LOCUS       c00032_NZ_QICD..       10582 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_QICD01000032.1 Paraeggerthella hongkongensis strain DSM 16106
            DSM16106T_contig_032, whole genome shotgun sequence.
ACCESSION   NZ_QICD01000032
VERSION     NZ_QICD01000032
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:19:15
            Original ID  :: NZ_QICD01000032.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10582
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10582
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4769:5582](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4770..5582)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10582
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10582
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             3..1010
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 195.4; E-value: 1.8e-59)"
                     /gene_kind="other"
                     /locus_tag="ctg32_1"
                     /transl_table=11
                     /translation="RADLEEALLEVAAYKELMRDPKAAGPESLSKRRLVGLGEKLRRDS
                     GCSLARILTFLGISKSTYHYHRARLDSPSGMPDEDFDEAVVEAFSRNGGIYGYRRLKAE
                     LEGEGVRAPERKVREAMARLGLVARCSRSERKWSSYKGEISDAPDNLLVGSRGRHDFSA
                     GAPDEVWLTDITEMKGRDGKLYLSVIVDCFDGKAVAWRASTSPNAELADSTLRDAIATL
                     EEGRRPIVHSDRGAHYRWKGWIALCEEAGLVRSMSRKGHSPDNAACEGFFGRAKVELFH
                     SLVRAGASVAELSEAVERYMRWYNDGRLKAFKSDGGRASYETIRDRRKRLGLAA"
     PFAM_domain     246..398
                     /aSDomain="HTH_21"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13276.8"
                     /description="HTH-like domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_1_0001"
                     /evalue="1.50E-09"
                     /label="ctg32_1"
                     /locus_tag="ctg32_1"
                     /protein_end="132"
                     /protein_start="81"
                     /score="38.0"
                     /tool="antismash"
                     /translation="DEAVVEAFSRNGGIYGYRRLKAELEGEGVRAPERKVREAMARLGL
                     VARCSR"
     PFAM_domain     495..785
                     /aSDomain="rve"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00665.28"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_1_0002"
                     /evalue="4.20E-17"
                     /label="ctg32_1"
                     /locus_tag="ctg32_1"
                     /protein_end="261"
                     /protein_start="164"
                     /score="62.4"
                     /tool="antismash"
                     /translation="APDEVWLTDITEMKGRDGKLYLSVIVDCFDGKAVAWRASTSPNAE
                     LADSTLRDAIATLEEGRRPIVHSDRGAHYRWKGWIALCEEAGLVRSMSRKGH"
     PFAM_domain     807..932
                     /aSDomain="rve_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13333.8"
                     /description="Integrase core domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_1_0003"
                     /evalue="3.30E-06"
                     /label="ctg32_1"
                     /locus_tag="ctg32_1"
                     /protein_end="310"
                     /protein_start="268"
                     /score="27.3"
                     /tool="antismash"
                     /translation="EGFFGRAKVELFHSLVRAGASVAELSEAVERYMRWYNDGRLK"
     CDS             complement(1153..2511)
                     /locus_tag="ctg32_2"
                     /transl_table=11
                     /translation="MGLLVAWLCCTHVTFIFPGFGFPDTSLAAINYGMRVGDVGTFLAL
                     ALFSNRIGRLSSHKKASAAFVIITAAGTALQGLVLFPAGSAAAILFAVSAVTAIGGAFL
                     FCLWAEAYSQMGTTRTLMYGAGSCITAAVVSFAVSTMQEPYAIAATALLPLASLACALL
                     SLRILPTEPARSANTRYPLPWKLLGIMTAAGLLSGTAGSVIPDATWMGAIHRVVATGLA
                     GIVIIVMALTLKDRIDVRFLAKVGLPLSIIALAAIPFADPQWGFAVSFSLKLAYVWFTM
                     FVLLMLANIAFRFEVPTLRLFALARALSELGIFAGIGIRQCLLQNSLFFNEAFLVGLAL
                     GGIVLVLVCALVWTSEKSVNGDWGASGITLDGQLHVPGPRERFMARCESLAERYGLTAR
                     ETEIMGLIAQRKSRAEIEQQLFLSENTVKTHVRHLYAKLGAHSKADVIALFEE"
     PFAM_domain     complement(1165..1326)
                     /aSDomain="GerE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00196.21"
                     /description="Bacterial regulatory proteins, luxR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_2_0004"
                     /evalue="1.30E-15"
                     /label="ctg32_2"
                     /locus_tag="ctg32_2"
                     /protein_end="449"
                     /protein_start="395"
                     /score="56.8"
                     /tool="antismash"
                     /translation="LTARETEIMGLIAQRKSRAEIEQQLFLSENTVKTHVRHLYAKLGA
                     HSKADVIAL"
     CDS             2999..4648
                     /locus_tag="ctg32_3"
                     /transl_table=11
                     /translation="MSEITKGLSRRSFLTLGGVAALGGAAALAGCAPQASSESKSESAK
                     GDDAAMKTADQTKECDIAVVGAGGAGMWAAVEAVRAGKSVVVIEKGANVGVANGSLAGG
                     PFTVGSKLQQEAGIDFTVEEAFKHIMEYGHWSTNAAAIKAAVEISGETIDQFTSDFGVP
                     TGLRPDNYGAGHASVRANFQSDPKDSKTQTKGEARMKPLQEFVESEGGEFLFNTAGKRL
                     IMENGACVGVQCEGEGVIDVKAKQVIVATGGFLGSADMMLEKFGTFVNPLGNILSVGEG
                     IDMVQAAGGQVSTQWGIAGNEFAGSNQKADGLYDRKNAAFTVGIYGTLLVNNQGRRFSN
                     EGKFANLPLALGGAISLVGGKYYAVVDQTYVDGLNAGTDAWTLCGSDAENWRTGMMTLK
                     GKALENVQANFDAAVDAGWAFKADSIEALTEAIDAPDLTKTVEAYNAACAAGKDDQFYK
                     PACFLQPVAAGPFYAMQYEPSAWVTIGGIRTNDRLQAIDAEGAAIPGLYVAGADNGTLM
                     SAPYTDYEGYSLMCAYCGGRLAGQYAAAAIDA"
     PFAM_domain     3179..4549
                     /aSDomain="FAD_binding_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00890.26"
                     /description="FAD binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_3_0005"
                     /evalue="5.00E-47"
                     /label="ctg32_3"
                     /locus_tag="ctg32_3"
                     /protein_end="517"
                     /protein_start="60"
                     /score="161.0"
                     /tool="antismash"
                     /translation="DIAVVGAGGAGMWAAVEAVRAGKSVVVIEKGANVGVANGSLAGGP
                     FTVGSKLQQEAGIDFTVEEAFKHIMEYGHWSTNAAAIKAAVEISGETIDQFTSDFGVPT
                     GLRPDNYGAGHASVRANFQSDPKDSKTQTKGEARMKPLQEFVESEGGEFLFNTAGKRLI
                     MENGACVGVQCEGEGVIDVKAKQVIVATGGFLGSADMMLEKFGTFVNPLGNILSVGEGI
                     DMVQAAGGQVSTQWGIAGNEFAGSNQKADGLYDRKNAAFTVGIYGTLLVNNQGRRFSNE
                     GKFANLPLALGGAISLVGGKYYAVVDQTYVDGLNAGTDAWTLCGSDAENWRTGMMTLKG
                     KALENVQANFDAAVDAGWAFKADSIEALTEAIDAPDLTKTVEAYNAACAAGKDDQFYKP
                     ACFLQPVAAGPFYAMQYEPSAWVTIGGIRTNDRLQAIDAEGAAIPGLYVAGADNGTLM"
     CDS             complement(4770..5582)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_4"
                     /sec_met_domain="Linocin_M18 (E-value: 3.2e-83, bitscore:
                     269.7, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYLARESADLSAELWNRIDNAVISTARQQLTARRFLKTYGPLGP
                     GATTVAVDSVAKEEVLEDGIGRIVGRTQLELPMLYEDFTLLGRDLELATQTGMPLDLAP
                     AVTAAKKAARREDGLVLNGSQLLGTEGLLTAKGANKMKRADWNKGENGFSDVAAAVSQL
                     AKTGYLGRYALAVAPDLFLALQRLQPNTGMLEIDRIKKLIGDNVYMTSAIDQGKAVLVC
                     AEPEYLDLALGLDLSVGYAELTDFNHHFRIMETAALRIKDPAAIVVFE"
     PFAM_domain     complement(4815..5582)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_4_0006"
                     /evalue="5.40E-79"
                     /label="ctg32_4"
                     /locus_tag="ctg32_4"
                     /protein_end="256"
                     /protein_start="0"
                     /score="265.2"
                     /tool="antismash"
                     /translation="MDYLARESADLSAELWNRIDNAVISTARQQLTARRFLKTYGPLGP
                     GATTVAVDSVAKEEVLEDGIGRIVGRTQLELPMLYEDFTLLGRDLELATQTGMPLDLAP
                     AVTAAKKAARREDGLVLNGSQLLGTEGLLTAKGANKMKRADWNKGENGFSDVAAAVSQL
                     AKTGYLGRYALAVAPDLFLALQRLQPNTGMLEIDRIKKLIGDNVYMTSAIDQGKAVLVC
                     AEPEYLDLALGLDLSVGYAELTDFNHHFRIMETA"
     CDS             complement(5699..6025)
                     /locus_tag="ctg32_5"
                     /transl_table=11
                     /translation="MTNAELMQALRLDIAGELEAIYLYESHYLATDDPAAKAVLADIRD
                     EEKAHMGELITLMRHLDPKETEFFLDGEGEVQEMLEDLGIKTDGHIAPAPAEPAAAPTV
                     GDLS"
     PFAM_domain     complement(5834..6007)
                     /aSDomain="COQ7"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03232.15"
                     /description="Ubiquinone biosynthesis protein COQ7"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_5_0007"
                     /evalue="5.90E-07"
                     /label="ctg32_5"
                     /locus_tag="ctg32_5"
                     /protein_end="64"
                     /protein_start="6"
                     /score="29.5"
                     /tool="antismash"
                     /translation="MQALRLDIAGELEAIYLYESHYLATDDPAAKAVLADIRDEEKAHM
                     GELITLMRHLDPK"
     CDS             6384..7103
                     /locus_tag="ctg32_6"
                     /transl_table=11
                     /translation="MEGMRPTVVRATMRQAGLVPRPATYVSRSFGVPGIKNTRNRISSN
                     RRASRSHLTSEIFSGGKNSLTTRMPKVRVSNRARPVPIALAARHHRVPSTVPNAYPAAS
                     SSGSPGRKASTTWAAFAATNATRPQIPMPSTHARKRSVSDTNAKASGPKRTQSAIKPAE
                     KASRATMNAVRFAICSCRSRAAAAAAPEAQGESCDEALGAMVRCSAVMSSMESRFYDAI
                     SLHQMLRVKYLLPINAA"
     CDS             complement(7118..8746)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 108.6; E-value: 7.1e-33)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg32_7"
                     /transl_table=11
                     /translation="MARVGRAADAGGGNDTSTGAARLVQLRERWRNASLKTSFMVYMLL
                     FLIAALVLSLTTSALFVGLQNEATADAYEVSGLYLYDKETDSLVAARSIEVTSDSRLAF
                     VQSARRGMQSIARADLPDSTAVTDASDYSFVYDFNYESSGDQEALEPAFGSEATLANLP
                     AYDAWARKRFDAWLAENPDSPYAALFPLDTAEGAATEGPLTSPIGYYLSTPASPSAWAL
                     SSLFGFLSFLMFPLWFGVCIFAAARRFFRMRLAPGLAVLDSAAAKIADQDLDFTVAHGR
                     EDELGRLAQSFETMRASLAESQKALWRTAEERKRLNAAFAHDLRTPLTILKGKIELLDT
                     RIKAGTASSEQLEASTASLSAQVERLERYVAAMSSLQKLEDREPERSDVAFGRIAELIE
                     DAGNGLARSNEARFSLFVSQRCACEQPSMRVDGSLVSEVAENLLANAFRYASKTASARL
                     DVRPTEHEGCEELVLIVDDDGPGFSCAALKNGCAPFFSETPSKERFGLGLNISSLLCDK
                     HGGSLTLENRPEGGARVTARFACQP"
     PFAM_domain     complement(7136..7444)
                     /aSDomain="HATPase_c"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02518.28"
                     /description="Histidine kinase-, DNA gyrase B-, and
                     HSP90-like ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_7_0010"
                     /evalue="4.30E-11"
                     /label="ctg32_7"
                     /locus_tag="ctg32_7"
                     /protein_end="537"
                     /protein_start="434"
                     /score="43.4"
                     /tool="antismash"
                     /translation="VSEVAENLLANAFRYASKTASARLDVRPTEHEGCEELVLIVDDDG
                     PGFSCAALKNGCAPFFSETPSKERFGLGLNISSLLCDKHGGSLTLENRPEGGARVTAR"
     PFAM_domain     complement(7607..7810)
                     /aSDomain="HisKA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00512.27"
                     /description="His Kinase A (phospho-acceptor) domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_7_0009"
                     /evalue="2.20E-08"
                     /label="ctg32_7"
                     /locus_tag="ctg32_7"
                     /protein_end="380"
                     /protein_start="312"
                     /score="34.1"
                     /tool="antismash"
                     /translation="RKRLNAAFAHDLRTPLTILKGKIELLDTRIKAGTASSEQLEASTA
                     SLSAQVERLERYVAAMSSLQKLE"
     PFAM_domain     complement(7850..7960)
                     /aSDomain="HAMP"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00672.27"
                     /description="HAMP domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_7_0008"
                     /evalue="9.60E-07"
                     /label="ctg32_7"
                     /locus_tag="ctg32_7"
                     /protein_end="299"
                     /protein_start="262"
                     /score="29.2"
                     /tool="antismash"
                     /translation="SAAAKIADQDLDFTVAHGREDELGRLAQSFETMRASL"
     CDS             complement(8734..9435)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 208.4; E-value: 1.7e-63)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="MSAGQKPTDVTTVLVVDDEPDIVELLEEYLSDQGFRVLTAKDGAT
                     ALKRAQQKPDLIVLDVGMPEMDGYTVCRRIREHLSCPILFLTARVEDVDALEGFEAGAD
                     DYVLKPFSLAVLGARIRAHLNREQRRQTKAEVRFDGNIVIDYSARTVSVAGSPVELTRR
                     EFDIVSFLSKHPGQVFERDRIHEHVGGWENESDPSVVTEHIRRIRKKLAKAGAENDPVE
                     TVWGMGYRWRA"
     PFAM_domain     complement(8746..8973)
                     /aSDomain="Trans_reg_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00486.30"
                     /description="Transcriptional regulatory protein, C
                     terminal"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_8_0012"
                     /evalue="5.60E-22"
                     /label="ctg32_8"
                     /locus_tag="ctg32_8"
                     /protein_end="230"
                     /protein_start="154"
                     /score="77.7"
                     /tool="antismash"
                     /translation="GSPVELTRREFDIVSFLSKHPGQVFERDRIHEHVGGWENESDPSV
                     VTEHIRRIRKKLAKAGAENDPVETVWGMGYR"
     PFAM_domain     complement(9076..9399)
                     /aSDomain="Response_reg"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00072.26"
                     /description="Response regulator receiver domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_8_0011"
                     /evalue="1.50E-29"
                     /label="ctg32_8"
                     /locus_tag="ctg32_8"
                     /protein_end="120"
                     /protein_start="12"
                     /score="102.5"
                     /tool="antismash"
                     /translation="VLVVDDEPDIVELLEEYLSDQGFRVLTAKDGATALKRAQQKPDLI
                     VLDVGMPEMDGYTVCRRIREHLSCPILFLTARVEDVDALEGFEAGADDYVLKPFSLAVL
                     GARI"
     CDS             complement(9526..9993)
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MLYDNVMVPFDGSESAVAALAEAARFAKEDPGLTLRIVQIIDTNK
                     LVINRLEAQNIVDSAVPEGMRKAFEEVTAEANRHLHRQIDGMLGGLMNKIVIELLEETH
                     PGSQIVSYAEECNCDLIVMGSRGLGAFRGILGSVSSHVLREAPIPVLVVKE"
     PFAM_domain     complement(9532..9987)
                     /aSDomain="Usp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00582.28"
                     /description="Universal stress protein family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg32_9_0013"
                     /evalue="1.20E-26"
                     /label="ctg32_9"
                     /locus_tag="ctg32_9"
                     /protein_end="154"
                     /protein_start="2"
                     /score="94.0"
                     /tool="antismash"
                     /translation="YDNVMVPFDGSESAVAALAEAARFAKEDPGLTLRIVQIIDTNKLV
                     INRLEAQNIVDSAVPEGMRKAFEEVTAEANRHLHRQIDGMLGGLMNKIVIELLEETHPG
                     SQIVSYAEECNCDLIVMGSRGLGAFRGILGSVSSHVLREAPIPVLVVK"
ORIGIN
        1 tccgggccga cctggaggag gcgcttctcg aggtcgcggc gtacaaggag ctgatgcgcg
       61 acccaaaagc cgcaggcccg gagagcctct cgaagaggcg gctcgtcggg ttaggagaga
      121 agctgagacg ggactccggg tgctccctgg cccggatctt gacgttcttg ggcatctcga
      181 agagcaccta ccactaccac cgggcgaggc tcgatagccc gtccggcatg ccggacgagg
      241 acttcgacga ggccgtggtc gaggcgttct cgaggaacgg ggggatctac ggctaccggc
      301 gcctcaaagc ggagctcgag ggcgagggcg tgcgcgcccc cgagcgcaag gtgcgcgagg
      361 cgatggccag gctcggcctc gtcgcccgct gctcgaggtc ggagaggaag tggagctcct
      421 acaagggcga gatctcggac gccccggaca acctgctcgt cggaagccgc gggcgccacg
      481 acttctcggc gggcgcgccc gacgaggtgt ggctcaccga catcaccgag atgaagggcc
      541 gcgacggcaa gctctacctg tccgtcatcg tcgactgctt cgacggcaag gccgtcgcct
      601 ggcgggcgtc gacgagcccg aacgcggagc tcgcggactc cacgctccgc gacgcgatcg
      661 cgacgctcga ggagggccgg cgcccgatcg tccactccga ccgcggcgcg cactaccgct
      721 ggaaggggtg gatcgcgctg tgcgaggagg cggggctcgt gcgctcgatg tcgcgcaagg
      781 ggcacagccc cgacaacgcg gcgtgcgagg gcttcttcgg ccgggcgaag gtggagctct
      841 tccattcgct cgttcgggcg ggggcttcgg tggccgagct gtccgaagcc gtggagaggt
      901 acatgcggtg gtacaatgac ggccgtctca aggcgttcaa gtcagatggc ggaagagcat
      961 cctacgagac catccgcgat cgccgcaaaa ggctcgggct ggcagcctga gcagtccaag
     1021 aatcctgccg cacccccaaa ctcgtccgtt ttgacagcgg gcccatgggt ttcggcgccg
     1081 cgcgccacgc ggcgcgcggg ctggcgttcg ccggcgccct cccgttggcc gccggtgcgg
     1141 tcttgttgcc cactactcct cgaacaaggc tatgacgtcg gctttcgagt gcgcgccgag
     1201 cttggcgtac aggtgacgaa catgggtctt caccgtgttc tcggaaagga acagctgctg
     1261 ctcgatttcg gcgcggcttt ttcgctgggc gatgagcccc atgatctcgg tttctcgggc
     1321 cgtgaggccg tatcgttccg ctagcgactc gcatcgcgcc atgaaccgtt cgcgcggacc
     1381 gggtacatgc agctgtccgt caagggttat tcccgatgcg ccccagtctc cgttcacgga
     1441 cttttcgctg gtccagacca gtgcgcatac taaaaccagc acgatgccgc ccagcgccaa
     1501 tccaacgagg aacgcctcgt tgaaaaacag gctgttctgc agcaggcatt ggcggatgcc
     1561 gattcctgcg aaaattccca actcgctcaa cgcgcgggca agggcgaaga gccgtagggt
     1621 gggaacctcg aagcgaaacg cgatgtttgc cagcatgagc agtacgaaca tggtgaacca
     1681 cacgtatgcc agcttgaggg aaaacgagac ggcgaatccc cattgcggat cggcgaaggg
     1741 aatcgccgcc agtgcgatga tggaaagggg caggccaacc tttgcaagga accgcacgtc
     1801 gatgcgatct ttcagcgtga gcgccatcac gatgatcacg atacctgcga gtccggtcgc
     1861 caccacgcgg tgaatggctc ccatccaggt ggcatcgggg atgaccgatc ctgcggtgcc
     1921 ggaaagaagt ccggcggccg tcatgatgcc cagcagcttc cagggaaggg ggtagcgcgt
     1981 gttcgccgag cgggcaggtt ccgttggaag gatgcgcaag ctcagcaggg cgcatgccaa
     2041 cgacgccaag ggaagcagcg ccgttgcggc gatagcgtac ggttcctgca tggtgctgac
     2101 tgcgaacgaa actacggcgg cggtgatgca cgagcctgcg ccgtacatga gcgtgcgcgt
     2161 agttcccatt tgactgtacg cttcagccca aagacaaaag agaaaggcgc ctccgatagc
     2221 cgttacggcc gatacggcaa acagaattgc cgctgcgctt cctgcgggga acaagaccag
     2281 tccctgaagc gccgtccctg ctgccgtgat gattacgaat gcagcgcttg cttttttatg
     2341 actgctgagg cgaccgatgc ggtttgaaaa aagggcgagc gccaaaaacg tgccaacgtc
     2401 gcctacgcgc atcccgtaat tgatggccgc aagagacgtg tcgggaaatc cgaagccagg
     2461 aaaaatgaag gttacatgcg tgcagcatag ccatgcgaca agcaacccca tgcccaaaaa
     2521 tcgcaggggg aacagcagtg cagcaaaaga atcttcctct tctgcctgat cttcgggaac
     2581 gatggctcgt acgacatcac ttggtttcac ggctcctcct tgtggttgcc atattgtacc
     2641 aggccgggtg cgtggcgtta cgaagagacg cgcccgcatc gtgaggatgc gggcgcgctg
     2701 cacgctgccg cagatgctgg gtatctggca agggcttttg ctgagcgctt ggtcaaacca
     2761 tgcgtcgagc gcgtctttgc ggcagtcgca tgcatgcatg cgtgccgtgc ttcgggaggg
     2821 ggtgagtgca ggggtgagct tggattcacc cccttgctgg acggttcacc cgcgacaaaa
     2881 cccaaggttg aacgcatgat ggcccaagag cccagagagg gcagccgatc agcttggcat
     2941 gcggcaccga cgcagcgctc aagctgacgg acacgtgaat tcttcggagg gagttcttat
     3001 gagcgagatt accaaaggcc tgtcgcgccg cagctttctg acgttgggag gcgtggctgc
     3061 actgggcgga gccgccgctc tggccggttg cgccccgcag gcgtcgagcg aatcgaagtc
     3121 ggagtccgca aagggcgacg acgccgctat gaagacggcc gaccagacga aagagtgcga
     3181 catcgccgta gttggcgcgg gcggagccgg catgtgggct gcggttgagg ccgtgcgcgc
     3241 cggcaagagc gtcgttgtta tcgaaaaggg cgcgaacgtg ggcgtggcga acggttcgct
     3301 ggccggcggg ccgttcaccg tcggctcgaa gctgcagcag gaagccggca tcgacttcac
     3361 ggttgaagag gcgttcaagc acatcatgga atacggtcac tggtccacga acgcggccgc
     3421 catcaaggcc gccgtggaaa tctccggcga gaccatcgac cagttcacca gcgacttcgg
     3481 cgtgcccacc ggcttgcgcc ccgacaacta cggtgccggt catgcttcgg tgcgcgccaa
     3541 cttccagtcc gatcccaagg actcgaagac gcagaccaag ggcgaggcgc gcatgaaacc
     3601 gcttcaggaa ttcgttgagt ccgaaggcgg cgagttcctg ttcaacactg ccggcaagcg
     3661 cctcatcatg gaaaacggcg catgcgtcgg cgtgcagtgc gaaggcgaag gcgtcatcga
     3721 cgtgaaggcc aagcaggtca tcgtggctac cggcggcttc ttgggcagcg ccgacatgat
     3781 gctggagaag ttcggcacgt tcgtgaaccc gctgggcaac atcctgtccg tgggcgaggg
     3841 catcgacatg gtgcaggctg cgggcggcca ggtgtccacg cagtggggta tcgcaggcaa
     3901 cgagttcgcc ggctccaacc agaaggccga cggcctgtac gatcgcaaga acgcagcgtt
     3961 cacggtgggc atttacggca cgctgttggt gaacaaccag ggccgtcgct tcagcaacga
     4021 gggcaagttc gcgaaccttc cgctggcgct gggcggagcc atctcgctgg tgggcgggaa
     4081 gtactacgcg gtggtcgacc agacgtacgt cgacggcttg aacgcgggca ccgatgcgtg
     4141 gacgttgtgc ggctccgacg ccgagaactg gcgcaccggc atgatgaccc tcaagggcaa
     4201 ggcgctcgag aacgttcagg cgaacttcga cgccgccgtt gacgcgggct gggccttcaa
     4261 ggcggattcg atcgaggcgc tgacagaggc cattgacgcc cctgatttga cgaagaccgt
     4321 tgaagcctac aacgctgcgt gcgctgcagg caaggacgac cagttctaca agccggcttg
     4381 cttccttcag ccggtggccg ccggtccgtt ctacgccatg cagtacgagc ccagcgcttg
     4441 ggtgaccatc ggcggcatcc gcacgaacga ccgcttgcag gctatcgacg ccgaaggcgc
     4501 ggccatcccc ggtctgtacg tggcgggcgc cgacaacggt acgctcatga gcgcgccgta
     4561 caccgactac gagggctact ccctcatgtg cgcgtactgc ggcggccgct tggctggcca
     4621 gtacgccgct gcggcgatcg acgcgtagca tttcggtttc cagagcgcgc agacccctcc
     4681 cttacgcgcc ctgctccgta gtttcggcgg cttgtgccgc tcgaaaagaa acggcccgca
     4741 ccttgtgaag cgtgcgggcc gtttcgcgtt tactcgaaca cgacgattgc cgcggggtct
     4801 ttgatgcgca gcgcggctgt ttccatgata cggaagtgat ggttgaaatc cgtcagctct
     4861 gcgtacccga ccgaaagatc aaggccgagc gccaagtcga ggtactcggg ctccgcgcac
     4921 accagcacgg ccttgccttg gtcgattgcg ctggtcatgt agacgttgtc gccgatcagc
     4981 ttcttgatgc ggtcgatctc cagcataccg gtgttgggtt ggaggcgctg caaggccagg
     5041 aacagatccg gtgccacggc gagcgcgtag cggcccaggt acccggtctt ggcaagctgg
     5101 gagacggcgg ctgctacgtc ggaaaacccg ttctcgccct tattccaatc ggcgcgcttc
     5161 atcttgttcg cgcccttggc ggtgagcagg ccttcggtcc ccagcagctg gctgccgttc
     5221 agcaccaggc cgtcctcgcg ccgcgcagcc ttcttggctg ccgtaacggc cggagctaga
     5281 tcaagcggca tgcccgtttg ggtggccagt tcaagatcgc gcccgagcag ggtgaagtct
     5341 tcgtacagca tgggcagctc aagttgcgtg cgcccaacga tgcggccgat gccgtcttcg
     5401 agcacctctt ctttggctac gctgtctacg gcgacggtag ttgctccggg gccgagcggt
     5461 ccgtaggttt tcaggaagcg ccgtgcggtc aattgctggc gcgccgtgct tatgacggcg
     5521 ttgtcgattc ggttccaaag ctcagccgaa agatcggccg attcgcgagc gaggtaatcc
     5581 atatcgaact cctttcgatt tgggaaagcg tgcggccgcg cacaaggcgg aaagcgaagc
     5641 cgactgtctt gccgggccgt cggcggaagg gcgggtccct tccgcgcagg tggcaaggtt
     5701 aggaaagatc gcccaccgta ggggctgctg cgggttcggc aggcgccggc gcaatgtgcc
     5761 cgtcggtctt gatgcccagg tcttccagca tttcctgcac ttctccctct ccgtccagga
     5821 agaactcggt ttccttggga tccaggtggc gcatcagcgt gatgagttcg cccatgtgcg
     5881 ccttttcctc atcgcggata tcggccaaca cggcttttgc cgcggggtcg tcggtggcca
     5941 gatagtggga ttcgtacagg taaatggctt ccagctctcc tgcgatgtca aggcgcagcg
     6001 cctgcatgag ctcggcgttg gtcatcttgc ggtcgacgtt gccggcaaac ggattcgcga
     6061 aactaggcat agggggcctc tctctccttg tgtcgttccg atgggctggg ccggtgcggt
     6121 gctgcggttg cggcgtgctc gtcggtgacg gcttcggtta cgttctttcg cacatcatac
     6181 gctcttgggt cggagaaaga ggttacgaat cggtagttat caataactat tcttaataaa
     6241 tacactattg cgattcaata cgggacatac gccggtagac aagcacgcct gctcccgcca
     6301 gcgctacggt gatggcggca acgatggctg ctgcggtgta gttgccgctg cccagggcgc
     6361 ctgcaacaag ggtcgaggag acgatggaag ggatgcggcc cacggtggtc agggcgacga
     6421 tgcgccaagc ggggcttgtc cctaggccgg caacgtacgt gagcaggtct ttcggggttc
     6481 cgggaatcaa gaacaccaga aacaggatca gctcgaaccg tcgtgcgtcg cgcagccatt
     6541 tgacttccga aattttctcg ggaggaaaga acagcctcac gacgcgcatg ccgaaggtgc
     6601 gggtgagcaa cagagcaagg ccggtgccga tcgcgcttgc cgccaggcac catagggtgc
     6661 cctcgaccgt gccgaacgcg tatccggctg ccagctcaag cggctcgccg gggaggaagg
     6721 ccagtaccac ctgggcggcg ttcgctgcga cgaacgcgac gcgcccccag attcccatgc
     6781 cttccaccca tgcgcggaag cgctcggtat ccgatacgaa cgccaaagct tcggggccga
     6841 agcgaacgca gagcgcaatc aagcctgcgg agaaggccag cagggcaacg atgaacgccg
     6901 tgcgctttgc catctgcagc tgccgctcgc gcgcggcagc tgcagcggcg cctgaggcgc
     6961 agggagaaag ctgcgatgag gcgcttggcg cgatggtccg atgcagcgcg gtgatgtcgt
     7021 ccatggagtc tcgtttctat gatgcgatca gcttgcatca aatgctacga gtcaaatatc
     7081 tactcccgat caacgccgcg taaactatag gtcgagttca aggctggcat gcgaaccgcg
     7141 ccgtcacccg cgcgcctcct tcggggcgat tttcgagcgt gagcgatccg ccgtgcttgt
     7201 cgcatagcag gctgctgatg ttgagtccca ggccaaagcg ctctttcgac ggagtctcgc
     7261 tgaagaacgg cgcgcaaccg ttcttcaggg ccgcgcatga gaagcccggt ccgtcgtcgt
     7321 ccacgatgag cacgagttct tcacagcctt cgtgctctgt cggccggacg tccaagcgcg
     7381 cggacgcggt tttcgacgcg taacggaagg cgttcgccag aagattctcc gccacttcgc
     7441 ttacgagcga gccgtcaacg cgcatcgaag gctgctcgca tgcgcatcgc tgactgacga
     7501 acagggagaa gcgtgcctcg ttcgagcgag ccaggccgtt gccggcatct tcgatcagtt
     7561 cggctatgcg gccgaacgcg acgtcggacc gttcgggttc gcgatcttcc agcttctgga
     7621 ggctgctcat ggccgcgacg tagcgttcga gccgttcaac ctgggccgaa agcgacgccg
     7681 tcgaggcttc cagctgctcg gaagacgccg ttcccgcttt gatgcgcgtg tccaaaagct
     7741 cgatctttcc cttcaagatg gtgagcggcg tgcgcagatc gtgcgcgaag gccgcattga
     7801 ggcgctttct ttcctcggct gtgcgccaca gggctttttg cgattccgcc agagaagcgc
     7861 gcatggtttc aaacgactga gccagtcttc ccagttcgtc ttcgcggccg tgcgccaccg
     7921 tgaaatcgag gtcctgatcg gcgattttgg ctgccgcgct atcgagcacg gcaaggcccg
     7981 gagcaagccg catgcgaaaa aagcgtcgtg cggcggcgaa tatgcacacg ccgaaccaca
     8041 aggggaacat gagaaacgac aagaacccga acagggagga aagggcccat gcgcttggcg
     8101 atgccggcgt gctgaggtag tagccaatgg gcgacgtcag gggtccttcc gttgcggcgc
     8161 cttcagccgt gtccaggggg aagagcgcgg cgtagggact gtcggggttc tcggccagcc
     8221 aggcgtcgaa ccgcttgcgc gcccatgcgt cgtaggcggg taggttcgcg agcgtcgctt
     8281 cggagccgaa ggcaggctcg agcgcttcct gatcgccgct ggattcgtag ttgaagtcgt
     8341 agacgaacga gtagtcgctc gcgtccgtta cggcggtgct gtcgggcagg tcggcccgtg
     8401 cgatcgactg catgccgcgg cgcgcgcttt gcacgaacgc caggcggctg tcggacgtta
     8461 cttcgatcga acgcgctgcc accagggagt cggtttcctt gtcgtagagg tagagccccg
     8521 atacttcgta ggcatcggcg gtcgcttcgt tttgcaagcc gacgaacagc gccgacgttg
     8581 ttagggacag cacgagggcc gcaatcagga acagcagcat gtacaccatg aacgacgtct
     8641 tgagcgacgc gttgcgccag cgttccctca gttgcacgag gcgggccgca cccgtggacg
     8701 tgtcgttgcc gccgcccgcg tctgcggccc ggcctacgcg cgccatcggt accccattcc
     8761 ccacacggtt tcaacagggt cgttttccgc tccggccttc gccagcttct tgcggatgcg
     8821 tcggatatgc tcggtgacga ccgacgggtc gctctcgttc tcccagccgc cgacgtgttc
     8881 gtggatccga tcgcgctcaa acacttgacc agggtgtttg gaaaggaatg aaacaatgtc
     8941 gaactcgcgt cgcgtcaact cgaccgggct gcccgcaacg ctgacggtgc gggcgctgta
     9001 gtcgatgacg atgttgccgt cgaaacgcac ttcggctttc gtttggcgtc gctgttcccg
     9061 attgaggtgc gcgcggatac gggcgcccag cactgccagc gagaaaggct tcagcacgta
     9121 gtcgtcggca cccgcctcga atccttcgag agcgtcgacg tcttccacgc gagccgtcag
     9181 gaacaggata gggcagctca ggtgctcgcg aatgcgtcgg cataccgtgt agccgtccat
     9241 ttccggcatg ccgacgtcaa gcacgatgag gtcgggcttt tgctgagccc gcttgagcgc
     9301 cgttgctccg tctttggcgg tgaggacgcg aaatccctgg tcgctcagat attcttccaa
     9361 tagttcgacg atgtcgggct cgtcgtccac gacaagcacg gtggtgacgt cggtaggttt
     9421 ctgtcctgcg ctcatacggt tctttcgctt tgatgggcat gtacgcggcg aagcatagca
     9481 cgggaatccc aacaaacgat caacgcgcgg ccgctgcgcg cttcgctatt ccttgaccac
     9541 cagcacgggg atgggggcct cgcgcaggac gtggctgctc acgctgccca ggatcccgcg
     9601 aaacgcgcca aggccgcgcg atcccatgac gatgaggtcg cagttgcatt cttccgcgta
     9661 cgatacgatt tgcgagccag ggtgggtttc ttcaagaagc tcgatgacga ttttgttcat
     9721 cagcccgccc agcatgccgt cgatttggcg gtgcaggtgc ctgttcgctt cggccgtgac
     9781 ctcttcgaag gctttgcgca tgccttcggg gacggcggaa tctacgatgt tttgcgcttc
     9841 cagcctattg atgaccagct tgttcgtgtc gatgatctgc acgatgcgca gggtgaggcc
     9901 ggggtcttcc ttggcgaagc gcgccgcttc ggccaatgcg gctacggctg attccgagcc
     9961 gtcaaaggga accatgacgt tgtcgtacag cataaggggc tcctttcttt cgcgcgattg
    10021 catcgttgcg atgctgttgg gtcgcgaagg ttctctcagt atagcagtcc gccgggggcg
    10081 ccttcgtcgg gccgcttccc gttgggtcat cgttcggcat tgttcggcgt gacgaagatc
    10141 gtctcctttc ggcctgttgt ttcccctctt cggcatggat gccgatccgg cctggcgcaa
    10201 ccccgttttc agagtgcgaa gtagtacgat gcaagcaggt acgcctggtc gtacttccgg
    10261 gcaaggccga ggagcttgcg cttcaccgat tccgccgttg cctcgccgcg ctggaaccgc
    10321 tccattgcgt cgaggaacga agcgcgctct ttgtcggtgg acagatccga cacgtagccc
    10381 cagacgtgct gcgccgcatt ggcgaacgat ccggtggagg cgggaattgc cagggattgc
    10441 tccaccagcc ggtagaacgg gacggccgga cggctttgct tgtctttgag aagcgtgcga
    10501 atgcgctggt aggacgcctg gtcatgttcg agcaccacgt atttgtagcg cgcccattcc
    10561 tgctcgagcc ttgttatggg gc
//
