Select genomic region:
Overview
2.1
2.2
3.1
3.2
3.3
6.1
7.1
9.1
11.1
13.1
16.1
16.2
21.1
22.1
23.1
26.1
30.1
33.1
51.1
60.1
67.1
68.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JHYD01000002 (original name was: NZ_JHYD01000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 82,007 | 129,467 |
Region 2.2 | ranthipeptide | 320,657 | 342,087 |

NZ_JHYD01000003 (original name was: NZ_JHYD01000003.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 3.1 | ladderane | 31,878 | 75,918 |
Region 3.2 | NRPS-like,NRPS,T1PKS | 203,951 | 260,810 |
Region 3.3 | NRPS | 267,826 | 316,824 | equibactin | NRP | 21%

NZ_JHYD01000009 (original name was: NZ_JHYD01000009.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 6.1 | RRE-containing | 176,519 | 197,958 |

NZ_JHYD01000010 (original name was: NZ_JHYD01000010.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 7.1 | cyclic-lactone-autoinducer | 29,251 | 49,968 |

NZ_KK211292.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | NRPS,T1PKS,transAT-PKS | 137,152 | 208,504 | microsclerodermin M | NRP + Polyketide:Modular type I | 27%

NZ_KK211293.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 11.1 | RiPP-like | 141,533 | 152,348 |

NZ_KK211295.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 13.1 | NRPS,ranthipeptide | 1 | 59,208 |

NZ_JHYD01000025 (original name was: NZ_JHYD01000025.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 16.1 | ranthipeptide | 58,417 | 79,877 |
Region 16.2 | cyclic-lactone-autoinducer | 85,211 | 105,777 |

NZ_JHYD01000031 (original name was: NZ_JHYD01000031.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 21.1 | ranthipeptide | 4,590 | 32,599 |

NZ_JHYD01000032 (original name was: NZ_JHYD01000032.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 22.1 | cyclic-lactone-autoinducer | 67,934 | 88,557 |

NZ_JHYD01000033 (original name was: NZ_JHYD01000033.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 23.1 | cyclic-lactone-autoinducer | 18,940 | 39,533 |

NZ_JHYD01000037 (original name was: NZ_JHYD01000037.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 26.1 | NRPS | 41,446 | 85,792 |

NZ_JHYD01000041 (original name was: NZ_JHYD01000041.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 30.1 | betalactone | 1 | 20,690 |

NZ_JHYD01000045 (original name was: NZ_JHYD01000045.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 33.1 | transAT-PKS-like,NRPS | 14,074 | 55,758 |

NZ_JHYD01000063 (original name was: NZ_JHYD01000063.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 51.1 | NRPS | 1 | 16,139 | paenilarvins | NRP | 50%

NZ_JHYD01000072 (original name was: NZ_JHYD01000072.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 60.1 | NRPS | 1 | 4,656 |

NZ_JHYD01000079 (original name was: NZ_JHYD01000079.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 67.1 | NRPS | 1 | 2,215 |

NZ_JHYD01000080 (original name was: NZ_JHYD01000080.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 68.1 | NRPS | 1 | 1,880 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | NRPS | 82,007 | 129,467 |
Region 2.2 | ranthipeptide | 320,657 | 342,087 |
Region 3.1 | ladderane | 31,878 | 75,918 |
Region 3.2 | NRPS-like,NRPS,T1PKS | 203,951 | 260,810 |
Region 3.3 | NRPS | 267,826 | 316,824 | equibactin | NRP | 21%
Region 6.1 | RRE-containing | 176,519 | 197,958 |
Region 7.1 | cyclic-lactone-autoinducer | 29,251 | 49,968 |
Region 9.1 | NRPS,T1PKS,transAT-PKS | 137,152 | 208,504 | microsclerodermin M | NRP + Polyketide:Modular type I | 27%
Region 11.1 | RiPP-like | 141,533 | 152,348 |
Region 13.1 | NRPS,ranthipeptide | 1 | 59,208 |
Region 16.1 | ranthipeptide | 58,417 | 79,877 |
Region 16.2 | cyclic-lactone-autoinducer | 85,211 | 105,777 |
Region 21.1 | ranthipeptide | 4,590 | 32,599 |
Region 22.1 | cyclic-lactone-autoinducer | 67,934 | 88,557 |
Region 23.1 | cyclic-lactone-autoinducer | 18,940 | 39,533 |
Region 26.1 | NRPS | 41,446 | 85,792 |
Region 30.1 | betalactone | 1 | 20,690 |
Region 33.1 | transAT-PKS-like,NRPS | 14,074 | 55,758 |
Region 51.1 | NRPS | 1 | 16,139 | paenilarvins | NRP | 50%
Region 60.1 | NRPS | 1 | 4,656 |
Region 67.1 | NRPS | 1 | 2,215 |
Region 68.1 | NRPS | 1 | 1,880 |

No secondary metabolite regions were found in these records:
  NZ_JHYD01000001 (original name was: NZ_JHYD01000001.1)
  NZ_KK211289.1
  NZ_KK211290.1
  NZ_KK211291.1
  NZ_JHYD01000015 (original name was: NZ_JHYD01000015.1)
  NZ_KK211294.1
  NZ_JHYD01000023 (original name was: NZ_JHYD01000023.1)
  NZ_JHYD01000024 (original name was: NZ_JHYD01000024.1)
  NZ_JHYD01000026 (original name was: NZ_JHYD01000026.1)
  NZ_JHYD01000027 (original name was: NZ_JHYD01000027.1)
  NZ_KK211296.1
  NZ_JHYD01000030 (original name was: NZ_JHYD01000030.1)
  NZ_JHYD01000034 (original name was: NZ_JHYD01000034.1)
  NZ_KK211297.1
  NZ_JHYD01000038 (original name was: NZ_JHYD01000038.1)
  NZ_JHYD01000039 (original name was: NZ_JHYD01000039.1)
  NZ_JHYD01000040 (original name was: NZ_JHYD01000040.1)
  NZ_KK211298.1
  NZ_JHYD01000044 (original name was: NZ_JHYD01000044.1)
  NZ_JHYD01000046 (original name was: NZ_JHYD01000046.1)
  NZ_JHYD01000047 (original name was: NZ_JHYD01000047.1)
  NZ_JHYD01000048 (original name was: NZ_JHYD01000048.1)
  NZ_JHYD01000049 (original name was: NZ_JHYD01000049.1)
  NZ_JHYD01000050 (original name was: NZ_JHYD01000050.1)
  NZ_JHYD01000051 (original name was: NZ_JHYD01000051.1)
  NZ_JHYD01000052 (original name was: NZ_JHYD01000052.1)
  NZ_JHYD01000053 (original name was: NZ_JHYD01000053.1)
  NZ_JHYD01000054 (original name was: NZ_JHYD01000054.1)
  NZ_JHYD01000055 (original name was: NZ_JHYD01000055.1)
  NZ_JHYD01000056 (original name was: NZ_JHYD01000056.1)
  NZ_JHYD01000057 (original name was: NZ_JHYD01000057.1)
  NZ_JHYD01000058 (original name was: NZ_JHYD01000058.1)
  NZ_JHYD01000059 (original name was: NZ_JHYD01000059.1)
  NZ_JHYD01000060 (original name was: NZ_JHYD01000060.1)
  NZ_JHYD01000061 (original name was: NZ_JHYD01000061.1)
  NZ_JHYD01000062 (original name was: NZ_JHYD01000062.1)
  NZ_JHYD01000064 (original name was: NZ_JHYD01000064.1)
  NZ_JHYD01000065 (original name was: NZ_JHYD01000065.1)
  NZ_JHYD01000066 (original name was: NZ_JHYD01000066.1)
  NZ_JHYD01000067 (original name was: NZ_JHYD01000067.1)
  NZ_JHYD01000068 (original name was: NZ_JHYD01000068.1)
  NZ_JHYD01000069 (original name was: NZ_JHYD01000069.1)
  NZ_JHYD01000070 (original name was: NZ_JHYD01000070.1)
  NZ_JHYD01000071 (original name was: NZ_JHYD01000071.1)
  NZ_JHYD01000073 (original name was: NZ_JHYD01000073.1)
  NZ_JHYD01000074 (original name was: NZ_JHYD01000074.1)
  NZ_JHYD01000075 (original name was: NZ_JHYD01000075.1)
  NZ_JHYD01000076 (original name was: NZ_JHYD01000076.1)
  NZ_JHYD01000077 (original name was: NZ_JHYD01000077.1)
  NZ_JHYD01000078 (original name was: NZ_JHYD01000078.1)
  NZ_JHYD01000081 (original name was: NZ_JHYD01000081.1)
  NZ_JHYD01000082 (original name was: NZ_JHYD01000082.1)
  NZ_JHYD01000083 (original name was: NZ_JHYD01000083.1)
  NZ_JHYD01000084 (original name was: NZ_JHYD01000084.1)
  NZ_JHYD01000085 (original name was: NZ_JHYD01000085.1)
  NZ_JHYD01000086 (original name was: NZ_JHYD01000086.1)
  NZ_JHYD01000087 (original name was: NZ_JHYD01000087.1)
  NZ_JHYD01000088 (original name was: NZ_JHYD01000088.1)
  NZ_JHYD01000089 (original name was: NZ_JHYD01000089.1)
  NZ_JHYD01000090 (original name was: NZ_JHYD01000090.1)
  NZ_JHYD01000091 (original name was: NZ_JHYD01000091.1)
  NZ_JHYD01000092 (original name was: NZ_JHYD01000092.1)

Compact view
c00002_NZ_JHYD.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 82,007 - 129,467 nt. (total: 47,461 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.31 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001686.1 |  | 0.30 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000410.1 |  | 0.29 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000457.1 |  | 0.28 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000342.1 |  | 0.26 | NRP | enniatin | Fusarium equiseti
BGC0001873.1 |  | 0.25 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0000308.1 |  | 0.25 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000321.1 |  | 0.25 | NRP | chaetocin | Collariella virescens
BGC0000313.1 |  | 0.25 | NRP | beauvericin | Beauveria bassiana
BGC0001825.1 |  | 0.24 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001686.1 |  | 0.64 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000410.1 |  | 0.62 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000457.1 |  | 0.62 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000342.1 |  | 0.59 | NRP | enniatin | Fusarium equiseti
BGC0001873.1 |  | 0.59 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0000308.1 |  | 0.59 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000321.1 |  | 0.58 | NRP | chaetocin | Collariella virescens
BGC0000313.1 |  | 0.58 | NRP | beauvericin | Beauveria bassiana
BGC0001825.1 |  | 0.58 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 82006 - 129467:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asn - bht)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_111: asn - bht
  Search NORINE for peptide: strict or relaxed
  AMP-binding (475..867): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1502..1886): bht
  NRPSPredictor2: bht
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DASvIAdVCK
    Nearest Stachelhaus code:
      bht
    Stachelhaus code match:
      80% (moderate)

c00002_NZ_JHYD.. - Region 2 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 320,657 - 342,087 nt. (total: 21,431 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.16 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000703.1 |  | 0.16 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000486.1 |  | 0.15 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000601.1 |  | 0.14 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001928.1 |  | 0.14 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001765.1 |  | 0.14 | Saccharide | salecan | Agrobacterium tumefaciens
BGC0000586.1 |  | 0.13 | RiPP | microcin E492 | Klebsiella pneumoniae RYC492
BGC0001120.1 |  | 0.13 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000294.1 |  | 0.13 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000588.1 |  | 0.13 | RiPP | microcin L | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000600.1 |  | 0.47 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000703.1 |  | 0.46 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000601.1 |  | 0.44 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001928.1 |  | 0.43 | Other | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001765.1 |  | 0.43 | Saccharide | salecan | Agrobacterium tumefaciens
BGC0000586.1 |  | 0.42 | RiPP | microcin E492 | Klebsiella pneumoniae RYC492
BGC0001120.1 |  | 0.42 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000294.1 |  | 0.42 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000588.1 |  | 0.42 | RiPP | microcin L | Escherichia coli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00003_NZ_JHYD.. - Region 1 - ladderane
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 31,878 - 75,918 nt. (total: 44,041 nt) Show pHMM detection rules used
ladderane: ladderane

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ladderane | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001723.1 |  | 0.24 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0001177.1 |  | 0.23 | Polyketide | mensacaricin | Streptomyces bottropensis
BGC0001343.1 |  | 0.23 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000261.1 |  | 0.23 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0000234.1 |  | 0.23 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000236.1 |  | 0.23 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0000837.1 |  | 0.22 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0002008.1 |  | 0.22 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001197.1 |  | 0.22 | Polyketide | frankiamicin | Frankia sp. EAN1pec

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001723.1 |  | 0.58 | Polyketide | oviedomycin | Streptomyces antibioticus
BGC0000231.1 |  | 0.57 | Polyketide | griseusin | Streptomyces griseus
BGC0001177.1 |  | 0.56 | Polyketide | mensacaricin | Streptomyces bottropensis
BGC0001343.1 |  | 0.56 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000261.1 |  | 0.56 | Polyketide | R1128 | Streptomyces sp. R1128
BGC0000234.1 |  | 0.56 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000236.1 |  | 0.56 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0000837.1 |  | 0.55 | Other | APE Vf | Aliivibrio fischeri ES114
BGC0002008.1 |  | 0.55 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0001197.1 |  | 0.55 | Polyketide | frankiamicin | Frankia sp. EAN1pec

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00003_NZ_JHYD.. - Region 2 - NRPS,NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 203,951 - 260,810 nt. (total: 56,860 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001160.1 |  |  |  | 0.85 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001163.1 |  |  |  | 0.76 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001162.1 |  |  |  | 0.75 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0001161.1 |  |  |  | 0.75 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001831.1 |  |  |  | 0.66 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001023.1 |  |  |  | 0.63 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001758.1 |  |  |  | 0.62 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  |  |  | 0.62 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001275.1 |  |  |  | 0.62 | Polyketide | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001135.1 |  |  |  | 0.62 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001160.1 |  | 0.62 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001163.1 |  | 0.59 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001162.1 |  | 0.58 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0001161.1 |  | 0.58 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001831.1 |  | 0.57 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000343.1 |  | 0.57 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001292.1 |  | 0.56 | Other | A33853 | Streptomyces sp. NRRL 12068
BGC0000935.1 |  | 0.54 | Other (Aminocoumarin), Polyketide | esmeraldin | Streptomyces antibioticus
BGC0001023.1 |  | 0.54 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001897.1 |  | 0.54 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 203950 - 260810:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 203950 - 244709:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 207716 - 251202:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 213553 - 260810:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg3_207: pk
  CAL_domain (177..480): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 84.1
    NH2: 50.7
    Acetyl-CoA: 10.3
    shikimic_acid: 0.0
    AHBA: 0.0
ctg3_209: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (775..1199): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWHISLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      90% (moderate)
ctg3_211: mal
  PKS_AT (575..858): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 79.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 130.1
    inactive: 100.1
    Methoxymalonyl-CoA: 43.0
    Methylmalonyl-CoA: 33.4
    Propionyl-CoA: 13.1
    fatty_acid: 9.7
    Acetyl-CoA: 8.7
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

c00003_NZ_JHYD.. - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 267,826 - 316,824 nt. (total: 48,999 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.31 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000412.1 |  | 0.30 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000373.1 |  | 0.26 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000460.1 |  | 0.24 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0000343.1 |  | 0.22 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000351.1 |  | 0.22 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001591.1 |  | 0.22 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.22 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000347.1 |  | 0.21 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.64 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000412.1 |  | 0.63 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000373.1 |  | 0.60 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000460.1 |  | 0.57 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0000343.1 |  | 0.55 | NRP | enterobactin | Pseudomonas sp. J465
BGC0000351.1 |  | 0.55 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001591.1 |  | 0.54 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.54 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000347.1 |  | 0.54 | NRP | equibactin | Streptococcus equi subsp. equi
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 267825 - 316824:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg3_254: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (30..434): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPgQGiiCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      70% (weak)
ctg3_255: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (560..955): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg3_256: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (532..927): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNiSkIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      80% (moderate)

c00006_NZ_JHYD.. - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 176,519 - 197,958 nt. (total: 21,440 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001651.1 |  | 0.15 | Other | legionaminic acid | Tannerella forsythia 92A2
BGC0001887.1 |  | 0.14 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001810.1 |  | 0.14 | Polyketide | trehangelin | Polymorphospora rubra
BGC0001150.1 |  | 0.14 | Polyketide | pamamycin-607 | Streptomyces alboniger
BGC0001965.1 |  | 0.14 | Other | nybomycin | Streptomyces albus subsp. chlorinus
BGC0001850.1 |  | 0.14 | Other (Shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0000703.1 |  | 0.13 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000286.1 |  | 0.12 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001935.1 |  | 0.12 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.12 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001651.1 |  | 0.44 | Other | legionaminic acid | Tannerella forsythia 92A2
BGC0001887.1 |  | 0.44 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001810.1 |  | 0.44 | Polyketide | trehangelin | Polymorphospora rubra
BGC0001150.1 |  | 0.44 | Polyketide | pamamycin-607 | Streptomyces alboniger
BGC0001965.1 |  | 0.44 | Other | nybomycin | Streptomyces albus subsp. chlorinus
BGC0001850.1 |  | 0.43 | Other (Shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0000703.1 |  | 0.42 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000286.1 |  | 0.40 | Polyketide | viguiepinol | Streptomyces sp. KO-3988
BGC0001935.1 |  | 0.39 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.39 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00007_NZ_JHYD.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 29,251 - 49,968 nt. (total: 20,718 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.22 | RiPP | circularin A | Clostridium beijerinckii
BGC0001525.1 |  | 0.17 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0001526.1 |  | 0.17 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000571.1 |  | 0.16 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001407.1 |  | 0.16 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0001494.1 |  | 0.16 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0001391.1 |  | 0.16 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001229.1 |  | 0.16 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.55 | RiPP | circularin A | Clostridium beijerinckii
BGC0001525.1 |  | 0.48 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155
BGC0001526.1 |  | 0.48 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000571.1 |  | 0.47 | RiPP | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001407.1 |  | 0.47 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0001494.1 |  | 0.47 | RiPP | acinetodin | Acinetobacter gyllenbergii CIP 110306
BGC0001391.1 |  | 0.47 | RiPP | thusin | Bacillus thuringiensis serovar rongseni
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001229.1 |  | 0.47 | RiPP | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000504.1 |  | 0.47 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KK211292.1 - Region 1 - NRPS,T1PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 137,152 - 208,504 nt. (total: 71,353 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001050.1 |  |  |  | 1.20 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000979.1 |  |  |  | 0.99 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  |  | 0.99 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001023.1 |  |  |  | 0.99 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0000427.1 |  |  |  | 0.98 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001128.1 |  |  |  | 0.95 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  |  |  | 0.93 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000457.1 |  |  |  | 0.93 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000389.1 |  |  |  | 0.92 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001833.1 |  |  |  | 0.92 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001050.1 |  | 0.72 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000979.1 |  | 0.70 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.70 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000427.1 |  | 0.70 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.68 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001023.1 |  | 0.66 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0001128.1 |  | 0.66 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001561.1 |  | 0.66 | NRP | curacomycin | Streptomyces curacoi
BGC0000457.1 |  | 0.66 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0000460.1 |  | 0.66 | NRP | vulnibactin | Vibrio vulnificus CMCP6

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 137151 - 208504:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly) + (pk) + (ser) + (X) + (val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg9_121: pk - gly
  Search NORINE for peptide: strict or relaxed
  CAL_domain (164..476): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 116.8
    NH2: 18.6
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1137..1532): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGVIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
ctg9_122: pk
  PKS_AT (537..737): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: inactive
  Prediction, score:
    inactive: 30.3
    Malonyl-CoA: 19.2
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg9_123: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (539..942): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
ctg9_125: mal
  PKS_AT (6..294): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 79.2%
    inactive: 66.7%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 87.1
    inactive: 35.8
    Methoxymalonyl-CoA: 32.4
    Methylmalonyl-CoA: 23.7
    Propionyl-CoA: 11.7
    Ethylmalonyl-CoA: 10.5
    Acetyl-CoA: 9.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg9_126: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (540..939): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DvaNFCIiYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      70% (weak)
ctg9_128: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (6..410): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      asGfnySprK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      30% (weak)
ctg9_133: val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (277..671): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWlGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      90% (moderate)

NZ_KK211293.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 141,533 - 152,348 nt. (total: 10,816 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000131.1 |  | 0.17 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001521.1 |  | 0.14 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000131.1 |  | 0.48 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001521.1 |  | 0.43 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KK211295.1 - Region 1 - NRPS,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 59,208 nt. (total: 59,208 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000601.1 |  |  | 0.36 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001479.1 |  |  | 0.34 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001586.1 |  |  | 0.32 | Saccharide | EPS273 | Pseudomonas stutzeri
BGC0001135.1 |  |  | 0.32 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000294.1 |  |  | 0.32 | NRP | acinetobactin | Acinetobacter baumannii
BGC0001393.1 |  |  | 0.32 | NRP | lugdunin | Staphylococcus lugdunensis N920143
BGC0000504.1 |  |  | 0.31 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000901.1 |  |  | 0.31 | Other | ferrichrome | Aspergillus niger
BGC0001515.1 |  |  | 0.31 | NRP | aspercryptins | Aspergillus nidulans FGSC A4
BGC0001407.1 |  |  | 0.31 | RiPP | bicereucin | Bacillus cereus SJ1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001479.1 |  | 0.67 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001135.1 |  | 0.66 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000901.1 |  | 0.65 | Other | ferrichrome | Aspergillus niger
BGC0000389.1 |  | 0.64 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001249.1 |  | 0.64 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000426.1 |  | 0.64 | NRP | sevadicin | Paenibacillus larvae
BGC0000900.1 |  | 0.64 | Other | ferrichrome | Aspergillus oryzae
BGC0000348.1 |  | 0.64 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001833.1 |  | 0.64 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.64 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 59208:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - D-X - X) + (D-cys) + (X - gly) + (asn - X - asn)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 58049:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - D-X - X) + (D-cys) + (X - gly) + (asn - X - asn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg13_1: asn - X - asn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (274..670): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1314..1717): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFgLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (2359..2761): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
ctg13_2: X - gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..862): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmfqIGAVFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1509..1903): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLVWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
ctg13_4: pk - cys
  Search NORINE for peptide: strict or relaxed
  CAL_domain (167..477): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 151.2
    NH2: 11.0
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1133..1514): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg13_6: gly - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (271..666): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQmGMIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      90% (moderate)
  AMP-binding (1342..1743): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vAWeVtAddK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
  AMP-binding (2856..3257): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vAWeVtAddK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)

c00016_NZ_JHYD.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 58,417 - 79,877 nt. (total: 21,461 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.16 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001540.1 |  | 0.15 | Other | CC-1065 | Streptomyces zelensis
BGC0001887.1 |  | 0.15 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001607.1 |  | 0.15 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001637.1 |  | 0.09 | NRP | kleboxymycin | Klebsiella oxytoca
BGC0001228.1 |  | 0.09 | NRP | retimycin A | Salinispora arenicola CNT005
BGC0000450.1 |  | 0.08 | NRP | triostin A | Streptomyces triostinicus
BGC0000415.1 |  | 0.08 | NRP | quinomycin | Streptomyces griseovariabilis subsp. bandungensis
BGC0000247.1 |  | 0.08 | Polyketide, Saccharide | mithramycin | Streptomyces argillaceus
BGC0000448.1 |  | 0.08 | NRP | tomaymycin | Streptomyces achromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.46 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001540.1 |  | 0.45 | Other | CC-1065 | Streptomyces zelensis
BGC0001887.1 |  | 0.45 | RiPP | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001607.1 |  | 0.45 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001637.1 |  | 0.34 | NRP | kleboxymycin | Klebsiella oxytoca
BGC0001228.1 |  | 0.33 | NRP | retimycin A | Salinispora arenicola CNT005
BGC0000450.1 |  | 0.31 | NRP | triostin A | Streptomyces triostinicus
BGC0000415.1 |  | 0.31 | NRP | quinomycin | Streptomyces griseovariabilis subsp. bandungensis
BGC0000247.1 |  | 0.30 | Polyketide, Saccharide | mithramycin | Streptomyces argillaceus
BGC0000448.1 |  | 0.30 | NRP | tomaymycin | Streptomyces achromogenes

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00016_NZ_JHYD.. - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 85,211 - 105,777 nt. (total: 20,567 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000214.1 |  | 0.19 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0001654.1 |  | 0.19 | Saccharide | lipooligosaccharide | Bacteroides thetaiotaomicron VPI-5482
BGC0000797.1 |  | 0.17 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88
BGC0000759.1 |  | 0.17 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159
BGC0000768.1 |  | 0.17 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000803.1 |  | 0.16 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000724.1 |  | 0.16 | Saccharide | streptomycin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000690.1 |  | 0.16 | Saccharide | hydroxystreptomycin | Streptomyces glaucescens
BGC0000813.1 |  | 0.16 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000796.1 |  | 0.16 | Saccharide | S-layer glycan | Paenibacillus alvei

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000214.1 |  | 0.52 | Polyketide | cosmomycin B | Streptomyces olindensis
BGC0001654.1 |  | 0.51 | Saccharide | lipooligosaccharide | Bacteroides thetaiotaomicron VPI-5482
BGC0000797.1 |  | 0.48 | Saccharide | sphingan polysaccharide | Sphingomonas sp. S88
BGC0000759.1 |  | 0.48 | Saccharide | diutan polysaccharide | Sphingomonas sp. ATCC 53159
BGC0000768.1 |  | 0.47 | Saccharide | gellan polysaccharide | Sphingomonas elodea ATCC 31461
BGC0000803.1 |  | 0.47 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000724.1 |  | 0.47 | Saccharide | streptomycin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000690.1 |  | 0.47 | Saccharide | hydroxystreptomycin | Streptomyces glaucescens
BGC0000813.1 |  | 0.47 | Alkaloid | K-252a | Nonomuraea longicatena
BGC0000796.1 |  | 0.46 | Saccharide | S-layer glycan | Paenibacillus alvei

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00021_NZ_JHYD.. - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,590 - 32,599 nt. (total: 28,010 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000880.1 |  | 0.21 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0001929.1 |  | 0.21 | RiPP | WGK | Streptococcus ferus
BGC0000796.1 |  | 0.19 | Saccharide | S-layer glycan | Paenibacillus alvei
BGC0000575.1 |  | 0.19 | RiPP | lariatin | Rhodococcus jostii
BGC0001526.1 |  | 0.18 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000601.1 |  | 0.18 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001645.1 |  | 0.17 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0000792.1 |  | 0.17 | Saccharide | polysaccharide | Enterococcus faecalis OG1RF
BGC0001356.1 |  | 0.17 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001525.1 |  | 0.17 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000880.1 |  | 0.53 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882
BGC0001929.1 |  | 0.53 | RiPP | WGK | Streptococcus ferus
BGC0000796.1 |  | 0.52 | Saccharide | S-layer glycan | Paenibacillus alvei
BGC0000575.1 |  | 0.51 | RiPP | lariatin | Rhodococcus jostii
BGC0001526.1 |  | 0.49 | Other | bartolosides E, bartolosides F, bartolosides G, bartolosides H, bartolosides I, bartolosides J, bartolosides K | Synechocystis salina LEGE 06099
BGC0000601.1 |  | 0.49 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0001645.1 |  | 0.49 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0000792.1 |  | 0.49 | Saccharide | polysaccharide | Enterococcus faecalis OG1RF
BGC0001356.1 |  | 0.49 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001525.1 |  | 0.49 | Other | bartoloside 2, bartoloside 3, bartoloside 4 | Synechocystis salina LEGE 06155

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00022_NZ_JHYD.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 67,934 - 88,557 nt. (total: 20,624 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000863.1 |  | 0.08 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0001575.1 |  | 0.08 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0000861.1 |  | 0.07 | Other | eicosapentaenoic acid | Shewanella sp. BR-2
BGC0000452.1 |  | 0.06 | NRP | tyrocidine | Brevibacillus brevis NBRC 100599
BGC0000403.1 |  | 0.06 | NRP | pelgipeptin | Paenibacillus elgii
BGC0000984.1 |  | 0.06 | NRP, Polyketide | delftibactin A, delftibactin B | Delftia acidovorans SPH-1
BGC0000320.1 |  | 0.06 | NRP | cereulide | Bacillus cereus
BGC0000862.1 |  | 0.06 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0001625.1 |  | 0.05 | Polyketide | isofuranonaphthoquinone | Streptomyces sp. CB01883
BGC0001386.1 |  | 0.05 | Polyketide | JBIR-76, JBIR-77 | Streptomyces sp. RI-77

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000863.1 |  | 0.30 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0001575.1 |  | 0.30 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0000861.1 |  | 0.29 | Other | eicosapentaenoic acid | Shewanella sp. BR-2
BGC0000452.1 |  | 0.26 | NRP | tyrocidine | Brevibacillus brevis NBRC 100599
BGC0000403.1 |  | 0.25 | NRP | pelgipeptin | Paenibacillus elgii
BGC0000984.1 |  | 0.25 | NRP, Polyketide | delftibactin A, delftibactin B | Delftia acidovorans SPH-1
BGC0000320.1 |  | 0.25 | NRP | cereulide | Bacillus cereus
BGC0000862.1 |  | 0.25 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0001625.1 |  | 0.24 | Polyketide | isofuranonaphthoquinone | Streptomyces sp. CB01883
BGC0001386.1 |  | 0.24 | Polyketide | JBIR-76, JBIR-77 | Streptomyces sp. RI-77

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00023_NZ_JHYD.. - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 18,940 - 39,533 nt. (total: 20,594 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.16 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001743.1 |  | 0.16 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0000620.1 |  | 0.16 | RiPP | lacticin Q | Lactococcus lactis
BGC0001222.1 |  | 0.15 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.15 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000522.1 |  | 0.15 | RiPP | lacticin Z | Lactococcus lactis
BGC0000504.1 |  | 0.15 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000600.1 |  | 0.14 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000243.1 |  | 0.14 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0001607.1 |  | 0.14 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.1 |  | 0.47 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0001743.1 |  | 0.46 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0000620.1 |  | 0.46 | RiPP | lacticin Q | Lactococcus lactis
BGC0001222.1 |  | 0.46 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.46 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000522.1 |  | 0.46 | RiPP | lacticin Z | Lactococcus lactis
BGC0000504.1 |  | 0.46 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000600.1 |  | 0.44 | RiPP | thurincin H | Bacillus thuringiensis
BGC0000243.1 |  | 0.44 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0001607.1 |  | 0.44 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00026_NZ_JHYD.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 41,446 - 85,792 nt. (total: 44,347 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.31 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001686.1 |  | 0.24 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000308.1 |  | 0.23 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1 |  | 0.22 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.22 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001131.1 |  | 0.22 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001615.1 |  | 0.21 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001844.1 |  | 0.21 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.21 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.21 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001686.1 |  | 0.58 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000308.1 |  | 0.56 | NRP | aureusimine | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001479.1 |  | 0.55 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.55 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001131.1 |  | 0.54 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001615.1 |  | 0.54 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001844.1 |  | 0.54 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.53 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.53 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 41445 - 85792:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg26_56: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (874..1272): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DacYFGGiVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)

c00030_NZ_JHYD.. - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 20,690 nt. (total: 20,690 nt) Show pHMM detection rules used
Region on contig edge.
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000904.1 |  | 0.23 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001323.1 |  | 0.18 | Terpene | monoterpenes-diterpenes | Solanum pennellii
BGC0001664.1 |  | 0.18 | Terpene | merosterol | Scytonema sp. PCC 10023
BGC0001636.1 |  | 0.15 | NRP | KK-1 | Curvularia clavata
BGC0001774.1 |  | 0.15 | Other | spicamycin | Streptomyces fimbriatus
BGC0000673.1 |  | 0.15 | Terpene | pimara-8(14),15-diene | Aspergillus nidulans FGSC A4
BGC0000196.1 |  | 0.15 | Polyketide | AQ-256, AQ-270a, AQ-284a | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001411.1 |  | 0.14 | Saccharide | polysaccharide B | Bacteroides fragilis
BGC0001321.1 |  | 0.14 | Terpene | monoterpenes-diterpenes | Solanum habrochaites
BGC0000913.1 |  | 0.14 | Other | MK-8 | Enterobacter cloacae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000904.1 |  | 0.56 | Other | FR-900098 | Streptomyces rubellomurinus
BGC0001323.1 |  | 0.50 | Terpene | monoterpenes-diterpenes | Solanum pennellii
BGC0001664.1 |  | 0.50 | Terpene | merosterol | Scytonema sp. PCC 10023
BGC0001636.1 |  | 0.45 | NRP | KK-1 | Curvularia clavata
BGC0001774.1 |  | 0.44 | Other | spicamycin | Streptomyces fimbriatus
BGC0000673.1 |  | 0.44 | Terpene | pimara-8(14),15-diene | Aspergillus nidulans FGSC A4
BGC0000196.1 |  | 0.44 | Polyketide | AQ-256, AQ-270a, AQ-284a | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001411.1 |  | 0.43 | Saccharide | polysaccharide B | Bacteroides fragilis
BGC0001321.1 |  | 0.43 | Terpene | monoterpenes-diterpenes | Solanum habrochaites
BGC0000913.1 |  | 0.43 | Other | MK-8 | Enterobacter cloacae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00033_NZ_JHYD.. - Region 1 - NRPS,transAT-PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 14,074 - 55,758 nt. (total: 41,685 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS-like | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001135.1 |  |  | 0.61 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  |  | 0.60 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  |  | 0.59 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001767.1 |  |  | 0.58 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001050.1 |  |  | 0.58 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001833.1 |  |  | 0.57 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000979.1 |  |  | 0.56 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  | 0.56 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  |  | 0.56 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000389.1 |  |  | 0.56 | NRP | massetolide A | Pseudomonas fluorescens SS101

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.1 |  | 0.64 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.63 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.63 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001767.1 |  | 0.63 | NRP | salinichelins | Salinispora pacifica CNY331
BGC0001050.1 |  | 0.62 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0001833.1 |  | 0.62 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000979.1 |  | 0.61 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.61 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000389.1 |  | 0.61 | NRP | massetolide A | Pseudomonas fluorescens SS101

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 14073 - 55758:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asn - X - tyr - ser) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 19635 - 55758:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (asn - X - tyr - ser) + (ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg33_29: asn - X - tyr - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (275..670): asn
  NRPSPredictor2: asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      asp, asn
    Single AA prediction:
      asn
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code:
      asn
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1309..1707): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      vAWeItAddK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
  AMP-binding (2348..2743): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3389..3799): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

c00051_NZ_JHYD.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,139 nt. (total: 16,139 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001050.1 |  | 0.38 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000427.1 |  | 0.36 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000389.1 |  | 0.35 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.35 | NRP | sevadicin | Paenibacillus larvae
BGC0000901.1 |  | 0.33 | Other | ferrichrome | Aspergillus niger
BGC0001261.1 |  | 0.33 | NRP | AM-toxin | Alternaria alternata
BGC0000900.1 |  | 0.31 | Other | ferrichrome | Aspergillus oryzae
BGC0001132.1 |  | 0.29 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001479.1 |  | 0.29 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001135.1 |  | 0.28 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001050.1 |  | 0.70 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000427.1 |  | 0.69 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000389.1 |  | 0.68 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000426.1 |  | 0.68 | NRP | sevadicin | Paenibacillus larvae
BGC0000901.1 |  | 0.67 | Other | ferrichrome | Aspergillus niger
BGC0001261.1 |  | 0.66 | NRP | AM-toxin | Alternaria alternata
BGC0000900.1 |  | 0.64 | Other | ferrichrome | Aspergillus oryzae
BGC0001132.1 |  | 0.63 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001479.1 |  | 0.62 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001135.1 |  | 0.62 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 16139:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser - ser) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg51_1: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (13..419): X
  NRPSPredictor2: pro, pip
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DArHLaLmvK
    Nearest Stachelhaus code:
      hpg
    Stachelhaus code match:
      60% (weak)
ctg51_4: ser - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (472..875): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1515..1919): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVeK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      90% (moderate)

c00060_NZ_JHYD.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 4,656 nt. (total: 4,656 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.23 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001479.1 |  | 0.23 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001758.1 |  | 0.22 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.22 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001641.1 |  | 0.22 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.21 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001873.1 |  | 0.21 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0001825.1 |  | 0.21 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.1 |  | 0.21 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001615.1 |  | 0.21 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.56 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001479.1 |  | 0.56 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001758.1 |  | 0.55 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.55 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001641.1 |  | 0.54 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.54 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001873.1 |  | 0.54 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0001825.1 |  | 0.54 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.1 |  | 0.54 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001615.1 |  | 0.54 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00067_NZ_JHYD.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 2,215 nt. (total: 2,215 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.1 |  | 0.22 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1 |  | 0.22 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.1 |  | 0.22 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001479.1 |  | 0.22 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001844.1 |  | 0.22 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.22 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.22 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.22 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.22 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0000307.1 |  | 0.21 | NRP | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.1 |  | 0.55 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1 |  | 0.55 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.1 |  | 0.55 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001479.1 |  | 0.55 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001844.1 |  | 0.55 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001833.1 |  | 0.55 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.55 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.1 |  | 0.55 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.55 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0000307.1 |  | 0.53 | NRP | AbT1 | Aureobasidium pullulans

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
c00068_NZ_JHYD.. - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 1,880 nt. (total: 1,880 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000900.1 |  | 0.32 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.31 | NRP | dimethylcoprogen | Alternaria alternata
BGC0001479.1 |  | 0.29 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.29 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001132.1 |  | 0.26 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000375.1 |  | 0.25 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001135.1 |  | 0.25 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.25 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000348.1 |  | 0.24 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001261.1 |  | 0.24 | NRP | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.65 | NRP | dimethylcoprogen | Alternaria alternata
BGC0001479.1 |  | 0.63 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000427.1 |  | 0.63 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001132.1 |  | 0.59 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000375.1 |  | 0.59 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001135.1 |  | 0.59 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.58 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000348.1 |  | 0.57 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001261.1 |  | 0.57 | NRP | AM-toxin | Alternaria alternata

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 1880:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg68_1: leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (0..378): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DpALIGdVcK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      70% (weak)