LOCUS       c00001_NZ_JYGP..       12154 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JYGP01000001.1 Streptococcus mitis strain OT25 TZ90_contig000001,
            whole genome shotgun sequence.
ACCESSION   NZ_JYGP01000001
VERSION     NZ_JYGP01000001
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:52:31
            Original ID  :: NZ_JYGP01000001.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 32745
            Orig. end    :: 44899
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12154
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[37745:39899](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7154
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12154
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12154
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             592..1938
                     /locus_tag="ctg1_28"
                     /transl_table=11
                     /translation="MIILEFLVSVLYILLVVVSTMVPTIYLGAQISPEFYKKRYWILIF
                     LISLSARQTFGELFHIGVLIYFYCIFLLVLHKGKGESLFLSLYLFLFFQSIRYLFLTIW
                     IRVLSGEHCCFVDSFSTLYISIFDLLSIFLCCKIMKRWSLDLDLFFSDTFKTHYRKSFF
                     IILPLTGFRIFSSFMTNRNSSFYVRFDTTISLLIFILFFSWLFYIRHLEQVYRDEQTIQ
                     RQEEENRSLQGMVDKLGHLYDEVRGFRHDFAGIVASMEPAIANQDMAEVSTIYQDVFLK
                     TNEKLRKADYTAFNLHNIHDIAIRNTLAKAMIVADKQGIHFSLETVGVVEELALPMLEA
                     IRILSILTTNALEAASEAENPQIRVALLASDRSVRFIIENTRKKEELNPSILSQKGYST
                     KGNHSGLGLATLEDMVFHYDLNLDTQLGEMTFRQDLELPFKDEKRGGEE"
     PFAM_domain     1609..1902
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_28_0001"
                     /evalue="5.10E-11"
                     /label="ctg1_28"
                     /locus_tag="ctg1_28"
                     /protein_end="437"
                     /protein_start="339"
                     /score="42.5"
                     /tool="antismash"
                     /translation="AIRILSILTTNALEAASEAENPQIRVALLASDRSVRFIIENTRKK
                     EELNPSILSQKGYSTKGNHSGLGLATLEDMVFHYDLNLDTQLGEMTFRQDLEL"
     CDS             1935..2666
                     /locus_tag="ctg1_29"
                     /transl_table=11
                     /translation="MRILVLEDDRVQQGRIEQTLLDIGRSRNLRLEIDIAKNYGDVEKY
                     SQYFDHYQLYLLDLEIDGERERGFQVAQQVRERDPFTSIVFVSTHSEALPLAFRYHLSA
                     LDFISKDQPEEDYRHQLERCLDYVLAVDKRENMRLFTYSFEGRRGFTLPYHEILAFETS
                     VESHRIKVYYANHSIKTIYGSLKDIAAKAEKDYFVYANRNTLVSLQAIEEMTATEVTLL
                     EGLHFPVSRTARRTLKKHLNV"
     PFAM_domain     1941..2291
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_29_0002"
                     /evalue="4.50E-09"
                     /label="ctg1_29"
                     /locus_tag="ctg1_29"
                     /protein_end="119"
                     /protein_start="2"
                     /score="36.6"
                     /tool="antismash"
                     /translation="ILVLEDDRVQQGRIEQTLLDIGRSRNLRLEIDIAKNYGDVEKYSQ
                     YFDHYQLYLLDLEIDGERERGFQVAQQVRERDPFTSIVFVSTHSEALPLAFRYHLSALD
                     FISKDQPEEDYRH"
     PFAM_domain     2382..2657
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_29_0003"
                     /evalue="1.00E-12"
                     /label="ctg1_29"
                     /locus_tag="ctg1_29"
                     /protein_end="241"
                     /protein_start="149"
                     /score="48.2"
                     /tool="antismash"
                     /translation="FTLPYHEILAFETSVESHRIKVYYANHSIKTIYGSLKDIAAKAEK
                     DYFVYANRNTLVSLQAIEEMTATEVTLLEGLHFPVSRTARRTLKKHL"
     CDS             3106..3303
                     /locus_tag="ctg1_30"
                     /transl_table=11
                     /translation="MTNFDKMEQNFVALTEEELMNVDGGIAPIIIGGVVIGWKLIGGVA
                     ALATVSAGAGIAAGYYANRP"
     aSDomain        3136..3285
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_30_0001"
                     /evalue="3.30E-11"
                     /identifier="TIGR03949"
                     /label="ctg1_30"
                     /locus_tag="ctg1_30"
                     /protein_end="60"
                     /protein_start="10"
                     /score="40.8"
                     /tool="antismash"
                     /translation="FVALTEEELMNVDGGIAPIIIGGVVIGWKLIGGVAALATVSAGAG
                     IAAGY"
     CDS             3517..3672
                     /locus_tag="ctg1_31"
                     /transl_table=11
                     /translation="MDKFQVVDEKDLQVIEGGIEPISIIFGLSAIAFGAFGAGYTFGSD
                     LARRGR"
     aSDomain        3526..3645
                     /aSDomain="TIGR03949"
                     /aSTool="tigrfam"
                     /description="bact_IIb_cerein: class IIb bacteriocin,
                     lactobin A/cerein 7B family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_31_0002"
                     /evalue="1.60E-08"
                     /identifier="TIGR03949"
                     /label="ctg1_31"
                     /locus_tag="ctg1_31"
                     /protein_end="43"
                     /protein_start="3"
                     /score="32.2"
                     /tool="antismash"
                     /translation="FQVVDEKDLQVIEGGIEPISIIFGLSAIAFGAFGAGYTFG"
     CDS             3972..4151
                     /locus_tag="ctg1_32"
                     /transl_table=11
                     /translation="MKTFLLGFAEGYFTVSLIIYIATYLILKNPINTLFYPEIYPVLFG
                     LFYLGYKVNKKQVE"
     CDS             4230..4436
                     /locus_tag="ctg1_33"
                     /transl_table=11
                     /translation="MKFVKSILKVWPEIMVLLSSMSYIIIRLVADMNKVSLPTWFDSFN
                     IPTIALFMMVFILLYRSKEKKNR"
     CDS             5001..7154
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 332.3; E-value:
                     9.7e-101)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_34"
                     /sec_met_domain="TIGR01193 (E-value: 0.0, bitscore: 1126.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.1e-42, bitscore:
                     138.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFSKRHYRPQVDQMDCGVASLAMVFGYYGSYYYLAHLRELAKTT
                     MDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQD
                     KDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPILVK
                     QRGLIANIVLATLLVTMINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQIL
                     SYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALAS
                     TILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEAN
                     AVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAH
                     LLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRL
                     NEVYLVASEFEEKKTVEDLSLMKGDMTFKQVSYKYGYGRDVLSDINLTIPQGSKVAFVG
                     ISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKTLRQYINYLPQQPYVFNGTILE
                     NLLLGAKEGTTQKDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARA
                     LLTDAPVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGK
                     IVEEGKHADLLAQGGFYAHLVNS"
     PFAM_domain     5019..5426
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_34_0004"
                     /evalue="1.00E-40"
                     /label="ctg1_34"
                     /locus_tag="ctg1_34"
                     /protein_end="142"
                     /protein_start="6"
                     /score="138.7"
                     /tool="antismash"
                     /translation="HYRPQVDQMDCGVASLAMVFGYYGSYYYLAHLRELAKTTMDGTTA
                     LGLVKVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHI
                     ADPDPGVKLTKLPRERFAEEWTGVTLFMAPSP"
     aSDomain        5031..7148
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_34_0003"
                     /evalue="0.00E+00"
                     /identifier="TIGR01193"
                     /label="ctg1_34"
                     /locus_tag="ctg1_34"
                     /protein_end="716"
                     /protein_start="10"
                     /score="1126.7"
                     /tool="antismash"
                     /translation="QVDQMDCGVASLAMVFGYYGSYYYLAHLRELAKTTMDGTTALGLV
                     KVAEEIGFETRAIKADMTLFDLPDLTFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPD
                     PGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPILVKQRGLIANIVL
                     ATLLVTMINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLV
                     LGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVS
                     TVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKMNRDTMEANAVLSSSIIED
                     INGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHLLLNVGILWM
                     GAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEF
                     EEKKTVEDLSLMKGDMTFKQVSYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLA
                     KMMVNFYDPSQGEISLGGVNLNQIDKKTLRQYINYLPQQPYVFNGTILENLLLGAKEGT
                     TQKDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLIL
                     DEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADL
                     LAQGGFYAHLVN"
     PFAM_domain     5508..6314
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_34_0005"
                     /evalue="3.10E-62"
                     /label="ctg1_34"
                     /locus_tag="ctg1_34"
                     /protein_end="438"
                     /protein_start="169"
                     /score="210.8"
                     /tool="antismash"
                     /translation="NIVLATLLVTMINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVI
                     VYILQQILSYAQEYLLLVLGQRLSIDVILSYIKHVFHLPMSFFATRRTGEIVSRFTDAN
                     SIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTVIIFAFMKPFEKM
                     NRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQ
                     KALKKVAHLLLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPL"
     PFAM_domain     6498..6950
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_34_0006"
                     /evalue="1.60E-31"
                     /label="ctg1_34"
                     /locus_tag="ctg1_34"
                     /protein_end="650"
                     /protein_start="499"
                     /score="109.8"
                     /tool="antismash"
                     /translation="LSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLG
                     GVNLNQIDKKTLRQYINYLPQQPYVFNGTILENLLLGAKEGTTQKDILRAVELAEIRED
                     IERMPLNYQTELTSDGAGISGGQRQRIALARALLTDAPVLILDEATS"
     aSDomain        7167..8513
                     /aSDomain="TIGR01000"
                     /aSTool="tigrfam"
                     /description="bacteriocin_acc: bacteriocin secretion
                     accessory protein"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_35_0004"
                     /evalue="3.10E-171"
                     /identifier="TIGR01000"
                     /label="ctg1_35"
                     /locus_tag="ctg1_35"
                     /protein_end="449"
                     /protein_start="0"
                     /score="568.2"
                     /tool="antismash"
                     /translation="MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFAIFAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGELLVQYQEGAEGVQAEAYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYLSQAASLRASTSQQNETI
                     ASQNAAASQTQAEIGNLIRQTEAKIRDYQTAKSAIETGASLASQNLAYSLYQSYKSQGE
                     ENPQAKSQAVAQVEAQLSQLESSLATYRVQYAGSGTQQAYASGLSNQLESLKSQHLAKV
                     GQELTLLDQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSTMVAEGTLLAQL
                     YPSLEKEGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     CDS             7167..8516
                     /locus_tag="ctg1_35"
                     /transl_table=11
                     /translation="MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFAIFAEKEM
                     SLSTRATVEPSRILANIQSTSNNRILVNHLEENKLVKKGELLVQYQEGAEGVQAEAYAS
                     QLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYLSQAASLRASTSQQNETI
                     ASQNAAASQTQAEIGNLIRQTEAKIRDYQTAKSAIETGASLASQNLAYSLYQSYKSQGE
                     ENPQAKSQAVAQVEAQLSQLESSLATYRVQYAGSGTQQAYASGLSNQLESLKSQHLAKV
                     GQELTLLDQKILEAESGKKVQGNLLDKGKITASEDGVLHLNPETSDSTMVAEGTLLAQL
                     YPSLEKEGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTE
                     KGNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE"
     CDS             8644..9393
                     /locus_tag="ctg1_36"
                     /transl_table=11
                     /translation="MVECAQVIRKANFKMSKQLIYSGKAKDIYTTEDENLIISTYKDQA
                     TAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKNVKIIPLEV
                     VLRNYTAGSFSKRFGVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAY
                     LKEETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHM
                     DKDVFRRGLGELTDVYEIVWEKLQGLK"
     aSDomain        8689..9336
                     /aSDomain="TIGR00081"
                     /aSTool="tigrfam"
                     /description="purC:
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_36_0005"
                     /evalue="6.50E-72"
                     /identifier="TIGR00081"
                     /label="ctg1_36"
                     /locus_tag="ctg1_36"
                     /protein_end="231"
                     /protein_start="15"
                     /score="240.2"
                     /tool="antismash"
                     /translation="SKQLIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKG
                     VLNNQISSFIFEKLNAAGVATHFVEKLSDTEQLNKNVKIIPLEVVLRNYTAGSFSKRFG
                     VDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKVW
                     FAEIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGL"
     PFAM_domain     8701..9363
                     /aSDomain="SAICAR_synt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01259.20"
                     /description="SAICAR synthetase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_36_0007"
                     /evalue="9.10E-66"
                     /label="ctg1_36"
                     /locus_tag="ctg1_36"
                     /protein_end="240"
                     /protein_start="19"
                     /score="222.1"
                     /tool="antismash"
                     /translation="IYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNN
                     QISSFIFEKLNAAGVATHFVEKLSDTEQLNKNVKIIPLEVVLRNYTAGSFSKRFGVDEG
                     IALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEETRRINELLKVWFAEI
                     GLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDADGNHMDKDVFRRGLGELTDVYEI"
ORIGIN
        1 cagatggtcg tagagtatta ccacttccag agatgacaac tagatcagaa atcaaaaaag
       61 ttggcaatga tctttatcta gaagacccag gtgtacgact tagacttccg tctacttact
      121 tcacaatcaa taacaataaa ctatactatt tagaaaatga acaaggtaag cttaaaacag
      181 gttactttgt actgattgat gatggagcaa ccactactca ctatcacatt ctagcctatg
      241 cggatcaatc cggtgagatt cttaagatga aacgcttgcc atcaggattt tcagattatt
      301 ttgacaaaga aatcgatggt ttctatggtc aaaaaattaa gattacacag ccaaataagt
      361 atgaatatta caaggttctt gtggtaaaat aaatagataa gcaatcttca caacgaatat
      421 aaaaaataaa acgtgcaaat cattttcaag aggctttaga tttcttgtat tttaaaagaa
      481 actaaagcct tttgtggatg tatcgttttt cagaaagtat gaaaaactag agagttgtat
      541 cggggagata aatattattt cgcttaaata aattaggagt cgttttattc tatgattatt
      601 ttagaattct tagtttctgt gctatatatt ctgttggtag tcgtttcaac catggtgcct
      661 actatttatt tgggcgctca aatttcccca gaattttata aaaaacgtta ttggatactt
      721 atatttttaa ttagtttatc tgctcgtcaa acatttggag aattatttca tataggagtt
      781 cttatctact tttactgtat ttttttatta gtattgcaca agggaaaagg ggaatctctt
      841 tttctttctc tgtatctttt tctcttcttt caaagtattc gttatttatt tttgacaatt
      901 tggattcgtg tattatctgg tgagcattgt tgtttcgtag attcgttttc tactttatat
      961 atatctatat ttgatttatt atcaatcttt ctatgttgta aaattatgaa gcgttggtct
     1021 ttggatttgg atttattctt ttcagatact tttaaaaccc actatcgtaa gagttttttc
     1081 attatcctac ctctgactgg atttaggata ttctcttcgt tcatgaccaa tagaaatagt
     1141 tctttttacg ttcgctttga cacgaccatt tctctcctga ttttcattct ctttttctcc
     1201 tggctctttt atatcagaca cttagagcag gtttatcgtg atgagcaaac cattcagaga
     1261 caggaagaag aaaatcgttc cttgcaaggg atggtggaca agctgggtca tctctatgat
     1321 gaggttcgag gtttccgtca tgattttgcg ggaattgtcg ccagtatgga gcctgctata
     1381 gctaatcaag atatggctga ggtgtctacc atttatcaag atgtctttct aaagaccaat
     1441 gaaaagctga ggaaggcaga ttacacagct tttaatctcc acaatatcca tgatatagcc
     1501 attcgaaata ccttggcaaa agccatgatt gtggcagata agcaaggaat tcattttagt
     1561 ttggagacgg tgggggtcgt agaagagctg gctttgccga tgttggaggc tatccgtatc
     1621 ctctctatcc tcacgaccaa tgccttagag gcagccagtg aggcagaaaa tccgcagatt
     1681 cgggttgctt tgttggcaag tgataggagt gtccgtttta tcattgaaaa cactcgtaag
     1741 aaagaagaac tgaatcccag cattctcagt caaaagggtt attcgaccaa gggtaaccac
     1801 agtggactgg gcttagcaac cttggaggac atggtttttc attatgattt gaacttagat
     1861 actcagctag gagagatgac ctttagacaa gatttagaat tgccatttaa ggatgagaaa
     1921 cgagggggag aggaatgaga attttagttt tggaagacga tagagtccag caaggacgga
     1981 tagagcagac tttactagat attggtcgct ctcgcaattt aagattggaa attgatattg
     2041 ccaaaaacta tggggacgtt gaaaagtatt ctcagtattt tgatcattac cagctctatt
     2101 tattggattt agaaattgat ggagaacgtg aacggggctt tcaggttgct caacaggttc
     2161 gggagcggga tccttttaca agcattgtct ttgtgtccac gcactcggag gccttgcctc
     2221 tagcttttcg ctatcacttg tctgccttgg attttatttc caaggatcag ccagaggaag
     2281 attaccgtca tcagttggag cgctgtctgg actatgtact ggcagtggac aagagggaaa
     2341 atatgcgtct cttcacctat agttttgagg gaagacgggg ctttactctg ccctaccatg
     2401 agattttagc ctttgaaacc tcagtggaat cccatcgtat caaggtctat tatgccaatc
     2461 attctatcaa gaccatttac ggcagtctta aggatatcgc tgccaaggct gaaaaagatt
     2521 actttgtcta tgcaaatcgc aatactttag tcagtttaca ggcaattgaa gagatgactg
     2581 cgacagaagt gaccttgtta gaaggcttgc attttcccgt atcacggaca gccagaagaa
     2641 cccttaaaaa acatctcaat gtctaatatc tgttagactt ggatgagttt atcaataaga
     2701 atgtcggaaa attttctgat attcttattt ttttgacttc tttttcgaat agataggtaa
     2761 gaggaaaagg aaaggagttt gcttcatgta tctaccaatt ttctattcat ggtacattaa
     2821 attatttttc aaataaattt aatttagttg tacattttcg aaattttttt cgaatagata
     2881 agtaagagga aaaggaagga gactacgcga tgtatttacc aatcttattg ccatggttta
     2941 tcaaatggta tttaaaataa atgaaatcta cctgttcatt ttaaatcact tctcaaatag
     3001 ataagtgaga cgaaaaggaa ttcagtaatt tatctattct ggtttttaaa atggtttaag
     3061 agccagaaat cgtaaactaa aaaatagaaa taaaggagaa aaaagatgac aaattttgac
     3121 aaaatggaac agaactttgt agctcttaca gaagaagagt tgatgaatgt agatggagga
     3181 attgcaccaa ttattattgg tggtgtagtt attggttgga aattaattgg aggtgtagct
     3241 gcgcttgcta cagtttcagc aggtgcgggt atagctgcag gatattatgc taatcgacca
     3301 taattttgta gatatatatg aaatttgtta aattaatgtt gaagatttgg cctgagctta
     3361 tggtattact tagttcaata tcttatacaa ttatcaggtt ggtagctgat gtgaataagc
     3421 tacccttacc tacatggttt gatgatttta atataccaac aatttcattg tttttaatgg
     3481 tattcatttt attatataga agtaaaggag aaaagaatgg ataaatttca agtagttgat
     3541 gagaaagatt tgcaagtaat tgaaggagga attgaaccta tttcgattat atttggccta
     3601 agtgctattg catttggcgc atttggggct ggttacacat ttggttcaga tttggctcgt
     3661 cgtgggcgtt agataatgaa taatcgcaac cttaatctca atacattgtt acctaaacta
     3721 gccacgatat ttcctttgtt gggaataact cttaatgtcg cgcttcatgt gattcgtaca
     3781 ggttcgttag tatcctttaa ttggcaatgg actttggtag gtttgctttt cgcaggatat
     3841 tttggtattt ttcgcaaaga tttgtcaaaa aataatcaaa gatataaatg atgaatctga
     3901 atcaaaggga ttttgtgcat gtgaatggca gaactttccg ccatttctta tcaggtaaat
     3961 aggagtctaa catgaaaaca tttttattag gttttgctga gggttatttt accgtatcgc
     4021 tcataatcta catcgcaacg tatttgattt tgaaaaatcc aatcaatacc ctattttatc
     4081 cagaaattta ccctgtttta tttgggctct tttatctagg atataaggtc aataaaaagc
     4141 aagtagagtg agcagttaag aatgacttgt tagtctgcac tgaaaatggt tagggtagaa
     4201 tctaagaatg catcacattg gagtttaata tgaaatttgt taaatcaata ctgaaagttt
     4261 ggcctgaaat catggtatta cttagttcaa tgtcttatat catcatcaga ttagtagctg
     4321 atatgaataa agtatcttta cctacttggt ttgatagttt caatatacca acgattgcat
     4381 tatttatgat ggtcttcatt cttttataca gaagtaaaga aaaaaagaat agataaattt
     4441 gaagcagtag atgctctata gggaataggt gttttatagt aacgaatcaa aaaaggagta
     4501 actatgaatc gtaatttaga acggtgttat ctattctgac taggaatagg tcataccaga
     4561 ggtggcttag aaatagcagg gacattagaa attgtagtaa taaataggat gtcgtaaatg
     4621 ttactatcaa tgatttattt gttccaagat tgcctaggat gacagtaaaa catcaatttc
     4681 ctttcatacc atatttttag taggtaggac gtttgttctg cctatttttt tatccaaaaa
     4741 gtgcagttgg gagggagata ggcgcatttg gggaggaagt ccagtttttg tttggggatt
     4801 ggggtaagat agttgttatc agatgagttt atactcttcg aaaatcaaat tcaaaccacg
     4861 tcaacgtcgc cttgccgtgt agatgttact gacttcgtca gttctatcta caacctcaaa
     4921 gccgtgcttt gagcaacctg cggctagctt cctagtttgc tctttgattt tcattgagta
     4981 ttaggaaaaa ggagatgaat atgaaattta gtaaacggca ttatcgtcct caggtagacc
     5041 agatggactg cggtgtagct tcattagcca tggtttttgg ctactatggt agctattatt
     5101 atttggctca cttgcgagaa ttggccaaga caaccatgga tgggacgacg gctttgggct
     5161 tggtcaaggt ggcagaggag attggttttg agacgcgagc cattaaggcg gatatgacgc
     5221 tctttgattt gccagatttg acttttcctt ttgttgccca tgtgcttaag gaaggaaaat
     5281 tgctccacta ctatgtggtg actgggcagg ataaggatag cattcatatt gccgacccag
     5341 atcctggggt gaaattgacc aaactgccac gtgagcgttt tgcggaagaa tggacaggag
     5401 tgactctgtt tatggcacct agtccagact acaagcctca taaggatcaa aagaatggcc
     5461 tgctctcttt tattcctata ttagtgaagc agcgtggctt gattgctaat atcgttttgg
     5521 caacactctt ggtaaccatg attaatattg tgggttctta ttatctgcag tctatcattg
     5581 atacctatgt gccagatcag atgcgttcga cgcttgggat tatttctatt gggctagtta
     5641 tcgtctatat tctccagcag atcttgtctt acgctcagga gtatctctta cttgttttgg
     5701 ggcaacgctt gtcgattgat gtgattttgt cctacatcaa gcatgttttt cacctgccta
     5761 tgtccttttt tgcgacacgc aggacagggg aaatcgtgtc tcgtttcacg gatgctaata
     5821 gtatcatcga tgcgctggct tcgaccattc tttcgatttt cctagatgtg tcaacggttg
     5881 tcattatttc ccttgtttta ttttcacaaa ataccaatct ctttttcatg accttattgg
     5941 cacttcctat ctacacagtg attatctttg cttttatgaa gccgtttgaa aagatgaatc
     6001 gggataccat ggaagccaat gcggttctgt cttcttctat catcgaggac atcaatggta
     6061 ttgaaactat caagtccttg accagtgaaa gtcagcgtta ccaaaagatt gacaaggaat
     6121 ttgtagatta tctgaaaaaa tcctttacct atagtcgagc agagagtcag caaaaggctc
     6181 tgaaaaaggt tgcccatctc ttgcttaatg tcggcattct ctggatgggg gctgttctgg
     6241 tcatggatgg caagatgagt ttgggacagt tgattaccta taataccttg cttgtttact
     6301 ttaccaatcc tttggaaaat atcatcaatc tgcaaaccaa gcttcagaca gcgcaggttg
     6361 ccaataaccg tctgaatgag gtttatctgg tagcttctga gtttgaggag aagaaaacag
     6421 ttgaggattt gagtttgatg aagggagata tgaccttcaa gcaggtttcc tacaagtatg
     6481 gctatggtcg agacgtcttg tcagatatca atttgaccat tccccaaggt tctaaggtgg
     6541 cttttgtggg gatttcgggg tcaggtaaga cgaccttggc caagatgatg gttaattttt
     6601 acgacccaag tcagggagag attagtctgg gtggtgtcaa tctcaatcag attgataaaa
     6661 agactctgcg ccagtatatt aactatctgc ctcaacagcc ctatgtcttt aacggaacga
     6721 ttttggagaa tcttctcctt ggagccaagg aagggacgac tcaaaaggat atcttacggg
     6781 cggtcgaatt ggcagagatt cgggaggaca ttgagcgcat gccactgaat taccagacag
     6841 aattgacttc ggatggggca gggatctcag gtggtcaacg tcagagaatt gctctggcgc
     6901 gtgctctctt gacagatgcg ccggtcttga ttttggatga ggcaactagc agtttggata
     6961 ttttaacaga gaagcggatt gtcgataatc tcatggcttt agacaagacc ttgattttca
     7021 ttgctcaccg cttgaccatt gcagagcgga cagagaaggt ggttgttttg gatcagggca
     7081 agattgttga agaaggaaaa catgctgatt tgcttgcaca gggtggtttt tacgcacatt
     7141 tggtgaatag ctagaaagag gagagaatga aaccagaatt tttagaaagt gcggagtttt
     7201 ataatcgtcg ttaccataat ttttccagtc gggtgattgt ccccatgtcc cttctgctcg
     7261 tgtttttact tggctttgca atatttgcag agaaggagat gagtttgtct actagagcta
     7321 ctgtcgagcc tagtcgtatc cttgcaaata tccagtcaac tagcaataat cgcattcttg
     7381 ttaatcattt ggaagaaaat aagctggtta aaaagggaga actgttggtt caatatcaag
     7441 aaggggcaga gggtgtccaa gcggaggcct atgctagtca gttggacatg ctcaaggatc
     7501 aaaaaaagca attggagtat ttgcaaaaga gtctgcaaga aggggagaac cactttccag
     7561 aggaggataa gtttggctac caagccacct ttcgcgacta tctcagccaa gcggctagtc
     7621 ttagggctag tacatcgcaa caaaatgaga ccatcgcgtc ccagaatgca gcagctagtc
     7681 aaacccaagc cgaaatcggc aatctcatca ggcaaacaga agctaaaatt cgcgattacc
     7741 agacagctaa gtcagctatt gaaacaggtg cttccttggc cagtcagaat ctagcctact
     7801 ctctctacca gtcctacaag tctcagggcg aggaaaatcc gcaagctaaa tctcaggctg
     7861 ttgcgcaggt tgaagcacag ctttctcagt tagaatctag tcttgctact taccgtgttc
     7921 agtatgcagg ttcaggtacc cagcaagcct atgcgtcagg cttaagcaat caattagagt
     7981 cccttaaatc ccaacatttg gctaaggtcg gtcaggaatt gacccttcta gaccagaaaa
     8041 tcttggaggc agagtcaggt aagaaggtac agggaaatct tttagacaag gggaaaatta
     8101 cggcgagtga ggatggggtg cttcatctta atcctgagac cagtgattct accatggtag
     8161 cagaaggtac cctactagcc caactctatc cgtccttgga aaaagaaggg aaagccaaac
     8221 taacagctta tcttagttca aaggatgtag caaggatcaa ggtcggtgat tctgttcgct
     8281 atacgacgac tcatgatgcc aagaatcaac ttttcctaga ttctactatt acaagtattg
     8341 atgcgacagc tactaagact gaaaaaggga atttctttaa aatcgaggcg gagactaatc
     8401 taacttcgga gcaggctgaa aaacttcgat atggggtgga aggtcgcctg cagatgatta
     8461 cgggcaagaa aagttaccta cgttattatt tggatcaatt tttgaacaaa gagtaatgtt
     8521 cgtattttta gagttaaatg attttaaaac tgtgagaaag atccttcttg cagttttttc
     8581 tttatgattt ttgaggttga tacgttattt attcggttaa attcttgtaa ttttaggttt
     8641 tttatggtag aatgtgctca agtaatacga aaggcgaact ttaaaatgtc aaaacaattg
     8701 atctattcgg gaaaagctaa agatatctat acaactgagg atgaaaatct tattatttca
     8761 acttacaagg accaggcgac tgctttcaat ggtgtcaaga aggagcagat tgcaggtaag
     8821 ggagtgttga ataatcagat ttcatctttt atttttgaga aattaaatgc ggctggtgtg
     8881 gcgactcact ttgtggagaa gctttcggac acggaacaac tcaataaaaa tgttaagatt
     8941 attcctttgg aagttgtgct ccgcaactat actgctggtt ccttttcaaa acgttttggc
     9001 gtagacgaag gaatcgcctt ggagactccg attgtcgaat tttactacaa aaatgatgat
     9061 ttggatgatc catttatcaa tgatgagcat gtgaaattcc tacagattgc cgatgatcag
     9121 cagattgcct acttgaagga agaaactcgt cgtatcaatg aacttttgaa ggtctggttt
     9181 gctgagattg ggcttaagtt gattgacttt aagctagagt tcggttttga caaggatggc
     9241 aagattatct tggcagatga attttcacca gataactgcc gtttgtggga tgcggatggc
     9301 aaccacatgg ataaggatgt tttccgtaga ggattgggag aactaacaga tgtttacgag
     9361 atcgtctggg aaaagttgca ggggttgaaa taatctgttt gcaacggaaa accttcgtct
     9421 ctcaactaaa aggactcagg ctgaaaaggt cccccagacc ttttcactcc gtaggggatt
     9481 aggagaacta acagacgttt acgaagttgt ctgggagaag ttgcaggaat tgaaataaca
     9541 gcctcaaggc tgtttaggaa tattgcaaga gctgaaaaaa aggaataagg attgatggat
     9601 aaacgtattt ttgttgaaaa aaaggctgat tttcaggtca agtcagagag tttggttaga
     9661 gaactccagc acaacttggg actttcaagt ttgaaaagta ttcgtattgt gcaagtgtat
     9721 gatgtatttg atttggctga ggacttgttt gcgcctgcag agaaacacat cttctctgag
     9781 caggtgacag accatgtttt ggacgaagcg gctgtgcagg cggatcttgc caactatgct
     9841 ttctttgcca ttgaaagcct accagggcag tttgaccagc gtgcagcatc ttcacaggaa
     9901 gccttgcttt tactaggaag ttcaagtgat gtaacggtta atacagccca actttacttg
     9961 gtgaatgaag atattgatgc gactgagttg gaagcggtca agaactatct gctcaaccca
    10021 gtggattctc gtttcaagga tatcacgaca gggattgcca agcaggaatt ttcagagtca
    10081 gacaagacca ttcctaaatt gactttcttt gaaagctata cagcggaaga ttttgcgcgc
    10141 tacaaggctg aacaagggat ggctatggaa gtggatgatt tgctctttat ccaagactac
    10201 tttaagtcaa tcgggcgcgt tccaactgag accgaactca aggttttgga tacttactgg
    10261 tctgaccact gccgtcacac gacttttgag acagagttga aacacatcga cttttcagct
    10321 tctaaattcc aaaagcaatt gcagtcaacc tatgacaagt atattgccat gcgtgatgag
    10381 ttggggcgta cggaaaaacc acaaaccttg atggatatgg ccactatttt cggtcgttat
    10441 gagcgtgcta atggacgttt ggacgacatg gaagtgtctg atgaaatcaa tgcttgctca
    10501 gtcgaaattg aagtggacgt tgatggtgtc aaggaaccat ggctccttat gttcaaaaat
    10561 gaaacccaca accatccaac agaaattgag ccatttggtg gggctgctac ctgtatcggt
    10621 ggggccattc gtgatccatt gtcaggtcgc tcatatgttt accaagccat gcgcatctca
    10681 ggtgctggag atattacagc accgatttcg gaaacgcgtg ctgggaaatt gccacaacaa
    10741 gtcatttcta agacagctgc tcatggttat tcttcttacg gaaaccagat tgggcttgca
    10801 acaacctacg ttcgtgaata cttccaccca ggctttgtag ctaaacgcat ggagcttggt
    10861 gctgttgtcg gagcggctcc taagggcaat gttgtccgtg aaaaaccgga agcgggtgat
    10921 gtcattatcc tccttggagg taagactgga cgtgatggtg tcggtggtgc gacgggctct
    10981 tctaaggttc aaacggttga gtctgtggaa actgctggag ctgaggttca aaaagggaat
    11041 gccatcgaag aacgtaagat tcagcgcctc ttccgtaatg gcaatgtcac tcgtcttatc
    11101 aagaaatcta atgactttgg tgctggtgga gtctgtgtgg ctatcggtga attagcagac
    11161 ggtctggaaa ttgaccttaa caaggtgcct cttaaatacc agggcttgaa tggcacagaa
    11221 attgctatct ctgaatctca agaacggatg gctgtggtgg ttcgtcctga ggatgtggat
    11281 gccttcgttg ctgaatgtaa caaagagaat attgatgctg ttgtggtggc gacagtgact
    11341 gaaaaaccaa atctagtcat gcactggaat ggtgaaacca tcgtggactt ggaacgtcgt
    11401 ttccttgata caaacggtgt gcgcgtagtc gttgatgcca aggttgtaga caaggatgct
    11461 aaacttccag aagaacgtca aacatctgct gacacacttg aagcagatac ccttacggtt
    11521 ttatctgacc tcaaccatgc gagtcaaaaa ggattacaga ctatctttga ctgttctgtt
    11581 ggacgctcta cggttaatca cccacttggc ggtcgctacc aactcacacc aactgaggct
    11641 tctgtgcaga agttgccagt tcaacacgga gtgactcaca ctgcgtctgt catagctcaa
    11701 ggattcaatc catatgtagc agaatggtct ccataccacg gtgctgccta tgcggtgatc
    11761 gaagcaactg ctcgattggt tgctacgggt gccaactggt ctaaggctcg cttctcttat
    11821 caagagtact tcgagcgcat ggacaaacaa gctgagcgtt ttggtcagcc agtggcagct
    11881 ctcctaggct ccatcgaagc tcagattcag cttggcttgc catctatcgg tggtaaggac
    11941 tctatgtctg gtacctttga agaattgacc gtaccaccaa ccttggttgc ttttggagtg
    12001 acaacagcag atagccgtaa ggtgctctct ccagaattta aagttgctgg ggaaaacatc
    12061 tactacatcc caggtcaagc tcttgctgca gagattgatt ttgccttaat taagaaaaac
    12121 tttgctcagt ttgaagccct tcaaaaggct taca
//
