LOCUS       c00008_NZ_JACH..       10396 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_JACHZF010000008.1 Halomonas campaniensis strain 5AG Ga0075189_08,
            whole genome shotgun sequence.
ACCESSION   c00008_NZ_JACH..
VERSION     c00008_NZ_JACH..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:28:53
            Original ID  :: NZ_JACHZF010000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 54150
            Orig. end    :: 64546
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10396
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[59150:59546](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5396)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     cand_cluster    1..10396
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10396
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     CDS             2462..3697
                     /locus_tag="ctg8_59"
                     /transl_table=11
                     /translation="MSTLYKKFPYSRLAALTGGAILPLVGAALIGAATPAEAFLVDRAE
                     AQQGQGQGQGAGRDPLNIGRGKGNGFGAGGEGRSIESDIFRDAASGRPEDRGQGGGGDR
                     GGRPDGAGSGGGPDSGKGGDYGDIVVILRNDDGTPLLDENGNVQPCLDAACEEVIQLVQ
                     EEDGKFEIPEEYIDQVIPVEFGRLNVARSPSSVTDHSLAELLSKMDGVEISADTLAEMT
                     DTSGRLITPDGATIDSPLENLAFYVALLEATNQEPVDGFYTISITTNPRGDGQPDAYSM
                     TVDADILLTLAASALAASSDKYGDLTIDEVMGISGFLGVADELSALVGSDSYSYDRESL
                     YGGIEVTVLREVEIDGTIYYQPTSVVLLDEVVFNTVPTIEDNGYGIDTFTQQADDAVQV
                     LEYVHDFGLESE"
     misc_feature    2471..2473
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             3770..4231
                     /locus_tag="ctg8_60"
                     /transl_table=11
                     /translation="MTARHSPALRRLLVAGLLPLALAVGSAQGAGFSASPPLPDPGLLL
                     ASSDHADGHDSHGGSDRGQRGGQGQGKRLGKGAGTGEARGGHSVTDDIFRDEGFSRGNP
                     DRGGGPPEGRGEHEDGDDHDHEEGDDHDSGPPEGRGGGHESGEEHDHES"
     CDS             4350..4943
                     /locus_tag="ctg8_61"
                     /transl_table=11
                     /translation="MYRKMAWWLALVLLLAGCSSVDIDRYADTTPRLDIGEYFAGQTRA
                     WGMVQDYRGEVQRRFTVEIEGDYDGDTLTLDEHFVYDDGETDRRVWTFQRQDDGRWVGR
                     ANDVEGPVEARQSGHAFNMTYRLPVEVSGREITFTLDDWMFLQPDDRLINRTAMKKFGI
                     TLAEITIVFERLDGDADSPDADTLSDTNADAPGT"
     PFAM_domain     4386..4871
                     /aSDomain="DUF3833"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12915.9"
                     /description="Protein of unknown function (DUF3833)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_61_0001"
                     /evalue="3.40E-63"
                     /label="ctg8_61"
                     /locus_tag="ctg8_61"
                     /protein_end="174"
                     /protein_start="12"
                     /score="212.2"
                     /tool="antismash"
                     /translation="LLLAGCSSVDIDRYADTTPRLDIGEYFAGQTRAWGMVQDYRGEVQ
                     RRFTVEIEGDYDGDTLTLDEHFVYDDGETDRRVWTFQRQDDGRWVGRANDVEGPVEARQ
                     SGHAFNMTYRLPVEVSGREITFTLDDWMFLQPDDRLINRTAMKKFGITLAEITIVFER"
     CDS             complement(5001..5396)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_62"
                     /sec_met_domain="ectoine_synt (E-value: 4.6e-42, bitscore:
                     136.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRNLEECRKTDRLVKAENGNWDSTRLSLADDGGNCSFHITRIY
                     EGTETHIHYKHHFEAVYCIEGEGEVETLADGKIWPIKPGDIYILDQHDEHLLRARKTMH
                     LACVFTPGLTGKEVHREDGSYAPADEG"
     PFAM_domain     complement(5016..5396)
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06339.14"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_62_0002"
                     /evalue="9.40E-54"
                     /label="ctg8_62"
                     /locus_tag="ctg8_62"
                     /protein_end="127"
                     /protein_start="0"
                     /score="181.1"
                     /tool="antismash"
                     /translation="MIVRNLEECRKTDRLVKAENGNWDSTRLSLADDGGNCSFHITRIY
                     EGTETHIHYKHHFEAVYCIEGEGEVETLADGKIWPIKPGDIYILDQHDEHLLRARKTMH
                     LACVFTPGLTGKEVHREDGSYAP"
     CDS             complement(5486..6751)
                     /NRPS_PKS="Domain: Aminotran_3 (23-362). E-value: 1.1e-73.
                     Score: 240.0. Matches aSDomain:
                     nrpspksdomains_ctg8_63_Aminotran_3.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 354.8;
                     E-value: 1e-107)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_63"
                     /sec_met_domain="Aminotran_3 (E-value: 1.1e-77, bitscore:
                     254.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTQILERMESDVRTYSRSFPVVFTKATNARLTDENGREYIDFLA
                     GAGTLNYGHNNPKIKQALLDYLAEDNIIHGLDFWTAAKRDYLATLEELILKPRGLDYKV
                     QFPGPTGTNAVEAAIRLARNAKGRHNIVTFTNGFHGVTMGALATTGNRKFREATGGVPT
                     VGGSFLPYDGYLGDGTDTLDYFEKLLSDKSGGLDVPAGVIVETVQGEGGINACSTEWLK
                     RLEQICRAHDILLIVDDIQAGCGRTGKFFSFEHAGVVPDIVTNSKSLSGLGLPFAQVLM
                     RPELDAWKPGQYNGTFRGFALAFTTAAAALRHYWGNDEFERDVQRKGEIVAERFAGIAA
                     WIREQGIEASERGRGLMRGIDVGTGEIADKITHQAFENGLVIETSGQDGEVVKCLCPLT
                     IPDADLHKGLDILEASAKQALS"
     aSDomain        complement(5492..6736)
                     /aSDomain="TIGR00709"
                     /aSTool="tigrfam"
                     /description="dat: 2,4-diaminobutyrate 4-transaminase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg8_63_0002"
                     /evalue="5.10E-134"
                     /identifier="TIGR00709"
                     /label="ctg8_63"
                     /locus_tag="ctg8_63"
                     /protein_end="420"
                     /protein_start="5"
                     /score="445.1"
                     /tool="antismash"
                     /translation="LERMESDVRTYSRSFPVVFTKATNARLTDENGREYIDFLAGAGTL
                     NYGHNNPKIKQALLDYLAEDNIIHGLDFWTAAKRDYLATLEELILKPRGLDYKVQFPGP
                     TGTNAVEAAIRLARNAKGRHNIVTFTNGFHGVTMGALATTGNRKFREATGGVPTVGGSF
                     LPYDGYLGDGTDTLDYFEKLLSDKSGGLDVPAGVIVETVQGEGGINACSTEWLKRLEQI
                     CRAHDILLIVDDIQAGCGRTGKFFSFEHAGVVPDIVTNSKSLSGLGLPFAQVLMRPELD
                     AWKPGQYNGTFRGFALAFTTAAAALRHYWGNDEFERDVQRKGEIVAERFAGIAAWIREQ
                     GIEASERGRGLMRGIDVGTGEIADKITHQAFENGLVIETSGQDGEVVKCLCPLTIPDAD
                     LHKGLDILEASAKQAL"
     aSDomain        complement(5501..6742)
                     /aSDomain="TIGR02407"
                     /aSTool="tigrfam"
                     /description="ectoine_ectB: diaminobutyrate--2-oxoglutarate
                     aminotransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg8_63_0001"
                     /evalue="3.70E-193"
                     /identifier="TIGR02407"
                     /label="ctg8_63"
                     /locus_tag="ctg8_63"
                     /protein_end="417"
                     /protein_start="3"
                     /score="639.7"
                     /tool="antismash"
                     /translation="QILERMESDVRTYSRSFPVVFTKATNARLTDENGREYIDFLAGAG
                     TLNYGHNNPKIKQALLDYLAEDNIIHGLDFWTAAKRDYLATLEELILKPRGLDYKVQFP
                     GPTGTNAVEAAIRLARNAKGRHNIVTFTNGFHGVTMGALATTGNRKFREATGGVPTVGG
                     SFLPYDGYLGDGTDTLDYFEKLLSDKSGGLDVPAGVIVETVQGEGGINACSTEWLKRLE
                     QICRAHDILLIVDDIQAGCGRTGKFFSFEHAGVVPDIVTNSKSLSGLGLPFAQVLMRPE
                     LDAWKPGQYNGTFRGFALAFTTAAAALRHYWGNDEFERDVQRKGEIVAERFAGIAAWIR
                     EQGIEASERGRGLMRGIDVGTGEIADKITHQAFENGLVIETSGQDGEVVKCLCPLTIPD
                     ADLHKGLDILEASAK"
     PFAM_domain     complement(5513..6700)
                     /aSDomain="Aminotran_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00202.23"
                     /description="Aminotransferase class-III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_63_0003"
                     /evalue="1.30E-75"
                     /label="ctg8_63"
                     /locus_tag="ctg8_63"
                     /protein_end="413"
                     /protein_start="17"
                     /score="254.7"
                     /tool="antismash"
                     /translation="RSFPVVFTKATNARLTDENGREYIDFLAGAGTLNYGHNNPKIKQA
                     LLDYLAEDNIIHGLDFWTAAKRDYLATLEELILKPRGLDYKVQFPGPTGTNAVEAAIRL
                     ARNAKGRHNIVTFTNGFHGVTMGALATTGNRKFREATGGVPTVGGSFLPYDGYLGDGTD
                     TLDYFEKLLSDKSGGLDVPAGVIVETVQGEGGINACSTEWLKRLEQICRAHDILLIVDD
                     IQAGCGRTGKFFSFEHAGVVPDIVTNSKSLSGLGLPFAQVLMRPELDAWKPGQYNGTFR
                     GFALAFTTAAAALRHYWGNDEFERDVQRKGEIVAERFAGIAAWIREQGIEASERGRGLM
                     RGIDVGTGEIADKITHQAFENGLVIETSGQDGEVVKCLCPLTIPDADLHKGLDILE"
     aSDomain        complement(5666..6682)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg8_63_Aminotran_3.1"
                     /evalue="1.10E-73"
                     /label="ctg8_63_Aminotran_3.1"
                     /locus_tag="ctg8_63"
                     /protein_end="362"
                     /protein_start="23"
                     /score="240.0"
                     /tool="antismash"
                     /translation="FTKATNARLTDENGREYIDFLAGAGTLNYGHNNPKIKQALLDYLA
                     EDNIIHGLDFWTAAKRDYLATLEELILKPRGLDYKVQFPGPTGTNAVEAAIRLARNAKG
                     RHNIVTFTNGFHGVTMGALATTGNRKFREATGGVPTVGGSFLPYDGYLGDGTDTLDYFE
                     KLLSDKSGGLDVPAGVIVETVQGEGGINACSTEWLKRLEQICRAHDILLIVDDIQAGCG
                     RTGKFFSFEHAGVVPDIVTNSKSLSGLGLPFAQVLMRPELDAWKPGQYNGTFRGFALAF
                     TTAAAALRHYWGNDEFERDVQRKGEIVAERFAGIAAWIREQGIEASERGRGLMRGIDV"
     CDS             complement(6836..7411)
                     /locus_tag="ctg8_64"
                     /transl_table=11
                     /translation="MTTTEPFTPSADLARPTVADAVVGFDAMPLFIRKPNPDDGWGIYE
                     LVKSCPPLDVNSAYAYLLLATQFRDTCAVATNEEGEIVGFVSGYVKSNAPDTYFLWQVA
                     VGEKARGTGLARRLVEAVMSRPELAEVHHLETTITPDNQASWGLFRRLADRWQAPLNSR
                     EYFSTDQLGGEHDPENLVRIGPFQTDRI"
     aSDomain        complement(6851..7318)
                     /aSDomain="TIGR02406"
                     /aSTool="tigrfam"
                     /description="ectoine_EctA: diaminobutyrate
                     acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg8_64_0003"
                     /evalue="2.00E-68"
                     /identifier="TIGR02406"
                     /label="ctg8_64"
                     /locus_tag="ctg8_64"
                     /protein_end="187"
                     /protein_start="31"
                     /score="227.3"
                     /tool="antismash"
                     /translation="IRKPNPDDGWGIYELVKSCPPLDVNSAYAYLLLATQFRDTCAVAT
                     NEEGEIVGFVSGYVKSNAPDTYFLWQVAVGEKARGTGLARRLVEAVMSRPELAEVHHLE
                     TTITPDNQASWGLFRRLADRWQAPLNSREYFSTDQLGGEHDPENLVRIGPFQ"
     PFAM_domain     complement(6956..7210)
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_64_0004"
                     /evalue="2.40E-12"
                     /label="ctg8_64"
                     /locus_tag="ctg8_64"
                     /protein_end="152"
                     /protein_start="67"
                     /score="47.2"
                     /tool="antismash"
                     /translation="FRDTCAVATNEEGEIVGFVSGYVKSNAPDTYFLWQVAVGEKARGT
                     GLARRLVEAVMSRPELAEVHHLETTITPDNQASWGLFRRL"
     CDS             complement(7688..9067)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 437.6; E-value: 7.2e-133)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_65"
                     /transl_table=11
                     /translation="VSENLAPQHDWDLFVIGAGSGGVRAARTAAASGARVAVAEDRYLG
                     GTCVNVGCVPKKLYSYAAHFHDAFEDAAGFGWQLAEAPEFDWATLRDNKIGEIKRLNGI
                     YGRLLEGAGVQLIHGRARVVDPHTVEVAGETHTAAKILVAVGGWPWVPDFPGSELALTS
                     NEVFDLDTFPERFLVLGGGYIAVEFASIFNGLGSETHLVYRGDLFLRGFDREVREFTRD
                     QMAAKGVNLHFEENIAAIERVEGGLAVTLTSGERHEVDAVLAATGRRPHLAGLGLEALG
                     LELDDGGYLRVNDRFETSLPSILALGDVTGGPELTPVALAEAMHMVQHHFGETPPGSPL
                     DYRNIATAVFCHPNIGTVGLSEEAAREQCGEIRVYTADFRPMKHTLSGSSERCLMKLIV
                     DDASDVVVGAHMVGEEAGEVIQGIAIAVRAGLTKAAFDATVGIHPTGAEEFVTMRSPTR
                     R"
     PFAM_domain     complement(7709..8035)
                     /aSDomain="Pyr_redox_dim"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02852.24"
                     /description="Pyridine nucleotide-disulphide
                     oxidoreductase, dimerisation domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_65_0006"
                     /evalue="1.30E-33"
                     /label="ctg8_65"
                     /locus_tag="ctg8_65"
                     /protein_end="453"
                     /protein_start="344"
                     /score="115.6"
                     /tool="antismash"
                     /translation="IATAVFCHPNIGTVGLSEEAAREQCGEIRVYTADFRPMKHTLSGS
                     SERCLMKLIVDDASDVVVGAHMVGEEAGEVIQGIAIAVRAGLTKAAFDATVGIHPTGAE
                     EFVTM"
     PFAM_domain     complement(8099..9034)
                     /aSDomain="Pyr_redox_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07992.16"
                     /description="Pyridine nucleotide-disulphide
                     oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_65_0005"
                     /evalue="1.90E-63"
                     /label="ctg8_65"
                     /locus_tag="ctg8_65"
                     /protein_end="323"
                     /protein_start="11"
                     /score="214.5"
                     /tool="antismash"
                     /translation="DLFVIGAGSGGVRAARTAAASGARVAVAEDRYLGGTCVNVGCVPK
                     KLYSYAAHFHDAFEDAAGFGWQLAEAPEFDWATLRDNKIGEIKRLNGIYGRLLEGAGVQ
                     LIHGRARVVDPHTVEVAGETHTAAKILVAVGGWPWVPDFPGSELALTSNEVFDLDTFPE
                     RFLVLGGGYIAVEFASIFNGLGSETHLVYRGDLFLRGFDREVREFTRDQMAAKGVNLHF
                     EENIAAIERVEGGLAVTLTSGERHEVDAVLAATGRRPHLAGLGLEALGLELDDGGYLRV
                     NDRFETSLPSILALGDVTGGPELTPVALAEA"
     CDS             9234..9881
                     /locus_tag="ctg8_66"
                     /transl_table=11
                     /translation="MNQEIEGLLDNNRAWAARVSQDDPDFFARLSRQQNPAYLWIGCSD
                     SRVPANQIISLPPGEVFVHRNVANLVHPNDLNALSVLQYAVEVLGVRHIMVVGHYGCGG
                     VRAAVSGGDNGMVDIWLHSVRELYSRHRASLSTLPLDEQVDRMCELNARDQVMNLCRTK
                     IVQHAWQRGQELAVHGWVYGLADGRVKDLDCTVSGLDQVDTLYRIERLTPAG"
     PFAM_domain     9345..9800
                     /aSDomain="Pro_CA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00484.21"
                     /description="Carbonic anhydrase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_66_0007"
                     /evalue="1.20E-49"
                     /label="ctg8_66"
                     /locus_tag="ctg8_66"
                     /protein_end="189"
                     /protein_start="37"
                     /score="168.7"
                     /tool="antismash"
                     /translation="YLWIGCSDSRVPANQIISLPPGEVFVHRNVANLVHPNDLNALSVL
                     QYAVEVLGVRHIMVVGHYGCGGVRAAVSGGDNGMVDIWLHSVRELYSRHRASLSTLPLD
                     EQVDRMCELNARDQVMNLCRTKIVQHAWQRGQELAVHGWVYGLADGRV"
     CDS             complement(9885..10373)
                     /locus_tag="ctg8_67"
                     /transl_table=11
                     /translation="MLTRPLFVLLLAGLPMTPLLAEPAADAAAANGSAPAFEDPRQAVT
                     WRREELKEIERLVRQLRFDLVNNRDARGAAPRLEELAERASGDHLRPAFIEGSHGRGSE
                     ARARIWEEWEAFSEGFDALEARVEALRAAAEAEDYAAATRELSDLSLTCRSCHRRYRY"
     PFAM_domain     complement(9891..10250)
                     /aSDomain="Cytochrom_C_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01322.22"
                     /description="Cytochrome C'"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg8_67_0008"
                     /evalue="3.00E-18"
                     /label="ctg8_67"
                     /locus_tag="ctg8_67"
                     /protein_end="161"
                     /protein_start="41"
                     /score="67.0"
                     /tool="antismash"
                     /translation="QAVTWRREELKEIERLVRQLRFDLVNNRDARGAAPRLEELAERAS
                     GDHLRPAFIEGSHGRGSEARARIWEEWEAFSEGFDALEARVEALRAAAEAEDYAAATRE
                     LSDLSLTCRSCHRRYR"
     misc_feature    complement(10356..10358)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gaccctcgtc tcgccctttg ccgagctggt cggcagcggc gagcgtcacg aggtacgcct
       61 gcgcggcgat gcccagcgcg gcaagtacca cgagttcggc agcgagaact acaccgactg
      121 gcggctggca agtgaaggcc gcttcgccta tagccaggcc ggcagcctgt tcggcggcgt
      181 ctccctggcg cgcggccacg aggagcgctc ctcgccggat gacgtcaatg gcgaggagcc
      241 gacccgctat gatcgcgtcg gcgcctttgt cggggtcaac cacaccttcg gccgcatcac
      301 cagccgcgtg ggcggcacct gggagtcgct ggacttcgat aacgtgccgg ctgccggcgg
      361 caccaccatc ctccaggacg accgggatcg ccagatgacc accatcggcg gacgtttcgg
      421 ctaccgcctc tccgaccgcc tggagccctt cgtccaggcg gcagtggatg tgcgcgacta
      481 cgacgacccg ggcgccatcg atcgcgattc cgagggctac aatgccggcg cggggctgat
      541 ctaccgcccc cgcaccgacc tccacgccga gctcatgggc ggctggatgg agcaggacta
      601 cgacgacccg ggcctggatg acatcagcac cttcgacgcc ggggccgagc tgcgctggca
      661 gccggagggc ttacccaacc gcctcatcgc ccggctggat cgcaccatcg aggagaccac
      721 catcgagggc gcctcgggga acgttcgcac cggcgtcagc gcgcagctca ccaccgccat
      781 ccgccccgac ctgacgctca gcgcccgggc cagctacagc gaccacgatt accggggcac
      841 cgcccgcaac gacaacctgc tggggctggg catgggcctg cgccactacc tcaacccgca
      901 cctcttcgtg ggcgtggatt acgacttcct gcagcgcgac tccagcgagc ccgccgagga
      961 cttcgacaac aaccgcctga tggtcagcct ggggacccag ctggagcgcg gctacgagga
     1021 agccgcgcta ctggccgcgg cacgccatac cgacaccctg ggcggcttct atctcggcct
     1081 gcagggcggg ctcggcgagg tgggcaccgc ccaggccggc ccccgggcca ccgcccaggc
     1141 cggcccccgg gccaccggcc agaacggcag cctgcgggcc gatttccgcg ataccggcga
     1201 gacgctgggg ctgttcggcg gctacgcgct gaccttcgac gactggcggc tggccctgga
     1261 gctcgaatcg gaccagaccg gtgccggctg ggagcatgtt cgcagcggcg atggccgggc
     1321 cttctcggtg gagaagcagc gcgacgtcgg gctgggcctg cgcgtcgacc ggctgctggc
     1381 cggcggcaat gccgtctacg gccgcttcgg cctggtgcgg ggccgctttg acgcacgcta
     1441 cgccgagggc ggcgagaacc ttcaggacga gcagtggcac gacggtcggc ggatcggcgg
     1501 cggcctcgag gtcccgctgg ccaccaccct gggcctgcgc atggactaca gctacaccaa
     1561 ctacgacgac atcgacatcg gcacgggaga cgcccgcgac gacttcacct tcgaggagag
     1621 cctgatgcgc ctcgggctcg cctggcaccc ctggcgccag gccagcgaac gggccccggt
     1681 cgcaccggcc gcccatgacg gcttctacct gggcgcccac acgggctacg gcagcctggt
     1741 caccgacctg cgcggcccgc gcaccgcgcc caccgagctg gccgccgagt tcggcgacag
     1801 cggcggcctg gcgggcctgc atgccggcta cggcaggacc ttcggccgga tctacctggg
     1861 cggcgaagtc gatgccgagg tcagcgacat cacctggaac cacgagcgcc tgcccaatgg
     1921 ccgcacctat tcggtggacc gggagtcgag cctgggcctg gcgctgcgtg ccggctatgt
     1981 catcgacagc ggcgccctcc tctacctgct ggccggctcg gcctggaccg acttcgagac
     2041 ccgctacgcc cgtggccagc agcggatcca tctggacgag accgagcagg gctggcgctt
     2101 cggcggcggc ctcgaggtgc ccgtcggcga tgacctgcac ctgcgcatgg agctgaccca
     2161 gacccgttat gacgacgtcg aggtcgacta cggcaccggg gtggatcggc tggagagcga
     2221 ggagcgactg atgcggctgg ggctgagcta ccggttctga cagggcctgg acagcggcgc
     2281 ctgtgacccg gtacggccga ccaggcgcct gcggtcaaat gccgcatggt gatattgata
     2341 tatgtcaacg cgagaactca ccggcaggac tatctttaga atgcaggcgc ataaacgatg
     2401 atggctctgc ccgtttcaac atgaccaagc acgtgaccat ggcgtcactc aggggtttat
     2461 catgagtacc ttatacaaga agttccccta ctcccgtctg gccgccctca cggggggagc
     2521 catcctgccg ctggtcgggg ccgcgctgat cggcgccgcc accccggccg aggcgtttct
     2581 cgtcgaccgc gccgaggccc agcagggtca ggggcaaggc cagggagccg gacgcgaccc
     2641 gctcaatatc ggccgcggca agggcaacgg gttcggcgcc ggcggcgagg gccgctcgat
     2701 cgagtccgac atcttccgtg atgccgcatc cggccgaccc gaggacagag gccagggagg
     2761 cggcggagat cgcggcggca ggcccgacgg tgccggcagc ggtggcggcc ccgacagcgg
     2821 caagggcggc gattacggcg atatcgtggt catcctgcgc aacgacgacg gcacaccgct
     2881 gcttgacgag aacggcaatg ttcagccctg cctggacgcg gcctgcgagg aggtcatcca
     2941 gctggttcag gaggaggacg gcaagttcga gatccccgag gagtatatcg atcaggtgat
     3001 cccggttgag ttcggccgcc tcaacgtggc acggtccccc tccagcgtaa ccgatcactc
     3061 cctggcggag ctgctcagca agatggacgg cgtggaaatc tcggcagaca ccctggccga
     3121 gatgaccgac acctccggcc gcctgatcac cccggacggc gccaccatcg actcgccgct
     3181 ggagaacctg gccttctatg tagccctgct cgaagccacc aaccaggagc cggtggacgg
     3241 cttctacacc atctccatca ccaccaatcc gcgtggcgat gggcagcccg acgcctactc
     3301 gatgacggtc gatgcagaca tcctgcttac cctcgccgcc tcggccctgg ccgccagctc
     3361 cgacaagtac ggcgacctga ccatcgacga ggtgatgggg atcagcggct tcctgggagt
     3421 cgccgatgag ctgtcggcac tggtggggtc ggacagctac agctatgacc gcgaatccct
     3481 ctacggcggc atcgaggtca cggtgctcag ggaagtcgag atcgacggca ccatctacta
     3541 tcagcccact tctgtcgtgc tgctggatga ggtcgtgttc aacaccgtgc cgaccatcga
     3601 ggacaacggt tacggcatcg ataccttcac ccagcaggcg gacgatgccg tccaggtcct
     3661 ggaatacgtc cacgacttcg gcctcgaatc cgaatgatcg tgatcccgat gtaatcagac
     3721 gaaacgcggc ccccttgcgg ggccgccctt gtctcgacag gaggcatcca tgacagcgcg
     3781 acactcccct gccctgcgac ggctgctggt ggccggcctg ctgccactgg ccctggcagt
     3841 aggcagcgcc cagggcgcag gcttcagcgc ctcgcccccc ctccctgacc ctggcctgct
     3901 gctggccagc agcgaccatg ccgatggcca cgacagccat ggcgggagcg accgcggcca
     3961 gcgcggcggc cagggccagg gcaagcgtct cggcaagggg gccggcaccg gcgaggcccg
     4021 gggcggccac tcggtgaccg acgacatttt ccgcgacgag ggcttctccc ggggcaaccc
     4081 ggaccgcggc ggcggcccgc ccgagggacg gggcgagcac gaggacggcg acgaccacga
     4141 ccatgaggag ggggatgacc acgatagcgg cccgcccgaa gggcgcggcg gtggccatga
     4201 gtcgggcgaa gagcacgacc acgagagctg aggccgcacc tggccggctc cttggccgag
     4261 cggaaaccgg gagccggcca tgtcaggcat ggcggcagcg atcatgatcg cctagtattc
     4321 ctgtaccctt atttgacaag gatagagaaa tgtacaggaa aatggcatgg tggctggccc
     4381 tggtgctgct cctggcgggc tgcagcagcg tcgacatcga tcgctacgcg gacaccaccc
     4441 cgaggctaga tatcggcgag tacttcgccg gccagacccg cgcctggggc atggtccagg
     4501 actaccgcgg cgaggtccag cggcgcttca ccgtggagat cgagggcgac tacgacggcg
     4561 ataccctgac cctggacgag cacttcgtct acgacgacgg cgagaccgac cgccgggtct
     4621 ggaccttcca gcgccaggac gacggccgct gggtgggccg cgccaacgac gtcgaggggc
     4681 cggtggaggc tcgccagtcg ggccacgcct tcaacatgac ctatcgactg cccgtggagg
     4741 tctcgggacg cgagatcacc ttcaccctgg acgactggat gttcctgcag cccgacgacc
     4801 gcctgatcaa ccgcaccgcc atgaagaagt tcggcatcac cctggccgag atcaccatcg
     4861 tcttcgaacg cctcgacggc gacgccgact cccccgacgc agataccctc tcggacacca
     4921 acgcagacgc ccccggcacc tgaggtgccg ggggcgtcat catgccctgg cgtggctcgc
     4981 cggccggtgc cgccggggtc tcagccctcg tcggccgggg cgtaggagcc atcctcgcga
     5041 tgcacttcct tgccggtcag gccgggcgtg aagacacagg ccaggtgcat ggtcttgcgg
     5101 gcgcgcagca ggtgctcgtc atgctggtcg aggatataga tatcgcccgg cttgatcggc
     5161 cagatcttgc cgtcggccag ggtctcgacc tcgccctccc cctcgatgca gtagaccgcc
     5221 tcgaagtggt gcttgtagtg gatgtgggtc tcggtcccct cgtagatacg ggtgatgtgg
     5281 aaggagcagt tgccgccatc atcggccagg ctcaggcggg tgctgtccca gttgccgttc
     5341 tcggccttga ccaggcgatc ggtcttgcgg cattcctcga gattgcgaac gatcatggat
     5401 gatctccagt ggtgtccagg aaggaccggc cggtgacacc ggccggtcgg tgaccagacc
     5461 gcccgggggc ggtcccctca gcctatcagc tcagcgcctg cttggcgctg gcctcgagga
     5521 tatccagccc cttgtgcagg tcggcgtcgg ggatggtcag cgggcagagg cacttcacca
     5581 cctcgccgtc ctggccgctg gtctcgatga ccaggccgtt ctcgaaggcc tggtgggtga
     5641 tcttgtcggc gatctcgccg gtgcccacgt cgatgccgcg catcaggcca cggccccgct
     5701 cggaggcctc gatgccctgc tcgcggatcc aggcggcgat gccggcgaag cgctcggcga
     5761 cgatctcgcc cttgcgctgg acgtcgcgct cgaactcgtc gttgccccag tagtggcgca
     5821 gagccgccgc ggcggtggtg aaggccaggg cgaagccgcg gaaggtgccg ttgtactggc
     5881 ccggcttcca ggcgtcgagc tccgggcgca tcagcacctg ggcgaagggc aggccgaggc
     5941 cggagagcga cttggagttg gtgacgatgt cgggcaccac gccggcatgc tcgaagctga
     6001 agaacttgcc ggtgcggccg cagccggcct ggatgtcatc gacgatcagc aggatgtcgt
     6061 gggcgcggca gatctgctcc aggcgcttga gccattcggt gctgcaggcg ttgatgccgc
     6121 cctccccctg caccgtctcg acgatcacgc cggccggtac gtcgaggcca ccggacttgt
     6181 cggaaagcag cttctcgaag tagtccaggg tgtcggtgcc atcgcccagg tagccgtcat
     6241 agggcaggaa gctgccgccc acggtgggca cgccgccggt ggcctcgcgg aacttgcggt
     6301 tgccggtggt ggccagcgcc cccatggtca cgccgtggaa gccgttggtg aaggtcacga
     6361 tgttgtggcg acccttggca ttgcgcgcca ggcgaatcgc cgcctccacg gcattggtgc
     6421 cggtcggccc gggaaactgc accttgtagt ccagcccacg cggcttgagg atcagttcct
     6481 cgagggtggc caggtagtcc cgcttggcgg cggtccagaa gtccaggccg tggatgatgt
     6541 tgtcctcggc caggtagtcc agcagcgcct gcttgatctt cgggttgttg tggccgtagt
     6601 tcagggtgcc ggcgccggcc aggaagtcga tgtactcgcg accattctca tcggtgaggc
     6661 gggcgttggt ggccttggtg aagaccaccg ggaaggagcg ggaataggtg cgaacgtcgg
     6721 attccatgcg ttcgaggatc tgggtctgca tgagcgacct cctgtcggta ggaagtgaag
     6781 gacgagagga accggcggcc ggcatgacgc cggccgtcga caagacggga aggaatcaga
     6841 tgcggtcggt ctggaaggga ccgatgcgca ccaggttctc ggggtcgtgc tcgccaccga
     6901 gctggtcggt ggagaagtac tcgcggctgt tgagcggcgc ctgccagcga tcggcgagac
     6961 gacggaacag cccccaggag gcctggttgt cgggggtgat ggtggtctcg aggtggtgga
     7021 cctcggccag ttccgggcga gacatcacgg cctcgaccag gcgccgggcc aggccggtgc
     7081 cgcgggcctt ctcgcccacg gcgacctgcc agaggaagta ggtgtccggg gcattgctct
     7141 tcacgtagcc cgacacgaag ccgacgatct ccccctcctc gttggtggcc accgcgcagg
     7201 tgtcgcggaa ctgggtcgcc agcagcaggt aggcataggc ggagttcacg tccagcggcg
     7261 gacaggactt gaccagttcg tagatgcccc acccatcgtc cgggttcggc ttgcggatga
     7321 acagcggcat ggcatcgaag ccgacgacgg catcggccac ggtcgggcgg gccaggtcgg
     7381 cggaaggcgt gaagggttcg gttgttgtca tctcggctgg ttcgctgtag cgaatttgga
     7441 aggcattata acagtggcat cccgcatttc aaagctggga ttattctgca cccgcggatc
     7501 cataacagga gattatgcca gtgccgggaa cggtcgccgg aactctgcct gttgcctggg
     7561 tggcgccacg ggacgcgccc tgcccttcca gaatagccca cttccggcgt ccagggagcg
     7621 cggggcgaaa cgccgacggg ccgccccgag gggcggcccg tgatgccgac gacagacccg
     7681 cgggcgctca gcgccgcgtc ggggagcgca tggtgacgaa ctcctccgcc ccggtgggat
     7741 ggatccccac cgtggcgtcg aaggcggcct tggtcaggcc ggcacgcacc gcgatggcga
     7801 tgccctggat cacctcgccg gcctcctcgc ccaccatgtg ggcgccgacc accacgtcgc
     7861 tggcatcgtc gacgatcagc ttcatcaggc agcgctcgct gctgcccgac agcgtgtgct
     7921 tcatgggccg gaagtcggcg gtgtagaccc ggatctcgcc gcactgctcg cgggccgcct
     7981 cctcggagag ccccacggtg ccgatgttgg ggtggcagaa gacggccgtg gcgatgttgc
     8041 ggtagtccag cggtgacccg ggcggggtct cgccgaagtg gtgctggacc atgtgcatgg
     8101 cctcggccag ggccaccgga gtgagctccg gcccgccggt gacgtcgccc agtgcgagga
     8161 tcgacggcag cgaggtctcg aagcggtcgt tgacccgcag gtagccgccg tcgtcgagct
     8221 ccaggcccag cgcctcgagg cccagccccg ccaggtgcgg ccggcgcccg gtggcggcca
     8281 gcaccgcgtc cacctcgtgt cgctcgccgc tggtcagggt caccgccagg ccgccctcga
     8341 cccgctcgat ggcggcgatg ttctcctcga agtgcaggtt gacccccttg gccgccatct
     8401 ggtcccgggt gaactcgcgc acctcgcgat cgaagccgcg caggaacagg tcgccgcggt
     8461 agaccaggtg cgtctcgctg cccaggccgt tgaagatgct ggcgaactcc acggcgatgt
     8521 agccgccacc cagcaccagg aagcgctccg ggaaggtgtc gaggtcgaac acctcgttgg
     8581 aggtcagggc cagctcgctg ccggggaagt cgggcaccca gggccagccc cccacggcca
     8641 ccaggatctt cgcggcggtg tgggtctcgc cggccacctc cacggtatgg gggtccacca
     8701 cccgggcgcg gccatggatc agctggactc cggcgccctc gagcaggcgg ccgtagatgc
     8761 cgttgaggcg cttgatctcg ccgatcttgt tgtcgcgcag cgtggcccag tcgaattcgg
     8821 gcgcctccgc gagctgccag ccgaagccgg cggcgtcctc gaaggcgtca tggaaatggg
     8881 cggcatagga gtagagcttc ttgggcacgc agccgacgtt gacgcaggtg ccgcccaggt
     8941 agcgatcctc ggccacggcg acccgggcac cgctggccgc cgcggtgcgg gccgcacgca
     9001 caccgcctga gccggcgccg atgacgaaga ggtcccagtc atgctggggg gcgaggttct
     9061 cggacacggg ggtctccttc tgctgtggcc gcaagggccg acacgtcgtg gccgcatcat
     9121 accagccgag ccggggcctc ggcaggcgtc gatttgaccc accgtcggtc aggcggtaaa
     9181 aggagccacc ggtcgcaagg ccacccccgt cccaccaccg gatacgctct ccgatgaacc
     9241 aggaaatcga aggcctgctg gacaacaacc gagcctgggc cgcacgggtc agccaggatg
     9301 accccgactt ctttgcccgc ctgtcgcggc agcagaaccc cgcctacctg tggatcggct
     9361 gttccgacag ccgggtgccg gccaaccaga tcatttccct gccgcccggc gaggtgttcg
     9421 tgcaccgcaa cgtggccaac ctggtgcacc ccaacgacct caacgcgctg tcggtgctgc
     9481 agtacgccgt cgaggtgctc ggcgtccgcc acatcatggt ggtgggccat tacggctgcg
     9541 gcggggtgcg cgcggcggtc agcggcggag acaacggcat ggtcgacatc tggctgcact
     9601 cggtccggga actctacagc cgccatcgcg cctcactgtc gacactgccc ctggacgagc
     9661 aggtggaccg catgtgcgag ctcaacgccc gggaccaggt gatgaacctg tgccgcacca
     9721 agatcgtcca gcacgcctgg cagcgcggcc aggagctggc cgtccacggc tgggtctacg
     9781 ggctggcgga cgggcgggtg aaggacctgg actgcacggt gtcgggcctc gaccaggtgg
     9841 ataccctcta ccgcatcgag cggctgacgc cggccggctg agggtcagta ccggtagcga
     9901 cggtgacagc tgcggcaggt caggctcagg tccgacagct cgcgggtcgc cgccgcgtag
     9961 tcctccgcct ccgcggcggc ccgtagcgcc tcgacgcggg cctccagagc gtcgaagccc
    10021 tcgctgaagg cctcccactc ctcccagatg cgggcacggg cctcggagcc gcgcccgtgg
    10081 ctgccctcga tgaaggccgg acggaggtgg tcgccgctgg cccgctcggc cagttcctcc
    10141 agccggggcg ccgcaccgcg ggcatcgcgg ttgttcacca gatcgaagcg cagctggcgc
    10201 accagccgct cgatctcctt gagctcctcc cgccgccagg tcaccgcctg gcgcggatcc
    10261 tcgaaggccg gggcgctgcc gttggccgcg gcggcgtccg cggccggttc ggccagcagc
    10321 ggcgtcatcg gcaggccggc gagcagcagg acgaataagg ggcgggtgag catgtcgtcg
    10381 actcccaggt ggtccg
//
