GCF_020892115.1_ASM2089211v1_genomic - 3 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_AP024846.1

Region	Type	From	To
Region 1	RRE-containing	702,211	720,376
Region 2	NRPS	1,866,786	1,914,141
Region 3	ranthipeptide	2,031,031	2,052,688

NZ_AP024846.1 - Region 1 - RRE-containing

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Location: 702,211 - 720,376 nt. (total: 18,166 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.1	0.16	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001551.1	0.16	RiPP	citrulassin E	Streptomyces glaucescens
BGC0000504.1	0.15	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000916.1	0.15	Other	molybdenum cofactor	Staphylococcus carnosus
BGC0000500.1	0.15	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000558.1	0.15	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000548.1	0.15	RiPP	salivaricin A	Streptococcus salivarius
BGC0000294.1	0.15	NRP	acinetobactin	Acinetobacter baumannii
BGC0000801.1	0.14	Saccharide	galactoglucan	Sinorhizobium meliloti
BGC0002009.1	0.14	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.1	0.47	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001551.1	0.46	RiPP	citrulassin E	Streptomyces glaucescens
BGC0000504.1	0.46	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000916.1	0.45	Other	molybdenum cofactor	Staphylococcus carnosus
BGC0000500.1	0.45	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000558.1	0.45	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000548.1	0.45	RiPP	salivaricin A	Streptococcus salivarius
BGC0000294.1	0.44	NRP	acinetobactin	Acinetobacter baumannii
BGC0000801.1	0.44	Saccharide	galactoglucan	Sinorhizobium meliloti
BGC0002009.1	0.44	Polyketide	kanglemycin A, kanglemycin V1, kanglemycin V2	Amycolatopsis vancoresmycina

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NZ_AP024846.1 - Region 2 - NRPS

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Location: 1,866,786 - 1,914,141 nt. (total: 47,356 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457.1	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417.1	0.25	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000321.1	0.24	NRP	chaetocin	Collariella virescens
BGC0001185.1	0.24	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000430.1	0.23	NRP, Polyketide	spumigin E	Nodularia spumigena CCY9414
BGC0001132.1	0.23	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001585.1	0.23	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0000349.1	0.23	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001825.1	0.23	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000401.1	0.23	NRP	paenibactin	Paenibacillus elgii B69

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457.1	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417.1	0.58	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000321.1	0.58	NRP	chaetocin	Collariella virescens
BGC0001185.1	0.57	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000430.1	0.56	NRP, Polyketide	spumigin E	Nodularia spumigena CCY9414
BGC0001132.1	0.56	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001585.1	0.56	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0000349.1	0.56	NRP	erythrochelin	Saccharopolyspora erythraea NRRL 2338
BGC0001825.1	0.56	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000401.1	0.56	NRP	paenibactin	Paenibacillus elgii B69

Similar known gene clusters

No matches found.

Module view

Legend

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 1866785 - 1914141:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (leu - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_1875

Search NORINE for peptide: strict or relaxed

AMP-binding (34..444): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: tycmpGGPLK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 50% (weak)

ctg1_1878

Search NORINE for peptide: strict or relaxed

AMP-binding (474..859): leu

NRPSPredictor2: leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: leu

Stachelhaus prediction details:

Stachelhaus sequence:: DAlAIgqVaK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

AMP-binding (1496..1882): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DvTqIliVhK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 50% (weak)

NZ_AP024846.1 - Region 3 - ranthipeptide

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Location: 2,031,031 - 2,052,688 nt. (total: 21,658 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001387.1	0.16	Other	nucleocidin	Streptomyces calvus
BGC0001607.1	0.14	Other	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0001540.1	0.14	Other	CC-1065	Streptomyces zelensis
BGC0001995.1	0.11	Terpene	heptelidic acid	Aspergillus oryzae RIB40
BGC0000678.1	0.10	Terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001591.1	0.09	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.09	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001155.1	0.08	RiPP	GE2270	Planobispora rosea
BGC0000604.1	0.08	RiPP	GE2270A	Nonomuraea sp. WU8817
BGC0000653.1	0.06	Terpene	pentalenolactone	Streptomyces arenae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001387.1	0.47	Other	nucleocidin	Streptomyces calvus
BGC0001607.1	0.44	Other	gilvusmycin	Streptomyces sp. NRRL B-1347
BGC0001540.1	0.44	Other	CC-1065	Streptomyces zelensis
BGC0001995.1	0.38	Terpene	heptelidic acid	Aspergillus oryzae RIB40
BGC0000678.1	0.36	Terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001591.1	0.32	Other	fatty acid enol ester	uncultured bacterium CSLC2
BGC0001688.1	0.32	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001155.1	0.32	RiPP	GE2270	Planobispora rosea
BGC0000604.1	0.31	RiPP	GE2270A	Nonomuraea sp. WU8817
BGC0000653.1	0.27	Terpene	pentalenolactone	Streptomyces arenae

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names