GCF_016127455.1_ASM1612745v1_genomic - 7 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP066013.1

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	RiPP-like	53,797	64,051
Region 1.2	T3PKS	66,069	107,238	capsular polysaccharide	Saccharide:Exopolysaccharide	3%
Region 1.3	siderophore	439,875	452,671	staphyloferrin A	Other:Non-NRP siderophore	75%
Region 1.4	cyclic-lactone-autoinducer	581,692	602,401	kijanimicin	Polyketide	4%
Region 1.5	terpene	855,823	876,300	heme D1	Other	11%
Region 1.6	NRPS	2,181,851	2,229,299	rhizocticin A	Other	6%
Region 1.7	terpene,siderophore	2,449,908	2,482,515	staphylobactin	Other	75%

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	RiPP-like	53,797	64,051
Region 1.2	T3PKS	66,069	107,238	capsular polysaccharide	Saccharide:Exopolysaccharide	3%
Region 1.3	siderophore	439,875	452,671	staphyloferrin A	Other:Non-NRP siderophore	75%
Region 1.4	cyclic-lactone-autoinducer	581,692	602,401	kijanimicin	Polyketide	4%
Region 1.5	terpene	855,823	876,300	heme D1	Other	11%
Region 1.6	NRPS	2,181,851	2,229,299	rhizocticin A	Other	6%
Region 1.7	terpene,siderophore	2,449,908	2,482,515	staphylobactin	Other	75%

No secondary metabolite regions were found in these records:: NZ_CP066012.1

Compact view

NZ_CP066013.1 - Region 1 - RiPP-like

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Location: 53,797 - 64,051 nt. (total: 10,255 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.1	0.21	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.18	Other	bacilysin	Bacillus velezensis FZB42
BGC0000787.1	0.16	Saccharide	O-antigen	Escherichia coli
BGC0001743.1	0.16	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0000504.1	0.16	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.16	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000484.1	0.15	RiPP	glycocin F	Lactobacillus plantarum
BGC0000554.1	0.15	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001120.1	0.15	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000548.1	0.15	RiPP	salivaricin A	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.1	0.54	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.50	Other	bacilysin	Bacillus velezensis FZB42
BGC0000787.1	0.47	Saccharide	O-antigen	Escherichia coli
BGC0001743.1	0.46	RiPP	plantaricyclin	Lactobacillus plantarum
BGC0000504.1	0.46	RiPP	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.1	0.46	RiPP	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000484.1	0.46	RiPP	glycocin F	Lactobacillus plantarum
BGC0000554.1	0.46	RiPP	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001120.1	0.45	NRP, Polyketide	burkholderic acid	Burkholderia thailandensis E264
BGC0000548.1	0.45	RiPP	salivaricin A	Streptococcus salivarius

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No matches found.

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NZ_CP066013.1 - Region 2 - T3PKS

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Location: 66,069 - 107,238 nt. (total: 41,170 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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Pfam domains

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000286.1	0.23	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000679.1	0.17	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0000867.1	0.17	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000255.1	0.17	Polyketide	pederin	Uncultured bacterium
BGC0000866.1	0.17	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001104.1	0.16	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001739.1	0.16	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000205.1	0.16	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000934.1	0.16	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000922.1	0.16	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000286.1	0.56	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000679.1	0.48	Terpene	diazepinomicin	Micromonospora sp. M42
BGC0000867.1	0.48	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000255.1	0.48	Polyketide	pederin	Uncultured bacterium
BGC0000866.1	0.48	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001104.1	0.47	NRP, Polyketide	myxovirescin A1	Myxococcus xanthus DK 1622
BGC0001739.1	0.46	Other	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0000205.1	0.46	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000934.1	0.46	Other (Phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000922.1	0.46	Other	pseudomonas quinolone signal (PQS)	Pseudomonas aeruginosa PAO1

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Detailed TIGRFAM domain annotation

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NZ_CP066013.1 - Region 3 - siderophore

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Location: 439,875 - 452,671 nt. (total: 12,797 nt) Show pHMM detection rules used

siderophore: IucA_IucC

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.33	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000939.1	0.30	Other	aerobactin	Grimontia hollisae
BGC0001870.1	0.30	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.1	0.18	Other	vibrioferrin	Vibrio alginolyticus
BGC0000883.1	0.15	Other	arginomycin	Streptomyces arginensis
BGC0000943.1	0.15	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001767.1	0.10	NRP	salinichelins	Salinispora pacifica CNY331
BGC0001738.1	0.09	NRP, Polyketide	phomasetin	Pyrenochaetopsis sp.
BGC0000708.1	0.08	Saccharide	lividomycin	Streptomyces lividus
BGC0001211.1	0.08	NRP	albachelin	Amycolatopsis alba DSM 44262

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000944.1	0.67	Other (Non-NRP siderophore)	staphyloferrin A	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000939.1	0.64	Other	aerobactin	Grimontia hollisae
BGC0001870.1	0.64	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000947.1	0.49	Other	vibrioferrin	Vibrio alginolyticus
BGC0000883.1	0.46	Other	arginomycin	Streptomyces arginensis
BGC0000943.1	0.45	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0001767.1	0.35	NRP	salinichelins	Salinispora pacifica CNY331
BGC0001738.1	0.32	NRP, Polyketide	phomasetin	Pyrenochaetopsis sp.
BGC0000708.1	0.32	Saccharide	lividomycin	Streptomyces lividus
BGC0001211.1	0.32	NRP	albachelin	Amycolatopsis alba DSM 44262

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NZ_CP066013.1 - Region 4 - cyclic-lactone-autoinducer

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Location: 581,692 - 602,401 nt. (total: 20,710 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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Pfam domains

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.1	0.13	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000540.1	0.13	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000624.1	0.09	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001872.1	0.08	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001053.1	0.08	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0000082.1	0.06	Polyketide	kijanimicin	Actinomadura kijaniata
BGC0001056.1	0.05	NRP, Polyketide	zeamine, zeamine I, zeamine II, prezeamine, prezeamine I	Serratia plymuthica RVH1
BGC0001700.1	0.05	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0000163.1	0.03	Polyketide	tetronasin	Streptomyces longisporoflavus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001687.1	0.42	Other	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0000540.1	0.42	RiPP	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000624.1	0.33	RiPP	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0001872.1	0.31	Polyketide	fabclavine-polyamine	Xenorhabdus bovienii SS-2004
BGC0001053.1	0.30	NRP, Polyketide	tubulysin A	Archangium disciforme
BGC0000082.1	0.24	Polyketide	kijanimicin	Actinomadura kijaniata
BGC0001056.1	0.24	NRP, Polyketide	zeamine, zeamine I, zeamine II, prezeamine, prezeamine I	Serratia plymuthica RVH1
BGC0001700.1	0.22	Polyketide	niphimycins C-E	Streptomyces sp. IMB7-145
BGC0000163.1	0.17	Polyketide	tetronasin	Streptomyces longisporoflavus

Similar known gene clusters

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Detailed TIGRFAM domain annotation

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NZ_CP066013.1 - Region 5 - terpene

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Location: 855,823 - 876,300 nt. (total: 20,478 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Pfam domains

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Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.1	0.23	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.18	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0001685.1	0.18	Other	N-acyloxyacyl lysine	Raoultella ornithinolytica 10-5246
BGC0000698.1	0.14	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0000905.1	0.13	Other	heme D1	Heliobacillus mobilis
BGC0000906.1	0.13	Other	heme D1	Heliophilum fasciatum
BGC0001754.1	0.07	NRP, Polyketide	ralsolamycin	Ralstonia solanacearum GMI1000
BGC0001363.1	0.07	NRP, Polyketide	ralsolamycin	Ralstonia solanacearum GMI1000
BGC0000702.1	0.07	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001103.1	0.06	NRP, Polyketide	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000859.1	0.57	Other	ectoine	Methylomicrobium alcaliphilum
BGC0000854.1	0.50	Other	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0001685.1	0.49	Other	N-acyloxyacyl lysine	Raoultella ornithinolytica 10-5246
BGC0000698.1	0.43	Saccharide	hygromycin A	Streptomyces hygroscopicus
BGC0000905.1	0.41	Other	heme D1	Heliobacillus mobilis
BGC0000906.1	0.41	Other	heme D1	Heliophilum fasciatum
BGC0001754.1	0.30	NRP, Polyketide	ralsolamycin	Ralstonia solanacearum GMI1000
BGC0001363.1	0.30	NRP, Polyketide	ralsolamycin	Ralstonia solanacearum GMI1000
BGC0000702.1	0.27	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001103.1	0.27	NRP, Polyketide	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

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NZ_CP066013.1 - Region 6 - NRPS

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Location: 2,181,851 - 2,229,299 nt. (total: 47,449 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS domains

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NRPS/PKS modules

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457.1	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001686.1	0.30	NRP	N-octanoyl-Met-Phe-H	Clostridium sp. CAG:567
BGC0000410.1	0.30	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001538.1	0.29	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001444.1	0.29	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000888.1	0.27	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.27	Other	bacilysin	Bacillus velezensis FZB42
BGC0001873.1	0.25	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0000313.1	0.25	NRP	beauvericin	Beauveria bassiana
BGC0000342.1	0.25	NRP	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000457.1	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0001686.1	0.64	NRP	N-octanoyl-Met-Phe-H	Clostridium sp. CAG:567
BGC0000410.1	0.63	NRP	pseudomonine	Pseudomonas fluorescens
BGC0001538.1	0.63	NRP, Polyketide	caboxamycin	Streptomyces sp. NTK 937
BGC0001444.1	0.63	Other	caboxamycin	Streptomyces sp. NTK 937
BGC0000888.1	0.61	Other	bacilysin	Bacillus sp. CS93
BGC0001184.1	0.61	Other	bacilysin	Bacillus velezensis FZB42
BGC0001873.1	0.59	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0000313.1	0.59	NRP	beauvericin	Beauveria bassiana
BGC0000342.1	0.59	NRP	enniatin	Fusarium equiseti

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 6, location 2181850 - 2229299:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ser - ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg1_2094

Search NORINE for peptide: strict or relaxed

AMP-binding (449..852): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHlSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

AMP-binding (1487..1890): ser

NRPSPredictor2: ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: ser, thr, dhpg, hpg
Small clusters prediction:: ser
Single AA prediction:: ser

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHlSLVDK
Nearest Stachelhaus code:: ser
Stachelhaus code match:: 90% (moderate)

ctg1_2101

Search NORINE for peptide: strict or relaxed

AMP-binding (26..423): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: qkwcVAGLlK
Nearest Stachelhaus code:: pro
Stachelhaus code match:: 50% (weak)

NZ_CP066013.1 - Region 7 - siderophore,terpene

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Location: 2,449,908 - 2,482,515 nt. (total: 32,608 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)
siderophore: IucA_IucC

Legend:

core biosynthetic genes

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Gene details

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KnownClusterBlast

Pfam domains

TIGRFAM domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.1	0.59	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.1	0.36	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0001531.1	0.31	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.1	0.31	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001713.1	0.31	Other	ochrobactin	Ochrobactrum anthropi
BGC0000942.1	0.28	Other	petrobactin	Bacillus anthracis str. Ames
BGC0001587.1	0.28	Other	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000896.1	0.27	Other	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0001870.1	0.27	Other	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0000703.1	0.26	Saccharide	kanamycin	Streptomyces kanamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.1	0.73	Other	staphylobactin	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.1	0.69	Other	vibrioferrin	Vibrio parahaemolyticus
BGC0000939.1	0.66	Other	aerobactin	Grimontia hollisae
BGC0001531.1	0.65	Other	bisucaberin B	Tenacibaculum mesophilum
BGC0000295.1	0.64	NRP	acinetoferrin	Acinetobacter haemolyticus
BGC0001713.1	0.64	Other	ochrobactin	Ochrobactrum anthropi
BGC0000942.1	0.61	Other	petrobactin	Bacillus anthracis str. Ames
BGC0000633.1	0.57	Terpene	carotenoid	Streptomyces avermitilis
BGC0001456.1	0.56	Terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.1	0.56	Terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known gene clusters

Detailed Pfam domain annotation

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Detailed TIGRFAM domain annotation

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