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Overview
1.1
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1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
1.13
1.14

### Identified secondary metabolite regions using strictness 'relaxed'

NC_002516.2

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NRPS-like,betalactone | 1,302,696 | 1,343,373 | pyoverdin | NRP | 2%
Region 2 | hserlactone | 1,549,883 | 1,569,709 |
Region 3 | phenazine | 2,061,278 | 2,080,664 | endophenazine A / endophenazine B | Other:Phenazine | 38%
Region 4 | thiopeptide | 2,083,444 | 2,116,447 | oxalomycin B | NRP + Polyketide | 6%
Region 5 | redox-cofactor | 2,162,913 | 2,185,057 | lankacidin C | NRP + Polyketide | 13%
Region 6 | NRPS | 2,513,179 | 2,564,072 | L-2-amino-4-methoxy-trans-3-butenoic acid | NRP | 100%
Region 7 | NRPS | 2,638,928 | 2,739,716 | pyoverdin | NRP | 24%
Region 8 | RiPP-like | 3,671,227 | 3,681,461 |
Region 9 | NRPS | 3,710,749 | 3,757,593 |
Region 10 | NAGGN | 3,860,897 | 3,875,657 |
Region 11 | hserlactone | 3,879,139 | 3,899,744 |
Region 12 | NRPS-like | 4,535,834 | 4,578,183 |
Region 13 | RiPP-like | 4,584,491 | 4,595,321 |
Region 14 | phenazine,NRPS | 4,703,796 | 4,761,111 | marinophenazine A / phenaziterpene A | Other:Phenazine | 30%

NC_002516.2 - Region 1 - NRPS-like,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,302,696 - 1,343,373 nt. (total: 40,678 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000427.1 |  |  | 0.64 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  |  | 0.63 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001561.1 |  |  | 0.62 | NRP | curacomycin | Streptomyces curacoi
BGC0000921.1 |  |  | 0.53 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0000846.1 |  |  | 0.51 | Other | tabtoxin | Pseudomonas syringae
BGC0001545.1 |  |  | 0.46 | NRP | chrysogine | Fusarium graminearum PH-1
BGC0001479.1 |  |  | 0.44 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000727.1 |  |  | 0.43 | Saccharide | indigoidine | Streptomyces aureofaciens
BGC0000287.1 |  |  | 0.42 | NRP | L-2-amino-4-methoxy-trans-3-butenoic acid | Pseudomonas aeruginosa PAO1
BGC0001154.1 |  |  | 0.42 | Other | cacibiocin B | Catenulispora acidiphila DSM 44928

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.65 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.65 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001561.1 |  | 0.64 | NRP | curacomycin | Streptomyces curacoi
BGC0000921.1 |  | 0.61 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0000846.1 |  | 0.59 | Other | tabtoxin | Pseudomonas syringae
BGC0001545.1 |  | 0.56 | NRP | chrysogine | Fusarium graminearum PH-1
BGC0000727.1 |  | 0.55 | Saccharide | indigoidine | Streptomyces aureofaciens
BGC0000329.1 |  | 0.55 | NRP | corpeptin A, corpeptin B | Pseudomonas corrugata
BGC0001479.1 |  | 0.55 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001379.1 |  | 0.54 | NRP | BD-12 | Streptomyces luteocolor

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 1302695 - 1343373:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1238: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (19..394): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      GIiyVGifaK
    Nearest Stachelhaus code:
      tcl
    Stachelhaus code match:
      50% (weak)
ctg1_1244: val
  Search NORINE for peptide: strict or relaxed
  AMP-binding (18..410): val
  NRPSPredictor2: val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      val
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALWLGGTFK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      100% (strong)

NC_002516.2 - Region 2 - hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,549,883 - 1,569,709 nt. (total: 19,827 nt) Show pHMM detection rules used
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000496.1 |  | 0.16 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.1 |  | 0.16 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000928.1 |  | 0.15 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.15 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000698.1 |  | 0.15 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0000703.1 |  | 0.15 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001138.1 |  | 0.14 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0000019.1 |  | 0.14 | Polyketide | angolamycin | Streptomyces eurythermus
BGC0001607.1 |  | 0.14 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0000559.1 |  | 0.14 | RiPP | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000496.1 |  | 0.47 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.1 |  | 0.46 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000928.1 |  | 0.45 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.45 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000698.1 |  | 0.45 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0000703.1 |  | 0.44 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001138.1 |  | 0.44 | Other (Nucleoside) | a201a | Marinactinospora thermotolerans
BGC0000019.1 |  | 0.44 | Polyketide | angolamycin | Streptomyces eurythermus
BGC0001607.1 |  | 0.44 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0000559.1 |  | 0.44 | RiPP | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 3 - phenazine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,061,278 - 2,080,664 nt. (total: 19,387 nt) Show pHMM detection rules used
phenazine: phzB

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phenazine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000936.1 |  | 0.83 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0001868.1 |  | 0.28 | Other (Phenazine) | iodinin | Xenorhabdus szentirmaii DSM 16338
BGC0001221.1 |  | 0.22 | Other (Phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0000934.1 |  | 0.21 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001080.1 |  | 0.18 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000294.1 |  | 0.18 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000451.1 |  | 0.17 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0001935.1 |  | 0.17 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.17 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000698.1 |  | 0.17 | Saccharide | hygromycin A | Streptomyces hygroscopicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000936.1 |  | 0.94 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0001868.1 |  | 0.62 | Other (Phenazine) | iodinin | Xenorhabdus szentirmaii DSM 16338
BGC0001221.1 |  | 0.55 | Other (Phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0000934.1 |  | 0.53 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001080.1 |  | 0.50 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000294.1 |  | 0.49 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000451.1 |  | 0.49 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0001935.1 |  | 0.49 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.49 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0000698.1 |  | 0.48 | Saccharide | hygromycin A | Streptomyces hygroscopicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 4 - thiopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,083,444 - 2,116,447 nt. (total: 33,004 nt) Show pHMM detection rules used
thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Thiopeptides
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thiopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.1 |  | 0.22 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000244.1 |  | 0.19 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000451.1 |  | 0.14 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0000466.1 |  | 0.14 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0001412.1 |  | 0.13 | Saccharide | polysaccharide C | Bacteroides fragilis
BGC0000506.1 |  | 0.12 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000295.1 |  | 0.11 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0000395.1 |  | 0.11 | NRP | nocardicin A | Nocardia uniformis subsp. tsuyamanensis
BGC0001791.1 |  | 0.10 | NRP | sunshinamide | Gynuella sunshinyii YC6258
BGC0000699.1 |  | 0.10 | Saccharide | hygromycin A | Streptomyces hygroscopicus subsp. hygroscopicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001285.1 |  | 0.55 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000244.1 |  | 0.51 | Polyketide | macrotetrolide | Streptomyces griseus subsp. griseus
BGC0000451.1 |  | 0.44 | NRP | turnerbactin | Teredinibacter turnerae T7901
BGC0000466.1 |  | 0.43 | NRP | yatakemycin | Streptomyces sp. TP-A2060
BGC0001412.1 |  | 0.41 | Saccharide | polysaccharide C | Bacteroides fragilis
BGC0000506.1 |  | 0.40 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0000295.1 |  | 0.38 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0000395.1 |  | 0.37 | NRP | nocardicin A | Nocardia uniformis subsp. tsuyamanensis
BGC0001791.1 |  | 0.36 | NRP | sunshinamide | Gynuella sunshinyii YC6258
BGC0000699.1 |  | 0.36 | Saccharide | hygromycin A | Streptomyces hygroscopicus subsp. hygroscopicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Thiopeptide predictions
Lists the possible core peptides for each biosynthetic enzyme, including the predicted class. Each core peptide shows the leader and core peptide sequences, separated by a dash. Predicted tail sequences are also shown.
No core peptides found.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
Thiopeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NC_002516.2 - Region 5 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,162,913 - 2,185,057 nt. (total: 22,145 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000842.1 |  | 0.20 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0001921.1 |  | 0.18 | Other | MS-271 | Streptomyces sp.
BGC0001441.1 |  | 0.18 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0002015.1 |  | 0.18 | RiPP | aborycin | Streptomyces sp. ZS0098
BGC0001674.1 |  | 0.17 | RiPP | MS-271 | Streptomyces mirabilis
BGC0000528.1 |  | 0.16 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001920.1 |  | 0.16 | RiPP | siamycin I | Streptomyces sp.
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001669.1 |  | 0.15 | RiPP | microvionin | Microbacterium arborescens
BGC0000703.1 |  | 0.14 | Saccharide | kanamycin | Streptomyces kanamyceticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000842.1 |  | 0.52 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0001921.1 |  | 0.50 | Other | MS-271 | Streptomyces sp.
BGC0001441.1 |  | 0.49 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0002015.1 |  | 0.49 | RiPP | aborycin | Streptomyces sp. ZS0098
BGC0001674.1 |  | 0.48 | RiPP | MS-271 | Streptomyces mirabilis
BGC0000528.1 |  | 0.47 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001920.1 |  | 0.46 | RiPP | siamycin I | Streptomyces sp.
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001669.1 |  | 0.45 | RiPP | microvionin | Microbacterium arborescens
BGC0000703.1 |  | 0.44 | Saccharide | kanamycin | Streptomyces kanamyceticus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 6 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,513,179 - 2,564,072 nt. (total: 50,894 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000287.1 |  | 1.00 | NRP | L-2-amino-4-methoxy-trans-3-butenoic acid | Pseudomonas aeruginosa PAO1
BGC0000375.1 |  | 0.35 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.34 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001527.1 |  | 0.32 | Other | basidioferrin | Gelatoporia subvermispora
BGC0001561.1 |  | 0.32 | NRP | curacomycin | Streptomyces curacoi
BGC0000410.1 |  | 0.32 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000348.1 |  | 0.31 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0002002.1 |  | 0.30 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000876.1 |  | 0.28 | Other | neopolyoxin C | Streptomyces tendae
BGC0001488.1 |  | 0.28 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000287.1 |  | 1.00 | NRP | L-2-amino-4-methoxy-trans-3-butenoic acid | Pseudomonas aeruginosa PAO1
BGC0000375.1 |  | 0.68 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.67 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001527.1 |  | 0.66 | Other | basidioferrin | Gelatoporia subvermispora
BGC0001561.1 |  | 0.65 | NRP | curacomycin | Streptomyces curacoi
BGC0000410.1 |  | 0.65 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000348.1 |  | 0.65 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0002002.1 |  | 0.63 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000876.1 |  | 0.62 | Other | neopolyoxin C | Streptomyces tendae
BGC0001488.1 |  | 0.62 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 2513178 - 2564072:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ala) + (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2355: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (454..848): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DsKDLGlVnK
    Nearest Stachelhaus code:
      asp
    Stachelhaus code match:
      70% (weak)
ctg1_2358: ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (244..633): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNNALTYK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      100% (strong)

NC_002516.2 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,638,928 - 2,739,716 nt. (total: 100,789 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000457.1 |  |  | 0.67 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001833.1 |  |  | 0.63 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.1 |  |  | 0.61 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001758.1 |  |  | 0.61 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000389.1 |  |  | 0.60 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001131.1 |  |  | 0.59 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001671.1 |  |  | 0.59 | NRP | monobactam | Agrobacterium tumefaciens
BGC0000417.1 |  |  | 0.58 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001479.1 |  |  | 0.58 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001132.1 |  |  | 0.58 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.77 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001758.1 |  | 0.70 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.69 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001131.1 |  | 0.68 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001833.1 |  | 0.68 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001615.1 |  | 0.67 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.67 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000426.1 |  | 0.67 | NRP | sevadicin | Paenibacillus larvae
BGC0000465.1 |  | 0.66 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0001185.1 |  | 0.66 | NRP | bacillibactin | Bacillus velezensis FZB42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 2638927 - 2739716:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - D-X - X) + (D-ser - X - D-ser - X) + (X - X) + (thr - thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 2638927 - 2706087:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-ser - X - D-ser - X) + (X - X) + (thr - thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 2688704 - 2739716:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (glu - D-X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2452: thr - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (507..915): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1568..1976): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg1_2453: X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (513..918): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGedhGtVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1573..1974): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgeVcGgVtK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
ctg1_2454: ser - X - ser - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (516..913): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1993..2389): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAedIGAItK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3043..3440): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHVSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4543..4944): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DgeVcGgVtK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
ctg1_2476: pk - glu - X - X
  Search NORINE for peptide: strict or relaxed
  CAL_domain (41..481): pk
  minowa: NH2
  Prediction, score:
    NH2: 164.7
    Acetyl-CoA: 46.5
    AHBA: 12.1
    fatty_acid: 11.8
    shikimic_acid: -2.8
  AMP-binding (1133..1531): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFGRINK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2191..2595): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAegiGAVMK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3718..4128): X
  NRPSPredictor2: asp, asn, glu, gln, aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DiWeLtadDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      50% (weak)

NC_002516.2 - Region 8 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,671,227 - 3,681,461 nt. (total: 10,235 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

No matches found.

No matches found.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 9 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,710,749 - 3,757,593 nt. (total: 46,845 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001873.1 |  | 0.42 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0001615.1 |  | 0.34 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.33 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000457.1 |  | 0.32 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001890.1 |  | 0.31 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001185.1 |  | 0.30 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001903.1 |  | 0.30 | Other | neocarazostatin A | Streptomyces sp. MA37
BGC0000401.1 |  | 0.30 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001437.1 |  | 0.29 | NRP | obafluorin | Pseudomonas fluorescens
BGC0001710.1 |  | 0.29 | NRP | obafluorin | Pseudomonas fluorescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001873.1 |  | 0.73 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0001615.1 |  | 0.67 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000417.1 |  | 0.66 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000457.1 |  | 0.66 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001185.1 |  | 0.64 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001903.1 |  | 0.64 | Other | neocarazostatin A | Streptomyces sp. MA37
BGC0000401.1 |  | 0.63 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001437.1 |  | 0.63 | NRP | obafluorin | Pseudomonas fluorescens
BGC0001710.1 |  | 0.63 | NRP | obafluorin | Pseudomonas fluorescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 3710748 - 3757593:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser - pro)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3405: ser - pro
  Search NORINE for peptide: strict or relaxed
  AMP-binding (450..852): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1480..1877): pro
  NRPSPredictor2: pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      pro, pip
    Small clusters prediction:
      pro
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmQlvsQqVK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      50% (weak)

NC_002516.2 - Region 10 - NAGGN
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,860,897 - 3,875,657 nt. (total: 14,761 nt) Show pHMM detection rules used
NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAGGN | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.1 |  | 0.19 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.1 |  | 0.18 | Other | tabtoxin | Pseudomonas syringae
BGC0000857.1 |  | 0.17 | Other | ectoine | Methylophaga alcalica
BGC0000854.1 |  | 0.17 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000937.1 |  | 0.15 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001374.1 |  | 0.14 | Other | thienodolin | Streptomyces albogriseolus
BGC0001739.1 |  | 0.12 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001545.1 |  | 0.10 | NRP | chrysogine | Fusarium graminearum PH-1
BGC0000842.1 |  | 0.09 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.1 |  | 0.52 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.1 |  | 0.50 | Other | tabtoxin | Pseudomonas syringae
BGC0000857.1 |  | 0.48 | Other | ectoine | Methylophaga alcalica
BGC0000854.1 |  | 0.48 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000937.1 |  | 0.46 | Other | fosfazinomycin A | Streptomyces sp. WM6372
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001374.1 |  | 0.43 | Other | thienodolin | Streptomyces albogriseolus
BGC0001739.1 |  | 0.39 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001545.1 |  | 0.35 | NRP | chrysogine | Fusarium graminearum PH-1
BGC0000842.1 |  | 0.34 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 11 - hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,879,139 - 3,899,744 nt. (total: 20,606 nt) Show pHMM detection rules used
hserlactone: Autoind_synth

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hserlactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000386.1 |  | 0.19 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0000925.1 |  | 0.15 | Other | quinolobactin | Pseudomonas fluorescens
BGC0001149.1 |  | 0.14 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001554.1 |  | 0.13 | Other | coenzyme F430 | Methanosarcina barkeri str. Fusaro
BGC0000344.1 |  | 0.09 | NRP | entolysin | Pseudomonas entomophila L48
BGC0000961.1 |  | 0.08 | NRP, Polyketide | bactobolin | Burkholderia thailandensis E264
BGC0001437.1 |  | 0.08 | NRP | obafluorin | Pseudomonas fluorescens
BGC0001710.1 |  | 0.08 | NRP | obafluorin | Pseudomonas fluorescens
BGC0000199.1 |  | 0.07 | Polyketide, Saccharide | arimetamycin B, arimetamycin C, arimetamycin A | uncultured bacterium
BGC0000340.1 |  | 0.07 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000386.1 |  | 0.51 | NRP | malleobactin A, malleobactin B, malleobactin C, malleobactin D | Burkholderia thailandensis E264
BGC0000925.1 |  | 0.44 | Other | quinolobactin | Pseudomonas fluorescens
BGC0001149.1 |  | 0.44 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001554.1 |  | 0.41 | Other | coenzyme F430 | Methanosarcina barkeri str. Fusaro
BGC0000344.1 |  | 0.34 | NRP | entolysin | Pseudomonas entomophila L48
BGC0000961.1 |  | 0.31 | NRP, Polyketide | bactobolin | Burkholderia thailandensis E264
BGC0001437.1 |  | 0.31 | NRP | obafluorin | Pseudomonas fluorescens
BGC0001710.1 |  | 0.31 | NRP | obafluorin | Pseudomonas fluorescens
BGC0000199.1 |  | 0.29 | Polyketide, Saccharide | arimetamycin B, arimetamycin C, arimetamycin A | uncultured bacterium
BGC0000340.1 |  | 0.29 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 12 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,535,834 - 4,578,183 nt. (total: 42,350 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001900.1 |  | 0.33 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001599.1 |  | 0.30 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001444.1 |  | 0.30 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.30 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001399.1 |  | 0.26 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000679.1 |  | 0.24 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0000204.1 |  | 0.23 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000716.1 |  | 0.23 | Saccharide | spectinomycin | Streptomyces netropsis
BGC0000219.1 |  | 0.23 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000880.1 |  | 0.23 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001900.1 |  | 0.66 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001599.1 |  | 0.64 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001444.1 |  | 0.64 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.64 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000679.1 |  | 0.58 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0000204.1 |  | 0.57 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000716.1 |  | 0.56 | Saccharide | spectinomycin | Streptomyces netropsis
BGC0000219.1 |  | 0.56 | Polyketide, Saccharide | elloramycin | Streptomyces olivaceus
BGC0000880.1 |  | 0.56 | Other (Nucleoside) | tunicamycin B1 | Streptomyces chartreusis NRRL 3882

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 4535833 - 4578183:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_4165: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (9..395): X
  NRPSPredictor2: gly, ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWfFayVfK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      60% (weak)

NC_002516.2 - Region 13 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,584,491 - 4,595,321 nt. (total: 10,831 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000928.1 |  | 0.16 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.16 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000883.1 |  | 0.14 | Other | arginomycin | Streptomyces arginensis
BGC0000043.1 |  | 0.12 | Polyketide | curacin A | Moorea producens 19L
BGC0000527.1 |  | 0.11 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.1 |  | 0.11 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000515.1 |  | 0.10 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0001686.1 |  | 0.10 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000556.1 |  | 0.10 | RiPP | streptin | Streptococcus pyogenes
BGC0001789.1 |  | 0.09 | RiPP | suicin 90-1330 | Streptococcus suis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000928.1 |  | 0.46 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.46 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000883.1 |  | 0.43 | Other | arginomycin | Streptomyces arginensis
BGC0000043.1 |  | 0.39 | Polyketide | curacin A | Moorea producens 19L
BGC0000527.1 |  | 0.38 | RiPP | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.1 |  | 0.37 | RiPP | salivaricin 9 | Streptococcus salivarius
BGC0000515.1 |  | 0.35 | RiPP | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0001686.1 |  | 0.35 | NRP | N-octanoyl-Met-Phe-H | Clostridium sp. CAG:567
BGC0000556.1 |  | 0.35 | RiPP | streptin | Streptococcus pyogenes
BGC0001789.1 |  | 0.33 | RiPP | suicin 90-1330 | Streptococcus suis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_002516.2 - Region 14 - NRPS,phenazine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,703,796 - 4,761,111 nt. (total: 57,316 nt) Show pHMM detection rules used
phenazine: phzB
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phenazine | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000936.1 |  |  | 2.00 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0000412.1 |  |  | 1.00 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0001868.1 |  |  | 0.45 | Other (Phenazine) | iodinin | Xenorhabdus szentirmaii DSM 16338
BGC0001221.1 |  |  | 0.44 | Other (Phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0001080.1 |  |  | 0.44 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0000934.1 |  |  | 0.44 | Other (Phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0001302.1 |  |  | 0.38 | Other | lomofungin | Streptomyces lomondensis
BGC0000698.1 |  |  | 0.34 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0000389.1 |  |  | 0.32 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000465.1 |  |  | 0.32 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000412.1 |  | 1.00 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000936.1 |  | 1.00 | Other | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0000389.1 |  | 0.66 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0000465.1 |  | 0.65 | NRP | xenortide A, xenortide B, xenortide C, xenortide D | Xenorhabdus nematophila ATCC 19061
BGC0000351.1 |  | 0.62 | NRP | exochelin | Mycolicibacterium smegmatis
BGC0001343.1 |  | 0.58 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001080.1 |  | 0.57 | Other (Phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001868.1 |  | 0.57 | Other (Phenazine) | iodinin | Xenorhabdus szentirmaii DSM 16338
BGC0001806.1 |  | 0.57 | NRP | tolaasin A | Pseudomonas tolaasii
BGC0001302.1 |  | 0.56 | Other | lomofungin | Streptomyces lomondensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 16, location 4703795 - 4761111:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (NMe-cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 18, location 4711368 - 4761111:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (NMe-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_4314: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (519..915): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_4315: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (562..950): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
ctg1_4317: sal
  Search NORINE for peptide: strict or relaxed
  AMP-binding (41..445): sal
  NRPSPredictor2: sal
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      TLPAQGVICK
    Nearest Stachelhaus code:
      sal
    Stachelhaus code match:
      100% (strong)