LOCUS       c00131_NZ_LNAM..       14336 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_LNAM01000165.1 Acetivibrio ethanolgignens strain ACET-33324
            ACET-33324.Scaf40, whole genome shotgun sequence.
ACCESSION   NZ_LNAM01000165
VERSION     NZ_LNAM01000165
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:56:40
            Original ID  :: NZ_LNAM01000165.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14336
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14336
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3639:4336]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3640..4336
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..14336
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14336
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             103..852
                     /locus_tag="ctg131_1"
                     /transl_table=11
                     /translation="MLSEDELQVVDIKAENLILEDTNVELRTYADCDSYREKLLSGTKS
                     YVRIYWNDGVETQEPVQWEKITEEDLAQIHSGKTITKVGYVPSIQQNVTMKIGPRAYSM
                     ENLSGVRGMKDLDYVFDGLINEAAGTPSGEFKGFDFSNNRASIIYDFQETVNLKGMDIW
                     CNYGNDQGIKKMKVAVWDEEQERWVILKDEDGTEQEFIMNWQTAVQVAEKQSIAFPGVD
                     TKKVKIIILDAGYKWNKFSIREIEFQS"
     CDS             1082..1255
                     /locus_tag="ctg131_2"
                     /transl_table=11
                     /translation="MSNVIVKENETLDSALRRFKRNCAKAGIQQEIRKREHYEKPSVRR
                     KKKSEAARKRKF"
     aSDomain        1088..1249
                     /aSDomain="TIGR00030"
                     /aSTool="tigrfam"
                     /description="S21p: ribosomal protein bS21"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg131_2_0001"
                     /evalue="5.50E-23"
                     /identifier="TIGR00030"
                     /label="ctg131_2"
                     /locus_tag="ctg131_2"
                     /protein_end="56"
                     /protein_start="2"
                     /score="78.6"
                     /tool="antismash"
                     /translation="NVIVKENETLDSALRRFKRNCAKAGIQQEIRKREHYEKPSVRRKK
                     KSEAARKRK"
     PFAM_domain     1091..1252
                     /aSDomain="Ribosomal_S21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01165.22"
                     /description="Ribosomal protein S21"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_2_0001"
                     /evalue="4.90E-23"
                     /label="ctg131_2"
                     /locus_tag="ctg131_2"
                     /protein_end="57"
                     /protein_start="3"
                     /score="80.7"
                     /tool="antismash"
                     /translation="VIVKENETLDSALRRFKRNCAKAGIQQEIRKREHYEKPSVRRKKK
                     SEAARKRKF"
     PFAM_domain     1563..1787
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_3_0002"
                     /evalue="5.50E-12"
                     /label="ctg131_3"
                     /locus_tag="ctg131_3"
                     /protein_end="75"
                     /protein_start="0"
                     /score="45.9"
                     /tool="antismash"
                     /translation="LENCKKQTIDLVFLDLEMPECNGFELAEQIYDFNQAIKIIFVSNH
                     ENMVFDSYEYAPLWFVRKSFMERDMLKAIQ"
     CDS             1563..2153
                     /locus_tag="ctg131_3"
                     /transl_table=11
                     /translation="LENCKKQTIDLVFLDLEMPECNGFELAEQIYDFNQAIKIIFVSNH
                     ENMVFDSYEYAPLWFVRKSFMERDMLKAIQKYLQMETKVQIWCKSGEGTKDIWLYINKV
                     LYIECSGHTLSIHMKNKECHKIYGSLKSLEEKLHTYGFVRIHKNFLVNARCVKEIGNRT
                     VCLPDGIELDIGKNRRKEIKQLLENYNGGRRMC"
     PFAM_domain     1860..2120
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_3_0003"
                     /evalue="4.10E-18"
                     /label="ctg131_3"
                     /locus_tag="ctg131_3"
                     /protein_end="186"
                     /protein_start="99"
                     /score="65.5"
                     /tool="antismash"
                     /translation="YINKVLYIECSGHTLSIHMKNKECHKIYGSLKSLEEKLHTYGFVR
                     IHKNFLVNARCVKEIGNRTVCLPDGIELDIGKNRRKEIKQLL"
     CDS             2167..3456
                     /locus_tag="ctg131_4"
                     /transl_table=11
                     /translation="LINGLSSVIALEYISHGLKQKYRGYRGTVLFLAGCTAYFFVVTGL
                     NHYTNFEGVLGIGYGVVLYVYCLLAAQGKKSDFFLLSVVWVLLAFISAYVMFALWGIFS
                     GGSLEELLKTESQAHMYFSLSAGALRFSLGRIVLAVYRRRKQKKLLAEDWMMALIFFIF
                     FFLILFMFRLERGGLDQKERYNLSLWILLGIFLVILLLGGFYQLIGKYRIEKIAEEYRK
                     ENQKLQEEQIHNLYQLGREANRLRHDMGAKVNVVYEQLRKKDYQEAEENLKRIGDEWED
                     YLEIPEETGNEGLNAALIRAIHECRGKDIRFHYAVLGSVSGVDSLDMGNLIHNLLKNGI
                     EACDKVQGKRELEIVIRRDGFMVEIEIDNTIQDSVMDWNPSFKTSKIEKEKHGFGMETI
                     RRIVEYYDGDYIAWEEGERLLQRITLKIEK"
     PFAM_domain     3139..3441
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_4_0004"
                     /evalue="1.50E-15"
                     /label="ctg131_4"
                     /locus_tag="ctg131_4"
                     /protein_end="425"
                     /protein_start="324"
                     /score="57.0"
                     /tool="antismash"
                     /translation="SLDMGNLIHNLLKNGIEACDKVQGKRELEIVIRRDGFMVEIEIDN
                     TIQDSVMDWNPSFKTSKIEKEKHGFGMETIRRIVEYYDGDYIAWEEGERLLQRITL"
     CDS             3640..4254
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg131_5"
                     /sec_met_domain="AgrB (E-value: 1.1e-38, bitscore: 123.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLERISIYLSTLLLQEKIITVDEKDTYKYGLEITMANIINGFIVL
                     IIGVVLNLLVESILFYLVFVSLRFFCGGYHADSYTKCFFSFAFTTIVCLVISERLAQYE
                     EIIQGLFFITAVMLGEHILKMAPIEHENRPLTEEEKNLFRKRSVQVLVFWIAIGIILWM
                     GHLVQMETSLISAFIAVTILMRIGGIGYYEKRSASGVGKSS"
     PFAM_domain     3670..4185
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_5_0005"
                     /evalue="7.70E-36"
                     /label="ctg131_5"
                     /locus_tag="ctg131_5"
                     /protein_end="182"
                     /protein_start="10"
                     /score="123.2"
                     /tool="antismash"
                     /translation="TLLLQEKIITVDEKDTYKYGLEITMANIINGFIVLIIGVVLNLLV
                     ESILFYLVFVSLRFFCGGYHADSYTKCFFSFAFTTIVCLVISERLAQYEEIIQGLFFIT
                     AVMLGEHILKMAPIEHENRPLTEEEKNLFRKRSVQVLVFWIAIGIILWMGHLVQMETSL
                     ISAFIAVTI"
     CDS             4214..4336
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg131_6"
                     /sec_met_domain="TIGR04223 (E-value: 2.8e-08, bitscore:
                     24.5, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKREVLQVLAKVANSAAKRADGRASEFGMHQPKRPKKIKK"
     aSDomain        4229..4333
                     /aSDomain="TIGR04223"
                     /aSTool="tigrfam"
                     /description="quorum_AgrD: cyclic lactone autoinducer
                     peptide"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg131_6_0002"
                     /evalue="5.10E-06"
                     /identifier="TIGR04223"
                     /label="ctg131_6"
                     /locus_tag="ctg131_6"
                     /protein_end="40"
                     /protein_start="5"
                     /score="24.5"
                     /tool="antismash"
                     /translation="LQVLAKVANSAAKRADGRASEFGMHQPKRPKKIKK"
     PFAM_domain     4469..4990
                     /aSDomain="VWA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00092.30"
                     /description="von Willebrand factor type A domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_7_0006"
                     /evalue="1.50E-15"
                     /label="ctg131_7"
                     /locus_tag="ctg131_7"
                     /protein_end="174"
                     /protein_start="0"
                     /score="58.0"
                     /tool="antismash"
                     /translation="MFVMDYSGSMKTNDSQDIARGMVKAFVDTVHSADIRVGFVAYNDR
                     ILTSTSPLTIQTTEERAQLKELIGQEQYAGNTDIGLGLSYGYELLGEPSGRKQVIVLIS
                     DGEADLKGSDTGRSTEISRQDMRSVAQKCAKTGTKIYTIVFGDYDGNTEALKEISKNTL
                     AQMYAAETPES"
     CDS             4469..6382
                     /locus_tag="ctg131_7"
                     /transl_table=11
                     /translation="MFVMDYSGSMKTNDSQDIARGMVKAFVDTVHSADIRVGFVAYNDR
                     ILTSTSPLTIQTTEERAQLKELIGQEQYAGNTDIGLGLSYGYELLGEPSGRKQVIVLIS
                     DGEADLKGSDTGRSTEISRQDMRSVAQKCAKTGTKIYTIVFGDYDGNTEALKEISKNTL
                     AQMYAAETPESLIEVLYGIFGTNMDYSIQEIADSLFAPGIQNIRISLEENYLDEMDVLL
                     ISPRKIGDVGILYGDREIETINLGNYAVGKITDIDSSIRELTLQAETLENQKLQIYLFS
                     YRSLTPVLELDTTVCKNEPLSYKLYFRDKSGNTVSDEKLYENFIYEFSINDGEKKDTPE
                     RFLNIEPSNGYMQGQAIMEQSGTWFFQAYMEDSMGNSSFKPIPVVVENRKPNGALPADE
                     GFTVLTREQFYLLDEYFTDPDGDQLSYLLKTDPGKYLDIELVNNVLTIHPLKSGTQTIL
                     LEVSDGESTYTYEHEIEIMPLWKVYGWVFVLLAGGVIGAVIWKIMHKSKPDLERLTKET
                     KKNHFCGRMNAYFTAQPDAEKEIPPLSFELYKVRENRLALGALLEGYPDAVRAMELNEI
                     HLMADEDRRMILYHTSKSVIMIGNSIACKQIQYSVGFGDVIYIMPQDGSYELEIHYIAM
                     IQ"
     CDS             6446..8590
                     /locus_tag="ctg131_8"
                     /transl_table=11
                     /translation="LFAEINPERENILTLIGDVRGKNSLDDDKMKEINEELLVSSFDEF
                     LEKMSPVVYSYCDANTGEMKYSLVRPENIPDNCITEIPLNENNDLLNMLITLLEAKSAQ
                     GVANVDFTFSNVLDMISPKKIMEDIRQVRREIQYTYEKYVQLDDEDPKKLDLGDRLNDQ
                     FEQASQNYNHVLAMLPLAIEDAKTRLLLGDGETKQGSQEFKAGLLSMGEDGELKILEMQ
                     KEENTQLAVVDDQVNTGLIEAFKEDYAALNDLQSDYVRDLVIRTFCPLGSTMESEIDRQ
                     AEVRNYNQYLEFYKKSKDDFVKAVKPLIEKILGVKIFFDQYQVKEKGMQPKLLISNISL
                     DMLVKASNLPRLVTYLNTTNDKNEFENTVWFAIVPDVELNQSSGGKLQRVRFAGNQRQE
                     KAGTNTMENLSILMNAIQPYRITTFFSFQTGEETTFNYIATEGIGVFKEKCTPLMKKEY
                     SEFAVPCIPNATIIPKDKSGLILDRKMVMDEDGNVSLSSEKEDVMKMWLEGIYVGAAYE
                     AAGITAAWQCPEYLKERFQNTSKEYPGVRFDVEADDNALLASTSLTKEISGFTNAIKNS
                     INNTGFGFVFSSDNAQHKGKEIKNITVYKARNLLSNGTQFEPIYKTLVVTYIERMLRFY
                     SGDFKQDKILKFFSSNPNSQKSRWDADRQHINSILQDGDELDYTIDEKYGICNVMVTFA
                     NTTRNLKVQLTKKAGEKSGE"
     CDS             8619..9047
                     /locus_tag="ctg131_9"
                     /transl_table=11
                     /translation="MGLRLKIEGSESINLLETSIVKVKFGADIPYDSNARSTDLGSSVL
                     IMGKILASVDGEAADDTSKLARWSLIPAENSDCYRKVQIDVVNASQIVRQITIPNAFVV
                     DYEEDFTDDTGAGTFNLLIKQKKDKMTNLKFEGGFSGE"
     CDS             9102..9530
                     /locus_tag="ctg131_10"
                     /transl_table=11
                     /translation="MGFKLKVEGPSTIELGTTIITGVKFRTDIPHDSNARSTDMGSTVT
                     ITGKILTAVDGDPFDNTRQLGLWALVPAEKSDCYRKVSIEVIAASQVVRKYTYPNAFVV
                     DYREDYGDVEGVGSFTLIIKQKKDKMTQVAVEGGYSVS"
     CDS             9624..10196
                     /locus_tag="ctg131_11"
                     /transl_table=11
                     /translation="MKKNRWIKITADIVILVCSIILWGLIYFGFHAFRQFIFNFYLLAF
                     VLVLSLADFVYQIYSPQIQENARGEKGASGLRAHEINRLILLNEQDKPIKSWDMAGRVS
                     LVIGRAGKEEDVDVDLEDCAFSGFIDFQHAALNFCIEQWYVEDLGSKNGVRIQKADDGE
                     CYKVMGRPCRVEAGDILYIANTRLLLS"
     PFAM_domain     9939..10166
                     /aSDomain="FHA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00498.28"
                     /description="FHA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_11_0007"
                     /evalue="1.60E-07"
                     /label="ctg131_11"
                     /locus_tag="ctg131_11"
                     /protein_end="181"
                     /protein_start="105"
                     /score="31.7"
                     /tool="antismash"
                     /translation="VIGRAGKEEDVDVDLEDCAFSGFIDFQHAALNFCIEQWYVEDLGS
                     KNGVRIQKADDGECYKVMGRPCRVEAGDILY"
     CDS             10249..10746
                     /locus_tag="ctg131_12"
                     /transl_table=11
                     /translation="MSLEKCPKGHVYNAKRYGRICPYCNMKLQEETAATKPVGFEPPVE
                     VLQKEVRPVCGWLVCIEGARVGMDYKIYKGKNFAGRGDDMDIQILGDNEINRKNHTIIV
                     YDDKKLNTMILPGDSSGLAYLNDEPVYVPMELKPYDIISMGNSRFLFISLCGTNFSWDD
                     VK"
     CDS             10761..11642
                     /locus_tag="ctg131_13"
                     /transl_table=11
                     /translation="MGMTGTEMLGVIVLVCLVTAVIVRLLAGFAQKENVLGAYGNQNLQ
                     VDVGIGQTTGNKELQSDRARAERTSAGVLAVIADGIGKRNIGQVCAQIAMDTILDKYEP
                     YTFLSQPDHFFRTAFYEANRRIQMTLEEAKGGASLGTVFVNETKLYYALAGNIQIALFR
                     GGEIIPLSKGQTIAVLAEEAWKDGRLSRQEAVWSMDEKRLWNYVGMDGFCEIEVESQPI
                     LIKPEDMVLLATCGIFEELSWSEIEDILVKQGSLQEKAGEIVRATEQKEGTQKENGSVI
                     LLRVPNGTGAVS"
     PFAM_domain     10962..11303
                     /aSDomain="PP2C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00481.23"
                     /description="Protein phosphatase 2C"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg131_13_0008"
                     /evalue="2.50E-06"
                     /label="ctg131_13"
                     /locus_tag="ctg131_13"
                     /protein_end="181"
                     /protein_start="67"
                     /score="27.4"
                     /tool="antismash"
                     /translation="RTSAGVLAVIADGIGKRNIGQVCAQIAMDTILDKYEPYTFLSQPD
                     HFFRTAFYEANRRIQMTLEEAKGGASLGTVFVNETKLYYALAGNIQIALFRGGEIIPLS
                     KGQTIAVLAE"
     CDS             11657..13315
                     /locus_tag="ctg131_14"
                     /transl_table=11
                     /translation="MRRMNSEFKTVNMSEEGKKLSNRDYFGYVEMDDFACYVLADSLDE
                     DSSANSAKLVVESIIRDFTEMPSMGKGRLKRIVHRAHVELRKQKTGMHLKAAVVIAVTD
                     YQRIRYVYVGNSRYYLIRNARIMERTKDQSLTSNLMEAGKIPLDQAAVHEERNNLYSFL
                     GERGTPEIQISKKRKLENGDIFLLLTRGVWEQCPDESLLEIINDAKEPEEVLQRTEDWI
                     LGKQETTEIDNYTMAVTFARKVYQSPKKTWTPKKILMIAVSIVAVIGGISIALFLHHRN
                     IQTRERKLTETMKDGENYLQNDNYQRAVEEYSEAKKLAGSLKKDKEALQADQYKKLSEQ
                     IILADEALIAGEYEKAQQLYITARKMSQEAGNVGKNYIDSQLDRAKNYMAVYDLIALGE
                     KKEEYGNLEGAIAAYKEAREKAADIYDREGKAEALEKQAAAEEELEKAQLEEKAKKKEQ
                     EEAVAAEAAKQKQEEEAALELENQQKANDQKNAIDLENQGNMLLAEGQYESAITFYQAA
                     QAIYRRLELDELADNLKPKIDAAKAGMNAAAEEKQ"
ORIGIN
        1 aggttgcgag gtcaatgaag caggaagccc attggcttta gacaatgggt agttcacatc
       61 gattatgtca gggtatataa gaagctgcca gagggacaga gaatgttgtc agaggatgag
      121 cttcaggttg tggatatcaa ggcagaaaat ctcatattag aagacactaa tgtagaacta
      181 cggacatatg cggactgtga cagttatagg gaaaagctgc tttctgggac aaaatcttat
      241 gtaaggattt actggaatga tggcgtagag actcaggagc ctgtacagtg ggaaaaaatc
      301 acagaggaag atttagcgca gattcacagc ggaaaaacaa taacaaaggt tggatacgtg
      361 ccgtccatac agcagaatgt aacaatgaag attggtccaa gagcatattc gatggaaaac
      421 ctcagtggtg taagaggaat gaaagacctg gattatgtgt ttgacggact gatcaatgaa
      481 gctgccggaa ctccaagtgg tgagtttaag ggttttgatt tttcgaacaa cagagcttct
      541 attatatacg attttcagga aacagtgaac ctgaaaggaa tggacatttg gtgcaattat
      601 ggaaatgatc agggaattaa gaaaatgaag gttgctgtat gggatgagga gcaggagaga
      661 tgggtaatat tgaaggatga agatggaact gagcaggaat ttattatgaa ctggcagacc
      721 gcagtacagg tagcagaaaa gcagagcata gcctttcctg gagttgacac aaagaaggta
      781 aaaatcatta ttctggatgc tggatataaa tggaataaat tctctattcg tgagattgaa
      841 tttcaaagct gatttttgga tttaaacaaa aatatagata agctgtgcat aaatgggaaa
      901 aagcactgga ttttctgcag gaggctgagg aatttattgc aattttggat gatttttcaa
      961 aaaattgata aaaagacttg acacaaaagg ttctccacta ttataatctt aatagtgcta
     1021 aaaatacccg tacagttgta taggcacaat ccacaactgg agggaggtaa ggtgtgagac
     1081 tatgtcaaat gttatcgtaa aagagaacga aactttagat agtgcactcc gcagattcaa
     1141 gagaaactgc gcgaaggcag gtatccagca ggagattcgt aaaagagagc attatgagaa
     1201 gccaagtgta agacgtaaaa agaaatcaga ggctgctcgt aagcgtaagt tctaatcaga
     1261 atattaaaat gtggactgtt gcagattttg caacagtcct ttttcgctgt atagggaata
     1321 ccgatttcct atagaaccta aaatggttat atttttgtgt ctatacaaaa agaaccaaaa
     1381 atagttatag tattgatgaa gagagagaaa acgaatagat gtatggaaaa gatacagtta
     1441 ttgggatatg tgatgataat ccagaagatg tgattcgaat tcaacaggaa atttgtaatt
     1501 gtttgaagct gctaggagaa gaaaatccaa tcataatcgt ttatgaaagc ggtagagagc
     1561 tgttggaaaa ttgcaaaaag cagacaatag atttggtgtt tttggatttg gagatgccag
     1621 agtgtaatgg ctttgaactg gcagaacaga tatatgattt taaccaggca ataaaaatta
     1681 tttttgtttc caatcatgaa aatatggtat ttgattctta tgaatatgca ccattatggt
     1741 ttgttaggaa aagttttatg gaacgtgata tgttaaaagc gattcaaaaa tatctccaga
     1801 tggaaacaaa agttcaaata tggtgtaaga gcggagaagg aacaaaggac atatggctat
     1861 atataaataa agtattatat atagaatgta gtggtcatac cctctccata catatgaaaa
     1921 ataaggagtg ccataaaatc tatggttctt taaagtcatt agaagaaaaa ttgcatacat
     1981 atggttttgt tcgcattcat aaaaattttc tggtaaatgc aagatgcgta aaagaaattg
     2041 gaaatcgcac tgtctgtttg ccagatggaa tagaattaga tattggcaaa aatagaagaa
     2101 aagaaattaa acagttatta gaaaattaca acggaggaag gaggatgtgt taaaattaca
     2161 gattatttga ttaacggatt gtcgtcagtg attgcgttag agtatatcag ccatggattg
     2221 aaacaaaagt atagaggcta tcgcggtacg gtattgtttt tggcgggctg taccgcatat
     2281 ttttttgtgg ttacaggatt aaatcattat accaattttg aaggggtgct aggcattggt
     2341 tatggtgttg ttttatatgt gtattgtctt ttggcagcgc agggaaagaa atcagatttc
     2401 tttttgttaa gtgttgtttg ggtgttgctg gcatttatta gtgcatatgt aatgtttgcc
     2461 ttatggggca tattttcagg aggaagtctg gaagagcttt taaaaacaga gagtcaggcg
     2521 catatgtatt tttcactgtc agcaggggct ctgcggtttt ctcttggaag aatagtattg
     2581 gcggtttatc ggaggagaaa acaaaaaaag ttgttggcag aagactggat gatggcacta
     2641 atttttttta tatttttctt tttgatactg tttatgtttc gcttggaacg gggtggatta
     2701 gaccaaaaag aacggtataa tttgtcttta tggatcttat tgggaatctt tttggtaatt
     2761 cttctactag gcggattcta tcaattaata ggaaaatata gaatagaaaa aatagcagag
     2821 gaataccgga aagaaaacca gaagttgcag gaggaacaaa ttcataattt gtaccagctc
     2881 ggacgtgagg caaatcgcct gagacatgat atgggtgcaa aggtaaatgt cgtttatgag
     2941 caattaagaa aaaaagatta ccaggaagca gaagaaaatt taaaaaggat aggagatgag
     3001 tgggaagatt atctggaaat tccggaggag acaggaaatg aaggattaaa tgcagctttg
     3061 ataagggcaa ttcatgaatg cagaggaaaa gatattcgat ttcattatgc ggtattagga
     3121 agtgtaagcg gagttgacag tttggatatg ggaaatctga tacataatct tttgaagaat
     3181 ggaattgagg cctgtgataa ggtgcagggg aaacgcgagc ttgagattgt aatcagacgt
     3241 gacggattta tggtagaaat cgaaattgat aacacaattc aggattctgt catggattgg
     3301 aatccttcat ttaaaacatc aaagatagaa aaggaaaaac atggctttgg aatggagaca
     3361 atccgaagga tagtagagta ttatgatgga gattacattg cgtgggagga aggagagagg
     3421 ttacttcaaa gaattacact taaaatagag aaatagaaga ataaggagat ggcatatatg
     3481 atgtatatgc catctccttt tttctacaaa aaattaccga ttatgctgaa aaattactga
     3541 taatgataaa ccagttgttt ttgaaaacta aatttgtaat aatgaactaa aaattgaagc
     3601 taaatctgta atcatgaatc aaaagaaaga aatagtatca tgttggagag aatttctatt
     3661 tatttatcaa cattattatt gcaagaaaag attatcactg tagatgaaaa agacacttat
     3721 aaatatgggc ttgaaataac aatggcaaac ataataaacg gatttatagt gctcattata
     3781 ggtgttgtat taaatctctt agtagaatct attttgtttt atctggtatt tgtgagtttg
     3841 agattctttt gtgggggata tcatgcagat agttatacaa aatgtttttt ttcgtttgcg
     3901 tttacaacta tagtatgcct ggtcatttct gagaggttag cacagtatga agaaataata
     3961 cagggtctat tctttataac ggcagtaatg ttaggggaac atattttgaa aatggctccg
     4021 atagaacatg aaaatcggcc actaacagag gaagaaaaaa atttatttag aaagcgaagt
     4081 gtgcaagttc tcgttttttg gattgcaata ggaatcatct tatggatggg ccatttggtg
     4141 cagatggaga ccagtctaat aagtgcattc atagcagtaa caattttaat gagaatagga
     4201 ggaattggtt attatgaaaa gagaagtgct tcaggtgttg gcaaaagtag ctaatagtgc
     4261 tgcgaagaga gcagatggca gagcttctga gtttggaatg catcagccga agagaccaaa
     4321 gaaaatcaaa aaatagtgca tgattgggag ggcagaaaaa atgaaaaaat atgggatggt
     4381 atgtatactg tgtctatttt ttatactttt ctgcccttgg tctgttcgtg cagaggaatt
     4441 tatcagcaca aaaaacggac tggatgtcat gtttgttatg gattacagcg ggtccatgaa
     4501 aaccaatgat tcgcaggata ttgcaagggg aatggtgaag gcatttgtag atactgtaca
     4561 cagcgcggat atccgtgtgg gctttgtggc atacaatgac cgtattctta cgtctacatc
     4621 cccgcttacg atacagacta cggaggagag agcgcagtta aaagaactga tcggtcagga
     4681 acagtatgca ggcaatacag atattggact tggattgtca tatggttacg aattgctggg
     4741 agagccatct ggaagaaagc aggtaatcgt cttaatttca gacggcgagg cagatttaaa
     4801 ggggtctgat acgggaagga gcacagagat atccagacag gatatgagat ctgttgcaca
     4861 gaaatgtgca aagacgggaa caaagatata tacaatagtc tttggtgatt atgatgggaa
     4921 tacggaagct ctgaaagaaa tttcaaaaaa tacactggca cagatgtatg cggcagaaac
     4981 accggaaagc ctcattgaag tgttatatgg aatttttggc acaaacatgg attacagtat
     5041 tcaggagatt gccgacagcc tgtttgcgcc tgggattcaa aatatcagaa taagcttaga
     5101 agaaaattat ctggatgaaa tggatgtgct gttgatttcc ccgagaaaga ttggggatgt
     5161 gggcattttg tatggggatc gggagattga aacgattaac ctcggaaatt atgcggtagg
     5221 aaagattaca gacattgaca gcagtatcag ggaacttacg ttgcaggcgg aaactttgga
     5281 gaatcaaaaa cttcaaatat atttattcag ctaccgttca ctgacgcctg ttctggaact
     5341 tgataccact gtatgtaaga atgagccgct ttcgtataaa ctgtattttc gcgataaaag
     5401 tggaaataca gtatctgatg aaaagcttta cgaaaatttt atttatgagt tttccataaa
     5461 tgatggagaa aagaaagata cgccggaacg ttttttgaat atagaacctt ccaacggata
     5521 tatgcagggg caggcgatca tggagcagtc cgggacgtgg ttttttcagg catatatgga
     5581 agacagcatg ggaaacagtt cctttaagcc aatccctgtt gtggtggaaa atcgcaaacc
     5641 aaacggggca ctgccggcgg atgaaggatt tacggtgctc acccgggaac agttctatct
     5701 gctggacgag tattttacgg atccggatgg ggatcagctg tcatatttat tgaaaacaga
     5761 tcccggaaaa tatctggata tagagcttgt caataatgtc ttaacaatcc accccttaaa
     5821 atcggggacg cagacgatat tactggaagt ttcggatggt gaaagcactt atacctatga
     5881 acatgaaata gaaattatgc cgctttggaa ggtatatggc tgggtatttg ttcttctggc
     5941 aggaggagtc ataggggctg tgatctggaa aataatgcac aaatctaagc ccgatttgga
     6001 acgtctgaca aaggagacaa agaaaaatca tttttgtggc aggatgaatg cctattttac
     6061 tgcacagccg gatgcagaga aggagattcc accattgtca tttgaacttt ataaggtcag
     6121 ggaaaataga ctggcactgg gagcacttct ggaaggatat ccggatgcag tacgtgcaat
     6181 ggaattgaac gaaatacatc tgatggcaga tgaagacaga cgaatgattt tatatcacac
     6241 atcaaaaagt gttatcatga tcgggaattc catcgcgtgt aagcagatac agtatagcgt
     6301 tggtttcggg gatgtaattt atatcatgcc ccaggacggg agctatgagc tggaaataca
     6361 ttacattgcg atgatccaat aaagaccaaa gaataggagg acgtgagaat ccatggaaac
     6421 aatcacacaa accaaccgga ctctgttgtt cgcggaaatc aatccggaac gggaaaacat
     6481 tcttaccctg attggggatg taaggggaaa gaacagtctg gatgacgaca agatgaaaga
     6541 gatcaatgag gagctgcttg tatccagttt tgatgagttt cttgaaaaaa tgagtccagt
     6601 tgtttattcc tattgtgatg cgaatacagg cgagatgaaa tacagtcttg tacgcccgga
     6661 gaacattcct gataactgca tcacagaaat tccattgaat gagaataatg acttgctgaa
     6721 tatgctgatc actcttttgg aagccaagag cgcacaggga gttgcgaatg tggattttac
     6781 gtttagtaat gtgttggata tgatttctcc taaaaagatc atggaggata tccgtcaggt
     6841 ccggagagag atccagtata cctatgaaaa atatgtacag ctggatgacg aggatcccaa
     6901 aaagttggat ttaggtgacc gtttgaacga tcagtttgaa caggcaagcc agaattacaa
     6961 tcatgtactt gcgatgctcc cgcttgcaat agaggatgcc aaaacgcgtc tgctgttagg
     7021 cgatggagaa acgaagcagg gaagtcagga gtttaaggcc ggattgctga gcatgggtga
     7081 agatggcgag ctcaagattc tggagatgca aaaggaggag aatacccagc ttgcagttgt
     7141 tgacgatcag gtcaacacgg gtctgatcga ggcattcaaa gaggattatg ctgcattaaa
     7201 tgatttgcag tcagattatg tgcgtgatct ggtcatccgt acgttctgtc cattaggttc
     7261 tacgatggag agcgagatag atcggcaggc agaggtgcgc aattataacc agtatcttga
     7321 gttttacaag aagagtaagg acgactttgt aaaggccgta aaacctttga ttgaaaaaat
     7381 tttgggcgta aaaattttct ttgaccagta tcaggtaaaa gaaaaaggga tgcagccgaa
     7441 gcttttgatc agtaatattt ccctggatat gctggtaaag gcaagcaacc ttccgaggct
     7501 cgtaacttac ttgaatacaa caaatgataa aaatgagttt gaaaacacgg tgtggtttgc
     7561 cattgtaccg gatgtggagt taaaccagag cagcggcggc aaattacaga gagtccgctt
     7621 tgcagggaac cagaggcagg agaaggcagg aacaaatacg atggagaact tgtcaatcct
     7681 gatgaatgcc atccagccgt accggatcac gacatttttc agtttccaga caggggagga
     7741 aaccaccttt aattatattg caacagaagg aatcggggta tttaaggaaa aatgtacgcc
     7801 tttgatgaaa aaggaataca gtgaatttgc ggttccatgc attccaaatg caacgattat
     7861 tccgaaggat aagtcaggac tgatccttga caggaaaatg gtgatggacg aggacggcaa
     7921 tgtttcgctt tccagtgaaa aagaagacgt catgaaaatg tggctggaag ggatctatgt
     7981 aggagcggcc tatgaggcgg caggaattac ggctgcatgg cagtgcccag agtacttaaa
     8041 agaacggttc caaaatacaa gcaaagaata tccgggagtg agatttgacg tagaggcgga
     8101 tgacaatgct cttttggcat ccacgagtct gacaaaagaa atatccggtt ttaccaatgc
     8161 cattaagaac tctattaaca acacgggatt cggctttgta ttttcatcgg ataatgcaca
     8221 gcacaagggg aaagaaatta agaatattac ggtgtataag gcacggaacc tgcttagcaa
     8281 cggcacacag tttgagccta tttataagac gctggtagtt acctatattg agaggatgct
     8341 ccgtttttac agtggtgatt ttaaacagga taagatattg aaatttttca gcagtaatcc
     8401 aaatagtcag aagagccgct gggatgcaga ccggcaacat atcaactcaa ttcttcagga
     8461 tggcgacgaa ttagattata ccattgatga gaagtatgga atctgcaatg ttatggtgac
     8521 ctttgcaaat actaccagga acttaaaggt gcagcttacc aaaaaagccg gagaaaagtc
     8581 gggagagtaa gtaaaaagga ttaaaaggag gaaaaaggat gggattacgt ttgaaaattg
     8641 aagggagcga gtcaatcaac cttctggaga ccagcattgt aaaggtaaaa tttggggcag
     8701 atatccccta tgacagcaat gcgcgttcca cggatcttgg ctcaagtgtt ttaatcatgg
     8761 gaaagatact ggcttccgta gatggagaag ctgcggatga caccagcaag ctggcaagat
     8821 ggtcgctgat tccggcagag aattccgact gttaccgaaa agtccagatt gacgtggtaa
     8881 atgcctctca gatcgttcgc cagattacga tcccgaatgc gtttgtggta gattacgaag
     8941 aggattttac ggatgatacg ggcgccggaa catttaatct ccttatcaag cagaaaaagg
     9001 acaagatgac aaatctgaaa ttcgagggcg gattcagcgg agagtaagca ggaaactgtg
     9061 cagtttgaaa tttaacagtg gcatagcagg aaggagacat tatgggattt aaattaaagg
     9121 tggaaggacc atcaacgatt gaattaggaa ctacgattat taccggcgta aagtttcgca
     9181 cggatattcc ccatgacagc aatgcacgtt cgacagatat gggaagcacg gtgacgatca
     9241 ccggaaaaat cttaactgcc gttgacggag atccgtttga caacaccaga cagttggggc
     9301 tttgggcgtt agttccggca gaaaaatctg actgttacag aaaggtgagc atagaggtga
     9361 ttgcggcatc tcaggttgta cggaagtata catatccaaa tgcttttgtt gttgattata
     9421 gggaagatta tggagatgtg gaaggtgttg gaagctttac acttatcatt aagcagaaga
     9481 aagacaagat gacgcaggtt gctgtagaag gcgggtacag cgtatcataa gaggctttcc
     9541 gcaagcgatt aaaaaaagca tgaaaagagc tgcctgttta ccgggcagct ttttttgaaa
     9601 ggaaaaagag gaggaagaaa gggatgaaaa agaaccgttg gataaagatt acagcagata
     9661 ttgtaatcct ggtgtgcagc attatcttat gggggctgat atattttgga ttccatgctt
     9721 tcaggcagtt tatattcaat ttttatctat tggcttttgt tttagtcctt tcattggccg
     9781 attttgttta tcaaatatat agcccccaaa tacaggagaa tgcccgaggg gaaaaggggg
     9841 cttcaggact aagggcacat gaaattaatc ggttaatttt attaaatgaa caagataaac
     9901 cgataaaatc atgggatatg gcggggcgag tttctctggt gattggcaga gcaggcaaag
     9961 aagaagatgt agatgtagat ttggaggatt gtgcttttag cggatttata gattttcaac
    10021 atgcagccct taatttctgc atagagcaat ggtatgtaga agacctgggg tctaaaaatg
    10081 gtgtcaggat acagaaagca gatgatggag aatgctataa ggtaatgggg cgtccctgca
    10141 gagtggaggc aggggatatc ctctacattg caaataccag gcttctttta tcctgattca
    10201 aaagggctga aattgtcata aaactaaagg atagggagag agaaacagat gagtttggaa
    10261 aaatgcccaa agggacacgt atataacgca aaacgttatg gaaggatatg tccttactgt
    10321 aacatgaagc ttcaggaaga aacagcagcg acaaaaccag tcggttttga gcctccagtg
    10381 gaggtgctcc agaaggaggt tcggccagta tgcggctggc tggtctgcat tgagggggcc
    10441 agagttggaa tggactataa gatatacaaa gggaaaaact ttgcaggaag aggagatgat
    10501 atggatattc agattttagg agataatgag ataaacagaa agaatcatac aattatcgtg
    10561 tatgacgata aaaagctgaa tacgatgatt ctgcctggtg attcctctgg acttgcttat
    10621 ttaaatgatg agccggtata tgttcctatg gaattaaaac cttatgacat aataagcatg
    10681 ggaaacagtc gatttttatt tatttcattg tgtggaacaa atttttcatg ggatgatgtg
    10741 aaataagaaa ggatcaaaac atgggtatga cagggacaga aatgttgggc gtgattgttc
    10801 tggtatgtct ggtgacggca gtgattgttc ggcttttggc cggatttgca cagaaggaaa
    10861 atgtgttagg agcttatgga aatcaaaatc tgcaggttga tgtcggaatt ggacagacaa
    10921 caggaaataa agaactccag tctgacagag cacgggcaga gagaacttcg gcaggtgttt
    10981 tggctgtaat tgcagacgga atcggaaaaa gaaatatagg acaagtgtgt gcacagattg
    11041 caatggatac cattttggat aaatatgagc cgtatacttt tctaagtcag ccagaccatt
    11101 ttttccgcac agcattttat gaggcaaatc gaaggattca gatgacatta gaggaagcta
    11161 agggcggagc aagccttgga acagtattcg taaacgagac aaagctgtac tatgcacttg
    11221 ccgggaatat acagattgcg ttatttcgcg gaggcgagat cattccttta agcaaagggc
    11281 agacgatagc tgttttggca gaggaagcat ggaaagacgg aaggctctcc cggcaggaag
    11341 cagtatggag catggatgaa aaaaggctgt ggaattatgt aggaatggat ggcttttgtg
    11401 aaattgaagt cgagagccag ccaattttaa taaaaccgga agatatggtg ctattggcaa
    11461 cctgcggaat ttttgaagaa ttatcatgga gtgagataga ggatattttg gtgaaacaag
    11521 ggagtcttca agaaaaggca ggagagattg ttcgggcaac tgaacagaaa gagggaactc
    11581 agaaagaaaa cggaagtgta atcctgttgc gggttccgaa cggtaccgga gcagttagtt
    11641 agcgtggagg aatggcatga gaagaatgaa ttcggaattt aaaaccgtca atatgtcaga
    11701 ggaagggaaa aaattatcca atcgagatta ctttggctat gtggaaatgg atgattttgc
    11761 ttgttatgtt ctggcagata gtcttgatga agattcctct gccaatagtg ccaaacttgt
    11821 ggtggaaagt attatccggg attttacaga aatgccgtct atgggaaagg ggcggttaaa
    11881 acggatagtg caccgggcac atgtggagct tcggaaacag aaaacaggaa tgcatctaaa
    11941 agcggctgtc gttattgcag tcaccgatta ccagaggatt cgatatgttt atgtgggaaa
    12001 cagccgttat tatctgattc gcaatgccag aatcatggag aggacaaagg atcagtccct
    12061 gacaagcaat ttgatggaag ctggtaagat accgcttgat caggctgccg ttcatgagga
    12121 acgcaacaat ctgtattcct ttttaggaga gagagggact cccgaaattc agatatcgaa
    12181 aaaaagaaaa ctggaaaatg gcgatatttt cttattgctt acaagaggtg tgtgggaaca
    12241 gtgcccggat gaaagtctcc tggaaattat taatgatgca aaagagccgg aggaggtgct
    12301 tcagcgtacc gaagactgga ttttggggaa acaggaaaca acagaaattg ataattatac
    12361 tatggcagtc acttttgcca gaaaggtata ccagtcccca aaaaaaacgt ggacaccaaa
    12421 gaagatacta atgatagcag tttctattgt ggctgttatc ggagggatta gtattgcctt
    12481 gtttcttcat cacagaaaca tacagaccag agagcggaaa ctgacagaaa ctatgaaaga
    12541 tggagagaac tatcttcaga atgataatta tcagagagca gtagaggaat atagtgaagc
    12601 aaagaagctg gctggcagtt tgaaaaaaga taaggaagcc ctgcaggcgg atcaatataa
    12661 aaagctgtca gagcagatta ttctggcaga cgaggctctc atagccgggg agtatgaaaa
    12721 agcacaacag ctatacatca ctgcaagaaa aatgtcacag gaggcgggaa atgtagggaa
    12781 aaattatatt gacagccaac tggacagggc gaagaattat atggctgtat atgatctgat
    12841 tgcattaggg gagaaaaaag aagagtatgg aaatctggaa ggtgcaattg ctgcttataa
    12901 agaagcgaga gagaaggcag cagatattta tgacagagaa ggaaaagcag aggccttaga
    12961 aaagcaggct gctgcagagg aagaattgga aaaagcacag ctggaagaaa aagcgaagaa
    13021 aaaagagcag gaagaagccg tagcggctga agcggcgaag caaaaacaag aggaagaggc
    13081 agctcttgaa ctggaaaatc aacagaaagc caatgaccag aaaaatgcaa tagatcttga
    13141 aaatcagggg aatatgcttt tagctgaggg acagtatgag agtgctatta ctttttatca
    13201 ggctgcacag gcaatttaca gacgactgga acttgatgaa ttggcagata acctaaaacc
    13261 caaaattgat gcagcaaagg caggaatgaa tgcggctgca gaagaaaagc aataacttaa
    13321 ggaaaagcga ggaacgatac ttatgacccg atatacatat acattaaacg caaatcgtga
    13381 ggcaactccc acaaattcct ataaaaggaa tgaacttgag aagatgacga tgttccatct
    13441 tagagaaatt tgcagaaaag aacggctggt agtgtcgtct gcccaacgag aggatagaga
    13501 gagcttaatt catctcatca tgcgtttccg ggggcaaaag gaatatcgtc acattcaggc
    13561 tcaatgtgaa ggcggtttgg aacggattca ggagtatctt caatctcatg gcgttttgct
    13621 tacagaccat gttgatattc gggtgccagg cactatgacg ttatatagag gaacgcagat
    13681 aaatgagttg gatggatatc agatacagtc agggcaggat atctacgaag ggaatctttt
    13741 gctggtagat gaatcatttc aggtctatac ctgcttttat gtccagagaa tacaaagaaa
    13801 ggcttatatc tttaagggaa aggatgttca ggtccgtcca ttagaaaaac atcagtattt
    13861 tattctgtat ttgctaaaag aacgggattc agaattttta tatgactgct actatgggaa
    13921 ccggactctg gctcccggaa ttttagaagg ggtgagaatt cctcttttag atatccagga
    13981 aaaagagatt gcacaagcag aactcccact tattatcgat cttggaagtt cgaatactac
    14041 aatggggatt tgcctgccag atggaagcat acagacagcg atagtaaaag ggagcgaaat
    14101 tattccaagc cttgttggag tgtgccggca ggaaggagaa gagaccacat ttgtatttgg
    14161 acaagatgca aaggcactgg gagaggaaaa ttacaggaat gaggatgtga ctatttttta
    14221 tgacatcaaa cgttggatta gtgatccaac gcggctggag ggggtcattc ttacagatgg
    14281 atataaatat catttttcca gaaaggaaat gctgcgcgct tatttggaat atttgc
//
