LOCUS       c00031_NZ_JMKI..       10801 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JMKI01000031.1 Synergistes jonesii strain 78-1 contig_31, whole
            genome shotgun sequence.
ACCESSION   NZ_JMKI01000031
VERSION     NZ_JMKI01000031
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:11:19
            Original ID  :: NZ_JMKI01000031.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 67613
            Orig. end    :: 78414
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10801
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[72613:73414](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5801
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10801
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10801
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1353..1829)
                     /locus_tag="ctg31_65"
                     /transl_table=11
                     /translation="VTEGFDYALIDDLIGKHGRSSTAVIAVLQGIQEHYRYLPRWVFPY
                     ISKQLGVPQAHIYSVATFYENFSLTPKGKFVIKVCDGTACHVRGSIPILERLRRELALS
                     DSKVTTDDLSFTLETVSCLGACGLAPVLTVNDKVYPAMTPDKAARLVAALKEEF"
     PFAM_domain     complement(1365..1799)
                     /aSDomain="2Fe-2S_thioredx"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01257.21"
                     /description="Thioredoxin-like [2Fe-2S] ferredoxin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_65_0001"
                     /evalue="2.80E-47"
                     /label="ctg31_65"
                     /locus_tag="ctg31_65"
                     /protein_end="155"
                     /protein_start="10"
                     /score="160.3"
                     /tool="antismash"
                     /translation="DDLIGKHGRSSTAVIAVLQGIQEHYRYLPRWVFPYISKQLGVPQA
                     HIYSVATFYENFSLTPKGKFVIKVCDGTACHVRGSIPILERLRRELALSDSKVTTDDLS
                     FTLETVSCLGACGLAPVLTVNDKVYPAMTPDKAARLVAALK"
     CDS             complement(1936..2598)
                     /locus_tag="ctg31_66"
                     /transl_table=11
                     /translation="MTMDDAKPLSISRQSLQRMPIYLENLKKLRAAGKSHVSAAFLAGE
                     LGLHPVQVRKDLAAVSSVDGNPRIGFALAGLIEDMEDFLGCNNANEAVVVGVGNLGRAL
                     LSYKNFAGYGLSIIAGFDSDPAVAGTTVHGKEIFSASRITELCGRFGVHIGIITTPASS
                     AQEVCDAMLLGGIKAIWNFAPLHLNIPDDIIITNENLAASFAALSGRLRQQRDAPKL"
     PFAM_domain     complement(2047..2334)
                     /aSDomain="CoA_binding"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02629.21"
                     /description="CoA binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_66_0003"
                     /evalue="1.50E-16"
                     /label="ctg31_66"
                     /locus_tag="ctg31_66"
                     /protein_end="184"
                     /protein_start="88"
                     /score="61.0"
                     /tool="antismash"
                     /translation="ANEAVVVGVGNLGRALLSYKNFAGYGLSIIAGFDSDPAVAGTTVH
                     GKEIFSASRITELCGRFGVHIGIITTPASSAQEVCDAMLLGGIKAIWNFAP"
     PFAM_domain     complement(2428..2568)
                     /aSDomain="Put_DNA-bind_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06971.15"
                     /description="Putative DNA-binding protein N-terminus"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_66_0002"
                     /evalue="9.30E-14"
                     /label="ctg31_66"
                     /locus_tag="ctg31_66"
                     /protein_end="57"
                     /protein_start="10"
                     /score="51.3"
                     /tool="antismash"
                     /translation="ISRQSLQRMPIYLENLKKLRAAGKSHVSAAFLAGELGLHPVQVRK
                     DL"
     CDS             complement(2793..3503)
                     /locus_tag="ctg31_67"
                     /transl_table=11
                     /translation="MAIITLYKVSFSCEEVLAKEKEKRKGKKLPEAMENGAYAAFEEAL
                     RLVELKAIVETFPIRDISGESVEIARGSVGERFHVGPRVAGLLMPAKEIAAALCTAGGR
                     VADKIHQYGAEGENILMYYLDIFAVKALDELAAKVSAHVEEGAKERGWGVGPLMQPGSV
                     EGWAVTGQKTLFALCQGEQLGLSINESSMLVPHISDSLIIGVGPDYANKRVGSLCPECP
                     RYAVCLWRRENVAE"
     CDS             complement(3563..4192)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 84.4; E-value: 2.2e-25)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg31_68"
                     /transl_table=11
                     /translation="MVSKKSPRQIKAEKTKQTIFDYAIRLFQQYGYHSVSVDDIVEASK
                     TSVGTFYHYFKCKEELIIMFLSTYTNKYYEDYERGKLVQEKDKPAMDRLYDFLLFSLDI
                     SDAGGEEFQRIAMAYILRADSARPAYEYMLSPERAFARICKKLIAEGQEKGEIRRDRSV
                     EELFSTVALFSNGIDERWFMSRGSFDPRKEYGGVLWEFMRNMLTPR"
     PFAM_domain     complement(4007..4138)
                     /aSDomain="TetR_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00440.25"
                     /description="Bacterial regulatory proteins, tetR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_68_0004"
                     /evalue="5.10E-15"
                     /label="ctg31_68"
                     /locus_tag="ctg31_68"
                     /protein_end="62"
                     /protein_start="18"
                     /score="55.1"
                     /tool="antismash"
                     /translation="IFDYAIRLFQQYGYHSVSVDDIVEASKTSVGTFYHYFKCKEELI"
     CDS             4628..4975
                     /locus_tag="ctg31_69"
                     /transl_table=11
                     /translation="MEAYTEPYGLLGKQTVDAAQALKSLQEELEAINFYNQRAGTCTNE
                     DLKRIMAHNRDEEIEHAAMLIGWLKVYMDGWDKEIGDYVVNAQAGNMGVDGGEDVPEES
                     SGDQGLGIGKL"
     PFAM_domain     5001..5750
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_70_0005"
                     /evalue="8.00E-68"
                     /label="ctg31_70"
                     /locus_tag="ctg31_70"
                     /protein_end="250"
                     /protein_start="0"
                     /score="228.6"
                     /tool="antismash"
                     /translation="MDILKRSLAPVTGEAWAEIDAQAADVLRGVLTGRRVADVSDPKGW
                     RCDSVSSGTLSLAEGSPVEGVNYGIREVLPLVEVRVPFSLPMWDLDDISRGCRTTDFTP
                     LQAAARRAALFEDTAIFKGLEEAGILGIEAETDNSPVEAGLDDDSLIKAVYAATHVLSS
                     RNVGGPYALVCSKRVWEKIATSNAAYPLRKSLGKIVDKIIISRQYDADFVASLRGGDSE
                     LVIGQDFSVGYQSHSTTEVNFYITETFT"
     CDS             5001..5801
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg31_70"
                     /sec_met_domain="Linocin_M18 (E-value: 1.7e-68, bitscore:
                     224.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDILKRSLAPVTGEAWAEIDAQAADVLRGVLTGRRVADVSDPKGW
                     RCDSVSSGTLSLAEGSPVEGVNYGIREVLPLVEVRVPFSLPMWDLDDISRGCRTTDFTP
                     LQAAARRAALFEDTAIFKGLEEAGILGIEAETDNSPVEAGLDDDSLIKAVYAATHVLSS
                     RNVGGPYALVCSKRVWEKIATSNAAYPLRKSLGKIVDKIIISRQYDADFVASLRGGDSE
                     LVIGQDFSVGYQSHSTTEVNFYITETFTFRVVTPEAFVPLAISE"
     CDS             complement(5729..5869)
                     /locus_tag="ctg31_71"
                     /transl_table=11
                     /translation="MLAYGGARGEVESPRIIINYLVRYSLIASGTKASGVTTRKVKVSV
                     M"
     CDS             complement(6199..7287)
                     /NRPS_PKS="Domain: Aminotran_5 (59-323). E-value: 1.1e-20.
                     Score: 65.7. Matches aSDomain:
                     nrpspksdomains_ctg31_72_Aminotran_5.1"
                     /NRPS_PKS="type: other"
                     /locus_tag="ctg31_72"
                     /transl_table=11
                     /translation="MQTYKIPLVPGPVSVPQKYREAYLTDYGSSDVEDEFFALLSDNIS
                     LLRRVLKTKNDVAIGSGEAMSALWGAMKSLVGPGDKFLTISNGLFGHGFGEMAEALGAR
                     VEYLEAPDGEFVTAEQTRRKISEFGPDFISAVHCETPSGLLNPLAEIAPAVAESGAIFI
                     VDFVASALGADVRVDEWGIDIGLLGSQKCLSILPDIHATTVSERAWKRAARVNYAGYDA
                     LLPWKNVLKTKAMPYTHNWHANKAMNLSLKDSLEEGLENGFRRHEEAAALCRRRAKEMG
                     LSLYAKDEKLSSPTVTAIMIPDGWTWEELDAEFRKEGLAVGGSWGKLAGKVFRIGHMGS
                     QANAELVKRGMDVVEKVISKKL"
     aSDomain        complement(6319..7110)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg31_72_Aminotran_5.1"
                     /evalue="1.10E-20"
                     /label="ctg31_72_Aminotran_5.1"
                     /locus_tag="ctg31_72"
                     /protein_end="323"
                     /protein_start="59"
                     /score="65.7"
                     /tool="antismash"
                     /translation="GSGEAMSALWGAMKSLVGPGDKFLTISNGLFGHGFGEMAEALGAR
                     VEYLEAPDGEFVTAEQTRRKISEFGPDFISAVHCETPSGLLNPLAEIAPAVAESGAIFI
                     VDFVASALGADVRVDEWGIDIGLLGSQKCLSILPDIHATTVSERAWKRAARVNYAGYDA
                     LLPWKNVLKTKAMPYTHNWHANKAMNLSLKDSLEEGLENGFRRHEEAAALCRRRAKEMG
                     LSLYAKDEKLSSPTVTAIMIPDGWTWEELDAEFRKEGLAVGG"
     PFAM_domain     complement(6706..7110)
                     /aSDomain="Aminotran_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00266.21"
                     /description="Aminotransferase class-V"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_72_0006"
                     /evalue="5.30E-13"
                     /label="ctg31_72"
                     /locus_tag="ctg31_72"
                     /protein_end="194"
                     /protein_start="59"
                     /score="48.8"
                     /tool="antismash"
                     /translation="GSGEAMSALWGAMKSLVGPGDKFLTISNGLFGHGFGEMAEALGAR
                     VEYLEAPDGEFVTAEQTRRKISEFGPDFISAVHCETPSGLLNPLAEIAPAVAESGAIFI
                     VDFVASALGADVRVDEWGIDIGLLGSQKCLS"
     CDS             complement(7363..7833)
                     /locus_tag="ctg31_73"
                     /transl_table=11
                     /translation="LIMSDLAGKIQSDLVAAMKNKDELKLSVLRMLKAAMQLSQVEKGR
                     QKQLTDDDILTLVKRLIKQRSEAAEVYRKGGAEERAQRELEEAKVLEAYQPTQLSDEEI
                     MKAVERAAAEVHAAGMKDMGKMMGRTMAAVKGLADGNRVKAAVQKYLEQSAH"
     PFAM_domain     complement(7381..7809)
                     /aSDomain="YqeY"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF09424.12"
                     /description="Yqey-like protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_73_0007"
                     /evalue="1.90E-42"
                     /label="ctg31_73"
                     /locus_tag="ctg31_73"
                     /protein_end="151"
                     /protein_start="8"
                     /score="144.9"
                     /tool="antismash"
                     /translation="KIQSDLVAAMKNKDELKLSVLRMLKAAMQLSQVEKGRQKQLTDDD
                     ILTLVKRLIKQRSEAAEVYRKGGAEERAQRELEEAKVLEAYQPTQLSDEEIMKAVERAA
                     AEVHAAGMKDMGKMMGRTMAAVKGLADGNRVKAAVQKYL"
     CDS             complement(7830..8018)
                     /locus_tag="ctg31_74"
                     /transl_table=11
                     /translation="MTTVTRRDNESIEDALKRFKREIRKVGVLREAKRHEHYEKPSEIK
                     KRKKAEMARNRGRRGDY"
     aSDomain        complement(7845..8012)
                     /aSDomain="TIGR00030"
                     /aSTool="tigrfam"
                     /description="S21p: ribosomal protein bS21"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg31_74_0001"
                     /evalue="1.20E-18"
                     /identifier="TIGR00030"
                     /label="ctg31_74"
                     /locus_tag="ctg31_74"
                     /protein_end="58"
                     /protein_start="2"
                     /score="64.6"
                     /tool="antismash"
                     /translation="TVTRRDNESIEDALKRFKREIRKVGVLREAKRHEHYEKPSEIKKR
                     KKAEMARNRGR"
     PFAM_domain     complement(7854..8009)
                     /aSDomain="Ribosomal_S21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01165.22"
                     /description="Ribosomal protein S21"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_74_0008"
                     /evalue="3.20E-19"
                     /label="ctg31_74"
                     /locus_tag="ctg31_74"
                     /protein_end="55"
                     /protein_start="3"
                     /score="68.5"
                     /tool="antismash"
                     /translation="VTRRDNESIEDALKRFKREIRKVGVLREAKRHEHYEKPSEIKKRK
                     KAEMARN"
     CDS             complement(8177..9499)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 54.3; E-value: 1.6e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg31_75"
                     /sec_met_domain="PF04055 (E-value: 1.7e-24, bitscore: 80.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGILKGKKFSIYVQGCRTNQYEGEAIAAALEAAGALRRGDAPDII
                     VIVSCTVTATADRKCRKIIRRARRENPCAVIALCGCYAQKLSEEERALLDVDIALGNRL
                     KHKLPRLIAARLAGGAPTVEANADVGRDGSWDALSLDRPRLHTRAFLKVQEGCSHCCSY
                     CIVPSVRGRPVSRPMEEAVEEARRVTDGGCPEIVLTGVHLGLYEDLPLLVRRIGALPNI
                     KRLRFGSIEPFAVDEKLLAALVECPAFCRHLHMPLQSGDDGVLSAMRRGYKAADFAKTA
                     ECARAMLGDELHVSTDLMVGFPSEDESAFRRSMEFVRGQEFGKVHVFPYSPREGTDAAA
                     MPQLEESEVRPRVAEALALASELHKKFCSRWIGRELAILVEETDGAAAKGLSGNYIRVT
                     AKAAAAVNETISVVPSRYAGEGLTTEGVSASSSLCSDISVI"
     aSDomain        complement(8270..9478)
                     /aSDomain="TIGR00089"
                     /aSTool="tigrfam"
                     /description="TIGR00089: radical SAM methylthiotransferase,
                     MiaB/RimO family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg31_75_0002"
                     /evalue="7.90E-93"
                     /identifier="TIGR00089"
                     /label="ctg31_75"
                     /locus_tag="ctg31_75"
                     /protein_end="410"
                     /protein_start="7"
                     /score="309.5"
                     /tool="antismash"
                     /translation="KFSIYVQGCRTNQYEGEAIAAALEAAGALRRGDAPDIIVIVSCTV
                     TATADRKCRKIIRRARRENPCAVIALCGCYAQKLSEEERALLDVDIALGNRLKHKLPRL
                     IAARLAGGAPTVEANADVGRDGSWDALSLDRPRLHTRAFLKVQEGCSHCCSYCIVPSVR
                     GRPVSRPMEEAVEEARRVTDGGCPEIVLTGVHLGLYEDLPLLVRRIGALPNIKRLRFGS
                     IEPFAVDEKLLAALVECPAFCRHLHMPLQSGDDGVLSAMRRGYKAADFAKTAECARAML
                     GDELHVSTDLMVGFPSEDESAFRRSMEFVRGQEFGKVHVFPYSPREGTDAAAMPQLEES
                     EVRPRVAEALALASELHKKFCSRWIGRELAILVEETDGAAAKGLSGNYIRVTAKAAAAV
                     NETI"
     PFAM_domain     complement(8549..9043)
                     /aSDomain="Radical_SAM"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04055.23"
                     /description="Radical SAM superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_75_0010"
                     /evalue="4.10E-22"
                     /label="ctg31_75"
                     /locus_tag="ctg31_75"
                     /protein_end="317"
                     /protein_start="152"
                     /score="79.4"
                     /tool="antismash"
                     /translation="VQEGCSHCCSYCIVPSVRGRPVSRPMEEAVEEARRVTDGGCPEIV
                     LTGVHLGLYEDLPLLVRRIGALPNIKRLRFGSIEPFAVDEKLLAALVECPAFCRHLHMP
                     LQSGDDGVLSAMRRGYKAADFAKTAECARAMLGDELHVSTDLMVGFPSEDESAFRRSME
                     FV"
     PFAM_domain     complement(9200..9475)
                     /aSDomain="UPF0004"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00919.22"
                     /description="Uncharacterized protein family UPF0004"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg31_75_0009"
                     /evalue="1.50E-15"
                     /label="ctg31_75"
                     /locus_tag="ctg31_75"
                     /protein_end="100"
                     /protein_start="8"
                     /score="57.1"
                     /tool="antismash"
                     /translation="FSIYVQGCRTNQYEGEAIAAALEAAGALRRGDAPDIIVIVSCTVT
                     ATADRKCRKIIRRARRENPCAVIALCGCYAQKLSEEERALLDVDIAL"
ORIGIN
        1 tcgcgccggc ggccgcgagc gaatcaaagt ccagcggcag gtcgaggtct cccgcagtga
       61 ggcagccgcc ggaagggccg cctatctgca cggctttgaa gtccgcgccg ccgcgcatgc
      121 cgccgccgac ctcaaagacg acatcccgca gcgtagtgcc catagggacc tctatgagcc
      181 cggtgttctc tatatttccc gtgagggcga aggccttcgt gccggggctc ttctccggcc
      241 cgagcgacct gaaccaggcg acccctctct cgattatgag cggtacgtta gcgaaggttt
      301 cgacgttgtt gagcactgtg gggctgtcaa aaaggccgtg ttcgactgtg cgcggcggct
      361 tgacgcgcgg catgccgcgc ctgccttcta tcgaggcggt tagggcgctg ccctcgccgc
      421 agacgaacgc tcccgcgccg cggttgatat gcagatggaa agaaaagccg ctgccgagga
      481 tgtcgtcgcc gagcagccct atttcctcgg cctgcgctat cgcggcgcgc agccgcgaga
      541 ccgctatagg gtattcggcg cggacgtata catagccgtt ccgcgcaccg caggcgatgc
      601 ccgcgatcat catgccttca agcatgcggt gcgggtcgcc ctccatgata cttctatcca
      661 tgaacgcgcc cgggtcgccc tcgtctccgt tgcagacaat gtacttctgc gccgcttttt
      721 ggcgcttcac ctggctccac ttgcgcccgg tcggaaagcc gccgccgccg cggccgcgca
      781 gccccgattg ctctatcatc tcgacgatct cttccgccgt catctcaaaa agcgcgcgct
      841 ccagagcctg atagccgccg atcgcaagat attcatttat cgaggttgcg tcgatgtgcc
      901 cgcaatgttc gaggacgcgg cgtgtctgct tcctatagaa ggggatatcg tcctgcctgc
      961 tgaagctttg tccttccttc gtataggcta agcgcgcgat cggttcgccg ccgattatcg
     1021 tcttctccac gatctcctcg cagtcttcca cgccgacctt gacgtagagc cacccctggg
     1081 ggtcgatgcg tacgagcggc cccatctcgc agaaaccgtg gcagccggat tttttaaggc
     1141 cgacggagcg tccgtgcggc tcctcgcgga gttcgaccgc gacgttgagg ccgcgcgcct
     1201 ccattatctt tttcaattcg tcgtatatct ccagcgatcc gcttgagata cagcctgtcc
     1261 cggcgcagac gagtatcctc tttttctccc ccgcaaggct tgccgcgcac atccggcgca
     1321 gctcacgaag ttcttcgcgg tttcccgtca tcttaaaatt cctccttaag cgccgcgact
     1381 agtctcgcgg ctttgtcggg ggtcatcgca gggtaaacct tgtcgttgac cgtgagcacc
     1441 ggcgcgaggc cacaggctcc gagacatgac accgtctcca gggtgaagct gagatcgtcg
     1501 gtcgtcacct tactgtccga gagcgcgagc tcccggcgca gccgctcgag tatggggata
     1561 gacccgcgca cgtggcaggc cgtgccgtcg catactttta ttacgaactt acccttagga
     1621 gtgagagaaa agttttcata aaaggtggcg acgctgtaga tgtgtgcttg cgggactccc
     1681 agctgtttcg aaatgtaggg gaaaacccac cttggcaggt aacggtaatg ttcctgaata
     1741 ccctgcaaca ccgcgatgac ggccgtgctc gaccttccgt gtttgccaat taaatcgtcg
     1801 attagagcgt agtcgaaacc ttctgtcaca atgcatccct cttctttttt atatgccatt
     1861 tttcagacaa agcaaaatcg ttatccctgc aaatgtagcg ggcccctgga ttgccccttc
     1921 ccgacgtttc ggctgctaaa gcttcggagc gtctctctgc tgccgcagcc ttccggagag
     1981 cgctgcaaaa gaagcggcaa ggttttcgtt cgttattatt atgtcgtccg gtatgttgag
     2041 gtgtagcggc gcgaagttcc aaatagcctt gatgccgcct aaaagcatcg catcgcacac
     2101 ttcctgtgca gacgacgccg gcgtcgtgat tatcccgatg tggacgccga atcgtccgca
     2161 aagctcggtg atccgtgaag cgctgaaaat ctccttgccg tgcaccgtgg tgcccgcgac
     2221 ggcggggtcg ctgtcaaatc ccgctatgat ggacaagccg tagccggcga aatttttgta
     2281 agagagcagg gcgcgtccga ggttgccaac gccgaccacc acagcctcat tagcattgtt
     2341 gcagccgagg aaatcctcca tatcctctat aaggcccgca agcgcgaagc cgatgcgcgg
     2401 gttcccgtcg acgctggaga cggcggcgag gtcttttctt acctgcacgg gatggagccc
     2461 cagctctcct gcgaggaagg ctgcggagac atggctcttc cccgcggcgc ggagtttttt
     2521 gagattctca agataaatgg gcatgcgctg aagagactgc ctcgatatgc tgagcggttt
     2581 cgcatcgtcc atcgtcatca aattaccccc tttgcagaaa taaatattct attatcgata
     2641 atgatatatc gatattaata ttttgcaacc cctgttttag aaaatatttt attcaacata
     2701 ttatcaagat tgatttgtgt cacaacaacg agagaagggg cccggcatcg ccgggcccct
     2761 tctctcgttt tattcgtctg cgcggatacg ctttactccg cgacgttttc ccttctccac
     2821 aggcagacgg cgtagcgcgg acattcgggg cagagcgagc cgaccctctt atttgcgtaa
     2881 tccggtccta cgccgataat aagagaatcg gaaatgtgcg ggacgagcat cgaggactcg
     2941 ttgatcgaaa gcccgagctg ctcgccttgg cagagggcga agagagtctt ttgtccggtc
     3001 acagcccatc cctctaccga gccgggctgc atcagcgggc cgacgcccca gcccctctcc
     3061 ttcgcgccct cttcgacatg cgcgcttacc ttcgcggcga gctcgtcaag cgccttgacc
     3121 gcgaaaatgt cgaggtaata catcaaaatg ttttcgcctt cggcgccgta ttgatgaatt
     3181 ttatcggcga cccttccgcc ggccgtgcag agggcggccg ctatctcctt agcaggcatg
     3241 aggagcccgg caacgcgggg gccgacgtgg aacctttcgc ctacgcttcc ccttgcgatt
     3301 tccacagact ctcccgatat gtcccttata ggaaaagttt cgacgatggc cttcaattcg
     3361 accagacgca gcgcttcttc gaaagccgcg tacgcgccat tttccatggc ttcgggaagc
     3421 tttttccctt tgcgtttttc tttttccttc gccagaacct cttcgcagct gaagctgact
     3481 ttgtagagag tgatgattgc catgttgccg cccccttcgt ttttatttta attacccgcc
     3541 gcagaatttt tatttgctaa aactatctcg gcgtcagcat gttgcgcatg aattcccaca
     3601 ggaccccgcc gtactccttc cgcggatcga aggagccgcg gctcatgaac catctttcgt
     3661 ctatgccgtt tgagaagagc gcgaccgtag agaagagctc ctctacgctc ctgtcgcggc
     3721 ggatctcgcc cttctcctgc ccctccgcta taagtttttt gcagatgcgc gcgaaggccc
     3781 tctctggcga aagcatatac tcataagcgg gacgggcgct gtcggccctc agaatatagg
     3841 ccatcgcgat gcgctggaat tcttcgcctc cggcgtcgga tatgtcgagc gaaaagagaa
     3901 ggaagtcgta aaggcggtcc atcgccggtt tgtctttttc ttgaacgagc ttgccccgtt
     3961 cataatcttc gtaatattta ttggtgtaag tgctgaggaa cattattatc agctcctcct
     4021 tgcacttgaa ataatgataa aaggttccga ccgacgtttt tgaagcctcg actatatcgt
     4081 cgaccgaaac gctgtggtag ccgtactgct gaaacagcct tatggcgtag tcgaatatcg
     4141 tttgtttggt tttctccgcc ttgatctgcc tcgggctctt ttttgatacc ataatcccat
     4201 ctccttatat ggcgcctgcg ctgcggccag cttaagccgc aaaataaata taaccgtttt
     4261 ttgtcagcat actaatagaa cagcctctgt gattataata ttgtttcatc gcctccgtaa
     4321 atatacagtc taaatttaaa tggcttaaat aaatcgaaac atttcgctct ataacgcgcg
     4381 gctcgctttc atatcgcgga gcgggggcgg cggcgccgag tttacgctgc gctttctttc
     4441 aaatcggcgg taatttttgc gttaattacg cttgcaagtt gccaaccctg atggtaaaat
     4501 ctaaaatggt ttcaaataaa aacagcaggc gcctatactc tcatccgacg gaacaagagg
     4561 acgggaggcc cggcgcggca gctaaaacgc ctgttcaagg caaaaaaatc gcagggggga
     4621 tatctatatg gaagcataca cggagcctta cggcctgctc ggcaagcaga ccgtcgacgc
     4681 ggcccaggcg ctcaaaagcc tgcaggagga gctggaggcg atcaattttt acaaccagcg
     4741 cgccggcacc tgcacgaacg aagatctcaa gcgcattatg gcgcacaacc gcgacgagga
     4801 gatagagcac gctgcgatgc tcatcggctg gctgaaggtc tatatggacg gctgggacaa
     4861 agagatcggc gactatgtcg tcaacgctca ggcggggaat atgggcgtcg acggcggaga
     4921 ggacgtcccc gaagagagct ccggcgatca ggggctcggc ataggaaagc tgtaatacat
     4981 aaagcgaagg gagaatgaac atggatatac tcaaaagatc attggcgccc gtcacaggcg
     5041 aggcttgggc ggagatagac gctcaggcgg cggacgtgct tcgcggcgtg cttacggggc
     5101 gccgggtggc ggacgtatcc gaccccaagg gatggcgctg cgactctgtt tcctcgggaa
     5161 cgctttctct cgcggaaggc tcgccggtcg aaggcgtaaa ctacggtata cgcgaagtgc
     5221 tgccgctcgt ggaagttcgc gtccccttct ctctgccgat gtgggatctt gacgacatct
     5281 cgcgcggatg caggacgact gacttcacgc cgctgcaggc ggcggcgcgc cgggcggccc
     5341 tctttgaaga caccgcgata ttcaaggggc ttgaagaggc cgggatcctc ggtatagagg
     5401 cggaaaccga caacagtccc gtcgaagcgg ggcttgacga cgattcgctc atcaaagccg
     5461 tctacgcggc gacgcatgta ctctcgtcgc gcaacgtcgg tggcccatac gcgcttgtct
     5521 gctcaaaaag agtctgggag aaaatcgcta cctccaacgc cgcctacccg ctgcgcaaga
     5581 gcctggggaa gatcgtcgac aagatcataa tttccaggca gtacgacgcc gacttcgtcg
     5641 cctcgctgcg cggcggcgac agcgagctcg tgatcggcca ggatttttcc gtcggctacc
     5701 agtcgcattc gactacggag gtaaacttct acatcaccga gactttcacc ttccgcgtcg
     5761 tcacgcccga ggctttcgtg ccgctcgcaa taagcgaata acgcacaaga taattgataa
     5821 ttatgcgggg agattccacc tcccctcttg cgccgccgta tgccagcatg gatacggcga
     5881 ccctgtttac atcccaaacc gtgaaattta agcggggccc catatgtgcg tatggaagcc
     5941 cctgtgcatg gaggtaagta aggtctcgga gcgcgccgat gtgtggggtc ggcgcgttcc
     6001 gcctgtgaag agatcgccgc gtttgcgagg tcagcggatt cctatccggt tttcaaaagc
     6061 cggaggcaga gcttttccgc cgccttaagc cattcaggcg cttttaattt ttatctcgcc
     6121 cggctgatgc gctccgggga tgcatatctc cacaagcgtc cccctttaag gtatttcagt
     6181 gaccgctaac tagagaagct ataatttttt gcttataact ttttctacga cgtccatgcc
     6241 gcgcttcacg agttcggcgt ttgcctggct gcccatgtgt ccgatgcgga agacttttcc
     6301 cgcgagcttt ccccagcttc ccccgacagc gagcccctct ttgcggaact cggcgtcgag
     6361 ctcctcccac gtccaaccgt ctggaatcat tatcgccgtt accgtcggcg acgagagctt
     6421 ttcatccttc gcgtagagcg aaagccccat ctccttcgcg cggcggcggc agagcgccgc
     6481 ggcttcctcg tggcgcctga atccattttc cagcccctct tcgagcgaat ctttgagaga
     6541 gaggttcatg gccttgttgg catgccagtt gtgcgtgtag ggcatcgctt tggttttgag
     6601 gacgtttttc cacggcagga gcgcgtcgta gcccgcgtag tttaccctgg ccgcccgttt
     6661 ccacgcgcgt tcgcttaccg tggtcgcgtg gatgtccggc aggatcgaga ggcatttctg
     6721 actgcccagg agtcctatgt ctatccccca ttcgtcgacg cggacgtccg cgccgagcgc
     6781 gctcgcgacg aagtcgacta tgaatatcgc tccgctttcg gcgacggccg gcgctatttc
     6841 ggcgagaggg ttgagcagtc ccgacggcgt ctcgcagtgg accgcggata tgaagtccgg
     6901 cccgaattcg gaaatttttc tgcgcgtctg ttccgccgtt acgaattcgc cgtccggcgc
     6961 ttcgaggtat tcgacgcggg ctccgagcgc ttccgccatt tcgccgaagc cgtgcccgaa
     7021 gaggccgttc gagatcgtca ggaatttgtc gccgggcccg acgaggctct tcatggcgcc
     7081 ccacagcgcc gacatcgcct cgccggagcc tatcgcgacg tcgtttttcg ttttgagcac
     7141 gcgccgcagc agcgagatgt tatcggaaag cagagcgaag aattcgtctt cgacgtcgct
     7201 gctcccgtag tccgtcagat atgcttcgcg gtatttctgc gggaccgata ccggccccgg
     7261 gacgagtgga attttgtatg tctgcattta tttgcctcct tgcgcgaaaa acgccggaga
     7321 agcgttgacc tccggcgttt cttgttgctt tctgctttga gtctaatgcg ccgactgttc
     7381 cagatacttc tggaccgcgg ccttgactct gtttccgtcg gctaggcctt ttactgccgc
     7441 catcgttctg cccatcattt ttcccatgtc tttcatgccc gcggcatgca cttccgcggc
     7501 cgctctctcg accgccttca ttatttcttc gtcggaaagc tgcgtgggct gatatgcctc
     7561 gagcaccttg gcttcttcga gctccctctg cgcccgctcc tctgcgccgc ccttcctgta
     7621 tacttcggcg gcttcgctcc tttgcttgat gagccttttg acgagcgtca ggatgtcgtc
     7681 gtcggtcagc tgcttttgcc tgcccttctc cacctgcgat agctgcatcg cggctttgag
     7741 catacggagg acggagagct tgagctcatc tttatttttc atggcggcga cgagatcgct
     7801 ttggattttg cctgcaagat cggacatgat caataatcgc ccctcctgcc tctgttacgt
     7861 gccatctcgg ccttcttacg cttcttgatt tcgctgggtt tttcgtaatg ttcatgcctc
     7921 ttggcctcac gaagcacacc aaccttacga atctctctct tgaaacgttt aagggcgtct
     7981 tcgatcgact cattgtcgcg tctggttacg gtggtcatca acattccccc ctttcaaccg
     8041 gggataacac ctaagcgaaa atttcttcac acttttggaa tatgcactcc gcctgatgtc
     8101 attcgatata ttactatcat tgtattatgg gggataggaa gccgttttgt caataacggt
     8161 aaacgcgaca attcaatcaa atcactgaaa tatctgagca aagcgatgaa ctcgcggaga
     8221 cgccctcagt cgtgagccct tcgccggcgt atctcgacgg gacgactgaa atcgtttcgt
     8281 ttaccgctgc cgccgccttc gccgttacgc ggatgtagtt gccgctcagt cccttggccg
     8341 cggcgccgtc cgtttcctca acgagtatcg caagctccct gcctatccag cgcgagcaga
     8401 attttttatg cagctccgag gcgagcgcga gcgcctcggc gacgcgcgga cggacttccg
     8461 attcttcaag ctggggcatc gcggccgcgt cggtgccttc gcgcggcgag tatgggaata
     8521 cgtggacctt gccgaactcc tgtccgcgca cgaattccat gctgcggcgg aacgcgcttt
     8581 catcctccga tgggaagccg accatcaggt ccgtgctgac gtgcagttcg tcgccgagca
     8641 tcgcgcgcgc acactcggcg gtctttgcga agtcggcggc cttatagccg cgccgcatcg
     8701 ccgaaagcac accgtcgtcc cccgactgca gcggcatgtg cagatgcctg cagaatgccg
     8761 gacattcgac gagcgcggcg agtagctttt cgtccaccgc gaagggctcg atggatccga
     8821 agcggaggcg ctttatgttc ggcagagcgc cgatgcgccg cacgagcagc gggaggtcct
     8881 cgtagaggcc gaggtgcacg ccggtcagca cgatctccgg gcagccgccg tcggtgacgc
     8941 gccgcgcctc ttctacggcc tcctccatcg ggcgcgagac gggcctgccg cgcaccgacg
     9001 gcacgatgca gtaggagcag cagtgactgc agccctcctg cacctttaga aaagcccgcg
     9061 tgtggaggcg cggcctgtcg agcgacagcg cgtcccacga gccgtccctt ccgacgtccg
     9121 cgttggcctc taccgtcggc gcgccgccgg cgagccttgc cgctatcagg cgcggcagct
     9181 tgtgtttgag cctgttcccg agcgctatgt cgacatcaag cagcgcgcgc tcctcttcgg
     9241 agagcttttg cgcgtagcat ccgcacaagg ctatgacggc gcacggattt tcgcgtctcg
     9301 cgcggcggat gatttttctg catttgcggt cggccgtcgc ggtgacggtg cagctgacta
     9361 tcacgattat gtcgggcgcg tcgccgcggc gaagcgcgcc cgccgcttcg agcgcggcgg
     9421 ctatcgcttc gccttcgtat tggttggtgc ggcatccctg aacgtatatc gaaaattttt
     9481 tgccctttaa tattcccatt tatcggctgc gcgggggcga agcgccccgc gcagcttaaa
     9541 ctccgtttcg ttagatgttt ctgaccttcg cgagcccggc gaagagctct ttcatcggtc
     9601 ccgcaagaag gcgctggcgc tcggcgaaaa ctttgccgta tatttcagcg ctcttagcgt
     9661 ccggctcgaa gcgcgctcgg aaggttaccc accgccgcat cgtctctttg atgtccttta
     9721 tgtcgccgac ggcgtgcgcc gcgacggcga cgtcggccat aagcccgccc tcgctcctcg
     9781 tcggtatgtt gtaagcgcca cctaagatgt cggcctttat ctgcgtccac agcgggctct
     9841 tgctgccgcc ttcggtgccg attatctcgt tcagcgggat cccgcattcg cggtaaattt
     9901 ttatcatctg agcgtattcg aaggctatcg cttcgagtat cgagcgccac atcgcggccc
     9961 tgtcgctgac gccgaaaagc ccggcgaaga cgccgcaggc gcccggcatg tcgggacctg
    10021 cgccctgcag gtacggatag aagagcagtc cgcgcgagcc ggccggaacg tcccccgcga
    10081 gcgtgtccat ctccgcgtaa aacatcgggt ctccggcgcg gttcgcgacg ttgtcgcgga
    10141 accagcgcag cgaaagcccg cccgcgcgta tcatgctcca atagaaataa gcgtcccgca
    10201 gcgtgcccat cgcgaacatc atcccgggag ccgcggttat cctgctgtcc gcctctttga
    10261 cggcgaccgc gaatatcgac gcggtgccgg cgacatccgt agcgaggcca ggttcgagaa
    10321 gccccgaggc gagcgccgac tgcatcgtgt cgccggcgcc agcggcgatc gggatgcccg
    10381 gcggaagtcc catcttctcg gcctcggctt tgcagagata tccgaccaca tcccacggct
    10441 ttactacgcg cggcagcatc tccatcggga tgccgagcgc ttctatctgt ttgtgcgacc
    10501 agtcgcgctt cttggcgtcg tagcctatca gccagccgga catcgttgcc cagtcgagga
    10561 aggcgtcctt cgcggagagc cccgcgagcg tgccgagcac gaatgggccg ttgttgacca
    10621 ccttgaccgc gctttcgcgg aaacctttat attcgttgag gaaccagcgg agtatcatcg
    10681 gcggcataaa ttcgtctacg atggcgttgc cgctctcttc ggtccatacg ggctctacgt
    10741 tttcgcgcac ccacgcggct tccccgcttg cgcggttgtc taggtagggg acgaagggcg
    10801 t
//
