LOCUS       NC_009633.1            18688 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NC_009633.1 Alkaliphilus metalliredigens QYMF, complete sequence.
ACCESSION   NC_009633
VERSION     NC_009633.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 16:10:54
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 131923
            Orig. end    :: 150611
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..189
                     /locus_tag="ctg1_125"
                     /transl_table=11
                     /translation="MSIKKMQILIFIGALIHITLSLLKFNNPLEKYKTESEIGIFLLVV
                     YLIIIFFAYKTKTKVKS"
     protocluster    1..18688
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[141198:141813](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(9276..9890)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..18688
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18688
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             292..1047
                     /locus_tag="ctg1_126"
                     /transl_table=11
                     /translation="MPRTAREKSKSGIYHVMIRGANRQEIFHDEQDCLRFLEILDRYKV
                     KTEIKIYGWCLMNNHMHLLIQEGKEELATTMKRIGVSFVGYYHQKYDTTGHLFQDRFRS
                     ENVENDEYLITVIRYIHQNPVKAGLVSKPVDWKWSSCSGYYGKKEYLQGLLDSERILGL
                     FSNDRESAIKEFRKFNEQENKDNCLDDVIITSLRDEEARLEIEKILSGINIGQIKSLPK
                     DQRDKIIREAKCIEGVKQRQLARLLGVSQ"
     PFAM_domain     328..660
                     /aSDomain="Y1_Tnp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01797.18"
                     /description="Transposase IS200 like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_126_0022"
                     /evalue="1.10E-14"
                     /label="ctg1_126"
                     /locus_tag="ctg1_126"
                     /protein_end="123"
                     /protein_start="12"
                     /score="54.7"
                     /tool="antismash"
                     /translation="IYHVMIRGANRQEIFHDEQDCLRFLEILDRYKVKTEIKIYGWCLM
                     NNHMHLLIQEGKEELATTMKRIGVSFVGYYHQKYDTTGHLFQDRFRSENVENDEYLITV
                     IRYIHQN"
     CDS             1128..1439
                     /locus_tag="ctg1_127"
                     /transl_table=11
                     /translation="MKSSENKEKWQLHINSQLSSGQTQIQWCEEQGVKIHSFRYWKNRL
                     QIKPEQAKESTGFVAIKPVTLQKVSKMRIRIGKATVEIDDDVDPILLTSVIRVLTDYV"
     CDS             1910..3511
                     /locus_tag="ctg1_128"
                     /transl_table=11
                     /translation="MKTIENSTHSITSTTEDRLAFFENELAQKEQKIEELEAKVKFYEE
                     QFRLSQAQKYGSSSEKTDPDQMSIFNEAEKFSVKLDEEPEAEEVLTKRRTGKSKSKKKY
                     EDLPIEEVHYTLSDEERQCPKCDHTLHEMKTEVRKELKIIPAQVKVVHHIKQVYACRGC
                     DAIDSDNGGTIITAPMPKPVLPGSMVSPSVLAFIMENKYNQALPLYRQEASFVNYGIDL
                     SRQNMASWIIQGAEKWLSPLYDRMHTHLKQSPVIHADESPLKVLDEKDKSQSYMWLYAT
                     AETSEYPIYLYEYQPSRAKKHPKQFLEGFTGFLQTDGYAGYNGVENVVQVGCLAHARRK
                     YTDAIKALPEGSDVSLTKANEGLSLLRKIYRLEKSFKEMEPEVRYEARIEQTQPVLDAY
                     KTWLEVEEKRTLPKSKLGQAISYSLKQWDKLAAFMKDGRIAIDNNLAERGIKPFVLGRK
                     NYLFAKSPKGATASALCYSIIETAKANKLIPFQYLTYLFEQLPNLDIEDPEALDAMLPW
                     AESLPNEVRHKTEKND"
     PFAM_domain     2039..2245
                     /aSDomain="LZ_Tnp_IS66"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13007.9"
                     /description="Transposase C of IS166 homeodomain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_128_0023"
                     /evalue="1.90E-07"
                     /label="ctg1_128"
                     /locus_tag="ctg1_128"
                     /protein_end="112"
                     /protein_start="43"
                     /score="31.8"
                     /tool="antismash"
                     /translation="EEQFRLSQAQKYGSSSEKTDPDQMSIFNEAEKFSVKLDEEPEAEE
                     VLTKRRTGKSKSKKKYEDLPIEEV"
     PFAM_domain     2267..2401
                     /aSDomain="zf-IS66"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13005.9"
                     /description="zinc-finger binding domain of transposase
                     IS66"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_128_0024"
                     /evalue="5.30E-13"
                     /label="ctg1_128"
                     /locus_tag="ctg1_128"
                     /protein_end="164"
                     /protein_start="119"
                     /score="49.3"
                     /tool="antismash"
                     /translation="ERQCPKCDHTLHEMKTEVRKELKIIPAQVKVVHHIKQVYACRGCD
                     "
     PFAM_domain     2468..3319
                     /aSDomain="DDE_Tnp_IS66"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03050.16"
                     /description="Transposase IS66 family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_128_0025"
                     /evalue="2.80E-97"
                     /label="ctg1_128"
                     /locus_tag="ctg1_128"
                     /protein_end="470"
                     /protein_start="186"
                     /score="325.7"
                     /tool="antismash"
                     /translation="SMVSPSVLAFIMENKYNQALPLYRQEASFVNYGIDLSRQNMASWI
                     IQGAEKWLSPLYDRMHTHLKQSPVIHADESPLKVLDEKDKSQSYMWLYATAETSEYPIY
                     LYEYQPSRAKKHPKQFLEGFTGFLQTDGYAGYNGVENVVQVGCLAHARRKYTDAIKALP
                     EGSDVSLTKANEGLSLLRKIYRLEKSFKEMEPEVRYEARIEQTQPVLDAYKTWLEVEEK
                     RTLPKSKLGQAISYSLKQWDKLAAFMKDGRIAIDNNLAERGIKPFVLGRKNYLFAKSPK
                     GAT"
     PFAM_domain     3338..3460
                     /aSDomain="DDE_Tnp_IS66_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13817.8"
                     /description="IS66 C-terminal element"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_128_0026"
                     /evalue="1.80E-13"
                     /label="ctg1_128"
                     /locus_tag="ctg1_128"
                     /protein_end="517"
                     /protein_start="476"
                     /score="50.6"
                     /tool="antismash"
                     /translation="SIIETAKANKLIPFQYLTYLFEQLPNLDIEDPEALDAMLPW"
     CDS             3797..5656
                     /locus_tag="ctg1_129"
                     /transl_table=11
                     /translation="MYISKSKRPNGKYFISIAKGIRDPETKKSKKIQIKGFGTHDLDSK
                     SGKKALVQAEAELKEMIRLDEASRGFENFEDFIVSMSKDKLSLKHKNIGYLPYLEIFNQ
                     LELQSFFSKMVKDSKLDYSFSDMMFYQVLGRLFNPSSKLEVATRKDDFLYDFNFVNNDN
                     IYSSLDVFSGFNKHKSKALQDGIQVINDMEILLDTVDSEAKKILETNINNTSHELEELI
                     TSYDSNFEMNENKLFKHLNKHMEKIVPERNISLAFYDCTTYYFESFDEDGFRERGMSKD
                     NKRNETQVVMGLLIDTNGIPISYRLFKGNKHELHTMEEVIDDILNNYTIKEIIIVADRG
                     LNSRANLEMIRGKGLNYIVGSKGSAVPKDLKEKKFNSSWNITSKAEAKYKSGYITSKRK
                     VSHNDETYDELIIKKYSDVYKEREMFKQDKMLERAKKNIKDFTINSTTKSKSKYYKAVD
                     NPKEKINIEIDEEKIKQEQENFGYFYIVTNKVEMNPADIMVAYKSLYKIEESFRILKTN
                     LKARPVYHFKERRIRSHFLICYLALVIQRVLEYKLEEKNVEISTHEIINGLEGFVIDEI
                     DYKVDKLYMISDKLFKSKINQDIFKIEKNVLLSNEISNIIKKM"
     PFAM_domain     4565..5428
                     /aSDomain="DDE_Tnp_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01609.23"
                     /description="Transposase DDE domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_129_0027"
                     /evalue="1.10E-18"
                     /label="ctg1_129"
                     /locus_tag="ctg1_129"
                     /protein_end="544"
                     /protein_start="256"
                     /score="67.8"
                     /tool="antismash"
                     /translation="FYDCTTYYFESFDEDGFRERGMSKDNKRNETQVVMGLLIDTNGIP
                     ISYRLFKGNKHELHTMEEVIDDILNNYTIKEIIIVADRGLNSRANLEMIRGKGLNYIVG
                     SKGSAVPKDLKEKKFNSSWNITSKAEAKYKSGYITSKRKVSHNDETYDELIIKKYSDVY
                     KEREMFKQDKMLERAKKNIKDFTINSTTKSKSKYYKAVDNPKEKINIEIDEEKIKQEQE
                     NFGYFYIVTNKVEMNPADIMVAYKSLYKIEESFRILKTNLKARPVYHFKERRIRSHFLI
                     CYLALVI"
     CDS             5778..6164
                     /locus_tag="ctg1_130"
                     /transl_table=11
                     /translation="MCVGFYAYEQIMRRIAGSYVYWYNWKYDRIGNLFQDRFKSEPVED
                     NTYFLTVLRYSHQNPIKAGVTKDIKNYKWSSYKEYLEGKGLTDREYVLEFFHKDPSIAL
                     GELVKYSDTLNEDKCLEIDENQKS"
     CDS             complement(6382..6975)
                     /locus_tag="ctg1_131"
                     /transl_table=11
                     /translation="MITILDIEIIKQNKFTILSIVIFVSALSKNIKLLIESPNEYMIWI
                     TILILFLLISKICLPFINNKKLFYKSILIVSLSIIYLIIGAMFIRYNAEHIDYEMNKEQ
                     KAGTKVRYTFYMTGRMNSPISVIKVIPIGAKGLEKHEINSRYTRDIRDSSIATTMTFVI
                     SEENIKLPTRTIVIYRALGVIPMINIRTNELAGM"
     CDS             complement(7358..8185)
                     /locus_tag="ctg1_132"
                     /transl_table=11
                     /translation="MKRIMSLIIILGILLSISTVGAASTSQYPIKELKQNNIDEYNLLY
                     QHYKEANNQALKYILENKTMEGLSDFRTSEYEMYIREHTNNKSDFSVKSADSIELINII
                     DGLIIDDTYSTIYIYSDSSFIIESMKFTDTFNDKILEATLLDISMNSADRSKTYVIENF
                     SIPTRSPIRTETSYTINLGLTGFQLNTFVDVKDSNTVDLAYHNTNGTYNLDPYVSIEAS
                     SRELDENNLSNMCFTEGMYTTKDLLWEKDHFIQKAVVLEYDKLLVTSYFYFDR"
     CDS             complement(8205..9038)
                     /locus_tag="ctg1_133"
                     /transl_table=11
                     /translation="MKKTPVLIMMLVTLFSILTIGSVSAIQDSTKEISQDVVYDYNLLQ
                     EHYERSNNKALEYILENKTIEGINTFRTSEYDLYVQGVKNNEIHINGVTTDSIELVEVI
                     DDIFIDSAYSTIYIYSDSSFIIESMKFIDTSNDKIIEATVADISVNSADSSYTYVVEDF
                     DIPNRTPIRAEAWYTVNLGLVKFQLNTFIDVEDVSTVNVAYHNTNGSYSASPTLDLVEQ
                     SSRELNDNNLSNVCFTEGLYTLRGGFNSLSDSYIQKAIVLENSRLLVTSYLYFDQ"
     CDS             complement(9276..9890)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_134"
                     /sec_met_domain="AgrB (E-value: 4.9e-40, bitscore: 135.0,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKLATYTVNKMNETITIDKEKIDFYIYGTELFIITLIKGIGLI
                     LIASILGLLTEALIFILAFSILRIQAGGIHANSFWKCFLLTDMITFTAIYLVYLIPSNS
                     MLTFQAFFSFFSILLVLYYAPVESPNKPLTSHEKRIYKDRSCFIVLIGIVITLTISWIS
                     PYHSMYGLIFSLGFFCEGITLVPAFQRRLYKLKIRKWRCLD"
     PFAM_domain     complement(9345..9869)
                     /aSDomain="AgrB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04647.17"
                     /description="Accessory gene regulator B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_134_0028"
                     /evalue="1.30E-39"
                     /label="ctg1_134"
                     /locus_tag="ctg1_134"
                     /protein_end="182"
                     /protein_start="7"
                     /score="135.5"
                     /tool="antismash"
                     /translation="YTVNKMNETITIDKEKIDFYIYGTELFIITLIKGIGLILIASILG
                     LLTEALIFILAFSILRIQAGGIHANSFWKCFLLTDMITFTAIYLVYLIPSNSMLTFQAF
                     FSFFSILLVLYYAPVESPNKPLTSHEKRIYKDRSCFIVLIGIVITLTISWISPYHSMYG
                     LIFSLGFFCEGI"
     CDS             complement(10016..10243)
                     /locus_tag="ctg1_135"
                     /transl_table=11
                     /translation="MYVNEVYLIIKILNAKPTTYTLSNESIDESFTTKKDKENHGLGLK
                     NIQTTIAQYDGLINLKDQGDTVEIQIAIPK"
     PFAM_domain     complement(10022..10228)
                     /aSDomain="HATPase_c_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF14501.8"
                     /description="GHKL domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_135_0029"
                     /evalue="7.00E-10"
                     /label="ctg1_135"
                     /locus_tag="ctg1_135"
                     /protein_end="74"
                     /protein_start="5"
                     /score="38.8"
                     /tool="antismash"
                     /translation="VYLIIKILNAKPTTYTLSNESIDESFTTKKDKENHGLGLKNIQTT
                     IAQYDGLINLKDQGDTVEIQIAIP"
     CDS             10528..10737
                     /locus_tag="ctg1_136"
                     /transl_table=11
                     /translation="MPRTAREKNKSGIYHVMIRGANRQEIFHDEQDCLRFLEILEIYKV
                     KTEIKIYDCCLMNNQANNRDGSFD"
     CDS             10787..11560
                     /locus_tag="ctg1_137"
                     /transl_table=11
                     /translation="MPRTAREKSKSGIYHVMIRGANRQEIFHDEQDCLRFLEILDRYKV
                     KTEIKIYGWCLMNNHMHLLIQEGKEELATTMKRIGVSFVGYYHQKYDTTGHLFQDRFRS
                     ENVESDEYLITVIRYIHQNPVKAGLVSKPVDWKWSSCSGYYGKKEYLQGLLDSERILGL
                     FSNDRESAIKEFRKFNEQENKDNCLDDVIITSLRDEEARLEIEKILSGINIAQIKSLPK
                     DQRDKIIREAKCIEGVKQRQLARLLGVSQTMISIA"
     PFAM_domain     10823..11155
                     /aSDomain="Y1_Tnp"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01797.18"
                     /description="Transposase IS200 like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_137_0030"
                     /evalue="1.70E-14"
                     /label="ctg1_137"
                     /locus_tag="ctg1_137"
                     /protein_end="123"
                     /protein_start="12"
                     /score="54.1"
                     /tool="antismash"
                     /translation="IYHVMIRGANRQEIFHDEQDCLRFLEILDRYKVKTEIKIYGWCLM
                     NNHMHLLIQEGKEELATTMKRIGVSFVGYYHQKYDTTGHLFQDRFRSENVESDEYLITV
                     IRYIHQN"
     CDS             11669..12190
                     /locus_tag="ctg1_138"
                     /transl_table=11
                     /translation="MYKRIILIIAALFIFAACGEKLQYSVPSLEQVNEFISDNSVNALA
                     IKEAEDFTIVLYENENGFGHYVLHRDQNNKLYDGKVIAMRHKDYQQNTLSLGGVASGKN
                     PFVTVIINDDNVLDKATELEILFTDGVKVKEPIDNKGIIIIHTNNESDKIINYLKVTIY
                     DSDMNILYEK"
     CDS             12413..12781
                     /gene_functions="regulatory (smcogs) SMCOG1058:ArsR family
                     transcriptional regulator (Score: 84.7; E-value: 5.4e-26)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_139"
                     /transl_table=11
                     /translation="MEKERITMDTCNCTIIHEDIVNRVKESMPQEEKLYDLAELFKVFG
                     DTTRIKIIYALFESEMCVCDIAALLGMNQSAISHQLRVLKQAGLAKYRREGKVVYYSLD
                     DEHVKNIFDQGYTHIAHK"
     PFAM_domain     12548..12688
                     /aSDomain="HTH_5"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01022.22"
                     /description="Bacterial regulatory protein, arsR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_139_0031"
                     /evalue="3.50E-20"
                     /label="ctg1_139"
                     /locus_tag="ctg1_139"
                     /protein_end="92"
                     /protein_start="45"
                     /score="71.7"
                     /tool="antismash"
                     /translation="DTTRIKIIYALFESEMCVCDIAALLGMNQSAISHQLRVLKQAGLA
                     KY"
     CDS             12795..15161
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 478.6; E-value:
                     5.9e-145)"
                     /gene_kind="other"
                     /locus_tag="ctg1_140"
                     /transl_table=11
                     /translation="MSYVSHVIKKELILEGMDCAGCTSKIEVAIAKLVGVKEVSLNFVT
                     KTLTIEIDDESKMESVVSAAKDIVNQFEPHVIVKEKMIDKVSKKALVLKGLSCVSCATK
                     IEDKVKELKGVHSVYMDFTSEKLVIEAKTHDWHRITKEVTAIVKHIESDVEVIDESRKK
                     DEQGHSHGGGDNKMELIRLGIGAILYAIALAFQMSDSIEFVLYFISYLLIGGEVLLKAG
                     RNIRRGQIFDENFLMSIATIGAFAIGEFPEGVAVMLFYQIGEFFQGLAVNRSRKSIGAL
                     MDIRPDYANLKVGNDVKKVSPEEVTVGDHILVKPGEKVPLDGVVIEGQSMVDTSALTGE
                     SVPREVEVDSNVLGGFINKNGVLTIKVSKEFGESTVSKILELVENASSKKAPTENFITK
                     FARYYTPVVVFVALALAIIPPLVIDGATFSEWIYRALVFLVISCPCALVISIPLGFFGG
                     IGGASKNGILIKGGNYLEALNSVDIVVFDKTGTLTKGVFKVMEINVEQNISKEELLEYA
                     AYAESYSNHPISTSILKAYGKEVNKEEIESYNEISGHGIKIKVKDKEILAGNIKLMDSE
                     KIAYEPVEAIGTIVYVAINGKLAGSIIISDEIKEDSQRAIKELKAIGVKKIVMLTGDNK
                     QVGIKVAKQLGIDEVHTELLPDEKVEKLEQLDRQKSPKGKLVFVGDGINDAPVLARADI
                     GVAMGGLGSDAAIEAADVVLMTDEPMKLVSAIKIAKRTKRIVWQNIIFAFGVKGIVLLL
                     GAGGLATMWEAVFADVGVALIAVFNAMRVLNVKNL"
     PFAM_domain     12831..12971
                     /aSDomain="HMA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00403.28"
                     /description="Heavy-metal-associated domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_140_0032"
                     /evalue="8.30E-11"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="59"
                     /protein_start="12"
                     /score="42.2"
                     /tool="antismash"
                     /translation="ILEGMDCAGCTSKIEVAIAKLVGVKEVSLNFVTKTLTIEIDDESK
                     ME"
     PFAM_domain     13074..13208
                     /aSDomain="HMA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00403.28"
                     /description="Heavy-metal-associated domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_140_0033"
                     /evalue="4.40E-09"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="138"
                     /protein_start="93"
                     /score="36.7"
                     /tool="antismash"
                     /translation="KGLSCVSCATKIEDKVKELKGVHSVYMDFTSEKLVIEAKTHDWHR
                     "
     aSDomain        13494..15140
                     /aSDomain="TIGR01525"
                     /aSTool="tigrfam"
                     /description="ATPase-IB_hvy: heavy metal translocating
                     P-type ATPase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_140_0008"
                     /evalue="3.20E-175"
                     /identifier="TIGR01525"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="782"
                     /protein_start="233"
                     /score="582.1"
                     /tool="antismash"
                     /translation="NFLMSIATIGAFAIGEFPEGVAVMLFYQIGEFFQGLAVNRSRKSI
                     GALMDIRPDYANLKVGNDVKKVSPEEVTVGDHILVKPGEKVPLDGVVIEGQSMVDTSAL
                     TGESVPREVEVDSNVLGGFINKNGVLTIKVSKEFGESTVSKILELVENASSKKAPTENF
                     ITKFARYYTPVVVFVALALAIIPPLVIDGATFSEWIYRALVFLVISCPCALVISIPLGF
                     FGGIGGASKNGILIKGGNYLEALNSVDIVVFDKTGTLTKGVFKVMEINVEQNISKEELL
                     EYAAYAESYSNHPISTSILKAYGKEVNKEEIESYNEISGHGIKIKVKDKEILAGNIKLM
                     DSEKIAYEPVEAIGTIVYVAINGKLAGSIIISDEIKEDSQRAIKELKAIGVKKIVMLTG
                     DNKQVGIKVAKQLGIDEVHTELLPDEKVEKLEQLDRQKSPKGKLVFVGDGINDAPVLAR
                     ADIGVAMGGLGSDAAIEAADVVLMTDEPMKLVSAIKIAKRTKRIVWQNIIFAFGVKGIV
                     LLLGAGGLATMWEAVFADVGVALIAVFNAMRV"
     aSDomain        13494..15143
                     /aSDomain="TIGR01512"
                     /aSTool="tigrfam"
                     /description="ATPase-IB2_Cd: cadmium-translocating P-type
                     ATPase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_140_0009"
                     /evalue="1.10E-159"
                     /identifier="TIGR01512"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="783"
                     /protein_start="233"
                     /score="530.3"
                     /tool="antismash"
                     /translation="NFLMSIATIGAFAIGEFPEGVAVMLFYQIGEFFQGLAVNRSRKSI
                     GALMDIRPDYANLKVGNDVKKVSPEEVTVGDHILVKPGEKVPLDGVVIEGQSMVDTSAL
                     TGESVPREVEVDSNVLGGFINKNGVLTIKVSKEFGESTVSKILELVENASSKKAPTENF
                     ITKFARYYTPVVVFVALALAIIPPLVIDGATFSEWIYRALVFLVISCPCALVISIPLGF
                     FGGIGGASKNGILIKGGNYLEALNSVDIVVFDKTGTLTKGVFKVMEINVEQNISKEELL
                     EYAAYAESYSNHPISTSILKAYGKEVNKEEIESYNEISGHGIKIKVKDKEILAGNIKLM
                     DSEKIAYEPVEAIGTIVYVAINGKLAGSIIISDEIKEDSQRAIKELKAIGVKKIVMLTG
                     DNKQVGIKVAKQLGIDEVHTELLPDEKVEKLEQLDRQKSPKGKLVFVGDGINDAPVLAR
                     ADIGVAMGGLGSDAAIEAADVVLMTDEPMKLVSAIKIAKRTKRIVWQNIIFAFGVKGIV
                     LLLGAGGLATMWEAVFADVGVALIAVFNAMRVL"
     aSDomain        13587..15071
                     /aSDomain="TIGR01494"
                     /aSTool="tigrfam"
                     /description="ATPase_P-type: HAD ATPase, P-type, family IC"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_140_0010"
                     /evalue="1.10E-75"
                     /identifier="TIGR01494"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="759"
                     /protein_start="264"
                     /score="252.8"
                     /tool="antismash"
                     /translation="FFQGLAVNRSRKSIGALMDIRPDYANLKVGNDVKKVSPEEVTVGD
                     HILVKPGEKVPLDGVVIEGQSMVDTSALTGESVPREVEVDSNVLGGFINKNGVLTIKVS
                     KEFGESTVSKILELVENASSKKAPTENFITKFARYYTPVVVFVALALAIIPPLVIDGAT
                     FSEWIYRALVFLVISCPCALVISIPLGFFGGIGGASKNGILIKGGNYLEALNSVDIVVF
                     DKTGTLTKGVFKVMEINVEQNISKEELLEYAAYAESYSNHPISTSILKAYGKEVNKEEI
                     ESYNEISGHGIKIKVKDKEILAGNIKLMDSEKIAYEPVEAIGTIVYVAINGKLAGSIII
                     SDEIKEDSQRAIKELKAIGVKKIVMLTGDNKQVGIKVAKQLGIDEVHTELLPDEKVEKL
                     EQLDRQKSPKGKLVFVGDGINDAPVLARADIGVAMGGLGSDAAIEAADVVLMTDEPMKL
                     VSAIKIAKRTKRIVWQNIIFAFGVKGIVLLLGAGGLA"
     PFAM_domain     13647..14186
                     /aSDomain="E1-E2_ATPase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00122.22"
                     /description="E1-E2 ATPase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_140_0034"
                     /evalue="1.90E-47"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="464"
                     /protein_start="284"
                     /score="161.3"
                     /tool="antismash"
                     /translation="RPDYANLKVGNDVKKVSPEEVTVGDHILVKPGEKVPLDGVVIEGQ
                     SMVDTSALTGESVPREVEVDSNVLGGFINKNGVLTIKVSKEFGESTVSKILELVENASS
                     KKAPTENFITKFARYYTPVVVFVALALAIIPPLVIDGATFSEWIYRALVFLVISCPCAL
                     VISIPLGFFGGIGGASK"
     PFAM_domain     14235..14873
                     /aSDomain="Hydrolase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00702.28"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_140_0035"
                     /evalue="7.50E-37"
                     /label="ctg1_140"
                     /locus_tag="ctg1_140"
                     /protein_end="693"
                     /protein_start="480"
                     /score="127.7"
                     /tool="antismash"
                     /translation="VDIVVFDKTGTLTKGVFKVMEINVEQNISKEELLEYAAYAESYSN
                     HPISTSILKAYGKEVNKEEIESYNEISGHGIKIKVKDKEILAGNIKLMDSEKIAYEPVE
                     AIGTIVYVAINGKLAGSIIISDEIKEDSQRAIKELKAIGVKKIVMLTGDNKQVGIKVAK
                     QLGIDEVHTELLPDEKVEKLEQLDRQKSPKGKLVFVGDGINDAPVLARAD"
     CDS             15269..16525
                     /locus_tag="ctg1_141"
                     /transl_table=11
                     /translation="MSIGYACLTVGVENTDQKSCMLKNASESRLSEIVAYNLSALENII
                     DYNIKNQIKLFRISSDLIPFGSSPMNTLHWWDVYRSDFSKIGEKIKKSGMRVSMHPGQY
                     TVLNSPREEVVERAIQDLNYHARVLDCLGVGPEHKIVLHIGGIYDDKKEAMDRFIRNYQ
                     SLEEAVKKRLVIENDDKSYTISDVLEIGAILNIPVIFDNLHNEINPSDQERDELYWIGA
                     CRKTWEEKDGNQKIHYSQQNPEKRAGSHSESIGINEFMVFYQKIKRDDLDMMLEVKDKN
                     LSAVKCINSTSTQKKIKALELEWSKYKYTILETSPVNYLEIRKILKDKDGYPAISFYTL
                     VEEALQKERTIENAVNAAQHVWGYFKDVASEKEKQAFLKNMDKFIKKETSIRSIKRNLW
                     KLAVKYKEEYLLSSYYFVL"
     PFAM_domain     15278..16057
                     /aSDomain="UvdE"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03851.16"
                     /description="UV-endonuclease UvdE"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_141_0036"
                     /evalue="1.10E-72"
                     /label="ctg1_141"
                     /locus_tag="ctg1_141"
                     /protein_end="263"
                     /protein_start="3"
                     /score="244.7"
                     /tool="antismash"
                     /translation="GYACLTVGVENTDQKSCMLKNASESRLSEIVAYNLSALENIIDYN
                     IKNQIKLFRISSDLIPFGSSPMNTLHWWDVYRSDFSKIGEKIKKSGMRVSMHPGQYTVL
                     NSPREEVVERAIQDLNYHARVLDCLGVGPEHKIVLHIGGIYDDKKEAMDRFIRNYQSLE
                     EAVKKRLVIENDDKSYTISDVLEIGAILNIPVIFDNLHNEINPSDQERDELYWIGACRK
                     TWEEKDGNQKIHYSQQNPEKRAGSHSESIGINEFMVFY"
     aSDomain        15278..16126
                     /aSDomain="TIGR00629"
                     /aSTool="tigrfam"
                     /description="uvde: UV damage endonuclease UvdE"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_141_0011"
                     /evalue="1.70E-64"
                     /identifier="TIGR00629"
                     /label="ctg1_141"
                     /locus_tag="ctg1_141"
                     /protein_end="286"
                     /protein_start="3"
                     /score="216.2"
                     /tool="antismash"
                     /translation="GYACLTVGVENTDQKSCMLKNASESRLSEIVAYNLSALENIIDYN
                     IKNQIKLFRISSDLIPFGSSPMNTLHWWDVYRSDFSKIGEKIKKSGMRVSMHPGQYTVL
                     NSPREEVVERAIQDLNYHARVLDCLGVGPEHKIVLHIGGIYDDKKEAMDRFIRNYQSLE
                     EAVKKRLVIENDDKSYTISDVLEIGAILNIPVIFDNLHNEINPSDQERDELYWIGACRK
                     TWEEKDGNQKIHYSQQNPEKRAGSHSESIGINEFMVFYQKIKRDDLDMMLEVKDKNLSA
                     VK"
     PFAM_domain     16190..16516
                     /aSDomain="DUF1722"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08349.13"
                     /description="Protein of unknown function (DUF1722)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_141_0037"
                     /evalue="1.50E-25"
                     /label="ctg1_141"
                     /locus_tag="ctg1_141"
                     /protein_end="416"
                     /protein_start="307"
                     /score="89.9"
                     /tool="antismash"
                     /translation="KYTILETSPVNYLEIRKILKDKDGYPAISFYTLVEEALQKERTIE
                     NAVNAAQHVWGYFKDVASEKEKQAFLKNMDKFIKKETSIRSIKRNLWKLAVKYKEEYLL
                     SSYYF"
     CDS             16826..17200
                     /gene_functions="regulatory (smcogs) SMCOG1136:GntR family
                     transcriptional regulator (Score: 64.8; E-value: 1.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_142"
                     /transl_table=11
                     /translation="MEFNNSKPIYLQIIDYIKKQLIRGELKGGDKISSQREFAQQMKVN
                     PNTVQRAYREMESMQLVETIRGQGTFICNQEEMLAVIQEEMAGDLLRHFIEEMYSLGYS
                     KEAMVQLIEKWKTEVREEEK"
     PFAM_domain     16853..17041
                     /aSDomain="GntR"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00392.23"
                     /description="Bacterial regulatory proteins, gntR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_142_0038"
                     /evalue="5.40E-14"
                     /label="ctg1_142"
                     /locus_tag="ctg1_142"
                     /protein_end="72"
                     /protein_start="9"
                     /score="51.7"
                     /tool="antismash"
                     /translation="YLQIIDYIKKQLIRGELKGGDKISSQREFAQQMKVNPNTVQRAYR
                     EMESMQLVETIRGQGTFI"
     CDS             17197..17898
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 146.3; E-value:
                     2.1e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_143"
                     /transl_table=11
                     /translation="MIEFKGVTKKFGSTIAVDNVTMTFPKGKIIGLLGPNGSGKSTTLK
                     MIASLNKPDQGEITIDGKSPSKETRETLAYLPEIDYLYPWMTIEGAGKFMKSFYDDWNE
                     EKFQSLMKFLNLEPQMIIKKISKGMRAKAKLLLVFSRNAKLVLLDEPLSGIDIFTRDQI
                     IDTIIQDYCEGEQTIILSTHEIHEVESLLDYVVFMHQGTILRQGEAEDLRSEENKSLVE
                     LMKEVYRNENI"
     PFAM_domain     17245..17652
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_143_0039"
                     /evalue="3.10E-25"
                     /label="ctg1_143"
                     /locus_tag="ctg1_143"
                     /protein_end="152"
                     /protein_start="16"
                     /score="89.4"
                     /tool="antismash"
                     /translation="VDNVTMTFPKGKIIGLLGPNGSGKSTTLKMIASLNKPDQGEITID
                     GKSPSKETRETLAYLPEIDYLYPWMTIEGAGKFMKSFYDDWNEEKFQSLMKFLNLEPQM
                     IIKKISKGMRAKAKLLLVFSRNAKLVLLDEPL"
     CDS             17885..18688
                     /locus_tag="ctg1_144"
                     /transl_table=11
                     /translation="MKTSRVGMIYSLYKKELVAAKNELLMIMTFILGANAFLFYKHQTG
                     WPVEASFIFSLFLLLFVVATTFFRAFSVVRNEWKENTVYLVMSLPITGVDVFLSKLLAL
                     LTQLIGLSIIALIGASLFIPIIPEVSYVLEQIQMEFTSVRLIWNALKIGLLGILGMNQA
                     IIFAFFSAVVGKLFKKFSGLITLITFIGISMINSKFIDWIGNFFIDQGMGERIESQLMG
                     LDVTMMTAMETMLNVYTLLFTIITVVTSAGVFFATAALYDRKVEL"
ORIGIN
        1 atgagtatta aaaaaatgca aattttaatc tttattggag cgttaataca tataacactt
       61 tctttattaa aattcaacaa cccacttgaa aaatacaaaa ccgaaagtga gataggtata
      121 ttccttttag ttgtatattt aattattata ttttttgcat ataaaacaaa aacaaaagtt
      181 aaaagttaac cgaccggaaa taataggtgg aaagaaataa tagggacggt tcttttgatt
      241 aagcaatgat aaagtagtat aattaggaaa aaaggtaaag gagcaatcaa tatgccacga
      301 actgccagag agaaaagcaa aagcggtata tatcatgtga tgattagagg agcaaataga
      361 caggagatat ttcatgatga gcaggactgt ctaagatttc ttgaaatatt agacagatat
      421 aaagtgaaga cagaaattaa gatatatggt tggtgcttga tgaataatca catgcattta
      481 ctcattcaag aaggtaaaga ggaacttgcg acaactatga agagaatagg tgtaagcttt
      541 gtagggtatt accatcagaa atatgataca acagggcatt tgtttcaaga caggtttaga
      601 agtgagaatg tggaaaatga tgaatatctg ataacagtaa tccggtatat acatcaaaat
      661 ccagtaaaag ctggacttgt aagtaagcct gtagattgga agtggagtag ttgttcagga
      721 tactatggaa agaaagaata tctccaagga ctattagata gtgagagaat actaggacta
      781 ttttcaaatg atagagagag tgcaataaaa gaatttagga aatttaatga acaagaaaat
      841 aaagataatt gtctggatga tgttatcatt acaagtctta gagatgaaga agcaaggtta
      901 gaaattgaga agatactatc aggaattaat atagggcaaa taaagagttt gccaaaagat
      961 caaagagata agataattag agaggctaaa tgtatagagg gtgtaaagca gcgtcaattg
     1021 gcgaggcttt taggggtttc acagtaagcg taaagcctag tacacatttt ctctcacaaa
     1081 aagttttgat ataatcatct cataaattgt gaaatgaggt gatgacaatg aagtctagtg
     1141 agaataaaga aaaatggcag ttacatataa actcgcaact ttctagcgga cagacacaaa
     1201 ttcagtggtg tgaagaacaa ggtgtaaaaa tccatagctt cagatactgg aagaaccgct
     1261 tacagattaa gcctgagcaa gctaaagaaa gtactggatt tgtagccatt aaaccagtga
     1321 cgctacagaa ggtatcaaaa atgcgtattc gtataggtaa agccaccgtg gaaatcgatg
     1381 atgatgtaga ccctatactt ctcacctcag tgataagggt acttacagat tatgtttaag
     1441 tcccattcat cttaccaggt atatctggct gtaggctcta cggatcttcg taattatgag
     1501 aagtatttaa ttatgggaag cttcccataa tcgaaaagcc attgatggct tgtcactcat
     1561 cgttcaagag aaatttaagc tggacccatt ttctcggagt ctgtttgtat tttgtaacaa
     1621 aaaacgagat aagattaaag ttcttgaatg ggatacaacc ggtttctggc ttcactataa
     1681 gcgacttgaa aaagatgttt tccagtggcc agaagtgaca gataacactc atgtggaagt
     1741 cgatgaacga gcttttagat ggctacttga tgggctgagt atcagagaac gccatgcaca
     1801 taaaaccata gaagaacgac aaattatatg agccttaaaa cattgatttt actgtgtttt
     1861 agggctttct ttagtggtaa aatctcacga aaaatgatat aatactatta tgaaaactat
     1921 tgaaaattca actcatagca taacaagtac aactgaagat agattagctt tctttgagaa
     1981 tgaacttgcc caaaaagaac aaaaaataga agaacttgaa gcaaaagtga aattctacga
     2041 agagcagttc cgcttaagtc aggcgcaaaa atatggatcg tccagtgaaa aaacggaccc
     2101 tgatcagatg tcgattttta atgaagccga aaaattctcg gttaaactcg atgaagaacc
     2161 tgaagctgaa gaggtattaa caaagcgacg aactggtaaa tctaaaagta aaaagaagta
     2221 tgaggatctt cctattgaag aagttcatta tactctttcg gatgaagaac gccagtgtcc
     2281 taagtgtgat catactttgc acgagatgaa aactgaagtt cgaaaagaac tgaaaatcat
     2341 cccagcacag gtaaaagtgg tccaccacat caaacaggtc tatgcttgta gggggtgtga
     2401 tgccattgat agtgataatg gtggtaccat cattactgca cctatgccca aacctgtcct
     2461 tcctggcagc atggtatcgc catcagtgct tgcatttatc atggaaaaca agtacaacca
     2521 ggcccttccc ctttatagac aggaagcttc ttttgtaaac tatggaattg atctatctcg
     2581 tcaaaatatg gccagttgga ttattcaagg tgctgaaaaa tggttgagtc ccttgtatga
     2641 tagaatgcat acgcatttaa aacaatcacc agtaatacat gctgatgaaa gccccctaaa
     2701 agtgcttgat gaaaaggata aaagtcaaag ctatatgtgg ctttatgcaa cggctgaaac
     2761 cagtgaatat ccaatatatc tttatgaata ccagccttcg agagctaaga aacatccaaa
     2821 gcaattttta gaaggattca caggtttcct tcagaccgat ggctacgctg gatataacgg
     2881 tgttgaaaat gtggttcagg ttgggtgcct tgctcatgct cggcggaaat acaccgacgc
     2941 cattaaagcg cttcccgaag ggtcggatgt aagcttaacc aaagccaacg aagggctctc
     3001 gcttttaaga aagatttaca ggcttgagaa atcctttaaa gagatggagc cagaggtgcg
     3061 ttatgaagcg agaatcgagc aaactcaacc agttttagat gcttataaaa cctggcttga
     3121 agtcgaggaa aaaagaacgc ttcctaaaag caagctaggc caagccataa gctattctct
     3181 aaaacagtgg gataagctag ctgcttttat gaaagatgga cgcattgcca tcgataataa
     3241 tttagccgaa cgaggaatta aacccttcgt cctaggaaga aaaaactacc tttttgctaa
     3301 gtcaccgaaa ggtgcaacgg ctagtgccct ctgctattct attattgaaa cggcaaaagc
     3361 caacaaactg attccttttc agtatttaac atatttgttt gaacagcttc caaacctgga
     3421 tattgaagat ccagaggcct tggacgctat gttgccatgg gcagaatcct tacctaatga
     3481 ggtcagacat aaaacagaaa agaatgatta aagataagcc gtttacctta actgggtaag
     3541 cggtattttt atggtatcaa actttactgg acttaaccat gtgtgttggc ttttacgctt
     3601 acgaacaaat aatgcggcgt attgcaggaa gttatgtcta ttcctgactt cagaacataa
     3661 attcagaaca aatgatgagt aaatgtttaa atttgaacat ttctcattat ttttttgttt
     3721 atttacgccc acgacttgtc gtggtgaata atatgatgta taatgtagtt agagggattt
     3781 tatggaggga ttgtgcatgt atattagtaa atctaaaaga ccaaatggta agtatttcat
     3841 atcaattgct aaggggatta gagatcctga aactaagaaa tcaaaaaaaa ttcagattaa
     3901 aggttttggt actcatgatt tggattctaa atcaggtaag aaagctcttg tgcaagctga
     3961 agctgagcta aaagaaatga ttagactaga tgaagcttct cgaggatttg aaaactttga
     4021 agattttatt gtatccatgt caaaagataa gctttctctt aagcataaaa atattggcta
     4081 tctaccatac ttagaaatct ttaaccaatt ggaattacaa agtttctttt ctaagatggt
     4141 caaagactct aaacttgatt attcttttag cgatatgatg ttctatcaag tacttggtag
     4201 attattcaat ccttctagta agcttgaagt agctactaga aaggatgatt tcctgtatga
     4261 ttttaatttt gtaaataacg ataatattta ttcctctttg gatgtttttt ctggatttaa
     4321 taaacataaa tctaaagcgt tacaagatgg cattcaagtc ataaacgata tggagattct
     4381 cttagatacc gttgattcag aggctaaaaa aatattagaa actaacataa acaatacctc
     4441 tcacgaatta gaagaactaa taacgtctta tgatagtaat tttgaaatga atgaaaacaa
     4501 acttttcaaa catctcaata aacatatgga aaagattgtt ccagaaagaa atatatcttt
     4561 agccttttat gactgcacaa cctattactt tgagtctttt gatgaagacg gttttagaga
     4621 aagaggcatg agtaaggata ataaaagaaa tgaaacacaa gtggttatgg gtttattaat
     4681 agacacaaat ggcatcccta tttcctatag gcttttcaaa ggcaacaaac atgaattaca
     4741 taccatggaa gaggtcattg acgatatatt aaataattac accataaaag aaattattat
     4801 cgttgctgac agaggcttaa attcaagggc taacttagaa atgatccgtg gcaaagggct
     4861 taactacatt gtaggttcta agggcagtgc agtgcctaaa gatctaaaag agaagaaatt
     4921 caattcatct tggaacatca cttctaaagc cgaggctaaa tataaaagcg gctatatcac
     4981 cagtaaaaga aaagtgagtc acaatgatga aacctatgat gaattaatca taaaaaaata
     5041 ttcagatgtc tacaaagaac gggagatgtt taaacaagat aaaatgcttg aaagagcgaa
     5101 aaaaaatata aaagatttta caattaattc aacaactaaa tctaaaagca agtattacaa
     5161 agctgttgat aatcctaaag agaaaataaa cattgagatc gatgaagaaa aaattaaaca
     5221 agaacaagag aatttcggat atttttacat cgttaccaat aaagtagaga tgaatccagc
     5281 agatataatg gtggcttata aatccctgta taaaattgaa gagtccttca gaatattaaa
     5341 aacaaattta aaagcaagac ctgtgtatca ctttaaagaa cgaagaatcc ggtcacattt
     5401 tttaatttgt tatttggcct tagtcatcca gagagtatta gagtataaat tagaagagaa
     5461 aaacgttgaa atatctaccc atgaaataat caatggtcta gaagggtttg ttatagatga
     5521 gattgattac aaagtagaca aattatatat gatctcagac aaattattta agagcaaaat
     5581 aaaccaagac atatttaaaa ttgaaaagaa tgttctactg agtaatgaaa tctccaatat
     5641 aattaaaaag atgtagtgag tgcaaaacaa aaataaaaag tactgaaacc tctgtaaaca
     5701 gatggcttca gcacttttta ttatgaatga tgttccgaag tcaggtttta tggtatcaaa
     5761 ctttactgga cttaaccatg tgtgttggct tttacgctta cgaacaaata atgcggcgta
     5821 ttgcaggaag ttatgtctat tggtacaact ggaaatatga ccgaataggt aatttgtttc
     5881 aggatagatt taaaagtgaa cctgtagaag ataatacata ttttttaact gtattgagat
     5941 atagtcatca aaatccaata aaagcaggtg taacaaaaga cattaagaat tacaaatgga
     6001 gcagttataa agaatatctg gaaggaaaag ggctaacaga cagagaatat gtattggaat
     6061 tctttcataa agatccttca atcgctcttg gtgaacttgt aaagtattca gatacattaa
     6121 atgaggataa gtgcttagaa attgatgaga accaaaaaag ttaaaggatg atgatttaag
     6181 agaagttatt gataatacat ataaaataaa agcagccatg attggaaacg agcctagaga
     6241 aatgatggag agaatattaa aggaaatatt gagcattgag ggtgtatcta caaggcagct
     6301 ttcgagagtt acgggggtat ctgcaaatat tatctggagg ctatgaagcg ataaccccgt
     6361 cccctcgtct ttcccctcgt cttacatccc cgctaattca ttcgttctta tatttatcat
     6421 tggaattact cctagagctc tgtatataac aatcgtcctc gttggcaatt ttatattttc
     6481 ttcgctaata acaaatgtca tagttgttgc aatactacta tctcggatgt ctctagtata
     6541 tctactgttt atctcgtgtt tttccaaacc tttagcacca attgggatca cttttattac
     6601 tgaaattggt gaattcattc tgcctgtcat ataaaacgta tatcttacct ttgtcccagc
     6661 tttttgttct ttattcattt cataatctat atgctcagca ttatatctaa taaacattgc
     6721 ccctatgatt aaataaatga tacttaaaga gactattaat atactcttat agaaaagttt
     6781 tttgttgtta ataaacggca aacaaatttt gctaattaat aaaaaaagta ttaatatagt
     6841 aatccatatc atgtattcat tagggctttc aataagaagt tttatattct tagataaagc
     6901 acttacaaag ataacaattg ataatatagt gaacttattt tgtttaatga tttctatatc
     6961 taagattgta atcatctcct ctattgatat attttattta cataattttt aatacaaaaa
     7021 ttacaatagc aaattgaact gatttacaaa ctgtaataat ttggatattt agttatatag
     7081 aacttctctt aattgatctt caaatgattc atcaggagtt aggtagccta agatttttct
     7141 tggtaaagtg gtcttctgtc aagaaaacgg acaataaaaa cttgatatat tcttgaatcg
     7201 attggataag atttaaaaca agggctccag cacagttgcc tcagtaaaaa ctaaaggagt
     7261 tcaaagaaaa taggagaagc cgctccattt ttgtgtctat tttattgggg aagattagac
     7321 cacactgata tcagtgtggt ctttaactat ttttatacta acgatcgaaa taaaaataag
     7381 aagttaccaa aagcttgtcg tattctaata caacagcctt ttgtataaaa tgatctttct
     7441 cccacagaag atcttttgta gtatacatgc cttcagtaaa acacatattg cttaagttgt
     7501 tttcgtctaa ttctctagaa gatgcttcta tgcttacata aggatctaaa ttgtacgtac
     7561 catttgtatt atggtaagct aaatcaactg tattagaatc tttcacatca acaaaagtat
     7621 tcaattgaaa ccctgtcaac cctaggttta tagtataact tgtctctgtt cttataggac
     7681 ttctagtcgg tatactaaaa ttctcaataa catatgtttt ggaacgatct gctgaattca
     7741 ttgaaatatc aagtagagtt gcctcaagaa tcttatcatt aaatgtatca gtgaacttca
     7801 tactctcaat gataaaactg ctatcagaat aaatatagat agttgaatat gtatcatcaa
     7861 taattaagcc gtctataata tttattaact caatactatc tgctgatttg acgctaaaat
     7921 ctgacttatt atttgtatgt tcccgtatat acatctcata ttctgaagtc ctaaaatcac
     7981 ttagcccttc catagtttta ttctctaaaa tatatttaag cgcttgatta tttgcctctt
     8041 tataatgttg ataaagtaaa ttatactcat caatattatt ctgctttagc tcttttattg
     8101 gatattgtga tgtgcttgcc gctcctacag ttgaaatact caataatatc ccaagtatga
     8161 ttattaagct cattattctt ttcatttact aaccctcctt taaattactg atcaaaataa
     8221 agataagaag ttactaaaag gcggctattt tctaatacaa ttgccttttg tatataactg
     8281 tcacttaagc tgttaaaacc acctcttaaa gtgtacagtc cttcagtaaa gcacacgtta
     8341 cttaaattat tatcatttaa ttctctagaa gattgttcca ccaagtccag agtaggcgaa
     8401 gcactatatg acccatttgt attgtgatac gctacattaa ccgtgcttac atcttctaca
     8461 tcgataaaag tatttaattg gaacttgact agtcctaggt tcaccgtata ccatgcttct
     8521 gccctaattg gagttctatt ggggatatca aaatcttcaa caacatatgt gtatgaagaa
     8581 tctgctgaat tcacagaaat atcggctaca gttgcttcaa tgattttatc gttagatgtg
     8641 tctataaact tcatactttc aattataaaa ctactatcag agtaaatgta tatagtagaa
     8701 tatgcactat caataaatat atcatctata acttctacta actcgatgct atctgtcgtt
     8761 actccattta tatgaatctc attattttta accccttgta catacagatc atattctgaa
     8821 gttctaaaag tgtttattcc ttctatcgtt ttattttcta aaatatattc aagtgcttta
     8881 ttgtttgacc tttcataatg ttcttgaagc aaattatagt catacacaac atcctgactt
     8941 atttctttgg tagagtcttg tattgcactt accgatccga tagttaaaat actaaatagc
     9001 gttacaagca tcatgattaa aacaggcgtt tttttcattt gttgacactc ctctcaaatt
     9061 attaacttat gcaagaattg cttttaaata tctaaaaaag ctacttgctg tgtagtaata
     9121 gatatccaat aacttttacc aagtaaattc accctattct ttcttttgcg gaaacttcgg
     9181 ctgatacaaa aatccaatac aattgatatt actgccaact tcagcgaatg caactacaat
     9241 aacagctaac caactcattg caataccagt aaacttcaat ccaaacacct ccactttctt
     9301 atttttagtt tataaagtct tctttgaaat gctggcacca aagtaatgcc ttcgcagaag
     9361 aaacctaatg aaaaaatcaa tccatacatc gaatgataag gacttatcca acttattgtt
     9421 aaagtaatta cgattccaat taatactata aaacaacttc tatctttgta tatcctcttt
     9481 tcatgagatg tcaaaggctt gttaggagat tcaacaggag cataatagag aactaacagt
     9541 atagaaaaaa acgaaaaaaa agcttgaaaa gtcagcatag agttactagg tattaaatat
     9601 actaaataaa tagcggtaaa tgtaatcata tctgttaaca agaaacattt ccaaaaagaa
     9661 ttagcatgga ttcctcctgc ttgaatcctc aaaatactaa aggctaaaat aaatattaga
     9721 gcttctgtca ataatccaag aatcgaggcg attaaaatta atcctatacc ttttattaat
     9781 gtaattataa ataactcagt tccatagata taaaaatcta ttttttcctt gtcaatggta
     9841 attgtctcat tcattttatt cacggtgtat gtggcaagtt tattaatcat tttcatcttc
     9901 cttaactttt aaacacaata tagcatgtaa gcagttttaa aagcaataca tatagcataa
     9961 gtggtgggaa aaacggccta aatagcaaaa gatgacctag ataggtcatc ttttgctatt
    10021 taggtattgc tatttgtatc tccacagtat ccccttgatc ttttaagttt atcaatccat
    10081 catattgcgc aattgttgtt tggatatttt ttaaacccaa accatgattt tctttatctt
    10141 tcttagttgt gaaggactca tctatacttt cattgcttag cgtatatgtg gtaggcttag
    10201 catttaatat ttttataata agatatactt cgttaacata catctttaaa tcaattgcta
    10261 ggtttgttga gtttgaggca gtacatgctt caatggcatt atcaagtgaa ttaccaagaa
    10321 tgattgataa gtcaacatca tctattgaaa gagtattagg gacatctata tcaatactaa
    10381 agtctatttt ttctctgaat accctctctc ttttgacatt aattaatgca gcaatgattg
    10441 ggtgcctgag aataacaggg acggttcttt tgattactca atgattaaag tagtataatt
    10501 aggaaaaaag gtaaaggagc aatcgatatg ccacgaactg ccagagagaa aaataaaagt
    10561 ggtatatatc atgtgatgat tagaggagca aatagacaag agatctttca tgatgagcag
    10621 gactgtctaa gattccttga aatattagaa atatataaag tgaagacaga aattaagata
    10681 tatgattgct gcttgatgaa taatcaggcg aataataggg acggttcttt tgattaagca
    10741 atgataaagt agtataatta ggaaaaaagg taaaggagca atcaatatgc cacgaactgc
    10801 cagagagaaa agcaaaagcg gtatatatca tgtgatgatt agaggagcaa atagacagga
    10861 gatatttcat gatgagcagg actgtctaag atttcttgaa atattagaca gatataaagt
    10921 gaagacagaa attaagatat atggttggtg cttgatgaat aatcacatgc atttactcat
    10981 tcaagaaggt aaagaggaac ttgcgacaac tatgaagaga ataggtgtaa gctttgtagg
    11041 gtattaccat cagaaatatg atacaacagg gcatttgttt caagacaggt ttagaagtga
    11101 gaatgtggaa agtgatgaat atctgataac agtaatccgg tatatacatc aaaatccagt
    11161 aaaagctgga cttgtaagta agcctgtaga ttggaagtgg agtagttgtt caggatacta
    11221 tggaaagaaa gaatatctcc aaggactatt agatagtgag agaatactag gactattttc
    11281 aaatgataga gagagtgcaa taaaagaatt taggaaattt aatgaacaag aaaataaaga
    11341 taattgtctg gatgatgtta tcattacaag tcttagagat gaagaagcaa ggttagaaat
    11401 tgagaagata ctatcaggaa ttaatatagc gcaaataaag agtttgccaa aagatcaaag
    11461 agataagata attagagagg ctaaatgtat agagggtgta aagcagcgtc aattggcgag
    11521 gcttttaggg gtttcacaga caatgatatc aattgcgtaa tcaaaagaac cgtcccgaat
    11581 attcccgaat attccatcaa ttgcgtaatc aaaagaaccg tcccgaatat tccaccgtcc
    11641 cgaatattcc atgaactgga ggaattgtat gtataaaaga ataattttaa taatagcggc
    11701 attatttatc tttgctgctt gtggtgaaaa acttcaatat tctgtaccaa gcttagaaca
    11761 ggtgaatgaa tttatatctg acaattcagt taatgcatta gcgattaaag aagcagagga
    11821 ttttactatt gtgttatatg aaaacgagaa tggatttgga cactatgtat tgcatagaga
    11881 tcagaataat aaattatatg atggaaaagt catagcaatg agacataaag attatcaaca
    11941 aaacacactt tcattaggag gagtagcatc gggtaaaaat ccattcgtta cagtaattat
    12001 caatgacgat aacgttttag ataaagcaac tgaattggaa attttattta ctgatggggt
    12061 aaaggtaaaa gaacctatag ataataaggg gataattata atacatacaa ataatgaaag
    12121 tgacaagata ataaactatc taaaagtaac gatttatgat tccgatatga acattttata
    12181 tgaaaaataa atagtcatta taaataaaaa gctactggag aacgctataa aaaagatgct
    12241 gatgaattct atcagcatct ttttacactg atgtctcaga accattcccc cttgtctcgt
    12301 ctgttttttt gctcttttaa aaaaatttag ttgaaaaata aatgagataa gagtataata
    12361 aaatcaaaca tatgaacaca tgagcatatg tacaaaaaag ggagctgatt tgatggaaaa
    12421 agaaagaata acaatggata cttgcaactg caccatcatt catgaggata ttgtcaatag
    12481 agtaaaagaa tctatgcctc aggaagaaaa actctatgat ctcgctgaac tatttaaggt
    12541 atttggagat accactagaa ttaagattat ttatgcttta tttgagtcag aaatgtgtgt
    12601 gtgtgatatt gctgcacttc ttggcatgaa ccaatctgcc atatcacatc aactaagggt
    12661 gttgaagcaa gcgggattag ccaagtatag aagagaaggg aaagtagtct actactcctt
    12721 ggacgatgag cacgttaaaa atatttttga tcaaggatat actcatattg ctcataaata
    12781 aagggggaaa tgacatgagt tatgtaagcc atgtaatcaa aaaagaattg attctagaag
    12841 gtatggactg cgctggttgt acttctaaaa tagaagtagc catagctaaa ttagtaggtg
    12901 ttaaagaggt gtctttaaat tttgttacga agacgttgac aattgaaata gatgatgaga
    12961 gtaaaatgga gtctgttgtc tcagctgcaa aggatatcgt caatcaattt gaaccccatg
    13021 tcatcgtaaa agaaaagatg attgataaag tatcgaagaa agctttagtg ctaaagggat
    13081 tatcctgtgt aagctgcgct acaaaaattg aggataaagt aaaagaatta aagggcgtcc
    13141 atagtgtcta tatggatttt acatcggaga aattagtaat tgaggcaaag acacatgatt
    13201 ggcacagaat taccaaggaa gtaacggcta ttgtaaaaca tatagagtct gatgttgaag
    13261 tcattgatga aagtagaaag aaagatgaac agggtcatag tcacggcggc ggagacaata
    13321 agatggagct tatacgattg ggcattgggg ctatattata tgccatagca cttgcttttc
    13381 aaatgtcaga ttccattgaa tttgtattgt acttcataag ctatctactt ataggtggag
    13441 aagtattact gaaggcaggt agaaatatac gaagaggtca aattttcgat gaaaacttcc
    13501 taatgagtat tgcaacaata ggagcctttg ctatcggaga attccctgaa ggcgtagcgg
    13561 taatgctctt ctaccaaata ggtgagttct tccaggggtt agcggtgaat cgttctagaa
    13621 aatccatcgg agcgctgatg gatattcgac ctgattatgc taatcttaag gttggaaatg
    13681 atgtaaagaa ggtttctcca gaagaagtaa ctgtaggtga ccacattcta gtgaaaccag
    13741 gagaaaaagt acctcttgat ggtgttgtga tagaaggaca atccatggta gatacttcgg
    13801 ctttaacagg tgaatctgtg ccaagggaag tggaagtaga tagcaatgta ttaggcggat
    13861 ttattaataa aaacggtgta ttaacaatta aagtgagtaa agaatttggg gaatccacgg
    13921 tatctaagat tttagagtta gtagagaatg caagcagtaa aaaggcccca acagaaaact
    13981 ttatcactaa atttgcaaga tattatacac cggtagttgt atttgtagcc ctagccttag
    14041 caatcatacc accccttgtg attgacggtg ctactttttc agaatggatt tatagagcct
    14101 tggtatttct tgtaatctcc tgcccttgtg cattggtaat ctctatacca ctagggttct
    14161 ttgggggtat tggaggtgca tcgaaaaacg gaattctcat aaagggtgga aactatctgg
    14221 aagccctaaa cagtgttgat atagtagtct ttgataaaac aggtacattg acaaagggcg
    14281 tattcaaggt aatggagata aatgtagagc aaaatatctc aaaggaagaa ctgctagaat
    14341 atgcggctta tgccgaaagt tattctaacc atcctatctc cacatctatc ttaaaggcct
    14401 atggaaaaga agtaaataaa gaagaaattg aaagttataa tgaaatatca gggcatggta
    14461 ttaaaataaa ggtcaaagat aaggaaattt tagcaggtaa cattaaattg atggatagcg
    14521 aaaaaattgc atatgaacca gtagaagcta taggaaccat agtatatgta gcaattaacg
    14581 gaaaacttgc tggttctatc attatttcag atgagataaa ggaagattct cagcgtgcaa
    14641 ttaaagaatt aaaggctatt ggtgttaaaa agattgtgat gcttacagga gacaacaagc
    14701 aagtaggaat aaaagtggcg aagcaattag gcatagatga ggtacacaca gaactgctac
    14761 ctgatgaaaa agttgagaag ctggagcaat tagatagaca gaaatcacca aaagggaaat
    14821 tggtctttgt tggagatggg atcaatgatg ccccggtttt agctagagca gatattggtg
    14881 tagccatggg tggattggga tctgatgcag ctattgaagc ggctgatgtt gtcctaatga
    14941 ctgatgaacc aatgaaacta gtcagcgcca taaagatagc aaaaagaaca aagcgtattg
    15001 tatggcaaaa cattatcttt gcttttggag taaaagggat tgttctactg ctaggagctg
    15061 gtggtcttgc aaccatgtgg gaagccgtat ttgccgatgt aggtgtagca ctaatcgcag
    15121 tatttaacgc catgagggtt ttaaatgtaa aaaatctata aaattttgtt gatacagaag
    15181 gagggtgcct gcatatcatt ttgcaagcac cctcaccgta tctattgcgt gtatatagat
    15241 tctgattaac agaggaaagg aggcaaaaat gagtatagga tatgcgtgtt taacggttgg
    15301 ggttgaaaat accgatcaga aaagctgtat gcttaaaaat gcaagtgaaa gcagattgtc
    15361 agaaatagtc gcctacaatt tatctgctct tgaaaatatc attgattata atatcaaaaa
    15421 ccaaataaaa ctctttagga ttagctcgga tttaatcccc tttggttcaa gtccgatgaa
    15481 cacactccat tggtgggatg tgtatagatc tgatttttca aaaataggtg aaaaaattaa
    15541 aaagagcggt atgagggttt ccatgcaccc ggggcaatat accgtattaa actcaccaag
    15601 agaagaagtt gtggagaggg caattcaaga cttaaattat catgcaagag tactggactg
    15661 tctaggagta ggtcctgagc ataagatagt attacatatc ggaggcatct atgatgataa
    15721 aaaggaagcg atggatagat ttataaggaa ttaccaaagc ctagaggaag cagttaaaaa
    15781 gaggcttgtg atagaaaacg atgataaatc ctataccata agtgatgtat tggaaatcgg
    15841 agcaatactt aatataccgg ttatttttga taacctccat aatgaaatta accccagtga
    15901 ccaggaaaga gatgaacttt attggatcgg ggcgtgtaga aaaacatggg aggaaaagga
    15961 tgggaatcaa aaaatccatt actcacagca gaatccagaa aaaagagctg gatctcattc
    16021 tgaaagtatt gggattaatg agtttatggt cttttatcaa aagatcaaaa gagatgatct
    16081 tgatatgatg ctagaagtaa aagacaaaaa cctctcagca gtaaaatgta ttaatagcac
    16141 gtcaacacag aaaaaaatta aggcacttga gcttgagtgg agtaagtata aatacacaat
    16201 tttagaaacc tcaccagtaa actatttgga gattcgtaaa atactcaagg ataaggatgg
    16261 gtaccctgca atttcttttt ataccttagt tgaagaagct ttacaaaaag agcggaccat
    16321 tgaaaatgca gtcaatgccg cacagcatgt ttggggatat ttcaaagatg tagcaagtga
    16381 aaaagaaaaa caagcatttc taaagaacat ggataaattt ataaaaaaag aaacttcaat
    16441 tagatccatt aagcgaaatc tatggaagtt agctgttaaa tacaaggaag aatatctttt
    16501 aagttcatat tattttgtgt tataaaaaag gtgctgatga atttgatcag cgcctttttt
    16561 atatagcagg aaagttttcc tttcctacta tataaaaaac aggggttgaa aggggaagta
    16621 ttccccttcc gtagtcagaa gggtgctcag acgactttgt cgtcgtcgaa gtgaaactag
    16681 gtttccatag cgaaagcgtc gaagacgctc ttcttttaat ccaaaaaaaa ttcaaaaaac
    16741 ccttgacaga caagggtata aatattatga taatagtgca ctataaaact agtgcgctag
    16801 atgtgtaatg agaggtggaa ctaggatgga atttaacaat tcaaagccaa tctatttaca
    16861 aattatcgat tatattaaaa agcagttaat tcggggtgaa ttaaagggtg gagacaagat
    16921 ttcttcccag cgagaatttg ctcaacaaat gaaggtcaac cccaatacag ttcaaagggc
    16981 ttaccgagag atggaaagta tgcaactggt agaaaccatt cgagggcaag ggacctttat
    17041 ttgtaaccag gaagaaatgc tagcagtcat tcaagaagaa atggcaggag atctactaag
    17101 acactttata gaggaaatgt attcattggg ctatagcaaa gaagcaatgg ttcaactaat
    17161 agagaaatgg aaaacagaag taagggagga agaaaaatga ttgaatttaa gggtgtaacg
    17221 aagaaattcg gcagtacaat agccgtagat aatgtgacca tgacatttcc taaggggaag
    17281 attattggat tactagggcc taatggttcc gggaagtcaa ccactttaaa aatgatcgcc
    17341 tcattaaata agccagatca gggagaaatc actattgatg gcaagagtcc ttctaaagaa
    17401 acaagggaaa ccttagccta tctaccggaa attgactatc tttatccctg gatgaccatt
    17461 gaaggagcag gaaagttcat gaaaagcttc tatgatgatt ggaatgagga aaagtttcaa
    17521 tccctgatga agtttttaaa tctggaacct caaatgatta taaaaaaaat ctcaaaaggg
    17581 atgagggcaa aggccaagct cctattggtg ttctcacgaa atgccaagct ggttttactg
    17641 gatgaaccat tatcgggcat tgatatattc acccgagatc aaattatcga tacaattatt
    17701 caggattatt gcgaaggaga gcaaaccatt attctttcaa cccatgagat tcatgaagta
    17761 gaaagtctcc tagactatgt ggtttttatg caccaaggaa caatccttcg tcaaggagaa
    17821 gcggaagacc ttcggagcga agaaaataaa tccttggtag agttgatgaa ggaggtttat
    17881 cgaaatgaaa acatctagag taggcatgat ttatagctta tataaaaaag aattagtagc
    17941 agctaaaaac gagctcctaa tgattatgac tttcatttta ggagccaatg cgtttctatt
    18001 ttataaacac caaacaggat ggcccgtaga agccagcttt atctttagtt tattcttatt
    18061 gttatttgtt gtagccacta ctttctttag agccttctcc gtcgttagga atgagtggaa
    18121 ggaaaacacg gtgtacttag tgatgtcttt acccattacg ggggtagatg tttttttatc
    18181 caagttatta gccctattaa cacaattgat aggacttagt atcattgccc taataggcgc
    18241 ttccctcttt attcccatta tcccggaggt atcctatgtc ctggaacaaa tacaaatgga
    18301 attcacaagc gtcaggttaa tttggaatgc attgaaaata ggtctacttg gcatcttagg
    18361 catgaaccag gccattatat tcgcattctt cagtgctgtt gttggtaagc tctttaagaa
    18421 attctcaggg ctcatcacct taattacatt tatcggcata tcaatgatta attcaaaatt
    18481 cattgattgg ataggcaact tcttcattga ccagggtatg ggggagcgaa tagagagtca
    18541 gctgatggga ctggacgtca caatgatgac agccatggaa acaatgttaa acgtctatac
    18601 attactattt acaatcataa ctgtggtcac ttcagcaggg gtattctttg ccacagcagc
    18661 cctctatgat cgtaaggtag aactgtag
//
