LOCUS       NC_016610.1            12160 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_016610.1 Tannerella forsythia 92A2, complete sequence.
ACCESSION   NC_016610
VERSION     NC_016610.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:07:40
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1361718
            Orig. end    :: 1373878
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12160
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1366718:1368878](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7160
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12160
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12160
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1325..1507
                     /locus_tag="ctg1_1131"
                     /transl_table=11
                     /translation="MKENVFNVCRRGTAKKNAMAQVPDGYLTALTNRELEMIEGGDWEY
                     IVVDGEIIRIYIPKN"
     CDS             1842..2006
                     /locus_tag="ctg1_1132"
                     /transl_table=11
                     /translation="MKEKRNESTYAVEVMSESEMTEVNGGRFVKWWMYLISPGGAFIAG
                     RFEDGLLGK"
     CDS             2020..2172
                     /locus_tag="ctg1_1133"
                     /transl_table=11
                     /translation="METKKEIMAEMPLSEMENVDGGVVITTLAAVCTVVWFAGEIAYQI
                     GKSMR"
     CDS             2184..2315
                     /locus_tag="ctg1_1134"
                     /transl_table=11
                     /translation="MKSLEGNRQSNAKQALTIMFYLSIVIYVAGQVAFQIGAAMAGG"
     CDS             2527..2655
                     /locus_tag="ctg1_1135"
                     /transl_table=11
                     /translation="MLFIASASCILVLAIRCKNKKIKYALLACSLVLLILSMLITL"
     CDS             2947..3078
                     /locus_tag="ctg1_1136"
                     /transl_table=11
                     /translation="MKRCIFNKESNADKALVILFCLSIIIYVAGEIAYQFGQALAAG"
     CDS             3163..3372
                     /locus_tag="ctg1_1137"
                     /transl_table=11
                     /translation="MERQLFNLIVLSLIIAADCLAIYDLLRYEKKRSVLYKVVMVCLIL
                     LLPLLGVSIYYAIKNRHLRRRCSV"
     PFAM_domain     3217..3336
                     /aSDomain="PLDc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13396.8"
                     /description="Phospholipase_D-nuclease N-terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1137_0107"
                     /evalue="3.80E-06"
                     /label="ctg1_1137"
                     /locus_tag="ctg1_1137"
                     /protein_end="58"
                     /protein_start="18"
                     /score="26.8"
                     /tool="antismash"
                     /translation="CLAIYDLLRYEKKRSVLYKVVMVCLILLLPLLGVSIYYAI"
     CDS             3449..3580
                     /locus_tag="ctg1_1138"
                     /transl_table=11
                     /translation="MKKTIWKTALITLGVWVLYDIIRNLPESVAAFKAGMDFCMNML"
     CDS             3829..4986
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 96.4; E-value:
                     2.8e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1139"
                     /transl_table=11
                     /translation="MLLPNEFIENSIETYIYKHTTTSQKIYWVVLAAVTVALASLPFIY
                     VDISVQGLGIIRPVAEKTEIKSPVTELVDSVYVREGEQVKKGDILLRFRTNSSDYKIAY
                     QSNRLSDYAEQLSDLTYLARGACPPSFQSPVRRQEYHYYIKRKNELETSLDQAEKEYLR
                     NKSLFEKKVIAEEEYDKYLYRYKSQQNELASLIENQMSTWQANLNALRNSHSEMHTSLK
                     QEIKDKEMYFVKSPVSGTLDQFSGIYRGSSIRAGESLAVISPDSTLYFEVYVTPRNIGY
                     LSLGMPVIVQVESFNYNEWGTVGGTVKDISSDFMTDKQGHSSYKVKCGMDRDYLQLKNG
                     RTGKLKKGMTVSAHFMITRRSLFDLLYQKMDDWVNPARYKQVSND"
     PFAM_domain     4012..4113
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1139_0108"
                     /evalue="1.80E-05"
                     /label="ctg1_1139"
                     /locus_tag="ctg1_1139"
                     /protein_end="95"
                     /protein_start="61"
                     /score="24.5"
                     /tool="antismash"
                     /translation="KTEIKSPVTELVDSVYVREGEQVKKGDILLRFRT"
     PFAM_domain     4525..4821
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1139_0109"
                     /evalue="7.60E-11"
                     /label="ctg1_1139"
                     /locus_tag="ctg1_1139"
                     /protein_end="331"
                     /protein_start="232"
                     /score="42.7"
                     /tool="antismash"
                     /translation="VKSPVSGTLDQFSGIYRGSSIRAGESLAVISPDSTLYFEVYVTPR
                     NIGYLSLGMPVIVQVESFNYNEWGTVGGTVKDISSDFMTDKQGHSSYKVKCGMD"
     CDS             5001..7160
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     245.5; E-value: 6.8e-75)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 330.1; E-value:
                     4.6e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1140"
                     /sec_met_domain="TIGR01193 (E-value: 8.3e-160, bitscore:
                     530.9, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-34, bitscore:
                     116.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRGIKVKQHDITDCGAACLASVCAYHGLRFPVSRIRQYAFTDKK
                     GTNVLGLTQAAHKLGLSAKGVRALPEALDIVPKPAIAHVIVKEQLQHYVVVYKVTKTHV
                     TYMDPGDGRMHQKTREEFNKEWTKVMVIMEPEESFRRGNEKKSIISQFIALLAPHKSVM
                     LQALFGALVYSILGLSTAIYVGKITDYVLVDKNLNLLHLMGIIMIAVLLLRTFIGAMKS
                     ILALKTGQRIDAALILGYYKHLLTLPQQFFDTMRVGEIISRVNDAVKIRSFINNVSLDL
                     AVNVMILFFTSCLMFVYSWKLAVVTLLSAPLFLLVFWGFNRLNRKYQRRIMESAADLES
                     QLVESINSISTIKRFGIEEYANLKTETRFVHLLKNTFRSIYGSIMAQGGIQFISTGVTI
                     AVLWTGSVLVIDQELTPGALMLFYSLVGYVLSPISSLITSNQTIQDALIAADRLFQIMD
                     LERESDNSQKIKLTPEMIGNISFENVAFRYGSRKKVFESLNLKIEKGKTTAVIGESGSG
                     KTTLISLMQHIYPIQDGQIRIGEFDIAQITNESLRRIVGTVPQQIELFAGSIAENIALG
                     DLYPDMERIIDLAEQLGLKEFIEKLPQNYMTYIGEHGASLSGGERQRLAIARALYKEPE
                     ILIFDEATSSLDSVSEKFVKQTLKSLATRGKTIIVIAHRLSTVRDADAIVVLDDGKVVQ
                     HGVHEQLIHEDGIYRKLWNEQYGMV"
     PFAM_domain     5019..5411
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1140_0110"
                     /evalue="7.30E-34"
                     /label="ctg1_1140"
                     /locus_tag="ctg1_1140"
                     /protein_end="137"
                     /protein_start="6"
                     /score="116.5"
                     /tool="antismash"
                     /translation="VKQHDITDCGAACLASVCAYHGLRFPVSRIRQYAFTDKKGTNVLG
                     LTQAAHKLGLSAKGVRALPEALDIVPKPAIAHVIVKEQLQHYVVVYKVTKTHVTYMDPG
                     DGRMHQKTREEFNKEWTKVMVIMEPEE"
     aSDomain        5025..7139
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1140_0022"
                     /evalue="1.30E-159"
                     /identifier="TIGR01193"
                     /label="ctg1_1140"
                     /locus_tag="ctg1_1140"
                     /protein_end="713"
                     /protein_start="8"
                     /score="530.9"
                     /tool="antismash"
                     /translation="QHDITDCGAACLASVCAYHGLRFPVSRIRQYAFTDKKGTNVLGLT
                     QAAHKLGLSAKGVRALPEALDIVPKPAIAHVIVKEQLQHYVVVYKVTKTHVTYMDPGDG
                     RMHQKTREEFNKEWTKVMVIMEPEESFRRGNEKKSIISQFIALLAPHKSVMLQALFGAL
                     VYSILGLSTAIYVGKITDYVLVDKNLNLLHLMGIIMIAVLLLRTFIGAMKSILALKTGQ
                     RIDAALILGYYKHLLTLPQQFFDTMRVGEIISRVNDAVKIRSFINNVSLDLAVNVMILF
                     FTSCLMFVYSWKLAVVTLLSAPLFLLVFWGFNRLNRKYQRRIMESAADLESQLVESINS
                     ISTIKRFGIEEYANLKTETRFVHLLKNTFRSIYGSIMAQGGIQFISTGVTIAVLWTGSV
                     LVIDQELTPGALMLFYSLVGYVLSPISSLITSNQTIQDALIAADRLFQIMDLERESDNS
                     QKIKLTPEMIGNISFENVAFRYGSRKKVFESLNLKIEKGKTTAVIGESGSGKTTLISLM
                     QHIYPIQDGQIRIGEFDIAQITNESLRRIVGTVPQQIELFAGSIAENIALGDLYPDMER
                     IIDLAEQLGLKEFIEKLPQNYMTYIGEHGASLSGGERQRLAIARALYKEPEILIFDEAT
                     SSLDSVSEKFVKQTLKSLATRGKTIIVIAHRLSTVRDADAIVVLDDGKVVQHGVHEQLI
                     HEDGIYRKLWN"
     PFAM_domain     5496..6296
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1140_0111"
                     /evalue="5.00E-46"
                     /label="ctg1_1140"
                     /locus_tag="ctg1_1140"
                     /protein_end="432"
                     /protein_start="165"
                     /score="157.7"
                     /tool="antismash"
                     /translation="ALFGALVYSILGLSTAIYVGKITDYVLVDKNLNLLHLMGIIMIAV
                     LLLRTFIGAMKSILALKTGQRIDAALILGYYKHLLTLPQQFFDTMRVGEIISRVNDAVK
                     IRSFINNVSLDLAVNVMILFFTSCLMFVYSWKLAVVTLLSAPLFLLVFWGFNRLNRKYQ
                     RRIMESAADLESQLVESINSISTIKRFGIEEYANLKTETRFVHLLKNTFRSIYGSIMAQ
                     GGIQFISTGVTIAVLWTGSVLVIDQELTPGALMLFYSLVGYVLSP"
     PFAM_domain     6486..6932
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1140_0112"
                     /evalue="9.10E-31"
                     /label="ctg1_1140"
                     /locus_tag="ctg1_1140"
                     /protein_end="644"
                     /protein_start="495"
                     /score="107.3"
                     /tool="antismash"
                     /translation="ESLNLKIEKGKTTAVIGESGSGKTTLISLMQHIYPIQDGQIRIGE
                     FDIAQITNESLRRIVGTVPQQIELFAGSIAENIALGDLYPDMERIIDLAEQLGLKEFIE
                     KLPQNYMTYIGEHGASLSGGERQRLAIARALYKEPEILIFDEATS"
     CDS             7157..8464
                     /gene_functions="transport (smcogs) SMCOG1076:RND efflux
                     system, outer membrane lipoprotein, (Score: 146; E-value:
                     2.3e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1141"
                     /transl_table=11
                     /translation="MKSMVFLVLCLLSGNLLYGQAPYTLGECIQQALHANVDIKRQQVK
                     LDKQAIRVETEKYSRLPDLNLNGTQQFDFGRSLNRDNTYTDVNSQTSSFSLTTEVGLFS
                     GFKTMHSIARQKLELKINRELLEKVRNDISLQVTICYYQILLDKEIAAIADEQIILTRE
                     QEEMTRVLATHGKVAESQVLTVKAQLANDELASVKAANTLRLSMINLLQLLELRDTAGF
                     DIVPVALDTLMPLAVSPDEIFAVSEQIMPEIKSARTAVESSQSAIRIAKAGYYPSLALA
                     AKISSGYYHNNDNNPPLDIQFKNNMQQTVYLTLRIPLFNRMTTRNAVRTAQKEREDSRL
                     AADNALKTLYKEIQKTWYDALSAHERYESTRHSVAANSEALRYAKEKYQAGKSTVYEYN
                     EAKMKLANSRSEQAQARYEFALRKKILDFYADQSIR"
     PFAM_domain     7235..7798
                     /aSDomain="OEP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02321.20"
                     /description="Outer membrane efflux protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1141_0113"
                     /evalue="9.60E-27"
                     /label="ctg1_1141"
                     /locus_tag="ctg1_1141"
                     /protein_end="214"
                     /protein_start="26"
                     /score="94.1"
                     /tool="antismash"
                     /translation="ECIQQALHANVDIKRQQVKLDKQAIRVETEKYSRLPDLNLNGTQQ
                     FDFGRSLNRDNTYTDVNSQTSSFSLTTEVGLFSGFKTMHSIARQKLELKINRELLEKVR
                     NDISLQVTICYYQILLDKEIAAIADEQIILTREQEEMTRVLATHGKVAESQVLTVKAQL
                     ANDELASVKAANTLRLSMINLLQLL"
     PFAM_domain     7907..8419
                     /aSDomain="OEP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02321.20"
                     /description="Outer membrane efflux protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1141_0114"
                     /evalue="2.10E-24"
                     /label="ctg1_1141"
                     /locus_tag="ctg1_1141"
                     /protein_end="421"
                     /protein_start="250"
                     /score="86.5"
                     /tool="antismash"
                     /translation="PEIKSARTAVESSQSAIRIAKAGYYPSLALAAKISSGYYHNNDNN
                     PPLDIQFKNNMQQTVYLTLRIPLFNRMTTRNAVRTAQKEREDSRLAADNALKTLYKEIQ
                     KTWYDALSAHERYESTRHSVAANSEALRYAKEKYQAGKSTVYEYNEAKMKLANSRSEQA
                     QARYEFAL"
     CDS             8487..8825
                     /locus_tag="ctg1_1142"
                     /transl_table=11
                     /translation="MQLFETIDRAKRMHGLIQHEATGDPQQFAERLHLCRRQFFNVLDE
                     LRDLGAEIRYDRVRCTYFYANDFDFQIVIKCCSLDEKEQRRISGGFFIKKIPSAILLHR
                     SDVLLCCD"
     CDS             8892..9065
                     /locus_tag="ctg1_1143"
                     /transl_table=11
                     /translation="MKNSELTTYGVAELNAQEMEEVNGGFWGALAAAVAAYLIISSIEY
                     PEDFVDGFLGNK"
     aSDomain        8925..9002
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1143_0023"
                     /evalue="5.30E-06"
                     /identifier="TIGR03949"
                     /label="ctg1_1143"
                     /locus_tag="ctg1_1143"
                     /protein_end="37"
                     /protein_start="11"
                     /score="24.1"
                     /tool="antismash"
                     /translation="AELNAQEMEEVNGGFWGALAAAVAAY"
     CDS             9077..9232
                     /locus_tag="ctg1_1144"
                     /transl_table=11
                     /translation="MKELSLEELVEINGGETGSRNGARIAGRLVGIALMGPLGGIYYCG
                     KDMGWW"
     CDS             9250..9699
                     /locus_tag="ctg1_1145"
                     /transl_table=11
                     /translation="MIFKYSSRKKQIGILSILFLMVVIYAIYRHYLRPYAIQYSDSRFL
                     KDLLYTFPNFWGSFMLYLMSKYFLNHTFWKSIWYVFALAVIYESLHIVNFGTSFDIYDI
                     LASVIALIFIVIYEKVIKPNVCRRKVLFSKQSCVNDNAGDDIWKE"
     CDS             10296..10655
                     /locus_tag="ctg1_1146"
                     /transl_table=11
                     /translation="MKKNYIIAGAIIGIIGILMAWIYRPYVEAHQIEDLYIGDTLECLF
                     FIPTGACLLYGISNKYSFGKVVLIIAFSTVLYNVIGGDFGFFVIRLVAILVSTVATYFI
                     QKCISRCAVPTKVNR"
     CDS             11053..11229
                     /locus_tag="ctg1_1147"
                     /transl_table=11
                     /translation="MKKVSVISNVLSIAAIIFLFILDYPFMSVGYIMKNVLILALILLS
                     ILIYVRKKQTENK"
ORIGIN
        1 ggatagccac gattacacct atcgccactc ggaacactcc gtttacaatc tctctaataa
       61 tgccccaaaa gatgccgaac atcccgaagg cggtgcgtac catcaagccg catatcgcaa
      121 gccctatgta ctgcgccatt tgtctgaaat ttgccgttgc cgtcatatct tcgctgtttt
      181 tgattttttt gttttttaat gcggattcaa gagctgaggg agttgagttt caaactatct
      241 tatctgcctc tcgtttatcc gacatttttt ttatgcgtct ttctgtcgca tcggtcgttt
      301 tcgtttcggg tgcttgaaaa ggtagggatt agggaatgca aggtttttcg ggaaaaatac
      361 tacccgcagg gctggagatt ttttccgaaa acaggaggct tgaccttgca ttcccgtcca
      421 atcccggaat tacctttgcg cccagaacgg aaatgactat ctgatgcggc tcactgaaag
      481 acgcgaaaat ggaggtaaac ggaagtggag gcagattgga caggaaaact tcaaaagaga
      541 aatccgtaaa aaagggaaaa cgccaaaagg aaaagggaca tagccggagg cgtgaaaccg
      601 ggcaaaccac cggcaaggaa gtatgatttt atatgtctgg ccgagcgtgt acggtcggac
      661 ggataaaatc attcttcccg gtttgcctgc cgtgtgtgac ggcttgttcc atttatggat
      721 cgggcggtca gacacggctt tccgcttacg gctcaaagga acagtggaaa aagaaaaatc
      781 gtcagaaacc cgtaaaagca cctctttggc ataagcacaa aagaaatggg ccttgcatca
      841 ttagtctaaa ctgttgttta ggcgtgaggc aaagcccttt tctccgctta tgcgtagtcg
      901 gcatacgttc gaccaaaatc cttttgggcg atggtgtgcc gacggacaaa accgctttta
      961 cggaaaaact tgtatgagaa gaaaaaatta gggagattca tttcaaaatc tcccgtttta
     1021 ttgttacttt tgcatacgaa gagttctttg aaggttacgc aacgcgcaga aggatgatgc
     1081 agtagataac taactaaatc gtaacctatt actatcatga gcaattaacc tacgctcagt
     1141 tccaataaat tacactcttt tcgtaacttc tttgcacaaa gatgtaaaat ttttttttat
     1201 cgcgcaaatt tttcaggcaa aaaaaattaa cctacacata accttagata acatagcctt
     1261 aacattgcat gaaattcgga ggctgtatct ttgccgtatc aaaaacaata aaaagtaaac
     1321 agacatgaaa gaaaatgtat ttaatgtatg cagaagaggc actgcaaaaa agaatgcgat
     1381 ggcgcaagta ccggatggat atctgaccgc tctgacaaac cgtgaactgg agatgattga
     1441 gggcggagac tgggagtaca ttgttgtaga tggagaaatt atcaggattt atatcccgaa
     1501 aaattaacgt aaagataacg tagcgttaac acaaggctcg aaaaagcggt tttacctttg
     1561 ctgtcggaat ataagaaaac aaaggatcat tagatgtgat aataatagtt agttatttat
     1621 taatgtaatt tttatgttca aatcccgcat gcgcatgcac cctctctgag aggacacgtg
     1681 tttttcggaa accggtataa agaaaaacgc gagtcctttt ggaagggctt ttaaaagaga
     1741 aagagcgcaa aacgggaacg gcaaaaggat gaaatgaaac agggaagaaa agaggcatta
     1801 agccttcata gattttatta atcaattaaa ttttaaagaa aatgaaagaa aaacggaatg
     1861 aatccactta cgcagtggaa gtgatgagtg agagtgaaat gacggaagtc aatggcggac
     1921 gttttgtgaa atggtggatg tatttaatat ctccgggagg tgcatttatt gcaggtagat
     1981 tcgaagatgg attgttgggt aagtaataaa gaaaagaata tggaaacaaa gaaagaaatt
     2041 atggcagaaa tgccattgtc ggaaatggaa aatgttgatg gtggtgttgt tatcacaact
     2101 cttgctgcag tctgtactgt agtgtggttt gcaggagaga tcgcctatca aatagggaaa
     2161 tcaatgcgat aaattttccg gtcatgaaga gtttagaagg aaacagacaa tcgaacgcta
     2221 agcaagcgtt aacaatcatg ttctaccttt caattgtaat ctacgtggca ggacaagttg
     2281 ctttccaaat cggagctgct atggctggag gctaaaaggg aaaaacaatg tttgaagaat
     2341 tgggggagtt ttccgtataa aaacttcccc caatttgctt ttttatatcg gttcttacga
     2401 gccttcacct tattaattaa aatgatataa gtaagcacaa aggttttgcg gtatggataa
     2461 aaaaatagag ccgattacgg aaataaaata aaacaagtat aattaaaaag aagagaaaag
     2521 agaaagatgt tatttatagc tagtgcctca tgcattcttg tattggctat acgatgcaag
     2581 aataagaaga taaaatatgc attgttggca tgttcgctgg tcttgttgat tttaagcatg
     2641 cttattacac tctgattttg tttcgtgaaa gtgcagcact tatccgatga tttcagggtt
     2701 tactcggcaa gacaggatgt gatgtttttg accggagagt gaccgattta cttctccggc
     2761 cacttgccgc cttttcggac aatcgaaacg cattacattg tgccaatacg gacgcgttat
     2821 gaaagggcat aactgaatac gttttgatga tctgtgcgaa ttattttttt cgaatcggaa
     2881 ttggataatt gaaatcttct ttttaatttc gcatcaatga atgtttaaca ataaaaaatg
     2941 aaacgtatga aacggtgtat ttttaacaaa gaatcgaatg cggataaggc attggtgatt
     3001 ttattctgcc tgtccattat catttatgtg gccggtgaaa tagcatacca attcggacaa
     3061 gctttggctg cggggtaagc gcattgaatg ctattcttaa gagtaattga attctttggc
     3121 ttcatgttct tcaaccgaat taattattaa aacagaacag taatggaaag acaattattt
     3181 aacctcattg tattgtcgtt aattattgca gccgactgtt tggcaattta tgacttgctg
     3241 cgttatgaaa aaaagcgtag tgtactgtat aaggtggtta tggtatgcct tattcttctt
     3301 ttaccattgt taggagtatc gatatattat gcaataaaga atcgtcactt aagacgaaga
     3361 tgctccgttt agtttcttac aagacattgt tttgaaaatt actcttttac aaaccaaaga
     3421 aataaaacac aaaatatcaa tccaggacat gaaaaaaaca atttggaaaa cagccttgat
     3481 cacccttggg gtatgggtgt tgtacgatat catccggaac ttacccgaga gtgtcgcagc
     3541 ttttaaagcc ggcatggatt tttgcatgaa tatgttataa tcggctggag aatgagggtg
     3601 gggcgcgatg cgttaatttg ttctttaacg tttacccttg ccccataatc ttatttattc
     3661 tcatagaact taagaggata tgccaaaatg taatgttttg acgcatcctc ttttggttgt
     3721 ccggtatcgg ttagccccct gctttgttaa cgtaaaaata acatgatgat aacatagctt
     3781 cagttgttcg ccatatactt ttgtcgtaag aatttaaaga cagaagctat gttgttaccg
     3841 aacgagttta ttgagaatag tattgagacg tatatctata aacatacaac aacgtctcaa
     3901 aaaatttact gggtcgtatt ggcggctgtg acagtggcat tagcttctct gccgtttatt
     3961 tatgtagata tatcggtaca ggggttggga atcatccggc ctgttgcgga aaaaacggag
     4021 atcaagtcgc ctgtaacaga actggtcgat tccgtctacg tccgtgaggg cgaacaagtg
     4081 aagaaaggcg atattttgtt gcgattccgt acaaacagtt cggattataa gatagcctat
     4141 caatcgaacc gcctgagcga ttacgccgaa caactaagcg atttgactta tttggcaaga
     4201 ggagcgtgtc ctccttcttt tcaatcgcct gtacgcaggc aggaatatca ttattatatc
     4261 aaacggaaga atgagttaga gacttcgttg gatcaggcgg aaaaagaata tctccgcaac
     4321 aaatccctgt ttgaaaagaa agtcattgcc gaagaagaat acgataagta tctctaccgc
     4381 tacaaaagtc agcagaacga gttggcctcg ctcatcgaaa atcagatgag tacatggcaa
     4441 gcaaatttga acgcactccg taactcacat agcgagatgc atacttccct aaagcaggaa
     4501 ataaaagata aggagatgta tttcgtcaag agcccggtca gcggaacgtt agatcagttc
     4561 tccgggatat atcgcggcag cagcatacgg gccggagaat ccctcgccgt gataagtccg
     4621 gactctacgc tgtatttcga ggtgtatgtg accccaagga atatcggtta tctgagtttg
     4681 ggcatgccgg tgattgtgca agtagaatcg ttcaattata acgaatgggg tacggtcggt
     4741 ggtacggtca aagatatatc gtcggatttt atgacggata aacaaggtca ttcttcttat
     4801 aaggtgaaat gtgggatgga cagagactac ctgcaactga agaacggacg aaccggtaag
     4861 ttaaagaaag gaatgaccgt cagtgctcat tttatgatta cccgtcgctc cctgttcgac
     4921 ctgctttacc agaagatgga tgattgggta aatcctgccc ggtataaaca agtatctaac
     4981 gattaaacat aaaaaaacaa atgaaaagag gaattaaagt taaacagcat gatataaccg
     5041 actgtggggc ggcttgtctg gcatccgttt gtgcttacca tggattacgt tttcccgttt
     5101 cacgtatccg gcagtatgct ttcacagaca aaaaaggaac gaatgtgctt gggcttactc
     5161 aagctgcgca taaactcggc ttatcggcca agggggtccg tgcgcttccg gaggctttgg
     5221 atatcgtacc caaaccggca attgcccatg ttattgtcaa agaacaatta caacattatg
     5281 tcgtagtcta taaagtaacg aagacacacg ttacctatat ggaccccgga gacgggcgca
     5341 tgcatcaaaa aacgcgtgag gagttcaata aagaatggac aaaggttatg gttattatgg
     5401 agcctgaaga gtctttccgg cgtggaaacg agaagaagag catcatctct caattcattg
     5461 ctttgcttgc gccacataaa agcgtcatgc ttcaagctct tttcggcgct cttgtatata
     5521 gtatattagg actttctaca gcgatctacg tcggtaagat tacagattat gtcttagtag
     5581 ataagaattt gaacctgttg catctgatgg gaataatcat gattgccgtc cttttattga
     5641 gaacgtttat cggtgcgatg aagagtattc tggccttaaa gaccggtcaa cgtatcgatg
     5701 ccgcattgat tctcggatat tataaacatc tgttgaccct ccctcagcaa tttttcgata
     5761 cgatgcgcgt aggcgaaatc atatcgcgag tgaatgatgc cgtaaagatt cgttctttta
     5821 tcaacaatgt ctcactcgat ctggctgtga acgtgatgat cctgttcttc acctcctgtc
     5881 tgatgtttgt gtattcatgg aagctcgccg tagttaccct cttgtcagcc cctctgttcc
     5941 tgcttgtgtt ctggggattc aaccgactga accgtaaata ccagcgccgc attatggaaa
     6001 gcgctgccga tcttgaatca cagttagtcg aatcgattaa ctccatttcg accatcaaac
     6061 ggttcgggat agaagagtat gccaatctga agaccgagac gcgctttgtc catctgttaa
     6121 agaacacgtt ccgcagtatc tatggctcta ttatggcaca gggtggcatt caatttattt
     6181 ctacgggagt gacgattgcc gtgttgtgga caggtagcgt actggtgatc gatcaggaac
     6241 tgacgccggg tgccctgatg ctgttctatt cattggtggg atatgtactg tctccgatct
     6301 cttcgctgat cacgtcgaac caaaccatac aggatgcgtt gattgcggca gatcgcttgt
     6361 ttcagattat ggatttggag agagaaagcg acaatagtca gaaaatcaag ctgacaccgg
     6421 agatgatcgg caatatttcg ttcgagaatg tagcctttcg ttacggttcc cgaaagaagg
     6481 tcttcgagtc gttaaattta aaaatagaaa aaggaaagac aacagccgtt atcggtgaaa
     6541 gcggctccgg taaaacaacg ctgatttcac tgatgcagca tatctatccg atacaagacg
     6601 gacagatacg catcggagag ttcgatattg cccaaattac gaacgagagt ttacgcagga
     6661 tcgttggtac tgttcctcag caaatcgaat tatttgccgg aagtattgcc gaaaatatcg
     6721 cgctcggaga tttgtatccg gatatggaac gaatcatcga cttggcggag caactaggtt
     6781 taaaggagtt tattgaaaaa ttaccgcaga attatatgac gtatatcggc gagcatgggg
     6841 catcgctttc cgggggagag cggcaacgtc tggccattgc acgtgcgtta tacaaagaac
     6901 cggaaatctt aatatttgat gaagcgactt cttcgctcga ttcggtttcg gagaaatttg
     6961 taaaacagac cttgaaaagt ctggcgacac gaggaaagac gattattgtg attgctcatc
     7021 gactgagcac cgtcagagat gccgatgcga tcgttgtgct ggatgatggg aaggtggttc
     7081 agcatggggt gcatgagcag ttgatacatg aggacggtat ttaccgaaag ttgtggaacg
     7141 agcaatacgg catggtatga aaagcatggt ttttcttgta ttgtgcctgt tgtcaggaaa
     7201 tttactgtat gggcaagctc cgtacacatt aggagaatgc atacaacaag ctctgcatgc
     7261 caatgtggat atcaaacgcc aacaggtaaa gttggacaag caggccattc gggtcgagac
     7321 ggaaaagtac agccggttgc cggacctgaa tttgaacgga acacagcaat ttgatttcgg
     7381 gcgttcgctg aaccgtgata atacgtatac ggatgtcaac tcacaaacaa gttcattttc
     7441 tttgaccaca gaagtggggc tgttctccgg atttaaaacg atgcattcga tcgcacggca
     7501 aaagttagaa ttaaaaataa atcgagaatt attagagaaa gtacggaatg atatttcgtt
     7561 gcaagttacc atctgctatt atcagattct gctcgataag gagattgcag cgatagccga
     7621 cgaacagatc atattgacgc gtgaacagga agaaatgaca cgggtgctgg ctacacatgg
     7681 caaagtagcg gaatcacaag tgttgactgt caaggcacag ttggcaaatg acgaattagc
     7741 atcggtcaaa gcagcgaata cacttcgcct ctccatgatc aatttgcttc agttacttga
     7801 gctacgcgat accgccggtt tcgacatcgt gcctgttgcg ctcgataccc tcatgccttt
     7861 ggccgtatct ccggatgaga tttttgccgt atcggaacag attatgcctg agatcaaaag
     7921 cgcccgtaca gctgttgaga gcagccaaag cgctattcgc atagccaaag ccggttatta
     7981 tccgtcctta gcattggccg caaaaataag tagcggatat tatcacaata atgacaataa
     8041 tccgccatta gacatacagt ttaaaaacaa tatgcagcaa acggtatacc tcacgctccg
     8101 tattccgcta tttaaccgga tgacgaccag gaatgccgta cgcacagcac aaaaagaacg
     8161 ggaggatagc cgtcttgccg cagacaatgc gttaaaaacg ttgtataagg aaatacaaaa
     8221 gacgtggtac gatgctctct ccgcacacga gcgctacgag tcgacccgcc actccgtcgc
     8281 ggccaacagt gaggcattac gctatgcaaa agaaaaatat caagcgggaa agagtaccgt
     8341 atacgaatat aacgaagcaa aaatgaaact ggcgaatagt cgctccgaac aggcacaggc
     8401 cagatatgaa tttgccttgc ggaaaaagat attggatttt tatgccgacc aatccatcag
     8461 gtagaaacga tcaaaaaagg atgattatgc aattatttga aaccattgac agagccaaac
     8521 gcatgcacgg tctgatacag cacgaggcaa cgggagaccc acagcaattt gccgagcgcc
     8581 tgcatctttg tcgccgacag tttttcaatg tgttggacga actgagggat ttaggtgcag
     8641 agatacgata tgacagagta cggtgtacgt atttttacgc caatgacttc gattttcaga
     8701 tcgtaatcaa atgctgctcc cttgacgaaa aagagcagag gcggatttcc ggaggatttt
     8761 ttatcaaaaa aataccgagt gcaattttat tgcaccgaag cgatgtactt ttgtgttgtg
     8821 attaaacgaa tggtgcacaa ttcgggagat tgcagaaaga ctttattttg taaatttaaa
     8881 attttaaaac aatgaaaaat tcagaattga ctacttatgg agtagcagag cttaatgctc
     8941 aagagatgga agaagtgaat gggggatttt ggggcgcttt agcggctgct gtcgcggctt
     9001 atttaatcat tagctcaata gagtatcctg aggatttcgt agatggtttt ttaggtaaca
     9061 aataaactga atgatcatga aagaactaag tttagaagaa ttggttgaga taaatggagg
     9121 tgaaacaggt tctcggaacg gtgctcgcat agcagggcga cttgttggga tagcattgat
     9181 gggacccttg ggcggaattt attattgcgg taaagatatg ggatggtggt aataaacaag
     9241 acttatcgta tgatttttaa atattcgtct cgaaagaagc agattggtat attgagtatt
     9301 ttgttcttga tggtggttat atatgccata tacaggcatt atctacgtcc ttatgcgatt
     9361 caatattcag acagtcgatt cttgaaagat ttgctttata catttcctaa tttctggggc
     9421 tcattcatgc tttatctgat gtctaaatac tttctgaacc atactttttg gaaatcgata
     9481 tggtatgtgt ttgcattggc cgttatatat gaatcgctcc atattgtgaa ttttgggaca
     9541 agtttcgata tttatgacat cttggcttcg gtgattgctc ttatattcat tgtgatatat
     9601 gaaaaagtca tcaaaccaaa tgtttgtaga agaaaggtac ttttctctaa gcaatcttgt
     9661 gtaaatgata atgcaggaga cgacatatgg aaagagtaag atagccttat accatacaaa
     9721 ccaaatcgag taggaggaaa acgtcttcct actcgattta ctataaaaca tatcaaacca
     9781 aattgtttgc tgttttggaa tgaagagact ttctctatat taacaaatcc agtaatgaaa
     9841 caacgcattg atttaagatg atctttctca gcggtattcc attatgaatc gcgttttatt
     9901 ctaccatcct ttccaaacga ttacgggctg ttctttgggc gctttttctc gtgccgacgc
     9961 tgctgtgcgg tcaacctcgt tcggtcatta cggggagcgt cgcagatgag cataaccggc
    10021 cgcttccgaa cgtgagcctt ttcttcaaac aggcgaaaag aggaaccgtt acgaattccg
    10081 acgggcaatt ccggctccgg ctgccagaaa caggcgatac gctgacatat cgtgtacgaa
    10141 acacaggccg ccatacccat agcgcaagac aggcttactt tgttcattcg attagttctc
    10201 gccgatgtac cactgaacga agtcatcgtt acgaatcttt cggctcgcga gctgttacaa
    10261 atttatagct gtaattttta gacataaaca acatgatgaa aaagaattat attattgcag
    10321 gagccattat tggcattatc gggatactga tggcatggat atacagaccg tacgtcgaag
    10381 cacatcaaat tgaggattta tacataggag atacgcttga atgccttttc tttatcccta
    10441 cgggagcgtg tcttctttat ggtatcagta acaaatactc ttttggaaag gtcgtattaa
    10501 ttattgcttt ctcaacggta ctctataatg tgataggggg agatttcgga ttttttgtaa
    10561 tccgtcttgt tgccatactg gttagcacag ttgccactta tttcatccaa aaatgtatca
    10621 gccgatgtgc cgtcccaacg aaagtcaata gatagatcgt tctatcgtat gatttttaaa
    10681 tagttgtctc gaaagaaaca gattgcgata gtccatgttc tgttcttgat tgaacgaaca
    10741 tgaaaaattt tgattgggct acctacggag tagcagagct taatgctcaa gagatggaag
    10801 aagtgaatgg gggagatgga aaatttcatt attgggagtt tggcttggca tgtgttttgc
    10861 ttggtcctat aggtggggca ttttatctat taggtgttgc acaaaattga actaaaataa
    10921 tttgatattt tgtaattatg tttgaagaat taactattac agagcaggag aatatctctg
    10981 gaggagagct tgttatcgct ataattgctt ttttctgcta ccaattaagt aaagattaac
    11041 tttggaagaa taatgaaaaa agttagtgtg atttctaatg tgttaagcat tgctgctatt
    11101 atattcctct tcattttaga ctatccgttt atgagtgtcg gatatattat gaagaatgta
    11161 ttaattttag cgcttatctt gctatcgata ttgatttatg tacgaaaaaa acagacggaa
    11221 aataaatagc ttttcaagtg tttgtttttt ttagttattg ttgctttgca aatgtgatgt
    11281 tttgattgtc aatcagaggt tgacacaaga tgtttaattg aatatcggga atctttatct
    11341 tgtacagagc ataggattcc cgattttgtc attcatattg cttctgtttt gcagatcgat
    11401 cattttaaga cagagaacta tacggatttt atgcgtttgc atactgtgcg tggtgaacac
    11461 cggtatgtta agcgcgatag atggaatttt ttttgcatct gatcgaaaac gcttctatct
    11521 ttgtgcgttt attttttata ttttttataa tcgtgttgat tgcggctctt gtgcgtcagg
    11581 cagtagagat gttgtccacc acaatataag catattgcct gcatttcgat tgtcaaccga
    11641 taaataaatg atcaaaacat agaaaaggac gatggtcaga tgaaaagaat tatatgtatt
    11701 atgcttgtta ttatgacagg tatgtattta ggtgcagggc cgtcgaggat gtcggctgcc
    11761 acagctgctc ctcgtgcagg tttatttgat ttcttcagaa aaaagaagaa gaaaacggct
    11821 gcaacggaga cgaaaagtga ctatgagaaa ctggtggcag acgcttgtcg gagcgagggt
    11881 atgtttatcg tttatcagaa gaagaacgat tattactttg agatacccgt taggctgctc
    11941 ggccgtgata tgcttgttgt gaacaagctg cagcgcgtcc cctcagagtt gaacgatgcc
    12001 ggcgtaaacc gcggcgtgaa ctatgagaat cagatggtgc gcatggagtg ggacaagcgt
    12061 gcgggcaagt tactctttcg gcagcaacgc ccactacccg attcaccgca ggaagatgcg
    12121 atacaccgtt cggtagcgga caatttcatc tcgccgctta
//
