GCF_900103815.1_IMG-taxon_2657245269_annotated_assembly_genomic - 4 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_FNHZ01000001 (original name was: NZ_FNHZ01000001.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	NRPS	305,901	349,173

NZ_FNHZ01000003 (original name was: NZ_FNHZ01000003.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	lassopeptide,RRE-containing	37,246	62,866
Region 6.2	RiPP-like	265,821	278,061

NZ_FNHZ01000005 (original name was: NZ_FNHZ01000005.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 9.1	ranthipeptide	58,093	79,738

Region	Type	From	To	Similarity
Region 2.1	NRPS	305,901	349,173
Region 6.1	lassopeptide,RRE-containing	37,246	62,866
Region 6.2	RiPP-like	265,821	278,061
Region 9.1	ranthipeptide	58,093	79,738

No secondary metabolite regions were found in these records:: NZ_FNHZ01000012 (original name was: NZ_FNHZ01000012.1); NZ_FNHZ01000006 (original name was: NZ_FNHZ01000006.1); NZ_FNHZ01000011 (original name was: NZ_FNHZ01000011.1); NZ_FNHZ01000002 (original name was: NZ_FNHZ01000002.1); NZ_FNHZ01000008 (original name was: NZ_FNHZ01000008.1); NZ_FNHZ01000004 (original name was: NZ_FNHZ01000004.1); NZ_FNHZ01000010 (original name was: NZ_FNHZ01000010.1); NZ_FNHZ01000007 (original name was: NZ_FNHZ01000007.1); NZ_FNHZ01000009 (original name was: NZ_FNHZ01000009.1)

Compact view

c00002_NZ_FNHZ.. - Region 1 - NRPS

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Location: 305,901 - 349,173 nt. (total: 43,273 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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Gene details

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NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Pfam domains

TIGRFAM domains

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000460.1	0.29	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0000343.1	0.24	NRP	enterobactin	Pseudomonas sp. J465
BGC0001444.1	0.23	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.23	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000410.1	0.22	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001890.1	0.22	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0000225.1	0.22	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0000412.1	0.22	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000423.1	0.21	NRP	scabichelin	Streptomyces scabiei 87.22
BGC0001721.1	0.21	NRP	ornibactin	Burkholderia cepacia

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000460.1	0.62	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0000343.1	0.57	NRP	enterobactin	Pseudomonas sp. J465
BGC0001444.1	0.56	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0001538.1	0.56	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0000410.1	0.55	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001890.1	0.54	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116
BGC0000225.1	0.54	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0000412.1	0.54	NRP	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000423.1	0.54	NRP	scabichelin	Streptomyces scabiei 87.22
BGC0001721.1	0.54	NRP	ornibactin	Burkholderia cepacia

Similar known gene clusters

No matches found.

Module view

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Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 305900 - 349173:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg2_275

Search NORINE for peptide: strict or relaxed

AMP-binding (17..413): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: gfpyLgTgAK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 40% (weak)

ctg2_277

Search NORINE for peptide: strict or relaxed

AMP-binding (14..427): X

NRPSPredictor2: dhb, sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: dhb, sal
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: aFPSlGVtfK
Nearest Stachelhaus code:: pip
Stachelhaus code match:: 60% (weak)

ctg2_280

Search NORINE for peptide: strict or relaxed

AMP-binding (446..852): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMFniGvlWK
Nearest Stachelhaus code:: thr
Stachelhaus code match:: 60% (weak)

c00006_NZ_FNHZ.. - Region 1 - RRE-containing,lassopeptide

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Location: 37,246 - 62,866 nt. (total: 25,621 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Lasso peptides

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.1	0.61	RiPP	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.1	0.54	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0001356.1	0.36	RiPP	paeninodin	Paenibacillus dendritiformis C454
BGC0000550.1	0.31	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000624.1	0.31	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001407.1	0.31	RiPP	bicereucin	Bacillus cereus SJ1
BGC0001388.1	0.31	RiPP	gassericin E	Lactobacillus gasseri
BGC0000619.1	0.31	RiPP	gassericin T	Lactobacillus gasseri
BGC0001602.1	0.31	RiPP	gassericin-T	Lactobacillus gasseri
BGC0000516.1	0.31	RiPP	geobacillin II	Geobacillus thermodenitrificans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.1	0.64	RiPP	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001645.1	0.61	RiPP	lagmysin	Streptomyces sp. NRRL S-118
BGC0000796.1	0.53	Saccharide	S-layer glycan	Paenibacillus alvei
BGC0001356.1	0.50	RiPP	paeninodin	Paenibacillus dendritiformis C454
BGC0001395.1	0.48	Other	teichomycin	Actinoplanes teichomyceticus
BGC0000845.1	0.47	Other (Non-NRP beta-lactam)	clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000789.1	0.46	Saccharide	O-antigen	Escherichia coli
BGC0000550.1	0.46	RiPP	salivaricin G32	Streptococcus salivarius
BGC0000624.1	0.46	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001407.1	0.46	RiPP	bicereucin	Bacillus cereus SJ1

Similar known gene clusters

No matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

Lasso peptides

Core peptide predictions

No core peptides found.

c00006_NZ_FNHZ.. - Region 2 - RiPP-like

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Location: 265,821 - 278,061 nt. (total: 12,241 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

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Gene details

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MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.1	0.26	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000558.1	0.24	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000504.1	0.23	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001862.1	0.21	RiPP	geocillicin	Aeribacillus pallidus
BGC0001930.1	0.21	RiPP	pallidocin	Aeribacillus pallidus
BGC0001861.1	0.21	RiPP	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.1	0.21	RiPP, Terpene	bacillicn CER074	Bacillus mycoides
BGC0000525.1	0.20	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000484.1	0.20	RiPP	glycocin F	Lactobacillus plantarum
BGC0000516.1	0.20	RiPP	geobacillin II	Geobacillus thermodenitrificans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.1	0.60	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000558.1	0.57	RiPP	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000504.1	0.56	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001862.1	0.54	RiPP	geocillicin	Aeribacillus pallidus
BGC0001930.1	0.54	RiPP	pallidocin	Aeribacillus pallidus
BGC0001861.1	0.54	RiPP	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.1	0.53	RiPP, Terpene	bacillicn CER074	Bacillus mycoides
BGC0000525.1	0.52	RiPP	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000484.1	0.52	RiPP	glycocin F	Lactobacillus plantarum
BGC0000516.1	0.52	RiPP	geobacillin II	Geobacillus thermodenitrificans

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

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Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names

c00009_NZ_FNHZ.. - Region 1 - ranthipeptide

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Location: 58,093 - 79,738 nt. (total: 21,646 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

MIBiG comparison

KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.17	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000601.1	0.17	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0000626.1	0.16	RiPP	thuricin	Bacillus thuringiensis
BGC0001391.1	0.16	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0000519.1	0.15	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000500.1	0.15	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000554.1	0.15	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.1	0.15	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.1	0.15	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000552.1	0.15	RiPP	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000599.1	0.48	RiPP	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000601.1	0.48	RiPP	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0000626.1	0.47	RiPP	thuricin	Bacillus thuringiensis
BGC0001391.1	0.46	RiPP	thusin	Bacillus thuringiensis serovar rongseni
BGC0000519.1	0.46	RiPP	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000500.1	0.46	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000554.1	0.46	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.1	0.46	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.1	0.45	RiPP	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000552.1	0.45	RiPP	SmbA, SmbB	Streptococcus mutans

Similar known gene clusters

No matches found.

Detailed Pfam domain annotation

Selected features only

Expand to show all names

Detailed TIGRFAM domain annotation

Selected features only

Expand to show all names