LOCUS       NZ_CP045237.1          10816 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP045237.1 Burkholderia cepacia strain BC16 chromosome 3,
            complete sequence.
ACCESSION   NZ_CP045237
VERSION     NZ_CP045237.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:04:28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 333262
            Orig. end    :: 344078
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[338262:339078](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5816
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(662..850)
                     /locus_tag="ctg3_297"
                     /transl_table=11
                     /translation="MTGLRVTAARRTAAIREPMLLHVRPVNGPVPGRAVAFESVHHAGR
                     IWRFLAKLSLTFVEMTQ"
     CDS             complement(870..1124)
                     /locus_tag="ctg3_298"
                     /transl_table=11
                     /translation="MRIDQSYRRFDIAATLTPLPGSGNRAIATVDVTTDDPARVADLGT
                     GQFLQIRKWVESNDVAWLTVVFDECKVAIDHYADNVDDA"
     CDS             complement(1159..1614)
                     /locus_tag="ctg3_299"
                     /transl_table=11
                     /translation="MTRQLIVAVFGSVDTARRAASDFGALSDKHEGFHIENGVVVEKDA
                     TGKLAVLDAESRPFKGGVIGAIAGGLLGLLAGPLGVVTGMAAGAGAGILAEAAGNALLD
                     GTFVETIAARLVPGSVAVILEAKEDTPFSVDNVVTGFGGKVFRQTLD"
     PFAM_domain     complement(1165..1425)
                     /aSDomain="DUF1269"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06897.14"
                     /description="Protein of unknown function (DUF1269)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_299_0001"
                     /evalue="3.80E-11"
                     /label="ctg3_299"
                     /locus_tag="ctg3_299"
                     /protein_end="150"
                     /protein_start="63"
                     /score="43.2"
                     /tool="antismash"
                     /translation="IGAIAGGLLGLLAGPLGVVTGMAAGAGAGILAEAAGNALLDGTFV
                     ETIAARLVPGSVAVILEAKEDTPFSVDNVVTGFGGKVFRQTL"
     CDS             complement(1718..2167)
                     /locus_tag="ctg3_300"
                     /transl_table=11
                     /translation="LNTTTVPRSPAERIRRRFGHFLHAAELAGLIVIGLATAFAMAQEA
                     WKVVLAGEVSLTDLLLMFLYLEVLAMDVRYLRLGRLPVRFPLFIAMTSLARDLILRGAT
                     DSPERMLMTTFGIVLLAVGVLILSFGQHRFPADVDDVEDDVHARR"
     PFAM_domain     complement(1775..2089)
                     /aSDomain="PsiE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06146.14"
                     /description="Phosphate-starvation-inducible E family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_300_0002"
                     /evalue="1.50E-15"
                     /label="ctg3_300"
                     /locus_tag="ctg3_300"
                     /protein_end="131"
                     /protein_start="26"
                     /score="57.5"
                     /tool="antismash"
                     /translation="LAGLIVIGLATAFAMAQEAWKVVLAGEVSLTDLLLMFLYLEVLAM
                     DVRYLRLGRLPVRFPLFIAMTSLARDLILRGATDSPERMLMTTFGIVLLAVGVLILSFG
                     Q"
     CDS             complement(2164..2565)
                     /locus_tag="ctg3_301"
                     /transl_table=11
                     /translation="MNLLEAMRVYVAVVERGGLSGAASELRLDEAQVSERIDCLERYLG
                     CRLLLCCEHDDVACSDAGVAFHVCCRRTLSAVEQAIGAAGAHAPAVPDAPDAPDAADAP
                     DGGAVHAAARDAAFPPPGAVQVSSTRLSP"
     PFAM_domain     complement(2416..2556)
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_301_0003"
                     /evalue="5.30E-09"
                     /label="ctg3_301"
                     /locus_tag="ctg3_301"
                     /protein_end="50"
                     /protein_start="3"
                     /score="36.0"
                     /tool="antismash"
                     /translation="LEAMRVYVAVVERGGLSGAASELRLDEAQVSERIDCLERYLGCRL
                     LL"
     CDS             2934..3995
                     /locus_tag="ctg3_302"
                     /transl_table=11
                     /translation="MTDRQPAMQTPPPLSQAVHSPITRSAIFLVATINPGAEHADTIRS
                     WCGDIAALVRSVGKRVPGGNLTCVCGFGSDAWDALFGAPRPAALHPFREFGAGQRVAVA
                     TPGDILLHIRAEAMDLCFELATQLLGALGDAVTVVDEVHGFRNFDQRAMIGFVDGTENP
                     EGREAVDFTVIGDEDAEFAGGSYVIVQKYLHDMAGWNALAVETQERIIGRTKLSDIELA
                     PDVKPSCSHSSLTTLDENGQEVKILRDNMPFGRPGAGEFGTYFIGYARSPAPIEQMLEN
                     MFVGRPPGNYDRLLDYSRAVTGSLFFVPSADLLEALADRAAPAADAAQPEASPSAPHRD
                     GSLKIGSLKGIPS"
     PFAM_domain     2979..3869
                     /aSDomain="Dyp_perox"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04261.14"
                     /description="Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_302_0004"
                     /evalue="2.10E-91"
                     /label="ctg3_302"
                     /locus_tag="ctg3_302"
                     /protein_end="312"
                     /protein_start="15"
                     /score="306.5"
                     /tool="antismash"
                     /translation="QAVHSPITRSAIFLVATINPGAEHADTIRSWCGDIAALVRSVGKR
                     VPGGNLTCVCGFGSDAWDALFGAPRPAALHPFREFGAGQRVAVATPGDILLHIRAEAMD
                     LCFELATQLLGALGDAVTVVDEVHGFRNFDQRAMIGFVDGTENPEGREAVDFTVIGDED
                     AEFAGGSYVIVQKYLHDMAGWNALAVETQERIIGRTKLSDIELAPDVKPSCSHSSLTTL
                     DENGQEVKILRDNMPFGRPGAGEFGTYFIGYARSPAPIEQMLENMFVGRPPGNYDRLLD
                     YSRAVTGSLFFVPSAD"
     aSDomain        2982..3869
                     /aSDomain="TIGR01413"
                     /aSTool="tigrfam"
                     /description="Dyp_perox_fam: Dyp-type peroxidase family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_302_0001"
                     /evalue="3.40E-86"
                     /identifier="TIGR01413"
                     /label="ctg3_302"
                     /locus_tag="ctg3_302"
                     /protein_end="312"
                     /protein_start="16"
                     /score="287.4"
                     /tool="antismash"
                     /translation="AVHSPITRSAIFLVATINPGAEHADTIRSWCGDIAALVRSVGKRV
                     PGGNLTCVCGFGSDAWDALFGAPRPAALHPFREFGAGQRVAVATPGDILLHIRAEAMDL
                     CFELATQLLGALGDAVTVVDEVHGFRNFDQRAMIGFVDGTENPEGREAVDFTVIGDEDA
                     EFAGGSYVIVQKYLHDMAGWNALAVETQERIIGRTKLSDIELAPDVKPSCSHSSLTTLD
                     ENGQEVKILRDNMPFGRPGAGEFGTYFIGYARSPAPIEQMLENMFVGRPPGNYDRLLDY
                     SRAVTGSLFFVPSAD"
     CDS             complement(4172..4561)
                     /locus_tag="ctg3_303"
                     /transl_table=11
                     /translation="MALQLVSPEDKYMLKTGVINHEDVIGHLRQVLNAFAAKPEYSKFY
                     IGITSDLYTRLAKHRATKPDFKLMAPIYLEAHNLVGNAFDRLERKAIETFRTGITHPQS
                     GERLLACSNGPGGALPKNWLYILVG"
     PFAM_domain     5001..5753
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_304_0005"
                     /evalue="1.90E-93"
                     /label="ctg3_304"
                     /locus_tag="ctg3_304"
                     /protein_end="251"
                     /protein_start="0"
                     /score="312.6"
                     /tool="antismash"
                     /translation="MNNLHRELAPISSSAWEQIEEEVARTFKRSVAGRRVVDVDGPEGP
                     ELSAVGTGHLVTVDAPREHVNARLREVRTIVELTVPFELSRDAIDSVERGARDADWQPA
                     KDAAQRLAFAEDNAIFDGYRAAGIVGIREGTSNRKLTLPADVSAYPDAISDALEALRLA
                     GVDGPYSVVLGSDAYTALSEARDQGYPVLGHIKRIVSGEIIWAPAISGGCVLSTRGGDY
                     ELHLGEDVSIGYTSHTDKVVRLYLRETFT"
     CDS             5001..5816
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_304"
                     /sec_met_domain="Linocin_M18 (E-value: 9.9e-94, bitscore:
                     309.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRELAPISSSAWEQIEEEVARTFKRSVAGRRVVDVDGPEGP
                     ELSAVGTGHLVTVDAPREHVNARLREVRTIVELTVPFELSRDAIDSVERGARDADWQPA
                     KDAAQRLAFAEDNAIFDGYRAAGIVGIREGTSNRKLTLPADVSAYPDAISDALEALRLA
                     GVDGPYSVVLGSDAYTALSEARDQGYPVLGHIKRIVSGEIIWAPAISGGCVLSTRGGDY
                     ELHLGEDVSIGYTSHTDKVVRLYLRETFTFLMLTSEASVAVAPQGNPTA"
     CDS             5919..6188
                     /locus_tag="ctg3_305"
                     /transl_table=11
                     /translation="MSESNEALQALQASVDQLKQAVDANASRQAGDTAVLFTVLSLVLA
                     ELPPDTRNLIEDSFSVWANGLPDAALSTDVKQIARQRLAMTLPD"
     misc_feature    5940..5942
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             6817..9651
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     1000.5; E-value: 9.9e-303)"
                     /gene_kind="other"
                     /locus_tag="ctg3_306"
                     /transl_table=11
                     /translation="MPALCDICHARPAVARATVMQDGERKTISICDYHFRQLMRHQSML
                     NPFDSLLGGGGSSSLFGGLGDESPLAAEVPRESVDPTDAFSEQTLELLQRAAEKAHELR
                     RSELDSEHLLYALADTDVCAALLKELKLSPQDIRSYIDEHAHTGTADPDAPLDKLSISP
                     RVKKAVQYAFQASRDLGHSYIGPEHLLIGLASVPDSVAGTLLKKYGVTPEALRQKVVKV
                     VGKGAEDGRVDAPTGTPNLDKFGRDLTAIARQGKLDPVLGRAQEIESTIEVLARRKKNN
                     PVLIGEPGVGKTAIVEGLAQRIVNGDVPEVLRDKRLVEVNINSMVAGAKYRGEFEERAK
                     QLIDEVTAKQDELILFIDELHTIVGAGQGGGEGGLDIANVLKPALARGELSLIGATTLN
                     EYQKYIEKDAALERRFQPVFVPEPSVEQTIVILRGLRDSLEAHHQVTFADDAFVAAAEF
                     ADRYITSRFLPDKAIDLIDQAAARVRIGATSRPVDIQEGEAQIAQLKREQDYATSRKRF
                     DEAKQFEEQINAKQKSVDEKMEAWQRKTGSETLEVTVESVAEVVSRLTGIPVSELTQEE
                     RQKLLKMEEQLRERVVGQSDAVVAVSDAVRLSRAGLGQTHRPIATFLFLGPTGVGKTEL
                     AKALAETVFGDEQAIIRIDMSEYMERHAVARLIGAPPGYVGYDEGGQLTERVRRRPYSV
                     ILLDEIEKAHPDVYNVLLQVFDDGRLTDGKGRVVDFSNTIIIATSNLGAAIIMDNLTQP
                     EAARKTDKAVREELMQVLKGHFRPEFLNRIDEVIVFHALSKENIRSIVQIQLDRVVRTA
                     AAQDITLVMGDSLVEHLTEAGYQPEFGARELKRQIRQTIETRLAKEILADRLKSGDKCE
                     VDYDKDSNEVKFNKLAAPEAKEAKETKEADGKAKPNGKAAKAADAKPDDTPADAPPPAA
                     KPGKKTSGAKKDAH"
     PFAM_domain     7102..7245
                     /aSDomain="Clp_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02861.22"
                     /description="Clp amino terminal domain, pathogenicity
                     island component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_306_0006"
                     /evalue="3.30E-06"
                     /label="ctg3_306"
                     /locus_tag="ctg3_306"
                     /protein_end="143"
                     /protein_start="95"
                     /score="27.2"
                     /tool="antismash"
                     /translation="AAEKAHELRRSELDSEHLLYALADTDVCAALLKELKLSPQDIRSY
                     IDE"
     PFAM_domain     7330..7488
                     /aSDomain="Clp_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02861.22"
                     /description="Clp amino terminal domain, pathogenicity
                     island component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_306_0007"
                     /evalue="9.80E-16"
                     /label="ctg3_306"
                     /locus_tag="ctg3_306"
                     /protein_end="224"
                     /protein_start="171"
                     /score="57.7"
                     /tool="antismash"
                     /translation="AFQASRDLGHSYIGPEHLLIGLASVPDSVAGTLLKKYGVTPEALR
                     QKVVKVVG"
     PFAM_domain     7663..8064
                     /aSDomain="AAA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00004.31"
                     /description="ATPase family associated with various
                     cellular activities (AAA)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_306_0008"
                     /evalue="5.10E-14"
                     /label="ctg3_306"
                     /locus_tag="ctg3_306"
                     /protein_end="416"
                     /protein_start="282"
                     /score="52.9"
                     /tool="antismash"
                     /translation="VLIGEPGVGKTAIVEGLAQRIVNGDVPEVLRDKRLVEVNINSMVA
                     GAKYRGEFEERAKQLIDEVTAKQDELILFIDELHTIVGAGQGGGEGGLDIANVLKPALA
                     RGELSLIGATTLNEYQKYIEKDAALERRFQ"
     PFAM_domain     8086..8391
                     /aSDomain="AAA_lid_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17871.3"
                     /description="AAA lid domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_306_0009"
                     /evalue="9.40E-31"
                     /label="ctg3_306"
                     /locus_tag="ctg3_306"
                     /protein_end="525"
                     /protein_start="423"
                     /score="105.9"
                     /tool="antismash"
                     /translation="SVEQTIVILRGLRDSLEAHHQVTFADDAFVAAAEFADRYITSRFL
                     PDKAIDLIDQAAARVRIGATSRPVDIQEGEAQIAQLKREQDYATSRKRFDEAKQFEE"
     PFAM_domain     8665..9174
                     /aSDomain="AAA_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07724.16"
                     /description="AAA domain (Cdc48 subfamily)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_306_0010"
                     /evalue="1.00E-54"
                     /label="ctg3_306"
                     /locus_tag="ctg3_306"
                     /protein_end="786"
                     /protein_start="616"
                     /score="185.3"
                     /tool="antismash"
                     /translation="RPIATFLFLGPTGVGKTELAKALAETVFGDEQAIIRIDMSEYMER
                     HAVARLIGAPPGYVGYDEGGQLTERVRRRPYSVILLDEIEKAHPDVYNVLLQVFDDGRL
                     TDGKGRVVDFSNTIIIATSNLGAAIIMDNLTQPEAARKTDKAVREELMQVLKGHFRPEF
                     LNRIDEV"
     PFAM_domain     9190..9432
                     /aSDomain="ClpB_D2-small"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF10431.11"
                     /description="C-terminal, D2-small domain, of ClpB protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_306_0011"
                     /evalue="3.10E-21"
                     /label="ctg3_306"
                     /locus_tag="ctg3_306"
                     /protein_end="872"
                     /protein_start="791"
                     /score="75.2"
                     /tool="antismash"
                     /translation="LSKENIRSIVQIQLDRVVRTAAAQDITLVMGDSLVEHLTEAGYQP
                     EFGARELKRQIRQTIETRLAKEILADRLKSGDKCEV"
ORIGIN
        1 agcgccgtgc gatctgccgg atcagccgcg gatgcccggg cggcaatccg tccgtcacgc
       61 cccacagcga cttgtcgcgg ccggccgcat acgcatagcg gttcagcttc tcgaacggga
      121 acaggctcgg gtccgggtac ggcgagccga gcggcaccgc gtcgtcggta ccgatcgcgc
      181 gcagcgtcga cagcacgagc cggctcacgt cgaccgacga cgagatcgcg atcggcttcg
      241 acggccgcag ctcgcgcacc ggcgcatggc cgtcgtcgcg ccgcaggttc acgaaatagc
      301 cggactgcgg gcggctttcg agcagcccgc ggctttccag cagcagatac gcgtgcagca
      361 cggtcgtgat gctgatccgg tgctgctggc tcgcctgccg caccgacggc acacgatcgc
      421 cgtgtcgata tacgccttgc cggatgagtc tctctacgtc gtttgcaaat ttctcgtaga
      481 gcttcatccg cctcgccccg ccagcggtga accggcctgc ggtgcacggg cggcatggcc
      541 gcgccggtgc acgaagccgg atagccgtgc ccgggcgcgg gggtcccggt tcgaacctcg
      601 tccgttatcg aaattgaagg cggatagcaa cgcgaatctc atctagacaa ggttcggcat
      661 cctactgcgt catttcgacg aatgtaagtg acagtttggc gaggaaacgc caaatccgcc
      721 cggcgtggtg aacagattcg aacgcgacgg cacggcccgg cacggggcca ttcaccgggc
      781 gcacatgcag gagcatgggc tcgcgtattg ccgccgtccg gcgggcggcc gtcacgcgaa
      841 gcccggtcat gcgcgggcct cgcgtgtgat caagcgtcgt cgacgttgtc cgcgtagtgg
      901 tcgatcgcga ccttgcactc gtcgaacacc accgtcagcc acgcgacgtc gttcgactcg
      961 acccacttgc ggatctgcag gaattgcccg gtgccgagat cggcgacgcg ggccggatcg
     1021 tcggtcgtca cgtcgacggt cgcgatcgcg cgattgccgc tgcccggcag cggcgtcaac
     1081 gtcgccgcga tgtcgaagcg ccggtacgat tgatcgatgc gcatgcggtt ctcccgaagc
     1141 aggtcgaatg gaagcgtgtc aatcgagcgt ctggcggaac accttgccgc cgaatccggt
     1201 cacgacgttg tcgaccgaga acggcgtgtc ctccttcgct tcgaggatga ccgcgacgct
     1261 gccgggcacg agccgcgccg caatcgtctc gacgaacgtg ccgtcgagca gcgcgttgcc
     1321 ggccgcttcc gcgagaatgc cggcccccgc gccggccgcc atgccggtga ccacgccgag
     1381 cggcccggcg agcagcccga gcagcccgcc tgcgatcgcg ccgatcacgc cgcccttgaa
     1441 cggtcgcgat tcggcatcga gcaccgcgag cttgccggtc gcgtccttct cgacgacgac
     1501 gccgttctcg atgtggaatc cctcatgctt gtccgacagc gccccgaaat cgctcgcggc
     1561 ccgacgggcc gtgtcgacgc tgccgaacac ggcgacgatc agttgcctgg tcattcgata
     1621 cctcgctcgg ttggttggtc agtttgatca gtttggccgc attggccgct ctagccggtt
     1681 acaaccgccg caccgcatgc ggcacgccgc ccgcttccta cctgcgcgca tgcacatcgt
     1741 cctcgacatc gtcgacgtcc gccggaaagc gatgctggcc gaaactcagg atcagcacgc
     1801 ccaccgcgag cagcacgatt ccgaacgtcg tcatcagcat ccgctcgggg ctgtcggtcg
     1861 ccccgcgcag gatcaggtcg cgcgcgagcg acgtcatcgc aatgaacagc ggaaaccgca
     1921 cgggcagccg gccgagccgc aggtagcgca cgtccatcgc gagcacttcc aggtacagga
     1981 acatcagcag caggtcggtc agcgacactt cgcccgccag cacgaccttc cacgcttcct
     2041 gcgccatcgc gaacgcggtc gcgagcccga tcacgatcag cccggccagc tcggccgcgt
     2101 gaagaaaatg gccgaagcgg cggcgaatgc gctcggccgg cgagcgggga acggtggtcg
     2161 tattcaaggt gacagtcgcg ttgaggaaac ttgaacggcg ccgggtggcg ggaacgccgc
     2221 gtcgcgcgcg gcagcatgca cggccccgcc atcgggtgcg tcggccgcgt cgggcgcgtc
     2281 gggcgcatcc ggcaccgccg gcgcgtgcgc accggccgcg ccgatcgcct gctcgaccgc
     2341 ggacagcgtc cggcggcagc acacgtggaa cgcgacgccc gcatcggagc aggccacgtc
     2401 gtcgtgctcg cagcacagca gcaggcgaca gccgagatac cgttcgaggc agtcgatccg
     2461 ttcgctcacc tgcgcttcgt cgagccgcag ttcggacgcc gcgccggaca ggccgccacg
     2521 ctcgaccacc gcgacataca cacgcatcgc ttccagcagg ttcatgatga cgctcctcgt
     2581 cggcgggcgc agcggaacct aatctactgc acgcggcatg cacgctcaag agcacagcgc
     2641 cgcgcacgcc aggagtacag ctgcgcgcgc gtcgcccgaa aaccggcccc gtttgacaca
     2701 ttcgcatgac agttcggcga tacgggttcc aaagccccgc cgaagctgct agattgcttg
     2761 ctcgacgacg ttacgcggtg cgggccggtc acgcgccgcg cggccggccg ccaccgccgc
     2821 ggcccgttgc gcgaggcacg cgcaacgtcc ttcatccgca tgacacaaag agaacagtcg
     2881 catgacacag ttcaaccgtt cgccttcgcg cgccacggcc cgcccgtccc gacatgactg
     2941 accggcagcc cgcgatgcag acacctcccc cgctctccca ggccgttcac agcccgatca
     3001 cgcgcagcgc gatcttcctc gtggcgacga tcaatcccgg cgccgagcac gccgacacga
     3061 tccgttcgtg gtgcggcgac atcgccgcgc tcgtgcgctc ggtcggcaag cgtgtgccgg
     3121 gcggcaacct cacctgcgta tgcggcttcg gctccgacgc atgggatgcg ctgttcggcg
     3181 ccccgcgccc cgccgcgctg catccgttcc gcgagttcgg cgcagggcag cgcgtcgcgg
     3241 tcgcgacgcc gggcgacatc ctgctgcaca tccgcgcgga agcgatggac ctgtgcttcg
     3301 aactcgcgac gcagctgctc ggcgcgctcg gcgatgccgt cacggtggtc gacgaggtgc
     3361 acggcttccg caatttcgac cagcgcgcga tgatcggctt cgtcgacggc accgagaacc
     3421 cggaaggccg cgaggcggtc gacttcacgg tgatcggcga cgaagacgcg gaattcgcgg
     3481 gcggcagcta cgtgatcgtg cagaagtacc tgcacgacat ggccggctgg aacgcgctcg
     3541 cggtcgagac gcaggagcgc atcatcggcc gcaccaaatt gtcggatatc gaactcgcgc
     3601 cggacgtgaa gccgtcgtgc tcgcacagct cgctgaccac gctcgacgag aacggccagg
     3661 aagtgaagat cctgcgcgac aacatgccgt tcgggcgccc gggcgcgggc gaattcggca
     3721 cctacttcat cggctacgcg cgctcgccgg cgccgatcga gcagatgctc gagaacatgt
     3781 tcgtcggccg tccgcccggc aactacgacc gcctgctcga ctacagccgc gcggtcaccg
     3841 gctcgctgtt cttcgtgccg tccgccgacc tgctcgaagc gctcgccgat cgcgcggcgc
     3901 cggccgccga cgccgcgcag ccggaagcgt cgccgtccgc gccgcatcgc gacggttcgc
     3961 tgaaaatcgg ttcgctgaaa ggcatcccgt cgtaacgcag ggtaccgatg gccgtccggc
     4021 gcgcgaccgc gcgccgggcg tgtccggaac cgcctctgtt cagtcgggcg gagcgcgcgt
     4081 gcagcgctgc gcaacagtcc cctccaccgc gccaccgctt atgggcagtg acgcgcgcag
     4141 gcttgcattc ccggcacgcc gcccacgcga ctcaacccac cagaatatag agccagttct
     4201 tcggcaacgc cccacccggg ccgttgctgc atgccagcag ccgttcgccg gattgggggt
     4261 gcgtgatgcc ggtacggaac gtctcgatgg ccttgcgctc cagacggtcg aacgcgttcc
     4321 cgaccaggtt gtgcgcttcg agatagatcg gggccatcag cttgaagtcg ggcttggtgg
     4381 cgcgatgttt cgccagccgg gtgtacaggt cgctggtgat gccgatatag aacttgctgt
     4441 actccggctt cgcggcaaac gcgttcaata cctgccgcaa atgcccgatg acatcctcgt
     4501 gattgatgac gcccgtcttc agcatgtatt tgtcttcggg cgagacgagt tgcaatgcca
     4561 tgaacgacct ccactcgttg tgaagcatca ataggctgcg tctatgattc ttccgggccc
     4621 ggctccgacg accgcccaac ccctgccggc agaaacccgg ctggatgaat gttcgtaaga
     4681 atgcacgacg cgcgacagga cgtcgaccgg aattgattcc gcacagcgtc gaacgcggcc
     4741 cgggcgacgg tgccgccggc acgccccggg tatcgcggca atccggtcgc ggcattccgt
     4801 gttcgcccac acccgcaccg cgcgaattgc atcacagttg cgcgaccgca cggtgtcgtt
     4861 tcgatttgtg ctgcagcggt gtcgatcgag cctgctaata ttcattttcg tccgcgatcg
     4921 gcaggctggc atcacgcaca gcccgtcagc cgatcggccc gccatcaagt gtttccgctg
     4981 acgtgaggca atccaaatcc atgaataacc tgcaccgcga actcgccccg atctcgtctt
     5041 ccgcctggga acaaatcgag gaggaagtgg cacgcacgtt caaacgatcg gtggccggcc
     5101 gccgcgtcgt cgatgtcgac ggccccgaag gccccgagct gtcggccgtc ggcaccgggc
     5161 acctggtcac cgtcgacgcg ccgcgcgagc acgtgaacgc gcggctgcgc gaagtccgca
     5221 cgatcgtcga gctgacggtg ccgttcgagt tgagccgcga cgcgatcgac agcgtcgagc
     5281 gcggcgcgcg cgatgccgac tggcaaccgg cgaaggacgc cgcgcagcgg ctcgcgttcg
     5341 ccgaagacaa cgcgatcttc gacggctacc gggccgccgg catcgtcggc atccgcgaag
     5401 gcacgtcgaa ccgcaagctc acgctgccgg cggacgtcag cgcgtatccc gacgcgatca
     5461 gcgatgcgct cgaggcgctc cgcctggccg gcgtcgacgg cccgtattcg gtggtgctcg
     5521 gctcggatgc gtacacggcg ctcagcgagg cgcgcgacca gggttatccg gtcctcggcc
     5581 atatcaaacg gatcgtcagc ggcgagatca tctgggcgcc ggcgatcagc ggcggctgcg
     5641 tgctgtccac gcgcggcggc gattacgaac tgcatctcgg ggaagacgta tcgatcggct
     5701 acacgagcca taccgacaag gtcgtccgcc tgtacctgcg cgaaacgttc acgttcctga
     5761 tgctgacgag cgaagcatcg gtggccgtcg cgccgcaggg caacccaacg gcctgacctc
     5821 ggctgtccgc gcgatgcccg ccgggcgtcg cgcgcggccg gccgcaccgc cggccgcatg
     5881 ttcgtcgccg atcgagccca ctttgcatgg agtgtgtgat gagcgagtcg aatgaggcat
     5941 tacaggcgct gcaggcgtcg gtcgaccagt tgaagcaggc ggtcgacgcg aacgcgagcc
     6001 gccaggccgg cgataccgcc gtgctgttca ccgtcctgtc gctggtcctg gccgagttgc
     6061 cgcccgacac gcgcaacctg atcgaggatt cgttctccgt ctgggccaat ggcctgccgg
     6121 atgcggcact gtcaacggac gtgaagcaga tcgcccggca acggctcgcg atgaccctcc
     6181 cggactgacc gcggcacgcc gcggttgcgc cctgtccggg ccggaccgtg caacccgcct
     6241 gctccttcgg ccgccacaca cgcatcgtcc gcggtgcgtg cgtggctgca tccggccgct
     6301 cgccgcacgt cccccgtgcg gcgcttccat cgcgcccggc cacccgcggc acccgccatc
     6361 cacctgcaac cggcgccctg cgcgcccatg tcgcaccacg ccccgttcgc gtggcgcccg
     6421 ccccgctttc ccgtcaccgc gcgttacgcg cgccgcgcac gcccgcgccg ccgtgcatcc
     6481 gcccgtctgt gctcctcttc gcccgtgcgc gcccgcatcc gagggtgcaa ttcgcggccg
     6541 ggccggcgcg gaactgtgtc ttggatggcc tccgccgatt cgctattttg aacgcagtcg
     6601 aagcgatgcc gtgggctcct cccggcacgc acgcctgccg tcctgaccgc gaccgcgcac
     6661 gacgccggcg cgcactgcgc gacagcccgg gcacggcccg cgcgccgccg tgccgccctg
     6721 cttcatgtcg tgcgttcgcg gtcgggccgc gcaagcgccg caccgcatcg ggacttcacc
     6781 cttcgaccca ctttcaccga caggagccag accaccatgc ccgcactttg cgatatctgc
     6841 cacgcccggc cggccgtcgc gcgcgcaacc gtgatgcagg acggcgagcg caagaccatc
     6901 tcgatctgcg actaccactt ccgtcagctg atgcggcatc aaagcatgct gaacccgttc
     6961 gattcgctgc tgggcggggg cggctcgtcg tcgctgttcg gcgggctcgg tgacgaatcg
     7021 ccgctcgccg ccgaagtgcc gcgcgaatcg gtcgacccga ccgacgcgtt cagcgagcag
     7081 acgctggaac tgctgcagcg cgcggccgag aaggcgcacg agctgcgccg cagcgagctc
     7141 gattccgaac acctgcttta cgcgctcgcg gacaccgacg tgtgcgccgc gctgctgaag
     7201 gaactgaagc tgtcgccgca ggacatccgg tcgtacatcg acgagcacgc gcacaccggc
     7261 acggccgacc ccgatgcgcc gctcgacaag ctgtcgatct cgccgcgcgt gaagaaggcc
     7321 gtacagtacg cgttccaggc gtcgcgcgat ctcggccact cgtacatcgg ccccgagcac
     7381 ctgctgatcg ggctcgcgtc ggtgccggac agcgtcgccg gcacgctgct gaagaaatac
     7441 ggcgtgacgc cggaggcgtt gcgccagaaa gtcgtgaagg tggtcggcaa gggtgccgag
     7501 gacggccgcg tcgatgcgcc gaccggcacg ccgaacctcg acaagttcgg ccgcgacctc
     7561 accgcgatcg cgcgccaggg caagctcgac ccggtgctcg gccgcgcgca ggaaatcgag
     7621 agcacgatcg aggtgctcgc gcgccgcaag aagaacaacc cggtgctgat cggcgagccg
     7681 ggtgtcggca agacggcgat cgtcgaaggg ctcgcgcagc ggatcgtcaa cggcgacgtg
     7741 cccgaggtgc tgcgcgacaa gcggctcgtc gaagtcaaca tcaactcgat ggtggcaggc
     7801 gccaagtatc gcggcgagtt cgaggagcgc gcgaagcagc tgatcgacga agtcacggcg
     7861 aagcaggacg aactgatcct gttcatcgac gagctgcata cgatcgtcgg cgcgggccag
     7921 ggcggcggcg aaggcggcct cgacatcgcg aacgtgctga agcccgcgct cgcgcgcggc
     7981 gagctgagcc tgatcggcgc gacgacgctc aacgaatacc agaagtacat cgagaaggac
     8041 gccgcgctcg agcggcgctt ccagccggtg ttcgtgccgg agccgagcgt cgagcagacg
     8101 atcgtgatcc tgcgcgggct gcgcgacagc ctcgaggcgc atcaccaggt gacgttcgcc
     8161 gacgacgcgt tcgtcgcggc cgcggaattc gccgaccgct acatcacgtc gcgcttcctc
     8221 cccgacaagg cgatcgacct gatcgaccag gccgccgcac gcgtgcggat cggcgcgacg
     8281 tcgcgcccgg tcgacattca ggaaggcgaa gcgcagatcg cgcaactgaa gcgcgagcag
     8341 gactacgcga cctcgcgcaa gcgcttcgac gaagcgaagc agttcgagga gcagatcaac
     8401 gcgaagcaga agtccgtcga cgagaagatg gaggcgtggc agcgcaagac gggctccgag
     8461 acgctcgagg tgacggtcga atccgtggcc gaggtcgtgt cgcgcctgac cggcatcccc
     8521 gtgtccgaac tcacgcagga agaacgccag aagctgctga agatggaaga gcagctgcgc
     8581 gagcgcgtgg tcggccagag cgacgcggtg gtggccgtca gcgatgccgt gcggctgtcg
     8641 cgcgcggggc tcggccagac gcaccggccg atcgcgacgt tcctgttcct cgggccgacg
     8701 ggcgtcggca agaccgagct cgcgaaggcg ctcgccgaga ccgtgttcgg cgacgagcag
     8761 gcgatcatcc gcatcgacat gtccgagtac atggagcggc acgcggtcgc gcggctgatc
     8821 ggcgcgccgc ccggctacgt cggctacgac gaaggcggcc agctcaccga gcgcgtgcgg
     8881 cgccgcccgt acagcgtgat cctgctcgac gagatcgaga aggcgcaccc ggacgtgtac
     8941 aacgtgctgc tccaggtgtt cgacgacggc cgcctgaccg acggcaaggg ccgcgtggtc
     9001 gacttcagca acacgatcat catcgcgacg agcaacctcg gcgccgcgat catcatggac
     9061 aacctcacgc agccggaagc cgcgcgcaag accgacaagg cggtccgcga ggaactgatg
     9121 caggtgctga agggccattt ccgccccgag ttcctgaacc gcatcgacga ggtgatcgtc
     9181 ttccacgcgc tgtcgaagga gaacatccgc tcgatcgtgc agatccagct cgaccgcgtg
     9241 gtccgcacgg ccgccgcgca ggacatcacg ctcgtgatgg gcgattcgct cgtcgagcac
     9301 ctgaccgaag ccggctacca gccggagttc ggcgcgcgcg agctgaagcg ccagatccgt
     9361 cagaccatcg agacgcggct cgccaaggag atcctcgccg accggctgaa gtcgggcgac
     9421 aagtgcgagg tcgactacga caaggacagc aacgaagtga agttcaacaa gctcgccgcg
     9481 cctgaagcga aggaagcgaa agagacgaag gaagccgacg gcaaggccaa gcccaacggc
     9541 aaggccgcca aggcagcaga cgcgaagccg gacgacacgc ccgccgacgc cccgccgccc
     9601 gcggcgaagc ccggcaagaa gacgtccggc gcgaagaagg acgcccacta aaacaacgca
     9661 tgccctgcaa cccggggcac gcatgaccgg ctccgtccgt cggacggagc cgccccacgc
     9721 cgcgacacgg cgcaaccgag ccacccgcac cgggcccggc tattggagat tcaccatgac
     9781 aaatcgacgc gaagtgccag gcatcaggaa gtacgacggg cccgccggcg gttggggcgc
     9841 gcttcgcgcg acagccgacg cggtgcgcac ccagatggag accatcgagg cgccgatcgt
     9901 gctgatgcgg accaaccagc ccgacggctt cgactgcccc ggctgtgcgt ggcccgacaa
     9961 ggaacacaag tcgacgttcc agttctgcga gaacggcgcg aaggccgtca cgtgggaagc
    10021 gacgaccaag cgcgtgacgc ccgagttctt cgccgcgaac accgtgtcgt cgctgctgcg
    10081 catgtcggac tacgaactgg agaacatggg ccggctcacg catccgctcg tctacgaccg
    10141 cgcgaccgac acgttccgcg cgatcgaatg ggacgatgcg ttcgcccgca tcggcgaagt
    10201 gctgcgcgcg ctgccgccgg agcaggtcga gttctacacg tcgggccgcg catcgaacga
    10261 agccgcgtac ctgtaccagc tgttcgcgcg cgagctcggc accaacaact tccccgactg
    10321 ctcgaacatg tgccacgagc cgaccagcgt cggcctgccg cagtcgatcg gcatcggcaa
    10381 gggcaccgtg tcgctggagg atttcgacca ctgcgagctg atcatctcga tcggccacaa
    10441 ccccggcacg aaccacccgc ggatgatggg cacgctgcac gagtgctcgc ggcgcaacgt
    10501 gccgatcatc gtgttcaacc cgctgcgcga gcgcgcgctc gaacgcttcg cggacccgca
    10561 ggacatgatc gagatggcgt cgttcggctc gacgcggatc gcgtcgacgt actaccaggt
    10621 cgatgccggc ggcgacgcgg ccgcgctgaa gggcatcatg aaggcgctgc tgaagctcga
    10681 agccgagcaa ggcaacgtgc tcgaccgcga tttcatcgcg cagcacaccg acggcttcga
    10741 cgcgttctcg gccgacctcg aagccacgtc gtgggacgac atcgaacgcg cgagcggcct
    10801 cagccaggcc cagctc
//
