LOCUS       c00002_NZ_JYGP..       10303 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JYGP01000002.1 Streptococcus mitis strain OT25 TZ90_contig000002,
            whole genome shotgun sequence.
ACCESSION   NZ_JYGP01000002
VERSION     NZ_JYGP01000002
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:52:31
            Original ID  :: NZ_JYGP01000002.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 510878
            Orig. end    :: 521181
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10303
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[515878:516181](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5303)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10303
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10303
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(537..1178)
                     /locus_tag="ctg2_511"
                     /transl_table=11
                     /translation="MLNKVKTKALISVGAVAATSFILMMGYTAGQHSTAKQSRKEIELA
                     AAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELTSQN
                     DAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTNQTETRT
                     VKLSYSKLPGKLLVNQVQVWKSGLDDLDKVTPKTLEESSSVPSLPNTTTK"
     CDS             1353..1721
                     /locus_tag="ctg2_512"
                     /transl_table=11
                     /translation="MIKQITAHVNKSIQSILGQKVEFVKQDEQAFTRKRRLSLETMIRT
                     ILGMGGKSLSKELLDAKLTVSNSAFIQRRYQIKPEAFYALFKKFTAPIPFNTDFPIFAA
                     DGSDICIPRNPMDTETSV"
     CDS             complement(2256..2888)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 175.8; E-value:
                     1.9e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_513"
                     /transl_table=11
                     /translation="MIELKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMN
                     MIGKLESYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQK
                     LSRSEQRLRQKQALEQVGLAYLNLDKRIFELSGGESQRVALAKVILKNPPLILADEPTA
                     SIDPATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVITMDRLK"
     aSDomain        complement(2271..2879)
                     /aSDomain="TIGR03608"
                     /aSTool="tigrfam"
                     /description="L_ocin_972_ABC: putative bacteriocin export
                     ABC transporter, lactococcin 972 group"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_513_0001"
                     /evalue="1.50E-79"
                     /identifier="TIGR03608"
                     /label="ctg2_513"
                     /locus_tag="ctg2_513"
                     /protein_end="206"
                     /protein_start="3"
                     /score="264.2"
                     /tool="antismash"
                     /translation="LKQVSKSFGERELFSNLSMTFEAGKVYALIGSSGSGKTTLMNMIG
                     KLESYDGTIFYRGKDLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQKLSR
                     SEQRLRQKQALEQVGLAYLNLDKRIFELSGGESQRVALAKVILKNPPLILADEPTASID
                     PATSQLIMEILLSLRDDNRLIIIATHNPAIWEMADEVITM"
     PFAM_domain     complement(2400..2837)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_513_0001"
                     /evalue="3.50E-31"
                     /label="ctg2_513"
                     /locus_tag="ctg2_513"
                     /protein_end="163"
                     /protein_start="17"
                     /score="108.6"
                     /tool="antismash"
                     /translation="SNLSMTFEAGKVYALIGSSGSGKTTLMNMIGKLESYDGTIFYRGK
                     DLANYKSSDFFRHELGYLFQNFGLIENQSIEENLKLGLIGQKLSRSEQRLRQKQALEQV
                     GLAYLNLDKRIFELSGGESQRVALAKVILKNPPLILADEPTA"
     CDS             complement(2890..4905)
                     /locus_tag="ctg2_514"
                     /transl_table=11
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSHYYPNVVVRDSSPET
                     TFQHVATRLEKLAEETDSFIAIQHQDLNSEGTPVFSYTTFGNGKLPDGLQEKNLEDAQS
                     SSVETNYFVFDGNLDIHLLREELSQLGLTNMHLIIPSKLSTLMAIFSNGFQLIGLLIFI
                     LTFGALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLAILMQK
                     ILSLPTQSLMTIGEGLLSYNLILLSVSLFFAQLFAVGIKKIHLMQIIKGQVPVRGIISL
                     ILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSFSREGTSPGFDEQ
                     AQRKLRTWYQLMDLAVSEKKAFLSRHQLIDRSLQNGMASSKNLTTSTEWHDYSPNGNVL
                     IVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRVSS
                     RDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSIFFWVDAV
                     QNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIAT
                     SILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLMVEI
                     VVAFIVSLLFTGLSLLQLHVQMQKENKMSMLVLKGG"
     PFAM_domain     complement(2896..3195)
                     /aSDomain="DUF1430"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07242.13"
                     /description="Protein of unknown function (DUF1430)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_514_0002"
                     /evalue="5.40E-25"
                     /label="ctg2_514"
                     /locus_tag="ctg2_514"
                     /protein_end="670"
                     /protein_start="570"
                     /score="87.7"
                     /tool="antismash"
                     /translation="VLGIATSILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLF
                     AQLGVFLLGFVASVFLMVEIVVAFIVSLLFTGLSLLQLHVQMQKENKMSMLVLKG"
     aSDomain        complement(2896..4905)
                     /aSDomain="TIGR01654"
                     /aSTool="tigrfam"
                     /description="bact_immun_7tm: bacteriocin-associated
                     integral membrane protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg2_514_0002"
                     /evalue="2.40E-69"
                     /identifier="TIGR01654"
                     /label="ctg2_514"
                     /locus_tag="ctg2_514"
                     /protein_end="670"
                     /protein_start="0"
                     /score="232.5"
                     /tool="antismash"
                     /translation="MKKLFILISNLLASLFFVWVFTIWTDTYVSHYYPNVVVRDSSPET
                     TFQHVATRLEKLAEETDSFIAIQHQDLNSEGTPVFSYTTFGNGKLPDGLQEKNLEDAQS
                     SSVETNYFVFDGNLDIHLLREELSQLGLTNMHLIIPSKLSTLMAIFSNGFQLIGLLIFI
                     LTFGALTLISQISQLRSSGIRLISGEKRWSIFLRPVGEDLKGIAVGFSLAGVLAILMQK
                     ILSLPTQSLMTIGEGLLSYNLILLSVSLFFAQLFAVGIKKIHLMQIIKGQVPVRGIISL
                     ILIGQLLAIIIVTLGIGSSLKYSQAWQQHRIGQEAWSQERQLITLSFSREGTSPGFDEQ
                     AQRKLRTWYQLMDLAVSEKKAFLSRHQLIDRSLQNGMASSKNLTTSTEWHDYSPNGNVL
                     IVTPQYLERQNIPVDTTIEQKMNHLDVGEFVLLLPEHLRSEEEHYKSVFEDDLTSRVSS
                     RDERQQMTATVGYLESGQDRFVYNTTPISYQQFLKDPIIIVITPQSTGPQSIFFWVDAV
                     QNYVLFNQLSDAQELIQRQGIENWVSEMQTGYHNYITLLDNIQRERWVMLAGAVLGIAT
                     SILLFNTMNRLYFEEFRRAIFIKRIAGLRFLEIHRTYLFAQLGVFLLGFVASVFLMVEI
                     VVAFIVSLLFTGLSLLQLHVQMQKENKMSMLVLKG"
     CDS             complement(5001..5303)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_515"
                     /sec_met_domain="Lactococcin_972 (E-value: 9.2e-08,
                     bitscore: 29.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKFRKVVASSLAVLACSLALPVLAVSLHGGEWTYGGYHDPNNWG
                     AFSNYYHGSEDHWAYVGSNGRDNQKTAYAGAHSAAYAFVNTNFGEQVTFDAGLQE"
     PFAM_domain     complement(5052..5216)
                     /aSDomain="Lactococcin_972"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09683.12"
                     /description="Bacteriocin (Lactococcin_972)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_515_0003"
                     /evalue="2.70E-08"
                     /label="ctg2_515"
                     /locus_tag="ctg2_515"
                     /protein_end="84"
                     /protein_start="29"
                     /score="34.3"
                     /tool="antismash"
                     /translation="GGEWTYGGYHDPNNWGAFSNYYHGSEDHWAYVGSNGRDNQKTAYA
                     GAHSAAYAFV"
     CDS             5975..6424
                     /locus_tag="ctg2_516"
                     /transl_table=11
                     /translation="MTTLAEKFRLKRKELRLSQQTLAEGICEQEYEVNYFHLMELYQTK
                     NFEHQEFLFGYIRVRYNYAHYLVSKEKYNEAIQEALETIELCKQRQTSYQLAPLLILVG
                     NAGAKFLDKEQVKNYYIEARELCKIYNNPLMLMKIENYLKELDIV"
     CDS             complement(6563..6859)
                     /locus_tag="ctg2_517"
                     /transl_table=11
                     /translation="MNDLLLIPVIFLAVGGILILLWRLFLIASGLFLIGFVSFLIFVEV
                     YGIYLFFTEPSLYFDDIRQHGLTSFTAVYLFINLMWVLGFSWRFINSMNKEKM"
     CDS             complement(6873..7157)
                     /locus_tag="ctg2_518"
                     /transl_table=11
                     /translation="MMEDTYYQLEEALIQGFQTPEEYQAYKELKEHYEEVTGDYSFSKR
                     ELTSQLEIALQNHRGVDFEEHEKEEYLDLVQKLEEFDSSLATHYRQLID"
     CDS             complement(7232..8203)
                     /locus_tag="ctg2_519"
                     /transl_table=11
                     /translation="MVRRWVLSLQRNGRIIRQGNENKEVDIYHYITKGSFDNYLWATQE
                     NKLRYIKQIMTSKEPIRAAEDIDEQTMTASDFKALATGNPYLKYKMEIENDLTLLENQR
                     RAFQRSKDHYRHTISYCEENMPILEKRLSKYEGDIQQSEISKDQAFSMTVGKQAFDQRS
                     EAGESLHRLIRHNQADSKEFRTLASYRGFDIKMLSLPINQPLPETFSVKIVGENQYSVS
                     LDLYSPLGTIQRLQHTIDHIKEDQVKTQNLLDELKDKWTTAKVEIENNFPKEEDYQTKK
                     AEYDVLAPLIETETDLDIIDQALRQFHEKGKEKEEQLSFELD"
     CDS             complement(8284..10095)
                     /locus_tag="ctg2_520"
                     /transl_table=11
                     /translation="MRNPQNVLNNLTKHSKDKNYQFERLYRLLYNKEMYLVAYQTIYAN
                     PGHLTPGVDELTIDGMSIARIDQLIDSLKDESYQPHPSRRTYIPKKNGKLRPLGIPSFD
                     DKLLQQVIKMILEAIYEGQFEPSSHGFRPNKSCHTALTQIQKTYTGTKWFIEGDIKSFF
                     DNINHDVMIHILRERITDERFLRLIRKFLNAGYVEDWKFYKTYSGTPQGGIISPILANI
                     YLDKFDKYMTDYVKNFCQGKYRKRTPEYRQNEIELGKARRALEYVSTENQRQEVIQRIR
                     QLEKERVLIPHSDPMDSSFKRLTYTRYADDFICGVIGSKEDALRIKADIKDYLEAVLKL
                     ELSVEKTLITNARDKAKFLGYHLYIRQSNLAKRDSAGRLVRNYTGRLVLEVSIETIRDR
                     LLSYGAMKMTYHRGYEVWKPTARYFMKDCDDLEILERYNAEIRGFYNYYCIANNSSILH
                     RFKYIMEYSMYKTYATKYRTTKSHIIRKYKKDGQFRVQYIGRKGDTMTRYFYNGGFKRQ
                     KKSFLDNDNLPNTAKYFSRTNLIDRLKASRCEYCQATDSSLEIHHVRKLKDLKGKTFWE
                     RLMISRQRKTIALCKDCHKKLHHGKLD"
     PFAM_domain     complement(8467..8943)
                     /aSDomain="Intron_maturas2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01348.23"
                     /description="Type II intron maturase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_520_0005"
                     /evalue="3.60E-14"
                     /label="ctg2_520"
                     /locus_tag="ctg2_520"
                     /protein_end="543"
                     /protein_start="384"
                     /score="53.0"
                     /tool="antismash"
                     /translation="GRLVLEVSIETIRDRLLSYGAMKMTYHRGYEVWKPTARYFMKDCD
                     DLEILERYNAEIRGFYNYYCIANNSSILHRFKYIMEYSMYKTYATKYRTTKSHIIRKYK
                     KDGQFRVQYIGRKGDTMTRYFYNGGFKRQKKSFLDNDNLPNTAKYFSRTNLIDRL"
     PFAM_domain     complement(9397..9834)
                     /aSDomain="RVT_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00078.29"
                     /description="Reverse transcriptase (RNA-dependent DNA
                     polymerase)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg2_520_0004"
                     /evalue="9.50E-34"
                     /label="ctg2_520"
                     /locus_tag="ctg2_520"
                     /protein_end="233"
                     /protein_start="87"
                     /score="116.9"
                     /tool="antismash"
                     /translation="IPKKNGKLRPLGIPSFDDKLLQQVIKMILEAIYEGQFEPSSHGFR
                     PNKSCHTALTQIQKTYTGTKWFIEGDIKSFFDNINHDVMIHILRERITDERFLRLIRKF
                     LNAGYVEDWKFYKTYSGTPQGGIISPILANIYLDKFDKYMTD"
ORIGIN
        1 cttgggatag aatgattctt ataaatccct tgtaggcttg ctgcctgcaa cttatgacga
       61 tgatcaaagc ttttaaacac aataacaggt tcaactgttt catttgtctt ccagctggtt
      121 tgtgctatca aaccttgttg tatcatcttt tgtacgattt cttctgaaat tcctctacat
      181 tctgttaaat aatatctggc cagactacag ttagaatctt ctattctctt taaaggataa
      241 taaaatggtc tctctctttt ttcttgaaca gcttcttttt gaaaaggttc ttcagaaaga
      301 aaggctagag cttctttaaa ggaaattccc ttaacaagtc gaacaaaatc aatgacatca
      361 ccttgaatat ctcttgaaaa ccatttaaaa gtattggtag ttgaaaaaat ccgaaatgaa
      421 tcgtgttcag gatgttcata gacactgctc gaaacttgtt taaaggagat acctaaacga
      481 ttggctacat caagaattga aatttgctta cattcttcta tttccatgca atatcatcat
      541 tttgtcgtag tatttggcag tgatggaaca gatgatgatt cttctaaagt tttaggagtt
      601 accttatcta aatcatctaa cccagatttc caaacctgta cttgattgac caataactta
      661 ccaggtagtt tcgaataaga caacttaacc gttctggttt ctgtctgatt ggtctttgat
      721 tggttggcat tctttaaatc agatacatag gttacattat aagagaccat ggcaatggct
      781 tgattcgtag tctgattgac aaagatatca gctttttcaa aatgataatc caaaatatag
      841 tccttataca cttggttcat ggcatcgttt tgacttgtca attcttgaga ataagccgat
      901 tcagtcatat aaggttgaat gcgtgtatta ttttctccga gcttttcttt cgtatagtac
      961 tgtgttaaaa attcttttac agtatccgat gacaaaatgc tggctttatc ttctgcttgt
     1021 ttgtcctcta caagtttagc tgcagccaat tcgatttctt tgcgactttg tttagcagta
     1081 gaatgttgcc cagcagtata tcccatcatg agaataaagc tagttgcggc tactgctcca
     1141 acactaatta aggctttagt tttgacttta tttaacatct tagaccttct ttctataaaa
     1201 actaggtcaa gaataccaga tatgacttgg agcttttatc acaagaaaaa gtctctgaag
     1261 agtccaatat aattaagtta agaaattcaa atacgattct gtatttgggt ttctttttta
     1321 tgtgataaac tagagttacg gaggtatttg ccatgataaa acaaataaca gcccacgtga
     1381 ataagagtat tcagagtatc cttggtcaaa aagttgagtt tgtcaaacaa gatgaacagg
     1441 cctttactcg taaaagaagg ttatcactag aaaccatgat tcgtaccatt ctgggaatgg
     1501 gagggaaatc actgtcaaaa gaattactag atgccaaact gacagtttca aattcagcct
     1561 ttattcaaag acgctatcaa ataaaacctg aggctttcta tgccctattt aaaaaattta
     1621 cagcacctat tccattcaac actgatttcc caatattcgc tgcagatggg agtgatatct
     1681 gtattcctcg aaatcccatg gatacagaaa cctctgtcta aacccaaacg gatgttaaat
     1741 cctataatct catacaaata aatgccctat ccgacttgac gagtggagtg tatagagatg
     1801 tttctattca agacaaacat actcaacatg agcgcttagc tctgattcag atgatggagg
     1861 cttctccatt tcgagaaagc tcttgttatc atggtgagtt aatcgctcca atgacttacg
     1921 aagaaacgat gagcagcgac ttttttgaag cttggtttca gaagtttctc ttaccaacat
     1981 taaatgtacc atcagttatt attatggata atgcaagatt ccatagaatg gggaagctag
     2041 aacttttgtg taaagagttt gggcataaac ttttacctct tcctccctac tcacctgagt
     2101 acaatcctat tgagaaaaca tgggctcata tcaaaaagca cctcaaaaag gtattaccaa
     2161 attgcaatac cttttacgag gctcttttgt cctgttcttg tttcaatcaa ctataatatt
     2221 tcagtaactc atcgtgcaat taaaaacaag gatttttatt tcagacgatc catcgtgatc
     2281 acttcatcag ccatctccca aattgccgga ttatgtgttg cgataatgat tagcctatta
     2341 tcatctcgaa gagatagcaa aatctccata atcaactgag aggttgctgg gtctattgaa
     2401 gctgttggct catctgccag aataaggggt ggattcttta agataacttt tgccaaggca
     2461 acccgttgcg attctccgcc cgataactca aagatgcgct tatctaggtt aagataagcc
     2521 aggccgacct gttctaaagc ctgcttctgc ctcaaccgct gttccgaccg actcaacttt
     2581 tgaccaatga gacctagctt aaggttttct tcaatacttt ggttttcaat taagccaaag
     2641 ttctggaaga ggtagcccaa ttcgtgacgg aaaaaatcac tcgatttata attggccaag
     2701 tctttacctc ggtaaaaaat cgtcccatca taagattcta atttcccaat catgttcatc
     2761 aaggttgttt ttccgctacc acttgaacca attaaggcat agacttttcc agcctcaaat
     2821 gtcattgaaa gattcgaaaa taactctcgt tctccaaaag atttactcac ctgtttaagt
     2881 tcaatcatat taacctccct ttaaaacaag catggacatc ttgttttctt tctgcatttg
     2941 gacatgtaac tgtaaaagag atagaccagt aaagagtaac gagactatga aagcaactac
     3001 tatctctacc ataagaaata cactcgcaac aaatcccagt aaaaacacac ccagttgagc
     3061 aaagagataa gtgcgatgga tttctaagaa ccttagacct gcaatgcgtt tgataaaaat
     3121 ggcacgtcta aattcttcaa agtagagcct attcatagtg ttaaacaaca agattgaagt
     3181 tgcaatccca agcacagctc ctgctagcat tacccaacgt tccctctgga tattatccaa
     3241 taatgtgatg tagttgtggt aacctgtttg catttctgag acccaatttt caatgccttg
     3301 tctctggata agctcctggg catcagacaa ttgattaaag agaacgtagt tctgtactgc
     3361 gtctacccaa aagaaaatgg actgtggacc agttgattgg ggtgttataa caatgatgat
     3421 tggatctttc aaaaactgct ggtaagaaat aggggtcgta ttatacacaa aacgatcctg
     3481 acctgattcc aaataaccta ccgtagcagt catttgctgt cgttcatctc gactagacac
     3541 gcgactggtt aagtcgtctt caaaaacaga tttataatgt tcttcctctg aacggaggtg
     3601 ttcaggcagc aataagacaa actcccctac atcaaggtga ttcatctttt gctcaatagt
     3661 tgtatctaca ggaatgtttt gacgctccaa gtattgcggt gtgacgataa ggacattgcc
     3721 attcgggctg taatcgtgcc attctgtaga ggttgtcaag tttttggagg aagccatgcc
     3781 attttgcaaa gaacggtcaa ttaactggtg tctagataag aaagcctttt tttctgaaac
     3841 agccagatcc atcaattgat accaagttct gagtttcctt tgagcttgtt catcaaaacc
     3901 aggactcgtt ccttcacggc tgaatgatag ggtaatcagt tgcctttcct ggctccaagc
     3961 ctcttgtcca atccgatgct gttgccaggc ttgggaatac tttaagctac tccctattcc
     4021 cagcgttaca ataataatcg ctaatagttg accgattaaa atcaaactaa tgattcctct
     4081 gacaggcact tgccctttta taatctgcat caagtgtatc ttttttattc caactgcgaa
     4141 gagttgagcg aaaaacaggg agaccgacaa caagatgaga ttataactga gcaagccttc
     4201 tcctatggtc attagggatt gcgttggaag cgacagaatt ttttgcataa gaatggcgag
     4261 cacgccagct aaactgaaac caacagctat ccctttcaaa tcctcaccaa ctggtctaag
     4321 gaaaatggac caccgtttct ctcctgaaat gaggcgaatg cccgacgaac gtaattggct
     4381 aatttgacta attaaagtca gtgctccaaa ggttaagatg aaaatcaata aaccgattaa
     4441 ttgaaatccg ttactaaaga tagccattaa cgtagatagt ttagatggaa ttatcaggtg
     4501 catgttagtc aagccaagtt gacttagctc ctctcttagc aagtgaatat ctaggtttcc
     4561 atcgaataca aaatagtttg tttcaacact actactttga gcatcttcta gatttttttc
     4621 ctgtagccca tcaggcaact ttccgttccc aaaggtcgta taagaaaaca ctggagtacc
     4681 ttctgagtta agatcctggt gttgaatcgc aataaagcta tccgtttctt ctgctagttt
     4741 ttccaagcgt gtagcaacat gctgaaaagt tgtttcaggg gaagaatcac gtacaacaac
     4801 gttggggtaa taatgggaga catatgtatc agtccaaatg gtaaataccc aaacaaagaa
     4861 caaactagca agcaggttgg atatgagtat aaataatttt ttcatagtgc attccttatt
     4921 ctaaaataga gggcagaaat acccctgccc tctataaact aacaagctta ctaaactatt
     4981 gataaaagaa tcttcttcaa ttattcttgc aatcccgcat caaatgtaac ttgctcccca
     5041 aaatttgtat taacaaacgc ataggccgca ctatgtgctc ctgcataagc tgttttttga
     5101 ttgtcacgtc cattacttcc aacataggcc cagtgatcct ctgaaccatg ataataattc
     5161 gaaaatgctc cccaattatt tggatcatga tagcctccat aggtccactc gccaccatgg
     5221 agagaaactg ccaaaacagg aagagccaaa ctacatgcca aaacggcaag ggatgatgca
     5281 actacttttc taaattttaa catattatta ctcctctgaa tgaaatatta tgaaaatgag
     5341 cgaaatgcaa ctacatattt taattagaaa tctcagtctg aattatagta tcctattttt
     5401 tcctcctttc taactgcacg ttcctttcta caggcagaga cctaatttta taaaccaatc
     5461 ttaaatactt tagattttgt aactcataat tttcaacagt tggttagcta tgaaagcatt
     5521 ttatcaaaca tctccattct tatatctatc tggtattgtt acaagctctc ataagaatac
     5581 ctttctctaa atagttgaat tttaaagtaa tacgaaatca atctgccttc ccaacatcaa
     5641 gaccattgga attcttttgt aattgcactc gaatctccaa tcgtttattc atctgaacaa
     5701 actgttggta agaaattgtg ttactaaacg taaaaacacc tagtaatact aatatagcta
     5761 atttttgaat tccacgattt ttctttattc gtgaaacccc tttctgtttc cttgttttta
     5821 ttttaacata tgtatattat tcagtcaagt atttttatta tattttgaac tttttttatt
     5881 atttctattt gtaattttat cgagcaaata tttgccgtct ttaactaaat gatatataat
     5941 tgacaaatat aaattaggaa ggttttttgt ttttatgact acattagctg aaaaattcag
     6001 attgaaaaga aaagagttga gactctccca acaaactctt gcagaaggaa tttgtgaaca
     6061 agaatatgag gtaaactact ttcatttaat ggagttatat cagacaaaaa attttgagca
     6121 tcaagagttt ttatttggct acatcagagt tcgttacaac tacgctcact acctagtatc
     6181 aaaggaaaaa tataacgaag ccatccaaga agctcttgag acgattgaac tctgtaaaca
     6241 aagacagaca agctaccaac tggctcccct acttattctt gtaggaaatg ctggagccaa
     6301 atttctagat aaagaacaag tcaaaaatta ttatatagaa gcaagagagt tatgtaagat
     6361 ttataacaat cctttaatgt tgatgaagat agaaaactat ttgaaggaat tagatattgt
     6421 ttagttaatc ttgacattat agtttttctg aaacgttaaa taacctgtaa ggctgatagt
     6481 gagattaata ctatcagtca cataaataaa aaaccttatc cgaatttaga ttcagataaa
     6541 gtcttttaac tacctaaaaa gttcacattt tttccttatt cattgagtta atgaagcgcc
     6601 aactgaatcc tagaacccac atcagattga tgaaaaggta cacagccgta aaactagtta
     6661 aaccatgttg tctgatatca tcaaaatata aactaggttc agtaaagaac aaataaattc
     6721 catagacctc tacgaaaata agaaaactga caaaaccaat aaggaaaagt ccactggcaa
     6781 taagaaagag tctccataaa agaatgagaa ttcctcctac tgctaaaaaa attactggga
     6841 taaggagtaa atcattcatg actttctcct ctctagtcaa tcaattgacg ataatgggtg
     6901 gcaagagagg aatcaaattc ctctagcttt tgaactaagt ccaaatactc ctctttttca
     6961 tgttcttcaa agtccacacc tcgatgattc tgaagagcga tttccaattg gctagtaagt
     7021 tctcgtttgg aaaagctgta atcccctgtc acttcctcat aatgttcctt taactccttg
     7081 taggcttgat attcttcagg tgtttgaaat ccctgtatta aggcctcttc taactgataa
     7141 taggtatctt ccatcataat tgttacctcg tttctttcta tctttattct accgcgcttt
     7201 tcttttcttg tccgctattt atatctattt tttaatctaa ttcaaaagaa agttgttctt
     7261 ctttttcttt tcctttttcg tggaattgtc ttaaggcctg atcaataata tctaaatccg
     7321 tttctgtttc aatcaatggc gcgagtacat cgtattcggc ctttttagtt tgataatcct
     7381 cttcctttgg aaaattattt tcaatttcta ccttagcagt agtccattta tcctttaatt
     7441 catccaataa gttctgagtt ttcacttggt cctctttaat gtgatcaatc gtatgctgaa
     7501 gcctttgaat tgtccccaaa ggagaataca aatctaaact gacagaatat tgattttctc
     7561 ctacaatctt aacagagaag gtttcaggaa gaggttgatt tattggaaga ctaagcattt
     7621 taatgtcaaa tcctcgatag cttgctaggg ttcgaaattc tttgctgtca gcttgattat
     7681 gacggataag acggtgtaag gattcccctg cttcagatcg ttgatcaaaa gcttgcttac
     7741 ctaccgtcat agaaaatgcc tggtctttcg atatttcaga ctgttgaata tcgccttcat
     7801 acttgcttaa tcgtttctca agaatgggca tattttcttc acagtaagag attgtatgac
     7861 gatagtgatc cttgctgcgt tgaaaggcgc gtctttgatt ttctaataga gttagatcat
     7921 tctctatttc catcttatat ttgagataag gattacctgt tgctaatgcc ttaaaatccg
     7981 aagctgtcat agtctgctca tcaatgtctt ctgcagcacg aatcggctcc ttagaagtca
     8041 taatctgctt aatataacgg agtttgttct cctgagttgc ccatagataa ttatcaaacg
     8101 aacctttggt aatatagtgg taaatatcta cttccttgtt ttcatttccc tgtcggatta
     8161 tacgtccatt gcgttgtagg ctaagtaccc agcgccttac catattacta cggcaggttt
     8221 ccaaatactc gcccccgaac cgtacgtaca cctttcaatg tatacggctc tccgtttata
     8281 aactcaatct aacttgccat gatgtaattt cttatggcaa tctttacaca gtgctattgt
     8341 tttccgttgt ctagaaatca tcaaacgttc ccaaaaagtc tttcccttta aatcctttag
     8401 ttttctcaca tgatggattt ctagggaact gtcggtcgct tgacaatact cacaacggct
     8461 tgcttttaat ctatcaatta aatttgttcg actaaaatat ttcgccgtat ttggcaaatt
     8521 atcattgtca aggaaagatt tcttttgacg tttaaatcct ccgttataga aataacgggt
     8581 cattgtatcc cctttacgtc caatatactg taccctaaat tgaccatcct ttttatattt
     8641 acggatgatg tgggatttag tcgtacgata tttagtcgca taagttttat acatgctata
     8701 ttccatgatg tacttaaagc gatgaaggat agagctgtta ttagcgatac aataatagtt
     8761 ataaaaacct cttatttctg cattgtagcg ttctagaatc tctaaatcat cgcaatcttt
     8821 catgaaataa cgggccgttg gtttccaaac ttcgtagcct ctatgataag tcattttcat
     8881 agctccgtaa gacagtaatc tgtctcgaat tgtttcaata gaaacctcta ggactaatct
     8941 acctgtataa tttctgacca atcgtcctgc cgaatcacgc ttagctaaat tcgattggcg
     9001 aatatacaga tgatatccca gaaacttagc tttatctctc gcattggtaa tcaaggtttt
     9061 ctccacagag agttccaatt tgagaactgc ctccaaatag tccttaatat ctgctttaat
     9121 gcgaagagcg tcctctttac tgccaatcac accgcagata aaatcatctg cgtatcgggt
     9181 gtaggttaga cgtttaaaac tactatccat aggatcacta tgaggaatta acactctttc
     9241 cttttccaat tgacgaatac gctggataac ttcttgtcgt tgattttccg ttgaaacata
     9301 ttctaatgct cttcttgctt ttcccaactc tatctcattc tggcgatatt ctggggtacg
     9361 tttccggtat ttcccttggc agaagttctt cacataatcc gtcatatatt tatcaaactt
     9421 atccaaatag atattggcta aaatgggact gattatccct ccttgtggag ttcctgagta
     9481 ggttttgtag aatttccaat cttccacgta tcccgcattg aggaatttac gaatcaagcg
     9541 taagaaccgc tcatcagtaa ttctttctcg gagaatgtga atcatcacat catgattgat
     9601 attatcaaag aatgacttga tatctccttc aataaaccat tttgttccag tgtaggtctt
     9661 ctgaatctga gtaagtgctg tatggcaact tttattcgga cgaaaaccat gggaagaggg
     9721 ttcaaattgt ccctcgtaga tagcttccaa aatcatttta ataacctgtt gtaagagctt
     9781 atcatcaaat gatggaatac ctagtggacg tagcttccca ttctttttag gaatataggt
     9841 tcgtcttgat gggtgtggct gataggattc atctttcagg gaatcaatca attggtcaat
     9901 tctagctata ctcataccat caatcgtcaa ctcgtctact ccaggtgtca agtgtcctgg
     9961 gttagcgtaa atcgtttgat aggcaactaa gtacatttct ttgttataaa gcaaacgata
    10021 cagtcgctca aattgatagt ttttatcttt actgtgtttt gttagattgt ttaacacatt
    10081 ttgaggattt ctcatggtgt ctcacacacc ttcctttcca taatgttaat gttataaact
    10141 gttccccttc gccatgtacg tgccattaac acgctcggac tactatggga actccgttac
    10201 cttatcaaat attcataaac cttatgttta atagctttta caagcgtttt gacttaggta
    10261 atctccgttt agctggtata gtaacatagc ttgataattt cat
//
