LOCUS       NZ_OX460976.1          12954 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_OX460976.1 Carnobacterium maltaromaticum strain SF2022 isolate
            SF2022 chromosome SF2022_c1.
ACCESSION   NZ_OX460976
VERSION     NZ_OX460976.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:53:32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2441855
            Orig. end    :: 2454809
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..747)
                     /NRPS_PKS="Domain: PKS_KR (6-167). E-value: 1.4e-16. Score:
                     52.7. Matches aSDomain: nrpspksdomains_ctg1_2240_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     190.5; E-value: 5.8e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2240"
                     /sec_met_domain="adh_short (E-value: 1.8e-36, bitscore:
                     123.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.2e-07,
                     bitscore: 27.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIKDKVIIITGASSGIGEATAILLAQKGAKLVLAARREEKLQTI
                     VEKIKENSGEAVYFVTDVTKRIDNQKLVDFTIKTYGKVDVIFLNAGIMPNSPLSALKED
                     EWDQMIDINIKGVLNGLAAVLPYFVEQKSGHVLTTSSVAGLKAYPGGAVYGATKWAIRD
                     LMEVLRMESAQEGTNIRTATIYPAAINTELLDKITDSKTAEGMTSLYDKYGIAPERVAS
                     IVAYAIDQPEDVNINEFTVGPTSQPW"
     protocluster    1..12954
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[2446091:2450925]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4237..9070
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12954
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12954
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     PFAM_domain     complement(151..732)
                     /aSDomain="adh_short"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00106.27"
                     /description="short chain dehydrogenase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2240_0099"
                     /evalue="3.50E-58"
                     /label="ctg1_2240"
                     /locus_tag="ctg1_2240"
                     /protein_end="199"
                     /protein_start="5"
                     /score="196.4"
                     /tool="antismash"
                     /translation="KVIIITGASSGIGEATAILLAQKGAKLVLAARREEKLQTIVEKIK
                     ENSGEAVYFVTDVTKRIDNQKLVDFTIKTYGKVDVIFLNAGIMPNSPLSALKEDEWDQM
                     IDINIKGVLNGLAAVLPYFVEQKSGHVLTTSSVAGLKAYPGGAVYGATKWAIRDLMEVL
                     RMESAQEGTNIRTATIYPAAINTELLDKITD"
     aSDomain        complement(247..729)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2240_PKS_KR.1"
                     /evalue="1.40E-16"
                     /label="ctg1_2240_PKS_KR.1"
                     /locus_tag="ctg1_2240"
                     /protein_end="167"
                     /protein_start="6"
                     /score="52.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIIITGASSGIGEATAILLAQKGAKLVLAARREEKLQTIVEKIKE
                     NSGEAVYFVTDVTKRIDNQKLVDFTIKTYGKVDVIFLNAGIMPNSPLSALKEDEWDQMI
                     DINIKGVLNGLAAVLPYFVEQKSGHVLTTSSVAGLKAYPGGAVYGATKWAIRDLMEV"
     CDS_motif       complement(634..726)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_2240_0001"
                     /evalue="2.70E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_2240"
                     /protein_end="38"
                     /protein_start="7"
                     /score="20.0"
                     /tool="antismash"
                     /translation="IIITGASSGIGEATAILLAQKGAKLVLAARR"
     CDS             complement(770..1108)
                     /locus_tag="ctg1_2241"
                     /transl_table=11
                     /translation="MNIIIGKQLFQIELVSNQATKELIVRLPINLKMNDLHGNEKYAYF
                     SEILPTQEEKVDEIKKGDIMLYGSDCLVLFYKTFSTNYLYTKIGKVKEVDQLDFISEIE
                     TINVILVK"
     PFAM_domain     complement(803..1102)
                     /aSDomain="Cyclophil_like2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF18050.3"
                     /description="Cyclophilin-like family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2241_0100"
                     /evalue="1.30E-30"
                     /label="ctg1_2241"
                     /locus_tag="ctg1_2241"
                     /protein_end="102"
                     /protein_start="2"
                     /score="105.9"
                     /tool="antismash"
                     /translation="IIIGKQLFQIELVSNQATKELIVRLPINLKMNDLHGNEKYAYFSE
                     ILPTQEEKVDEIKKGDIMLYGSDCLVLFYKTFSTNYLYTKIGKVKEVDQLDFISE"
     CDS             complement(1139..1708)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 98.6;
                     E-value: 6.4e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2242"
                     /transl_table=11
                     /translation="MSNISLLQKIIGKEIVKDSPLFEEIHSVKKNNERLLMMLNADYYP
                     NEEVLKHLEKITSQKIDSSVKISQPFYSDFGKHIRFGKDIFINQNVTFVDLGGITFEDQ
                     VLIGPGSRLITVNHLISPKKRRGIKVEPIYIKKNAWLGANVTVLPGVTIGKNSIVAADS
                     TVTKDVPDNVIVVGSPAKVVREIEEE"
     PFAM_domain     complement(1208..1312)
                     /aSDomain="Hexapep_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14602.8"
                     /description="Hexapeptide repeat of succinyl-transferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2242_0101"
                     /evalue="5.00E-06"
                     /label="ctg1_2242"
                     /locus_tag="ctg1_2242"
                     /protein_end="167"
                     /protein_start="132"
                     /score="26.2"
                     /tool="antismash"
                     /translation="IYIKKNAWLGANVTVLPGVTIGKNSIVAADSTVTK"
     CDS             1835..2701
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 151.3; E-value: 5.5e-46)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2243"
                     /transl_table=11
                     /translation="MELRVLTYFLTVAREKTISKAAEVLHLSQPTLSKQLKELEEELSV
                     TLFIRGNRFITLTEDGIYLMNRGKEILSLVESTTTNLIKNEVISGELTIGGGESQAFDF
                     LSRILHGLRNDYPEINIHLYSGNADDVLEKIDKGLLDFGLVIDPVEKQKYEYIRLPLVD
                     SWGILVNNSHPIAYKKTVTPKDIQQTPLLISNQSFVDNQLSEWFGGNIEHLNVIGTYNL
                     LYNASLLVKEGVASVLCIDGIVNTANTNLTFVPFSPPLTANINIVWKKGQIFSSASKEF
                     LRLLKLV"
     PFAM_domain     1841..2017
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2243_0102"
                     /evalue="1.20E-19"
                     /label="ctg1_2243"
                     /locus_tag="ctg1_2243"
                     /protein_end="61"
                     /protein_start="2"
                     /score="70.0"
                     /tool="antismash"
                     /translation="LRVLTYFLTVAREKTISKAAEVLHLSQPTLSKQLKELEEELSVTL
                     FIRGNRFITLTEDG"
     PFAM_domain     2096..2692
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2243_0103"
                     /evalue="8.90E-24"
                     /label="ctg1_2243"
                     /locus_tag="ctg1_2243"
                     /protein_end="286"
                     /protein_start="87"
                     /score="84.1"
                     /tool="antismash"
                     /translation="ISGELTIGGGESQAFDFLSRILHGLRNDYPEINIHLYSGNADDVL
                     EKIDKGLLDFGLVIDPVEKQKYEYIRLPLVDSWGILVNNSHPIAYKKTVTPKDIQQTPL
                     LISNQSFVDNQLSEWFGGNIEHLNVIGTYNLLYNASLLVKEGVASVLCIDGIVNTANTN
                     LTFVPFSPPLTANINIVWKKGQIFSSASKEFLRLLK"
     CDS             complement(3239..4219)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 57.9; E-value:
                     1.4e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_2244"
                     /transl_table=11
                     /translation="MHNNNWRDHSSVYSQQHQKFYRWVLYPVILFLFLVSLFLAFAKKE
                     VVVRVPAQLTATKIDKLQVPLEANIKVNNLKENKEVKKGEVLVMFDTSVLQNEKEQFEQ
                     ENTSLEDQKKAAQLFIESIAKEQNLFEDEDEFGYSNQLKSLLLEKETQNTEQVLATTKQ
                     KIAVLIETKKKNNYTLQNITEQLVRGTLKSPSTGIVHLNEEVTGQIDVSKGTVLAEIYP
                     KQKESQLMFTALLPADEVTRIKVGMDVHFKLDKKGVASQTIEGTLKEISETSMTTEQGT
                     FYTIKGTLQSSKYFNNRYGMTGEVSLIIGKKSYWQQIKDVLLNQE"
     PFAM_domain     complement(3371..3652)
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2244_0104"
                     /evalue="1.80E-12"
                     /label="ctg1_2244"
                     /locus_tag="ctg1_2244"
                     /protein_end="283"
                     /protein_start="189"
                     /score="48.0"
                     /tool="antismash"
                     /translation="TLKSPSTGIVHLNEEVTGQIDVSKGTVLAEIYPKQKESQLMFTAL
                     LPADEVTRIKVGMDVHFKLDKKGVASQTIEGTLKEISETSMTTEQGTFY"
     CDS             complement(4237..6387)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 287.4; E-value:
                     3.8e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2245"
                     /sec_met_domain="TIGR01193 (E-value: 1.6e-251, bitscore:
                     834.2, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.1e-45, bitscore:
                     150.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQFTHIQQQDEKDCGVACIAMILKHYKTEIPIHKLRDFSGTDLE
                     GTSAFGLKKTFEKLFFDCPAIQADNDVWKEKELPLPLIAHILIDNSYMHYVVVYKINGE
                     TLSIDDPARGKIKKTVEEFAKEWTGILLLPTPKDSYVPSKEKVARISSFLPVIWLQKGF
                     VFHIIVASIFITLFGIGSSYYFQGILDYFIPNHARSTLNIVSVGLIVVYLFRVMFEYSR
                     NYLLVILGQRMSMVVMLQYFKHILSLPMNFFATRKSGEIISRFLDANKIIDALASATLS
                     VFLDIGMVLIVGITLAVQNGILFLITLASLPFYLVSILAFVKSYEKANQEEMVAGATLN
                     SSIIESLKGIETIKAYSGEEKVYHQVDREFVQLMKKSFRTATLDNVQQGIKHAIQLISS
                     ALILWLGSYYVMEGSISLGQLITYNALLVFFTDPLQNIINLQVKMQTAQVANKRLNEIF
                     AIEPESTNQHPDRVVTNQTFQKGITLEGVSFSYNMKAPTLSNLSCTILPHSKVALVGVS
                     GSGKSTMAKLLVNFYPPSEGTIRYGRINHLDIPFHQLRDRVTYIPQESFFFSGSIIENL
                     TFSLDTPPSFERIMEVCDAVQLGTFINQQPLRYDTILEEGGTNISGGQRQRLAIARALL
                     KDADILILDEATSGLDTLLEHAILDYLINLEEKTLIFIAHHLSIAKACNQILVLNDGKL
                     VEQGTHSDLRYNQGVYQQLWDI"
     aSDomain        complement(4246..6363)
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2245_0023"
                     /evalue="2.30E-251"
                     /identifier="TIGR01193"
                     /label="ctg1_2245"
                     /locus_tag="ctg1_2245"
                     /protein_end="714"
                     /protein_start="8"
                     /score="834.2"
                     /tool="antismash"
                     /translation="QQDEKDCGVACIAMILKHYKTEIPIHKLRDFSGTDLEGTSAFGLK
                     KTFEKLFFDCPAIQADNDVWKEKELPLPLIAHILIDNSYMHYVVVYKINGETLSIDDPA
                     RGKIKKTVEEFAKEWTGILLLPTPKDSYVPSKEKVARISSFLPVIWLQKGFVFHIIVAS
                     IFITLFGIGSSYYFQGILDYFIPNHARSTLNIVSVGLIVVYLFRVMFEYSRNYLLVILG
                     QRMSMVVMLQYFKHILSLPMNFFATRKSGEIISRFLDANKIIDALASATLSVFLDIGMV
                     LIVGITLAVQNGILFLITLASLPFYLVSILAFVKSYEKANQEEMVAGATLNSSIIESLK
                     GIETIKAYSGEEKVYHQVDREFVQLMKKSFRTATLDNVQQGIKHAIQLISSALILWLGS
                     YYVMEGSISLGQLITYNALLVFFTDPLQNIINLQVKMQTAQVANKRLNEIFAIEPESTN
                     QHPDRVVTNQTFQKGITLEGVSFSYNMKAPTLSNLSCTILPHSKVALVGVSGSGKSTMA
                     KLLVNFYPPSEGTIRYGRINHLDIPFHQLRDRVTYIPQESFFFSGSIIENLTFSLDTPP
                     SFERIMEVCDAVQLGTFINQQPLRYDTILEEGGTNISGGQRQRLAIARALLKDADILIL
                     DEATSGLDTLLEHAILDYLINLEEKTLIFIAHHLSIAKACNQILVLNDGKLVEQGTHSD
                     LRYNQGVYQQLW"
     PFAM_domain     complement(4444..4896)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2245_0107"
                     /evalue="4.20E-29"
                     /label="ctg1_2245"
                     /locus_tag="ctg1_2245"
                     /protein_end="648"
                     /protein_start="497"
                     /score="101.9"
                     /tool="antismash"
                     /translation="LSNLSCTILPHSKVALVGVSGSGKSTMAKLLVNFYPPSEGTIRYG
                     RINHLDIPFHQLRDRVTYIPQESFFFSGSIIENLTFSLDTPPSFERIMEVCDAVQLGTF
                     INQQPLRYDTILEEGGTNISGGQRQRLAIARALLKDADILILDEATS"
     PFAM_domain     complement(5086..5895)
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2245_0106"
                     /evalue="5.50E-56"
                     /label="ctg1_2245"
                     /locus_tag="ctg1_2245"
                     /protein_end="434"
                     /protein_start="164"
                     /score="190.3"
                     /tool="antismash"
                     /translation="FHIIVASIFITLFGIGSSYYFQGILDYFIPNHARSTLNIVSVGLI
                     VVYLFRVMFEYSRNYLLVILGQRMSMVVMLQYFKHILSLPMNFFATRKSGEIISRFLDA
                     NKIIDALASATLSVFLDIGMVLIVGITLAVQNGILFLITLASLPFYLVSILAFVKSYEK
                     ANQEEMVAGATLNSSIIESLKGIETIKAYSGEEKVYHQVDREFVQLMKKSFRTATLDNV
                     QQGIKHAIQLISSALILWLGSYYVMEGSISLGQLITYNALLVFFTDPL"
     PFAM_domain     complement(5974..6378)
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2245_0105"
                     /evalue="2.00E-44"
                     /label="ctg1_2245"
                     /locus_tag="ctg1_2245"
                     /protein_end="138"
                     /protein_start="3"
                     /score="150.7"
                     /tool="antismash"
                     /translation="FTHIQQQDEKDCGVACIAMILKHYKTEIPIHKLRDFSGTDLEGTS
                     AFGLKKTFEKLFFDCPAIQADNDVWKEKELPLPLIAHILIDNSYMHYVVVYKINGETLS
                     IDDPARGKIKKTVEEFAKEWTGILLLPTPKD"
     CDS             complement(6417..7163)
                     /locus_tag="ctg1_2246"
                     /transl_table=11
                     /translation="MTYPIIICEDQIIQLQQIETIIQNFALFHSELFQISLKTQSPDEV
                     ENYLKKFKPKQGIYFLDIDLNHTTNGIDLAEKIRVQDVQAKIIFITTHDEMIPLTIKRR
                     VETLGFVIKDQPLDNYRSEIVELLLLAQQRIDAAKVSSNQAFIFSIGSQTFTLDLQDIY
                     FLEPSKLPHRLTLYTKSGQYEFYGKLVDLEKKYTTLSKINRSCLANLINAKEVNFKTRA
                     VYFESDLVRLFALGKAKQIKEKLNEQ"
     PFAM_domain     complement(6429..6707)
                     /aSDomain="LytTR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04397.17"
                     /description="LytTr DNA-binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2246_0109"
                     /evalue="4.30E-12"
                     /label="ctg1_2246"
                     /locus_tag="ctg1_2246"
                     /protein_end="245"
                     /protein_start="152"
                     /score="46.2"
                     /tool="antismash"
                     /translation="QTFTLDLQDIYFLEPSKLPHRLTLYTKSGQYEFYGKLVDLEKKYT
                     TLSKINRSCLANLINAKEVNFKTRAVYFESDLVRLFALGKAKQIKEKL"
     PFAM_domain     complement(6807..7151)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2246_0108"
                     /evalue="1.30E-10"
                     /label="ctg1_2246"
                     /locus_tag="ctg1_2246"
                     /protein_end="119"
                     /protein_start="4"
                     /score="41.5"
                     /tool="antismash"
                     /translation="IIICEDQIIQLQQIETIIQNFALFHSELFQISLKTQSPDEVENYL
                     KKFKPKQGIYFLDIDLNHTTNGIDLAEKIRVQDVQAKIIFITTHDEMIPLTIKRRVETL
                     GFVIKDQPLDN"
     CDS             complement(7177..8466)
                     /locus_tag="ctg1_2247"
                     /transl_table=11
                     /translation="LIIIDTKAYLLRMLLNIFILYFLILFITKDEAKPSKYVKILVLIP
                     ITFFVELFTDFSDLVPMLSSYFLLKEKGKKEIILLNKLILCLIVSYSISIISSLMMVNK
                     LFGGINDYTYVTVQIIFECLLVTLFILLYKKLGIQEIIVKYSSITTFMCMIYLWGISFF
                     VSYTAHQYKVFDQFIIGVSVFLVVQIIFICILGVQTTKKQKEKFEKQFKEQELIHLKKY
                     TDQLEQSQEKLNKFKHDYKNLLLSLKEISFLKKDSDFSKQVQALDEYSNHYLAKDISSN
                     SQQLKNIKNSYLKSLFISKIYQANEHDLDIKLECNQTIELIPIPIFDCVRILGIVFDNA
                     IEAAKESEDQKISLMIYQDPSQLEFLLENSCKKTNIPIRKLMEKGISTKVDHKGLGLNT
                     IQEINEKTKNMFIQYKMKDCTFTTSIILIW"
     PFAM_domain     complement(7186..7488)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2247_0110"
                     /evalue="7.50E-16"
                     /label="ctg1_2247"
                     /locus_tag="ctg1_2247"
                     /protein_end="427"
                     /protein_start="326"
                     /score="58.0"
                     /tool="antismash"
                     /translation="FDCVRILGIVFDNAIEAAKESEDQKISLMIYQDPSQLEFLLENSC
                     KKTNIPIRKLMEKGISTKVDHKGLGLNTIQEINEKTKNMFIQYKMKDCTFTTSIIL"
     CDS             complement(8509..8652)
                     /locus_tag="ctg1_2248"
                     /transl_table=11
                     /translation="MNDKKYLKLKECSEKKLKQIQGGNKSVIKGNPASNLAQCVFSFFK
                     KC"
     aSDomain        complement(8584..8625)
                     /aSDomain="TIGR01847"
                     /aSTool="tigrfam"
                     /description="bacteriocin_sig: bacteriocin-type signal
                     sequence"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2248_0024"
                     /evalue="5.20E-04"
                     /identifier="TIGR01847"
                     /label="ctg1_2248"
                     /locus_tag="ctg1_2248"
                     /protein_end="23"
                     /protein_start="9"
                     /score="18.4"
                     /tool="antismash"
                     /translation="KECSEKKLKQIQGG"
     CDS             8882..9070
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_II"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2249"
                     /sec_met_domain="Bacteriocin_II (E-value: 5.8e-16,
                     bitscore: 55.5, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTVKELSVKEMQLTTGGKYYGNGVSCNKNGCTVDWSKAIGIIGN
                     NAAANLTTGGAAGWNKG"
     PFAM_domain     8936..9028
                     /aSDomain="Bacteriocin_II"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01721.20"
                     /description="Class II bacteriocin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2249_0111"
                     /evalue="2.00E-12"
                     /label="ctg1_2249"
                     /locus_tag="ctg1_2249"
                     /protein_end="49"
                     /protein_start="18"
                     /score="47.0"
                     /tool="antismash"
                     /translation="KYYGNGVSCNKNGCTVDWSKAIGIIGNNAAA"
     CDS             9312..9608
                     /locus_tag="ctg1_2250"
                     /transl_table=11
                     /translation="MGKLKWFSGGKERSNQAENIITDLLDDLKTDLDNESLKKVLENYL
                     EELKQKGASVPLILSRMNLDISKAIRNDGVTLSDYQSKKLKELTSISNIRYGY"
     PFAM_domain     9354..9575
                     /aSDomain="EntA_Immun"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08951.12"
                     /description="Enterocin A Immunity"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2250_0112"
                     /evalue="2.60E-10"
                     /label="ctg1_2250"
                     /locus_tag="ctg1_2250"
                     /protein_end="88"
                     /protein_start="14"
                     /score="40.5"
                     /tool="antismash"
                     /translation="NQAENIITDLLDDLKTDLDNESLKKVLENYLEELKQKGASVPLIL
                     SRMNLDISKAIRNDGVTLSDYQSKKLKEL"
     CDS             complement(10514..11290)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 121.5; E-value: 7.6e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2251"
                     /transl_table=11
                     /translation="LKPTALVFFDLDGTLLNQHSEVEEEVIEALEAVKAKGGVPIIATG
                     RTNIEFEHIADATGIDSSVSMNGQFITYEGTEVYRNVLPSESLKRLKAATDERELGLSF
                     YTNKWVKTSVENETLHRAYAFIHADIPEIDPKAHLVDDIFMALVLNEDPSHDDYFRTSF
                     PEFSFYRNTPFSMDTIIKGNSKATGIRQLQKAMGLESVPTYAFGDGPNDLEMFQVADYS
                     VAMGNGIAALKERASFISASNIDGGIVKGLDYFNLI"
     PFAM_domain     complement(10538..11272)
                     /aSDomain="Hydrolase_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08282.14"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2251_0113"
                     /evalue="2.40E-49"
                     /label="ctg1_2251"
                     /locus_tag="ctg1_2251"
                     /protein_end="251"
                     /protein_start="6"
                     /score="168.5"
                     /tool="antismash"
                     /translation="VFFDLDGTLLNQHSEVEEEVIEALEAVKAKGGVPIIATGRTNIEF
                     EHIADATGIDSSVSMNGQFITYEGTEVYRNVLPSESLKRLKAATDERELGLSFYTNKWV
                     KTSVENETLHRAYAFIHADIPEIDPKAHLVDDIFMALVLNEDPSHDDYFRTSFPEFSFY
                     RNTPFSMDTIIKGNSKATGIRQLQKAMGLESVPTYAFGDGPNDLEMFQVADYSVAMGNG
                     IAALKERASFISASNIDGGIVKG"
     aSDomain        complement(10538..11275)
                     /aSDomain="TIGR00099"
                     /aSTool="tigrfam"
                     /description="Cof-subfamily: Cof-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2251_0025"
                     /evalue="1.10E-52"
                     /identifier="TIGR00099"
                     /label="ctg1_2251"
                     /locus_tag="ctg1_2251"
                     /protein_end="251"
                     /protein_start="5"
                     /score="177.2"
                     /tool="antismash"
                     /translation="LVFFDLDGTLLNQHSEVEEEVIEALEAVKAKGGVPIIATGRTNIE
                     FEHIADATGIDSSVSMNGQFITYEGTEVYRNVLPSESLKRLKAATDERELGLSFYTNKW
                     VKTSVENETLHRAYAFIHADIPEIDPKAHLVDDIFMALVLNEDPSHDDYFRTSFPEFSF
                     YRNTPFSMDTIIKGNSKATGIRQLQKAMGLESVPTYAFGDGPNDLEMFQVADYSVAMGN
                     GIAALKERASFISASNIDGGIVKG"
     aSDomain        complement(10616..11275)
                     /aSDomain="TIGR01484"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IIB: HAD hydrolase, family IIB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2251_0026"
                     /evalue="1.70E-24"
                     /identifier="TIGR01484"
                     /label="ctg1_2251"
                     /locus_tag="ctg1_2251"
                     /protein_end="225"
                     /protein_start="5"
                     /score="85.1"
                     /tool="antismash"
                     /translation="LVFFDLDGTLLNQHSEVEEEVIEALEAVKAKGGVPIIATGRTNIE
                     FEHIADATGIDSSVSMNGQFITYEGTEVYRNVLPSESLKRLKAATDERELGLSFYTNKW
                     VKTSVENETLHRAYAFIHADIPEIDPKAHLVDDIFMALVLNEDPSHDDYFRTSFPEFSF
                     YRNTPFSMDTIIKGNSKATGIRQLQKAMGLESVPTYAFGDGPNDLEMFQVADYSVAM"
     CDS             complement(11485..12153)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101:phosphoglycerate mutase (Score: 106.5; E-value:
                     2.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2252"
                     /transl_table=11
                     /translation="LGKGCTFYFVRHGETYFNRYMKMQGWSNTPLTKDGRFTVIRSGRG
                     LSDIRFDAAYCSDLSRTKETLEILLEENFTSRNLKIQEMPEFREAFYGSFEGSDVDESW
                     ATISKELGYETADEMREKATLADRMDGTKAADPLHDAEDFLTFWLRVEKGMLQLIEKHR
                     ETDQNILIVAHGNTIRNLLNGIVPELEMPTSVDNASVSVVNYHDGQYHLERFNDTGHFR
                     "
     PFAM_domain     complement(11500..12135)
                     /aSDomain="His_Phos_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00300.24"
                     /description="Histidine phosphatase superfamily (branch 1)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2252_0114"
                     /evalue="3.00E-35"
                     /label="ctg1_2252"
                     /locus_tag="ctg1_2252"
                     /protein_end="218"
                     /protein_start="6"
                     /score="121.8"
                     /tool="antismash"
                     /translation="FYFVRHGETYFNRYMKMQGWSNTPLTKDGRFTVIRSGRGLSDIRF
                     DAAYCSDLSRTKETLEILLEENFTSRNLKIQEMPEFREAFYGSFEGSDVDESWATISKE
                     LGYETADEMREKATLADRMDGTKAADPLHDAEDFLTFWLRVEKGMLQLIEKHRETDQNI
                     LIVAHGNTIRNLLNGIVPELEMPTSVDNASVSVVNYHDGQYHLERFNDT"
     CDS             complement(12337..12954)
                     /locus_tag="ctg1_2253"
                     /transl_table=11
                     /translation="MGNIDVFNRVASKYDTPERSEIAKITAKEIQKHIVNGKDKTAIDY
                     GCGTGLVGLELVADFETLLFADASQSMVEVVETKIEQATIKNAKTLLLDIEEVSNSDIQ
                     VDYIFLVQVLLHVQDIQPLLSNLYKLLKPNGHLLIVDFDYNEQVNSDKVHNGFKQQELI
                     QLMGKIGFVESNAEIFYHGKNIFMNQDASFFILDAAKPVLND"
     PFAM_domain     complement(12538..12825)
                     /aSDomain="Methyltransf_11"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08241.14"
                     /description="Methyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2253_0115"
                     /evalue="7.40E-14"
                     /label="ctg1_2253"
                     /locus_tag="ctg1_2253"
                     /protein_end="139"
                     /protein_start="43"
                     /score="52.3"
                     /tool="antismash"
                     /translation="DYGCGTGLVGLELVADFETLLFADASQSMVEVVETKIEQATIKNA
                     KTLLLDIEEVSNSDIQVDYIFLVQVLLHVQDIQPLLSNLYKLLKPNGHLLI"
ORIGIN
        1 ttaccagggt tgactagttg gacctacagt aaactcattg atattcacat cttctggttg
       61 atcaattgca taagcaacaa tgcttgcaac tcgttctggt gcaataccat atttatcgta
      121 taaactagtc attccctcag ccgtttttga gtctgtaatt ttatcaagta gctctgtatt
      181 aattgcagct ggataaattg ttgctgtgcg aatattagtt ccttcttgcg ccgattccat
      241 tcgtaagact tccatcaaat cacgaatcgc ccatttcgtt gccccataaa cagcaccgcc
      301 tggataagct ttaagtcctg ctaccgatga tgtagtcagt acatgtcccg acttttgctc
      361 aacaaagtaa ggtaagactg ctgccagacc atttagtacc cctttaatat tgatatcaat
      421 catttgatcc cactcatctt ctttaagtgc agacaatggg gaattaggca tgatacccgc
      481 atttaaaaag ataacatcta cttttccata agtcttaata gtaaaatcta ccaatttttg
      541 attatcaatc cgtttcgtta catctgttac aaaataaact gcttcacctg aattttcttt
      601 aattttttca acaattgttt gtagtttttc ttctctacgt gctgctaata ctaattttgc
      661 tcctttttgg gctaataaaa ttgctgttgc ttctccaatt cctgatgagg ctcctgtaat
      721 aattattact ttatctttaa ttgacattat tttcgctcct ttgttacttt tattttacta
      781 atatgacgtt gattgtttct atttctgaaa tgaaatcgag ttgatcaact tccttaactt
      841 tgcctatttt agtatataag taattggtag agaatgtttt ataaaagagg acaaggcaat
      901 ctgaaccata aagcataata tctccttttt taatttcatc tactttttct tcctgtgttg
      961 gcaatatttc tgaaaaataa gcatattttt cattgccatg taaatcattc atttttagat
     1021 ttattggaag tctaacaatt aattcttttg ttgcttgatt agataccaat tcaatttgaa
     1081 agagttgctt gccgattatt atattcataa cagttagctc tccgtttttt tatattcctt
     1141 actcttcttc aatctctcga actactttgg ctggacttcc caccacaata acattatccg
     1201 gaacatcctt cgttacggtt gaatctgcag caacaatcga attttttcca attgtaaccc
     1261 caggtaaaac agtcacattt gccccaagcc atgcgttctt cttaatataa attggctcta
     1321 ctttaattcc gcgtcttttt ttaggagaaa tcaggtgatt cactgtaatt aatctagaac
     1381 ctggacctat caatacttga tcttcaaaag taatgccacc taaatcgaca aatgttacat
     1441 tttgattgat aaaaatatct tttccaaatc tgatatgttt accgaaatca ctatagaaag
     1501 gttgtgaaat ttttaccgat gagtcaattt tttgacttgt aattttctct agatgtttta
     1561 aaacttcctc attaggataa tagtctgcat ttaacatcat tagcaatcgc tcattatttt
     1621 tcttcactga atggatttct tcaaataagg gtgaatcttt tactatttct tttcctataa
     1681 tcttctgtaa taaacttatg tttgacattt cttttcccct ccttacctat ttattaactt
     1741 tctactatct aaattatact tgaatcagtt atacttaact aataccaata aaacatggtt
     1801 aactattctt tttagctata ggaaggagta ttaaatggaa ctacgcgtgt taacttactt
     1861 tttaactgtt gcaagagaga aaacaattag taaagcggct gaagtcttac atttatctca
     1921 gccaactctt tcaaaacaat taaaagaatt agaagaagag ttaagtgtca cactatttat
     1981 tcgcggaaat cgatttatca cattaacgga ggatggcatc tatttaatga atagaggaaa
     2041 agaaatttta tctttggttg agtcaacaac aacgaacctt attaaaaatg aagtgattag
     2101 tggagaatta acgattggcg gtggtgaatc acaagcattt gattttctta gtcgtatttt
     2161 acatggactt aggaacgatt acccagaaat taatatccac ctttacagtg gaaatgctga
     2221 tgatgtattg gaaaaaattg ataaagggct tttagatttt ggactcgtta ttgaccccgt
     2281 agaaaaacaa aaatacgaat atatccgact acctttagtt gattcgtggg gaattttagt
     2341 caataattca catcctatag cttataaaaa aacagtcaca ccaaaagata ttcaacaaac
     2401 tcctttgctt atttcaaatc aatcttttgt tgataaccag ctttctgaat ggtttggagg
     2461 aaatatagag catctgaatg ttattggcac atataaccta ctttataatg cttcattgtt
     2521 ggtaaaagag ggagttgcaa gtgtactttg tattgatggt attgtgaata cggcgaatac
     2581 aaacctaacc tttgttccct tttctccccc gttaacggca aatattaata ttgtttggaa
     2641 aaagggccaa atattttcaa gtgcttcaaa ggaatttcta cgtttactga agttggttta
     2701 gcattctact tgtttaagtc gatatttcat acattttcct aaaacatttt gcactcttta
     2761 ttttttctag tcttttgtat aaaaacaaaa agagctaaaa acggatttaa atcaaccctt
     2821 atagcccttt tagtttattc tggtttgtac taaatatgga gatgagggga gctttgactg
     2881 tgtaatgaga tttataaatc tatgtaagct taattgactt aatttcaata aattctactc
     2941 tgcatttaaa caagtttaaa tgcaaatgat actcgaagaa ttttgattaa tatttggtca
     3001 tgtatcaatg aaaaaattaa atagtaagtt actaaaataa tggtataccc tatcctcata
     3061 atctttatgt taataattgt caaaataaaa cacttaactt ttaatttaag atactatttc
     3121 tagattaata atgtgttgtt ttacttaaag taaaacaaca cattattttt ttagatacaa
     3181 tagcatacga catgatctaa attttatttt attaattcct tcaggtatta cacaaacttt
     3241 attcttgatt tagcaacaca tctttgattt gttgccaata gctttttttt ccaataatga
     3301 gcgaaacttc ccctgtcata ccatatctat tattaaaata ttttgaagat tgtaacgtac
     3361 cttttattgt gtagaaggtt ccttgttcag ttgtcatact agtctctgaa atctctttta
     3421 gagttccctc aattgtttgg gatgcaacac cttttttatc taatttaaaa tgaacgtcca
     3481 tacctacttt tattcgtgtt acttcatcag caggtaatag cgcagtaaac attagctgtg
     3541 attctttttg ctttggatag atttctgcaa gtaccgttcc ttttgataca tctatttggc
     3601 ctgttacttc ctcattcaag tgaactattc cagttgaagg agattttaat gttcctcgta
     3661 caagctgttc agttatattt tgaagggtat agttattttt ttttttggtt tcaattagta
     3721 cggctatctt ttgcttggtt gtagccaaga cttgctctgt attttgtgtt tccttttcga
     3781 gtaataaact ctttagctga ttactgtatc caaattcatc ctcgtcttca aataagttct
     3841 gttctttagc tatactttca ataaatagtt gcgcagcttt cttttggtct tcaagagacg
     3901 tattttcttg ttcaaattgc tccttttcat tttgtaaaac actagtatca aacatcacta
     3961 aaacttctcc ttttttgacc tctttatttt ctttaagatt atttactttg atgtttgctt
     4021 ccagtggtac ttgtagttta tctattttag ttgcggttag ttgagcaggt acccgaacga
     4081 caacttcttt tttcgcaaaa gccaaaaata aactaaccaa aaacaaaaaa agaattacag
     4141 gatataacac ccaacgataa aatttttgat gctgttgact atatacactg gagtggtcgc
     4201 gccagttatt attatgcata atttagcctt ccttttttaa atatcccata actgttgata
     4261 aactccctga ttatatcgca aatcgctgtg cgtaccttgc tctactaatt ttccatcgtt
     4321 gagtactaaa atttgattac aggctttggc tattgataaa tgatgagcaa tgaaaatcaa
     4381 ggttttttct tctaaattta ttaagtagtc taatatggca tgttctaaga gtgtatccag
     4441 tccactggtc gcctcatcta agattaggat gtcggcgtcc ttcaataaag cacgagcaat
     4501 agctaatctt tgacgttgcc caccagaaat attggtccca ccctcctcta gtatcgtgtc
     4561 ataacgtaaa ggttgttgat taataaatgt acccaattga actgcatcac aaacttccat
     4621 tattcgttca aaactaggtg gtgtatccaa gctaaatgtt aaattttcaa tgatagatcc
     4681 gctgaaaaaa aatgattctt gaggaatata ggttactcgg tcacgtaatt gatgaaaagg
     4741 aatatctaga tgattgatac ggccataacg aattgttcct tcagatgggg gataaaaatt
     4801 cactagtaat tttgccatgg tagattttcc agatccacta acaccaacta aggcaacctt
     4861 gctatgtggt agaatcgtac aagagagatt gctcaacgtt ggagctttca tgttgtaaga
     4921 aaatgaaacc ccttccaagg tgattccctt ttgaaatgtt tgatttgtaa caacacggtc
     4981 agggtgttga ttagttgatt caggctcgat agcaaaaatt tcatttaagc gtttattagc
     5041 aacttgggct gtctgcattt tcacttgtaa gttaataata ttttgcaaag gatcagtaaa
     5101 aaaaacaagt aaggcattat aagtaataag ttggcctagg ctaatcgacc cttccataac
     5161 ataataagaa cctagccaca aaattaatgc actactgatt aactgaatag catgtttaat
     5221 accttgctga acattatcta atgtcgccgt acgaaaagac tttttcatta gttgaacaaa
     5281 ttctctatcg acttgatgat aaaccttttc ttcaccgctg tatgccttaa tagtctcaat
     5341 ccccttaaga ctttcaataa tactagaatt taatgttgca ccagcaacca tttcttcttg
     5401 atttgctttt tcatagcttt taacaaaagc taaaatagaa actagataaa aaggtaatga
     5461 agccaatgta attaaaaata agatgccatt ttgaacggct aacgtaatcc ctactattaa
     5521 gaccatgcca atatctaaaa aaaccgacaa agtggcactt gctaaagcat caatgatttt
     5581 attagcatca agaaaacgtg aaatgatttc acctgattta cgagtagcaa aaaaattcat
     5641 tggtaaggaa agtatatgtt taaagtactg aagcatgacc accatactca ttcgttgccc
     5701 caatataact aagagataat ttcgactata ttcaaacatg acacgaaata aataaacaac
     5761 aattaaaccg acagatacaa tatttaatgt agaacgagca tgatttggaa taaaatagtc
     5821 tagaattcct tgaaaatagt aagaacttcc tataccgaac aaagtaataa aaattgatgc
     5881 tactataatg tgaaaaacaa aacctttttg cagccaaata actggtaaaa aagagcttat
     5941 tctcgcaact ttttctttac ttgggacgta actatctttt ggagtaggta ataataaaat
     6001 acctgtccat tctttagcaa attcttcaac tgtttttttt attttccccc tagcaggatc
     6061 atcaatagat aatgtttctc catttatctt atagacaact acatagtgca tatagctatt
     6121 atcaatcaag atgtgcgcaa ttaaaggtag gggtaattct ttttctttcc acacatcgtt
     6181 atcagcttgg atagcaggac aatcaaaaaa taacttttca aacgttttct ttaatccaaa
     6241 agccgatgtg ccttctaagt cagttcctga aaaatcacgt aatttgtgaa tgggaatttc
     6301 tgttttgtaa tgttttaaaa tcattgctat acatgctaca ccacaatctt tttcatcttg
     6361 ttgctgaata tgagtaaatt gtttcattac gatacagcgg tcctttcaaa attaagttac
     6421 tgttcattta atttttcttt aatttgcttt gccttaccta atgcaaaaag ccttactaag
     6481 tcagactcaa aataaacagc acgcgtttta aaattaactt cttttgcatt aattaaattc
     6541 gctaagcagg atcgattaat tttggataaa gtagtgtatt ttttttctaa atcaactaac
     6601 tttccataaa attcatattg tccactttta gtatataggg ttaatctatg gggtagctta
     6661 gaaggttcta aaaaataaat atcttgtaaa tcaagagtaa atgtttgaga tccgatagaa
     6721 aaaataaatg cttgatttga actaaccttt gccgcatcaa ttctttgttg agcaaggagt
     6781 agtaactcga caatttctga ccgataatta tccaaaggtt gatcttttat cacaaatcct
     6841 aatgtttcca cacgcctttt gatagttaaa ggaatcattt catcatgcgt tgtaataaaa
     6901 ataatttttg cttggacatc ttgtacacgt attttttctg ccagatcaat tccgttcgta
     6961 gtatgattta aatcaatatc taaaaagtaa attccctgct taggtttaaa ctttttcaaa
     7021 taattttcta cttcatcggg actttgtgtt tttaaactga tttgaaaaag ctcactatga
     7081 aaaagtgcga aattttgaat aattgtttca atttgctgta gttgaatgat ttgatcttcg
     7141 caaataataa tggggtaagt cataatagct cctttcttac caaataagga taatgctagt
     7201 ggtgaacgta cagtctttca ttttatattg aataaacata tttttggtct tttcatttat
     7261 ttcttgaatc gtattcaatc ctaatccttt atggtctact tttgttgaaa ttcctttctc
     7321 catcaacttt ctgataggaa tattcgtttt tttacaacta ttttcgagaa gaaattcaag
     7381 ttgtgaaggg tcttgataaa tcataagaga gattttttga tcttcacttt ctttagccgc
     7441 ttcaattgca ttatcaaaaa caatacccaa tattcttaca caatcaaaaa taggaatagg
     7501 gattagttca atagtttgat tacattccaa tttaatatca agatcatgct cattggcttg
     7561 atatattttt gaaataaaaa ggcttttcaa atatgaattt tttatattct ttaattgttg
     7621 actgttactt gatatatctt tcgcaagata atggttagaa tattcatcta atgcttgaac
     7681 ttgtttcgaa aaatctgagt ctttttttaa gaaagatatc tcttttaaac tgagtaataa
     7741 gtttttataa tcatgtttaa atttatttag cttttcttga ctttgttcca actgatcagt
     7801 gtattttttt aaatgaataa gttcttgttc tttaaactgc ttttcaaact tttctttttg
     7861 cttcttagtt gtttgaactc ctaaaatgca aataaatata atctgcacga caaggaaaac
     7921 tgacacacct ataatgaatt gatcaaatac tttatattga tgagctgtat aagatacgaa
     7981 aaaagaaatt ccccataagt aaatcatgca cataaaagtt gtaatagaac tatactttac
     8041 aatgatttcc tgaattccta gctttttgta taacaaaata aatagagtta ccaagagaca
     8101 ttcaaaaata atttgtacag ttacataggt gtagtcatta atacctccaa ataatttgtt
     8161 taccatcatc aatgaactaa tgattgatat actgtagctt acaattaaac atagaataag
     8221 tttatttaaa agtataattt ccttttttcc tttctctttc aataaaaaat aactgctaag
     8281 catcggtacc aaatcagaaa aatcagtgaa taattccaca aaaaaggtaa tagggataag
     8341 tacaagtatc tttacatatt tactgggttt agcttcatct ttagtaataa atagaattag
     8401 gaaatacaaa ataaaaatat ttagcaacat tcttagtaag tacgcttttg tatcgatgat
     8461 aatcaagaaa atccctcctt gattaaatta taccaaaaat aaaaatcatt agcatttttt
     8521 aaaaaaagaa aaaacacatt gagctaaatt agatgcgggg ttccctttta taactgattt
     8581 attacctccc tgtatttgtt ttaatttttt ttctgaacat tctttcaatt tcaagtattt
     8641 tttatcgttc atttttattc cctccaattt ttttaacagt gatagtatgc catacattta
     8701 attataaaac gaaaaacatt cctgaagcac tagtaaatga ttcttggatg ttacaatcaa
     8761 ttaactttat aagttcatga ataatatcgt gatagttcag gaataaaaaa tctataagta
     8821 aaaaagatgt gatacagtca gcatgttgta aaaaatattt taaaaaggag cgtgtttacg
     8881 catgaaaact gttaaagaac ttagcgttaa agaaatgcaa ctaactacag gaggtaagta
     8941 ttacggaaat ggcgtttcct gtaataaaaa tggttgtact gtagattgga gcaaagctat
     9001 tgggattata ggaaacaatg cagcagcaaa tttgactaca ggtggagccg ctggttggaa
     9061 caaaggataa ttaaagtctc ttatttttta tcttgtaaaa aagatgatac gcatcaatgc
     9121 tgtgacataa catagatggg tctttatatt tgtaagttac atttaaaaca aaaataaata
     9181 tataaaaaga tttttttata gtcttaggaa ttatgttata ctaacaaaaa taggctagtt
     9241 tcaacatgat gtaaagaaac ttatactatc aactaaaatc ataaatatat aaaattaagg
     9301 agtgatattt tatgggtaag ttaaaatggt tttctggagg aaaagaacga tcaaatcagg
     9361 cagaaaacat tatcactgat ttattagatg atttaaaaac agacttagac aacgaatcgc
     9421 taaaaaaagt gttagaaaat tatcttgaag agttaaaaca aaagggcgct tctgttcctc
     9481 tgattttaag tcgaatgaac ttagatattt ctaaagcaat cagaaatgat ggcgttactt
     9541 tatctgacta tcaatcaaaa aaacttaaag agttgacttc tatctccaat attagatatg
     9601 gatattagta ctgcatatac ctatataact cccactatct taattaaatt tgatctattt
     9661 actttaaatc ggcttataaa tttttacgac tagtcataaa aatagttaag aaaataatgc
     9721 cagtaaatat gcgtcaaaat gatcaggtca tagtaaatta ttacaagttt aactatttat
     9781 gaaggtattt taaacagatt agaaaaaagt gaatcggatt ctgtcaattc actaataaca
     9841 aaaatagaat ttttatgtaa attattaaat ttgatttcag tgtacaatta gtgtactgaa
     9901 ataattaaaa ctaactatta ttttaatttc cctaaaacaa aaaaacctat ttaaatcgtt
     9961 gttaaatcaa cgttttaaat aggtttcatt tttaggttat catctaaaat aaccacaata
    10021 tggagacgag gggagtcgaa cccctgtcca agcatatcgg cacttagaca tctacgttca
    10081 tagtcatgct attaaggttt cgctgaacat tagccgccta acaggcatca tgcatcgcta
    10141 gtctgataat ctcttctaaa ctttacagac ggaaaaattt agcgtatccc acttattata
    10201 ggacccttac ccgagcacat gggcgatgcc gggaggatct acgtcaactg tttttaggca
    10261 gctagagcgt aagagttatt attgttttta gcagttatat ttaactggta acgtttttgc
    10321 gtagacgtaa cctacgaaac gcaatccaag ctcgacctac acctgtcgaa tccgtaacgc
    10381 ccccgtaaaa aagctgggtt tagtttgaac ggataggaat gaccttgtgt cttcctaaaa
    10441 tactctctgt tcctattcta acacgaatca ccataaaaaa aaagcagaga tattttttcc
    10501 ctgctagttt tgtctagatt aaattgaaat agtccaaacc tttaacaatt ccaccatcaa
    10561 tattgcttgc cgaaataaaa ctagctcgct cttttaaagc agcaattcca tttcccatcg
    10621 ctactgaata atctgccact tgaaacattt ctaaatcatt aggtccatca ccaaaagcat
    10681 aggttggcac agattctaac cccattgctt tttgtaattg ccgaatccct gttgcttttg
    10741 aattgccttt aataatcgta tccatactaa agggagtatt gcgataaaaa gaaaattctg
    10801 gaaaagaggt tctaaaatag tcatcatgac ttggatcttc atttaaaact aatgccataa
    10861 aaatgtcatc tactaaatga gcttttggat ctatttcagg aatatctgca tgaataaaag
    10921 catatgctct gtggagagtc tcattttcta cacttgtttt cacccattta tttgtataaa
    10981 atgatagccc tagctcacgt tcatccgttg cagcttttaa gcgttttaac gattcgcttg
    11041 gcaaaacatt gcgatacact tcggtgcctt cataagtaat aaactggccg ttcattgaga
    11101 cactagaatc aattccagtc gcatccgcaa tatgctcaaa ttcaatattc gttcgtccgg
    11161 tcgcgataat tggtactccc cccttggctt taactgcctc taaggcctca attacttcct
    11221 cttcaacttc ggaatgttga tttaatagag ttccatctaa atcaaaaaaa actaatgctg
    11281 ttggtttcaa ctatattcct ccttaataaa aagtttgttg agccgggtag gcctggcaga
    11341 aaaatatgga aatttgatgt ggcgcttttt gccacctcga aatttcatct tttttccgaa
    11401 ggactggctc ataaaaacta gcctaaatca attcttataa ctagagaaaa gcgctaggaa
    11461 ttccccctaa cgctacattt atttctatct aaaatgtcct gtatcattaa agcgctctag
    11521 gtgatactgg ccatcatgat aattcacaac tgaaacgctg gcattgtcaa cagaagtcgg
    11581 catttctaat tcaggtacaa ttccatttaa cagattccga atcgtatttc catgagcgac
    11641 aatcaaaata ttttgatccg tctcacgatg cttttcaatc agttgcaaca tgcctttttc
    11701 aacacgtaac caaaaagtta aaaaatcttc tgcatcatgt aagggatcag ctgcttttgt
    11761 accatccatt cgatcggcta aagtcgcttt ttcacgcatc tcatctgccg tttcataacc
    11821 taattcctta ctaattgttg cccagctttc gtccacatca gaaccttcaa aagagccata
    11881 gaatgcttct ctaaattcag gcatttcttg aatttttaaa ttacgtgaag tgaaattttc
    11941 ttctaataaa atctctaacg tttctttcgt ccgacttaaa tcactacaat aagcagcatc
    12001 aaaacgaata tccgataaac ctctgccgct tctaatcaca gtaaaacgac catcttttgt
    12061 taatggagtg tttgaccacc cttgcatttt catataacga ttaaaataag tttccccatg
    12121 tctgacaaaa taaaatgtac atccttttcc caaaataaat ctcctccagt ttctaaaaac
    12181 catacgctta actactaaaa tacttacatt gaaaataaaa tgcctctata aaaagcaact
    12241 tgaacttatt tcctaccttt actattgtaa caaactggca aagttttgct agcttttttt
    12301 agaaataatt atcttaatac tacatggtgc gcacttctaa tcgtttaaaa caggcttagc
    12361 tgcatctaaa ataaagaatg aggcatcctg attcataaaa atattcttcc catgataaaa
    12421 tatttcagca ttcgattcta caaatccaat ttttcccatt agttgaatga gctcttgctg
    12481 tttaaagcca ttatgaactt tatctgaatt aacctgttcg ttataatcaa aatcaacaat
    12541 caacaaatga ccattcggct ttaataattt atataaattt gatagtaagg gttgaatatc
    12601 ttgtacatga agaagcactt gtactaaaaa gatataatct acttgtatat cactatttga
    12661 cacctcttca atatctaaaa gaagggtttt agcattttta atagtagcct gttcaatttt
    12721 tgtttccaca acctctacca tactttgaga ggcatccgca aaaagaagtg tctcaaaatc
    12781 agctaccaat tccagtccaa ctaggcctgt tccacagcca taatcaatcg ctgttttatc
    12841 ttttccattc acaatatgct tttggatttc tttagctgtg atttttgcaa tttcacttct
    12901 ctcaggtgta tcgtacttac tagctactcg attaaataca tcaatattcc ccat
//
