LOCUS       NC_009633.1            10913 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_009633.1 Alkaliphilus metalliredigens QYMF, complete sequence.
ACCESSION   NC_009633
VERSION     NC_009633.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:10:54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1072679
            Orig. end    :: 1083592
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..132
                     /locus_tag="ctg1_1036"
                     /transl_table=11
                     /translation="MCKLEEVRRTILLIIFIAIAIIFIADLEDIPGPAVPSLPIIIP"
     protocluster    1..10913
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[1077253:1079461](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4575..6782
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10913
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10913
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="5"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             180..527
                     /locus_tag="ctg1_1037"
                     /transl_table=11
                     /translation="MFSPDQLNELIKEVMINQQMGSNDNPNQNKHKYKHEEQQNKSQFN
                     ITPSQALVVLGLLTGALQVVSVLVDREQSVQLVLSGSLKKKEQSELEKVMGQIGHLPFD
                     EVVKAMMGRLK"
     CDS             715..1653
                     /locus_tag="ctg1_1038"
                     /transl_table=11
                     /translation="VKKWQWAVVVSLCSIIVVTMIYGYSIYRGYKNTLNHISVISENVD
                     IEQGEEFYNQDELESFVMLIYGISARKQLGDMGRSDTMMLALVDPNEMEISLISIPRDA
                     YVQIPGYRMDKINGAYPRGGSELMMKTIEEWLDIQVNSFASINFQGFVDLVDLVNGIKV
                     EVSRKMEYDDPADGTRIRLYPGEQVLDGKNALDFVRFRQSNDGRHASDYDRMLRQQEAL
                     QALAGKKTSVRTLTRAFDMMNILSENVQTSLTPGELEKLIRIFLSFKPEDLQTTSIQGE
                     GYYHNGGWYERVPQTEVERIQEIIRGFLSIN"
     aSDomain        946..1398
                     /aSDomain="TIGR00350"
                     /aSTool="tigrfam"
                     /description="lytR_cpsA_psr: cell envelope-related function
                     transcriptional attenuator common domain"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1038_0020"
                     /evalue="3.10E-39"
                     /identifier="TIGR00350"
                     /label="ctg1_1038"
                     /locus_tag="ctg1_1038"
                     /protein_end="228"
                     /protein_start="77"
                     /score="132.6"
                     /tool="antismash"
                     /translation="GRSDTMMLALVDPNEMEISLISIPRDAYVQIPGYRMDKINGAYPR
                     GGSELMMKTIEEWLDIQVNSFASINFQGFVDLVDLVNGIKVEVSRKMEYDDPADGTRIR
                     LYPGEQVLDGKNALDFVRFRQSNDGRHASDYDRMLRQQEALQALAGK"
     PFAM_domain     949..1398
                     /aSDomain="LytR_cpsA_psr"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03816.16"
                     /description="LytR_cpsA_psr family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1038_0065"
                     /evalue="1.70E-41"
                     /label="ctg1_1038"
                     /locus_tag="ctg1_1038"
                     /protein_end="228"
                     /protein_start="78"
                     /score="142.0"
                     /tool="antismash"
                     /translation="RSDTMMLALVDPNEMEISLISIPRDAYVQIPGYRMDKINGAYPRG
                     GSELMMKTIEEWLDIQVNSFASINFQGFVDLVDLVNGIKVEVSRKMEYDDPADGTRIRL
                     YPGEQVLDGKNALDFVRFRQSNDGRHASDYDRMLRQQEALQALAGK"
     CDS             1865..3589
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 102.6; E-value: 5.3e-31)"
                     /gene_kind="other"
                     /locus_tag="ctg1_1039"
                     /transl_table=11
                     /translation="LYRIDNEFNGVMLLFSVKEKKIELDQQYMKLIWLWVGLLATFHFV
                     GVLGEKYYTVLEINSFIYHHTYLEFISIIISFMIFIVTYYTYDKNKRARLLIFFPMFFI
                     VGMIDFFHTMVYEGMTGFFVESNAPMATTFWIIGRLIFAMGMLGAALVPYQLKTNYKRV
                     YFVLVSIGVSGLVFYLVAYQIHLFPALFIEGQGLTPLKVVLEYFIMALMIGAIFLYMRD
                     YQKTKNLVFIYVIAGLSFGIFAEASFTLYKSVHDTYNFMGHIYKAISSYLIFKGIFIYN
                     LDAPYLKLAEARTKLIEYTENLEEIVEESTQEVKKVNEKVLEDLEYARRIQQSLLPEKE
                     LLIDGIAFSSEYIPCSNLSGDLYDVYKINDDCIGIFIADVAGHGVSAALMTMFIERVLV
                     SDTINTIQGIEDSCEKPLMNLYNVFNESDFPDEMHIAVFNAIYHIPTKTLSYCTAGMNS
                     VPMVVRNSGEVEMLDQSQGFPICKLGDFFHPQYVKAEARLEEGDRIFFYTDGLVENFKS
                     HTLIQENTLKKMLYENKHLLGPELKMKISREICKRTQIEEIEDDITFLIMDILQSKR"
     PFAM_domain     2033..2719
                     /aSDomain="MASE3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF17159.6"
                     /description="Membrane-associated sensor domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1039_0066"
                     /evalue="1.20E-63"
                     /label="ctg1_1039"
                     /locus_tag="ctg1_1039"
                     /protein_end="285"
                     /protein_start="56"
                     /score="214.9"
                     /tool="antismash"
                     /translation="EINSFIYHHTYLEFISIIISFMIFIVTYYTYDKNKRARLLIFFPM
                     FFIVGMIDFFHTMVYEGMTGFFVESNAPMATTFWIIGRLIFAMGMLGAALVPYQLKTNY
                     KRVYFVLVSIGVSGLVFYLVAYQIHLFPALFIEGQGLTPLKVVLEYFIMALMIGAIFLY
                     MRDYQKTKNLVFIYVIAGLSFGIFAEASFTLYKSVHDTYNFMGHIYKAISSYLIFKGIF
                     IYNLDAP"
     PFAM_domain     2969..3568
                     /aSDomain="SpoIIE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07228.14"
                     /description="Stage II sporulation protein E (SpoIIE)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1039_0067"
                     /evalue="4.30E-28"
                     /label="ctg1_1039"
                     /locus_tag="ctg1_1039"
                     /protein_end="568"
                     /protein_start="368"
                     /score="98.6"
                     /tool="antismash"
                     /translation="NDDCIGIFIADVAGHGVSAALMTMFIERVLVSDTINTIQGIEDSC
                     EKPLMNLYNVFNESDFPDEMHIAVFNAIYHIPTKTLSYCTAGMNSVPMVVRNSGEVEML
                     DQSQGFPICKLGDFFHPQYVKAEARLEEGDRIFFYTDGLVENFKSHTLIQENTLKKMLY
                     ENKHLLGPELKMKISREICKRTQIEEIEDDITFLIMD"
     CDS             3723..4100
                     /locus_tag="ctg1_1040"
                     /transl_table=11
                     /translation="MIIEGFFENIKNANQVVSVLNELQVRAYVDIKDDDKEDQNVMRNV
                     AGTETGTSLSELTLNSGNGDLDASKAPIAAADPMASGMAGFEEITNQNYKVTVEVGEEK
                     INLAMETIEKMGGTLDDRNVY"
     CDS             4575..6782
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 315.4; E-value:
                     1.3e-95)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1041"
                     /sec_met_domain="TIGR01193 (E-value: 2.2e-207, bitscore:
                     688.9, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.1e-41, bitscore:
                     137.8, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKKYHCIKQHDIADCGAACLATISKNYGLKIPITKIREVAGTDK
                     QGTNAYGVIKAAEQLGFSAKGVKGDQEAFFSEFPLPAIAHVVMEGSLLHYVVIHKITKK
                     EVIIADPGKGIVKYTPEEFFKLWTGVLIILIPSPQFQKGNETKGLFKRFFGILKPQKKL
                     VINIFFASIVYTILGIIGAFYFKILMDDILRYNLTKTLHIITAGIIILNIFKILLNAFR
                     SHLLLYLSQRMDIPLILGYYQHVIDLPMSFFGTRKVGEIISRFMDASKIREAISGATLT
                     IMIDTLMAIAGGIILYTQNASLFGIAVIMLFLYGILVAVFNKPIKEISQKEMENNAQLT
                     SYLVESLNGIETVKAFNAERQAKTETETKFVKLLRNILKAGTIYNLQGSLSNAVGTIGG
                     IIILWAGAYKVIQGEITVGQLLVFNSLLAYFIDPVKNLINLQPMMQTAIVASDRLGEIL
                     DLKLEKSPEENKKVSPKTLKGEIQFKNVDFRYGTRELVLKNIGLTIKPGEKIALVGESG
                     SGKTTLAKLLMHYYTNEKGDILINQYNIKDINIEKLRERIAYISQDIFMFSGTIKENLS
                     LGNKDITLEEMIEAAKQSSAHDFINQLPLRYDTLLEENATNLSGGQKQRLAIARALLKN
                     PDILIMDEATSNLDSITEKAIEKTIAGFNQEITTIIIAHRLSTIMQCDTIYVLDKGEII
                     ETGSHEVLMDKRGKYFNLWKEQLPEYQETNQTNQQLGESTV"
     PFAM_domain     4587..4985
                     /aSDomain="Peptidase_C39"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03412.17"
                     /description="Peptidase C39 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1041_0068"
                     /evalue="2.00E-40"
                     /label="ctg1_1041"
                     /locus_tag="ctg1_1041"
                     /protein_end="137"
                     /protein_start="4"
                     /score="137.8"
                     /tool="antismash"
                     /translation="YHCIKQHDIADCGAACLATISKNYGLKIPITKIREVAGTDKQGTN
                     AYGVIKAAEQLGFSAKGVKGDQEAFFSEFPLPAIAHVVMEGSLLHYVVIHKITKKEVII
                     ADPGKGIVKYTPEEFFKLWTGVLIILIPS"
     aSDomain        4602..6713
                     /aSDomain="TIGR01193"
                     /aSTool="tigrfam"
                     /description="bacteriocin_ABC: ABC-type bacteriocin
                     transporter"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_1041_0021"
                     /evalue="2.10E-207"
                     /identifier="TIGR01193"
                     /label="ctg1_1041"
                     /locus_tag="ctg1_1041"
                     /protein_end="713"
                     /protein_start="9"
                     /score="688.9"
                     /tool="antismash"
                     /translation="QHDIADCGAACLATISKNYGLKIPITKIREVAGTDKQGTNAYGVI
                     KAAEQLGFSAKGVKGDQEAFFSEFPLPAIAHVVMEGSLLHYVVIHKITKKEVIIADPGK
                     GIVKYTPEEFFKLWTGVLIILIPSPQFQKGNETKGLFKRFFGILKPQKKLVINIFFASI
                     VYTILGIIGAFYFKILMDDILRYNLTKTLHIITAGIIILNIFKILLNAFRSHLLLYLSQ
                     RMDIPLILGYYQHVIDLPMSFFGTRKVGEIISRFMDASKIREAISGATLTIMIDTLMAI
                     AGGIILYTQNASLFGIAVIMLFLYGILVAVFNKPIKEISQKEMENNAQLTSYLVESLNG
                     IETVKAFNAERQAKTETETKFVKLLRNILKAGTIYNLQGSLSNAVGTIGGIIILWAGAY
                     KVIQGEITVGQLLVFNSLLAYFIDPVKNLINLQPMMQTAIVASDRLGEILDLKLEKSPE
                     ENKKVSPKTLKGEIQFKNVDFRYGTRELVLKNIGLTIKPGEKIALVGESGSGKTTLAKL
                     LMHYYTNEKGDILINQYNIKDINIEKLRERIAYISQDIFMFSGTIKENLSLGNKDITLE
                     EMIEAAKQSSAHDFINQLPLRYDTLLEENATNLSGGQKQRLAIARALLKNPDILIMDEA
                     TSNLDSITEKAIEKTIAGFNQEITTIIIAHRLSTIMQCDTIYVLDKGEIIETGSHEVLM
                     DKRGKYFNLW"
     PFAM_domain     5064..5876
                     /aSDomain="ABC_membrane"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00664.25"
                     /description="ABC transporter transmembrane region"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1041_0069"
                     /evalue="1.70E-53"
                     /label="ctg1_1041"
                     /locus_tag="ctg1_1041"
                     /protein_end="434"
                     /protein_start="163"
                     /score="182.1"
                     /tool="antismash"
                     /translation="VINIFFASIVYTILGIIGAFYFKILMDDILRYNLTKTLHIITAGI
                     IILNIFKILLNAFRSHLLLYLSQRMDIPLILGYYQHVIDLPMSFFGTRKVGEIISRFMD
                     ASKIREAISGATLTIMIDTLMAIAGGIILYTQNASLFGIAVIMLFLYGILVAVFNKPIK
                     EISQKEMENNAQLTSYLVESLNGIETVKAFNAERQAKTETETKFVKLLRNILKAGTIYN
                     LQGSLSNAVGTIGGIIILWAGAYKVIQGEITVGQLLVFNSLLAYFIDPV"
     PFAM_domain     6063..6512
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1041_0070"
                     /evalue="1.00E-37"
                     /label="ctg1_1041"
                     /locus_tag="ctg1_1041"
                     /protein_end="646"
                     /protein_start="496"
                     /score="129.8"
                     /tool="antismash"
                     /translation="LKNIGLTIKPGEKIALVGESGSGKTTLAKLLMHYYTNEKGDILIN
                     QYNIKDINIEKLRERIAYISQDIFMFSGTIKENLSLGNKDITLEEMIEAAKQSSAHDFI
                     NQLPLRYDTLLEENATNLSGGQKQRLAIARALLKNPDILIMDEATS"
     CDS             6779..8254
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 94.6; E-value:
                     9.3e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_1042"
                     /transl_table=11
                     /translation="MKGIVQNLNDITDSRELLESRPHPFTVIFIYLLIGLLAIAFIWTY
                     IGEIDIVVKANGVVRPNQRISTINNIVPGKVKELYIENGKTVKKDDILYTIDHTELKNK
                     QAFIEEELSRKKTELKNQNIFKQSIIENKNSFNQQEKDQEVHYYKYIKYQAEQGQTKEN
                     VNLIISKINTTQTILQNTQTLLTAIENNENKFEDTENEYYIKFLDYSLNLKDLQKEVDK
                     KKIDLEIQEKLHQSGAVSQMDYKNVKDMLEKMQLEKKRFENSTRLSLKTSMEENQRLLN
                     QLEIQLQQIAPGIVEQIENHPDIAAANHRTENIIAINETIKYLEAEINQLQNNLKGIKL
                     DIENSISKAPIDGHINIITDINQGDNIQAGTPIATIIPYDDSNYTVRIYASNEDIANIN
                     IGDKVKYNFMALPYKEYGELTGKITRIATDTKTTQEGNTSYYLVESDIETRALISYKGE
                     EADIKVGMVCEARVVTKTKKILHYLLEKIDLRL"
     PFAM_domain     6977..7114
                     /aSDomain="Biotin_lipoyl_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13533.8"
                     /description="Biotin-lipoyl like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1042_0071"
                     /evalue="1.30E-11"
                     /label="ctg1_1042"
                     /locus_tag="ctg1_1042"
                     /protein_end="112"
                     /protein_start="66"
                     /score="44.1"
                     /tool="antismash"
                     /translation="TINNIVPGKVKELYIENGKTVKKDDILYTIDHTELKNKQAFIEEE
                     L"
     PFAM_domain     7820..8170
                     /aSDomain="HlyD_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13437.8"
                     /description="HlyD family secretion protein"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1042_0072"
                     /evalue="8.30E-18"
                     /label="ctg1_1042"
                     /locus_tag="ctg1_1042"
                     /protein_end="464"
                     /protein_start="347"
                     /score="65.1"
                     /tool="antismash"
                     /translation="KAPIDGHINIITDINQGDNIQAGTPIATIIPYDDSNYTVRIYASN
                     EDIANINIGDKVKYNFMALPYKEYGELTGKITRIATDTKTTQEGNTSYYLVESDIETRA
                     LISYKGEEADIKV"
     CDS             8550..8828
                     /locus_tag="ctg1_1043"
                     /transl_table=11
                     /translation="MFKEMTQKEMMMLDGGKRRSSTRHERSGGYSRVTDEARQSHINVV
                     VGAAVSAVLGGAGGAAFGGSVGSGVLGGGVSGSIGSGIADTIVNKLN"
     CDS             9183..9410
                     /locus_tag="ctg1_1044"
                     /transl_table=11
                     /translation="MKTRKLLLIYTIFFVIYGFGFSFVINYPDLYSLHYMWFAVVTTII
                     LLISIRLFKLIDDRITCLEEKIKINKNTQN"
     CDS             10089..10913
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_1045"
                     /sec_met_domain="Abi (E-value: 8.3e-13, bitscore: 46.7,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKFSSSVKNGFFLYFLIVLSSNLFYFSTRNIGLSRLIRVLIIQY
                     FFYLLIPITCLMLNKKIIKKDLRLNKINWKQFRLIFLISILAVPISTYLNNVVLVVLSL
                     FGDYTRIQRLITDVTSFYTLIASIFIFVITPAICEETMFRGFLMNEFKSIGVRKSIILT
                     AVLFSIFHLDIEFLLGATFIGIIFGYLVHITNSLYAGIIAHGIFNLTGSLLKFLLLNGS
                     SDIAGDIVIWKEIIPVILLGIMPSCVFVALSWLLIKKLIETVNNTPQNFEVE"
     PFAM_domain     10461..10715
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_1045_0073"
                     /evalue="2.80E-12"
                     /label="ctg1_1045"
                     /locus_tag="ctg1_1045"
                     /protein_end="209"
                     /protein_start="124"
                     /score="46.9"
                     /tool="antismash"
                     /translation="IASIFIFVITPAICEETMFRGFLMNEFKSIGVRKSIILTAVLFSI
                     FHLDIEFLLGATFIGIIFGYLVHITNSLYAGIIAHGIFNL"
ORIGIN
        1 atgtgcaaat tagaagaagt gcgcagaact atattactca ttatattcat cgcaatagcg
       61 attattttta ttgctgactt agaagacatt ccaggacctg ctgtacctag tctaccaatc
      121 atcattccat aatataaggt ggaataaggg acaaatacat aagggggagg aggaaatgaa
      181 tgttttcacc agaccaattg aatgaattaa taaaggaagt tatgataaat caacaaatgg
      241 ggagcaatga taatcctaat caaaataaac ataagtataa acatgaagag caacagaata
      301 aaagtcagtt caatatcacc ccatctcaag cactggtggt tttaggcctt ttaaccggtg
      361 cactgcaggt ggtatccgtt ttagtggatc gggagcaatc tgttcaactg gttttatctg
      421 gatccctaaa aaagaaggaa cagtcagaat tagaaaaagt aatggggcaa attggacatc
      481 ttccctttga tgaagtcgtg aaagcaatga tggggaggtt gaaataaaat gagacttaat
      541 tcataggact tttcattctt atgtatgaag tctcatttta tgattaagca gtataatctg
      601 tgcaatgatg agagcgtatc tcgtcaatgt ttgacaaaaa aacaaggatt gcttatactt
      661 agttttgaga atgaaatatc atcataactt cagtacgtga agggagaaag tgccgtgaaa
      721 aaatggcaat gggctgtggt agttagtttg tgctctatca ttgtggtaac aatgatttat
      781 ggttacagca tatatagagg atataaaaat acactcaatc atatatcggt tatcagtgaa
      841 aacgttgata ttgagcaagg ggaagaattc tataatcaag atgaactaga gtcctttgtg
      901 atgttaatct atggaattag tgcccgtaaa caactagggg atatggggag atcagacaca
      961 atgatgctgg ctttagtaga ccctaatgaa atggagatca gccttatctc tatccctagg
     1021 gatgcatatg ttcaaatccc agggtatcga atggataaaa tcaatggggc ctatcctagg
     1081 ggaggctcag agttgatgat gaaaaccatc gaagaatggc tagatatcca agtaaacagc
     1141 tttgcttcta ttaatttcca aggttttgtt gatttggtag atttggttaa tgggatcaaa
     1201 gtggaagtgt caagaaaaat ggaatatgat gaccctgcag atgggacaag gattcgatta
     1261 tatccaggag agcaagtgtt agacggaaaa aatgccctgg actttgtgcg cttcagacaa
     1321 agtaatgatg gaagacatgc cagtgattac gatagaatgt taagacagca ggaggcacta
     1381 caagccttag cagggaaaaa gacttcagtt cgaacactga ctagggcctt tgacatgatg
     1441 aacatcttaa gtgaaaatgt acaaacctct ttaacgcctg gtgaattaga gaaattaatt
     1501 cgcatctttt tatcctttaa accagaggac ttacaaacta cctctattca aggagaggga
     1561 tactatcaca atggcggatg gtatgaacga gtaccacaga cggaagtgga gcgaattcaa
     1621 gagattattc gaggattttt aagtataaat taagtagaga agagcatctt ccaagccggg
     1681 taaggaggat gtcttttttt aattgatatt catttttgat aatccctaca atgggcttat
     1741 tgcctgaaat aaagacgcct tcaacgatca atatattttt tgtttaataa tgatatttta
     1801 cttgccaaat caatattaaa gaggattttc agagaaaatg tagaaatgtg gagaagtgag
     1861 gcttttgtat agaatagaca atgaatttaa tggggtgatg cttttgttta gtgtaaagga
     1921 aaaaaaaata gagctggatc agcaatatat gaagcttata tggctctggg tgggtttatt
     1981 agctacattt cattttgtag gtgtattggg ggaaaagtac tacactgttt tagaaatcaa
     2041 ttcctttata taccatcata catatttgga gtttattagt attatcattt catttatgat
     2101 ctttattgta acctactaca cctatgataa aaacaaacgt gcaaggttac tgattttttt
     2161 tcctatgttt ttcattgttg gaatgataga cttttttcat acaatggttt atgaggggat
     2221 gacaggtttt tttgtagaga gtaatgctcc tatggcaacc acattttgga taataggtag
     2281 gttgatcttt gccatgggga tgctgggtgc tgctttagtg ccctatcaat tgaaaaccaa
     2341 ctataaaaga gtgtattttg ttttagtaag tataggcgtt tctggacttg tattttattt
     2401 agtcgcttat cagattcatt tattcccagc tttgtttata gaggggcaag ggctaacgcc
     2461 attgaaagtt gtcttggaat actttataat ggccctcatg ataggagcaa tatttttata
     2521 tatgagggac tatcagaaaa caaaaaacct agtttttata tatgtgatcg caggattgtc
     2581 ctttggaatt tttgctgaag catcctttac cctctataag agtgttcatg atacatacaa
     2641 cttcatggga catatttaca aggcaattag ttcatatttg atttttaagg gtatttttat
     2701 ttataattta gatgcacctt atttaaagct agctgaagct cgaacaaagc taatagaata
     2761 tactgaaaac cttgaggaaa tagttgaaga aagcacccaa gaggtaaaga aagtcaatga
     2821 aaaagtccta gaggacttgg agtatgccag aagaattcaa cagtcattac tgccggagaa
     2881 agagctactc attgatggta tcgccttttc ttcagaatat atcccttgta gtaacttgag
     2941 tggtgactta tatgatgttt ataaaattaa tgacgactgt atcggtattt tcatcgcaga
     3001 tgtagcgggg cacggtgtgt ctgcggcctt gatgaccatg tttatagaaa gagtgctggt
     3061 ttctgatacc atcaatacaa ttcaggggat tgaggactct tgcgaaaagc ccttgatgaa
     3121 tctatataat gtgtttaatg aatctgattt tcccgatgaa atgcacattg cggtttttaa
     3181 tgcaatctat catattccaa ccaaaacatt atcctattgt acagcaggga tgaattctgt
     3241 gccaatggtg gtgaggaata gtggagaagt agaaatgcta gatcaaagtc agggattccc
     3301 tatctgtaag cttggagatt tctttcatcc ccaatatgta aaagctgaag cccgactgga
     3361 agaaggagat cgaatctttt tctacaccga tggattggtg gaaaatttta aaagccatac
     3421 attaatccaa gaaaatacat tgaagaaaat gttgtatgag aataagcatt tattaggacc
     3481 agagttgaag atgaaaataa gtcgagagat ctgtaagaga acccagatag aagaaattga
     3541 ggacgatatc acttttttaa ttatggatat tttacagtct aaaagataaa gattgattaa
     3601 aggataaagg atttaagaaa ggctggtatc ctccttgaag aaaaaagaca ccacatatcc
     3661 tgaatagaaa gaccacctta gatgaaaaat aaaagcaagg ttcatcataa ggaggaatca
     3721 agatgataat agaaggtttt tttgaaaaca ttaaaaatgc aaatcaagtt gtgagtgtgc
     3781 ttaatgagtt acaagtaaga gcttatgtag atataaagga tgatgataag gaagatcaaa
     3841 acgtgatgag aaatgtggca ggaacagaga ctggaaccag cttgtcggag ctgactctga
     3901 attcaggtaa tggagatttg gatgccagta aagccccaat agctgctgcg gacccaatgg
     3961 caagcggtat ggcaggcttt gaagagatca ctaatcaaaa ctataaagta acagtagaag
     4021 ttggggaaga aaaaatcaac ctagctatgg aaaccattga aaaaatggga gggacattag
     4081 acgatcgtaa tgtgtattaa attgtgtaaa tattatagat atgtaataaa accaaacggc
     4141 tgtgttcaca gtcgtttttg ctttatatta atttaatgta atgagttttt aaatgtagtc
     4201 ttgtatcaag ttatgtttta gaagaactga agctactgta ttgctttgca actcctctga
     4261 aagtggatga tgaaatcata ggatatgtaa aattagtttc tttagaataa aaaactacct
     4321 gaacgggtag tggtattctc ggaacgttga tggtaaaata agtacaaata tacatattta
     4381 gtaaaaatat accttgttat acatactgta aatcattata tttatggaag gaataaacat
     4441 gtaaataata tttctaaata ccatattaca aaataatctg caagtagtaa aaacaaccga
     4501 gtagtaatga taacccataa gattgaagcg gcaaataaag aacaaataat aaatatggaa
     4561 ataaaggtga tcagatgttc aaaaaatacc attgcataaa acaacacgat atagccgatt
     4621 gtggtgcagc ttgtttagcc accatttcaa aaaactacgg tctgaaaata cctatcacaa
     4681 aaattcgtga agttgctggc actgataagc agggaaccaa tgcctatgga gtcatcaagg
     4741 cagcagaaca actaggtttt agtgccaaag gcgtaaaagg tgaccaagaa gcgtttttta
     4801 gcgagtttcc actgcctgct attgcccatg ttgtaatgga gggttcacta ttacactatg
     4861 tagtgataca taaaatcaca aaaaaggaag tgatcattgc cgaccccgga aagggcatag
     4921 tcaaatacac tccagaagaa ttctttaagc tatggacagg agtgttaatc atattaatcc
     4981 ccagtcctca atttcaaaaa ggtaatgaaa caaagggcct attcaaaaga ttctttggca
     5041 tattaaagcc acagaaaaaa ttagtcatca atattttttt tgcatccatt gtatacacta
     5101 tactaggtat aatcggtgct ttttacttta aaattttgat ggatgacata ctaagataca
     5161 acctaaccaa gaccctacat atcataacgg caggaatcat tatattgaac attttcaaaa
     5221 tactcttgaa tgcctttaga agtcacctac ttttatacct aagtcagagg atggatatcc
     5281 ccttaatact gggctactat caacacgtga tagatttacc catgagcttc tttggaacaa
     5341 gaaaagtagg agaaatcatc tcaagattca tggatgcctc aaaaataaga gaagccatat
     5401 caggggccac actaaccatc atgatagaca ccctaatggc aatagctggt ggcatcatac
     5461 tctataccca gaatgcttct ctatttggca tagcagtgat catgcttttt ttatacggga
     5521 tactagtagc tgtatttaat aaacctataa aagaaatcag ccaaaaagaa atggaaaaca
     5581 acgcacagct tacatcatat ctagtagaaa gcctcaatgg catagaaacc gtaaaagcat
     5641 tcaatgccga gagacaagct aaaacagaga cagagacaaa gtttgtaaag ctcttgagaa
     5701 acatactaaa agcaggtacc atctacaatt tacaaggctc actaagcaat gcagtgggca
     5761 ccattggtgg cataatcata ctatgggcag gcgcatacaa agtgatacag ggtgaaataa
     5821 ctgtaggaca actactggta tttaactcac tcttagctta ctttatagat ccagtaaaaa
     5881 atctcattaa cctccagccc atgatgcaga cagccatagt agcctcggac cgactgggag
     5941 aaatactaga tttaaaacta gaaaaaagtc cagaagaaaa caagaaagtg agccccaaga
     6001 cactaaaagg tgaaatccaa ttcaaaaacg tagactttag atatggcaca agagagcttg
     6061 tactaaaaaa catcggccta accataaaac caggagaaaa aatagcacta gtaggtgaaa
     6121 gcggctcagg aaaaacaacc ctagcaaaac tactaatgca ttactataca aacgaaaaag
     6181 gcgacatcct aataaatcaa tataatataa aagacataaa catagaaaaa ctaagagaaa
     6241 gaatagcata catatcccag gacatattca tgttcagcgg aacaattaaa gaaaacctat
     6301 cattaggaaa caaagacatc accctagaag aaatgataga agcagcaaaa caatcaagcg
     6361 cccatgattt catcaatcag cttcccttaa gatacgacac cctgctagaa gaaaatgcaa
     6421 ccaacctatc aggaggacaa aaacaaagac tagccatagc aagggcactg ctaaaaaatc
     6481 cagacatact gatcatggat gaagcaacca gtaacctaga ctccataaca gaaaaagcca
     6541 tagaaaaaac catagcagga ttcaaccaag aaataacaac catcatcatt gcccatagac
     6601 tcagtaccat catgcagtgc gataccatct acgtcctaga caaaggcgaa ataatagaaa
     6661 caggaagcca tgaagtcctc atggacaaaa gaggcaaata cttcaaccta tggaaagaac
     6721 aactaccaga ataccaagaa accaaccaaa ccaaccaaca gttaggagaa agtacagtat
     6781 gaaaggaatc gtacaaaacc taaacgacat aacagatagc agagagctac tagaaagccg
     6841 cccccatccc tttacagtca tattcatata cctactaatc gggctgttgg caatcgcatt
     6901 tatctggacc tacatagggg aaatagacat cgttgtaaaa gccaatggcg tagtaagacc
     6961 aaatcaaaga ataagcacca ttaacaatat cgtcccaggt aaagtcaaag aattatacat
     7021 agaaaatggg aagacagtaa aaaaagacga catactctac acaatagatc ataccgaact
     7081 aaaaaataaa caagctttta tagaagaaga attatccagg aaaaaaacag agctaaaaaa
     7141 tcaaaacatc tttaaacaaa gcatcataga aaacaaaaac agctttaatc agcaagaaaa
     7201 agatcaagaa gttcattact acaaatatat aaaatatcaa gcagagcaag ggcagacaaa
     7261 agaaaatgta aacctaatca tcagtaaaat aaatactaca caaactatac tacaaaacac
     7321 acaaacactt ttgactgcca tagagaataa tgaaaataaa tttgaagata cagaaaacga
     7381 atactacatc aaatttcttg attacagcct taatctaaaa gacctgcaaa aagaggtaga
     7441 caagaaaaag atagaccttg aaatacaaga aaaactacac caatcaggtg ctgtatccca
     7501 aatggactat aagaatgtga aagacatgct agaaaaaatg caattagaaa aaaaacgatt
     7561 tgaaaacagc acccgattaa gccttaaaac aagcatggaa gaaaaccaaa gactgttaaa
     7621 tcagctagaa atacaattac aacaaattgc accaggaata gttgaacaaa tagaaaacca
     7681 tccagacata gcagcagcaa accatagaac agaaaatata atagcaataa atgagactat
     7741 aaaatatcta gaggcagaaa tcaaccaact acaaaataat cttaagggca taaagctaga
     7801 cattgaaaac tctattagta aagccccaat agatggacat ataaacatca tcacagacat
     7861 caaccaaggg gataatatac aagcaggaac accaatagca accattattc catatgatga
     7921 cagcaattat acagtacgaa tatatgcatc caacgaagac atcgcaaata taaacatagg
     7981 agataaagtg aaatataact tcatggcatt accctataaa gaatacggcg aattgacagg
     8041 caaaattaca agaatagcaa cagatacaaa aacaactcaa gaaggtaaca caagctacta
     8101 cctagtagag tcagatatag aaacaagagc cttaattagc tacaaaggtg aagaagctga
     8161 tataaaagta gggatggtat gtgaagccag ggtagtaacc aaaacaaaga aaatacttca
     8221 ttacttgctt gagaagatag atttaagatt gtaaagatga gtaaagtagg atgataagca
     8281 ttgctaatta gaattttaag aatgactaat ttgtattgta tttcctgcaa cacataaagc
     8341 ttgcagctat ctcaaagcaa agcaggcgat aaaacctttt gatgagagaa aaggttgtgt
     8401 aggagtaggg attataataa ataaactaaa agagcagatt tacatagttc aatattttgt
     8461 tcagaagttt tccgcggaat ggatggatga ggtattggta tttactaaag aaaagtgaat
     8521 ctgtaaaaaa tttaaaggag gaataaaaaa tgtttaaaga aatgactcaa aaagaaatga
     8581 tgatgcttga tgggggaaaa agaagaagtt ctacaagaca tgaaagaagt ggtgggtata
     8641 gtagagttac tgatgaagct agacaatctc atatcaacgt tgtcgtaggt gctgcagttt
     8701 ctgcagtttt aggtggtgct ggtggtgctg catttggtgg atctgttggg agcggagtat
     8761 tagggggtgg agtaagtgga agtatagggt ctggtatagc agatacaata gttaataagc
     8821 taaattaata atatcaagat tgtatctatc gcctattttt aaaatgagtt ataacttgaa
     8881 ttaatgtatg tattaatcat taagggagag aaatttttac tgaaatgtat aaagtaaaaa
     8941 tttctcttca acacttattc tatatttaat atgagcgaat aaaaaataat gttttttatt
     9001 taaaccaaaa gacactataa aatctttgat taggaataat ttgaaagctt gaggcgtctt
     9061 taaaattatc tctagtatac taagtaagat aggtcttgct agatatcagt atcatcggat
     9121 atgtcaaaag actatgtatt aaatagaagt ggttttaaaa taatatattg aaggagataa
     9181 caatgaaaac aagaaaatta ttattaattt atactatttt ttttgtgatt tatggttttg
     9241 gatttagctt tgttattaat tacccggatc tatattcatt acattacatg tggtttgctg
     9301 ttgttacaac aataatactg cttattagta taagactatt caaacttatt gatgatagaa
     9361 taacatgttt ggaagaaaaa ataaagatta ataaaaatac tcagaactaa aaagagtaag
     9421 aattttatcc taatgaggat tagagagact gccaagggga cggggtttct aatgaacgga
     9481 agagacgttt gaagtgcccc tccccttaac caaaaccaat atgaaacaca gtacaatagt
     9541 ggttattaga ggagatatta agtttagcta ggcacttcgt gcaggtaaat aagtaacaag
     9601 caaacagtga caaatttgac ttgatgtttt ataactataa gaattgtctt cgcaatcaag
     9661 ggtcgcaatc aaggggacgg ttctgttgat taatgattga aatttaagat tgtagatgtt
     9721 gtacagactc ttatctcaat cacttaatcg aaagaaccgt gcctgtaatt ctttaactat
     9781 gagtattgat taggggcttt gtttaattta atcaaagtat tttatgattt aataagattg
     9841 tggcattgtc cccaaaagtt atttacaaaa aacaatagct tctttattac tgtatgaaaa
     9901 tgaaatttat aaaaggaaaa agctcaactc caatagtaaa tttgcttgag cttgctgaaa
     9961 cattggggaa tgaggtggag actctactcc acctgattaa aatctcacta cgtaaatact
    10021 gtatttacgt ggaatataat atttcgtaat tagtccaaac aaaggtaact aaggagggat
    10081 acttaataat gaataagttt agcagttcgg taaaaaatgg ttttttccta tactttctga
    10141 ttgttttaag ttcaaattta ttctactttt caactcgaaa tatagggctt agtagattaa
    10201 tacgtgttct tataattcaa tactttttct acctactaat accaattacc tgtttaatgt
    10261 taaataaaaa aattattaaa aaagatttga ggctcaataa aataaactgg aagcaattta
    10321 gattaatttt tttgatttcg atattagcag tacctatatc gacttattta aacaatgtgg
    10381 tgttggttgt actaagtcta tttggggact atacaagaat tcaacggtta ataactgacg
    10441 tcacatcttt ttatactcta atagcatcaa tatttatctt tgtcataaca ccagcaatct
    10501 gtgaagaaac aatgtttcgc ggatttctta tgaatgagtt taaatcaata ggtgttagaa
    10561 aatcaattat tttaaccgca gttctattca gtatatttca tcttgatata gagtttttac
    10621 tgggggctac ttttataggg attatatttg gttatctagt acatataaca aattccctat
    10681 atgctggaat aattgcacat ggcatcttta acttgacagg atcattatta aaatttcttc
    10741 tacttaatgg aagttctgac atagctggtg atattgttat ttggaaggag atcattcctg
    10801 ttattttatt aggtataatg ccatcctgtg tatttgttgc gcttagttgg ctacttataa
    10861 aaaaattgat agaaacagtc aacaatactc cacaaaattt tgaggttgag tga
//
