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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7

### Identified secondary metabolite regions using strictness 'relaxed'

NC_010334.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | arylpolyene | 411,309 | 455,200 | APE Vf | Other | 45%
Region 2 | RRE-containing | 1,025,209 | 1,045,595 |
Region 3 | RiPP-like | 1,900,775 | 1,906,175 |
Region 4 | betalactone | 2,506,246 | 2,533,979 |
Region 5 | betalactone | 3,515,438 | 3,545,194 | fengycin | NRP | 13%
Region 6 | hglE-KS,PUFA | 3,633,092 | 3,689,652 | eicosapentaenoic acid | Other | 88%
Region 7 | RiPP-like | 5,097,402 | 5,108,286 |

NC_010334.1 - Region 1 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 411,309 - 455,200 nt. (total: 43,892 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.31 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.28 | Other | APE Ec | Escherichia coli CFT073
BGC0000231.1 |  | 0.24 | Polyketide | griseusin | Streptomyces griseus
BGC0001895.1 |  | 0.24 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000889.1 |  | 0.24 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0002000.1 |  | 0.23 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000234.1 |  | 0.23 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.22 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000237.1 |  | 0.22 | Polyketide | lactonamycin Z | Streptomyces sanglieri
BGC0000194.1 |  | 0.22 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002008.1 |  | 0.65 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.61 | Other | APE Ec | Escherichia coli CFT073
BGC0000231.1 |  | 0.58 | Polyketide | griseusin | Streptomyces griseus
BGC0001895.1 |  | 0.57 | Polyketide | huanglongmycin A, huanglongmycin B, huanglongmycin C | Streptomyces sp. CB09001
BGC0000889.1 |  | 0.57 | Other | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0002000.1 |  | 0.56 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0000234.1 |  | 0.56 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000228.1 |  | 0.55 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0000237.1 |  | 0.55 | Polyketide | lactonamycin Z | Streptomyces sanglieri
BGC0000194.1 |  | 0.55 | Polyketide | actinorhodin | Streptomyces coelicolor A3(2)

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_010334.1 - Region 2 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,025,209 - 1,045,595 nt. (total: 20,387 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001127.1 |  | 0.05 | NRP | jagaricin | Janthinobacterium agaricidamnosum
BGC0001379.1 |  | 0.04 | NRP | BD-12 | Streptomyces luteocolor

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001127.1 |  | 0.21 | NRP | jagaricin | Janthinobacterium agaricidamnosum
BGC0001379.1 |  | 0.18 | NRP | BD-12 | Streptomyces luteocolor

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_010334.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,900,775 - 1,906,175 nt. (total: 5,401 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.18 | Other | nucleocidin | Streptomyces calvus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001387.1 |  | 0.49 | Other | nucleocidin | Streptomyces calvus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_010334.1 - Region 4 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,506,246 - 2,533,979 nt. (total: 27,734 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.20 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001302.1 |  | 0.19 | Other | lomofungin | Streptomyces lomondensis
BGC0000938.1 |  | 0.19 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000805.1 |  | 0.18 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001133.1 |  | 0.18 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0000891.1 |  | 0.16 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000686.1 |  | 0.16 | Terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001739.1 |  | 0.16 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000204.1 |  | 0.15 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000220.1 |  | 0.15 | Polyketide | enterocin | Streptomyces maritimus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.53 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001302.1 |  | 0.52 | Other | lomofungin | Streptomyces lomondensis
BGC0000938.1 |  | 0.52 | Other (Aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000805.1 |  | 0.50 | Saccharide | moenomycin | Streptomyces viridosporus ATCC 14672
BGC0001133.1 |  | 0.50 | NRP | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0000891.1 |  | 0.47 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000686.1 |  | 0.47 | Terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001739.1 |  | 0.46 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0000204.1 |  | 0.46 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000220.1 |  | 0.45 | Polyketide | enterocin | Streptomyces maritimus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_010334.1 - Region 5 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,515,438 - 3,545,194 nt. (total: 29,757 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.29 | Other | showdomycin | Streptomyces showdoensis
BGC0000234.1 |  | 0.25 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002000.1 |  | 0.23 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0001465.1 |  | 0.23 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0000890.1 |  | 0.22 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0001444.1 |  | 0.22 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.22 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0002016.1 |  | 0.21 | Polyketide | lugdunomycin | Streptomyces sp. QL37
BGC0000236.1 |  | 0.21 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0000679.1 |  | 0.20 | Terpene | diazepinomicin | Micromonospora sp. M42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.63 | Other | showdomycin | Streptomyces showdoensis
BGC0000234.1 |  | 0.58 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002000.1 |  | 0.56 | Polyketide | setomimycin | Streptomyces aurantiacus JA 4570
BGC0001465.1 |  | 0.56 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0000890.1 |  | 0.56 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0001444.1 |  | 0.55 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0001538.1 |  | 0.55 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0002016.1 |  | 0.54 | Polyketide | lugdunomycin | Streptomyces sp. QL37
BGC0000236.1 |  | 0.53 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0000679.1 |  | 0.53 | Terpene | diazepinomicin | Micromonospora sp. M42

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NC_010334.1 - Region 6 - PUFA,hglE-KS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,633,092 - 3,689,652 nt. (total: 56,561 nt) Show pHMM detection rules used
hglE-KS: (hglE or hglD)
PUFA: PUFA_KS

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hglE-KS | PUFA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000861.1 |  |  | 0.93 | Other | eicosapentaenoic acid | Shewanella sp. BR-2
BGC0000862.1 |  |  | 0.86 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0001338.1 |  |  | 0.51 | Polyketide | citrinin | Monascus ruber
BGC0000863.1 |  |  | 0.49 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0000284.1 |  |  | 0.48 | Polyketide | phenolic lipids | Azotobacter vinelandii DJ
BGC0000869.1 |  |  | 0.45 | Other | heterocyst glycolipids | Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0000865.1 |  |  | 0.43 | Other | eicoseicosapentaenoic acid | Photobacterium profundum SS9
BGC0001872.1 |  |  | 0.42 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0000864.1 |  |  | 0.40 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0000774.1 |  |  | 0.37 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000861.1 |  | 0.76 | Other | eicosapentaenoic acid | Shewanella sp. BR-2
BGC0000862.1 |  | 0.75 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0001338.1 |  | 0.60 | Polyketide | citrinin | Monascus ruber
BGC0000863.1 |  | 0.58 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0000284.1 |  | 0.57 | Polyketide | phenolic lipids | Azotobacter vinelandii DJ
BGC0000869.1 |  | 0.56 | Other | heterocyst glycolipids | Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0000865.1 |  | 0.55 | Other | eicoseicosapentaenoic acid | Photobacterium profundum SS9
BGC0001872.1 |  | 0.54 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0000864.1 |  | 0.52 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001927.1 |  | 0.52 | Other | A-94964 | Streptomyces sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3633091 - 3689652:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 3633091 - 3681389:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_3076: mal
  PKS_AT (606..919): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 79.2%
    inactive: 70.8%
    2-Rhyd-Malonyl-CoA: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 86.4
    inactive: 38.4
    Methoxymalonyl-CoA: 34.3
    Methylmalonyl-CoA: 27.7
    Isobutyryl-CoA: 18.8
    CHC-CoA: 18.1
    fatty_acid: 17.8
    Propionyl-CoA: 12.0
    trans-1,2-CPDA: 0.0
    Ethylmalonyl-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_3077: pk
  PKS_AT (385..693): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: trans-1,2-CPDA
  Prediction, score:
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Malonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

NC_010334.1 - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 5,097,402 - 5,108,286 nt. (total: 10,885 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.16 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000790.1 |  | 0.14 | Saccharide | O-antigen | Escherichia coli
BGC0000789.1 |  | 0.13 | Saccharide | O-antigen | Escherichia coli
BGC0000786.1 |  | 0.13 | Saccharide | O-antigen | Edwardsiella ictaluri 93-146
BGC0001241.1 |  | 0.08 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.08 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0000807.1 |  | 0.07 | Saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0001573.1 |  | 0.07 | Alkaloid | dihydrolysergic acid | Claviceps africana
BGC0000811.1 |  | 0.06 | Alkaloid | fumigaclavine C | Aspergillus fumigatus Af293
BGC0001205.1 |  | 0.03 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.1 |  | 0.46 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000790.1 |  | 0.43 | Saccharide | O-antigen | Escherichia coli
BGC0000789.1 |  | 0.42 | Saccharide | O-antigen | Escherichia coli
BGC0000786.1 |  | 0.41 | Saccharide | O-antigen | Edwardsiella ictaluri 93-146
BGC0001241.1 |  | 0.31 | Terpene | ergotamine | Claviceps fusiformis
BGC0001267.1 |  | 0.31 | Terpene | lysergic acid, elymoclavine | Claviceps fusiformis
BGC0000807.1 |  | 0.30 | Saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0001573.1 |  | 0.28 | Alkaloid | dihydrolysergic acid | Claviceps africana
BGC0000811.1 |  | 0.25 | Alkaloid | fumigaclavine C | Aspergillus fumigatus Af293
BGC0001205.1 |  | 0.17 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names