LOCUS       NC_015875.1            18311 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_015875.1 Streptococcus pseudopneumoniae IS7493, complete
            sequence.
ACCESSION   NC_015875
VERSION     NC_015875.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 15:01:06
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1538824
            Orig. end    :: 1557135
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..336
                     /locus_tag="ctg1_1526"
                     /transl_table=11
                     /translation="MKIKEQTRKLAAGCSKHRFEVVNRTDEVSSKHCFEVVDRTDEVSS
                     KHRFEVADRTDEVSNHIYGKATLTRFEEIFEEYKNPQDTFFYPLVYKENTYEKNCYFYL
                     CSPSIRS"
     protocluster    1..18311
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1546784:1547900](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7961..9076
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..18311
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18311
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="6"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             287..550
                     /locus_tag="ctg1_1527"
                     /transl_table=11
                     /translation="MKKTAISIFALLVLGASCLFLFSQQSYKKTVVQYYAKDQNLPNRI
                     TYSEYSDKREANYGGTLNITSIKQANDGVYATYGGQLTPFQY"
     CDS             674..1303
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     136.6; E-value: 1.2e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1528"
                     /transl_table=11
                     /translation="MKIHKTVNPVAYENTYYLEGEKHLIVVDPGSHWEAIRQTIENLNK
                     PICAILLTHAHYDHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMADV
                     VTKPAEHTFVFHEEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETIGRT
                     DLPTGSTEQLLHSIQTQLFTLPNYDVYPGHGPATTIAHEKAFNPFF"
     PFAM_domain     710..1252
                     /aSDomain="Lactamase_B"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00753.29"
                     /description="Metallo-beta-lactamase superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1528_0081"
                     /evalue="2.80E-30"
                     /label="ctg1_1528"
                     /locus_tag="ctg1_1528"
                     /protein_end="193"
                     /protein_start="12"
                     /score="105.9"
                     /tool="antismash"
                     /translation="ENTYYLEGEKHLIVVDPGSHWEAIRQTIENLNKPICAILLTHAHY
                     DHIMSLDLVRETFGNPPVYIAESEASWLYTPVDNLSGLPRHDDMADVVTKPAEHTFVFH
                     EEYQLEEFRFKVLPTPGHSIGGVSLVFPDAHLVLTGDALFRETIGRTDLPTGSTEQLLH
                     SIQTQLFTLPNYDVYPGH"
     CDS             1341..1556
                     /locus_tag="ctg1_1529"
                     /transl_table=11
                     /translation="MKIKEQTRKLAAGCSKHSFEVADKTDEVSSKHCFEVVDRTDEVSS
                     KHRFEVADRTDEVSNIYLRQGEADVV"
     CDS             complement(1717..4455)
                     /locus_tag="ctg1_1530"
                     /transl_table=11
                     /translation="MNKLTKLGIVTFSAVTLSAAVPTLVRAEENVAPQPNVAAKPNVAQ
                     PTPAPKPNGSWVDFSMLDPIAKPKPGKEFSKPAEKPVEEPAPVEKPSTEGNILANGTDE
                     AIAEDKKNAEIEKKYNVDPTNQLPEPGLPIITPEPEQPITDSEEMKKMVAEDLAYKKGA
                     AKTQEEYNKLIAEANEKLWAADGVDIDELIHRLIPEKPGAVPAFSDISVRKYEIQADFL
                     DADLVQKHGYTTESRIDSPKQAEVSSTWNVHDKDSADGILTAKKFSDYTFSHVVKAAAD
                     HPDIDPDPKVVRVSYDAAYALRGSGYKNGKGDNLFRYYFIYTKNKPVEEKPKDPQPAET
                     EKPAEISKPAETVEPTVQPKPAENKPVENKPAETPVPATKPAENPQTEVKPAEQPQPAK
                     PVKPAENAGLQKVPYRNDQPKRWFNNGTGRPTLTTNDLAAPLPTENVEKTSYGWWTAEP
                     DLLHAGSHIKVNTFNSNFNNPMFENGKEIKFKGSGFGDMDSRFKPALVRVKVPELEGMN
                     YEAYTIFYEVPNKNGNPTYGTNRTLQGGGISLTIKSKEKKEDIQVYTLTKDRKLEELYY
                     PGFPSEETNRYDEKTKTHSYNLFGETYDTYVFLFKNPAEKPAEQVKPEVKPSEQPKPDK
                     QPSVPTVPADQPQPAKPEKPAEKPIEKPVVPDTPKPVAPAVPDQPQPAKPEKPTEQPVN
                     PVAPITPITPVTPTLNPAIPNNTRVLSNKAGSVQVHGSEATLKNVSYIKVEETKPTSLE
                     SKDYKAFDIHLYDANGKAIQPNGMVLVSLSADKPVENVYYVAPDGTLQALKFKQDTDKV
                     TFETNHFSIYAMTFKVAASRDNGGSTTPVPVVNSSNTEQKGNDASSTKTQAESLATKTE
                     TISKQVAKTLPNTGENHSILATLFGMLTLTAGLFSFRKESE"
     aSDomain        complement(1729..1818)
                     /aSDomain="TIGR01167"
                     /aSTool="tigrfam"
                     /description="LPXTG_anchor: LPXTG cell wall anchor domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1530_0028"
                     /evalue="1.00E-05"
                     /identifier="TIGR01167"
                     /label="ctg1_1530"
                     /locus_tag="ctg1_1530"
                     /protein_end="909"
                     /protein_start="879"
                     /score="24.0"
                     /tool="antismash"
                     /translation="TLPNTGENHSILATLFGMLTLTAGLFSFRK"
     PFAM_domain     complement(1729..1836)
                     /aSDomain="Gram_pos_anchor"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00746.23"
                     /description="LPXTG cell wall anchor motif"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1530_0082"
                     /evalue="1.20E-06"
                     /label="ctg1_1530"
                     /locus_tag="ctg1_1530"
                     /protein_end="909"
                     /protein_start="873"
                     /score="28.4"
                     /tool="antismash"
                     /translation="SKQVAKTLPNTGENHSILATLFGMLTLTAGLFSFRK"
     CDS             complement(4851..5504)
                     /locus_tag="ctg1_1531"
                     /transl_table=11
                     /translation="MSQKTINIGYARVSTHKQDLGLKVQIEALKHCDKLFIEKESGANN
                     TRPELTKALKLASDFSKDGKQVTFTIYKLDRLTRSMFKLLELIEQFNEYHIQLVSLHEK
                     LETDFLIGRLLCVILGFVAENELENLRFRTKEGLRKAKENGVRLGAKRISKEKEERILN
                     KYLHSNISIRNIAKAEQISTSTLYKVLERNKVANNRQKNGKSLLKIGKNGRMKL"
     PFAM_domain     complement(5067..5483)
                     /aSDomain="Resolvase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00239.23"
                     /description="Resolvase, N terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1531_0083"
                     /evalue="6.50E-31"
                     /label="ctg1_1531"
                     /locus_tag="ctg1_1531"
                     /protein_end="146"
                     /protein_start="7"
                     /score="107.5"
                     /tool="antismash"
                     /translation="IGYARVSTHKQDLGLKVQIEALKHCDKLFIEKESGANNTRPELTK
                     ALKLASDFSKDGKQVTFTIYKLDRLTRSMFKLLELIEQFNEYHIQLVSLHEKLETDFLI
                     GRLLCVILGFVAENELENLRFRTKEGLRKAKENGV"
     CDS             complement(5687..7579)
                     /locus_tag="ctg1_1532"
                     /transl_table=11
                     /translation="MTRYQDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLMLA
                     TTDKWLAGEEVPEDAILANFVKYHRLVRDFDKREADGITPVLPLLKEFQELETFADFTA
                     KLAEFELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELLTLW
                     KESSANLLKAYDFSDEEIEDLLEKRLELDRRVAAVVLSNEEGSEYAKLYHPYSYEDFKK
                     FAPALPLNDFFQAVLGQVPDKVIVDEERFWQAADQFYSEEAWPLLKANLILSVVNLSTS
                     YLTEEIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSPEAKADV
                     EKKVATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYPEELPARYKDKVVNETA
                     SLFENALAFARVEIKHSWSKWNQPVDYKEWGMPAHMVNAYYNPQKNLIVFPAAILQAPF
                     YDLHQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLKDWWTESDYAAFKEKTQKVI
                     DQFDGQDSYGATINGKLTVSENVADLGGIAAALEAAKREADFSAEEFFYNFGRIWRMKG
                     RPEFMKLLASVDVHAPAKLRVNVQVPNFDDFFTTYDVKEGDRMWRSPEERVIIW"
     PFAM_domain     complement(5699..6271)
                     /aSDomain="Peptidase_M13"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01431.23"
                     /description="Peptidase family M13"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1532_0085"
                     /evalue="5.60E-62"
                     /label="ctg1_1532"
                     /locus_tag="ctg1_1532"
                     /protein_end="627"
                     /protein_start="436"
                     /score="209.1"
                     /tool="antismash"
                     /translation="NAYYNPQKNLIVFPAAILQAPFYDLHQSSSANYGGIGAVIAHEIS
                     HAFDTNGASFDENGSLKDWWTESDYAAFKEKTQKVIDQFDGQDSYGATINGKLTVSENV
                     ADLGGIAAALEAAKREADFSAEEFFYNFGRIWRMKGRPEFMKLLASVDVHAPAKLRVNV
                     QVPNFDDFFTTYDVKEGDRMWRSPEERV"
     PFAM_domain     complement(6431..7567)
                     /aSDomain="Peptidase_M13_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05649.15"
                     /description="Peptidase family M13"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1532_0084"
                     /evalue="2.40E-60"
                     /label="ctg1_1532"
                     /locus_tag="ctg1_1532"
                     /protein_end="383"
                     /protein_start="4"
                     /score="205.3"
                     /tool="antismash"
                     /translation="QDDFYDAINGEWQQTAEIPADKSQTGGFVDLDQEIEDLMLATTDK
                     WLAGEEVPEDAILANFVKYHRLVRDFDKREADGITPVLPLLKEFQELETFADFTAKLAE
                     FELAGKPNFLPFGVSPDFMDARINVLWASAPSTILPDTTYYAEEHPQREELLTLWKESS
                     ANLLKAYDFSDEEIEDLLEKRLELDRRVAAVVLSNEEGSEYAKLYHPYSYEDFKKFAPA
                     LPLNDFFQAVLGQVPDKVIVDEERFWQAADQFYSEEAWPLLKANLILSVVNLSTSYLTE
                     EIRVLSGAYSRALSGVPEAKDKVKAAYHLAQEPFKQALGLWYAREKFSPEAKADVEKKV
                     ATMIDVYKERLLKNDWLTPETCKQAIVKLNVIKPYIGYP"
     CDS             7961..9076
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1533"
                     /sec_met_domain="ThiF (E-value: 2.6e-42, bitscore: 141.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 8e-11,
                     bitscore: 39.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLLKARPKLKKAYPVVYKDGSVYIGGFGEITEYEDPSGAIEYML
                     KKMDGINTVEKIIREVSETYSELSPSDVMEAIDEISKERFIEDLNLTGSKILSKYELER
                     YHRNINFFSSYATLSENKYISQKKLIDSKIGIIGLGGLGSHIIYDLAGLGIGEIKAVEF
                     DVVDISNLNRQILYNFDDIGKSKASIAKQRIYEFNPQIKFTVEEKKINSSEDVVESFRG
                     FDCLILVADRPKIKLARWVNEAIVKLNIPLFCAGLEAQRALQYTIIPKISGCIDCWRNT
                     IQKEHPISHLILEERTRLNLVGDNTAIAPLVSVATGIICSEVTKYITGIGELTTVGQLK
                     SIDMNTMTTKIAEHWHIDPNCITCRGGNIIE"
     PFAM_domain     8324..9037
                     /aSDomain="ThiF"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00899.23"
                     /description="ThiF family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1533_0086"
                     /evalue="3.60E-40"
                     /label="ctg1_1533"
                     /locus_tag="ctg1_1533"
                     /protein_end="359"
                     /protein_start="121"
                     /score="137.6"
                     /tool="antismash"
                     /translation="KYISQKKLIDSKIGIIGLGGLGSHIIYDLAGLGIGEIKAVEFDVV
                     DISNLNRQILYNFDDIGKSKASIAKQRIYEFNPQIKFTVEEKKINSSEDVVESFRGFDC
                     LILVADRPKIKLARWVNEAIVKLNIPLFCAGLEAQRALQYTIIPKISGCIDCWRNTIQK
                     EHPISHLILEERTRLNLVGDNTAIAPLVSVATGIICSEVTKYITGIGELTTVGQLKSID
                     MNTMTTKIAEHWHIDP"
     CDS             9186..10262
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 228.6; E-value: 2.1e-69)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1534"
                     /transl_table=11
                     /translation="MATLYGISFLPWILFSLVGGILADKFKKVYIISICHLISLVILSL
                     LIISFKNDNILLLLIYILTFLLSSTEPLVHPAFQSLLPQIVTDNQLSKANSGIQLIDNT
                     LNLIGPMISGSVLLLINPAKVLWVNALTFLIASLLILCIKTPENTLVNISKKESLSKTI
                     SIGLHYVKNDKIILSGAILFFGTNFGIHIFQANLVYYITDVLGYTSFHYGLILSIAGVG
                     AILGAILAPELIKKFRYGKILSISTMLAGLSTMLLSINTNYIYMGVFLGLSNMFGNINA
                     ITYFTLRQKVVKKEMLGRVVSITRMISFASIPLGAYLGGILVSHNLTIISILILAGTIR
                     FLAGGFSYFSPLTKSKNY"
     PFAM_domain     9210..10250
                     /aSDomain="MFS_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF05977.15"
                     /description="Transmembrane secretion effector"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1534_0087"
                     /evalue="7.80E-26"
                     /label="ctg1_1534"
                     /locus_tag="ctg1_1534"
                     /protein_end="355"
                     /protein_start="8"
                     /score="90.7"
                     /tool="antismash"
                     /translation="FLPWILFSLVGGILADKFKKVYIISICHLISLVILSLLIISFKND
                     NILLLLIYILTFLLSSTEPLVHPAFQSLLPQIVTDNQLSKANSGIQLIDNTLNLIGPMI
                     SGSVLLLINPAKVLWVNALTFLIASLLILCIKTPENTLVNISKKESLSKTISIGLHYVK
                     NDKIILSGAILFFGTNFGIHIFQANLVYYITDVLGYTSFHYGLILSIAGVGAILGAILA
                     PELIKKFRYGKILSISTMLAGLSTMLLSINTNYIYMGVFLGLSNMFGNINAITYFTLRQ
                     KVVKKEMLGRVVSITRMISFASIPLGAYLGGILVSHNLTIISILILAGTIRFLAGGFSY
                     FSPLTKS"
     CDS             10734..11456
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 157.3; E-value:
                     8.6e-48)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1535"
                     /transl_table=11
                     /translation="MIRIENLSVSYKETLALKDISLVLHGPTITGIIGPNGAGKSTLLK
                     GMLGIIPHQGQAFLDDKEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPLFR
                     SLKAKHWKKVKEALEIVGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEPFVG
                     IDSVSEEIIMNTLRDLKKAGKTVLIVHHDLSKVPHYFDQVLLVNREVIAFGPTKETFTE
                     TNLKEAYGNRLFFNGGDL"
     PFAM_domain     10782..11216
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1535_0088"
                     /evalue="1.40E-25"
                     /label="ctg1_1535"
                     /locus_tag="ctg1_1535"
                     /protein_end="161"
                     /protein_start="16"
                     /score="90.5"
                     /tool="antismash"
                     /translation="LKDISLVLHGPTITGIIGPNGAGKSTLLKGMLGIIPHQGQAFLDD
                     KEVKKSLHRIAYVEQKINIDYNFPIKVKECVSLGLFPSIPLFRSLKAKHWKKVKEALEI
                     VGLADYAERQISQLSGGQFQRVLIARCLVQEADYILLDEPF"
     CDS             11453..12301
                     /gene_functions="other (smcogs) SMCOG1245:ABC transporter
                     protein, integral membrane (Score: 291.6; E-value:
                     9.1e-89)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1536"
                     /transl_table=11
                     /translation="MIAEFIDGLQKFHFLQNALITAIVVGVVAGAVGCFIILRGMSLMG
                     DAISHAVLPGVALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSSFL
                     ALGIILISVAKSSTDLFHILFGNILAVQDTDMLITMGVGAAILLLIWIFFKQLLITSFD
                     ELLAKAMGMPVNFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANSLKSM
                     IFLSSTFGATASVLGLFIGYSFNVAAGSSIVLTAASFFLISFFIAPKQRYLKLKNKHLL
                     K"
     PFAM_domain     11486..12250
                     /aSDomain="ABC-3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00950.19"
                     /description="ABC 3 transport family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1536_0089"
                     /evalue="4.70E-77"
                     /label="ctg1_1536"
                     /locus_tag="ctg1_1536"
                     /protein_end="266"
                     /protein_start="11"
                     /score="259.1"
                     /tool="antismash"
                     /translation="FHFLQNALITAIVVGVVAGAVGCFIILRGMSLMGDAISHAVLPGV
                     ALSFILGLDFFIGAIVFGLLAAIIITYIKGNSIIKSDTAIGITFSSFLALGIILISVAK
                     SSTDLFHILFGNILAVQDTDMLITMGVGAAILLLIWIFFKQLLITSFDELLAKAMGMPV
                     NFYHYLLMVLLTLVSVTAMQSVGTILIVAMLITPAATAYLYANSLKSMIFLSSTFGATA
                     SVLGLFIGYSFNVAAGSSIVLTAASFFLISFFI"
     CDS             12336..13265
                     /gene_functions="transport (smcogs) SMCOG1252:cation ABC
                     transporter, periplasmic (Score: 292; E-value: 7.4e-89)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1537"
                     /transl_table=11
                     /translation="MKKLGTLLVLFLSVIALVACASGKKDTASGQKLKVVATNSIIADI
                     TKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLV
                     ENAKKTENKDYFAVSEGVDVIYLEGKNEKGKEDPHAWLNLENGIIFAKNIAKQLSAKDP
                     NNKEFYEKNLKEYTDKLDKLDKESKDKFTKIPAEKKLIVTSEGAFKYFSKAYGVPSAYI
                     WEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDS
                     IAEQGKEGDSYYSMMKYNLDKIAEGLAK"
     PFAM_domain     12438..13250
                     /aSDomain="ZnuA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01297.19"
                     /description="Zinc-uptake complex component A periplasmic"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1537_0090"
                     /evalue="4.90E-78"
                     /label="ctg1_1537"
                     /locus_tag="ctg1_1537"
                     /protein_end="305"
                     /protein_start="34"
                     /score="262.3"
                     /tool="antismash"
                     /translation="VVATNSIIADITKNIAGDKIDLHSIVPIGQDPHEYEPLPEDVKKT
                     SEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFAVSEGVDVIYLEGKNEKGKEDP
                     HAWLNLENGIIFAKNIAKQLSAKDPNNKEFYEKNLKEYTDKLDKLDKESKDKFTKIPAE
                     KKLIVTSEGAFKYFSKAYGVPSAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESS
                     VDDRPMKTVSQDTNIPIYAQIFTDSIAEQGKEGDSYYSMMKYNLDKIAE"
     CDS             13388..13879
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196:alkyl hydroperoxide reductase/ Thiol specific
                     (Score: 66.2; E-value: 3.8e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1538"
                     /transl_table=11
                     /translation="MVTFLGNPVSFTGKQLQVGDKALDFSLTTTDLSKKSLADFDGKKK
                     VLSVVPSIDTGICSTQTRRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGIENAIMLS
                     DYFDHSFGRDYALLINEWHLLARAVFVLDTDNTIRYVEYVDNINSEPNFEAAIAAAKAL
                     "
     PFAM_domain     13439..13807
                     /aSDomain="AhpC-TSA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00578.23"
                     /description="AhpC/TSA family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1538_0091"
                     /evalue="2.00E-19"
                     /label="ctg1_1538"
                     /locus_tag="ctg1_1538"
                     /protein_end="140"
                     /protein_start="17"
                     /score="69.8"
                     /tool="antismash"
                     /translation="VGDKALDFSLTTTDLSKKSLADFDGKKKVLSVVPSIDTGICSTQT
                     RRFNEELAGLDNTVVLTVSMDLPFAQKRWCGAEGIENAIMLSDYFDHSFGRDYALLINE
                     WHLLARAVFVLDTDNTIRY"
     CDS             complement(14089..16797)
                     /locus_tag="ctg1_1539"
                     /transl_table=11
                     /translation="MIKRKTYWKDLIQSFTGSKGRFLSILTLMMLGSLALVGLKVTGPN
                     MEATANAYFTTAKTLDLAVMSNYGLDQADQEELEQLEGAEVEFGYLTDVTMANGQDAIR
                     LYSKPERISTFQLREGRLPQSDQEIALASHLQSQYSVGQEISFKEKEGSHSSLKDHTFT
                     ITGFVDSAEILSQRDMGYAGSGSGTLTAYGVILPSQFDQKVYNIARLKYQDLAGLNAFS
                     VAYEEKSKQHQEDLEQTLSDNGKARLQLLKKEGQESLDKGKETLDQAQANLQEGKRRLA
                     TAQARLQAQESQLSLLPQVQREQAIAQLTQAKQELSKEEDKLKQAEQNLAQEKEKLEKH
                     QQVLDELAEPKYQVYNRQTMPGGQGYLMYSNASASIRAVGNIFPVVLYAVAAMVTFTTM
                     TRFVDEERTHAGIFKALGYRSKDIIAKFLLYGLVAGTVGTALGSILGHYLLASVISSVI
                     TKGMVVGETQIQFYWTYSILALGLSWLASVLPAYLVARRELHDEAAQLLLPKPPVKGAK
                     ILLERIGFIWRRLNFTHKVTARNIFRYKQRMLMTIFGVAGSVALLFAGLGIQSSVAGVP
                     SRQFQQIQQYQMIVSENPSATNQDKAELEEVLKGQDIQTYQKIYSKTLDKDFKGKAGLQ
                     TITLMMTDKEDLTPFIHLQNHQQELTLKDGVVITTKLAQLAGVKVGQTFEIEGKELKVA
                     AITENYVGHFIYMSQASYEQLYGQLPQANTYLVSLRDTSATSIERQAGLLMNQAAVSSV
                     VQNASAIRLFDSVASSLNQTMTILVIVSVLLAIVILYNLTNINVAERIRELSTIKVLGF
                     HNNEVTLYIYRETIVLSLVGIVLGLVSGFYLHQFLIQMISPATILFYPQVGWEVYVISV
                     AAVSIILTLLGFFVNHHLRKVDMLEALKSVE"
     PFAM_domain     complement(14143..14394)
                     /aSDomain="FtsX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02687.23"
                     /description="FtsX-like permease family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1539_0093"
                     /evalue="6.20E-09"
                     /label="ctg1_1539"
                     /locus_tag="ctg1_1539"
                     /protein_end="885"
                     /protein_start="801"
                     /score="36.3"
                     /tool="antismash"
                     /translation="RELSTIKVLGFHNNEVTLYIYRETIVLSLVGIVLGLVSGFYLHQF
                     LIQMISPATILFYPQVGWEVYVISVAAVSIILTLLGFFV"
     PFAM_domain     complement(15310..15573)
                     /aSDomain="FtsX"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02687.23"
                     /description="FtsX-like permease family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1539_0092"
                     /evalue="4.90E-09"
                     /label="ctg1_1539"
                     /locus_tag="ctg1_1539"
                     /protein_end="496"
                     /protein_start="408"
                     /score="36.6"
                     /tool="antismash"
                     /translation="HAGIFKALGYRSKDIIAKFLLYGLVAGTVGTALGSILGHYLLASV
                     ISSVITKGMVVGETQIQFYWTYSILALGLSWLASVLPAYLVAR"
     CDS             complement(16799..17500)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 193.1; E-value:
                     9.3e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1540"
                     /transl_table=11
                     /translation="MAYIEMKHCYKRYQVGDTEIVANRDVNFEIEKGELVIILGASGAG
                     KSTVLNLLGGMDTNDEGEIWIDGVNIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTAKE
                     NVELASEIVTDALDPEQVLTDVGLAHRLNNFPAQLSGGEQQRVSIARAVAKNPKLLLCD
                     EPTGALDYQTGKQVLKILQDMSRQKGATVIIVTHNSALAPIADRVIHMHDASVKDVVIN
                     QHPQDIDSLEY"
     PFAM_domain     complement(17003..17428)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1540_0094"
                     /evalue="4.20E-35"
                     /label="ctg1_1540"
                     /locus_tag="ctg1_1540"
                     /protein_end="166"
                     /protein_start="24"
                     /score="121.3"
                     /tool="antismash"
                     /translation="DVNFEIEKGELVIILGASGAGKSTVLNLLGGMDTNDEGEIWIDGV
                     NIADYSSHQRTNYRRNDVGFVFQFYNLVSNLTAKENVELASEIVTDALDPEQVLTDVGL
                     AHRLNNFPAQLSGGEQQRVSIARAVAKNPKLLLCDEPT"
     CDS             complement(17619..18311)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101:phosphoglycerate mutase (Score: 186.8; E-value:
                     5.2e-57)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1541"
                     /transl_table=11
                     /translation="MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKE
                     AGIEFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAAEQ
                     FGDEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERALPFW
                     EDKIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDEKLNV
                     VSEYYLGK"
     aSDomain        complement(17625..18305)
                     /aSDomain="TIGR01258"
                     /aSTool="tigrfam"
                     /description="pgm_1: phosphoglycerate mutase 1 family"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1541_0029"
                     /evalue="5.30E-107"
                     /identifier="TIGR01258"
                     /label="ctg1_1541"
                     /locus_tag="ctg1_1541"
                     /protein_end="229"
                     /protein_start="2"
                     /score="354.7"
                     /tool="antismash"
                     /translation="KLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAG
                     IEFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAAEQFG
                     DEQVHIWRRSYDVLPPNMDRDDEHSAHTDRRYASLDDSVIPDAENLKVTLERALPFWED
                     KIAPALKDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDEKLNVVS
                     EYYLG"
     PFAM_domain     complement(17652..17930)
                     /aSDomain="His_Phos_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00300.24"
                     /description="Histidine phosphatase superfamily (branch 1)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1541_0096"
                     /evalue="6.40E-06"
                     /label="ctg1_1541"
                     /locus_tag="ctg1_1541"
                     /protein_end="220"
                     /protein_start="127"
                     /score="26.1"
                     /tool="antismash"
                     /translation="DEHSAHTDRRYASLDDSVIPDAENLKVTLERALPFWEDKIAPALK
                     DGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFEFDEKL"
     PFAM_domain     complement(17925..18302)
                     /aSDomain="His_Phos_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00300.24"
                     /description="Histidine phosphatase superfamily (branch 1)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1541_0095"
                     /evalue="1.20E-28"
                     /label="ctg1_1541"
                     /locus_tag="ctg1_1541"
                     /protein_end="129"
                     /protein_start="3"
                     /score="100.2"
                     /tool="antismash"
                     /translation="LVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGI
                     EFDQAYTSVLKRAIKTTNLALEASDQLWVPVEKSWRLNERHYGGLTGKNKAEAAEQFGD
                     EQVHIWRRSYDVLPPNMDRDDE"
ORIGIN
        1 atgaaaatca aagagcaaac taggaaacta gccgcaggtt gctcaaagca ccgctttgag
       61 gttgtaaata gaactgacga agtcagctca aaacactgtt ttgaggttgt ggatagaact
      121 gacgaagtca gctcaaaaca ccgttttgag gttgcagata gaactgacga agtcagtaac
      181 catatatacg gcaaggcgac gttgacgcgg tttgaagaga ttttcgaaga gtataaaaat
      241 cctcaagata ctttctttta tccgttagtt tataaggaga acacctatga aaaaaactgc
      301 tatttctatc tttgctctcc tagtattagg agctagttgc ctgttcctat tcagccagca
      361 aagctataaa aaaacagtcg ttcaatacta tgctaaggat cagaacctgc ccaataggat
      421 aacttatagt gaatatagcg acaaacgaga agccaactac ggtggcactc taaacatcac
      481 atctatcaaa caagctaatg acggagttta tgcaacctat ggagggcaat tgacaccttt
      541 ccaatattga taaattgata accagcctgt cttcatctag tcatgctggt ttttaagttc
      601 attctaaatc cttacctatt tcccccaact atgctatact taatttagta cattctttga
      661 gattggagct aatatgaaaa ttcataaaac tgtgaatcct gttgcctatg aaaacaccta
      721 ttacctagaa ggcgaaaagc accttatcgt agtagatcct ggtagtcatt gggaagccat
      781 tcgtcagaca atcgagaacc tcaacaaacc gatctgcgct attctcctga cccacgctca
      841 ttatgaccat atcatgagtc tggacttggt gcgcgagacc tttggcaatc ctcctgtcta
      901 tatcgcagag agcgaagcca gctggctcta cactcctgtc gataatctct ccggtctccc
      961 tcgccacgat gatatggcag atgtggtcac aaaacctgca gaacacacct ttgtctttca
     1021 cgaagaatac caactagagg aatttcgttt taaggttcta ccgaccccag ggcactctat
     1081 cggtggtgtt tccctagtct ttcctgatgc tcacctagtc ttgacgggag atgctctgtt
     1141 ccgcgaaaca attggacgga cggatcttcc gactggtagt acagagcaac tccttcatag
     1201 tatccagacc caactcttca ccctaccaaa ctacgatgtc tatccaggac atggtccagc
     1261 tactactatc gctcacgaaa aggccttcaa tccctttttc tagcaagatg atgacaatcg
     1321 atagcacaat ttaatactca atgaaaatca aagagcaaac taggaaacta gccgcaggtt
     1381 gctcaaagca cagctttgag gttgcagata aaactgacga agtcagctca aaacactgtt
     1441 ttgaggttgt ggatagaact gacgaagtca gctcaaaaca ccgttttgag gttgcagata
     1501 gaactgacga agtcagtaac atatatctac ggcaaggcga agctgacgtg gtttgaagag
     1561 attttcgaag agtattagaa ttataaaaaa cgcataatat cagatgtaga aaagtttgat
     1621 actatgcgtt ttatcatgaa aagattttct aaatcatctc ctcaaattga ttttttcaca
     1681 gtctaaaata tttgatagat aaactatgaa ttggagttat tctgactcct tacgaaagct
     1741 aaataatcca gcagttagag ttaacattcc aaatagggtg gcgagaattg agtgattttc
     1801 tccagtattt ggcaaagtct tagctacttg tttcgaaata gtttcagtct tagttgctaa
     1861 cgactcagct tgagtttttg tactacttgc gtcatttcct ttttgttcag tattactact
     1921 atttacaact ggaacaggag ttgtactacc tccgttatca cggcttgcgg caactttgaa
     1981 ggtcatagca tagatactga agtgattggt ttcaaaagta accttatctg tatcttgttt
     2041 gaacttcaat gcctgtaaag taccatctgg agcaacatag taaacatttt caactggctt
     2101 atcagcagaa agacttacta gaaccatgcc atttggctgg atagctttac cattcgcgtc
     2161 atatagatga atgtcaaatg ccttgtagtc ttttgattca agtgaagtcg gcttggtttc
     2221 ttctaccttg atatagctga catttttgag tgttgcttct gaaccatgca cttgaacgct
     2281 tccagctttg ttcgaaagaa cacgagtatt gtttgggatg gctggattaa gcgtaggcgt
     2341 tacgggagtt atcggtgtta ttggagcaac tggattcaca ggttgttcag ttggtttctc
     2401 tggcttagca ggttgtggtt gatctggaac agctggtgca actggttttg gtgtgtcagg
     2461 aactacaggt ttctcgattg gcttttctgc tggtttctct ggcttagcag gttgtggttg
     2521 atcagctgga acagtaggaa cacttggctg cttgtctggc ttaggttgtt cacttggctt
     2581 aacttcaggt tttacttgct cagctggttt ttcagcaggg ttcttaaaca agaaaacgta
     2641 agtatcgtag gtttcaccaa atagattgta tgaatgagtt ttagttttct catcatagcg
     2701 atttgtttct tcacttggga atcctggata atagagttct tccagttttc tatccttagt
     2761 taatgtataa acctgaatat cttctttctt ctcttttgat ttgatagtta aagagatgcc
     2821 accaccttgg agagttcgat ttgttccgta agttggattt ccatttttat taggaacttc
     2881 atagaaaatt gtataagctt cgtagttcat tccttccaac tctggaactt ttactcgaac
     2941 aagagcaggt ttaaacctac tgtccatatc tccaaatccg ctacctttaa attttatctc
     3001 tttaccgttt tcgaacatcg gattattgaa attcgaatta aaagtattta cttttatatg
     3061 agagcctgca tgaagcaggt ctggttcagc tgtccaccaa ccgtaagatg ttttttctac
     3121 attttcagta ggaaggggag cagcaaggtc gtttgttgtt agagtaggac gacctgttcc
     3181 attattaaac caacgttttg gctggtcgtt gcgataagga accttttgta atccagcatt
     3241 ttcagctggc ttcactggtt tagcaggttg tggttgctct gcaggtttaa cctctgtttg
     3301 agggttttct gctggttttg tagccggaac gggtgtttca gcaggtttat tttcaaccgg
     3361 cttgttctca gctggtttcg gctgcacagt tggttcaact gtctccgctg gtttcgaaat
     3421 ttcagcaggt ttttccgttt ccgctggttg cggatctttc ggtttttctt ctactggttt
     3481 atttttagtg taaataaaat agtagcggaa aagattatct cctttaccat ttttgtaacc
     3541 agaaccacgc aaagcatagg ctgcatcata actaactctg acaacctttg gatctggatc
     3601 aatatctgga tgatctgcag cggcttttac aacgtggcta aaagtgtagt cggagaattt
     3661 ttttgctgtt agtattccat ctgcgctatc tttgtcatgt acgttccatg tagagctaac
     3721 ttctgcttgt tttggactat caattcttga ttcagtagtg tatccatgtt tttggacaag
     3781 atcagcatct aagaaatctg cttggatttc atattttcga acgcttatat ctgagaatgc
     3841 tggcacggct ccaggttttt ctgggattag tctatggatc agttcatcaa tatcaactcc
     3901 gtcagcagcc caaagcttct cattagcctc agctatcagt ttattgtact cttcttgagt
     3961 cttagctgct cctttcttat aggctaaatc ctctgctacc atcttcttca tctcttcaga
     4021 atctgttata ggttgttctg gttcaggcgt tatgattggc aggcctggct caggtagctg
     4081 attggttgga tcgacgttgt attttttctc gatctcagca tttttcttgt cctctgcgat
     4141 agcctcatct gttccgtttg cgagaatgtt gccctcggtc gaaggttttt cgacaggcgc
     4201 gggctcttct accggctttt cagcaggttt cgaaaattct ttgcctggct ttggcttagc
     4261 gattgggtcg agcatactga aatcaaccca gctaccatta ggttttggtg caggtgttgg
     4321 ttgagcaaca ttaggtttag cagcaacatt tggctgcggc gcaacgtttt cctcggcacg
     4381 caccaaagtt ggcacggcag cactaagagt tacagcagag aaagtgacaa tacctagttt
     4441 agttagttta ttcataattt ttcctccttg ggaatatata attgcctttt taggcttata
     4501 aaataacaaa atcaacttcc tttcaagacc acaaaagcaa aattttgagc caactcattc
     4561 tctaaacatt taatgttctt gatagaagcc ttaaatgaac ctttatccat taactgaaca
     4621 atacagctat tacactatta catatcttaa taatttttaa attttttgtt accataagct
     4681 cgctaactac tttagagata gggaactaag tgtatcgcgt aacgaccgtt aaacgataca
     4741 caaaaaatac cagtctaata caggttaaaa acactgttaa actcgtattt tttaaatatt
     4801 catattgttg ttttgactgt ttcatcaaac ggtcgttaat cgaaacaaat ttacagcttc
     4861 attctaccat ttttccctat ttttagcaat gattttccgt ttttttgacg attgttcgcc
     4921 actttattgc gttctaacac tttatatagg gttgatgtag aaatttgttc agcttttgca
     4981 atattacgta tgcttatatt tgaatgtaga tatttgttaa gtatccgctc ctccttttct
     5041 tttgaaatcc gttttgctcc taatctaaca ccattttcct tagcttttcg aagtccttct
     5101 tttgtgcgaa acctcagatt ttccagctca ttttctgcca caaagcctaa aatgacgcaa
     5161 agtaacctgc caataagaaa gtctgtttct agtttttcat gcaaactgac tagctgaata
     5221 tgatattcat taaattgttc aataagttct agtagcttaa acatagatcg agtcagtcta
     5281 tctaacttat agatagtgaa agtaacctgc ttgccatctt tcgaaaagtc agaggccagt
     5341 tttaaggctt ttgtaagttc aggacgagtg ttatttgcac cagattcctt ttctataaaa
     5401 agtttatcgc aatgtttgag agcttcgatt tgcactttca atcctaggtc ttgcttatga
     5461 gtagatacac gggcgtagcc tatgttgata gtcttttgag acataaaaat cctcctgtta
     5521 tcttgatacg gagggatatt ttactatgaa ttttaaaata agaaaagact tcaatttcat
     5581 aatccctatg aactacaccc caaaagctag attattctat ctaacttttt agggtgtaca
     5641 tagataggga aggtgtaatt ataggagttt tacttgtctc tttgtattac caaataatca
     5701 cgcgctcttc tggtgaacgc cacattctgt caccttcttt gacatcatag gttgtaaaga
     5761 aatcatcgaa gtttggcact tgtacattga cacgaagttt ggctggcgcg tgcacatcga
     5821 cactagccaa aagtttcata aattctggac gacctttcat gcgccagatg cgaccgaagt
     5881 tgtagaagaa ctcttctgct gagaagtctg cttctctctt agctgcttca agcgctgctg
     5941 cgattcctcc caagtcagcc acgttttctg atacagtcaa tttaccgtta atggttgctc
     6001 cataagaatc ctgtccatca aactggtcaa tgactttttg tgttttctcc ttgaaggcag
     6061 catagtcgct ctctgtccac caatccttga ggctaccatt ttcatcaaag gaagctccat
     6121 tggtatcaaa ggcgtgagaa atttcatggg caataactgc cccaatacca ccgtagttag
     6181 cagaagatga ctgatgcaag tcatagaaag gtgcttgtaa aatagccgca ggaaagacaa
     6241 tcaggttctt ctgtggattg tagtaggcat tgaccatatg agcaggcatg ccccattctt
     6301 tgtagtctac aggttggttc cacttgctcc aactgtgctt gatttccaca cgcgcaaagg
     6361 ctagagcatt ctcaaaaaga ctggcagttt cattcaccac cttatccttg taacgtgcag
     6421 gcaattcttc tggatagcca atataaggtt tgatcacatt gagcttcacg atagcctgtt
     6481 tacaggtttc tggagtgagc cagtcattct taagcagacg ctccttatag acatcaatca
     6541 tggttgccac ttttttctcc acatccgcct tggcttctgg agagaacttc tcacgggcgt
     6601 accaaagacc cagggcttgc ttgaaaggtt cctgtgctag atgataagct gctttgacct
     6661 tatcttttgc ctctggaact ccagaaaggg cacggctgta ggcacctgac aagacacgga
     6721 tttcttctgt taaatagctg gttgaaagat tgactacact taaaattaag tttgctttga
     6781 gaagaggcca agcctcttca ctatagaatt gatctgctgc ttgccagaaa cgttcctcgt
     6841 ctacaataac cttgtctggt acttgtccaa gaacagcttg gaagaagtca ttcaaaggta
     6901 gggcaggcgc gaatttcttg aaatcttcgt aagaatatgg atggtaaagc ttggcatatt
     6961 ctgaaccttc ttcattagag agcaccactg ccgcaactcg gcggtccaat tcaagtcttt
     7021 tttctagcaa gtcttcaatt tcttcatcag agaaatcata agccttgagg agatttgcgc
     7081 tgctttcttt ccaaagagtc aagagctctt cgcgctgagg atgctcttct gcatagtagg
     7141 tcgtatctgg caagattgtg cttggagcgc tagcccatag aacattgatt ctagcatcca
     7201 taaagtctgg cgatacacca aaaggaagga agtttggttt tcctgcaagc tcaaactctg
     7261 ctagtttagc tgtaaaatcc gcaaaagtct ccaattcttg gaattcttta aggagtggta
     7321 agacaggtgt gataccgtca gcttctctct tgtcaaaatc acgaactagg cggtggtatt
     7381 tgacaaagtt tgccaagata gcatcctcag gcacctcttc acctgctaac cacttgtctg
     7441 ttgtcgccag catcaagtct tcaatttcct ggtctaaatc aacaaaacct cctgtttgag
     7501 acttatctgc tgggatttca gctgtctgtt gccattctcc attgatagca tcataaaaat
     7561 catcttgata acgtgtcatc ttgttctcgc tttcatttgt atttgtcttt atcttaacaa
     7621 aaatcactag ggaatgcaat taaaaatgaa ctttcctttt ctatcatttt tcagttagta
     7681 tttcaatttt ttaaaaattt tttaaaaatt cacaaaaaaa ttaattgtct gaaaaatgaa
     7741 ttgacaaaaa atatataaaa tgataaaatt ctatctatct catagctttg ctacttgaaa
     7801 tttaaatatt aggaggtaga ttttatgctt aagcaaaaac gtgttcattc tgtaagtatt
     7861 gcaggaatcg cagtagaagg atagtaatac tttcttcacc gaggctggta actagacttt
     7921 ctctagttac cttttctttt aattgatata aggagatata atggatctac taaaagctcg
     7981 tccaaaacta aaaaaggctt acccagtagt atataaagac ggatcggtct atataggtgg
     8041 gtttggagaa attacagaat atgaagaccc tagcggagct attgaataca tgctcaaaaa
     8101 aatggatgga attaataccg tcgaaaaaat cataagagaa gtttcagaaa cctacagtga
     8161 actatcacca tctgatgtaa tggaagctat tgatgaaatc agtaaagaac gatttatcga
     8221 ggatttaaat cttactggtt ctaaaatatt atccaagtat gaattagaac gttatcacag
     8281 aaacatcaac tttttttcat cttacgcaac tttaagtgaa aataaatata tttctcaaaa
     8341 aaaattaatt gattcaaaaa ttggaattat tggattaggc ggattaggct ctcacattat
     8401 atatgactta gctggcttag gtataggaga aataaaagct gttgaatttg atgtcgttga
     8461 tatatctaat ttaaatagac aaattttata taactttgat gatataggaa agagtaaagc
     8521 aagtatagca aaacaacgca tctatgaatt taatcctcaa ataaaattta ctgttgagga
     8581 aaagaaaatc aattcatctg aagatgttgt tgaatcattc cgaggattcg actgcttaat
     8641 actagttgcg gatagaccta aaatcaaact agcaagatgg gtaaatgaag ctatagtaaa
     8701 gctgaatatt cctttatttt gtgcaggttt agaagcgcaa cgagccctgc aatatactat
     8761 tatccccaaa atatctggat gcatagattg ttggagaaat actatccaaa aagaacaccc
     8821 tatttctcac ctaatccttg aagaaagaac tcgtttaaat ttagttggtg acaatactgc
     8881 catagctcct ctagtatctg tagcaactgg tatcatttgt tcagaagtta caaaatatat
     8941 cactggtatc ggtgaattaa ctactgtagg ccaattaaaa tctatagata tgaatacaat
     9001 gactacaaaa atagccgagc attggcatat agatcccaat tgtataacct gtcgtggagg
     9061 taatattatt gaatagaaat tacaaaatat tgtggctaac atttcttgta tccaactttg
     9121 gtgattggct aagaaaatta gctctacctt tgctagtatt tgagaaaaca ggatctccat
     9181 ttcatatggc tactctatac ggtatttcat ttttaccatg gattttattt tctctagtag
     9241 gaggtatatt agcagataaa ttcaaaaaag tatatatcat ttcgatatgt catttaatct
     9301 cattagtcat tctaagtttg ctaataatat cttttaaaaa tgataatata ctcttactct
     9361 taatttatat tttaaccttc ctgctctcct ctacagagcc attagtccac ccagcatttc
     9421 aaagcttgtt accacagatt gtaacagaca atcagctatc aaaagccaat tcaggaatcc
     9481 aacttattga caatacatta aatcttattg gtcctatgat tagtggttct gttctattac
     9541 ttattaatcc agctaaagtt ttatgggtca atgctcttac ctttttaatt gccagcctat
     9601 taattctctg cataaaaact ccagaaaata cactagtaaa tatctctaaa aaagagagtc
     9661 tttctaaaac aatatctatt ggtttgcact atgtaaaaaa tgataaaatc atcctaagtg
     9721 gagctattct tttttttgga acaaactttg gtattcatat atttcaggcc aacttagttt
     9781 actatattac agatgttcta ggctatacct cctttcacta tggattaata ctctcaatag
     9841 ctggtgtagg agctatatta ggtgctattc ttgcccctga attaattaaa aagtttagat
     9901 atggaaaaat cctctccatc agtacaatgc tagctggtct atctactatg ttgctatcaa
     9961 ttaacacaaa ctatatatat atgggagtat ttttaggttt gagtaatatg tttggcaata
    10021 tcaatgccat tacatatttt acgttacgac aaaaagttgt caaaaaagaa atgttgggac
    10081 gtgttgttag tattactaga atgatctcat ttgcttctat ccccttagga gcataccttg
    10141 gagggatact tgtttcacat aacttaacta tcataagtat tctaatatta gcaggtacta
    10201 taagatttct tgcaggggga tttagttact ttagtccatt aaccaaaagt aaaaactatt
    10261 gatgtttaaa gtgtgatata cttattcaaa ataattcatc aaagaatcgc tcatactcaa
    10321 caaaaatcaa agggtaaact aaggggttat ccatggatag attaaaacac tttttgaagt
    10381 acagatagta aatctaatta aagaatcttt aaaatcataa aaacgcataa tatcaggtgt
    10441 ataaaccttg agattatgcg ttttattaga cctcctacta aatatatagc aaaatagagt
    10501 tagttggagc tggagtagta caatgctgct tctaaggcat ttttataatt tactttgaat
    10561 ttctaacaat gttttaaaaa actcggtgga ctattccaga ttcaatccac tatatattga
    10621 ttcccttgtg tgatgtgtaa agatttttta atgacttatt ttaatttttt caaaaattaa
    10681 cttgacttaa ttttttttta atgtatatta agagacagga ggaatataag tttatgatac
    10741 gtatcgaaaa cctcagtgtc tcctacaaag aaacgttggc acttaaggat atttcactag
    10801 tgctccatgg accaacaatt accggcatca ttggtccaaa cggcgctggg aaatcaacac
    10861 tattaaaagg tatgctggga attatcccac atcaaggtca ggcatttctc gatgacaagg
    10921 aagttaaaaa atccttacac cgaattgcct atgtcgaaca aaaaatcaat atcgactaca
    10981 actttcccat caaggtcaag gaatgcgtct cgttaggact ctttccctct atccctctct
    11041 ttcgaagttt aaaggctaaa cattggaaga aagtgaaaga agcccttgaa atcgtcggtc
    11101 tagctgacta cgctgaacgg caaatcagtc aactgtctgg aggtcaattc cagcgggtct
    11161 tgattgccag atgtttggtg caggaagccg actatatcct cttggatgaa ccctttgttg
    11221 ggattgactc tgtcagtgag gaaatcatca tgaatacgct gagagatctg aaaaaagctg
    11281 ggaagacggt tctcatcgtc caccacgacc tcagcaaggt tccccactac ttcgatcaag
    11341 tcttgcttgt caatcgagaa gtgattgcct ttggtccaac caaagaaacc tttaccgaaa
    11401 ccaatctcaa agaagcttac ggtaatcgac tctttttcaa tggaggtgac ctatgattgc
    11461 agaatttatc gatggattgc aaaaattcca tttcctacaa aatgccttga taacagctat
    11521 tgtcgtcggg gtcgtagctg gagctgtggg atgtttcatc attctacgcg ggatgtcact
    11581 catgggagat gccatttcac atgctgtctt accaggtgta gccctctcct tcatcttggg
    11641 ccttgacttc tttatcggag ccattgtctt tggattgcta gctgccatca tcattaccta
    11701 catcaaggga aactcgatta tcaaaagcga taccgccatc ggcattacct tttcttcttt
    11761 cttagccctc ggtatcatct tgattagtgt cgctaaaagt tcaactgacc ttttccatat
    11821 cctttttggt aatatcctag ccgtccaaga tacggatatg cttattacta tgggtgttgg
    11881 tgcagccatt ctcttgttaa tctggatttt cttcaagcaa ctcttgataa cttcctttga
    11941 tgaactcttg gctaaagcca tgggaatgcc tgtcaatttc tatcactacc ttctcatggt
    12001 actcttgact ctcgtgtctg tgacagccat gcaaagtgtc ggaactatcc tgattgtagc
    12061 catgctgatt accccagccg cgactgctta tctgtatgct aatagtctga aaagtatgat
    12121 tttcctatct tcaacctttg gagcgacagc ttcagttttg gggctcttta tcggctatag
    12181 ctttaacgtt gcggcaggtt ctagtatcgt gcttacagcc gctagtttct ttctcattag
    12241 cttctttatc gctccaaaac aacgatattt gaaactaaaa aataaacatt tgttaaaata
    12301 aggggcaaag ccccaataat aaattggagg atctaatgaa aaaattaggt acattactcg
    12361 ttctctttct ttccgtcatt gctcttgtag catgtgctag cggaaaaaaa gatacagctt
    12421 ctggtcaaaa actaaaagtt gttgctacaa actcaatcat tgctgatatt actaaaaata
    12481 ttgctggtga caagattgat cttcacagta tcgttccgat tgggcaagac ccacacgaat
    12541 acgaaccact tcctgaagat gttaagaaaa cttctgaggc agacctcatt ttctataacg
    12601 gtatcaacct tgaaacaggt ggcaatgctt ggtttacaaa attggtagaa aatgctaaga
    12661 aaactgaaaa caaagactac tttgcagtca gcgaaggcgt tgatgtcatc taccttgaag
    12721 gaaaaaatga aaaaggtaaa gaagacccac acgcttggct caaccttgaa aatgggatta
    12781 tctttgctaa aaatatcgcc aaacaattga gtgctaaaga tcctaacaac aaggaattct
    12841 atgaaaaaaa tctcaaagaa tatactgata agttagacaa acttgataaa gaaagtaagg
    12901 ataaatttac taagatccct gctgaaaaga aactcattgt aaccagcgaa ggagcattca
    12961 aatacttctc taaagcctat ggtgtcccaa gtgcttacat ctgggaaatc aatactgaag
    13021 aagaaggaac acctgaacaa atcaagacct tggttgaaaa acttcgccaa acaaaagttc
    13081 catcactctt tgtagaatca agtgtggatg accgtccaat gaagactgtt tcacaagaca
    13141 caaacatccc aatctacgca caaatcttta ctgactctat cgcagaacaa ggtaaagaag
    13201 gtgacagcta ctacagcatg atgaaataca accttgataa aattgctgaa ggattggcaa
    13261 aataatcctc tgaaaaacgt cattctcaca tgagctgacg ttttttctat gcacacattt
    13321 ccggtcaaat cattggaaaa ttctgaccgt ttcagctaca atggaagaaa aaagattgga
    13381 gtatcttatg gtaacttttc tcggaaatcc tgtgagcttt acaggtaaac aactacaagt
    13441 cggcgacaag gcgcttgatt tttctctcac tacaacagac ctttctaaaa aatctctggc
    13501 tgattttgat ggcaagaaaa aagtcttgag tgtcgtgcct tctatcgata caggcatctg
    13561 ctcaactcaa acgcgtcgct ttaatgaaga actggctgga ctggacaaca cggtcgtctt
    13621 gactgtttcc atggacctgc cttttgccca aaaacgttgg tgcggtgctg aaggtattga
    13681 aaatgccatc atgctctcag actactttga ccattctttt ggacgtgatt acgctctctt
    13741 aatcaatgag tggcacctat tggcacgcgc ggtctttgtc cttgatactg acaatactat
    13801 tcgctatgtt gaatacgtgg acaatatcaa ctctgaacca aacttcgaag ccgcaattgc
    13861 agctgctaaa gccctataga aaaaatcctc tgtcacaaag agttccctac tctttgaaac
    13921 ggagaatttt tgtttacaag taaatacaag ttcaatcagc taaaaacaac caccttatac
    13981 tcttcgaaaa tctcttcaaa ccacgtcagc tttatctgca acctcaaagc ggtgctttga
    14041 gcaacctacg actagcttcc tagtttgctc tttgattttc attgagtatt actctacaga
    14101 tttcaaggct tctaacatat caacctttct caaatgatga ttaacaaaga aaccaagcaa
    14161 ggtcaaaatg atacttactg ctgccactga gattacatag acttcccagc ctacctgtgg
    14221 ataaaagaga atagtcgctg gtgaaatcat ttgaatcaaa aattggtgta aatagaaacc
    14281 agataccaga ccaaggacga ttccaacaag ggacagcaca atcgtctcac ggtaaatgta
    14341 gagagtgact tcattattat gaaaaccgag aaccttgata gtggagagtt cacggattct
    14401 ttcagctacg ttgatattgg tcaaattgta gaggataaca atagccaaca gaaccgacac
    14461 gatgaccaag atggtcatgg tctgattgag tgagctagcg acggagtcaa agaggcgaat
    14521 ggctgaagca ttttggacaa cactggacac cgcagcttga ttcataagta agcctgcctg
    14581 tctttcgata ctagtagcac tggtatctct taacgagacc aaataagtgt tggcttgggg
    14641 tagctgtccg taaagttgct catagctagc ctgactcata taaataaagt gaccaacgta
    14701 gttctcagta atggcagcaa cctttagttc cttaccttca atttcgaaag tctgcccaac
    14761 cttgacacct gccagctggg ctagtttagt tgtaataacg actccatctt tcaatgtcag
    14821 ctcctgctga tgattttgca gatggataaa gggagtcaaa tcttccttat ctgtcatcat
    14881 aagggtaata gtctgaagac cagccttacc tttgaaatcc ttatctagcg tttttgaata
    14941 gattttctga taggtttgaa tatcctgccc tttcaacact tcttccaact ctgccttgtc
    15001 ttgattggtc gcactaggat tttcagagac aatcatttga tactgttgga tttgttgaaa
    15061 ctgtctagac ggaactcctg ctacagagga ttggatgccc aagcctgcaa agagcagagc
    15121 gactgaacct gccacaccaa atattgtcat caacatccgc tgtttataac ggaagatatt
    15181 gcgggctgtt actttatggg taaaattgag acgacgccaa ataaaaccga tacgctccag
    15241 taagatttta gctcctttaa caggtggttt aggcagtaaa agctgagctg cttcatcgtg
    15301 aagttccctc cgagccacca gataggctgg taacacactc gccaaccaac tcaagccaag
    15361 agctagtatg ctataggtcc aatagaactg aatctgagtt tctcccacca ccataccttt
    15421 tgtaataaca cttgaaatca cactggctag caaataatgg ccaagtatac tacctagagc
    15481 tgttccgaca gtcccagcta ctagaccgta aaggagaaac ttggcaataa tatccttgct
    15541 acgataaccc aaggccttaa aaatccctgc atgtgttcgc tcttcatcca caaaacgggt
    15601 catagttgta aaggtcacca tagctgctac ggcataaagc actacaggaa agatattgcc
    15661 cactgcccga atactggctg aagcattact gtacatgagg tagccttgac cacctggcat
    15721 ggtctgacga ttatagactt gatacttggg ctcagctaat tcatccaaga cttgctgatg
    15781 tttttctaat ttttcctttt cttgggctag attttgttca gcctgcttta gtttgtcctc
    15841 ttccttgctc aattcctgct tggcttgggt aagttgagca atggcttgct ctctctgaac
    15901 ttgaggtagc aaagataatt gactttcctg agcctgtaaa cgagcttgag cagttgctaa
    15961 acgacgcttg ccttcctgca aattagcctg tgcctggtca agggtctctt tccccttatc
    16021 gagagactct tgcccttctt ttttcaagag ctgcagacgt gccttgccat tatctgataa
    16081 agtttgttca aggtcttcct gatgttgctt ggatttttct tcataagcta ctgaaaaggc
    16141 atttaagcct gctaaatctt gatatttcaa acgagctata ttgtagactt tctgatcaaa
    16201 ctgactaggt aaaatcaccc cgtaggctgt cagagtccca cttccacttc ctgcatagcc
    16261 catatctcgc tgagagagga tttcagccga atccacaaaa ccagtaatgg taaaagtatg
    16321 gtcttttaaa gaggaatgac tgccttcttt ttctttaaaa ctaatctcct gtcctacgct
    16381 atattgactc tgcagatgac tggccaaagc aatttcctgg tctgactgcg gaagtcgtcc
    16441 ctctctgagc tgaaaggttg aaattcgctc tggtttggag tacagccgaa tagcatcctg
    16501 cccattagcc atggtcacat ctgtcaagta gccaaactcg acctctgcgc cctctaactg
    16561 ttctagttct tcttgatctg cttgatccaa accatagtta gacatgactg ccaaatccaa
    16621 ggttttagca gttgtgaaat aagcattagc ggtcgcctcc atattggggc cagttacttt
    16681 gagacctact agggctagag agcccaacat catcagggtc aagatggata aaaaacgccc
    16741 cttggagcct gtgaaggact gaattaagtc cttccaatag gtttttcgct taatcatgct
    16801 agtactccaa actatctata tcctgaggat gctggttgat caccacatcc ttgacactgg
    16861 catcgtgcat atgaatcacg cgatcagcaa taggagctag cgcgctatta tgggtcacaa
    16921 taatcactgt tgcccctttt tgacgagaca tatcttggag aatcttcaag acttgcttgc
    16981 ccgtctgata atccaaggca cctgttggtt catcacaaag gagcagttta ggatttttag
    17041 ctaccgcgcg tgcaatggag actcgctgtt gctcccctcc agaaagctgg gctgggaaat
    17101 tatttagacg atgagccaga cctacatctg tcagcacctg ctcaggatcc aaggcatctg
    17161 tcacgatttc agaagccagt tccacatttt ccttagcagt cagattggaa actagattgt
    17221 aaaactgaaa aacaaaaccc acatcatttc tacgataatt ggtgcgctgg tgggaactat
    17281 agtctgcaat attgacacca tcaatccaga tttccccctc gtcattggta tccatgcctc
    17341 caagaaggtt aagaaccgtt gacttaccag cacctgacgc accaaggata atcaccagct
    17401 cccctttttc aatctcaaaa ttcacatcac gattggccac aatctccgtg tccccaacct
    17461 gatatcgctt gtaacaatgt ttcatctcaa tataagccat cagacccacc ctctctcaaa
    17521 caaattactt cctactacca ttataacgct ttttcaacta gttggaaact gggaacaaaa
    17581 acaaaaagcc tagaaatcaa ttctagactt acattttttt attttccaag gtagtattca
    17641 gaaactacgt tcaatttttc gtcgaattcg aataccaatg gtgggaagtt agggatttcc
    17701 acgtccatga tctcgtcatc tgacaaacct ttgatatgtt ttacaagggc acggattgag
    17761 ttaccgtgag ctcctacgaa tacgttttta ccatctttaa gagctggagc gattttatct
    17821 tcccagaatg gaagggcacg ttccaaagtc actttcaagt tttcagcatc tgggattact
    17881 gaatcgtcaa gtgaagcata acgacggtct gtgtgagctg agtgctcatc atcacggtcc
    17941 atgtttggag gcaatacatc gtatgaacga cgccagatgt gaacttgctc atcaccaaat
    18001 tgttcagcag cttcagcttt gtttttacca gtcaaaccac cgtagtgacg ttcgttcaag
    18061 cgccatgatt tttcaactgg aacccacaat tgatcagaag cttcaagagc caaatttgtt
    18121 gttttgatag ctcgtttcaa tactgaagtg taagcttggt caaattcgat accagcttct
    18181 ttgatcaatt taccagcgtc aatcgcttgt tgcgtacctt tttcagacaa atcaacatca
    18241 gcccaaccag tgaaaaggtt agctttgttc cattcagact caccgtggcg agcaaaaacc
    18301 aattttacca t
//
