LOCUS       c00187_NZ_LNAM..        9309 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LNAM01000221.1 Acetivibrio ethanolgignens strain ACET-33324
            ACET-33324.Scaf91, whole genome shotgun sequence.
ACCESSION   NZ_LNAM01000221
VERSION     NZ_LNAM01000221
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:56:40
            Original ID  :: NZ_LNAM01000221.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9309
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9309
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4589:5729](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4590..5729
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..9309
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..9309
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(86..1459)
                     /locus_tag="ctg187_1"
                     /transl_table=11
                     /translation="MAYTKIHAIKATVDKAIDYICNSEKTDEKMYISSYACSPETAAID
                     FKYTLDHCRENSPNKAYHLIQAFAPGEVDFEEAHTIGQELADKVLEGKYSYVVTTHIDK
                     GHVHNHIIFCATDNLEYNKYHDCKQTYYRIRQLSDELCKEHQLSVIIPGENRGKKYKEW
                     QADKNGTAWKPTLRKDINSCIQSSSTYEEFLLLLRARGYEIKGETFDDNAAKYISFRPL
                     DKDRFIRGSIKSLGKEYTKERIKERIEMKRERKAVIPKKDYSSRSLIDTSDEKFQNSPG
                     LKHWAAIENLKIAAQSYNEVGSLSDLEHQIAVKTEAGKSAKQSVVQLEHSMKDLAEIIK
                     YAEQYKANRTYHTGYKKAKNPDAYFRKYESQIILYGGARRMLEQAGINLKGLNIEKLKA
                     EYHRLETQKKELTATYKNCEKEVQDLKRKQENLNRYLGREVSQEHITELTEKDRNQIL"
     PFAM_domain     complement(713..1426)
                     /aSDomain="Relaxase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03432.16"
                     /description="Relaxase/Mobilisation nuclease domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_1_0001"
                     /evalue="9.40E-38"
                     /label="ctg187_1"
                     /locus_tag="ctg187_1"
                     /protein_end="249"
                     /protein_start="11"
                     /score="130.3"
                     /tool="antismash"
                     /translation="TVDKAIDYICNSEKTDEKMYISSYACSPETAAIDFKYTLDHCREN
                     SPNKAYHLIQAFAPGEVDFEEAHTIGQELADKVLEGKYSYVVTTHIDKGHVHNHIIFCA
                     TDNLEYNKYHDCKQTYYRIRQLSDELCKEHQLSVIIPGENRGKKYKEWQADKNGTAWKP
                     TLRKDINSCIQSSSTYEEFLLLLRARGYEIKGETFDDNAAKYISFRPLDKDRFIRGSIK
                     SLGKEYTKERIKERIE"
     CDS             complement(1408..1749)
                     /locus_tag="ctg187_2"
                     /transl_table=11
                     /translation="MANRNRTHPVQFYLDDDEQFILDEKFKLSGMKSKSAFLRKLILYG
                     YVYDVDYSYLRNYNTELGRISSSLNQIAKRVNSTGHIYQEDMNEVKELMNQVWHTQKSM
                     LSKQPLIKR"
     PFAM_domain     complement(1456..1569)
                     /aSDomain="MobC"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05713.13"
                     /description="Bacterial mobilisation protein (MobC)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_2_0002"
                     /evalue="6.40E-07"
                     /label="ctg187_2"
                     /locus_tag="ctg187_2"
                     /protein_end="98"
                     /protein_start="60"
                     /score="29.8"
                     /tool="antismash"
                     /translation="ELGRISSSLNQIAKRVNSTGHIYQEDMNEVKELMNQVW"
     CDS             1945..2100
                     /locus_tag="ctg187_3"
                     /transl_table=11
                     /translation="MEIFTQQTIGIWWEFRLCHDTGSACYSCQEFGINKLQKATKFEKI
                     VDKRRE"
     CDS             2153..2776
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 63.4; E-value: 6.3e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg187_4"
                     /transl_table=11
                     /translation="MARNKYPELTVEKILEVSQRLFLEKGYEQTTIQDIVDNLGGLTKG
                     AVYHHFKSKEEIINALGDKMFLGNNPFNIVKDQDGLNGLQKIQKAMMLNQEDTERATLS
                     RNTIPLLENPRILAGMIESQRKYLSPEFCKLIEEGIKDGSINTEYPKELSEVLPLLELW
                     LMPSIFPASEEELHHKIMFIKELFEHMGVPLFDEQILSMIEEVY"
     PFAM_domain     2192..2335
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_4_0003"
                     /evalue="7.30E-14"
                     /label="ctg187_4"
                     /locus_tag="ctg187_4"
                     /protein_end="61"
                     /protein_start="13"
                     /score="51.4"
                     /tool="antismash"
                     /translation="ILEVSQRLFLEKGYEQTTIQDIVDNLGGLTKGAVYHHFKSKEEII
                     NAL"
     CDS             2868..3596
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.8; E-value:
                     2.5e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg187_5"
                     /transl_table=11
                     /translation="MIEEEVYAVRTHNLFKDYKEKNVISNCNMNVKRGKIYCLVGQNGA
                     GKTTLFKMLLGLTSATQGTAIVLGMDSEKDHLEILSRTGSLIETPVFYEHLSAKENLRI
                     HLEYMKCNNADKIENVLEKVGLKDSSTQIVSTFSLGMRQRLAVARALIHEPELLILDEP
                     VNGLDPVGIRDMRELFRELARQGITILMSSHFLTEVELVADDIGFLCNGTIVQEVPVQD
                     ISKENTGGLENYFMKVIQGA"
     PFAM_domain     2940..3362
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_5_0004"
                     /evalue="1.30E-30"
                     /label="ctg187_5"
                     /locus_tag="ctg187_5"
                     /protein_end="165"
                     /protein_start="24"
                     /score="106.8"
                     /tool="antismash"
                     /translation="SNCNMNVKRGKIYCLVGQNGAGKTTLFKMLLGLTSATQGTAIVLG
                     MDSEKDHLEILSRTGSLIETPVFYEHLSAKENLRIHLEYMKCNNADKIENVLEKVGLKD
                     SSTQIVSTFSLGMRQRLAVARALIHEPELLILDEPVN"
     CDS             3601..4314
                     /locus_tag="ctg187_6"
                     /transl_table=11
                     /translation="MKINKIFSLELERNGLREYKIAALISTFFLLGFIYLIVAIPKIDP
                     GDSDAELFASYHFVTGLTLVVMMGIFSVISATMSSKIVVDEYCGKKAILLFSYPISRER
                     IMETKLLVVFLFTVISMLISGTIIFAVFFTTEIFIPISEDIVSPELILTSVLYLVCYAM
                     ISAFCGIVSSWIGFRKQSVIATIVASCIIMVLMCQIAAMTFFAWAVMIVLLAVMGTVTF
                     LAIKNMLSQVNKMEI"
     CDS             4590..5729
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg187_7"
                     /sec_met_domain="ThiF (E-value: 2.4e-52, bitscore: 167.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 2e-14,
                     bitscore: 43.2, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSILYNRPRIKPIYPLYRLNSKEFRIGAQLGITAEFGDPEGQLWE
                     LASRLDGRPVMEVVEEVREVFPELTVEDVIEGIELLDNEGFIEECLEEEADVPVRYMPN
                     INYFSRYIGSQGNRYTPHRKISETTILLLGLGGGGSNILTMLAGLGPKKIVIVDYDNVE
                     ESNLGRQLLYKESDIGTPKAEAAARTISEMNKDILIEAHNKKIEKPEDVLDVIEGVDLV
                     ICAIDEPPFVAQRIVNEAIVKANVPCVFGASQVSRGRVFTVIPGVTGCFDCLNLHYSMN
                     DPQFVEQFVAFRKIDFNPPTIAYAPAIFQLTAAIVDEAVRVITGYAEPRSLGTQYEINF
                     EDGSSFRHPSWKRYAEKCPTCGKGKKSDWEIFQYYENKK"
     PFAM_domain     4956..5666
                     /aSDomain="ThiF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00899.23"
                     /description="ThiF family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_7_0005"
                     /evalue="1.60E-45"
                     /label="ctg187_7"
                     /locus_tag="ctg187_7"
                     /protein_end="359"
                     /protein_start="122"
                     /score="155.1"
                     /tool="antismash"
                     /translation="RKISETTILLLGLGGGGSNILTMLAGLGPKKIVIVDYDNVEESNL
                     GRQLLYKESDIGTPKAEAAARTISEMNKDILIEAHNKKIEKPEDVLDVIEGVDLVICAI
                     DEPPFVAQRIVNEAIVKANVPCVFGASQVSRGRVFTVIPGVTGCFDCLNLHYSMNDPQF
                     VEQFVAFRKIDFNPPTIAYAPAIFQLTAAIVDEAVRVITGYAEPRSLGTQYEINFEDGS
                     SFRHPSWKRYAEKCP"
     CDS             5738..6649
                     /locus_tag="ctg187_8"
                     /transl_table=11
                     /translation="VYGEEKMTLKKIFSRKLKNGNYVILAADSEPLVVEEFALCISLDR
                     SVLANCDENVITTFKDSGFFADTLLDVDAVIPEEPKGKKWNVLRQGMIIISVIALFCVL
                     VCIPFTGIPIGNRIIPANVPMWLSVAFMVVFSVVTTILHELMHMLYAKTWKRQNGGVKI
                     VLKKSMATVTMTHIWVWSFWGRMAAVSAGIMSDLLILCFCSMIGLYKDSWIVSAAASIL
                     WVRILWQFRFHRKTDGRFILMLLLDNPVIALEGESDTDFSDKKDILIWKLFQVIGVFVG
                     LAIVAFWGIPFLLSIFSNLFSF"
     CDS             6665..7591
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 163.8; E-value:
                     8.8e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg187_9"
                     /transl_table=11
                     /translation="MKEKKLIIDSISKTYKKGKVKANDNISLELHPSEVTALIGHNGAG
                     KTTLLNQIIGNVKPDSGDITYGGISLVNNSKAARELVSMMPQFHVSLEGVTLRQSIESI
                     LRIKGVPEKQVQLYTKQILRDLDIEQWAEQAGNKLSGGLQRLTSFAMAVAYPSDIILLD
                     EPTNDVDPIRRKLVWQYMRKLAKNGHMIFVVTHNLLEVEQYTDRYILMNKGRMIRNVST
                     TVMSNDFASNIMIVYLHDVDELHGLPENEASEYKKDEMQLILTLSEKQVPGAVKWLLEL
                     MGQGKVLNYKLTSATLDMQYGGMIDGE"
     PFAM_domain     6734..7165
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_9_0006"
                     /evalue="2.70E-26"
                     /label="ctg187_9"
                     /locus_tag="ctg187_9"
                     /protein_end="167"
                     /protein_start="23"
                     /score="92.8"
                     /tool="antismash"
                     /translation="DNISLELHPSEVTALIGHNGAGKTTLLNQIIGNVKPDSGDITYGG
                     ISLVNNSKAARELVSMMPQFHVSLEGVTLRQSIESILRIKGVPEKQVQLYTKQILRDLD
                     IEQWAEQAGNKLSGGLQRLTSFAMAVAYPSDIILLDEPTN"
     CDS             7581..8345
                     /locus_tag="ctg187_10"
                     /transl_table=11
                     /translation="MVNEEILSKPKVSYFTKLKGVILWSLIRHKYLVPVFSVAQAAFSV
                     AIICGMALFLPQLDDTSVVYLASGALTLGMIAVGCVLAPQIVSEGKQNGIFEYQRTLPV
                     SRSIILLADIIIWGIASLPGVIMGCVASMLRFDINLNITVQSCLVILLTQFTMICIGFC
                     IAYWLPPNAMALATQVIMIGGLLFSPITYPAERLPEWSMYIYNVLPFVPMSNLIRASLF
                     LTKPMDVSDLIVVIFWAVAAFVLSLCALSKKE"
     PFAM_domain     7659..8246
                     /aSDomain="ABC2_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01061.26"
                     /description="ABC-2 type transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_10_0007"
                     /evalue="5.30E-12"
                     /label="ctg187_10"
                     /locus_tag="ctg187_10"
                     /protein_end="222"
                     /protein_start="26"
                     /score="45.7"
                     /tool="antismash"
                     /translation="IRHKYLVPVFSVAQAAFSVAIICGMALFLPQLDDTSVVYLASGAL
                     TLGMIAVGCVLAPQIVSEGKQNGIFEYQRTLPVSRSIILLADIIIWGIASLPGVIMGCV
                     ASMLRFDINLNITVQSCLVILLTQFTMICIGFCIAYWLPPNAMALATQVIMIGGLLFSP
                     ITYPAERLPEWSMYIYNVLPFVPMSNLIRASLF"
     CDS             8407..9219
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg187_11"
                     /sec_met_domain="Abi (E-value: 1.8e-17, bitscore: 53.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPNSLAVILSVNLIMVFVIEIIKIAFFRGSLIEEDIAMLIQLYG
                     SIIGIGLVILYCYGIEKRKLACMGIIRSSFFQQYMKGILVGGFLISVIVLIGELLGIFV
                     FDKINQNLNIKIILLFFFGFLLQGFYEELVFRGFLMISIIKKSTIFVAVMINSLLFGLT
                     HGFNDGIHVLGLLNLILFGIFESIYLLKNGNIWGVSAIHSMWNFMQGSIYGFNVSGMAQ
                     SQSLLTFKIKNCEIFSGGTFGLEGSLLTTIVLASGILIAALYKNRMHE"
     PFAM_domain     8752..9030
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg187_11_0008"
                     /evalue="1.10E-13"
                     /label="ctg187_11"
                     /locus_tag="ctg187_11"
                     /protein_end="208"
                     /protein_start="115"
                     /score="51.4"
                     /tool="antismash"
                     /translation="IILLFFFGFLLQGFYEELVFRGFLMISIIKKSTIFVAVMINSLLF
                     GLTHGFNDGIHVLGLLNLILFGIFESIYLLKNGNIWGVSAIHSMWNFM"
ORIGIN
        1 caatcagttc cattttagga gttggttgta aaaaagggtg aacttcacgg attcaggtat
       61 aatacaaggt ctggttctta acaagctata agatttgatt tctgtctttt tcggtcagtt
      121 ccgtaatatg ttcctgtgat acttctcgtc caagatagcg gttgagattt tcctgcttcc
      181 gtttcaaatc ctgtacctct ttttcacaat ttttataagt tgcggtcagt tcttttttct
      241 gtgtttctaa tctatgatat tcagctttta acttctcaat attcaatccc ttcagattga
      301 taccagcctg ctctaacata cgtcttgcac cgccataaag gataatctga ctttcgtatt
      361 tgcggaaata agcatccgga tttttggctt ttttgtagcc ggtatggtag gtacggtttg
      421 ccttatactg ctcggcatat ttgataattt ctgcaaggtc tttcatgctg tgttccagtt
      481 gtacgacact ttgttttgca gattttccgg cttcggtttt tactgcaatc tgatgttcta
      541 aatcagataa agaacccact tcattatagc tttgtgcagc tatttttaaa ttctcaatag
      601 cagcccaatg tttcagtccg ggactgttct gaaacttctc gtcagaagta tcaatcagac
      661 tgcgtgagct gtaatccttt ttaggaatga cagcttttcg ttcccgtttc atttctatgc
      721 gttctttgat acgttctttt gtatattctt ttcctaaaga ttttatgctg ccacgaataa
      781 aacggtcttt atccaaaggg cggaaagaaa tatattttgc tgcattatca tcaaaagttt
      841 cgcccttaat ctcatatccc cttgctctta gtaaaagcaa aaattcttca taagtggaag
      901 aagattggat gcaggaattg atgtcttttc gcaaggtcgg tttccatgct gtgccatttt
      961 tatcagcttg ccattcctta tattttttgc cacgattttc tccgggaata ataacggaaa
     1021 gctggtgttc tttgcacagc tcgtcactta actgtcggat gcggtaatag gtctgtttgc
     1081 agtcatgata tttgttatat tcaaggttat cggtagcaca aaatatgatg tgattatgta
     1141 catgaccttt gtcgatatgg gtagtaacaa cataggaata tttcccctct aaaaccttgt
     1201 cagcaagttc ctgtccgatt gtgtgagctt cttcaaaatc aacctcgccg ggtgcaaaag
     1261 cctgtatcag atgataggct ttgtttggac tgttttccct gcaatggtcg agggtatatt
     1321 tgaaatcaat cgcagcggtt tccggagaac aggcataaga ggaaatatac attttttcat
     1381 cggttttttc tgaattacag atatagtcta tcgctttatc aacggttgct ttgatagcat
     1441 ggatttttgt gtatgccata cctgattcat caactccttt acctcgttca tatcttcctg
     1501 atagatgtgt ccggtgctgt tcacacgctt tgcaatctgg ttcagactgg aactaatccg
     1561 tccgagttcc gtattgtaat ttcgcagata actgtaatcc acatcataaa catatccgta
     1621 taaaatgagc ttacgcagaa aagccgattt gcttttcatg ccagataatt tgaacttctc
     1681 atcgaggata aactgctcgt catcatcaag ataaaattgc accggatggg tgcggtttct
     1741 gtttgccata gtgttacgtc ctttctaaaa atgggtacaa aaaaactgct gtaaaatgtt
     1801 cgattattac aacagttgtt ttcatgtttt attcagtttc gggcaaaagt actcaagaca
     1861 aattgtagca aaagcagaag aaaaggtcaa gaagtttaga gaaaaagctg atagatttct
     1921 ttagagggtt agggatactt ccctatggaa atttttacac agcagacgat aggaatatgg
     1981 tgggaatttc gcctgtgtca tgacacaggc agtgcttgct attcttgtca agaatttggt
     2041 ataaataagc tacaaaaagc tacaaagttt gagaaaatag ttgacaagag aagggaatag
     2101 tgatataaat acatacatat cgaatgtatt tatgaaatca ggtggaaact atatggcaag
     2161 aaacaaatat ccggaattaa cagtggaaaa aatattggaa gtatcgcaaa gacttttttt
     2221 agagaaagga tacgaacaaa caacaattca ggatatcgtt gataacttag gaggactgac
     2281 caaaggagca gtatatcatc attttaaatc taaagaagag attatcaatg ctttagggga
     2341 taaaatgttt ttgggtaaca acccgtttaa tatagtgaaa gaccaagatg gattaaatgg
     2401 attgcagaaa attcaaaaag ccatgatgtt gaatcaggaa gatacggaga gagccacatt
     2461 atcgagaaat acaattccgt tgttagagaa tcctcgaata ttagctggga tgatagaatc
     2521 acaaagaaaa tatttgtcac cagagttttg caaattaatt gaagaaggta tcaaagatgg
     2581 ttctatcaac acagaatatc cgaaagaatt atcagaagtt cttccactat tggaactgtg
     2641 gttgatgcca tctatatttc cagcatcgga agaagagtta catcataaga ttatgttcat
     2701 caaagaattg tttgagcata tgggagttcc gctttttgat gagcagatat tatcaatgat
     2761 agaagaagtg tattgatgta aataataaaa tgaaattgtg tcgtgcagtt ttattttatt
     2821 ttttacatca atacatacat accgaatgta tgaaaggaga aaatgatatg attgaggaag
     2881 aagtgtatgc ggtaagaacg cataacttat ttaaagatta taaagaaaaa aatgtaataa
     2941 gtaattgtaa catgaatgta aaacggggaa agatatattg tctggtgggt caaaatggtg
     3001 caggaaagac tactctgttt aagatgttgt tgggattaac aagtgctacg cagggaacag
     3061 caatcgtttt gggaatggac tctgaaaaag accatctgga aatcctctcc agaacaggaa
     3121 gtcttataga aactcctgtt ttttatgaac acctttcagc aaaggaaaac ttaaggatac
     3181 atttggaata tatgaagtgt aataatgctg acaaaattga aaatgtattg gaaaaggtag
     3241 gtttgaagga ttcatcaact cagatagtat ctactttttc attaggaatg cgtcagagac
     3301 tggctgttgc gagagcactg atacatgaac ctgagttact gattctggat gaaccggtta
     3361 atggattaga tccggtggga atacgggata tgagagagtt gtttcgtgaa cttgcaaggc
     3421 agggaatcac aattttaatg tccagtcatt ttctgacaga agtggaactg gttgcagatg
     3481 atataggatt tctgtgtaat ggaacaatcg tgcaggaagt tccggtacag gatatatcaa
     3541 aagagaatac cggtggattg gaaaattatt ttatgaaagt aattcaagga gcgtgagaag
     3601 atgaaaataa acaaaatatt ctctctggaa ttagagagaa atggtttgcg ggaatataag
     3661 attgcggctt tgataagtac cttttttcta ttggggttta tatatttaat agtagcgata
     3721 cctaaaattg atccaggaga tagcgatgca gaattatttg cttcttatca ttttgtgaca
     3781 ggattgacac tggtagtgat gatgggaata ttttcagtaa tttctgcaac gatgtcatca
     3841 aagattgttg ttgatgaata ttgcgggaaa aaggcaattt tgctgttttc ctatcctatc
     3901 agtcgggaaa ggataatgga aacaaagctg ttagtagtgt ttttgttcac agttatttca
     3961 atgcttataa gcggaaccat aatttttgct gtatttttta caacagaaat ctttattccg
     4021 attagtgagg acattgtcag tccggaactg atattgacaa gcgtactgta tttggtgtgt
     4081 tatgccatga tttctgcctt ttgtggtatt gtttcaagct ggattgggtt cagaaagcag
     4141 tctgtgattg caaccatagt tgcttcctgt attattatgg ttttgatgtg ccagatagca
     4201 gccatgacat tttttgcttg ggcagttatg atagtgcttt tggctgtaat gggaaccgtt
     4261 acatttttgg ctataaaaaa tatgttgagt caggttaata aaatggaaat ttagcttagc
     4321 gtataatgtt cttttatata ctctcaaaga gtggcgaaag gatgtataca tataaagagt
     4381 gctgatagta gtagggcatt cagtatggaa gggaggaggt gagactatga aaaacattac
     4441 agttcgtcgt gctgtcaagg ttgacgcaac agcatggtgg atcgttttct aagacgattc
     4501 agtaggttga tagtgccgga gacaaactga gttttcagtt tgtctttggt gctatatacg
     4561 agaattagca aaggagaaga gtgataaata tgagcatatt atataacaga ccaagaatta
     4621 agccaatcta tccgctgtac agattaaata gtaaggaatt tcgaataggg gctcagctcg
     4681 gaattacagc agaatttgga gatccggaag gacagctatg ggaactggcg tcaagacttg
     4741 acggcagacc agttatggaa gtagtggaag aagtgcggga ggtatttccg gaactgacag
     4801 tagaggatgt gatagagggt atagaacttt tagacaatga gggttttata gaggaatgtt
     4861 tggaggaaga agctgatgta ccagttaggt atatgcctaa tataaattat tttagcagat
     4921 atataggaag tcagggaaat agatatacac cgcatagaaa aattagtgaa acaacaattc
     4981 tcctactcgg attaggcggt ggtggttcca acatacttac aatgcttgca ggactcggtc
     5041 cgaaaaagat tgtaattgtg gactatgaca atgtagaaga gagtaatttg ggcagacagc
     5101 ttttatataa ggaatcagat attggaacgc cgaaagcaga agcagcagca agaacaattt
     5161 cggagatgaa caaagatatt ctgattgagg cacacaataa gaagatagaa aaaccagaag
     5221 atgtattaga tgtgatagaa ggtgtagatc ttgttatatg tgcaatagat gaacctcctt
     5281 ttgttgcaca aagaatcgta aatgaagcga ttgtgaaagc aaatgtacct tgcgtttttg
     5341 gagcatcaca ggtaagcaga ggaagagtat ttacagtaat tccaggtgtg actggttgtt
     5401 ttgattgttt aaatcttcat tatagtatga atgatcctca gtttgtggaa caatttgttg
     5461 cttttaggaa aatagatttt aatccaccaa ccatagcgta tgcacctgca atatttcaac
     5521 ttacagcagc gattgttgat gaggcggtgc gtgtaataac gggatatgca gaacctcgca
     5581 gtctgggaac acagtatgaa attaattttg aagatggttc ttcattcagg catccttcat
     5641 ggaagcgtta tgcagaaaag tgcccaacct gcggaaaggg gaaaaaatca gactgggaga
     5701 tatttcaata ttatgaaaat aaaaagtaag atatagagtg tacggtgaag aaaaaatgac
     5761 tttgaaaaaa atattttcaa gaaaattaaa aaatgggaat tatgtgatat tagctgctga
     5821 ttctgaaccg ctggtagtag aagagtttgc attgtgtata agtctggata gaagcgtatt
     5881 agcaaattgt gatgaaaatg ttattaccac atttaaggat agtggctttt ttgcggatac
     5941 gttattggat gtagatgcag ttattccgga agaaccaaaa gggaaaaagt ggaatgtgct
     6001 aaggcagggg atgataataa tatcagtcat tgcattgttt tgtgtgttag tgtgtattcc
     6061 atttaccggg attccgattg gaaatagaat tatacctgcc aatgttccaa tgtggctgtc
     6121 ggttgcattt atggtagtat tttcggtggt cactacaatt cttcacgaat tgatgcacat
     6181 gttgtatgca aaaacatgga aaaggcagaa tggtggggta aaaattgtat taaaaaagtc
     6241 tatggctaca gttaccatga cacatatatg ggtgtggtca ttttggggga gaatggctgc
     6301 cgtatcagcc ggaatcatgt ccgatttgtt gatattatgt ttttgttcaa tgattgggtt
     6361 gtataaggac agttggattg tttcggcggc agcttcaatc ctttgggtaa gaatattatg
     6421 gcagtttcgt tttcacagaa agacggatgg acgttttata cttatgcttt tgttagataa
     6481 tccggtcatt gcacttgagg gtgagagtga tactgatttt tctgataaaa aagatattct
     6541 gatatggaaa ttgtttcagg taattggagt ttttgttggg ttagcaatag ttgctttttg
     6601 gggtatccca tttttattaa gcattttttc taatctgttt agtttttaga aagagagaga
     6661 attgatgaaa gaaaaaaagt tgattattga ttcgattagt aaaacatata aaaaaggaaa
     6721 agtaaaagct aatgataata tttcgttaga actgcaccct tcagaagtta ctgcacttat
     6781 tggacataat ggtgcaggga aaacaactct gctgaatcaa attataggta atgtcaagcc
     6841 tgacagtgga gatattactt atgggggaat atcattagtg aataattcaa aagcagccag
     6901 agaactggta tccatgatgc cacagtttca tgtttcgctt gaaggagtaa cattaaggca
     6961 gtccatagaa tctattttaa gaattaaggg agtacctgaa aaacaggtgc aattatacac
     7021 aaagcagata ttaagggatt tagatattga acagtgggcg gaacaggcgg gaaacaaatt
     7081 atccggtggt ttgcaacgat taacttcttt tgcaatggca gtagcatatc catccgatat
     7141 tattctgctt gacgaaccga caaatgatgt tgatccgata cgccggaagt tggtatggca
     7201 atatatgagg aaactggcaa aaaacggaca tatgattttt gttgttactc ataatctgct
     7261 tgaagttgag cagtatacag acagatatat tttgatgaac aaagggcgta tgatacgaaa
     7321 tgtttctacg acagttatga gtaatgattt tgcgtcaaat attatgattg tgtacttaca
     7381 tgatgtagat gaattgcatg gtttgccgga gaatgaagcg agcgaatata aaaaagatga
     7441 aatgcaactt attcttactt tgtctgaaaa gcaggttccg ggtgcggtta agtggctgct
     7501 ggagcttatg gggcaaggaa aagttttgaa ttataagctt acatctgcaa cattggatat
     7561 gcaatatgga ggaatgatag atggtgaatg aagaaatatt atcaaaaccg aaggtgtctt
     7621 attttacaaa actcaaggga gtgatactgt ggagcctgat aagacataaa tatctggtgc
     7681 cggtattcag tgtggcacag gctgcatttt cggttgcaat tatatgtgga atggcattat
     7741 ttcttccaca gcttgatgat acatcagttg tttatttggc atcgggtgca ttgactttgg
     7801 ggatgattgc agtcggctgt gttttagcac cacagattgt aagcgaggga aaacaaaatg
     7861 ggatatttga atatcaaaga acgcttccgg tttcaagaag cattattttg ttggcagata
     7921 ttatcatatg gggtattgct tcgctgccgg gtgtgattat ggggtgcgtt gcttctatgt
     7981 tgcgttttga tataaacctg aatataacag tacaaagctg cctggttatt ttacttacac
     8041 agtttacaat gatttgcatt gggttttgta ttgcatattg gcttccaccg aatgccatgg
     8101 cattggcaac acaggtaatt atgataggcg ggctgctttt ttcaccgata acatatccag
     8161 cagaaagact tccggagtgg tctatgtata tctataatgt gctgccgttt gttcctatga
     8221 gtaatttaat aagggcgagt ttgtttttga caaagccaat ggatgtatca gatttgattg
     8281 tagttatttt ttgggctgtt gcagcgtttg ttctttccct ttgtgctttg tcaaaaaaag
     8341 aatgaaaatt gaaattcgca gagagtttac aagagtgaat atacagccaa tggataggta
     8401 aatgatatgt taccgaattc attggctgtt atcctgtctg ttaatctgat aatggtattt
     8461 gtgattgaga taataaaaat agcatttttt cggggaagtt tgattgaaga agatatagcc
     8521 atgcttattc aactatatgg aagtattatc ggaattggct tggttatact gtactgttat
     8581 ggaattgaaa aaagaaaact tgcgtgtatg ggaattataa gaagctcttt ttttcaacag
     8641 tatatgaaag gtattttggt aggaggtttt ctaatatcgg tcatagtgct gataggagaa
     8701 cttttgggga tttttgtatt tgataaaatc aatcagaatt tgaacataaa gattatatta
     8761 ttattttttt tcggtttctt attgcaggga ttttatgaag aattggtatt tcgtggcttt
     8821 ttaatgattt ccattatcaa aaaaagtacc atatttgtag cagtaatgat taattctttg
     8881 ctttttggat taacacatgg ttttaatgat ggaattcatg tgcttgggtt gcttaatttg
     8941 atattatttg gaatatttga gtcaatttac ttgttaaaaa acggtaatat ttggggagtc
     9001 agtgccatac atagtatgtg gaattttatg cagggatcta tttatggttt taatgtatca
     9061 ggaatggcac aatcacaaag tttgctgaca tttaaaatta aaaattgtga aatttttagt
     9121 gggggaacat ttggattgga agggagtttg ctgacaacaa tagtattagc aagtggtatt
     9181 cttatagctg cactatataa aaatagaatg catgaataaa tagaaaaata ggaatataaa
     9241 aaatctgtaa gtaactattc agtaccccgt taagggcact tttatttttg ggcaaaacag
     9301 agaaaataa
//
