LOCUS       NZ_CP014223.1          19016 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP014223.1 Anaerotignum propionicum DSM 1682 strain X2
            chromosome, complete genome.
ACCESSION   NZ_CP014223
VERSION     NZ_CP014223.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:47:46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1227324
            Orig. end    :: 1246340
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1974
                     /locus_tag="ctg1_1178"
                     /transl_table=11
                     /translation="MVNRIKELISLLNKAAEAYYQKDTEIMSNQEYDRLYDELEHLEKE
                     SGIILANSPTQRVGYTVLSNLQKVKHDSPILSLDKTKEPQKLKSFLGGEKGILSWKLDG
                     LTIVLTYENGTLQQAITRGNGEIGEDVTHNARVFANLPLQISFKGSLVLRGEGVISYTE
                     FHRINEGAQEEEKYKNPRNLCSGTVRQLNSEIAAKRRVQFFAFTLVSAEGRLLSDSKAE
                     NLKWLAGLGFDVVDHKIVTAETVEQEVEWFRAYVKKNDIASDGLVLTFDSIDYSENLGS
                     TAKFPKDSIAFKWADEMAETTLREIEWNTSRTGLMNPIAIFDPVELEGSRVSRASVHNV
                     SILRELKLGIGDSIKVYKANMIIPQIAENLTCSDSAEIPKECFVCGGETQIKKQRDGEA
                     LYCTNPECSAQRIQRLTHFVSRDAMNMEGFSEETIKKFLEMGFIQQYPDIFCLEKYEGQ
                     IKKMEGFGEKSYSNLIKSIEKAKQVELPNFIYALGIDQVGLRNAKLLCSKYHYDLDKII
                     HASEDELIGIDGFGTVIAHSIHHYFGEEEHKTLLNCALKYLKIKVPVEIKTEGSLVQGL
                     TFVVTGDLERFSNRKALSEAIELLGGKVTGSVTKKTNYLINNDVFSASSKNEKAKQLGI
                     PIISENDFILQFKIMPDESKNI"
     protocluster    1..19016
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1236055:1236628](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8732..9304
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..19016
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..19016
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     PFAM_domain     7..885
                     /aSDomain="DNA_ligase_aden"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01653.20"
                     /description="NAD-dependent DNA ligase adenylation domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1178_0001"
                     /evalue="3.00E-71"
                     /label="ctg1_1178"
                     /locus_tag="ctg1_1178"
                     /protein_end="295"
                     /protein_start="2"
                     /score="240.2"
                     /tool="antismash"
                     /translation="NRIKELISLLNKAAEAYYQKDTEIMSNQEYDRLYDELEHLEKESG
                     IILANSPTQRVGYTVLSNLQKVKHDSPILSLDKTKEPQKLKSFLGGEKGILSWKLDGLT
                     IVLTYENGTLQQAITRGNGEIGEDVTHNARVFANLPLQISFKGSLVLRGEGVISYTEFH
                     RINEGAQEEEKYKNPRNLCSGTVRQLNSEIAAKRRVQFFAFTLVSAEGRLLSDSKAENL
                     KWLAGLGFDVVDHKIVTAETVEQEVEWFRAYVKKNDIASDGLVLTFDSIDYSENLGSTA
                     KFPKDSIAFKWA"
     aSDomain        25..1929
                     /aSDomain="TIGR00575"
                     /aSTool="tigrfam"
                     /description="dnlj: DNA ligase, NAD-dependent"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1178_0001"
                     /evalue="2.20E-169"
                     /identifier="TIGR00575"
                     /label="ctg1_1178"
                     /locus_tag="ctg1_1178"
                     /protein_end="643"
                     /protein_start="8"
                     /score="562.8"
                     /tool="antismash"
                     /translation="ISLLNKAAEAYYQKDTEIMSNQEYDRLYDELEHLEKESGIILANS
                     PTQRVGYTVLSNLQKVKHDSPILSLDKTKEPQKLKSFLGGEKGILSWKLDGLTIVLTYE
                     NGTLQQAITRGNGEIGEDVTHNARVFANLPLQISFKGSLVLRGEGVISYTEFHRINEGA
                     QEEEKYKNPRNLCSGTVRQLNSEIAAKRRVQFFAFTLVSAEGRLLSDSKAENLKWLAGL
                     GFDVVDHKIVTAETVEQEVEWFRAYVKKNDIASDGLVLTFDSIDYSENLGSTAKFPKDS
                     IAFKWADEMAETTLREIEWNTSRTGLMNPIAIFDPVELEGSRVSRASVHNVSILRELKL
                     GIGDSIKVYKANMIIPQIAENLTCSDSAEIPKECFVCGGETQIKKQRDGEALYCTNPEC
                     SAQRIQRLTHFVSRDAMNMEGFSEETIKKFLEMGFIQQYPDIFCLEKYEGQIKKMEGFG
                     EKSYSNLIKSIEKAKQVELPNFIYALGIDQVGLRNAKLLCSKYHYDLDKIIHASEDELI
                     GIDGFGTVIAHSIHHYFGEEEHKTLLNCALKYLKIKVPVEIKTEGSLVQGLTFVVTGDL
                     ERFSNRKALSEAIELLGGKVTGSVTKKTNYLINNDVFSASSKNEKAKQLGIPIISENDF
                     "
     PFAM_domain     898..1110
                     /aSDomain="DNA_ligase_OB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03120.18"
                     /description="NAD-dependent DNA ligase OB-fold domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1178_0002"
                     /evalue="4.20E-20"
                     /label="ctg1_1178"
                     /locus_tag="ctg1_1178"
                     /protein_end="370"
                     /protein_start="299"
                     /score="71.5"
                     /tool="antismash"
                     /translation="ETTLREIEWNTSRTGLMNPIAIFDPVELEGSRVSRASVHNVSILR
                     ELKLGIGDSIKVYKANMIIPQIAENL"
     PFAM_domain     1462..1650
                     /aSDomain="HHH_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12826.9"
                     /description="Helix-hairpin-helix motif"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1178_0003"
                     /evalue="4.10E-17"
                     /label="ctg1_1178"
                     /locus_tag="ctg1_1178"
                     /protein_end="550"
                     /protein_start="487"
                     /score="62.2"
                     /tool="antismash"
                     /translation="FIYALGIDQVGLRNAKLLCSKYHYDLDKIIHASEDELIGIDGFGT
                     VIAHSIHHYFGEEEHKTL"
     PFAM_domain     1714..1923
                     /aSDomain="BRCT"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00533.28"
                     /description="BRCA1 C Terminus (BRCT) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1178_0004"
                     /evalue="2.50E-10"
                     /label="ctg1_1178"
                     /locus_tag="ctg1_1178"
                     /protein_end="641"
                     /protein_start="571"
                     /score="40.7"
                     /tool="antismash"
                     /translation="LVQGLTFVVTGDLERFSNRKALSEAIELLGGKVTGSVTKKTNYLI
                     NNDVFSASSKNEKAKQLGIPIISEN"
     CDS             complement(2207..3028)
                     /gene_functions="transport (smcogs) SMCOG1044:ABC
                     transporter, permease protein (Score: 171.1; E-value:
                     3.7e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1179"
                     /transl_table=11
                     /translation="MWHKQKDTKFMSKEQAAFLNRLQRRKNAIHGIQWILLIGFFLLWE
                     IAARVGWIDPFIFSQPSRMLSAGMQMGKDGTLWTHIGTTLWETVAGFVLGTILGTLTAI
                     LLWWNRFISDIAEPYLVVLNSLPKTALAPIIIVWLGNNQTSIIAVALLTSVIVTVMSVL
                     NGFLQVDAEKIKLIQIFGGTKAQVLKKVVFPANIPCILNALKINVGLSFVGVIVGEFLV
                     AQSGLGFLIVYGSQIFKLDWVMLSVIILAILAALMYEGIALLEKKCLKWQQ"
     PFAM_domain     complement(2261..2746)
                     /aSDomain="BPD_transp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00528.24"
                     /description="Binding-protein-dependent transport system
                     inner membrane component"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1179_0005"
                     /evalue="1.60E-18"
                     /label="ctg1_1179"
                     /locus_tag="ctg1_1179"
                     /protein_end="256"
                     /protein_start="94"
                     /score="67.2"
                     /tool="antismash"
                     /translation="GTILGTLTAILLWWNRFISDIAEPYLVVLNSLPKTALAPIIIVWL
                     GNNQTSIIAVALLTSVIVTVMSVLNGFLQVDAEKIKLIQIFGGTKAQVLKKVVFPANIP
                     CILNALKINVGLSFVGVIVGEFLVAQSGLGFLIVYGSQIFKLDWVMLSVIILAILAAL"
     CDS             complement(3018..3764)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 187.1; E-value:
                     6.5e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1180"
                     /transl_table=11
                     /translation="MHPIVSLEDVSLRYHSVNGETLAVSNLNLSVQAGEFLSIVGPSGC
                     GKSSLLSMLAGLITPSHGKISVNGEIGYMLQKDYLLEWRTIRNNALLGLEIQNKLTSEN
                     IAFVEALLDQYGLADFKEHYPYQLSGGMRQRVALIRTLAIRPDILLLDEPFSALDYQTR
                     LSVSDEIGSIIRKEGKTAILVSHDISEAISLADRVVVLSSRPAQVKRIYDIQLSIDEYS
                     PIKAREAPEFREYFNAIWKELDVHVA"
     PFAM_domain     complement(3300..3692)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1180_0006"
                     /evalue="6.30E-28"
                     /label="ctg1_1180"
                     /locus_tag="ctg1_1180"
                     /protein_end="155"
                     /protein_start="24"
                     /score="98.1"
                     /tool="antismash"
                     /translation="SNLNLSVQAGEFLSIVGPSGCGKSSLLSMLAGLITPSHGKISVNG
                     EIGYMLQKDYLLEWRTIRNNALLGLEIQNKLTSENIAFVEALLDQYGLADFKEHYPYQL
                     SGGMRQRVALIRTLAIRPDILLLDEPF"
     CDS             complement(4074..4250)
                     /locus_tag="ctg1_1181"
                     /transl_table=11
                     /translation="VINEDQVTDGADILVVAATVPANIGGGSNTGCGKAADLVESKMFL
                     HQSMIIGKWKRIK"
     CDS             5026..5400
                     /locus_tag="ctg1_1182"
                     /transl_table=11
                     /translation="MGCKMDSEILKSSGIDFDKGVARFLGDRQLYESILITFLYDDTFE
                     KGKAALETENYKNLYEFVHTLKGVAGNTDMTTLYLTTAVLSEYLRKCEVPEKDRVFHLF
                     CGMEEAYYAVMKGIAAAKEA"
     CDS             5408..7960
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 1.8; E-value: 2.6)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_1183"
                     /transl_table=11
                     /translation="MDADIGKKTILIADDAEPNRLLLKKIFGGEYYVEEAVNGVEALEK
                     LRQLEDVAILILDIVMPLMDGFSVLEEMQKDEILRTIPTVVITANNEEDIQIRALSCGA
                     TDVMAKPFSPLIILHRIKNIMARKDSEKLAEQNRAYRLELKLMDTDEKSGLFNKNAFHR
                     YTKKMLQKNSDKKFVLIRWDIDNFKVFNDWFGTEVGDTYLKKIGDFFREYEEKNDSVKT
                     YARYDADHFVCCQEAEGFDPEEITQIIDDYMTHLKTIEFEYTPRVGLYLINDPSLDVAL
                     MCDRALLALRSIKDSYGKRYAWFDDSMREALLEQQEIVNEMEFALRDGQFITYFQPQYN
                     YETGKMIGAEALVRWQHPRKGTILPNKFIPLFERNGFISRLDEYMWEQVCIQLKDWERK
                     GLNLVPISVNVSRRDIYNPHLVGNILSLLQEYELSPEMLHLEITESAYTQNAEQLVNTV
                     NLLRIHGIEVHMDDFGSGYSSLNMLQNVPVDILKLDMRFLGGDYKDERSGNILNAVVRM
                     ATALRLPVLAEGVETKEQAEFLRSIGCLLMQGYLFSRPMAVEDFEKLLDGSQTVSALDK
                     SYVESFQGSIDLLSFTSQSTLLFNCFVGGAAVVEYDEKDEVLLALRINDQFLREIGITR
                     MEYAEDGQSIFRYYEGENRVLVISMLQEAIHTGKETCCEIMRKSKLHDMEDNWFKLRAR
                     LLKNSMSKHFFYVTMENITIYKEQTVENEKLVHCLSALTNHVDEGLLVLELSENIKIQY
                     SNVRIAEMFGYTQKEFQELFGNDFLLSIHPDDKVLARENFEQILRAGNGVGRRIYRQTC
                     KNGYYEWVSMTGCVVETEKDHICICTTIEKDDENKQRY"
     PFAM_domain     5435..5770
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1183_0007"
                     /evalue="2.30E-20"
                     /label="ctg1_1183"
                     /locus_tag="ctg1_1183"
                     /protein_end="121"
                     /protein_start="9"
                     /score="72.9"
                     /tool="antismash"
                     /translation="ILIADDAEPNRLLLKKIFGGEYYVEEAVNGVEALEKLRQLEDVAI
                     LILDIVMPLMDGFSVLEEMQKDEILRTIPTVVITANNEEDIQIRALSCGATDVMAKPFS
                     PLIILHRI"
     aSDomain        5852..6199
                     /aSDomain="TIGR00254"
                     /aSTool="tigrfam"
                     /description="GGDEF: diguanylate cyclase (GGDEF) domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1183_0002"
                     /evalue="4.20E-12"
                     /identifier="TIGR00254"
                     /label="ctg1_1183"
                     /locus_tag="ctg1_1183"
                     /protein_end="264"
                     /protein_start="148"
                     /score="44.0"
                     /tool="antismash"
                     /translation="TDEKSGLFNKNAFHRYTKKMLQKNSDKKFVLIRWDIDNFKVFNDW
                     FGTEVGDTYLKKIGDFFREYEEKNDSVKTYARYDADHFVCCQEAEGFDPEEITQIIDDY
                     MTHLKTIEFEYT"
     PFAM_domain     5852..6289
                     /aSDomain="GGDEF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00990.23"
                     /description="Diguanylate cyclase, GGDEF domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1183_0008"
                     /evalue="4.60E-14"
                     /label="ctg1_1183"
                     /locus_tag="ctg1_1183"
                     /protein_end="294"
                     /protein_start="148"
                     /score="52.6"
                     /tool="antismash"
                     /translation="TDEKSGLFNKNAFHRYTKKMLQKNSDKKFVLIRWDIDNFKVFNDW
                     FGTEVGDTYLKKIGDFFREYEEKNDSVKTYARYDADHFVCCQEAEGFDPEEITQIIDDY
                     MTHLKTIEFEYTPRVGLYLINDPSLDVALMCDRALLALRSIK"
     PFAM_domain     6380..7072
                     /aSDomain="EAL"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00563.22"
                     /description="EAL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1183_0009"
                     /evalue="1.00E-69"
                     /label="ctg1_1183"
                     /locus_tag="ctg1_1183"
                     /protein_end="555"
                     /protein_start="324"
                     /score="234.7"
                     /tool="antismash"
                     /translation="ALRDGQFITYFQPQYNYETGKMIGAEALVRWQHPRKGTILPNKFI
                     PLFERNGFISRLDEYMWEQVCIQLKDWERKGLNLVPISVNVSRRDIYNPHLVGNILSLL
                     QEYELSPEMLHLEITESAYTQNAEQLVNTVNLLRIHGIEVHMDDFGSGYSSLNMLQNVP
                     VDILKLDMRFLGGDYKDERSGNILNAVVRMATALRLPVLAEGVETKEQAEFLRSIGCLL
                     MQGYLFSRP"
     aSDomain        7598..7924
                     /aSDomain="TIGR00229"
                     /aSTool="tigrfam"
                     /description="sensory_box: PAS domain S-box protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1183_0003"
                     /evalue="1.60E-07"
                     /identifier="TIGR00229"
                     /label="ctg1_1183"
                     /locus_tag="ctg1_1183"
                     /protein_end="839"
                     /protein_start="730"
                     /score="29.5"
                     /tool="antismash"
                     /translation="ALTNHVDEGLLVLELSENIKIQYSNVRIAEMFGYTQKEFQELFGN
                     DFLLSIHPDDKVLARENFEQILRAGNGVGRRIYRQTCKNGYYEWVSMTGCVVETEKDHI
                     CICTT"
     PFAM_domain     7664..7909
                     /aSDomain="PAS_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08447.14"
                     /description="PAS fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1183_0010"
                     /evalue="7.20E-12"
                     /label="ctg1_1183"
                     /locus_tag="ctg1_1183"
                     /protein_end="834"
                     /protein_start="752"
                     /score="45.5"
                     /tool="antismash"
                     /translation="YSNVRIAEMFGYTQKEFQELFGNDFLLSIHPDDKVLARENFEQIL
                     RAGNGVGRRIYRQTCKNGYYEWVSMTGCVVETEKDHI"
     CDS             8732..9304
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1184"
                     /sec_met_domain="AgrB (E-value: 3e-36, bitscore: 121.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLSKGLQEDDKDIYLFGVYQGAILLLNICTALLIGVALNMLLEI
                     VIYLICFLPLRIFAGGYHAKTQLRCYIMSSFTTVIILLGIQFLQQQESIWEFLSYIVSF
                     GIIWRFAPVADANKPLLEKEHVIYQKKVRKVLLLLTGIAALTYFLGFNIISTVIEVSVC
                     FLSVILLMGIYKNKVHCNNIEELECNK"
     PFAM_domain     8753..9241
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1184_0011"
                     /evalue="1.40E-35"
                     /label="ctg1_1184"
                     /locus_tag="ctg1_1184"
                     /protein_end="170"
                     /protein_start="7"
                     /score="122.5"
                     /tool="antismash"
                     /translation="QEDDKDIYLFGVYQGAILLLNICTALLIGVALNMLLEIVIYLICF
                     LPLRIFAGGYHAKTQLRCYIMSSFTTVIILLGIQFLQQQESIWEFLSYIVSFGIIWRFA
                     PVADANKPLLEKEHVIYQKKVRKVLLLLTGIAALTYFLGFNIISTVIEVSVCFLSVILL
                     "
     CDS             complement(9576..10847)
                     /locus_tag="ctg1_1185"
                     /transl_table=11
                     /translation="MEAISYNEVIYLISNAFRIFAIKLFLEFFFFKKNLRWQPWTQTAV
                     LFLYFIINSGVYLFARNPVLTVITNAVLFVVLTLPYRASIGRRLFATCSIFMIGVICEG
                     IVARTAILLYGLCPKIEIITYVVSNFLLYFIILIMRRFFIEREDIYLPKLHWLCITIIP
                     CISSIADISLILGGYEQWVNVTVISSLFIINIAFFYLYAQVVEKYEVEMQNQSLSHQNK
                     AYQQQLVVIRTAEDNMKRLQHDFKNHLIAIKELSSNCNTENFKEYFQALEEKIDMKSEF
                     VMTGNESLDGLINYKLQTLYDLGVKVELNINIPQNINIHAFDEIVILGNLLDNAIRALQ
                     EQENGFFRMDFVYDRGTILLHIRNSFLGEIKKKGNTFFSTKKDSNEPHGIGLSNVKRIV
                     EKYSGVLTILTEENYFDVEIVMYV"
     PFAM_domain     complement(9585..9887)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1185_0012"
                     /evalue="2.90E-21"
                     /label="ctg1_1185"
                     /locus_tag="ctg1_1185"
                     /protein_end="421"
                     /protein_start="320"
                     /score="75.3"
                     /tool="antismash"
                     /translation="AFDEIVILGNLLDNAIRALQEQENGFFRMDFVYDRGTILLHIRNS
                     FLGEIKKKGNTFFSTKKDSNEPHGIGLSNVKRIVEKYSGVLTILTEENYFDVEIVM"
     CDS             complement(10849..11562)
                     /locus_tag="ctg1_1186"
                     /transl_table=11
                     /translation="MFKIAICDDNKILCTQIEKQIDEFFSTEMINYDIEVFFTGEEILT
                     NLKEKEKYDLIFLDIELDRINGIHVGRYIREELLDDNTQIAFISAKSSYALDLFQVRPI
                     HFLIKPIAKDQIFKIIEKTLELQGRQTKFFCYKSERTEKRVSFRDILYFSSEGKKIFLH
                     MKNGKDYFYGKLSDLIVPSEDFLCIHKSFIVNRHCVIQFKFDRVLLSNSQELPISRIYR
                     KEVRKQLNLLQREVL"
     PFAM_domain     complement(10876..11133)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1186_0014"
                     /evalue="1.80E-16"
                     /label="ctg1_1186"
                     /locus_tag="ctg1_1186"
                     /protein_end="229"
                     /protein_start="143"
                     /score="60.2"
                     /tool="antismash"
                     /translation="RVSFRDILYFSSEGKKIFLHMKNGKDYFYGKLSDLIVPSEDFLCI
                     HKSFIVNRHCVIQFKFDRVLLSNSQELPISRIYRKEVRKQL"
     PFAM_domain     complement(11203..11553)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1186_0013"
                     /evalue="2.40E-15"
                     /label="ctg1_1186"
                     /locus_tag="ctg1_1186"
                     /protein_end="120"
                     /protein_start="3"
                     /score="56.8"
                     /tool="antismash"
                     /translation="IAICDDNKILCTQIEKQIDEFFSTEMINYDIEVFFTGEEILTNLK
                     EKEKYDLIFLDIELDRINGIHVGRYIREELLDDNTQIAFISAKSSYALDLFQVRPIHFL
                     IKPIAKDQIFKII"
     CDS             12413..12541
                     /locus_tag="ctg1_1187"
                     /transl_table=11
                     /translation="MTKMNLDIKRVENFFVYVLVKSNVKNCKPIIFSENKRKRDME"
     CDS             12538..14334
                     /gene_functions="other (smcogs) SMCOG1061:methyl-accepting
                     chemotaxis protein (Score: 245.3; E-value: 2.2e-74)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1188"
                     /transl_table=11
                     /translation="MKQWFENAKVSKKLSIGFLLTVFLGLIIGIVGIGNMLNMLSRQQK
                     TYDQNTLGIAYSTEAEISFKDVRTSIRDLYIYYDINKQKYCNAITNEMNDIQTQLDHYA
                     SRIANEQDQQNFDVAQQAFKNYKNVVDEIVQAANNGDSKDSILVLIKEGASVGNDTSNA
                     FNTLTEYNNLAAKENLDNEKTTSWIAIILMAVTIVISVIIAILMSKFISNIISRPMQML
                     VMVAEHLEIGDVDVYNLMSEEDKKVKYRKDEIGKVALAFNKLIQANIALSKEAETVATG
                     DLTTTVTVRCEKDIIGKALRDLVEKLHSLISSVAITSEQVDFGARQVSDGAQALSAGTT
                     EQAASLEELTSAVANISEQAVNNAASVQKAGEYVNQAGKGVVSSSEQMEKLNHAMKEIG
                     QSSLQISKITKLVEDIAFQTNILALNAAVEAARAGNAGKGFAVVADEVRNLAAKSAEAA
                     KQTADLIQRSTILVSEGEVLADKTVQLLIDVSEKAAMVENSIIEIESASSSQATAIEQI
                     NQGLSQVSAVIQTNAATSEESSAASEELAAQAQVLKQEITHFKLTREKENYSIRENETA
                     FSENQGEQTVYLNPSINDYVKY"
     PFAM_domain     12556..13086
                     /aSDomain="4HB_MCP_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12729.9"
                     /description="Four helix bundle sensory module for signal
                     transduction"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1188_0015"
                     /evalue="2.50E-21"
                     /label="ctg1_1188"
                     /locus_tag="ctg1_1188"
                     /protein_end="183"
                     /protein_start="6"
                     /score="76.1"
                     /tool="antismash"
                     /translation="NAKVSKKLSIGFLLTVFLGLIIGIVGIGNMLNMLSRQQKTYDQNT
                     LGIAYSTEAEISFKDVRTSIRDLYIYYDINKQKYCNAITNEMNDIQTQLDHYASRIANE
                     QDQQNFDVAQQAFKNYKNVVDEIVQAANNGDSKDSILVLIKEGASVGNDTSNAFNTLTE
                     YNNLAAKENLDNEK"
     PFAM_domain     13165..13335
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1188_0016"
                     /evalue="3.30E-03"
                     /label="ctg1_1188"
                     /locus_tag="ctg1_1188"
                     /protein_end="266"
                     /protein_start="209"
                     /score="17.9"
                     /tool="antismash"
                     /translation="FISNIISRPMQMLVMVAEHLEIGDVDVYNLMSEEDKKVKYRKDEI
                     GKVALAFNKLIQ"
     PFAM_domain     13663..14118
                     /aSDomain="MCPsignal"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00015.23"
                     /description="Methyl-accepting chemotaxis protein (MCP)
                     signalling domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1188_0017"
                     /evalue="8.30E-39"
                     /label="ctg1_1188"
                     /locus_tag="ctg1_1188"
                     /protein_end="527"
                     /protein_start="375"
                     /score="133.2"
                     /tool="antismash"
                     /translation="QAGKGVVSSSEQMEKLNHAMKEIGQSSLQISKITKLVEDIAFQTN
                     ILALNAAVEAARAGNAGKGFAVVADEVRNLAAKSAEAAKQTADLIQRSTILVSEGEVLA
                     DKTVQLLIDVSEKAAMVENSIIEIESASSSQATAIEQINQGLSQVSAV"
     CDS             14798..15940
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 152; E-value: 5.1e-46)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1189"
                     /transl_table=11
                     /translation="MARRGENIYKRKDSRWEARLLIQKGKYRYFYGKTYKEAKLKMRLF
                     QENIKIHKEKQAEQKTNAYVLFEGWLQKQVTLNNVKPLTYESYYHCMHKHIMPFFQNEQ
                     TNRITIETVSQFTKTVSENELLADTSKKKIFTIFKIALREILKDELNSASILAAVKSPK
                     LETREVEIFSIKEQRSLEAAALQSQDQRALGIILCLYTGIRLGELCALTWGDIDWDSGF
                     MSITKTVSRVKTFKQDTKKTELIVGTPKSRNSMRKIPVPEFLLKLVRHRKLWEENEDAF
                     VLSGKETPIDPRIFQKLYKKLLVDAHLRDRKFHAIRHTFATRGLELGVDIKTISEILGH
                     SNVSITLNIYAHSLIEQKKAAMEKYNAMHIASAEISKYAV"
     PFAM_domain     15365..15859
                     /aSDomain="Phage_integrase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00589.24"
                     /description="Phage integrase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1189_0018"
                     /evalue="3.90E-26"
                     /label="ctg1_1189"
                     /locus_tag="ctg1_1189"
                     /protein_end="354"
                     /protein_start="189"
                     /score="92.0"
                     /tool="antismash"
                     /translation="QRALGIILCLYTGIRLGELCALTWGDIDWDSGFMSITKTVSRVKT
                     FKQDTKKTELIVGTPKSRNSMRKIPVPEFLLKLVRHRKLWEENEDAFVLSGKETPIDPR
                     IFQKLYKKLLVDAHLRDRKFHAIRHTFATRGLELGVDIKTISEILGHSNVSITLNIYAH
                     SL"
     CDS             16409..17086
                     /locus_tag="ctg1_1190"
                     /transl_table=11
                     /translation="LFEFFQGLTADELIHMLPEDQIRHSLNVEILVGKLVEWLPKPEEV
                     QLFEYYSRAAYYHDIGKVCVPPYILNKTGALTVEERYIIRCHTIYAQDLLAFYRESGSG
                     EIPLFLLPLTVQAAVYHHEWWNGKGYPYGLSGADIPYVARLTSICDAYDAMVSNRPYHL
                     AFTHEYACEEIRRGAGTQFDPVLAKVFLKHKKEIARIINEICTYPTDKLEFEIKRLLIT
                     KQN"
     PFAM_domain     16628..16843
                     /aSDomain="HD_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13487.8"
                     /description="HD domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1190_0019"
                     /evalue="9.00E-14"
                     /label="ctg1_1190"
                     /locus_tag="ctg1_1190"
                     /protein_end="145"
                     /protein_start="73"
                     /score="51.5"
                     /tool="antismash"
                     /translation="GALTVEERYIIRCHTIYAQDLLAFYRESGSGEIPLFLLPLTVQAA
                     VYHHEWWNGKGYPYGLSGADIPYVARL"
     CDS             17288..17470
                     /locus_tag="ctg1_1191"
                     /transl_table=11
                     /translation="MVRYCKRSEFPCMNHNRLKKMKEEFISRIGSYEQIERFFKMPNLP
                     RVKTFRLGNKRVEII"
     CDS             complement(17697..19016)
                     /locus_tag="ctg1_1192"
                     /transl_table=11
                     /translation="MKEKKKGIGDIAVIGMALFATFFGAGNLIFPPYLGINAGSDWFIG
                     FLCFFVADVGVALAAIFAMIKTGDISINGLTGKLGKAPSFIMNILIVLCIGPFLCIPRT
                     AATTFEMGVMPIFPSINSWVFGAIFFGLVLLFTIRPSGVIDVIGKFFTPALVACLLGLI
                     VIGYLHPIGDIVATTNFDTAKEGVLAGYQTMDVLVSIVFIITIVTTAQSKGYSEKKSTV
                     KIITQSSFFAAVALFIVYGGLCYLGATTSAGGFENYNQSILLVAITQKLIGSYGILILG
                     IIVFFACMTTAIGLVSSCASVFVEMTNNKISYTKIIVIEIIFSYFISNFGISTIISIAG
                     PILTLLYPVILVMIILSFFANKIKNNNIYIGAAALALLASAADVSIGYGLPFEFVKNLP
                     LATFQCGWVIPAIIGGIIGKFIPMSEKALLASKNEQADLA"
     PFAM_domain     complement(17751..18989)
                     /aSDomain="Branch_AA_trans"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05525.15"
                     /description="Branched-chain amino acid transport protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1192_0020"
                     /evalue="4.10E-102"
                     /label="ctg1_1192"
                     /locus_tag="ctg1_1192"
                     /protein_end="422"
                     /protein_start="9"
                     /score="342.4"
                     /tool="antismash"
                     /translation="DIAVIGMALFATFFGAGNLIFPPYLGINAGSDWFIGFLCFFVADV
                     GVALAAIFAMIKTGDISINGLTGKLGKAPSFIMNILIVLCIGPFLCIPRTAATTFEMGV
                     MPIFPSINSWVFGAIFFGLVLLFTIRPSGVIDVIGKFFTPALVACLLGLIVIGYLHPIG
                     DIVATTNFDTAKEGVLAGYQTMDVLVSIVFIITIVTTAQSKGYSEKKSTVKIITQSSFF
                     AAVALFIVYGGLCYLGATTSAGGFENYNQSILLVAITQKLIGSYGILILGIIVFFACMT
                     TAIGLVSSCASVFVEMTNNKISYTKIIVIEIIFSYFISNFGISTIISIAGPILTLLYPV
                     ILVMIILSFFANKIKNNNIYIGAAALALLASAADVSIGYGLPFEFVKNLPLATFQCGWV
                     IPAIIGGIIGKFIP"
     aSDomain        complement(17787..18974)
                     /aSDomain="TIGR00796"
                     /aSTool="tigrfam"
                     /description="livcs: branched-chain amino acid transport
                     system II carrier protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1192_0004"
                     /evalue="2.30E-91"
                     /identifier="TIGR00796"
                     /label="ctg1_1192"
                     /locus_tag="ctg1_1192"
                     /protein_end="410"
                     /protein_start="14"
                     /score="304.8"
                     /tool="antismash"
                     /translation="GMALFATFFGAGNLIFPPYLGINAGSDWFIGFLCFFVADVGVALA
                     AIFAMIKTGDISINGLTGKLGKAPSFIMNILIVLCIGPFLCIPRTAATTFEMGVMPIFP
                     SINSWVFGAIFFGLVLLFTIRPSGVIDVIGKFFTPALVACLLGLIVIGYLHPIGDIVAT
                     TNFDTAKEGVLAGYQTMDVLVSIVFIITIVTTAQSKGYSEKKSTVKIITQSSFFAAVAL
                     FIVYGGLCYLGATTSAGGFENYNQSILLVAITQKLIGSYGILILGIIVFFACMTTAIGL
                     VSSCASVFVEMTNNKISYTKIIVIEIIFSYFISNFGISTIISIAGPILTLLYPVILVMI
                     ILSFFANKIKNNNIYIGAAALALLASAADVSIGYGLPFEFVKNLPLATFQCGWVIP"
ORIGIN
        1 atggtaaacc ggataaagga attgatttct cttttgaata aggcggctga agcgtattat
       61 caaaaggata cagaaataat gtctaatcag gagtatgatc gtttgtatga tgaactggag
      121 catttggaaa aggaaagcgg catcatactg gccaatagcc ctacccaaag ggttggttat
      181 accgtattga gtaatttgca aaaggtgaag catgacagcc ccatattatc tttagataaa
      241 acaaaagaac cacaaaaatt aaaaagcttt ttaggcggag aaaagggaat tctttcttgg
      301 aaattagatg gattaaccat tgtattaaca tacgaaaatg ggacacttca gcaggcaata
      361 acccggggaa atggggaaat cggcgaggat gtcacccata atgcaagggt ctttgctaat
      421 ttaccgttgc aaattagctt taaaggaagc ttggttcttc gtggagaagg cgtgatttct
      481 tatacagagt ttcatcgcat aaacgaagga gctcaggaag aagagaaata caagaatcct
      541 agaaatcttt gcagtggtac ggtacgacag cttaatagtg aaattgccgc gaaaagaaga
      601 gtccagttct ttgcatttac attggtaagt gctgagggta gattattgtc cgatagcaag
      661 gcagaaaatt tgaagtggct tgcggggctt ggatttgatg tggttgacca taagattgtg
      721 accgctgaaa ctgtagagca ggaagtggaa tggtttcgtg cctatgtaaa aaagaatgac
      781 attgcatccg atggtttggt tttaaccttc gatagtattg attatagtga aaatcttggc
      841 agtacagcga aattccccaa agattccatt gcctttaaat gggcggatga aatggcagag
      901 actaccttgc gggaaattga atggaatacc tcaagaactg gtttgatgaa ccccattgca
      961 atctttgatc ctgtggaatt ggagggatct agagtcagca gagccagtgt gcataacgtt
     1021 agtattttgc gggagctcaa gctgggtatt ggtgatagta tcaaagttta taaagcaaat
     1081 atgattatcc cccaaattgc agagaatttg acgtgctctg actcagctga aattccaaag
     1141 gagtgctttg tgtgcggtgg ggagacccaa atcaaaaaac aacgagacgg ggaagcttta
     1201 tactgcacaa acccagagtg ttctgcccaa agaattcaga gacttactca ttttgtgtca
     1261 agagatgcca tgaatatgga gggcttttct gaggagacca taaagaagtt tctggagatg
     1321 ggctttattc agcaatatcc tgatattttt tgtttggaga aatatgaagg acaaataaaa
     1381 aaaatggaag gcttcgggga aaaatcttat agtaatttga taaagtccat tgaaaaggca
     1441 aaacaagtgg agcttccgaa ttttatttat gctttaggca ttgatcaggt gggcttgcgc
     1501 aatgccaagc ttttatgtag taaatatcat tatgatttgg ataaaattat tcacgcttca
     1561 gaagatgagt tgattggtat tgatggattc ggaactgtaa tagcccatag cattcatcat
     1621 tattttggag aagaagaaca taaaacactg ttaaattgtg ctttgaagta tttgaaaata
     1681 aaggttccgg tagaaattaa aacggaggga tctcttgtac aagggttaac ttttgtagtg
     1741 acaggagact tagaaaggtt ttcaaaccga aaagctcttt cagaggcaat agagttactg
     1801 ggaggaaagg taacaggaag tgttacgaag aagacgaatt atttaattaa taatgacgtt
     1861 ttctcagcat cttcaaaaaa tgaaaaagcc aaacaattgg gaattccgat tattagcgag
     1921 aatgatttta tacttcaatt taagataatg ccagatgaat ctaaaaacat ttaaacaaat
     1981 ctaatataga cgagatagga atcttaaacc attgtagagt agattggcgg gtgcttttat
     2041 gtacctgtct ttttattatt tttgatagac cttaataaaa cgagcataat tttgttaatc
     2101 agatagatga tgtattagaa gtggcaatag tgaaatcgag tttgatattt gcaaaaaagt
     2161 ttctcctttg aatgtttaag aatttttaca gtcaaaggag atttttttat tgctgccatt
     2221 ttaaacactt tttttcaagc aaagcgatac cctcatacat aagggcggca agaatagcaa
     2281 gtataatgac actgagcatt acccagtcta gtttgaatat ctgacttccg tatacaatta
     2341 aaaatcctaa tccggattgg gcaaccaaaa attctccgac aataacacct acaaaagata
     2401 accccacatt aattttcagt gcgtttaaga tacaagggat gttcgctgga aaaacaactt
     2461 tttttagcac ctgtgctttt gtgccgccaa aaatttgtat cagctttatt ttttcagcat
     2521 ccacttgcaa aaaaccattc aggacactca ttactgtaac aatgactgaa gttaacaaag
     2581 caaccgctat aatggaagtt tggttatttc ctaaccaaac gataataatt ggagcaaggg
     2641 cggttttggg taaggagttt aatactacca aatatggctc tgcaatatcc gaaataaaac
     2701 gattccacca taatagaatt gcagtcaaag tgccgaggat tgttcccagt acaaaaccag
     2761 ctacagtttc ccaaagggtt gttccaatgt gagtccataa tgtgccgtct tttcccattt
     2821 gcattccagc tgatagcatt ctgcttggct gactaaaaat gaacggatca atccagccaa
     2881 cacgagctgc aatttcccat agtagaaaaa aaccaatcag aagaatccat tgaatgccat
     2941 gtatagcatt ttttcttcgc tgtaagcgat ttaaaaaagc tgcctgctcc tttgacatga
     3001 attttgtatc cttttgctta tgccacatga acatctaact ccttccaaat tgcattgaaa
     3061 tattcccgaa attcgggtgc ttctctagcc tttatgggac tatattcatc aattgacagt
     3121 tgaatatcat aaatcctttt tacttgtgca gggcgagaag aaagaacaac gactctatct
     3181 gcaaggctga ttgcttcaga aatatcatgg ctgactaaaa ttgcagtttt cccttctttg
     3241 cgtatgatag acccgatttc atcggaaacg gaaaggcgcg tctgataatc taaggcggaa
     3301 aatggttcat caagcagcag tatatcaggt cgtatggcca atgtacgaat gagggcgacc
     3361 cgttgtcgca tccctccaga aagctgatag ggataatgct ctttaaaatc agcaagaccg
     3421 tattgatcaa gcaatgcttc aacaaaagca atattttcgg aagtaagctt attttgtatt
     3481 tccaagccca gtagggcgtt attgcgtatg gtacgccatt ccaaaagata atccttttgc
     3541 agcatataac caatttctcc gttcacagaa atttttccgt gggaaggtgt gattagtcct
     3601 gccaacatgg aaagcaggga ggatttaccg catccactgg ggccgacaat actgagaaat
     3661 tcaccagcct gaacggagag atttaaatta gaaacagcca atgtttcgcc attcacacta
     3721 tgataacgta ggctgacatc ttctaaagaa acgatagggt gcatggaaac gacctccttg
     3781 ttgacttata ttcccattat atcaattaca ggacaaaaag tgcttttcct atttaaagaa
     3841 tatacagaaa agcaaataca ttttttaagg attataaagc gttcacaaca acatcgtttg
     3901 atcaaaatgc aaaagcccgt attgcaagga aattttagga gattttccaa ttgcaatcgg
     3961 gctttttatt gaaaaatgat aaagactctg aaaaatacag aaaacttcac tttcataata
     4021 cagaggataa cactcttact aaaatttact ggctattctt attttctaat aaattattta
     4081 atcctcttcc atttcccaat aatcatactc tgatgcaaga acattttgct ctctacgagg
     4141 tctgcagctt tgccacaacc agtattgctg ccaccaccaa tatttgcagg aacagtggca
     4201 gccacaacaa gaatgtctgc accgtctgtg acttgatctt cgttgatcac acatgatata
     4261 tcctcctttc cgtttgatta catagtttta gcatctgtta catctacaac agcaacgatt
     4321 gcatctgcag caccgacagc ctctgtggca gcaacctcta caacatctgt gacatgtttg
     4381 tccaatcata ttttatcctc ctttcttttt tgagagaaat gggtggttgt ttctctttct
     4441 ataaaatatg aaagaaggga caaattggtg aatgcataat aatttaaaaa acaataagag
     4501 gggaagaaat acctttataa acattaattt cattagactg ttaccaagta atttggtttt
     4561 atatactttt caaagaccac cttttttgtt ttgtggagcg atatatatag aaaaaatttg
     4621 gaaaatttga tataattaat aaattaaaaa atatttatgt ttcacatagg tgtttcgtat
     4681 ttcgtttaag gctttataaa cctaggaaca atggtaatag aaattttact ttattatgtg
     4741 caccttttat acgcaaggtt ttctgctcca ctgttcaata atcattaaca atgaatcaat
     4801 tcactttaaa ttactttttc tgaacaaaac acaaagtgtg aaatacctgc ttataagatt
     4861 taaggcccta gtagttgagt attcgttaag gatacatttt tgttacttat atttgagaga
     4921 caacctgtga tagcacttaa gtttggggat aaactttttg tgtatgaagg atagcttata
     4981 ttgaaaataa atggattatt ttctttccca gtgagggata aaaggatggg atgtaagatg
     5041 gacagtgaaa ttctgaaaag ctctggcatt gattttgata aaggtgttgc ccgttttctt
     5101 ggtgacaggc agctatatga aagcatatta attacctttt tgtatgatga tacattcgag
     5161 aagggaaaag cagcactgga aacagaaaat tataaaaact tatatgaatt tgttcatacg
     5221 ctaaaagggg ttgcaggtaa tacagatatg accactttgt atctaactac agcagtatta
     5281 agtgagtatc tgcgaaaatg tgaggttcct gaaaaagata gagtttttca tcttttttgt
     5341 ggaatggaag aggcatatta tgctgtaatg aaaggcattg cagccgcaaa ggaggcatga
     5401 tgaatcaatg gatgcagata ttggtaaaaa gacaattcta attgctgatg atgctgagcc
     5461 aaatcgctta ttgctgaaaa aaatatttgg cggagaatat tatgtggaag aggccgtaaa
     5521 tggagttgag gccttggaga agttgcggca gttagaagat gttgcgatat taatattgga
     5581 tattgtgatg ccgttgatgg atggatttag cgtgcttgaa gagatgcaga aggatgaaat
     5641 attacgtacc attcctacgg ttgtgattac tgctaataac gaagaagata tccaaattcg
     5701 agcattatcc tgcggtgcta ctgatgttat ggccaaacct tttagtcctc tcattatcct
     5761 acatcgtatt aaaaatataa tggctcgtaa agattctgaa aaacttgcgg agcagaaccg
     5821 agcttataga cttgaactga aacttatgga taccgatgag aaatcgggat tgtttaataa
     5881 aaatgcattt catcgatata caaaaaagat gctccagaaa aattcagaca aaaagtttgt
     5941 tttaatccgc tgggacatcg ataattttaa ggtgtttaac gattggtttg gaactgaagt
     6001 tggagatact tatttgaaga aaatcgggga tttttttcgg gaatacgaag aaaagaacga
     6061 ttcagtcaag acctatgcca gatatgatgc agatcatttt gtttgctgcc aagaggctga
     6121 ggggtttgat ccagaggaaa ttacacaaat cattgatgac tatatgaccc atttaaaaac
     6181 aattgaattt gagtataccc ctcgtgttgg actttatctg attaacgatc catccctgga
     6241 tgtggcgtta atgtgcgaca gggctttact tgctttacgt tcaattaaag atagttatgg
     6301 aaagcgctat gcatggtttg atgattctat gagagaggcg ctattagaac aacaagaaat
     6361 tgtaaacgaa atggaatttg ctctgcgaga tggacagttt attacatatt ttcaaccgca
     6421 atataattac gaaacaggta aaatgattgg ggcagaagct ttggttcgtt ggcagcatcc
     6481 aagaaaagga acaattttgc caaataagtt tatcccactg tttgaacgta atggatttat
     6541 ctctaggttg gacgagtata tgtgggagca ggtttgtatt caattaaagg attgggagcg
     6601 gaaagggctg aacttggttc ctatttccgt aaatgtatcc cgcagagata tttataatcc
     6661 ccacctagtt gggaatattc tctccctgct tcaagaatat gaattaagtc ctgaaatgct
     6721 tcatttagaa ataacggaaa gtgcctatac gcaaaatgca gagcagctgg ttaatacagt
     6781 aaatcttcta agaatacatg gaatagaagt acatatggac gattttggta gtggatattc
     6841 atccttaaac atgcttcaga acgttccggt agatatcttg aagctggata tgagattttt
     6901 agggggagat tataaggatg aaagaagtgg aaatatttta aatgcagttg ttcgtatggc
     6961 aacagcatta aggctccctg tgctagcaga gggtgtagaa acgaaggaac aggcagagtt
     7021 tttaaggagt attggatgtt tgctaatgca gggatactta ttctcaagac caatggcagt
     7081 tgaggatttc gagaagcttt tagatggttc ccaaacagtt tcagcattgg ataaaagtta
     7141 tgtagagagc tttcaaggtt caattgattt gttaagtttt acatctcaat ccactttatt
     7201 atttaactgc tttgttggcg gagcagcggt agtagaatat gacgaaaaag atgaagtatt
     7261 attagcctta aggattaatg accaatttct gagggaaatc ggtataacca gaatggaata
     7321 cgcggaggat gggcaaagta tctttcgtta ttatgaaggt gaaaataggg tactggtaat
     7381 ttctatgtta caagaggcca ttcatacggg aaaagaaaca tgttgtgaaa taatgagaaa
     7441 atccaaactg catgatatgg aagataactg gtttaaactt cgggcaagac tcctcaagaa
     7501 tagcatgagc aagcattttt tctatgtaac catggaaaat attacaatat ataaagagca
     7561 aaccgtagaa aatgaaaaat tagtgcattg tctgagcgca ctaacgaatc atgtggatga
     7621 agggcttttg gtgcttgaac tttctgagaa tataaaaatc caatattcaa atgtgagaat
     7681 agctgaaatg tttggttata cacaaaaaga atttcaggag ctttttggta atgattttct
     7741 tctgtccatt catcccgatg acaaggtact ggcgagggaa aattttgagc aaatattaag
     7801 ggccggtaat ggggtaggaa ggagaattta tcgacagact tgcaaaaacg gttattatga
     7861 gtgggttagc atgactggtt gtgtcgttga aacagagaaa gatcatattt gcatctgtac
     7921 caccattgaa aaagatgatg aaaataaaca aaggtattaa aataatttgt tttatagtaa
     7981 agggaaattt aaatcaagta ttagtctttg agacagataa caaaataata taatgttgcc
     8041 aaaaggagtt ttaaagtatt ctattataat aaggtaagca ttcattgagt cagtgccatt
     8101 taggtgctga cttttatctt ttggttatta tttgtaaagt aaaaaaagtg agttagttca
     8161 tttgatgaag gaaaaagtag acgatgaaga tactatgtta cagttttcat taaaattaag
     8221 taaatctata ccctcttttg attttttata ttaagggtaa acttattaaa taaatgaata
     8281 attgttttat gatttttttt gctcaaaact atgaataaaa tattgttgtg agttaccaaa
     8341 aaagaaatga aactgaaatt atactttttt tcagttgtca attttgtaaa aaacagtgca
     8401 aattttggca ttttgtaaat ttgggctaaa aaagtggtat tcttttcttg tacaaattat
     8461 tccaactatt cttaaagaaa tggggtgttt tttttatgaa aaaaggaaca aataaagtgt
     8521 gtacggaact atggaaggtg attgcctcat tggcgatggt gattacaaca atatcggtta
     8581 atacaacctg tatgtttgaa tattaccaac ccaaactacc tcaaggaagt gaaaagttga
     8641 gaagagaata agattaatat taaatttaat ggtgtactgt tcggggtgat tgcacatgac
     8701 tgagaaactg atggatggaa tttggaaaca aatgcagcta tcaaaaggac tgcaggaaga
     8761 cgataaggat atttatttat tcggcgttta ccagggtgca attttactgt tgaatatttg
     8821 tacagctctg ctcattgggg tcgccctgaa catgcttctt gaaatagtta tttacttgat
     8881 ttgctttctt ccactacgca tttttgctgg aggttatcac gctaagacac agcttaggtg
     8941 ctatatcatg tcaagtttta caacagtaat tattttgttg ggaattcaat ttttacagca
     9001 acaagaaagt atatgggagt tcttaagtta tattgtttct tttggaatta tttggagatt
     9061 tgctccggtg gcagatgcga ataagccttt gctggagaag gagcatgtga tttatcaaaa
     9121 aaaggttcgt aaagtactat tgcttctaac agggattgct gcgttgacat attttttagg
     9181 ttttaacatt atcagcacag taatagaagt atcagtatgt tttctttcgg tcattttact
     9241 tatgggaatt tataaaaaca aagtacattg taataacata gaagaattgg aatgtaataa
     9301 ataagaataa gactgctatt tataattata atctaaagtg caggcacatc gggggatagt
     9361 tgtttgtttg ggtttagttt aaagtagtat gagtaacagg tagagactta aatggcacta
     9421 agaaagcctt tgaaaaaaac tggcacagct ctatcactag gtctgtacca gctttaaaac
     9481 gatactatag ggtggcatct actatcaaca gatattgtat aaacttggtt tttaacattt
     9541 catatcttta tttttgatgg aaaaaataga tatgtctata catacataac tatttctaca
     9601 tcaaaatagt tttcttcagt gagaatggtt aaaacaccac tgtatttttc gacaattctt
     9661 tttacgttgc ttaaaccgat accgtggggc tcattggaat ctttttttgt gctgaaaaaa
     9721 gtatttcctt tctttttgat ttccccaagg aatgagtttc taatatgtaa taaaatggtt
     9781 cctctatcat acacaaagtc cattcggaaa aatccatttt cctgttcttg tagtgctcta
     9841 attgcattat caagtaaatt tcctaatata acaatttcat caaaagcatg aatattaata
     9901 ttttgcggta tattgatatt tagctctact tttacgccta aatcatatag agtttgtagc
     9961 ttatagttaa ttaaaccatc tagagattca tttcctgtca ttacaaattc ggatttcata
    10021 tcaatttttt cttctaatgc ttgaaaatac tccttaaagt tttctgtatt acaatttgat
    10081 gacaattctt ttattgcaat caaatgattc ttgaaatcat gttgcaacct tttcatgttg
    10141 tcttctgcgg tacgaatcac gacaagttgc tgctggtaag ctttattttg gtgtgataag
    10201 gactgatttt gcatctccac ttcatacttt tccactactt gtgcgtatag gtagaaaaaa
    10261 gctatattaa tgatgaatag gcttgaaata acggtaacgt ttacccattg ttcatatcca
    10321 cccaaaataa gagaaatatc tgctattgat gatatacatg gaataatagt aatacaaagc
    10381 caatgtaatt taggaaggta aatatcttcc cgttctatga agaatcgtct cataattaaa
    10441 ataataaaat acaacaaaaa attactaacc acatatgtaa taatttcaat cttagggcac
    10501 aagccatata gtagaattgc agttcttgct acgattccct cacaaattac accaatcata
    10561 aaaatggagc aggttgcaaa taatctacgg ccgatggatg ccctataggg gagagtcaac
    10621 actacaaata aaactgcatt cgtaatgact gttaaaacag gatttcgtgc gaataaataa
    10681 actccactat tgataataaa ataaagaaat aataccgctg tttgggtcca tggctgccat
    10741 ctcaggtttt ttttgaagaa gaaaaactct agaaatagtt taatagcaaa gatacgaaaa
    10801 gcattcgaaa ttaaataaat cacttcatta taggaaattg cttccatttt acaaaacctc
    10861 tctttgtagt aaatttaatt gttttcttac ttctttccga taaatacggc tgatgggcaa
    10921 ttcttgggaa ttactcaata aaaccctgtc aaatttgaat tgaattacac aatgcctatt
    10981 tacaataaaa gatttgtgga tacataaaaa gtcttctgat ggtacgatta agtcgctcaa
    11041 ttttccataa aagtagtcct ttccattttt catatgtaaa aatatttttt tgccttcact
    11101 actaaaataa agaatatctc taaaagatac tcttttttct gttctctcac ttttgtaaca
    11161 gaagaatttt gtttgtcgac cctgtagttc caaggttttt tctattattt taaaaatttg
    11221 gtcttttgct atgggtttta tcaaaaagtg aataggtcga acttgaaaaa gatccaaagc
    11281 gtaagatgat ttagcagaaa taaaagcaat ttgtgtgttg tcatctaaca attcttctcg
    11341 aatataacgt ccaacatgaa tgccatttat cctatctaat tcaatatcaa gaaaaattaa
    11401 gtcatatttc tccttttctt ttaagtttgt gagtatttct tctccggtaa aaaacacttc
    11461 aatatcataa tttatcattt ctgttgaaaa aaactcatca atctgctttt caatttgagt
    11521 acataatatt ttgttatcat cacaaatagc aattttaaac atctcagcca tcccacctaa
    11581 aaatctgaaa atttaatatt aatatattac cataatttta ataattttaa aatcagataa
    11641 ttatttttcg aattacaaca ttcaaagaac tttaattaag ttgttgagac ttttttaagt
    11701 ccggttttaa atattagtga tgaaaataat tagtatgtca caattgtaaa tctatgaaag
    11761 tttgaaaaag cgtatataac tgagttttat aaaggtctca gttaatacgc tttttttaag
    11821 ctaagaaaaa atgcctataa aaacgcagta taaataatac tgtggtgagg aattttgcca
    11881 tattttgtca tgttatatta tatatctaat gtttgtttat tgtcaatcat cacgttacaa
    11941 caataaaaaa ccttaaatta taagttttta tgataatttt ctttgattta tgtgaaatat
    12001 ttcctttata ttgtgattac gccgtcggaa caaacgtcat ataaatagaa agagttttct
    12061 atcattgaaa catactgtca cttaagaaac ttaggtgttt cgtataaatc cttaatatta
    12121 aaaattaaat taagaaataa ttagcttaaa aattctattg taccatacca aaataaatcg
    12181 tctttttttt gtcttatatt atttcaatcc ttttaagaac aaggtttttt acgacttacc
    12241 acagtattat ttatactgcg tttttaaaaa gagtatttat gtattcaagt atctcatggg
    12301 aggcagatat cctatgatga gaacataatg ctttttcaaa catacactat agaaattcta
    12361 agtatatgat cgtaaaacta agttagaacc attacttttg gaaggaggat atatgacaaa
    12421 aatgaatctc gatataaaaa gagtagagaa tttctttgtt tatgtattag tgaaatctaa
    12481 tgtaaagaat tgtaagccga ttatttttag tgagaataaa agaaagaggg atatggaatg
    12541 aagcagtggt ttgaaaatgc gaaagtatcg aaaaagttga gcatcgggtt tcttcttaca
    12601 gtgtttttag ggcttattat tggcattgtt ggaatcggaa acatgcttaa catgctcagc
    12661 cgccaacaaa aaacttacga tcagaataca ttgggaattg cctattccac ggaggcagaa
    12721 attagtttta aagatgttag gacttccata agagatcttt atatttacta cgatataaat
    12781 aaacagaaat actgtaatgc gattacaaat gaaatgaatg atattcagac gcaattagat
    12841 cactatgcaa gtagaattgc taatgagcag gatcaacaga attttgatgt agctcagcag
    12901 gcatttaaaa actataaaaa tgttgtagat gaaattgtac aagctgctaa taatggagat
    12961 tctaaggatt ctatattggt attaattaaa gagggtgcat cagttgggaa tgatacatcc
    13021 aacgcattta atacacttac agaatataat aatttggcag caaaagaaaa tttggacaat
    13081 gaaaaaacta catcttggat tgcaattatt ttgatggctg tgacgattgt gatatctgtg
    13141 attatagcaa ttcttatgag caaatttata tccaatataa tcagcaggcc tatgcagatg
    13201 ctggttatgg tagctgagca tttagaaata ggagatgttg atgtttacaa tttaatgtct
    13261 gaagaggata aaaaggtaaa ataccgaaaa gatgaaattg gtaaggttgc attagctttt
    13321 aataaattaa ttcaggcaaa tattgcgtta agtaaagagg cagaaacggt tgccacaggt
    13381 gacttgacca caaccgtaac ggttcgctgc gaaaaagata ttattggcaa agcgttgcga
    13441 gatttagttg agaaacttca tagcctaatt tcatctgtag cgattacttc cgaacaggtt
    13501 gactttggtg caaggcaggt ttctgatgga gcacaagcct tgtctgccgg caccacagaa
    13561 caagcagcat cgttagagga gttgacttct gcggttgcta atatttctga gcaggctgta
    13621 aataatgctg ccagtgtgca aaaagcgggt gagtatgtaa atcaggctgg taaaggtgtt
    13681 gtttccagta gtgaacagat ggagaagttg aaccatgcta tgaaggagat tgggcagtct
    13741 tctttgcaaa tttctaagat tacaaaattg gtagaggata tagcatttca gacaaatatt
    13801 cttgcattga atgctgcggt agaagctgct cgggcaggaa atgcgggcaa aggttttgct
    13861 gttgtagcgg atgaagtccg caatcttgcg gcgaagtcgg ctgaagcagc gaaacagaca
    13921 gcagatttga ttcagagatc tacaatattg gtatccgaag gggaagtact tgcggataaa
    13981 actgtgcaac ttttaatcga tgtctcagaa aaagctgcta tggtagaaaa ctctataatt
    14041 gaaatagagt ctgcttcatc atctcaggca actgcaattg agcagattaa ccagggactc
    14101 tctcaggtat cggccgttat tcagacaaat gcagcaactt cggaagagag ctccgctgcc
    14161 agtgaagagc ttgcggcaca ggcacaagtt ttgaagcaag agattaccca ctttaaatta
    14221 accagagaga aagaaaacta cagcataaga gaaaatgaaa ccgctttctc cgaaaatcag
    14281 ggtgaacaaa ctgtttattt gaacccctca atcaatgact atgtaaaata ttaaaaattg
    14341 tggtgtcaaa tctaaagtta gagtcttgaa cgaaacgagg aaaaagaggg acagaaatat
    14401 cttttagcaa atcaaatgaa aataacaaag ctgatttgat ggaataggtt aatcatttat
    14461 ttaaaagcct tgatgaagat ttaaaaatag tgagcgttaa aacgcccctt tacagtttgt
    14521 aaaggggcgt tcagtttaac attgaaaaat agaattaaac cgcagtatac ttgatactgt
    14581 gcaactgcaa ttaagtataa tataatacaa tttattatat aacaactgct ttcagtttgt
    14641 caattcgtgc gacatttttg tcgaaaaatc acgaaaacaa aaataataat ttgtattttg
    14701 attattacat ggtgcttttt cagtgcaatt acaagtttcg ccgtcaagag cgacgtcatg
    14761 gaagcaataa atttaatcaa ggaaaaggag aatgacaatg gcacgtagag gagaaaacat
    14821 ttataaacga aaggatagtc gctgggaggc aagattgctt atccagaagg gaaagtatag
    14881 atacttttac ggtaaaactt ataaagaggc aaagttaaaa atgcgcttgt ttcaagaaaa
    14941 tataaaaatt cataaagaga aacaagctga acagaaaaca aatgcatatg tgttgtttga
    15001 ggggtggctt caaaaacagg tgaccttaaa caatgtaaaa ccattaactt atgaaagtta
    15061 ttaccattgt atgcacaagc atatcatgcc attttttcaa aatgagcaaa caaatagaat
    15121 cacaatagaa actgtttcgc aatttacgaa aactgtcagt gagaatgaat tacttgcgga
    15181 cacctcaaag aaaaaaatat tcaccatttt taaaattgct ttgagagaaa ttttaaaaga
    15241 cgagctaaac agcgcctcta ttctggcagc tgtaaaatct ccaaaactgg agacaagaga
    15301 ggttgaaatt ttttcgataa aagaacaacg gagcttggaa gcggctgcac tacagtcaca
    15361 ggatcaacgt gccttaggca ttattttatg cctatatacc ggtatcagac tgggggagct
    15421 ttgtgctcta acgtgggggg acattgattg ggatagtggg tttatgtcaa ttacaaaaac
    15481 agtatcaaga gtgaaaacct ttaagcagga tacaaaaaag actgaattga tagtaggaac
    15541 ccctaaaagt cgtaattcaa tgcgtaagat tcctgtgccg gaatttctgt taaaattagt
    15601 tcggcatcgg aaactatggg aagaaaatga agatgctttt gttctttctg gtaaagaaac
    15661 tccaattgat cccagaatat ttcaaaaact gtataaaaaa ttactggtgg acgcacattt
    15721 gagagatcgt aaatttcacg ctatacgaca cacttttgct acgcgaggat tagaattagg
    15781 tgtagatatt aaaacgatta gtgagatatt aggacattct aacgtttcta taaccctgaa
    15841 tatatatgcc cattctttaa tagagcagaa aaaggctgca atggaaaaat ataatgccat
    15901 gcatattgca tcggctgaaa tctctaaata cgccgtctaa aacatagtgt ataataaaaa
    15961 aaggccctga aattggatgt tttatgttta gggcgcagta tcaagtatac tgcgttcttg
    16021 aagtctaaat aaatatcccc catacgaatt gatttatgtg ctttttttat gttacttcca
    16081 atgatgataa ttggataaaa tcacttttga aagatttatt ttaccgcaaa tgaatatgta
    16141 acgtaatatt ttttgcaaat ttatatctta aaattcggaa cttatctatt ctgttaaatt
    16201 acaccataag aatgtatcac aataaagcct taggtctatt ttacagacga taaatattca
    16261 agaaatgggt tcattctttt gaagataaac tcataattgg ataatctatt ttagtgaaac
    16321 tataaaaggt aagaagatta taaggaagag ataaatcaaa atcataaata tggcctaaag
    16381 agaaaaaagc gtaaaggggg acgtaatttt gtttgaattt tttcaaggtt taacagcaga
    16441 tgaattgatt catatgctgc ctgaagatca aattaggcac agcttaaatg tagaaatact
    16501 tgttgggaag ctagtagaat ggttgccaaa gcctgaggaa gtacaattgt ttgaatatta
    16561 cagtagagct gcctattacc atgacatagg gaaggtttgt gtccctcctt atatactgaa
    16621 taaaacaggg gcgttaacgg tggaagaacg ctatattatt cgatgccaca caatctacgc
    16681 ccaggacttg cttgcttttt acagggagag tggttcggga gaaattcctt tatttcttct
    16741 tcctctcact gtacaggcgg ctgtttatca tcatgaatgg tggaatggga agggatatcc
    16801 ctatgggtta agcggtgcag atattccata tgtggcacga ctaacttcca tatgtgatgc
    16861 atatgatgca atggtaagca atcgcccata tcatctggca tttacccatg agtacgcatg
    16921 tgaagagatt aggaggggtg ctggcaccca gttcgaccca gtgcttgcaa aggtgttttt
    16981 aaagcataaa aaagaaattg cacgcattat taatgaaatt tgcacatatc caacggacaa
    17041 gcttgaattt gaaataaaac gacttttaat taccaagcag aattaaattt tattttcact
    17101 gaggccatat cttttgatta aagaggacgt ggtctttttt tatacttcaa gaattatagt
    17161 aatatagtaa gggtcttgaa actcaataaa ttagaaggac ttatttataa tccgtaattt
    17221 taatatattg acgacatagt tatagaggtt gcaataaaat actcaatttg aaaaccagga
    17281 ttaaatgatg gtaaggtatt gtaaaagatc tgagtttccc tgtatgaatc ataacagatt
    17341 aaaaaaaatg aaagaagaat ttatctctag gatagggtca tatgagcaaa tcgaaagatt
    17401 ttttaaaatg ccgaatcttc cacgagttaa aacatttaga ttaggtaata agagagtaga
    17461 aatcatttga atacaggcaa tgctaatttt cataaaagat ataaatttat tacaacaaac
    17521 atgtaatatt caaagaaaat agctatggat gctaagattt cagtgaggat tttgagggta
    17581 tcttttttta aaagcatggt atgctttctt ttttgaaatt gttcatttta ttgcaaataa
    17641 atttaaaatg cttacaaaag taggacgcta gtcattacga ctagcgcccg ttcatcttaa
    17701 gctaaatctg cttgttcatt ttttgatgca agaagagctt tttcggacat tgggataaat
    17761 ttacctataa taccgccaat gattgcagga ataacccatc cacactggaa tgttgcaaga
    17821 ggaagattct taacaaattc aaaaggtaat ccataaccta ttgatacatc agcagcactt
    17881 gccaataaag ccagagccgc agcaccaata tagatgttat tgtttttaat tttatttgca
    17941 aagaagctta agataatcat aacaagaatt actgggtaca atagagttaa aattggccct
    18001 gcaatgctga tgatagtgga aatgccaaag tttgaaataa agtagctgaa aataatttca
    18061 atgacaataa tttttgtata ggaaatctta ttgttagtca tctcaacaaa aacggatgca
    18121 caagaagata ccaagccgat tgctgtggtc atgcaagcaa agaaaacaat gattcccaaa
    18181 attaagatac catagctgcc aatcagtttt tgggtaatag ctacaagcag tatagactga
    18241 ttatagtttt caaagccgcc tgcagatgtt gtagcaccta agtaacacaa accgccataa
    18301 acgataaaca aagcaacggc agcaaaaaag ctggattgag tgataatctt tacagttgac
    18361 tttttttctg aatagccctt gctttgcgct gtagtaacaa tagtgataat gaatacgata
    18421 gatactaaaa catccattgt ctggtatcct gcaagaacgc cttcttttgc agtatcaaaa
    18481 ttggttgtag ctacaatgtc accaattgga tgtaaatagc cgattacaat taatcccaaa
    18541 agacaggcaa ccaatgcagg tgtaaagaat ttaccaatta cgtcgattac gccagatgga
    18601 cggattgtaa agagaagtac caagccaaaa aagattgcgc caaataccca agagttaata
    18661 gaagggaaaa ttggcataac gcccatttca aaagtggttg ctgctgtacg agggatacat
    18721 aaaaagggcc cgatacataa aacaattaaa atattcatga tgaatgaagg cgctttaccc
    18781 aatttacccg tgagaccatt tattgaaata tcacccgttt taatcattgc aaagattgct
    18841 gctaatgcca cccctacgtc agcaacaaag aaacataaaa agccgataaa ccaatcacta
    18901 cctgcattta tccctaagta tggggggaaa atcaggttgc ctgcaccaaa gaacgttgca
    18961 aataatgcca taccgattac tgcaatgtca ccgatgcctt ttttcttttc tttcat
//
