LOCUS       NZ_CP008782.1          10852 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP008782.1 Burkholderia pseudomallei strain Mahidol-1106a
            chromosome 2, complete sequence.
ACCESSION   NZ_CP008782
VERSION     NZ_CP008782.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:40:53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2604566
            Orig. end    :: 2615418
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10852
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2609566:2610418](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5852)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10852
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10852
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="15"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             436..1056
                     /locus_tag="ctg2_1983"
                     /transl_table=11
                     /translation="MNWIAFSHGAMLCASLIVTIGAQNAFILRQGIMRSHVGKIVLLCT
                     LSDMLLIGAGVGGASVLVERYPAFVHAVLYVGLAYLAWFGLSALRRAFKPGHETLDATG
                     AVAAPPAQRAWPIVLMTLAFTWLNPHVYLDTFLLIGTAGAREPEGARGAFAIGAMAVSA
                     VWFVALGYGARLLAPWFKRALAWRVLDGAIGGMVLFLAAVQLR"
     PFAM_domain     475..1044
                     /aSDomain="LysE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01810.20"
                     /description="LysE type translocator"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1983_0714"
                     /evalue="1.50E-36"
                     /label="ctg2_1983"
                     /locus_tag="ctg2_1983"
                     /protein_end="203"
                     /protein_start="13"
                     /score="125.8"
                     /tool="antismash"
                     /translation="ASLIVTIGAQNAFILRQGIMRSHVGKIVLLCTLSDMLLIGAGVGG
                     ASVLVERYPAFVHAVLYVGLAYLAWFGLSALRRAFKPGHETLDATGAVAAPPAQRAWPI
                     VLMTLAFTWLNPHVYLDTFLLIGTAGAREPEGARGAFAIGAMAVSAVWFVALGYGARLL
                     APWFKRALAWRVLDGAIGGMVLFLAAV"
     CDS             complement(1228..2217)
                     /locus_tag="ctg2_1984"
                     /transl_table=11
                     /translation="MARRKLERWSALDLAEGLQLAHAVAALQTLGVVDAMAEPTTAQTL
                     SAACDLDPELLRGVLEYAASRTNLIRKTGDRFAASEHYTAQARFLLNLYAGAYADNASR
                     LATLLRRPALAGTTVDLVAHARAFEASEAGGGALAAIISQLHLNHVLDLGCGAGTLLHA
                     LAADDREFVGWGLDRNPSMCKAARMRARQAGIAARVKVFQGDGRHPGASIPPRVLARVR
                     NVVASQFVNEMFRGGTSRAQAWLRRMRRLLPDRLLVIADYYGRLGHGFQTPHRETLLHD
                     YAQLISGQGVPPPNADAWLAMYRATGCRPLHVIEDRAATTRFVHLVAL"
     PFAM_domain     complement(1594..1770)
                     /aSDomain="Methyltransf_25"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13649.8"
                     /description="Methyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1984_0715"
                     /evalue="3.20E-08"
                     /label="ctg2_1984"
                     /locus_tag="ctg2_1984"
                     /protein_end="208"
                     /protein_start="149"
                     /score="34.2"
                     /tool="antismash"
                     /translation="VLDLGCGAGTLLHALAADDREFVGWGLDRNPSMCKAARMRARQAG
                     IAARVKVFQGDGRH"
     CDS             complement(2231..4174)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 258.6; E-value: 1.7e-78)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_1985"
                     /sec_met_domain="PF04055 (E-value: 6.5e-14, bitscore: 49.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLLVDNLVMPEEGSLAYLDVHPHLGLLALTAVAEADGHRVRIY
                     DPKRLIRDGTLAYDATLYERASRAILAERPDAVGFTALGCSFLFALNVAALLKRREPDL
                     PVLLGGPHATMLHRQILERFPQFDIIVRYEADEILPAVLDCLEQRTFDVIPGLSWRATG
                     RGAPLRFTDGKPKVEELDRLPIASYDHYPVDDLGLSMLRIEAGRGCPFACTFCSTAGFF
                     QRSFRLKSAERLVHELDILHRRYRVSDFKLDHDMFTVNRHKVMAFCEAVAGRGYRWRAS
                     ARIDCVDEALLRKMADAGCVNLYFGVETGSERMQTICRKRLDLRLVEPILAAADSFGIE
                     TTASFITGYPQESGQDQDDTLDMIGRCARRPSCLTQLHMLAPEPGTPLFDEHGAQIAYD
                     GYGGPYNTRLLGPGDEREVLDHPDIFQTYYYYPAALPRARHIFAVEAVDVLRRAGPIIL
                     AYALREFGGRLSRLISAWRRFADETSPGALPDAAGLEAFVAARFGRGHHLHSLFRYALR
                     LSAARAPADVVAEGPYEPDRPCMLAENVGLLEDIHNCEALVDRLRRSNDGAPALGDADV
                     GGLGAYIVRADGEAVTGYWVESGIAAILDLFRAPRSCRAAAQWLAHVTRNDGVDASIFE
                     PLLRRGILVPAR"
     PFAM_domain     complement(3086..3565)
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1985_0717"
                     /evalue="9.00E-13"
                     /label="ctg2_1985"
                     /locus_tag="ctg2_1985"
                     /protein_end="363"
                     /protein_start="203"
                     /score="49.0"
                     /tool="antismash"
                     /translation="EAGRGCPFACTFCSTAGFFQRSFRLKSAERLVHELDILHRRYRVS
                     DFKLDHDMFTVNRHKVMAFCEAVAGRGYRWRASARIDCVDEALLRKMADAGCVNLYFGV
                     ETGSERMQTICRKRLDLRLVEPILAAADSFGIETTASFITGYPQESGQDQDDTLDM"
     PFAM_domain     complement(3749..4111)
                     /aSDomain="B12-binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02310.21"
                     /description="B12 binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1985_0716"
                     /evalue="1.80E-16"
                     /label="ctg2_1985"
                     /locus_tag="ctg2_1985"
                     /protein_end="142"
                     /protein_start="21"
                     /score="60.4"
                     /tool="antismash"
                     /translation="VHPHLGLLALTAVAEADGHRVRIYDPKRLIRDGTLAYDATLYERA
                     SRAILAERPDAVGFTALGCSFLFALNVAALLKRREPDLPVLLGGPHATMLHRQILERFP
                     QFDIIVRYEADEILPAV"
     CDS             complement(4171..5004)
                     /locus_tag="ctg2_1986"
                     /transl_table=11
                     /translation="MNARTIHALIAASTKDPQLIERWRRHPDLLRGAGIAPGDLDWRAL
                     EHFVGLSLKVRHNGLRGDFPLSFRLLSVVGLEIEVFAAYASDCAESGHVFAATPQERAR
                     DLIAFLDRWLDPAQRNHVLLWDILRHEYALACLRQAGDAPLADARPAARHRARATAGGI
                     PTLNGSVVQHVMRCNPDDLAAALHQKEPPLDAVPAVDTYCCYWRSAETGEIRLLRVDTL
                     GYCAIEAIDGRRSAADICHRLLGNRRLLPQFLSSLDQLAGIGIVRFARPLGCAAA"
     CDS             complement(5001..5852)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_1987"
                     /sec_met_domain="DUF692 (E-value: 7.8e-35, bitscore: 117.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAFDRDAGAPRIGLAYGPGMAEFAARHAHLVDYIEVPFELLRFS
                     PTIAELQQTIPFVLHCASLSVAGFVPPDDSTVDAIERTAVRTGTPWIGEHLAYISADPI
                     GEALGGTHEPTSLSYTLCPQLSDETVRRVADNLAVLAPRFPVPLIVENSPQYFSIPGST
                     MGMTDFIRAIADRCDVGLLLDLSHFLITAYNTGADVHREFARLPLERVVEVHLSGMSIQ
                     SGAAWDDHSLPASPILFELLERLLAVARPRALTFEYNWSPYFPLSVLTSHIERARALMG
                     LA"
     PFAM_domain     complement(5016..5816)
                     /aSDomain="DUF692"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05114.15"
                     /description="Protein of unknown function (DUF692)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1987_0718"
                     /evalue="2.10E-39"
                     /label="ctg2_1987"
                     /locus_tag="ctg2_1987"
                     /protein_end="279"
                     /protein_start="12"
                     /score="135.4"
                     /tool="antismash"
                     /translation="IGLAYGPGMAEFAARHAHLVDYIEVPFELLRFSPTIAELQQTIPF
                     VLHCASLSVAGFVPPDDSTVDAIERTAVRTGTPWIGEHLAYISADPIGEALGGTHEPTS
                     LSYTLCPQLSDETVRRVADNLAVLAPRFPVPLIVENSPQYFSIPGSTMGMTDFIRAIAD
                     RCDVGLLLDLSHFLITAYNTGADVHREFARLPLERVVEVHLSGMSIQSGAAWDDHSLPA
                     SPILFELLERLLAVARPRALTFEYNWSPYFPLSVLTSHIERARAL"
     CDS             complement(6026..6226)
                     /locus_tag="ctg2_1988"
                     /transl_table=11
                     /translation="MATKPKKTKGVSVSIEGKLPKMTLDMPVDAKKIKAIQKCLENGKL
                     TITMSKVDLAGGRMGEGYLYD"
     CDS             complement(6376..7782)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 212.7; E-value: 1.6e-64)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_1989"
                     /sec_met_domain="p450 (E-value: 7.4e-35, bitscore: 117.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGLPLSLPRVDSTDSLFADPLAFLARARAQCGDVFVLREHGPIF
                     SRASDCSGVIAVFGEHRLRQVLTETDTFALPMSAAAKMALPKNLVNLNRGLHSMREPEH
                     GRHKRLLTGTANRALFDAHRSGMQTDLSRFCEMLNGDGRISVVSRMRELTAKLASRLFL
                     GPQCEEDAELTFLLSAYFTLRREASSPNAHDPLQYRDALIGAGRQLDRALRARIRRYRK
                     APAGECAGLLQRLATAGQPGSPALSEDEIVGHANVMFVSSTEPVAISLAWLLLVLSQLP
                     DLRRALRAESAARASSPASPYDAPLLERVINETLRLLTPNALMVRATTQAVSLQGVALP
                     ARCEIVVCPFLVHREANAFARPHAFLPSRWETARPSPYEYFPFGAGGHFCAGRNLALSL
                     IGEVLSTLLSRFDFVLDIEQFIDWRIHIMLMPKGDPTLTAHPVDERRDTPSPKWRGPVA
                     ELFHFAPGLS"
     PFAM_domain     complement(6535..7089)
                     /aSDomain="p450"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00067.24"
                     /description="Cytochrome P450"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1989_0719"
                     /evalue="6.20E-34"
                     /label="ctg2_1989"
                     /locus_tag="ctg2_1989"
                     /protein_end="416"
                     /protein_start="231"
                     /score="117.6"
                     /tool="antismash"
                     /translation="LQRLATAGQPGSPALSEDEIVGHANVMFVSSTEPVAISLAWLLLV
                     LSQLPDLRRALRAESAARASSPASPYDAPLLERVINETLRLLTPNALMVRATTQAVSLQ
                     GVALPARCEIVVCPFLVHREANAFARPHAFLPSRWETARPSPYEYFPFGAGGHFCAGRN
                     LALSLIGEVLSTLLSRFDFVLD"
     CDS             8185..8889
                     /locus_tag="ctg2_1990"
                     /transl_table=11
                     /translation="MRHAHRFSRRECGMSDSFGHSPFEMFRQMFGGHRRGGGRHGFGPF
                     GGFGGGPGGFGGFGDDAMPRGRQFSADDLQLLLLALLAEQPSHGYELIKALDTRSSGFY
                     APSPGMVYPALTYLEELGYVTVQAEGNRKRYALADAGRAHLDAQRERVEMLFAKLAHLG
                     RKMEFMRRAFAGEAPAAPEDDTRGWLPEFVEARMALKQALFRRSGANADEQRRIAAILR
                     RAVADIEGRAQG"
     PFAM_domain     8416..8622
                     /aSDomain="PadR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03551.16"
                     /description="Transcriptional regulator PadR-like family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1990_0720"
                     /evalue="2.80E-19"
                     /label="ctg2_1990"
                     /locus_tag="ctg2_1990"
                     /protein_end="146"
                     /protein_start="77"
                     /score="68.9"
                     /tool="antismash"
                     /translation="LLALLAEQPSHGYELIKALDTRSSGFYAPSPGMVYPALTYLEELG
                     YVTVQAEGNRKRYALADAGRAHLD"
     CDS             8929..9756
                     /gene_functions="other (smcogs) SMCOG1200:vibriobactin
                     utilization protein ViuB (Score: 274.2; E-value: 1.6e-83)"
                     /gene_kind="other"
                     /locus_tag="ctg2_1991"
                     /transl_table=11
                     /translation="MTQPTTERAVVRVRHTLKFRLLQVKRVVDVTPHLKRVTLAGDELD
                     DFESASFDDHVKVFFPPPGEDAPARPEFGPNGIVFPQDRPRPVARDFTPRRYDRAAREL
                     DLDFVLHHPGPASQWAAQARVGQTLGIGGPRGSFVIPKDFDWHLLIGDDTALPAVARRL
                     EELPAGTRVAAVLEVADPSAQIAFETDANLYVVWRHRGDAASGERGASRLVDALRELPL
                     PAGEGYVWAAGEAAAMRGVREHLCRERGVAKSRIRASAYWKHGAIAVHESLED"
     PFAM_domain     8995..9339
                     /aSDomain="FAD_binding_9"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08021.13"
                     /description="Siderophore-interacting FAD-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1991_0721"
                     /evalue="2.70E-37"
                     /label="ctg2_1991"
                     /locus_tag="ctg2_1991"
                     /protein_end="137"
                     /protein_start="22"
                     /score="127.8"
                     /tool="antismash"
                     /translation="QVKRVVDVTPHLKRVTLAGDELDDFESASFDDHVKVFFPPPGEDA
                     PARPEFGPNGIVFPQDRPRPVARDFTPRRYDRAARELDLDFVLHHPGPASQWAAQARVG
                     QTLGIGGPRGS"
     PFAM_domain     9361..9723
                     /aSDomain="SIP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04954.15"
                     /description="Siderophore-interacting protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_1991_0722"
                     /evalue="4.70E-39"
                     /label="ctg2_1991"
                     /locus_tag="ctg2_1991"
                     /protein_end="265"
                     /protein_start="144"
                     /score="133.7"
                     /tool="antismash"
                     /translation="DWHLLIGDDTALPAVARRLEELPAGTRVAAVLEVADPSAQIAFET
                     DANLYVVWRHRGDAASGERGASRLVDALRELPLPAGEGYVWAAGEAAAMRGVREHLCRE
                     RGVAKSRIRASAYWKHG"
     CDS             10516..10752
                     /locus_tag="ctg2_1992"
                     /transl_table=11
                     /translation="MTRHHTHAGIPRTLKIVGYCGLAAIALALFVAMCAILKDSALDRE
                     AARQLQNGNVELHGGADVEPGSTNDAAQARTPG"
ORIGIN
        1 cgaaccaggt cgcgacgctg tcgtcgttga cggccacgcg cagcgtcggc cacgcccccg
       61 cttgcgcgcc cgcgaacgcg ggcatgtgcc cggacagctc ggcctccagc atccgcacgc
      121 gctcggtgtg gcggcacagc agcgcgcccg aggtcgtcgc gacgcacggc tgcccgcgct
      181 tcacgagcac gctgcccacg cgctcctcca agagcttcac gcgctgcgac accgccgaag
      241 gcgacacgtt gagcgctttc gccgcccgct cgaacgagcc gtggcggatc acttcggcaa
      301 gcgcatcgag cagtgcatag tcgagcatca gttttcctta atcggcatta gatcatttag
      361 cttttcttac tcaagcgatc atcgcagact agcgcctctt gccccgttag tccaccgccg
      421 gaagccgcaa cgaacatgaa ctggatcgct ttttctcacg gcgcgatgct ctgcgcatcg
      481 ctcatcgtca ccatcggcgc gcagaatgcg ttcatcctcc ggcagggcat catgcgttcg
      541 cacgtcggca agatcgtcct gctctgcacg ctgtcggaca tgctgctgat cggcgcgggc
      601 gtcggcggcg catcggtgct cgtcgagcgc tatccggctt tcgttcatgc cgtgctgtat
      661 gtcggcctcg cctatctcgc atggttcggc ctgagcgcgc tgcgccgcgc gttcaagccc
      721 ggccacgaaa cgctcgatgc gacgggcgcg gttgccgcgc cgcccgcgca gcgcgcctgg
      781 ccgatcgtgc tgatgacgct cgcgttcaca tggctcaacc cgcacgtcta tctggacacg
      841 ttcctgctga tcggcacggc cggcgcgcgc gagccggaag gcgcgcgcgg cgcgttcgcg
      901 atcggcgcga tggcggtcag cgcggtatgg ttcgtcgcgc tcggatacgg cgcgcgattg
      961 ctcgcgccat ggttcaagcg cgcgctcgcg tggcgcgtgc tcgacggcgc gatcggcggc
     1021 atggtgctgt ttctcgcggc ggtgcagttg cgctaacgcg gcggatgcgc gttggcggtg
     1081 ccgacgccat ctgaagcgcg gacggtggca cgcggcgcac ggcggcgagc gagccacgaa
     1141 cgtcatggcc gcacgccccg agggaatcgg ccagccggcg cacgcggtcg gcgcaagcgg
     1201 cgccgccgag ccgcgcccgt catgccgcta cagcgctacc aggtggacga agcgcgtcgt
     1261 ggccgcgcgg tcttcgatca catgcagagg ccggcaaccg gtcgcccgat acatggcgag
     1321 ccacgcgtcg gcattgggcg gcggcacgcc ttgccccgat atgagctgcg catagtcgtg
     1381 cagcagcgtc tcgcggtgcg gcgtttgaaa accgtggccg aggcggccgt agtagtccgc
     1441 gatcacgagc aggcggtcgg gcagcaggcg gcgcatgcgt cgaagccagg cctgcgcgcg
     1501 ggacgtgccg ccgcgaaaca tctcgttgac gaactggctc gcgacgacgt tgcgcacgcg
     1561 cgccagcacg cgcggcggaa tcgacgcgcc gggatgcctg ccgtcgccct gaaacacctt
     1621 cacgcgcgcc gcgattcccg cttgcctcgc ccgcatccgg gcggccttgc acatcgatgg
     1681 attgcgatcc agcccccacc cgacgaattc acgatcgtcc gccgccagcg cgtgcagcag
     1741 cgtgccggcg ccgcatccga gatccagtac gtgattcagg tgcaattggc tgatgatcgc
     1801 ggccagcgcc ccgccgcccg cctcgctcgc ctcgaaggcg cgcgcgtgcg cgacgaggtc
     1861 gaccgtcgtg cccgccagcg ccggccgccg gagcagcgtc gccagccgcg aagcgttatc
     1921 ggcataggcg ccggcataca ggttcagcag gaaacgcgct tgcgccgtgt agtgctcgga
     1981 agccgcgaat cggtcgccgg tcttgcggat caggttcgtt ctcgatgccg cgtattcgag
     2041 gacgcctcgc aacaactcgg gatcgagatc gcacgcggcg ctcagcgttt gcgccgtcgt
     2101 cggctccgcc atcgcatcca cgacgccgag cgtttgcagc gcggcgacgg catgcgccag
     2161 ttgaagacct tccgcgagat ccagcgcgga ccagcgttcg agtttccgac gagccatgag
     2221 cgaaatgaat ttagcgggcc ggcaccaaaa tgcctctgcg cagcagcggc tcgaagatcg
     2281 aagcgtccac gccgtcattg cgggtgacgt gcgccagcca ttgcgcagcg gcgcggcacg
     2341 aacggggcgc cctgaacaga tcgaggatcg cggcaatgcc ggactccacc caatagccgg
     2401 tgacggcttc gccgtccgcg cggacgatat aggcgccgag cccgccgaca tccgcgtcgc
     2461 cgagcgccgg cgcaccgtcg ttcgagcgcc ggagccgatc gaccaacgcc tcgcaattgt
     2521 ggatgtcctc cagcaggccg acgttttcgg ccagcatgca aggccggtcc ggctcatagg
     2581 gcccttcggc gacgacgtcc gccggagcgc gggccgcgga cagccgcaac gcgtaccgga
     2641 aaagagaatg caggtgatgg ccgcggccga atcgcgcggc cacgaaagcc tccagccccg
     2701 ccgcatccgg caacgcgccg ggcgacgttt cgtctgcgaa ccgtcgccat gccgatatca
     2761 gccggctcag ccgtccgccg aattcccgca aagcgtacgc gaggatgatc ggccccgcgc
     2821 ggcgcagcac atccaccgcc tcgacggcaa agatgtgtct cgcgcgcggc agcgcggcgg
     2881 gatagtaata gtaggtttga aatatgtcgg gatggtcgag cacctcgcgc tcgtcccccg
     2941 ggcccagcag gcgcgtgttg taaggcccgc catagccgtc gtaggcgatc tgcgccccgt
     3001 gttcgtcgaa cagcggcgtg ccgggctccg gcgcgagcat gtgcagttgc gtcaggcagg
     3061 acggccgccg cgcgcagcgc ccgatcatgt ccagcgtgtc gtcctggtcc tgcccgcttt
     3121 cctgcggata gccggtgatg aacgacgcgg tcgtctcgat tccgaacgaa tccgccgcgg
     3181 ccagaatggg ctcgaccaac cgcaagtcca accgcttccg gcagattgtc tgcatgcgtt
     3241 cggagccggt ctccacgccg aaataaagat tcacgcagcc cgcgtcggcc atcttcctca
     3301 gcaatgcttc gtcgacgcaa tcgatccgcg ccgacgcgcg ccaccggtag ccgcgcccgg
     3361 ccaccgcctc gcaaaacgcc atcaccttgt ggcgattcac ggtaaacatg tcatggtcga
     3421 gcttgaagtc ggacacgcga tagcgccgat gaaggatgtc cagctcgtgc accaggcgct
     3481 cggcggactt gaggcgaaag ctgcgctgaa agaagcccgc cgtcgaacag aacgtgcatg
     3541 cgaacggaca gccgcggccg gcttcgatgc gcagcatcga gaggcccaga tcgtcgaccg
     3601 gataatggtc gtacgacgcg atcggcagcc ggtccagttc ctcgaccttg ggcttgccgt
     3661 cggtgaagcg caacggcgca ccgcggcccg tcgcgcgcca gctcaagccg gggataacat
     3721 cgaatgtccg ctgctcgagg cagtcgagca cggcgggaag gatctcgtcc gcttcgtagc
     3781 gaacgatgat gtcgaactgc gggaatcgct cgaggatctg ccgatgcagc atcgtcgcgt
     3841 gcgggccgcc gagcaggacc ggcaaatcgg gctcgcgccg cttcagcagc gccgcgacat
     3901 tgagcgcgaa cagaaaactg cagccgagcg cggtgaagcc gaccgcgtcc gggcgctcgg
     3961 cgaggatcgc gcggctcgcc cgctcgtaaa gcgtcgcatc gtaagcgagc gtgccgtccc
     4021 ggatcaggcg cttcggatca tagatccgca cgcgatggcc gtcggcctcg gcgaccgcgg
     4081 tcagcgcgag cagcccgaga tgcggatgca cgtcgagata ggcgagcgag ccctcttccg
     4141 gcatgacgag attgtcgacg agcagcagct tcatgccgcg gcgcatccga gcggccgcgc
     4201 gaatcgcacg atcccgatgc cggccagttg gtcgagcgaa ctcaggaact gcggcagcag
     4261 acggcgattg ccgagcaacc gatggcagat gtcggcggcg gaccgcctgc cgtcgatcgc
     4321 ttcgatcgcg cagtaaccga gcgtatcgac ccgcagcaac cgtatttcgc ccgtttcggc
     4381 ggagcgccaa tagcagcagt aagtgtcgac ggcgggaacc gcgtcgagcg gcggctcctt
     4441 ctgatgaagc gccgccgcca gatcgtcagg attgcagcgc atcacgtgtt gaacgacgga
     4501 gccgttgagc gtcggaatgc cgccggccgt cgcgcgcgcc cgatgacgcg cggcgggacg
     4561 cgcatcggca agcggcgcgt cgcccgcttg ccgcaggcat gcgagcgcgt attcatggcg
     4621 caggatgtcc cacagcagaa cgtgattgcg ttgcgcggga tcgagccatc tatcgagaaa
     4681 cgcaatcaga tcgcgcgcgc gctcctgcgg cgtggcggcg aatacgtggc cgctctccgc
     4741 gcagtccgac gcatacgcgg cgaatacctc gatctcgagg ccgaccacgc tcagcagcct
     4801 gaagctcagc ggaaaatctc cgcgcaggcc gttgtggcgc accttcaggc tcaacccgac
     4861 gaaatgctcc aatgcgcgcc aatcgagatc gccgggcgcg atgcccgcgc cgcgcagcag
     4921 gtccggatgc cgccgccaac gctcgatgag ctgcggatcc ttggtgctgg ccgcgatcag
     4981 cgcgtgtatc gtccttgcgt tcatgcaagc cccatcagcg cgcgcgcgcg ttcgatgtgg
     5041 ctcgtgagga ccgacaacgg gaagtatggc gaccagttgt attcgaaggt cagcgcgcga
     5101 ggccgcgcga cggcgagcag gcgctcgagc agttcgaaga ggatcggcga cgccggcagc
     5161 gaatgatcgt cccaggccgc gccggactgg atgctcatgc cggacaggtg aacttcgacc
     5221 acgcgctcga gcggcagccg ggcgaattcc cggtgcacgt cggcgcccgt gttgtacgcc
     5281 gtgatcagaa aatggctcag atccaggagc aagccgacat cgcaccggtc cgcgatcgcg
     5341 cgaatgaagt cggtcatgcc catcgtgctg ccgggaatcg aaaagtattg gggcgaattt
     5401 tccacgatca gcggaaccgg aaagcgcgga gcgagcacgg cgagattatc ggcgacgcgc
     5461 cgcaccgtct cgtcgctcaa ctgagggcac agcgtgtaag acagcgacgt gggctcatgg
     5521 gtcccaccca gcgcctcgcc gatgggatcg gccgagatgt acgcgagatg ttcgccgatc
     5581 cacggcgtgc cggtgcgcac ggccgtgcgc tcgattgcgt cgacggtcga atcgtcgggc
     5641 ggcacgaatc ccgcaacgga caagctggcg cagtgcagaa cgaacggaat ggtttgctga
     5701 agctcggcaa tcgtcggcga gaatcgcaag agctcgaacg gcacttcgat gtaatcgacg
     5761 agatgcgcat gccgtgcggc gaattccgcc atgccgggcc cgtacgcaag gccgatccgg
     5821 ggtgccccgg catcgcgatc gaacgctttc ataggcttcc cgcgccttca ggcgccgaac
     5881 cgcagcagtc cagatttatc gcccgccatt gcgcgagcgc acgccgaacg cctcgcgttc
     5941 ggcggcgcgg cttctctgcg aagcccgagc atcgaggcga cgagaatgcg gcgcggccgg
     6001 caaggcccgc gcgcgccgcc ggacgtcagt cgtagagata gccctcgccc atgcggccgc
     6061 cggcgagatc caccttgctc atcgtgatcg tcagcttgcc gttttccagg catttctgga
     6121 tggccttgat ctttttcgcg tccaccggca tatccagcgt catcttgggc agcttccctt
     6181 cgatggaaac ggaaacgccc tttgtttttt tgggtttcgt ggccatgatc gttcctttgt
     6241 tgtgggcagg acgcgacgct cagctgtgag tgtggaataa cccccgaaaa tcgccatgcg
     6301 aatcgatgac cgaaaaaatc ccgtcgggtg tgcatgccga tttgcttctg attaaaggat
     6361 gcgccccggt aaatgtcaag aaagccccgg cgcgaaatgg aacagctcgg cgacaggccc
     6421 gcgccatttc ggcgacggcg tgtcgcggcg ttcgtcgacg gggtgcgccg tgagcgtcgg
     6481 gtcgcctttc ggcatcagca tgatatgaat gcgccagtcg ataaactgtt cgatatccaa
     6541 aacgaaatcg aatcgcgata gcagcgtcga cagcacttcg ccaatcagcg acagcgcgag
     6601 attccgcccc gcgcagaaat ggccgccggc gccgaatgga aaatactcgt acggcgacgg
     6661 cctcgccgtc tcccatcggg acggcaagaa tgcatgcggg cgcgcaaacg cgttggcctc
     6721 gcggtgcacg aggaacgggc acacgacaat ctcgcagcgc gcgggaagcg cgacgccttg
     6781 caacgaaacc gcctgcgtcg tggcgcggac catcagcgcg ttgggcgtca ggagccgaag
     6841 cgtctcgttg atgacgcgct cgagcaatgg cgcgtcgtac ggcgaagccg gcgacgatgc
     6901 gcgggcggcg ctttccgcgc gaagcgcacg ccgcagatcg ggcaactgcg acagaacgag
     6961 cagcagccac gccagcgata tcgccaccgg ctccgtgctc gacacgaaca tcacgttggc
     7021 gtggccgacg atctcatcct cggaaagcgc gggcgaaccc ggctggccgg ccgtcgccag
     7081 ccgctggagc agccccgcgc actcgccggc gggcgccttt cgataccgcc ggatccgcgc
     7141 ccgcaacgcg cgatcgagtt gccgcccggc gccgatcagc gcgtcccggt actgcaacgg
     7201 atcgtgcgcg ttgggcgaag acgcctcgcg ccgcaacgtg aaatacgcgc ttagcagaaa
     7261 cgtcagttcg gcatcctcct cacactgcgg cccaagaaaa agacgggacg ccaacttggc
     7321 tgtcagctcg cgcattcggc tcacgacgga aatccggccg tccccgttca gcatttcgca
     7381 aaagcggctc aaatccgttt gcattccgga tcgatgcgcg tcgaacagcg cgcggttggc
     7441 cgttcccgtc aggaggcgct tgtgccggcc gtgctccggc tcgcgcatgc tgtgcaagcc
     7501 gcggttgagg ttgaccagat tcttcggcaa cgccatcttc gccgccgctg acatcggcag
     7561 cgcgaaggta tccgtctcgg tcaagacttg tcgaagccga tgttcgccga acacggcgat
     7621 cacgccgctg caatcgctcg cgcgagaaaa aatcggaccg tgctcccgca gcacgaagac
     7681 gtcgccgcat tgtgcgcgcg ctcgtgcgag aaaagcgagc ggatccgcaa agagcgaatc
     7741 ggtgctgtcg actcgcggaa gcgacagagg gaggccattc atttgcgcgc tgtgtccgtg
     7801 aacgattcgt gccgatcgtg gctacgccgg ttgatcgcta cagcatggct gccgtcacag
     7861 tatcacgtct tccgaagccg cccggccggt accgcccgag cgcgatcgca acgccgtcgc
     7921 gcaatacggc acgccccggg acggataaac atccgccatc gaacgaacgg gccaggggcc
     7981 gggttcgcca tgccgccttc ggccgtcgcc ccacccttgc acgcggcatt ccggtatcgt
     8041 cgcgccctcc gcgtgtcggt accgggcggg acatcgcccg tccggccatc gcactccgcc
     8101 cccatcgttc cccgtttaaa ttccgttgac tttatatctt tcgatatata tctttagata
     8161 catctaaaga cacaggaggc ggacatgcgc cacgctcacc gtttttcgcg ccgcgaatgc
     8221 ggcatgtccg attcgttcgg acacagcccg ttcgagatgt ttcgtcagat gttcggcggc
     8281 catcgccgcg gcggcggccg gcatggcttc ggcccattcg gcggcttcgg cggcggcccc
     8341 ggtgggttcg gcggcttcgg agacgacgcg atgccgcgcg gccgtcaatt cagcgccgac
     8401 gatctgcagt tgctgctgct cgcgctgctc gccgagcagc cgagccacgg ctacgagctg
     8461 atcaaggcgc tcgacacgcg ctcgagcggc ttctacgcgc cgagccccgg catggtgtat
     8521 ccggcgctca cgtatctgga agaactcggc tacgtgacgg tgcaggccga aggcaaccgc
     8581 aagcgttacg cgctcgccga cgcgggccgc gcgcatctcg acgcgcagcg tgaacgcgtc
     8641 gagatgctgt tcgcgaagct cgcgcatctc ggccgcaaga tggaattcat gcgtcgcgcg
     8701 ttcgccggcg aagcgcccgc cgcgcccgag gacgacacgc gcggctggct gccggaattc
     8761 gtcgaagcac ggatggcgct caagcaagcg ctctttcgca gaagcggcgc aaacgccgac
     8821 gagcaacgcc gcatcgcggc cattttgcgg cgcgccgtcg ccgacatcga aggccgcgcg
     8881 caaggctgaa tcgcgccgtt tccggctcat caaggagaac cgatcgacat gacccaaccg
     8941 actaccgagc gcgcggtcgt acgcgtgcgt catacgctga aattccgcct gctgcaggtc
     9001 aagcgcgtcg tcgacgtgac gccgcatctg aagcgcgtga cgctggcagg cgacgaactc
     9061 gacgatttcg aatcggcgtc gttcgacgat cacgtgaaag tcttcttccc gccgcccggc
     9121 gaagacgcac ccgcgcgccc cgaattcggc ccgaacggca tcgtgtttcc gcaggacagg
     9181 ccgcgccccg tcgcacgcga tttcacgccg cgccgctatg atcgcgccgc gcgcgagctc
     9241 gatctcgatt tcgtgctgca tcatccgggg ccggcttcgc agtgggccgc tcaggcgcgc
     9301 gtcgggcaaa cgctcggcat cggcgggccg cgcggttcgt tcgtgattcc gaaggatttc
     9361 gactggcatc tgctgatcgg cgacgacacc gcattgcccg ccgtcgcgcg ccggctcgag
     9421 gaattgccgg ccggcacgcg cgtcgcggcg gtgctcgaag tggccgatcc gtcggcgcag
     9481 atcgcattcg aaaccgatgc gaacctgtat gtggtatggc gacatcgcgg cgatgcggcg
     9541 agcggcgagc gcggcgcgag ccggctggtc gacgcattgc gcgaactgcc gctgccggcg
     9601 ggcgaaggct acgtatgggc ggcgggcgag gcggccgcga tgcgcggcgt gcgcgagcat
     9661 ctgtgccgcg agcgcggcgt cgcgaaatcg cggattcgcg catccgctta ctggaagcac
     9721 ggtgcgatcg ccgtgcacga atcgctcgaa gactgatccg cggccggccg ctgcgcgcgc
     9781 gaatatcgcc cggcgattca cgcgcgcgat ccaagcgcac ggcgtcgccg gcacccgcat
     9841 gccgcattgc aatgcacgcg atagcggccg gcaggcagca cacgcgcgta cgcctcgacc
     9901 ggccatcgcc gaaagcgaaa accgcaaacc ccttcacgcc gccgctacgt tcgccgcgtc
     9961 gcgttttcgc cgtttcgtat gagctgaatc gcgcgcgtac cgctgtcgca tcgcatcggc
    10021 ttgtcttgat tgtcttgaaa tagccgcgca ccgccacgct cgcgatacgt cgctcatggc
    10081 aagcggctct ggttcgcgcc cgatcgcacc gcaccgccgc gccgctcgag cgcagccgcg
    10141 ccgcgctgac ccatcgcatc gcacgccttc gctgccattc cgcgcgccga caaagccgtt
    10201 tcgttcgctt ctccgccgtt ttcccgccga tcaacgccgc agcgacggcg gccggcgcgc
    10261 gcgttcagat gccatcgtcc gcttgcatcg cgcgatgccc tcgcatccgc gcgtctccac
    10321 acgagcggag ttgcatccgc atcgcccgtg tcctatacct atgtcgacgg cacatggcga
    10381 cgccgatggc ggcacaacgg ggcgcgcgcc gccgtgaccg gttagggaaa agcacgacgc
    10441 gcaccgcggt attttcgcgt gtcgaacgag aacgagaccg cgcggcttcg cgcgtcgcca
    10501 cccggatacg cgtccatgac tcgccaccac acccacgccg gcattccgag aacgctcaaa
    10561 atcgtcggct attgcgggct cgccgcaatc gcgctcgcgc tgttcgtcgc gatgtgcgcg
    10621 atcctcaaag acagcgcgct cgatcgcgaa gccgcgcgcc agttgcagaa cgggaacgtc
    10681 gaattgcacg gcggcgccga tgtcgagccg ggctcgacga acgacgccgc ccaggcgaga
    10741 acgccgggtt gatccggatt cctgccgatc ggcgtcagtc gatgcggatc ggccgctcgt
    10801 gcaatcgcgt gaacgcgacc gcgtgcaccg attcgccgac ccggtcgagc ag
//
