctg16_62"
                     /protein_end="108"
                     /protein_start="30"
                     /score="41.2"
                     /tool="antismash"
                     /translation="ENVNVSKFHLLRIWKGATFTGLMEYVRRRRIAQSLSDLIHERNSI
                     EFISSKYSFGSERTYNRVFKEEFGITPAKWRKN"
     PFAM_domain     17686..18159
                     /aSDomain="Cass2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14526.8"
                     /description="Integron-associated effector binding protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_62_0013"
                     /evalue="4.40E-12"
                     /label="ctg16_62"
                     /locus_tag="ctg16_62"
                     /protein_end="293"
                     /protein_start="135"
                     /score="46.5"
                     /tool="antismash"
                     /translation="ITVLPAFSIAGLEYRVEVEDNAVNQTANKLGVDFFYNHRLRVFNP
                     VEKDVYIGLTTVPPHAEGYTFYQPSVGIDQSSIVPPDMKIRNIQPHKYGVFTYMGPHRP
                     EDISSKTLSGIWEYIFTTWMPNVDFNLKQKFRFERINYAKCSKQYSECDLYYPI"
     CDS             complement(18196..19443)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 63.4; E-value: 3.8e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_63"
                     /sec_met_domain="Peptidase_S8 (E-value: 7e-12, bitscore:
                     38.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKTHIAIIDDGVNEKLYKIGKLKHNIQVTPELKICERVDYDPFM
                     TSHGTTCAAIINKYAPETVLSSIKILDGESHTGMKAQLIKALKWCADNGIRLVNLSLGT
                     IDYRDFNEIRESVSYAREKGVVIVAACNNRNIFTCPASLGDVIGVRCDCQDKLGEKEYI
                     YNQKAPDGIEITANGCHKLKKFNGESKTTSMCNSYAAPLITALVYEIIRNNPDILLPDI
                     REKLRKASILTDRIEREESLPCNHTSYSMVDRNMDAPVIALYNYCGKESEYLGRKLTDA
                     FRKDGYNAISIFEGKTAQDYCAGYINISSFIENKGDFITGALQRIFNVFDPDIMLVSVD
                     MANQHKQNCINDMEGNFETDININVYENLKIEIKSSNETRTFALQGDLEIDGLYSYITG
                     LFAKHEYDYETDANKD"
     PFAM_domain     complement(18775..19434)
                     /aSDomain="Peptidase_S8"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00082.24"
                     /description="Subtilase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_63_0014"
                     /evalue="3.90E-13"
                     /label="ctg16_63"
                     /locus_tag="ctg16_63"
                     /protein_end="223"
                     /protein_start="3"
                     /score="49.4"
                     /tool="antismash"
                     /translation="THIAIIDDGVNEKLYKIGKLKHNIQVTPELKICERVDYDPFMTSH
                     GTTCAAIINKYAPETVLSSIKILDGESHTGMKAQLIKALKWCADNGIRLVNLSLGTIDY
                     RDFNEIRESVSYAREKGVVIVAACNNRNIFTCPASLGDVIGVRCDCQDKLGEKEYIYNQ
                     KAPDGIEITANGCHKLKKFNGESKTTSMCNSYAAPLITALVYEIIRNNPDILLPDIR"
     CDS             complement(19658..20743)
                     /NRPS_PKS="Domain: NAD_binding_4 (95-254). E-value:
                     8.4e-10. Score: 30.0. Matches aSDomain:
                     nrpspksdomains_ctg16_64_NAD_binding_4.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     155.1; E-value: 4.7e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_64"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1e-14, bitscore:
                     47.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRSQGDSEIKGEHALDKYMEQDCREYITRIDLTPLKGKTVLITG
                     ANGLIGTYLIYMLHISNVVNGTGINIEAVSRSTPNKALSEVFDSNYRFHPLDLNLPDSL
                     DMLQKADYIIHGATYAQPGKFLRNYLDTIHLNTVVAEKLLQKARVNNADFLYMSSSEVY
                     GEPDADNIPTREEFPGLCSPVNIRSIYSEAKRIGETLCFAYKNYENVNAKIARISMTYG
                     PGVSANDERVLTQFIRQALNKKEIIMMDSGSKVRTFCYIADCVLMLLNVMLYGTQLVYN
                     VGGKESITIRKLAEEICAITGSKLSVENSEYNFAEKVKVSPQHVELCIERICSEFGLDN
                     FKPMSEGLMRTIEWNRRNYNF"
     PFAM_domain     complement(19895..20623)
                     /aSDomain="Epimerase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01370.23"
                     /description="NAD dependent epimerase/dehydratase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg16_64_0015"
                     /evalue="4.00E-37"
                     /label="ctg16_64"
                     /locus_tag="ctg16_64"
                     /protein_end="283"
                     /protein_start="40"
                     /score="128.1"
                     /tool="antismash"
                     /translation="VLITGANGLIGTYLIYMLHISNVVNGTGINIEAVSRSTPNKALSE
                     VFDSNYRFHPLDLNLPDSLDMLQKADYIIHGATYAQPGKFLRNYLDTIHLNTVVAEKLL
                     QKARVNNADFLYMSSSEVYGEPDADNIPTREEFPGLCSPVNIRSIYSEAKRIGETLCFA
                     YKNYENVNAKIARISMTYGPGVSANDERVLTQFIRQALNKKEIIMMDSGSKVRTFCYIA
                     DCVLMLLNVMLYGTQLVYNVG"
     aSDomain        complement(19982..20458)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg16_64_NAD_binding_4.1"
                     /evalue="8.40E-10"
                     /label="ctg16_64_NAD_binding_4.1"
                     /locus_tag="ctg16_64"
                     /protein_end="254"
                     /protein_start="95"
                     /score="30.0"
                     /tool="antismash"
                     /translation="LDLNLPDSLDMLQKADYIIHGATYAQPGKFLRNYLDTIHLNTVVA
                     EKLLQKARVNNADFLYMSSSEVYGEPDADNIPTREEFPGLCSPVNIRSIYSEAKRIGET
                     LCFAYKNYENVNAKIARISMTYGPGVSANDERVLTQFIRQALNKKEIIMMDSGSK"
ORIGIN
        1 gccgcaatat atgcatcctt taccacctct ataccccgtc ttctcttaac catggggttt
       61 tccatgtagg tgagctcctg atcggcggat aaacgtttgc aatcggtata aactattctg
      121 gaaccataca ttcttatata ttccttcaag gtctcctggc agtcggtaag aagaaatatc
      181 ctttttatat tgtacttttc gatcagcttt tggatatccc tgtgataagc tttgttaggc
      241 tccttgtgtt tacctttttt caaatactta accacttttt cgtcaattct gtccgattct
      301 tttttttcct ttgtgtatac tttattccag tactggttgt caaatttgtc ggcatctctt
      361 gtatcaaaaa ccagctcttc attgactctt ctgacatgca cggcaagggc gggatggccg
      421 tccttcagcc aggaattgta aaagccctgt atctccatat taatatcggg ctttattctt
      481 atatatttat tgaaaagata atgatatacc tgttcaacag acattccata agcagcgtga
      541 tttttcttta taaagggaat aagttcgtag acattgtaat aaacatctcc caccaccaca
      601 ttggccttgc tccccaatat atcccctaca ttgcggaagg tccaggtatc ctttgtatta
      661 tcgtcgacca aaagattgtc ggaatcccat atggggggat aataggtata ttggggatgg
      721 gccagatcaa atatggaata gctgtttatt ggctcgaaat acagctcaaa gccgtttgtc
      781 tgtacaaagc cgttgttaag acagtgggta ggccaatata ccacagggat cctgtctgta
      841 atttcagcta tgagaagatg acccaataca tggtctatat caccccacag tacataactc
      901 caagccttta taagcaggaa tctatctttt gccatgtttc ttttcacctc aatttatggt
      961 attcatgata ttttatgtaa tccataaatg atttgtgaaa catttttcta tttttgtaaa
     1021 ccaaagtttg catgactgat accttcaggt attctgatca gcctggcaca gaaataaatg
     1081 cttaaagcag tgaaagacct gaccggagaa gcggattgaa tgccaaatat cagacagatg
     1141 ataaagcctg ataccgtgcc cagcactatt gcaccgccca gcacggttaa gctgtttaag
     1201 gatgaataca ttaaaaaccg gtttaatttg atggcagatc ccactgcaat aaaactgatg
     1261 acaagcagga ctgtcaggca gtaaacggca accagtccat agtgaacctg caattcatat
     1321 tgtgtaggtc tgtacccatt aaactcattg gcgttgtaaa gagcttccct tatcaaaccg
     1381 ccataaaact gaaaatcaaa aatattatcc ggaggtatgt actgataggg tatgctcccc
     1441 ttaaatctga ccatgaaaaa tacggcagca ataccgcaaa gcagaaatgc cgctcccgct
     1501 aaaaagatca atattcccag ttttgaactt ttaataacct caaataaata ccctgctttc
     1561 atgcgctgct caaaatttga aataccgcct ttaatatacc tgacagtgcc ctttgccaat
     1621 atgatcatta ttagaatccc tacaaagaat atgaaagctg aaagaggctg tgaaataaaa
     1681 acagaactat cgtaaaaatc tttcagtcta taataatcag tatttacacc tgcttgttta
     1741 agcaggctgt taaccttgtc agtcctgaag atttcctcct gaaggctttg acctttcaaa
     1801 aatactgttt ctatggtcag gtccttatat cctgtgaggc tctcaaacgg aacatagatt
     1861 ctttcaactc cgtccgaaga taatattgaa aagggtctat ttttattctg gtaaacaccg
     1921 gtcaccttat atttaatccc tgaaatttca acttcatttc ccagaacatt atttgtcata
     1981 tacaatttct cagccaaagt ttcacttatg actgcaactt tttttccata ctcatgctga
     2041 ctgccgttaa agaatgagcc cttcagcatg cgaagtccta aaaagccgga caggtttcgg
     2101 ccggatagca ccctcttaac gggatacccc ttacttccgg cttttatata ggcctctgct
     2161 tcacattgat aggaataatt caagccggaa cgatttatta aggactcaag attctgcagt
     2221 tttaatgttc tgccttcagg aatcaggtta ttttttatat tgacttcaat ccttttccca
     2281 taatccccgt caaatttata ttcatacccc aaagccatac tgtttatgac aaataccagg
     2341 cagtacaggg ctgataaaag gactaataat ttttttaccg aatatcttcg taatttaatc
     2401 tcatccaatc cattcacctc aacttaacct ggagtccgtc agaaagtgct ttggagctaa
     2461 acacaactat cttttcatca cctgcaaaac cattcagtga tacggcactg tataagtcgg
     2521 cctcctcctg cactgtgatt tccacttttt gaacattagt ttcggtcccc aatacgcctt
     2581 ttctttcctt taaaaggaat acgtattttc ttccgccttc gtccactata ctgctgtttg
     2641 gaacaagggt tttgtactgc cggctttccc ttctgacttt gacatcaacc ttctggccta
     2701 ttttaaggtt ttccttggaa ttctcaaggt aagaggtaaa ttgatacttg ccttgttcgg
     2761 tcagatattt tttgtccttt acttttccgt tgaaattaaa attttcatca gcttctcccg
     2821 aaatctcaac agtatcgttt atctcaacct caccggcagg tttggtctcc agcgtccacc
     2881 tcacagccag gcccgattct ttttttacta tctcgaacaa tacctgcccg ctgcctgtaa
     2941 cagagccttt ttcgatggat atgcttttta tggtgcctcc gacaggcgcc tttataattc
     3001 catccatggg aatgttattt ttcatcttct gaagctcaag ctttccaacc tcgagttcgg
     3061 attctttttc cgctatattg atgccatagc tttctcctgc ttttttgatc tcggtttctt
     3121 tctgggataa agtcctttgc ttttcattat attcgcggtt tgccgcatcc agcttatcct
     3181 gggcatcatt tacctcctgc agcgaaacgg catcaacagc atagagctcc ttttggtcat
     3241 ccaggttttt ctgggccttt tgcacagcct tcagtgcggc ctcgcagtca ttcctgtact
     3301 gctccatatc cgcttcctga aagccgtttt tatatctctt gagttcattt tccagcttct
     3361 gcacattcag ctcggccttc tttatgtcaa gctgaaggtc cctgctgtca attacggcaa
     3421 gctcttcccc cggcgctacc tcctgttctt cctccacctt tatatccctg accttccatg
     3481 ttccataagc ataaacggct tcggtgccca cagggaaaat ctctccttcg gcggttattt
     3541 cattggtgag ggtccccgag gaagcagtat cacattctac ggttggcagc agaaaattat
     3601 ttatcgtgct tgaaaaaaag gttagcagga ttatgacaca tatgaaggca accgcagtcc
     3661 ttctgattat tttttttctt tttaataatt gactctctgt ctgaatatta tccattatat
     3721 cctccaaaaa agttgtcatt tgataccgga cagttcgatc ccctcaataa aataattctc
     3781 cccatataaa aagatcagca gggtggggaa catatacaat attccgcagg caaaggcaat
     3841 accgatatct tcgctgttta ttctggacag gaatattgac agcggatgca tggtttcatc
     3901 ctttagaaat accagcggct gctcaaccat attccagttg tcaatgaaga caagtatggc
     3961 cagtgaggct attgcgccct tgcattgcgg cagcagaatt gaggtaaggg atttccagta
     4021 gcctgctccg tcaattttgg cagcctcgca ataatcgtcg ggtatattta tcataaactg
     4081 tcttaatagg aataccccaa aggtggaaaa gacccccggc aggataatgg accaatagga
     4141 acctatcagg ttggtcctgt ccaggatgat atagttgggt acaagggtta cctgatacgg
     4201 catcatcatt acaataatat atatgtagaa aatcttgtca ctgaacggga atttcagctt
     4261 ggcaaaggcg tatgccgcca ttgttgctac cacaatctgt cccagcatta tgggcacagt
     4321 gaccataact gaattccaga acataaagag gaacctgggt ttccgcagca gcacgttgta
     4381 atattgcatg aagcttactt tttcaggtat caggctgaag gttatcccgg gagtcctccc
     4441 ttcctccacg gccgccccgc tgaccgcgct gtagttctcc attacctcgc tgcttgacat
     4501 gaaggaattt gcaagcatat acactaccgg aaacagcagt gctgcagaaa tacaaagcat
     4561 tattatgtac tttaccagac tcttcagttt aattcccgat ccggctaaaa aattctccat
     4621 agttttcatg ttaaatgctc cttccaaatc tggcttcaat tttgaaaaca ataaatacca
     4681 gtaatgctat tacgactgcc ataatgaggg ccgctgttgt aagcctttga taggaaaggt
     4741 tcataaagtt gttattcata aaatgctgga gcatgtaaat tttaagactt ggatagctcc
     4801 ctgcgagcag ataggcctct ctgaacacct tgaaggagtt tacgattgac atcattaata
     4861 cgaaaaaacc cgttggtatg agaaaaggta tggtaatgtt ttttatgcag gccaaggggc
     4921 cggccccgtc catacgtgcc gattcataat attcctttgg tatattgctg agacccgcca
     4981 gaaataatat tacgttgtag ccgcaatttt tccacaggta cagaagcacc agcacccaca
     5041 tggactgatc actttttatc cagtctatat tcccggcaaa cccgaatttt ataaggatac
     5101 tgtttattac cccatattca ttgaaaagaa tattccaaac aagaattaca gatgccacag
     5161 gtattaccag cggcagtata aaaaagcttc taaataccgg aagtcccttg atacgactgt
     5221 ttaaaagcaa ggacagcaga aatgaaagga taattatagc cggaacgctt atggcattaa
     5281 atatgattgt gtttttggat gccagtaaaa aagaattgct gtgaaacaga tctataaaat
     5341 tctgaaatcc tacaaattca atcccgccta ttccctgtgt aaaacagtag tatatgctga
     5401 ttgcaaaggg tattgcaaag aacagggcaa aacccgccag gctgggaagt gcaaaaataa
     5461 agcctgctat ggattgtctt gttttaagtt ttgtttgtaa cactgtcatt tcctacctca
     5521 tctttggtaa acaagctttt tatccaaaca aatattttta ccataataat tatataatac
     5581 tacaacaggg atatctacgc ttttattcaa gtatttgtaa acttttgatg aatagcggtt
     5641 attaatcgaa cgttttgttc aggaaggccg caagtagtaa ttatattaaa agcaaaacat
     5701 aatcactcat tcagataaat ggttattcta tcgtcaatag tttttgctgt accgccggct
     5761 gatttatttc cattaagaaa ttcaggcaac tcttcttcaa taattttata tacttcgttt
     5821 tcatataact taccgctgcc gacatttgcc cttattttat ccatacggtg tgccaactgc
     5881 tcagtcaagg gaatattccc taaaacagta ttactattta cttaagcaaa attttttatc
     5941 tagattatag gcactttcac ttaccggagt ataccaattt gggtcatcct ttccggcctg
     6001 ctgttggtat tcatctgaaa gcagcagctt tataaatgca aaagcatccg gtttgctttt
     6061 acattttgca tttatactta acaaataata gggccacacg gtgttgacat ctcctttgtt
     6121 ccatgttgga aatgcaaata ttctcacctc ctgcttatta aaaagtctgg tgatttgatt
     6181 atatgcttca taaagggaat acggactata tatccctgca gtattcacca tcacaacggt
     6241 accatttttt aataattcgg tataagaata tttgcttgaa atcctgcctg gacaaattgc
     6301 cggataaata tccttataaa aatttagtac ttcaataaac tcctttgaag catatgacgt
     6361 ttttttcttg tcatagtcta taaacggatt tcccaaagaa caaaggaatt gcgtaaaact
     6421 aaggctgtta ataaaatact tacctttgga tttgttgtca gcaatgaatt ttttcactat
     6481 ctcggcaaca ttattccaca tcaaattgtt ttcatcaagt ttaatattat ttttatttaa
     6541 tatctcttgg gtagtaagaa agcctgaatt aacgtaatta attggaataa gatatctttt
     6601 ccccgcatag acaccgtaat ccagaatttt ttcgttgtaa tccgacagtt tgaaatccct
     6661 atcttctgta ataagtttgt ttatgtcata aaatactccg tttgaaacaa ctttgtttgt
     6721 attgcttaac atatcaagtc tgtttacaat aatatccggc ccattccctg ataaaagacc
     6781 ggtagtattt ttgttcttaa actcctgaat gtcggaaaat actttagctt caatttttgc
     6841 atttgagttt actttattat acttatccac cgcatttaat agggttttgt cagaatccat
     6901 caagtaaata gtcaactgag actttgaaga gtttgtacta ttattctgct ctgaacagga
     6961 gataaggttt atcgaaaata ccattattaa taaaataatg tttattttct ttacccggac
     7021 attcatatta tgttgaaaat gcaaaatatt ccaacctcct ccgccttggc ccaaaaattt
     7081 accttgcctg acaatgtact tttttatatg ttacaaacta ctaagtcgat tcttaccgga
     7141 gctttttgtt aagccttatt cattcaaaaa taataacact ttttcattta ttgcttttgc
     7201 agtctgctcg gcacttttac ttccgtttaa gaaatttatc atttcatcat taataattgt
     7261 taaaacactt tggtctataa aattgcaagt attaaccttt tcaggtatat cttctaaaat
     7321 tcttgccaaa tcttccggta tcgctttact tttataggtt ttatcatctg caggattttt
     7381 tatatctttg ccccgttttt cctcacttga atagtaagct ataatttccc tatatgcttc
     7441 tttatttaca ggagcacttg aaattacagt atctttttga atttcttttg acaaaacata
     7501 ttttataaat tcaaatgctt cttctggatg cttacattta ttacttattg cagtgaattt
     7561 tttaacatat gcggaataat taccattatg ttgggatgat ggataagggt atatttttat
     7621 atctgaatta agaacatttt tcccaaaatt atactccgtc caaaaaaatt caggattggt
     7681 agaatatgtt tgtagtaaaa tgagtgcatt atcctttacc attccccagt ataaccccct
     7741 gtatttcata gcatattctg gaggacaaat tgtaggaatt atatctctat aattttttag
     7801 taagttaata aattcatccg aattaaaatt tgccttttta gatttgtagt ccacaaagct
     7861 tttgccgtag ctttcgaaaa tagtttgaaa atccattgga acaaaaaaat actttccttt
     7921 attattattt ataaactgta atgaaatttt tgaaagcatt tcccaagaaa aatttttatt
     7981 atctatgttg atattattgc tctttaagat attatcaaat ccgtaaaaaa tatgtacatc
     8041 aaaatttgtc ggcaaaatat atcttttacc atctattaca ccacaattta gtacttcttc
     8101 gtaataatca tccaacctaa attctttatc ttttttaatc agtttattta agtcatagaa
     8161 tgtcttattt tggatcgttt tgtaaatgga agggaatatg tctgtattat cgcagaataa
     8221 atcaggacca ccacccgcca ttaaatcagc agttaatttc tctgagtatt ccttgtttat
     8281 atataaagga atatcatcta tcataagttt tatattttta tttttagcat taaatttatc
     8341 aattgcatta tgtgtagttt gatcgtttac acgaacactt acttcgagct cgattttttc
     8401 attttgcctc ttattatcga tcacttcatt agtttcacaa ctactaaacg taatcatagg
     8461 gataattaaa agaagtagat aatgttttct cataattgta cttatatacc tgcattaaaa
     8521 cgcattagta taatcctcca ctctatcaat ttaatagtac cttttttata atccattctt
     8581 tgttttaaac ttggactgtt atagctaaat tgtttaatat ttatgacatt taaacatttt
     8641 gaattgtttc ttctctattt tttttcaatt gtctatcaat cagattaatc atcctattta
     8701 atgttttaaa ctctccacta actatatcct tctcaggtat tgtaatatta aattcgcgtt
     8761 caatatcaaa aaacaggtaa acgagatccc ttggctcaat gccaaattgt ccactaagca
     8821 tatcagtatt aaaatctact agagatatat caagtcctaa cctttcttca aaaatacggt
     8881 ttaaaattaa gtaatctaca gatttcatat tctaactcct ttaaataact aatttgtaaa
     8941 caaagaatac tctccataat aactaagttt atctattatg gaagtagcaa tttccttaga
     9001 atcattgcta ttgaatatat taaatagcgg gatttttaag tctttataat tttttagctt
     9061 cttatcgata aaacttggat ctatggtcaa gtattccagt tcagtgaact cacccgcatt
     9121 tggccaatgg cactgcacat ttgacaaatt aaagcagtcg atttcatatc caaatttata
     9181 ctttaatgca gtcgaaattt ttttaaaata ttctggtttg tagttttcat aaaaagagct
     9241 taccaataca aaatccggtg ttaatgcttg agaaacttcg taggcaataa taccaaaatt
     9301 gtgagtatat tcattattta atttcattgt acctccagga atgccaataa taattaaatc
     9361 tggtgactct tctatttcta tttcttttat aaatctgtta aagctaataa tcttttctgc
     9421 ttcactaatc gatttatcaa acataaagtt agggaatgaa tggaatccca ttagttcaca
     9481 atattttcgt gatccgacct gagcaacttt atatcctaaa cgtttgattt cttctctaat
     9541 acttaactgt atttcgaact tacatgttct ttcacccatt cccattacaa atactacagg
     9601 agtacctatt ctatatagat tctctttgaa aattaaataa cttttttgtt cacgatttat
     9661 acaactttga taatgaacac cgtattcttt acataattca gaaataatat catttctttt
     9721 atcatctata tccattacag atataatgtt tttcttatgt tttattgctt ctaaaatttt
     9781 cgaaaatata aattcattgt agtcaatact tagcaaatta tcacaaatta ataccgtgtc
     9841 acaacattct aataataatt taaatttatc cattttttga atatctattt tccctttatt
     9901 gaaactacaa taattgtcct tatgcccaaa tgtaattcca cctataatct caaacttgtc
     9961 caataatgaa tagtgattta aaagcggaat aatttcaaaa ctataaggaa atatcaacag
    10021 tttttctctc attttgtcct cctataaatc tattaaactc atatttcatt tgctttagca
    10081 tacatatatc tttcagtcta tcttcagcaa atttcatagt gccattgcac ttacttattt
    10141 tttcatattt tgacaatcca tttactgaat cagccatcgc agcacatgat ccacagaacc
    10201 taaatgccca gcagttttta cacttatctt cgcttaattt gccgatgttt aatatttcac
    10261 gaatattatc ataattaaaa ccatcaaaga cattaccaat tttcattatt tccgatgtct
    10321 cactcactct ttcacaagga aaaagggttc cctgcgtatc aacaaataac ctttgtgatc
    10381 caggaataca aggtcctcca tgatgagctt tttcaggtaa tttttcagtt actttaagtt
    10441 gtgcataggt tttctctaat gaaataaaat atgtccttac aagttttgaa acataacttt
    10501 gatccaatct tccaagttta gataaaaaca gtttaaatat ttcatatctg taattattta
    10561 taaacgtctg gtcatttttc accagatctt tctttaaatt aggatttatt tctgatgcta
    10621 aaaccactgc ttctttaact aaatcaaaat ctttaaaaaa attgtcaaca caacaaaatt
    10681 cattttcctg atcaagtact gcattaaagc atatattttt ataataatca ggatattttt
    10741 gtttgattaa atttacatta ctcattacaa tttcgaatgt gctatcactt gtacaagcaa
    10801 attttctatt tctatcttgt acctcttttg gcccatctaa acttatcacc aaatatacat
    10861 cgttttcttc aaacaactgt ataatacttt cattaagtag tgtaccgttt gtagttattg
    10921 taaaagataa cttcttgcca taggaatttt gtttagcata tttgatacat tttctcatta
    10981 attctttttc taacaatggc tctccaccat aaaacccgat atttatttct ttattatctc
    11041 cagaatgttc gagtaaaaaa tctatacttc gcttggcaat ttcaaaatcc attctacttt
    11101 ttgtatgtgt tctattatag tagcctcctg aatatgcaca atagctacaa tttagattac
    11161 agttttgtgt aagctgcaat gttatcttct gaattttact atttaaataa tattctataa
    11221 gttcatctgc aggatgtaaa atttctttta ttttatttga ggaaaaaaat ccatcatttt
    11281 tcatttttgc taaaagatca actatataat tgttttctac attatctaat gatgtttgat
    11341 ctcctaccaa cagctttata agttcattct gcccttttaa aataacattc ctatttacat
    11401 catatatata atctttgcca ccaactctaa atgtatgaat aaatggttta tggctataca
    11461 tgcctatttc caccttccac aatgttaata aaaggaaaaa ttgaatcaac ctagcttttt
    11521 agttgattca attttttcct aactacatat gtaatattat ttgttacatc taaccgacag
    11581 aggcaacact tccactatac gatgatgaat ctgagtgatt atcagttcta gaaattgata
    11641 agctgccata aaaccaactt tgaacagatc cataagcatc acatgaacca gaacaatcac
    11701 aagaacatcc acaataggaa catgaagtac aataagcttc tactgtctcc atctggaatt
    11761 ctagcttttt acctagactt ttcatttttt tcaccacacc ttcgtatttt ttatggttca
    11821 aaagctcgcg aatttctttt gaacattatt tatttgaatt tccatcaggc tttccgcggt
    11881 tacctatcaa gaaatcaaat actccccctc gtttagcaaa agaatcttat ttgttctctt
    11941 aaagatatct ggtctatgac ttactaaaat tgcttagctg attaaaacta aagtaaacat
    12001 aataagtgat aatcttaata caatatcaaa atctgctata agcaatcttt tatccataat
    12061 cccccctact gagacagttt aaataatctt gtaaaaattg ttttagcttc agtattaagt
    12121 aacattttac cctcatgtta aaaatattgt aaaacttttc gtaataccga aaatacttta
    12181 tttagtagtt aatgaattat gctctttttt atataaaacc gtttatattg gatagtgttt
    12241 cgccaaaaag ataaatattt cgtgaaagtt tcagttaaaa tatttttatt tcaatcatat
    12301 ttttgctttc tttgaattat tctacaccaa tatatcccag atatcaacca tttttggtat
    12361 tttttatcaa tttgcttttg cattaaaaat tcttcttaaa gttataaaca gtttttaact
    12421 tattgtaacc caaatgaaat tcaacctagt actataattc attgattagg ctttcgcaag
    12481 gacgaacgaa ctgggccttt taaattacta cttgcttaag atttataaaa atggtgtgaa
    12541 ttttataaat ggattgttgt tattcaatcc aaaaataata tttgcctgac tccaagtaag
    12601 catctcagct atcagggcct tttacaaagt tatgaattat ggagtatgcc tagatcttcc
    12661 gcttcaacct atataaatta catatggatg gctgtaacat ttttacctta tttatgaatt
    12721 ttatttaata attttaaata ttctcttttt ctttataatt tttatttgtc aaggtttaat
    12781 tctatacttt acaaatataa ttaactttaa attgtgtata ttttcagcat tagctggtat
    12841 atttcataag ccgctattcc caggatggcc agcagtgcgg caaaagcata aattccccat
    12901 gcggtatggg tattcagggg atttattttc ttcttttctt cctcaaacag ccttttgctc
    12961 ttctccctgc gttcccacca attatagatg cagaaacaca tcagcaggag cagcacaaac
    13021 aatattaaaa tcagctttcc catatgtccc tcacagataa atattctttt cccgccgtaa
    13081 ataacagccg ggttacatca ccgatgccat atcctgatat tctgccgcgg tttggcaacc
    13141 cggcaggata tcaggcctta ctaacatttt acaatactct tttgaattag tatacactat
    13201 aaataattcg ctgtgccgga taatcactcc tcaactttgc agctataaaa cttccttcaa
    13261 aaatctgcct gtatgtgagg ttttcacgtt agccacctgt tcaggagttc cttcggccac
    13321 gaccatacct ccgccgctgc cgccctcagg gcccatatcg ataatgtagt cggcagattt
    13381 tataacatcc agatggtgtt cgatgaccaa tacggtatgg ccgttatcaa caagtttaat
    13441 aaggcagtct ataagtttcc ggatatctga cagatgcagc cccgtcgtgg gctcgtccag
    13501 aatatacaga ttatgcgcac ccctctttat ctttgacagc tcgtatgcca gctttactct
    13561 ctgagcctcc ccgcccgaca gagttgtgga gctctgccca agcgtcatat accccaggcc
    13621 gagttcgttt atgatattca atttatgcct caggtatttt tcgtccttga agaattccaa
    13681 tgcctcttcg gctgtcatat ccagtacatc cgcaatactc ttctgtttgt attttatctc
    13741 cagtccttca tcggaaaaac gtcttccttt acaaacaggg catatggttt caatatcggc
    13801 cataaactga aggtttgtca caatgatccc gtccccggca cagtgttcgc acctggtgcc
    13861 gttggcatgg gtcagactga agtcaatttc gctgtagccc ctgtgtattg cctcaggctg
    13921 gtttgcaaag atctcacgta tcttgtcata aatgcctata taagttgcag gatttgattt
    13981 gctgttcttg cctatgggag actggtcaat attgatgaca ttgtttaaca gttcggttcc
    14041 aaacaagaag tcatgctctc cggcaactat cctggcacca gttttgttga ttttcagctg
    14101 cttatacaat atttcgttta taagcgaact tttccccgaa cccgaaactc ccgtaataca
    14161 aataaaaacc cccagcggta tgtcaatatc cacatcttta agattatttt cacgggctcc
    14221 ctgtatggac aggaaattat cacccaggtt tctccgatga gctggtacag gtatggatgt
    14281 cgaccccgac aaatactttc ctgttaccga agcctgctct ctcataatat cttcaaccgt
    14341 acctgaagct acgatattgc ctccatgaac acccgggccg ggtccgattt caattatatg
    14401 gtcagcactc tttatggtgt ccatatcatg ctcgaccaca attacggtgt ttccgatatc
    14461 cctcagcttt ttcatggtgt cgattactct ctgggaatcc ctggggtgaa gccctatgct
    14521 gggttcatcc attacataca gcatgcccat cagttcactg ctgatctgtg tggacatttt
    14581 gattctctgc atttctccgc ccgaaacact gtcacttctc ctggcaagac ttatatagtg
    14641 caggccgata tctatcagca gttcaagtct ggagctgatc tccctgataa cggattccgc
    14701 aatttcccgt atatcctctt caaaggtcag tgacttgaga aaatccagca gttccggcag
    14761 ctgcatcctg ctcagctggt caatattcct accccctacg gttatgtgga gtctttgcct
    14821 tttgagtctg gctccgttgc attccggaca gattttttct atcatgcatt cctttataaa
    14881 ggtgggttca aaggcttcac ttgttgaggt tttccttata tagtgcctgt accagctctc
    14941 caattcatgg acgaaacctg caaaaggcct ggctcttccg gttatccagt ttctcttctg
    15001 ggagtacgga ggctgcagca tttcaacagg ctctcccttt gaaccgtaga aaagaagttc
    15061 atgaatttcc ttgggaagat ccctgaaggg aatatccaga ctgaaattat atttttggga
    15121 caggctgtac attactaccg agcgataact gtccttgttg ccgggactgt acaccgtatt
    15181 tctgagagcc cccctgttca agcttttttc aggagaaaca atcaaaaacc tcggttcaac
    15241 cacataggac attcccaccc caagacaggt gtggcatgca cttgcaggcg tattgaagga
    15301 aaaatggaag ggctgcattt cacacagtat gtggtggtgc tcggggcagc cgaaaccggt
    15361 atagaattcc ctgccggcat ttccctccac ctccactttc agcataatgt cctcatcaag
    15421 ggcaagcatg gccgcctcaa tggattttgt caattgaata tatgtatcgt ttttcaaagt
    15481 gaacctgtct attaccagtt caatcttata ctccacattt tcatcaagtt ctcttttatc
    15541 ggccaatgaa aaaggctctc cgtcgaccag caaattctta aagcctttct ctctgagctg
    15601 gtggaaagta taatcatagt cctctccata aatcttatat accggtgctc tcagttcaac
    15661 aaccgtaccc gcaggcaaag ttgaaatatg ttccgctatc tgggcggcag acaattgttt
    15721 gagctgatgc ccgcattcag gacacttccc caccccggca gccgaaaaca gaagcctcat
    15781 atagtcattg atgtctgtaa cagtacccac tgtcgaccgt ggattgttat tgctcttttt
    15841 ttgttcaatg gcaataaccg gagacaatcc cctcacataa tccacctttg ccttttttaa
    15901 ttggcttata cggctctttg cgaaattgga tatggaatcc agaaaccttc tctgaccttc
    15961 accgtatata acatcaaaag ccagagagga cttacccgat ccggatactc ctgttatgac
    16021 ggtcagcttg tccctgggga tatcaacaga tatatttttc aggttattct gttttgcccc
    16081 cgatatttca atatgtgttc tgataggcat tctttatctc ctttcatctt ccaaaaaata
    16141 gttatcaacc catgacagcc gcgttacggc accagcaaaa atccctgttc ctccactgcc
    16201 agcttgcttt taggagttat ccgtatagtc tgggacaccc tttcaattac gcccttatcg
    16261 gcaagatagt caaatacatc aattatataa tgactatcta catgaaaatg ctttgcaatg
    16321 agagtgctgg tttttatttc attatcaccc ataaattcaa taacgggttt ttgtatgatg
    16381 tccagcttgc tcataagata tccgtcaatt ttatcgatgg ccgcttttag ttcttcaatg
    16441 ctgtagcagc gggacatggc ctcctgataa aatgtcttaa gcaggtctgg attaagtgcc
    16501 gccgctttct gtatggattc gcgggaagcc ggaataccgg ccaggcacag ctccatgttt
    16561 gcaataactt ctgccgcctt caggatataa tactgggtat aaagaggatc ttccctggcc
    16621 gtaagccact tttgacactt gtcatagatg cctatgagtt cacctgccat ataaaatacc
    16681 gacagcgcaa tatcgtcact tcccataacc ttgatatcct caaaaaagtc atataaactt
    16741 tcatctgtgg tgtagacaat tttccccttc gaaaaatatg cctgcatgaa agaccctccg
    16801 atatttcgtt ccatgtatct tctaaaggag cttctgacag taatgtaaac attaattgta
    16861 atgccgtcct caatgatgga atagctgtcg tttttcagat tttggtcacg tactaccaga
    16921 gtcatgtcga tatcactttt ttcccatatc atatcgtaag ccagacttcc gctgacaatc
    16981 accgcgatga cattgggatc acccttgatt ttttcaacaa agctgtccac agctccgtta
    17041 tatctttcct ttagttcggc ctgacgtttc tcatccatgt tcggactccc ttcactagta
    17101 gcctgtaaca tctaaattca tatttagatg ttacaggcta ccaggctttt ataaataaat
    17161 ggttgttgtt aaaaaaaggt tattgtatga ttatacttaa tcccatttgc aaaaacagga
    17221 caaaaattgc ggaggttaat gggacgattc ctttgtctca ttggggaaat ggaggctgat
    17281 ttggacaatc acttgctgga gttaataaaa gaaaccaccg gattcataga aaataatctt
    17341 ctggaaccgt taaacctaga taatatatca gaaaacgtca atgtctccaa gttccatctt
    17401 ctaagaatat ggaagggtgc cactttcaca ggtttaatgg aatatgtccg caggagaagg
    17461 atcgcccagt ccctgagtga cttgatccat gaaagaaaca gcatagaatt catttcatca
    17521 aaatactcct tcggcagcga acgtacctac aacagggtgt ttaaggaaga gttcggcata
    17581 actccggcaa aatggcgcaa aaatccctgt cccctggaaa ttctggacag gtttaatgcg
    17641 gattttatga attgtgccgg agaagggctt gtctttctcc gttcaataac cgtgctgccc
    17701 gccttttcaa ttgcaggtct ggaatacagg gttgaagtgg aggataatgc ggtcaatcag
    17761 acagcaaaca agctgggtgt ggatttcttt tacaatcaca ggctcagagt ctttaatccg
    17821 gtggaaaaag atgtatatat cggccttaca actgttccgc cccatgcgga agggtatacc
    17881 ttttatcagc cctcggtagg gattgatcag agcagcattg ttcctcccga tatgaaaata
    17941 aggaatatcc aaccgcacaa atacggagtt ttcacataca tgggccccca caggccggaa
    18001 gacatctctt caaagacttt atcaggaata tgggaatata tttttaccac atggatgccc
    18061 aatgtggatt ttaatcttaa acagaagttc cgttttgaac ggataaatta cgcaaaatgc
    18121 agcaagcagt atagtgaatg tgatttatat tatcccattt cctacatata gcctgtattc
    18181 aatctttaat tctgattaat ctttgtttgc gtcagtttca taatcgtact cgtgtttggc
    18241 aaataaacct gtaatgtaag aatacaatcc gtctatttcc aaatcacctt gcagagcaaa
    18301 tgtcctggtc tcattagagc ttttaatttc aatttttaag ttttcataaa catttatatt
    18361 aatatcagtt tcaaaattgc cttccatatc atttatgcaa ttctgtttat gctgatttgc
    18421 catatcaacc gatacaagca taatatccgg atcaaaaaca ttaaatatcc tctgtagtgc
    18481 cccggttata aaatcacctt tattttcaat aaaactgctg atgtttatgt acccggcgca
    18541 ataatcctgc gctgtctttc cttcaaaaat acttattgca ttgtacccgt ccttcctgaa
    18601 tgcatcggta agctttctgc ccaaatactc ggattccttt ccgcaataat tatacagtgc
    18661 aataaccgga gcatccatat ttctgtccac catgctgtaa gaggtatgat tgcagggcag
    18721 ggattcctcc ctctcaatcc tgtcagtaag tattgatgct ttccttaatt tttctctaat
    18781 atcaggcaat aaaatatcgg gattatttct aataatttcg tacaccaaag cagtaatgag
    18841 aggtgcggca tagctgttac acatggaagt ggttttgctt tcaccgttaa atttcttcag
    18901 tttgtgacat ccattagcag ttatctctat tccgtcaggt gccttctgat tgtaaatata
    18961 ttctttttcc ccaagcttat cctgacagtc gcacctgact cctataacat ctcccagtga
    19021 agccggacag gtaaaaatat ttctgttatt acaggcggca actattacaa cacctttttc
    19081 acgagcatag ctcacagact ctcttatttc attaaaatcc ctgtaatcta tagttccaag
    19141 gctgagattt accagcctta taccattgtc tgcgcaccat ttcaaagctt tgatcaattg
    19201 agccttcatt cccgtatgtg attcaccatc taaaatcttt atactggaca gaaccgtctc
    19261 aggagcatat ttattaatta tagcggcaca ggtggtcccg tgtgacgtca taaaggggtc
    19321 ataatcaacc ctttcacata ttttcaattc aggtgtcacc tgtatgttat gtttaagctt
    19381 gcctatttta tacagctttt catttacacc gtcgtcaata attgctatat gtgttttata
    19441 catatccaaa cgtatccttt tccttattta catttagtag ttattcaaat attactgatt
    19501 caattaaaaa tcttatgtaa agcaatgtgg ttttcgttga gctttattca ataatatatt
    19561 atattaatta tacaatttct attaaatttg taaaccgata ccatgaaatt aataaaagcc
    19621 cgaaacctgt tcttccagcg gttaagggct ccttttatca aaaattgtag tttctgcggt
    19681 tccattcgat tgtcctcatt agcccttcac tcatcggctt gaagttatcc aatccgaact
    19741 ccgaacatat cctctctata cacagctcca catgctgagg agaaaccttt accttttcgg
    19801 caaagttgta ttcggagttc tccacagaaa gcttgctccc ggtgatggcg catatctctt
    19861 ccgcaagctt tcgaatggtg atgctttcct ttccgcctac gttgtaaacc agctgagtgc
    19921 cgtacagcat aacattgagc agcattagta cgcaatcggc aatatagcag aatgttctga
    19981 ccttgctgcc gctgtccatc ataatgattt cctttttgtt gagagcctgc cttataaact
    20041 gggttaaaac acgttcatca ttggcactga ccccggggcc ataggtcatt gatatcctgg
    20101 ctatcttcgc attgacattt tcatagttct tatatgcaaa gcaaagagtt tccccgatcc
    20161 gcttggcctc cgagtatatg gatctgatgt tcacgggtga gcacagtcct gggaactcct
    20221 cacgggtggg tatgttatcc gcatcaggct ccccgtacac ttccgatgaa ctcatataca
    20281 gaaaatccgc attgtttacc ctggccttct gaagcagctt ttctgcaacc accgtattca
    20341 aatgtattgt atccagataa tttcttagaa atttgccagg ctgtgcatat gtggccccat
    20401 gaatgatata gtcggctttc tgcagcatat ccagcgagtc gggcaaattc agatccagcg
    20461 gatgaaatct gtaattactg tcaaacactt cgcttaaggc cttattggga gtgcttctgc
    20521 tgacggcctc aatatttatg cctgtgccgt ttaccacatt ggagatatga agcatatata
    20581 tgagataggt gcctatgagg ccgttagccc ctgttatgag cactgttttt cccttgagag
    20641 gtgttaaatc aattcgtgta atatattccc tgcagtcctg ttccatatat ttatccaaag
    20701 cgtgttcccc ctttatttca gaatccccct gactgcgtcg catatggtct cggaatccgg
    20761 ataatatgcc ttttccagta catcactggt gggcgtcgga caatccggac agcaaactct
    20821 gacaataggc tccttcaaat agttcaatgc cttttcagaa acgattgcag ctatctctga
    20881 ggctgcccct ccggttcttg ggccggtgtc ggttattatt agcctgccgg tctttgccag
    20941 ggattcaaaa atgacttcct catcaatagg cttgatggtt ctaaggtcaa tgacctcggc
    21001 cgatatattt tccgcctcaa gcttcctggc agccttcagt gcttcgataa ccatatagga
    21061 tatggccact atggttacgc tgctgccctt ttttcttacc gcaccctttc cgaaaggtat
    21121 ggaataaaga gtatcgggga ccttacccat ggttttatac aaccacctgt gttctacaaa
    21181 aaggaccggg ttgtcatcaa ttatgcttga gatcattagt cccttggcat catatggcgt
    21241 tgcgggcaca gctattttta gtccgggcac attcataagc ataccctgga tacactggga
    21301 atgctgtgca cccgatcccc agcctctggc gctgatagtg cggaccacca gcggcacgct
    21361 gaccgctcct cccgtcatat aactccactt tgccgcatga tttaccagct gatcaaagga
    21421 cagcagcagg aaatccatgc gggcatgcac caggacaggc c
//
