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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP031421.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NAPAA | 810,803 | 844,681 |
Region 2 | betalactone | 1,040,325 | 1,067,588 | microansamycin | Polyketide | 7%
Region 3 | terpene | 1,673,457 | 1,694,341 | carotenoid | Terpene | 21%
Region 4 | T3PKS | 2,739,430 | 2,780,593 |

NZ_CP031421.1 - Region 1 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 810,803 - 844,681 nt. (total: 33,879 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and PP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.22 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001399.1 |  | 0.21 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000427.1 |  | 0.20 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000204.1 |  | 0.19 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001591.1 |  | 0.19 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.19 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000637.1 |  | 0.19 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0001768.1 |  | 0.18 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4
BGC0001135.1 |  | 0.18 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001168.1 |  | 0.18 | NRP | livipeptin | Streptomyces lividans 1326

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.55 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001399.1 |  | 0.53 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000427.1 |  | 0.53 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000204.1 |  | 0.51 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001591.1 |  | 0.51 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.51 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000637.1 |  | 0.50 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0001768.1 |  | 0.50 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4
BGC0001135.1 |  | 0.50 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001168.1 |  | 0.50 | NRP | livipeptin | Streptomyces lividans 1326

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 810802 - 844681:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_777: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (21..397): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAESIGtVvK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      80% (moderate)

NZ_CP031421.1 - Region 2 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,040,325 - 1,067,588 nt. (total: 27,264 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000649.1 |  | 0.22 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001935.1 |  | 0.19 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.19 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001897.1 |  | 0.18 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001483.1 |  | 0.18 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0000698.1 |  | 0.18 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0001910.1 |  | 0.17 | Terpene | cyslabdan | Streptomyces cyslabdanicus
BGC0001911.1 |  | 0.17 | Terpene | raimonol | Streptomyces anulatus
BGC0001456.1 |  | 0.17 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.1 |  | 0.17 | Terpene | carotenoid | Streptomyces avermitilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000649.1 |  | 0.55 | Terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001935.1 |  | 0.51 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001487.1 |  | 0.51 | Other | 3,7-dihydroxytropolone | Streptomyces cyaneofuscatus
BGC0001897.1 |  | 0.49 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001483.1 |  | 0.49 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0000698.1 |  | 0.49 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0001910.1 |  | 0.49 | Terpene | cyslabdan | Streptomyces cyslabdanicus
BGC0001911.1 |  | 0.48 | Terpene | raimonol | Streptomyces anulatus
BGC0001456.1 |  | 0.48 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.1 |  | 0.48 | Terpene | carotenoid | Streptomyces avermitilis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP031421.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,673,457 - 1,694,341 nt. (total: 20,885 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.1 |  | 0.34 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000637.1 |  | 0.24 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000644.1 |  | 0.23 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000645.1 |  | 0.21 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001361.1 |  | 0.17 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0001903.1 |  | 0.16 | Other | neocarazostatin A | Streptomyces sp. MA37
BGC0001910.1 |  | 0.16 | Terpene | cyslabdan | Streptomyces cyslabdanicus
BGC0001140.1 |  | 0.14 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001156.1 |  | 0.14 | Terpene | platencin | Streptomyces platensis
BGC0000636.1 |  | 0.14 | Terpene | carotenoid | Brevibacterium linens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.1 |  | 0.67 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000637.1 |  | 0.57 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0000644.1 |  | 0.56 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000645.1 |  | 0.53 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001361.1 |  | 0.47 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0001903.1 |  | 0.47 | Other | neocarazostatin A | Streptomyces sp. MA37
BGC0001910.1 |  | 0.47 | Terpene | cyslabdan | Streptomyces cyslabdanicus
BGC0001140.1 |  | 0.44 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001156.1 |  | 0.44 | Terpene | platencin | Streptomyces platensis
BGC0000636.1 |  | 0.44 | Terpene | carotenoid | Brevibacterium linens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP031421.1 - Region 4 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,739,430 - 2,780,593 nt. (total: 41,164 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.35 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.35 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.25 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001483.1 |  | 0.22 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0000709.1 |  | 0.22 | Saccharide | neomycin | Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0000843.1 |  | 0.20 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate | Streptomyces clavuligerus ATCC 27064
BGC0000679.1 |  | 0.20 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0001964.1 |  | 0.19 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001591.1 |  | 0.18 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.18 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.68 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0001962.1 |  | 0.68 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.58 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001483.1 |  | 0.55 | Other | 5-isoprenylindole-3-carboxylate β-D-glycosyl ester | Streptomyces sp. RM-5-8
BGC0000709.1 |  | 0.54 | Saccharide | neomycin | Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0000843.1 |  | 0.53 | Other (Non-NRP beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate | Streptomyces clavuligerus ATCC 27064
BGC0000679.1 |  | 0.52 | Terpene | diazepinomicin | Micromonospora sp. M42
BGC0001964.1 |  | 0.51 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001591.1 |  | 0.50 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.50 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names