LOCUS       NZ_CP045783.1          10624 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_CP045783.1 Klebsiella variicola strain LEMB11 chromosome,
            complete genome.
ACCESSION   NZ_CP045783
VERSION     NZ_CP045783.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:29:16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3015349
            Orig. end    :: 3025973
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10624
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[3020349:3020973](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5624
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10624
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10624
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(1919..2443)
                     /locus_tag="ctg1_2805"
                     /transl_table=11
                     /translation="MASADRGLPGGGAAHLVRATGRAGRVRIRSPGKRSATGETCRHAA
                     RSTETQKAHPSGWALHLFDAWQFPTLTWGDPTLPSALRRFTSEFGMGSGGTTALVPPGK
                     FFVLVLCLLHSYCVGCSRECQSHTYVCSFHRLVCRLVSAQNPSDSESELKILSQIRQNS
                     FGVVRLSLTVH"
     CDS             complement(2486..2992)
                     /locus_tag="ctg1_2806"
                     /transl_table=11
                     /translation="MTPLLAIAAWSGTGKTTLLKRLIPELCVRGLRPGLIKHTHHDMDV
                     DKPGKDSYELRKAGAAQTIVASEQRWALMTETPETPELDLTWLVSRMDASKLDLVLVEG
                     FKHEPVPKILLFRQNSGHRVEELIIDKHTIAVASDMPIATSLPQLDLNDIQQIATFIAN
                     WLERH"
     aSDomain        complement(2501..2980)
                     /aSDomain="TIGR00176"
                     /aSTool="tigrfam"
                     /description="mobB: molybdopterin-guanine dinucleotide
                     biosynthesis protein B"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2806_0015"
                     /evalue="3.50E-51"
                     /identifier="TIGR00176"
                     /label="ctg1_2806"
                     /locus_tag="ctg1_2806"
                     /protein_end="164"
                     /protein_start="4"
                     /score="171.2"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKRLIPELCVRGLRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTIVASEQRWALMTETPETPELDLTWLVSRMDASKLDLVLVEGFKHE
                     PVPKILLFRQNSGHRVEELIIDKHTIAVASDMPIATSLPQLDLNDIQQIATFIANW"
     PFAM_domain     complement(2576..2980)
                     /aSDomain="MobB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03205.16"
                     /description="Molybdopterin guanine dinucleotide synthesis
                     protein B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2806_0033"
                     /evalue="1.80E-48"
                     /label="ctg1_2806"
                     /locus_tag="ctg1_2806"
                     /protein_end="139"
                     /protein_start="4"
                     /score="163.9"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKRLIPELCVRGLRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTIVASEQRWALMTETPETPELDLTWLVSRMDASKLDLVLVEGFKHE
                     PVPKILLFRQNSGHRVEELIIDKHTIAVASD"
     CDS             complement(2989..3570)
                     /locus_tag="ctg1_2807"
                     /transl_table=11
                     /translation="MQSEAITGVVLAGGKATRMGGIDKGLQALNGRPLWRHVAETLAPQ
                     VDELVISANRHLEQWRASGYPVFRDIQEGYQGPLAGMLAVMQQVASTWFVFCPCDTPFI
                     PSFLVERFIQQRGAAPVVWAHDGERDHPAVALVHRQIIPELEAYLAHGERRVMVFMRQV
                     GGRPVNFSDVKSAFINVNTLEDLQQMQEPS"
     aSDomain        complement(3010..3555)
                     /aSDomain="TIGR02665"
                     /aSTool="tigrfam"
                     /description="molyb_mobA: molybdenum cofactor
                     guanylyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2807_0016"
                     /evalue="1.90E-68"
                     /identifier="TIGR02665"
                     /label="ctg1_2807"
                     /locus_tag="ctg1_2807"
                     /protein_end="187"
                     /protein_start="5"
                     /score="228.2"
                     /tool="antismash"
                     /translation="ITGVVLAGGKATRMGGIDKGLQALNGRPLWRHVAETLAPQVDELV
                     ISANRHLEQWRASGYPVFRDIQEGYQGPLAGMLAVMQQVASTWFVFCPCDTPFIPSFLV
                     ERFIQQRGAAPVVWAHDGERDHPAVALVHRQIIPELEAYLAHGERRVMVFMRQVGGRPV
                     NFSDVKSAFINVNTLEDLQ"
     PFAM_domain     complement(3097..3549)
                     /aSDomain="NTP_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12804.9"
                     /description="MobA-like NTP transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2807_0034"
                     /evalue="1.40E-35"
                     /label="ctg1_2807"
                     /locus_tag="ctg1_2807"
                     /protein_end="158"
                     /protein_start="7"
                     /score="123.0"
                     /tool="antismash"
                     /translation="GVVLAGGKATRMGGIDKGLQALNGRPLWRHVAETLAPQVDELVIS
                     ANRHLEQWRASGYPVFRDIQEGYQGPLAGMLAVMQQVASTWFVFCPCDTPFIPSFLVER
                     FIQQRGAAPVVWAHDGERDHPAVALVHRQIIPELEAYLAHGERRVMV"
     PFAM_domain     3642..3899
                     /aSDomain="DUF1040"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06288.15"
                     /description="Protein of unknown function (DUF1040)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2808_0035"
                     /evalue="4.00E-46"
                     /label="ctg1_2808"
                     /locus_tag="ctg1_2808"
                     /protein_end="86"
                     /protein_start="0"
                     /score="155.4"
                     /tool="antismash"
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAKEAGYDGELSDL
                     SDDILIYHLKMRDSSKDAVIPGIQKDYEEDFKTALLRARGV"
     CDS             3642..3911
                     /locus_tag="ctg1_2808"
                     /transl_table=11
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAKEAGYDGELSDL
                     SDDILIYHLKMRDSSKDAVIPGIQKDYEEDFKTALLRARGVIKE"
     CDS             3987..4973
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_2809"
                     /sec_met_domain="APH (E-value: 3.4e-44, bitscore: 149.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDKAFTFQTLRPDTIIDGLFDLGMRVDSGLTPLNSYENRVYQFQ
                     DEERHRYVVKFYRPERWSAEQILEEHQFALQLVEDEVPVAAPLFFNDSTLHQHQGFYFA
                     VFPSLGGRQFEADNLDQMEWVGRYLGRLHQTGRKQRFTARPEIGVQEYLLEPRQVFEQA
                     TLIPSGLKADFLKATDKLIAAVMEQWHGRGNTLRLHGDCHAGNILWRDGPLFVDLDDAR
                     TGPAIQDLWMLLNGDKAEQRMQLETIVEAYEEFSPFNSDEIALIEPLRAMRLVYYLAWL
                     LRRWDDPAFPVNFPWLTGEDYWRGQTSTFLEQVKVLQEPPLQLTPMY"
     PFAM_domain     4080..4748
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01636.25"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2809_0036"
                     /evalue="8.40E-45"
                     /label="ctg1_2809"
                     /locus_tag="ctg1_2809"
                     /protein_end="254"
                     /protein_start="31"
                     /score="153.6"
                     /tool="antismash"
                     /translation="TPLNSYENRVYQFQDEERHRYVVKFYRPERWSAEQILEEHQFALQ
                     LVEDEVPVAAPLFFNDSTLHQHQGFYFAVFPSLGGRQFEADNLDQMEWVGRYLGRLHQT
                     GRKQRFTARPEIGVQEYLLEPRQVFEQATLIPSGLKADFLKATDKLIAAVMEQWHGRGN
                     TLRLHGDCHAGNILWRDGPLFVDLDDARTGPAIQDLWMLLNGDKAEQRMQLETIVEAYE
                     E"
     CDS             5001..5624
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2810"
                     /sec_met_domain="TIGR03651 (E-value: 0.0003, bitscore:
                     19.2, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVWLALAGMILAFSASAAQITDGKQYITLDKPIAGEPQVLEFF
                     SFYCPHCYQFEEVLHVSDNVRQKLPEGTKMTKYHVEFLGPLGKDLTQAWAVAIALGVED
                     KITAPMFEAVQKTQTVQSVADIRKVFVDAGVKGEDYDAAWNSFVVKSLVAQQEKAAADL
                     QLQGVPAMYVNGKYQLNPQGMDTSNMDVFVAQYADTVKQLVEKK"
     PFAM_domain     5118..5588
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01323.22"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2810_0037"
                     /evalue="8.60E-28"
                     /label="ctg1_2810"
                     /locus_tag="ctg1_2810"
                     /protein_end="196"
                     /protein_start="39"
                     /score="97.5"
                     /tool="antismash"
                     /translation="QVLEFFSFYCPHCYQFEEVLHVSDNVRQKLPEGTKMTKYHVEFLG
                     PLGKDLTQAWAVAIALGVEDKITAPMFEAVQKTQTVQSVADIRKVFVDAGVKGEDYDAA
                     WNSFVVKSLVAQQEKAAADLQLQGVPAMYVNGKYQLNPQGMDTSNMDVFVAQY"
     CDS             complement(5674..6573)
                     /locus_tag="ctg1_2811"
                     /transl_table=11
                     /translation="MSRLLAAITLPLSIALTILVTIICSVPIIVAGLIKLLVPIPAVWR
                     SISVFCNFMMYCWCEGLALLLHLNPWLKWDVEGLEGLNKKNWYLLISNHHSWADIVVLC
                     VLFRKHIPMNKYFLKQQLAWVPFIGLACWALDMPFMRRYSRSYLIRHPERRGKDVETTR
                     RSCEKFRAHPTTIVNFVEGSRFTEAKKHETRSPYDNLLPPKAAGIAMALNVLGSQFDKL
                     LNVTLCYPENNTKPFYDMLSGRLTRIVVRINLVPIGEELHGDYVNDKNFKRGFQRWLNG
                     LWEEKDRQLTDIMRDKER"
     PFAM_domain     complement(5941..6351)
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2811_0038"
                     /evalue="1.50E-12"
                     /label="ctg1_2811"
                     /locus_tag="ctg1_2811"
                     /protein_end="211"
                     /protein_start="74"
                     /score="47.4"
                     /tool="antismash"
                     /translation="DVEGLEGLNKKNWYLLISNHHSWADIVVLCVLFRKHIPMNKYFLK
                     QQLAWVPFIGLACWALDMPFMRRYSRSYLIRHPERRGKDVETTRRSCEKFRAHPTTIVN
                     FVEGSRFTEAKKHETRSPYDNLLPPKAAGIAMA"
     CDS             6970..9762
                     /locus_tag="ctg1_2812"
                     /transl_table=11
                     /translation="MVQIPENPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNM
                     LRSLILQYQPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHKMVKAMGL
                     PLMAVPGVEADDVIGTLAREAERAGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPD
                     EVVSKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIA
                     ALSFRGAKTMAAKLEQNKDVAYLSYQLATIKTDVELELTCEELEVQPPAADDLLALFRQ
                     YEFKRWTTDVEAGKWLQAKGGKPAAKPAEPAAAAQAEAEDEPASALSAEHYVTILDEAT
                     LVTWIDKLKQAPLFAFDTETDSLDNISANMVGLSFAVEPGVAAYVPVAHDYLDAPDQIP
                     RERVLALLKPLLEDEKLLKVGQNLKYDRGILANYDIELRGIAFDTMLESYILDSVAGRH
                     DMDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPK
                     LQQHEGPLNIFKHIEMPLVPVLSRVERNGVKIDPAVLHAHSLEIAQRLVELEQRAHEIA
                     GEVFNLSSTKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGL
                     AKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQA
                     FIAPEDYVIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLDSVSS
                     EQRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAK
                     EQGYVETLDGRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDEWLRK
                     EQPRVRMIMQVHDELVFEVHKDELDAVSKKIHELMENSTTLAVPLLVEVGSGENWDQAH
                     "
     PFAM_domain     6994..7479
                     /aSDomain="5_3_exonuc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02739.18"
                     /description="5'-3' exonuclease, N-terminal resolvase-like
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2812_0039"
                     /evalue="8.00E-55"
                     /label="ctg1_2812"
                     /locus_tag="ctg1_2812"
                     /protein_end="170"
                     /protein_start="8"
                     /score="185.1"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHKMVKAMGLPLMAVPGV
                     EADDVIGTLAREAERAGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPDEVVSKYG"
     aSDomain        6994..9759
                     /aSDomain="TIGR00593"
                     /aSTool="tigrfam"
                     /description="pola: DNA polymerase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_2812_0017"
                     /evalue="2.00E-286"
                     /identifier="TIGR00593"
                     /label="ctg1_2812"
                     /locus_tag="ctg1_2812"
                     /protein_end="930"
                     /protein_start="8"
                     /score="950.9"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHKMVKAMGLPLMAVPGV
                     EADDVIGTLAREAERAGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPDEVVSKYGV
                     PPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAALSFRGAK
                     TMAAKLEQNKDVAYLSYQLATIKTDVELELTCEELEVQPPAADDLLALFRQYEFKRWTT
                     DVEAGKWLQAKGGKPAAKPAEPAAAAQAEAEDEPASALSAEHYVTILDEATLVTWIDKL
                     KQAPLFAFDTETDSLDNISANMVGLSFAVEPGVAAYVPVAHDYLDAPDQIPRERVLALL
                     KPLLEDEKLLKVGQNLKYDRGILANYDIELRGIAFDTMLESYILDSVAGRHDMDSLSDR
                     WLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPKLQQHEGPL
                     NIFKHIEMPLVPVLSRVERNGVKIDPAVLHAHSLEIAQRLVELEQRAHEIAGEVFNLSS
                     TKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYT
                     DKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYV
                     IVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLDSVSSEQRRSAKA
                     INFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETL
                     DGRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDEWLRKEQPRVRMI
                     MQVHDELVFEVHKDELDAVSKKIHELMENSTTLAVPLLVEVGSGENWDQAH"
     PFAM_domain     7480..7782
                     /aSDomain="5_3_exonuc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01367.22"
                     /description="5'-3' exonuclease, C-terminal SAM fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2812_0040"
                     /evalue="1.00E-30"
                     /label="ctg1_2812"
                     /locus_tag="ctg1_2812"
                     /protein_end="271"
                     /protein_start="170"
                     /score="106.2"
                     /tool="antismash"
                     /translation="VPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLY
                     AEPEKIAALSFRGAKTMAAKLEQNKDVAYLSYQLATIKTDVELELTCEELEVQPPA"
     PFAM_domain     7963..8526
                     /aSDomain="DNA_pol_A_exo1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01612.22"
                     /description="3'-5' exonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2812_0041"
                     /evalue="1.10E-41"
                     /label="ctg1_2812"
                     /locus_tag="ctg1_2812"
                     /protein_end="519"
                     /protein_start="331"
                     /score="142.6"
                     /tool="antismash"
                     /translation="YVTILDEATLVTWIDKLKQAPLFAFDTETDSLDNISANMVGLSFA
                     VEPGVAAYVPVAHDYLDAPDQIPRERVLALLKPLLEDEKLLKVGQNLKYDRGILANYDI
                     ELRGIAFDTMLESYILDSVAGRHDMDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALE
                     EAGRYAAEDADVTLQLHLKMWPKLQ"
     PFAM_domain     8629..9750
                     /aSDomain="DNA_pol_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00476.22"
                     /description="DNA polymerase family A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_2812_0042"
                     /evalue="6.80E-159"
                     /label="ctg1_2812"
                     /locus_tag="ctg1_2812"
                     /protein_end="927"
                     /protein_start="553"
                     /score="529.0"
                     /tool="antismash"
                     /translation="LHAHSLEIAQRLVELEQRAHEIAGEVFNLSSTKQLQTILFEKQGI
                     KPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRV
                     HTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYVIVSADYSQIELRIM
                     AHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLDSVSSEQRRSAKAINFGLIYGMSAFGL
                     ARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRAQAKEQGYVETLDGRRLYLPDIKSSN
                     GARRAGAERAAINAPMQGTAADIIKRAMIAVDEWLRKEQPRVRMIMQVHDELVFEVHKD
                     ELDAVSKKIHELMENSTTLAVPLLVEVGSGENWD"
ORIGIN
        1 ccgtcgtgaa gagggaaaca acccagaccg ccagctaagg tcccaaagtc atggttaagt
       61 gggaaacgat gtgggaaggc acagacagcc aggatgttgg cttagaagca gccatcattt
      121 aaagaaagcg taatagctca ctggtcgagt cggcctgcgc ggaagatgta acggggctaa
      181 accatgcacc gaagctgcgg cagcgacact atgtgttgtt gggtagggga gcgttctgta
      241 agcctgcgaa ggtggcctgt gagggttgct ggaggtatca gaagtgcgaa tgctgacata
      301 agtaacgata aagcgggtga aaagcccgct cgccggaaga ccaagggttc ctgtccaacg
      361 ttaatcgggg cagggtgagt cgacccctaa ggcgaggccg aaaggcgtag tcgatgggaa
      421 acaggttaat attcctgtac ttggtgttac tgcgaagggg ggacggagaa ggctatgtta
      481 gccgggcgac ggttgtcccg gtttaagcat gtaggcggag gttccaggta aatccggtac
      541 cttttaacgc tgaggtgtga tgacgaggca ctacggtgct gaagtaacaa atgccctgct
      601 tccaggaaaa gcctctaagc atcaggtaac attaaatcgt accccaaacc gacacaggtg
      661 gtcaggtaga gaataccaag gcgcttgaga gaactcgggt gaaggaacta ggcaaaatgg
      721 tgccgtaact tcgggagaag gcacgctggt gtgtaggtga agtccctgcg gatggagctg
      781 agaccagtcg aagataccag ctggctgcaa ctgtttatta aaaacacagc actgtgcaaa
      841 cacgaaagtg gacgtatacg gtgtgacgcc tgcccggtgc cggaaggtta attgatgggg
      901 ttatccgtaa ggagaagctc ttgatcgaag ccccggtaaa cggcggccgt aactataacg
      961 gtcctaaggt agcgaaattc cttgtcgggt aagttccgac ctgcacgaat ggcgtaatga
     1021 tggccaggct gtctccaccc gagactcagt gaaattgaac tcgctgtgaa gatgcagtgt
     1081 acccgcggca agacggaaag accccgtgaa cctttactat agcttgacac tgaacattga
     1141 gccttgatgt gtaggatagg tgggaggctt tgaagcgtgg acgccagtct gcgtggagcc
     1201 aaccttgaaa taccaccctt taatgtttga tgttctaacg taggcccctg accggggttg
     1261 cggacagtgt ctggtgggta gtttgactgg ggcggtctcc tcccaaagag taacggagga
     1321 gcacgaaggt tagctaatcc tggtcggaca tcaggaggtt agtgcaatgg cataagctag
     1381 cttgactgcg agcgtgacgg cgcgagcagg tgcgaaagca ggtcatagtg atccggtggt
     1441 tctgaatgga agggccatcg ctcaacggat aaaaggtact ccggggataa caggctgata
     1501 ccgcccaaga gttcatatcg acggcggtgt ttggcacctc gatgtcggct catcacatcc
     1561 tggggctgaa gtaggtccca agggtatggc tgttcgccat ttaaagtggt acgcgagctg
     1621 ggtttagaac gtcgtgagac agttcggtcc ctatctgccg tgggcgctgg agaattgagg
     1681 ggggctgctc ctagtacgag aggaccggag tggacgcatc actggtgttc gggttgtcat
     1741 gccaatggca ctgcccggta gctaaatgcg gaagagataa gtgctgaaag catctaagca
     1801 cgaaacttgc cccgagatga gttctccctg agactataag tctcctgaag gaacgttgaa
     1861 gacgacgacg ttgataggcc gggtgtgtaa gcgcagcgat gcgttgagct aaccggtact
     1921 aatgaaccgt gaggcttaac cttacaacgc cgaagctgtt ttggcggatt tgagagagaa
     1981 ttttcagctc tgattcagag tccgaaggat tttgcgctga gacaaggcgg caaacgaggc
     2041 gatggaagga gcatacataa gtatgtgact gacactcgcg agagcagcca acgcagtatg
     2101 agtgcaaaag acacaggacg agcacaaaga atttgcctgg cggcactagc gcggtggtcc
     2161 cacctgaccc catgccgaac tcagaagtga aacgccgtag cgccgatggt agtgtggggt
     2221 ctccccatgt gagagtaggg aactgccagg catcaaacaa gtgaagagcc catcctgacg
     2281 gatgggcttt ttgcgtttct gtggaccggg cagcgtgccg gcatgtctcc ccggtggcgc
     2341 tgcgcttacc ggggctacgg attcgcaccc gccctgcacg acctgtagcc cggacaaggt
     2401 gcgctgcacc gcctccgggg aggcccctgt ctgccgatgc cattcattaa cgtctgtgtt
     2461 aagaagcaac cctaccgata aactgctaat gcctctctaa ccaattcgca ataaatgtcg
     2521 cgatctgttg aatatcattt aaatccaact gcggaagcga ggtcgcgatg ggcatatcgc
     2581 tggccacggc gatggtatgt ttatcaatta tcagctcttc tacacgatgg ccgctgtttt
     2641 gccgaaaaag taggatcttc ggcacgggtt catgtttgaa cccctccact aaaaccaggt
     2701 ccagtttgct ggcatccatt cgactgacaa gccacgtgag atctaattcc ggcgtctctg
     2761 gcgtctcagt catcaacgcc cagcgctgtt cgctggcgac aatagtctgc gcagcgcccg
     2821 ccttacgtaa ttcatagcta tctttgccgg gtttatcgac gtccatatca tgatgggtat
     2881 gttttatcag cccgggacgc agacctctga cacaaagctc agggataaga cgctttaata
     2941 atgttgtttt tccggtaccg ctccatgcgg cgatcgccag taatggggtc atgatggctc
     3001 ctgcatctgc tgcaaatctt caagcgtatt tacattgatg aacgctgatt tcacatcgct
     3061 gaaattcacc gggcgcccac ccacttgtcg cataaagacc atcaccctgc gctctccatg
     3121 agccagataa gcctccagtt ccggaatgat ttgacgatga actaatgcaa cggcgggatg
     3181 atcccgttcg ccgtcatggg cccaaacgac cggcgcggcc cctctctgct ggataaagcg
     3241 ctccaccaaa aaggacggaa tgaacggcgt gtcgcagggg caaaaaacaa accatgtgct
     3301 cgcgacctgc tgcatcacag caagcattcc ggccagcggc ccctgataac cctcctgtat
     3361 gtctcgaaag accggatatc cgctggcacg ccactgttca agatgacgat tggcgctaat
     3421 gactaactca tctacctgcg gggctaatgt ctccgcgacg tgacgccaga gagggcgacc
     3481 atttagcgcc tgtaatcctt tatcaatgcc gcccattcgc gtggctttgc cgcctgccag
     3541 cacgacgccg gttatcgcct cgctttgcat ctgaatatcg cctctttcat tgtgggattg
     3601 accctgttaa cttgtcccta tcaagagtaa ggagcatgac catgaaatgt aaacgtctga
     3661 atgaagtaat tgaactcctc cagcctgcct ggcagaaaga gcctgaactg aatctgatgc
     3721 aatttttgca gaaactggcg aaagaggctg gctatgatgg cgaactgagc gatctttccg
     3781 acgatattct gatctatcac ctgaagatgc gtgactcttc taaagatgct gtcattcctg
     3841 gtattcagaa ggattatgaa gaggacttta aaaccgcgct gctgcgcgcc cgcggggtaa
     3901 taaaagagta aaaggttgta agcgctgccg cgtaaagtgc aatgagatga tatcctgaac
     3961 tattcgtacg attatcggaa gtcaggatgc acgataaggc ttttactttt cagacgcttc
     4021 gcccggatac cattatcgat gggttattcg atctgggtat gcgggtggac tccggtctca
     4081 ccccgctaaa cagctatgag aaccgcgttt atcagttcca ggacgaagag cgccatcgct
     4141 atgtggtaaa gttctatcgt cctgagcgct ggtccgcaga acagatcctt gaagaacacc
     4201 agtttgcgct tcagcttgta gaagatgaag tgcccgttgc tgcgccgctc ttctttaacg
     4261 acagcacgct tcatcagcat cagggattct actttgccgt tttcccaagc cttggcggtc
     4321 gtcagttcga agcggataac cttgatcaga tggaatgggt tggccgctat ctggggcgcc
     4381 tgcaccagac gggccgcaaa cagcgcttta ctgcccgccc ggaaattggc gtccaggagt
     4441 acctgctgga accgcgccag gtgtttgaac aggcgacgct gatcccctct ggcctgaagg
     4501 ccgatttcct gaaggcgacc gataaactca ttgctgccgt catggagcaa tggcacggcc
     4561 gcgggaacac gttacgcctg cacggtgact gccatgcggg taatatcctc tggcgcgacg
     4621 ggccactgtt tgtcgactta gacgatgcgc gaaccggccc ggcgattcag gatctgtgga
     4681 tgctgctcaa cggtgataag gctgaacagc gtatgcagct ggagaccatt gtcgaggcct
     4741 atgaggaatt cagccccttt aacagcgatg aaatcgcgct aattgaacct ttacgcgcta
     4801 tgcgactggt ttattatctg gcgtggttgc tcagacgctg ggacgatccc gctttcccgg
     4861 tcaatttccc ctggttaacc ggggaggatt actggcgggg gcagacgtcg acttttcttg
     4921 agcaggtgaa ggttctacag gaacccccgc ttcagttaac gccaatgtat taatgtgata
     4981 tatccaggag agagtaaatc atgaaaaaag tttggctggc gctggctggt atgattctgg
     5041 cttttagtgc atccgctgcc cagatcaccg atggcaagca gtacatcacc cttgataagc
     5101 cgattgctgg cgagccgcag gtgctcgagt tcttctcatt ctactgcccg cactgctacc
     5161 agtttgaaga agtgctgcat gtttctgaca atgtgcgtca gaaactgccg gaaggcacca
     5221 aaatgaccaa ataccacgtt gagttcctgg gccctctggg caaggatctg acgcaggcgt
     5281 gggcggtggc catcgcgctg ggtgttgaag ataaaattac tgcgccgatg ttcgaagccg
     5341 tgcagaaaac ccagaccgtg cagagcgtgg ctgacattcg taaagtgttt gtcgacgctg
     5401 gcgtgaaagg ggaagactac gatgccgcat ggaatagctt cgtggtgaaa tctctggtcg
     5461 ctcagcaaga gaaagcggca gccgatctgc agctgcaggg ggtaccggct atgtatgtta
     5521 atggtaaata ccagctgaac ccgcagggga tggacaccag caatatggat gtcttcgtcg
     5581 ctcagtatgc ggataccgtg aagcaactgg tagagaagaa ataaaaaaaa cgccggtcac
     5641 tgaccggcgt taccttagct attctggcag tgactacctt tctttgtccc gcatgatgtc
     5701 agtcaactga cggtctttct cttcccatag cccattgagc cagcgctgga agccgcgctt
     5761 aaagttctta tcgttaacgt aatcgccgtg cagctcttca ccaataggaa ccagattgat
     5821 acgtactaca atgcgcgtca ggcggccgct taacatatcg taaaacggct ttgtattatt
     5881 ctccgggtag cacagcgtga cattcagtag tttatcgaac tgcgaaccga gcacgtttaa
     5941 cgccatggcg atacctgccg ctttaggcgg tagcaggtta tcgtaaggcg agcgcgtctc
     6001 gtgctttttg gcttcggtaa aacgcgagcc ttccacaaaa ttgacgatag tcgtcggatg
     6061 cgcgcgaaat ttttcacatg aacggcgggt ggtttcgaca tctttaccgc ggcgttccgg
     6121 gtgtctaata aggtaactgc gtgaatagcg gcgcataaag ggcatatcca acgcccagca
     6181 ggcgaggccg atgaagggta cccacgccag ctgttgttta aggaagtact tattcatcgg
     6241 aatatgcttg cggaacagca cgcacagcac cacgatatct gcccagctat ggtggttact
     6301 gatcagcaga taccagttct ttttatttaa gccttccaga ccctcgacgt cccatttaag
     6361 ccagggattg agatgcaaca gcagcgccag cccttcgcac cagcaataca tcataaaatt
     6421 gcaaaaaaca gatatagagc gccataccgc tggaatgggg accagcagtt taatcagccc
     6481 ggcgacgatg atcggtacag agcagataat ggtgactaag atggttaagg cgatactcag
     6541 cggaagtgtt atcgcagcga gtaatctcga catagttagt ttattcagaa agttaggctg
     6601 acaaagagcg cctttaagct gcgcaagggg ctgattttac cagaaaacgc ggcaaatgac
     6661 gggtcttacg agaacagaaa aaaacaagga tcttctatcc acatggaaca ttgggtcatc
     6721 aaattgatac caggatcgtc gatctgtttt taattaactg atatataaag agtaatagta
     6781 tttgttcatt tattttcagg ggcggtaaag ctgacgctgt aaaactatac acaaagttat
     6841 ccacaagcaa agttcttatg cgatcgcgac gatcgttgaa tcttttccgc gaaatgcggg
     6901 aaaaattcag gatttcatgc ccgtctgtgg catcctttag ccataatctg ataaacaggc
     6961 acggaaatta tggttcagat cccagaaaac cctctcatcc tcgttgacgg ctcatcctat
     7021 ctttatcggg cgtatcatgc gtttccgccg ctgactaaca gcgcagggga gccgaccggg
     7081 gctatgtacg gcgtactgaa tatgctgcgc agtttgatcc tgcagtatca accgactcac
     7141 gccgtcgtgg tctttgatgc gaaagggaaa accttccgtg atgaattgtt cgaacattac
     7201 aagtcccacc gcccgccgat gccggacgat ctgcgcgcgc agattgagcc gttgcataag
     7261 atggtgaaag cgatggggct gccgctaatg gcagttccgg gtgttgaagc cgacgatgtg
     7321 attggcaccc tggcgcggga agcggaaagg gcgggtcgtc cggtgctgat cagcaccggt
     7381 gataaagaca tggctcagct ggtgacgccg gggatcaccc taatcaatac catgactaac
     7441 accatccttg gaccggatga ggtggtctcc aagtatggcg tcccgccgga gctgattatc
     7501 gatttcctgg cactgatggg cgactcttcg gataacattc ctggcgtgcc gggcgtgggc
     7561 gagaagaccg cccaggcgct gctgcaaggc cttggcggcc ttgatacgct gtatgcggaa
     7621 ccggagaaaa ttgctgcact gagcttccgc ggcgcgaaaa cgatggcggc gaagctggag
     7681 cagaacaagg acgtggctta tctctcttat cagctggcga ccattaaaac cgacgtcgag
     7741 ctggagctca catgcgaaga gctggaggtg cagccaccgg cggctgacga tctgctggcg
     7801 ctgttcaggc agtatgagtt taagcgctgg acaaccgacg tcgaggccgg gaaatggctg
     7861 caagcgaagg gcggcaaacc ggccgctaaa cctgcagagc ctgcggcagc ggcacaggca
     7921 gaagcagagg atgaaccggc ctccgccctt tcagcagagc actacgtcac tatccttgat
     7981 gaggccacgc tggtcacctg gatcgataag ctgaagcaag cgccgctctt tgcctttgat
     8041 acggaaaccg acagcctgga taatatctct gccaatatgg tcggtctttc attcgctgtt
     8101 gagcctggcg tggccgccta tgtccctgtg gcgcatgatt atcttgatgc gccggatcag
     8161 atcccccgcg agcgcgtact ggcgttactt aaaccgctgc tggaggatga gaagctgctc
     8221 aaggtcgggc aaaatctcaa atacgatcgc ggtattttgg ccaactatga cattgagctg
     8281 cgcgggattg cattcgatac catgctggaa tcctacattc tcgacagcgt ggcgggccgc
     8341 cacgatatgg acagtctttc cgaccgctgg ctgaagcata aaaccattac ctttgaagag
     8401 atcgctggta aaggtaagaa ccagctcacc tttaaccaga ttgcactgga ggaggctggc
     8461 cgctacgcgg cggaagatgc cgacgtcacg ctccagctgc atctgaagat gtggccgaag
     8521 ctgcagcagc atgaaggtcc gctgaatatc tttaagcata tcgaaatgcc gctggtgccg
     8581 gtgctgtctc gggttgagcg caatggcgtg aaaatcgacc ctgccgtgct gcatgcgcat
     8641 tccctggaga tcgcccagcg tctggttgag ctggagcagc gcgcacatga gattgccggg
     8701 gaagtgttta atctctcctc cactaaacag ctgcaaacga tcctgtttga gaaacagggt
     8761 atcaagccgc tgaagaaaac gccgggcggt gcgccatcca cgtctgaaga ggtcctggag
     8821 gagctggcgc tggattatcc gttgccaaaa gtgattctgg agtatcgcgg gctggcgaaa
     8881 ctgaagtcga cctataccga taaactgccg ctgatgatta accctaaaac ggggcgcgtg
     8941 catacctcct atcatcaggc ggttactgcc actggccgtt tgtcatctac cgatccaaac
     9001 ctgcaaaata ttccagtgcg taacgaagaa ggacggcgca ttcgccaggc gtttatcgcg
     9061 ccggaagatt acgtcattgt ctcagcggac tactcgcaaa tcgaactgcg tattatggcg
     9121 cacctgtcgc gggataaagg cctgctaacc gccttcgctg aagggaaaga tattcaccgg
     9181 gcgacggcgg ctgaagtgtt tggcttacca ctggacagcg tcagcagcga acagcgccgc
     9241 agtgcgaaag ccatcaactt cggtctgatc tacggcatga gcgccttcgg cctggcccgc
     9301 caactgaaca tcccgcgtaa agaagcacag aagtatatgg atctttattt cgagcgttac
     9361 ccgggcgtcc tggagtatat ggagcgcacc cgcgctcagg cgaaagagca agggtacgtt
     9421 gaaacgctgg atggccgtcg actctatctg ccggatatta aatccagcaa tggtgcccgt
     9481 cgcgccggcg cggaacgtgc ggcgatcaac gccccgatgc aggggacagc ggcagacatt
     9541 atcaagcggg cgatgattgc tgttgatgaa tggctgcgga aggagcaacc tcgcgtgcgg
     9601 atgatcatgc aggttcacga tgaactggtc tttgaagtgc ataaagatga gctcgatgcc
     9661 gtgtcgaaaa aaatccatga actgatggag aacagcacta cgctggcggt gccgctgctg
     9721 gtggaagtcg gtagtggcga aaactgggat caagcgcact aagtatacaa agcgcaaagc
     9781 gattttctgt aagtaagcaa cataacttat agcgttttgt gaggatcatt tgaatttgct
     9841 atgtaaatag tgaaaaaaaa ctacaaaaaa tgctttatcc gtgagcgaaa gaagagtaga
     9901 gttaatcgcg tagggtacag aggtaagatg ttctatcttt cagacctttt acttcacgta
     9961 atcggatttg gctgaatatt ttagccgccc cggtcattta tgaccggggc gttttttatt
    10021 gcgcgaaaga aaagtttgat gcagttaaaa gcgcgtaata tgaacgtccg gatagggcgc
    10081 tacgcgccgt tatccggaaa aagcgggggt tactcggcgt cttcaacggc ttcttgcggc
    10141 gggatttcgt taaaccagct atccagcttc tgtcgcagct tatccacgcc agattttttc
    10201 agcgaagaga aaggttcaac ctgaatatcg ccattgaagg ccagtaccgc ttcacgcacc
    10261 atattcactt gcgctttacg cgcgccgctg gcgagcttat cggctttggt caacagcacc
    10321 agcacctgaa tatcgctttc taccgcccac tcgatcattt gctgatcgag atctttaagc
    10381 gggtggcgaa tatccattag caccaccagg cccttcaggc acagacgttt ttccaggtac
    10441 tctcccagcg cgcgctgcca cttgatcttc atctcttcag gtacttgcgc ataaccatag
    10501 ccgggcaggt caaccaggcg tttgccctcg gcgacttcga acaggttaat cagctgcgta
    10561 cgtccaggag tcttggaggt acgcgccagg ctcttctggt tggtcagcgt atttagcgcg
    10621 ctgg
//
