GCF_900460525.1_28863_B01_genomic - 5 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_UHIY01000001 (original name was: NZ_UHIY01000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	betalactone	543,503	569,249
Region 3.2	NRPS	1,926,914	1,974,113	turnerbactin	NRP	38%
Region 3.3	transAT-PKS,T1PKS	3,008,792	3,065,508	oocydin A	NRP + Polyketide	13%
Region 3.4	thiopeptide	4,197,509	4,223,932	K53 capsular polysaccharide	Saccharide	10%
Region 3.5	NRPS-like	4,592,197	4,635,217

Region	Type	From	To	Most similar known cluster	Similarity
Region 3.1	betalactone	543,503	569,249
Region 3.2	NRPS	1,926,914	1,974,113	turnerbactin	NRP	38%
Region 3.3	transAT-PKS,T1PKS	3,008,792	3,065,508	oocydin A	NRP + Polyketide	13%
Region 3.4	thiopeptide	4,197,509	4,223,932	K53 capsular polysaccharide	Saccharide	10%
Region 3.5	NRPS-like	4,592,197	4,635,217

No secondary metabolite regions were found in these records:: NZ_UHIY01000002 (original name was: NZ_UHIY01000002.1); NZ_UHIY01000003 (original name was: NZ_UHIY01000003.1)

Compact view

c00003_NZ_UHIY.. - Region 1 - betalactone

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Location: 543,503 - 569,249 nt. (total: 25,747 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.24	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.21	Other	FR-900098	Streptomyces rubellomurinus
BGC0001294.1	0.17	Other	7-prenylisatin	Streptomyces sp. MBT28
BGC0000375.1	0.15	NRP	indigoidine	Streptomyces chromofuscus
BGC0001441.1	0.15	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001641.1	0.14	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.14	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.14	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001150.1	0.13	Polyketide	pamamycin-607	Streptomyces alboniger
BGC0000597.1	0.13	RiPP	SWA-2138	Streptomyces sp. e14

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001859.1	0.57	Other (Phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.1	0.53	Other	FR-900098	Streptomyces rubellomurinus
BGC0001294.1	0.49	Other	7-prenylisatin	Streptomyces sp. MBT28
BGC0000375.1	0.46	NRP	indigoidine	Streptomyces chromofuscus
BGC0001441.1	0.45	Other	belactosin A, belactosin C	Streptomyces sp.
BGC0001641.1	0.43	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.1	0.43	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.1	0.43	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001150.1	0.42	Polyketide	pamamycin-607	Streptomyces alboniger
BGC0000597.1	0.42	RiPP	SWA-2138	Streptomyces sp. e14

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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c00003_NZ_UHIY.. - Region 2 - NRPS

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Location: 1,926,914 - 1,974,113 nt. (total: 47,200 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.39	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.35	NRP	paenibactin	Paenibacillus elgii B69
BGC0001615.1	0.33	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001399.1	0.31	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000457.1	0.29	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001149.1	0.29	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001833.1	0.27	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.27	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001873.1	0.27	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001825.1	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.1	0.71	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0000401.1	0.68	NRP	paenibactin	Paenibacillus elgii B69
BGC0001615.1	0.67	NRP	hexose-palythine-serine, hexose-shinorine	Heteroscytonema crispum UCFS10
BGC0001399.1	0.64	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000457.1	0.63	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001149.1	0.63	NRP, Saccharide	brabantamide A	Pseudomonas sp. SHC52
BGC0001833.1	0.61	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.1	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001873.1	0.60	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001825.1	0.59	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 2, location 1926913 - 1974113:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg3_1710

Search NORINE for peptide: strict or relaxed

AMP-binding (482..898): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DsWdmGfIDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 60% (weak)

AMP-binding (1563..1962): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 100% (strong)

ctg3_1718

Search NORINE for peptide: strict or relaxed

AMP-binding (31..446): dhb

NRPSPredictor2: dhb

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: dhb, sal
Small clusters prediction:: dhb, sal
Single AA prediction:: dhb

Stachelhaus prediction details:

Stachelhaus sequence:: PLPsQGVVNK
Nearest Stachelhaus code:: dhb
Stachelhaus code match:: 90% (moderate)

c00003_NZ_UHIY.. - Region 3 - T1PKS,transAT-PKS

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Location: 3,008,792 - 3,065,508 nt. (total: 56,717 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.57	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000205.1	0.50	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000228.1	0.42	Polyketide	granaticin	Streptomyces violaceoruber
BGC0001273.1	0.42	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001998.1	0.42	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001400.1	0.42	Polyketide	citreoviridin	Aspergillus terreus NIH2624
BGC0001275.1	0.42	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.1	0.41	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000043.1	0.40	Polyketide	curacin A	Moorea producens 19L
BGC0001244.1	0.40	Polyketide	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000228.1	0.58	Polyketide	granaticin	Streptomyces violaceoruber
BGC0000205.1	0.58	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000913.1	0.57	Other	MK-8	Enterobacter cloacae
BGC0001264.1	0.55	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001280.1	0.55	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001104.1	0.54	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001273.1	0.54	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001998.1	0.54	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0000225.1	0.54	Polyketide	frenolicin B	Streptomyces roseofulvus

Similar known gene clusters

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 3, location 3008791 - 3065508:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)
Non-colinear ordering:: ctg3_2636 + ctg3_2637 + ctg3_2639 + ctg3_2640

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 3008791 - 3058283:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)
Non-colinear ordering:: ctg3_2636 + ctg3_2637 + ctg3_2639 + ctg3_2640

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 3018329 - 3065508:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)
Non-colinear ordering:: ctg3_2636 + ctg3_2637 + ctg3_2639 + ctg3_2640

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg3_2636

PKS_AT (4..117): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.7
Propionyl-CoA: 21.7
Methoxymalonyl-CoA: 18.5
2-Methylbutyryl-CoA: 15.1
Methylmalonyl-CoA: 13.7
CHC-CoA: 13.3
inactive: 12.7
Isobutyryl-CoA: 11.8
Ethylmalonyl-CoA: 9.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg3_2637

PKS_AT (1..145): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 29.1
inactive: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg3_2640

PKS_AT (547..843): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 70.8%; Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 110.6
Methoxymalonyl-CoA: 105.6
Ethylmalonyl-CoA: 97.4
Malonyl-CoA: 76.8
Isobutyryl-CoA: 68.6
Propionyl-CoA: 54.1
2-Methylbutyryl-CoA: 53.8
CHC-CoA: 51.0
Benzoyl-CoA: 49.6
trans-1,2-CPDA: 48.5
Acetyl-CoA: 38.5
inactive: 34.8
fatty_acid: 24.8
3-Methylbutyryl-CoA: 24.1

c00003_NZ_UHIY.. - Region 4 - thiopeptide

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Location: 4,197,509 - 4,223,932 nt. (total: 26,424 nt) Show pHMM detection rules used

thiopeptide: ((YcaO or TIGR03882) and ((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or PF07366 or PF06968 or PF04055) or thiostrepton)

Legend:

core biosynthetic genes

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MIBiG comparison

KnownClusterBlast

Thiopeptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000758.1	0.21	Saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0000732.1	0.20	Saccharide	capsular polysaccharide	Raoultella planticola
BGC0000749.1	0.20	Saccharide	capsular polysaccharide	Escherichia coli
BGC0000730.1	0.20	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000733.1	0.20	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000731.1	0.20	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000728.1	0.20	Saccharide	capsular polysaccharide	Klebsiella pneumoniae subsp. ozaenae
BGC0000729.1	0.20	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000791.1	0.20	Saccharide	O-antigen	Cronobacter sakazakii
BGC0000788.1	0.19	Saccharide	O-antigen	Salmonella enterica subsp. salamae serovar Greenside

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000758.1	0.53	Saccharide	capsular polysaccharide	Staphylococcus aureus
BGC0000732.1	0.52	Saccharide	capsular polysaccharide	Raoultella planticola
BGC0000749.1	0.52	Saccharide	capsular polysaccharide	Escherichia coli
BGC0000730.1	0.52	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000733.1	0.52	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000731.1	0.52	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000728.1	0.52	Saccharide	capsular polysaccharide	Klebsiella pneumoniae subsp. ozaenae
BGC0000729.1	0.52	Saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000791.1	0.52	Saccharide	O-antigen	Cronobacter sakazakii
BGC0000788.1	0.52	Saccharide	O-antigen	Salmonella enterica subsp. salamae serovar Greenside

Similar known gene clusters

Thiopeptide predictions

No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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Thiopeptides

Core peptide predictions

No core peptides found.

c00003_NZ_UHIY.. - Region 5 - NRPS-like

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Location: 4,592,197 - 4,635,217 nt. (total: 43,021 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001168.1	0.33	NRP	livipeptin	Streptomyces lividans 1326
BGC0001516.1	0.32	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0001900.1	0.31	NRP	fragin	Burkholderia cenocepacia H111
BGC0001599.1	0.27	NRP	fragin	Burkholderia cenocepacia H111
BGC0001399.1	0.25	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000343.1	0.24	NRP	enterobactin	Pseudomonas sp. J465
BGC0001343.1	0.23	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.22	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001538.1	0.22	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000375.1	0.22	NRP	indigoidine	Streptomyces chromofuscus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001168.1	0.66	NRP	livipeptin	Streptomyces lividans 1326
BGC0001516.1	0.65	NRP	aspergillic acid	Aspergillus flavus NRRL3357
BGC0001900.1	0.65	NRP	fragin	Burkholderia cenocepacia H111
BGC0001599.1	0.60	NRP	fragin	Burkholderia cenocepacia H111
BGC0001399.1	0.59	NRP	fellutamide B	Aspergillus nidulans FGSC A4
BGC0000343.1	0.57	NRP	enterobactin	Pseudomonas sp. J465
BGC0001343.1	0.56	Polyketide	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0000410.1	0.55	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001538.1	0.55	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000375.1	0.55	NRP	indigoidine	Streptomyces chromofuscus

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 7, location 4592196 - 4635217:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg3_4108

Search NORINE for peptide: strict or relaxed

AMP-binding (18..415): X

NRPSPredictor2: val, leu, ile, abu, iva

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DglFLGCTiK
Nearest Stachelhaus code:: ile
Stachelhaus code match:: 70% (weak)

ctg3_4109

Search NORINE for peptide: strict or relaxed

AMP-binding (0..204): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: nF-tMGVtyK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 50% (weak)

ctg3_4110

Search NORINE for peptide: strict or relaxed

AMP-binding (24..219): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAL------K
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 40% (weak)