Select genomic region:
Overview
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### Identified secondary metabolite regions using strictness 'relaxed'

NC_016627.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 21,902 | 40,856 |
Region 2 | cyclic-lactone-autoinducer | 876,102 | 895,712 | geobacillin I | RiPP:Lanthipeptide | 20%
Region 3 | other | 975,218 | 1,016,360 | thailanstatin A | NRP + Polyketide | 10%
Region 4 | T1PKS | 2,110,287 | 2,158,512 |
Region 5 | RRE-containing | 2,386,848 | 2,404,876 |
Region 6 | ranthipeptide | 2,431,280 | 2,452,626 | dipeptide aldehydes | NRP | 11%
Region 7 | transAT-PKS,NRPS,NRPS-like | 3,057,559 | 3,132,222 |
Region 8 | RiPP-like | 3,980,555 | 3,992,780 |
Region 9 | cyclic-lactone-autoinducer | 4,172,041 | 4,192,579 |
Region 10 | cyclic-lactone-autoinducer | 4,735,732 | 4,753,914 |
Region 11 | cyclic-lactone-autoinducer | 4,869,612 | 4,890,256 |

NC_016627.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 21,902 - 40,856 nt. (total: 18,955 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

No matches found.

No matches found.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 876,102 - 895,712 nt. (total: 19,611 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.1 |  | 0.18 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000616.1 |  | 0.17 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  | 0.17 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000506.1 |  | 0.16 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000550.1 |  | 0.16 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0001743.1 |  | 0.16 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.16 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000538.1 |  | 0.16 | RiPP | nisin Z | Lactococcus lactis
BGC0000504.1 |  | 0.16 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000528.1 |  | 0.49 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000616.1 |  | 0.48 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000486.1 |  | 0.48 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0000506.1 |  | 0.47 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000550.1 |  | 0.47 | RiPP | salivaricin G32 | Streptococcus salivarius
BGC0001743.1 |  | 0.46 | RiPP | plantaricyclin | Lactobacillus plantarum
BGC0001222.1 |  | 0.46 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.46 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000538.1 |  | 0.46 | RiPP | nisin Z | Lactococcus lactis
BGC0000504.1 |  | 0.46 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 3 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 975,218 - 1,016,360 nt. (total: 41,143 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or fom1 or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001863.1 |  | 0.21 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.20 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001862.1 |  | 0.20 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.20 | RiPP | pallidocin | Aeribacillus pallidus
BGC0000626.1 |  | 0.19 | RiPP | thuricin | Bacillus thuringiensis
BGC0001407.1 |  | 0.19 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0001210.1 |  | 0.19 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000539.1 |  | 0.19 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000504.1 |  | 0.19 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001863.1 |  | 0.53 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0001861.1 |  | 0.53 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0001862.1 |  | 0.53 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.53 | RiPP | pallidocin | Aeribacillus pallidus
BGC0000626.1 |  | 0.52 | RiPP | thuricin | Bacillus thuringiensis
BGC0001407.1 |  | 0.52 | RiPP | bicereucin | Bacillus cereus SJ1
BGC0001210.1 |  | 0.51 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000539.1 |  | 0.51 | RiPP | nukacin ISK-1 | Staphylococcus warneri
BGC0000504.1 |  | 0.51 | RiPP | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 4 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,110,287 - 2,158,512 nt. (total: 48,226 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001161.1 |  | 0.22 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001163.1 |  | 0.22 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001162.1 |  | 0.22 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0000044.1 |  | 0.21 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0000427.1 |  | 0.20 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001276.1 |  | 0.17 | Polyketide | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001615.1 |  | 0.17 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001641.1 |  | 0.17 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.17 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.17 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001161.1 |  | 0.55 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001163.1 |  | 0.55 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001162.1 |  | 0.55 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0000044.1 |  | 0.53 | Polyketide | dawenol | Stigmatella aurantiaca DW4/3-1
BGC0000427.1 |  | 0.52 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001276.1 |  | 0.49 | Polyketide | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001615.1 |  | 0.48 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001641.1 |  | 0.48 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.48 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.48 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 5 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,386,848 - 2,404,876 nt. (total: 18,029 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.20 | RiPP | siamycin | Streptomyces nodosus
BGC0000554.1 |  | 0.16 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000486.1 |  | 0.16 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.1 |  | 0.16 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.15 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000584.1 |  | 0.15 | RiPP | colicin V | Escherichia coli
BGC0000575.1 |  | 0.15 | RiPP | lariatin | Rhodococcus jostii
BGC0001356.1 |  | 0.14 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001645.1 |  | 0.14 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001889.1 |  | 0.14 | RiPP | fusilassin | Thermobifida fusca YX

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001779.1 |  | 0.52 | RiPP | siamycin | Streptomyces nodosus
BGC0000554.1 |  | 0.46 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000486.1 |  | 0.46 | RiPP | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.1 |  | 0.46 | RiPP | acidocin B | Lactobacillus acidophilus
BGC0000491.1 |  | 0.46 | RiPP | gassericin A | Lactobacillus gasseri
BGC0000584.1 |  | 0.45 | RiPP | colicin V | Escherichia coli
BGC0000575.1 |  | 0.45 | RiPP | lariatin | Rhodococcus jostii
BGC0001356.1 |  | 0.43 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0001645.1 |  | 0.43 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001889.1 |  | 0.43 | RiPP | fusilassin | Thermobifida fusca YX

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 6 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,431,280 - 2,452,626 nt. (total: 21,347 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001554.1 |  | 0.18 | Other | coenzyme F430 | Methanosarcina barkeri str. Fusaro
BGC0000599.1 |  | 0.15 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001575.1 |  | 0.09 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0001940.1 |  | 0.06 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000975.1 |  | 0.05 | NRP, Polyketide | cryptophycin-327 | Nostoc sp. ATCC 53789
BGC0001104.1 |  | 0.05 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001554.1 |  | 0.50 | Other | coenzyme F430 | Methanosarcina barkeri str. Fusaro
BGC0000599.1 |  | 0.45 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001575.1 |  | 0.34 | NRP | dipeptide aldehydes | Ruminococcus sp. 5_1_39BFAA
BGC0001940.1 |  | 0.25 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0000975.1 |  | 0.24 | NRP, Polyketide | cryptophycin-327 | Nostoc sp. ATCC 53789
BGC0001104.1 |  | 0.22 | NRP, Polyketide | myxovirescin A1 | Myxococcus xanthus DK 1622

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 7 - NRPS,NRPS-like,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,057,559 - 3,132,222 nt. (total: 74,664 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001023.1 |  |  |  | 0.86 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0000402.1 |  |  |  | 0.76 | NRP | paenilarvins | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001891.1 |  |  |  | 0.73 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000041.1 |  |  |  | 0.64 | Polyketide | oronofacic acid | Pseudomonas syringae
BGC0001276.1 |  |  |  | 0.63 | Polyketide | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001275.1 |  |  |  | 0.63 | Polyketide | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.1 |  |  |  | 0.63 | Polyketide | (-)-Mellein | Parastagonospora nodorum
BGC0000389.1 |  |  |  | 0.62 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001748.1 |  |  |  | 0.60 | NRP, Polyketide | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0001162.1 |  |  |  | 0.59 | Polyketide | 1-heptadecene | Moorea producens JHB

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.69 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001023.1 |  | 0.68 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca
BGC0000402.1 |  | 0.65 | NRP | paenilarvins | Paenibacillus larvae subsp. larvae DSM 25430
BGC0000389.1 |  | 0.65 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001748.1 |  | 0.64 | NRP, Polyketide | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0000426.1 |  | 0.61 | NRP | sevadicin | Paenibacillus larvae
BGC0001050.1 |  | 0.60 | NRP, Polyketide | thalassospiramide A | Tistrella bauzanensis
BGC0000396.1 |  | 0.60 | NRP | nodularin | Nostoc sp. 73.1
BGC0000901.1 |  | 0.59 | Other | ferrichrome | Aspergillus niger
BGC0001873.1 |  | 0.58 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 3057558 - 3132222:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal) + (ohmal) + (D-ser - X) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 3057558 - 3129655:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal) + (ohmal) + (D-ser - X) + (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 3089672 - 3132222:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal) + (ohmal)
Non-colinear ordering:
  ctg1_2666 + ctg1_2668 + ctg1_2669 + ctg1_2665

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2664: ser - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (273..676): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1793..2185): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAdqIGSVgK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      70% (weak)
ctg1_2669: mal
  PKS_AT (6..291): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 75.0%
    inactive: 70.8%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 91.8
    inactive: 48.5
    Methoxymalonyl-CoA: 27.2
    Methylmalonyl-CoA: 17.9
    Propionyl-CoA: 9.6
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_2670: pk
  CAL_domain (156..472): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 160.6
    NH2: 9.4
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0

NC_016627.1 - Region 8 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,980,555 - 3,992,780 nt. (total: 12,226 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.36 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000558.1 |  | 0.24 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.22 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.22 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.21 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.21 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001861.1 |  | 0.21 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000484.1 |  | 0.20 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000617.1 |  | 0.20 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.19 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.69 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000558.1 |  | 0.57 | RiPP | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.1 |  | 0.55 | RiPP | geocillicin | Aeribacillus pallidus
BGC0001930.1 |  | 0.55 | RiPP | pallidocin | Aeribacillus pallidus
BGC0001863.1 |  | 0.54 | RiPP, Terpene | bacillicn CER074 | Bacillus mycoides
BGC0000554.1 |  | 0.54 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001861.1 |  | 0.53 | RiPP | bacillicin BAG2O | Bacillus cereus BAG2O-1
BGC0000484.1 |  | 0.53 | RiPP | glycocin F | Lactobacillus plantarum
BGC0000617.1 |  | 0.52 | RiPP | coagulin | Bacillus coagulans
BGC0000500.1 |  | 0.51 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 9 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,172,041 - 4,192,579 nt. (total: 20,539 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.23 | RiPP | circularin A | Clostridium beijerinckii
BGC0000616.1 |  | 0.17 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000601.1 |  | 0.17 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000503.1 |  | 0.17 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0001579.1 |  | 0.17 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000599.1 |  | 0.17 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000548.1 |  | 0.17 | RiPP | salivaricin A | Streptococcus salivarius
BGC0001660.1 |  | 0.17 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000517.1 |  | 0.17 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.1 |  | 0.17 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000488.1 |  | 0.56 | RiPP | circularin A | Clostridium beijerinckii
BGC0000616.1 |  | 0.48 | RiPP | amylocyclicin | Bacillus velezensis FZB42
BGC0000601.1 |  | 0.48 | RiPP | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000503.1 |  | 0.48 | RiPP | cinnamycin | Streptomyces cinnamoneus
BGC0001579.1 |  | 0.48 | RiPP | duramycin | Streptomyces cinnamoneus
BGC0000599.1 |  | 0.48 | RiPP | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000548.1 |  | 0.48 | RiPP | salivaricin A | Streptococcus salivarius
BGC0001660.1 |  | 0.48 | RiPP | mathermycin | Marinactinospora thermotolerans
BGC0000517.1 |  | 0.48 | RiPP | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.1 |  | 0.47 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 10 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,735,732 - 4,753,914 nt. (total: 18,183 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.36 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000892.1 |  | 0.21 | Other | caryoynencin | Burkholderia gladioli BSR3

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.69 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000892.1 |  | 0.53 | Other | caryoynencin | Burkholderia gladioli BSR3

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_016627.1 - Region 11 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,869,612 - 4,890,256 nt. (total: 20,645 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

No matches found.

No matches found.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names