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Overview
4.1
4.2
4.3
4.4
4.5
4.6

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP044117.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | betalactone | 124,896 | 147,613 | fengycin | NRP | 13%
Region 4.2 | thioamitides | 192,930 | 215,589 | asukamycin | Polyketide:Type II | 4%
Region 4.3 | phosphonate,terpene | 1,361,755 | 1,408,782 | phosphinothricintripeptide | NRP | 6%
Region 4.4 | terpene | 1,560,079 | 1,580,900 |
Region 4.5 | T1PKS | 3,242,695 | 3,290,242 |
Region 4.6 | NRPS | 4,136,187 | 4,180,122 | heterobactin A / heterobactin S2 | NRP | 36%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | betalactone | 124,896 | 147,613 | fengycin | NRP | 13%
Region 4.2 | thioamitides | 192,930 | 215,589 | asukamycin | Polyketide:Type II | 4%
Region 4.3 | phosphonate,terpene | 1,361,755 | 1,408,782 | phosphinothricintripeptide | NRP | 6%
Region 4.4 | terpene | 1,560,079 | 1,580,900 |
Region 4.5 | T1PKS | 3,242,695 | 3,290,242 |
Region 4.6 | NRPS | 4,136,187 | 4,180,122 | heterobactin A / heterobactin S2 | NRP | 36%

No secondary metabolite regions were found in these records:
  NZ_CP044114.1
  NZ_CP044115.1
  NZ_CP044116.1
  NZ_CP044118.1

Compact view
NZ_CP044117.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 124,896 - 147,613 nt. (total: 22,718 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.22 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000932.1 |  | 0.20 | Other | tropodithietic acid | Phaeobacter inhibens DSM 17395
BGC0001362.1 |  | 0.20 | Other | tropodithietic acid | Phaeobacter inhibens DSM 17395
BGC0000890.1 |  | 0.19 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000258.1 |  | 0.18 | Polyketide | prodigiosin | Serratia sp.
BGC0000410.1 |  | 0.16 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000544.1 |  | 0.16 | RiPP | planosporicin | Planomonospora alba
BGC0000556.1 |  | 0.16 | RiPP | streptin | Streptococcus pyogenes
BGC0000506.1 |  | 0.16 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0001140.1 |  | 0.16 | Terpene | platensimycin, platencin | Streptomyces platensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000234.1 |  | 0.55 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000932.1 |  | 0.52 | Other | tropodithietic acid | Phaeobacter inhibens DSM 17395
BGC0001362.1 |  | 0.52 | Other | tropodithietic acid | Phaeobacter inhibens DSM 17395
BGC0000890.1 |  | 0.51 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000258.1 |  | 0.50 | Polyketide | prodigiosin | Serratia sp.
BGC0000410.1 |  | 0.47 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0000544.1 |  | 0.47 | RiPP | planosporicin | Planomonospora alba
BGC0000556.1 |  | 0.47 | RiPP | streptin | Streptococcus pyogenes
BGC0000506.1 |  | 0.47 | RiPP | entianin | Bacillus subtilis subsp. spizizenii
BGC0001140.1 |  | 0.46 | Terpene | platensimycin, platencin | Streptomyces platensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP044117.1 - Region 2 - thioamitides
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 192,930 - 215,589 nt. (total: 22,660 nt) Show pHMM detection rules used
thioamitides: ((YcaO or TIGR03882) and TfuA)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thioamitides | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001849.1 |  | 0.23 | RiPP | thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D | Streptomyces varsoviensis
BGC0001696.1 |  | 0.14 | RiPP | neothioviridamide | Streptomyces sp.
BGC0001802.1 |  | 0.14 | RiPP | thioholgamide A, thioholgamide B | Streptomyces malaysiense
BGC0000703.1 |  | 0.14 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001909.1 |  | 0.11 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001157.1 |  | 0.09 | RiPP | bottromycin A2 | Streptomyces scabiei 87.22
BGC0001474.1 |  | 0.08 | RiPP | thiopeptin | Streptomyces tateyamensis
BGC0001473.1 |  | 0.07 | RiPP | Sch 18640 | Micromonospora arborensis
BGC0002023.1 |  | 0.06 | RiPP | saalfelduracin | Amycolatopsis saalfeldensis
BGC0001471.1 |  | 0.06 | RiPP | saalfelduracin | Amycolatopsis saalfeldensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001849.1 |  | 0.56 | RiPP | thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D | Streptomyces varsoviensis
BGC0001696.1 |  | 0.43 | RiPP | neothioviridamide | Streptomyces sp.
BGC0001802.1 |  | 0.43 | RiPP | thioholgamide A, thioholgamide B | Streptomyces malaysiense
BGC0000703.1 |  | 0.42 | Saccharide | kanamycin | Streptomyces kanamyceticus
BGC0001909.1 |  | 0.38 | Polyketide | strobilurin | Strobilurus tenacellus
BGC0001157.1 |  | 0.32 | RiPP | bottromycin A2 | Streptomyces scabiei 87.22
BGC0001474.1 |  | 0.30 | RiPP | thiopeptin | Streptomyces tateyamensis
BGC0001473.1 |  | 0.28 | RiPP | Sch 18640 | Micromonospora arborensis
BGC0002023.1 |  | 0.26 | RiPP | saalfelduracin | Amycolatopsis saalfeldensis
BGC0001471.1 |  | 0.25 | RiPP | saalfelduracin | Amycolatopsis saalfeldensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP044117.1 - Region 3 - phosphonate,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,361,755 - 1,408,782 nt. (total: 47,028 nt) Show pHMM detection rules used
phosphonate: phosphonates
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000648.1 |  |  | 0.67 | Terpene | carotenoid | Myxococcus xanthus
BGC0000647.1 |  |  | 0.65 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000646.1 |  |  | 0.49 | Terpene | β-carotein | uncultured bacterium
BGC0000656.1 |  |  | 0.49 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000630.1 |  |  | 0.49 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000635.1 |  |  | 0.49 | Terpene | carotenoid | Paracoccus sp. N81106
BGC0000640.1 |  |  | 0.46 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001227.1 |  |  | 0.46 | Terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000639.1 |  |  | 0.42 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000641.1 |  |  | 0.42 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.67 | Terpene | carotenoid | Myxococcus xanthus
BGC0000647.1 |  | 0.66 | Terpene | carotenoid | Rhodobacter sphaeroides
BGC0000635.1 |  | 0.61 | Terpene | carotenoid | Paracoccus sp. N81106
BGC0000646.1 |  | 0.58 | Terpene | β-carotein | uncultured bacterium
BGC0000656.1 |  | 0.58 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000630.1 |  | 0.58 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001859.1 |  | 0.56 | Other (Phosphonate) | fosfomycin | Pseudomonas syringae
BGC0000640.1 |  | 0.56 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001227.1 |  | 0.56 | Terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000639.1 |  | 0.54 | Terpene | carotenoid | Enterobacteriaceae bacterium DC260

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP044117.1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,560,079 - 1,580,900 nt. (total: 20,822 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001488.1 |  | 0.19 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000779.1 |  | 0.18 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0001973.1 |  | 0.18 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.18 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000780.1 |  | 0.17 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0001891.1 |  | 0.17 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000551.1 |  | 0.17 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000554.1 |  | 0.17 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001120.1 |  | 0.17 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000519.1 |  | 0.16 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001488.1 |  | 0.52 | Other | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000779.1 |  | 0.50 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0001973.1 |  | 0.50 | Other | fervenulin | Streptomyces hiroshimensis
BGC0001972.1 |  | 0.50 | Other | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0000780.1 |  | 0.49 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0001891.1 |  | 0.48 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000551.1 |  | 0.48 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000554.1 |  | 0.48 | RiPP | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001120.1 |  | 0.48 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0000519.1 |  | 0.46 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP044117.1 - Region 5 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,242,695 - 3,290,242 nt. (total: 47,548 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001340.1 |  | 0.30 | Polyketide | byssochlamic acid | Byssochlamys fulva
BGC0001124.1 |  | 0.29 | Polyketide | pyranonigrin E | Aspergillus niger ATCC 1015
BGC0000046.1 |  | 0.28 | Polyketide | depudecin | Alternaria brassicicola
BGC0001067.1 |  | 0.27 | Polyketide, Terpene | fumagillin, β-trans-bergamotene, fumagillol | Aspergillus fumigatus Af293
BGC0001913.1 |  | 0.26 | Polyketide | phomoidride | fungal sp. ATCC 74256
BGC0001504.1 |  | 0.26 | Polyketide | amycomicin | Amycolatopsis sp. AA4
BGC0001205.1 |  | 0.24 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum
BGC0001141.1 |  | 0.23 | Polyketide | 4-epi-15-epi-brefeldin A | Penicillium brefeldianum
BGC0001283.1 |  | 0.23 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0001264.1 |  | 0.22 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001340.1 |  | 0.63 | Polyketide | byssochlamic acid | Byssochlamys fulva
BGC0001124.1 |  | 0.62 | Polyketide | pyranonigrin E | Aspergillus niger ATCC 1015
BGC0000046.1 |  | 0.62 | Polyketide | depudecin | Alternaria brassicicola
BGC0001067.1 |  | 0.60 | Polyketide, Terpene | fumagillin, β-trans-bergamotene, fumagillol | Aspergillus fumigatus Af293
BGC0001913.1 |  | 0.60 | Polyketide | phomoidride | fungal sp. ATCC 74256
BGC0001504.1 |  | 0.59 | Polyketide | amycomicin | Amycolatopsis sp. AA4
BGC0001205.1 |  | 0.58 | Polyketide | communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H | Penicillium expansum
BGC0001141.1 |  | 0.57 | Polyketide | 4-epi-15-epi-brefeldin A | Penicillium brefeldianum
BGC0001283.1 |  | 0.56 | Polyketide | arsono-polyketide | Streptomyces lividans 1326
BGC0001264.1 |  | 0.55 | Polyketide | betaenone A, betaenone B, betaenone C | Phoma betae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 3242694 - 3290242:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (redmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg4_2948: mal
  PKS_AT (566..856): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 75.0%
    CE-Malonyl-CoA: 62.5%
    Methylmalonyl-CoA: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 89.3
    Methylmalonyl-CoA: 84.3
    Methoxymalonyl-CoA: 78.8
    Isobutyryl-CoA: 62.6
    Ethylmalonyl-CoA: 55.1
    Propionyl-CoA: 36.7
    Benzoyl-CoA: 22.8
    trans-1,2-CPDA: 22.6
    2-Methylbutyryl-CoA: 20.9
    inactive: 16.9
    3-Methylbutyryl-CoA: 13.0
    fatty_acid: 9.2
    Acetyl-CoA: 8.4
    CHC-CoA: 6.9

NZ_CP044117.1 - Region 6 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,136,187 - 4,180,122 nt. (total: 43,936 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000401.1 |  | 0.28 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001185.1 |  | 0.27 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000632.1 |  | 0.25 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001833.1 |  | 0.25 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.24 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001844.1 |  | 0.24 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.23 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.23 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001149.1 |  | 0.23 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000401.1 |  | 0.62 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001185.1 |  | 0.61 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000632.1 |  | 0.59 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica
BGC0001399.1 |  | 0.58 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001833.1 |  | 0.58 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.1 |  | 0.57 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001844.1 |  | 0.57 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001128.1 |  | 0.57 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.1 |  | 0.57 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001149.1 |  | 0.56 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 4136186 - 4180122:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg4_3693: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (99..352): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      tG-MiGigpK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      40% (weak)
ctg4_3704: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (35..444): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PMPglGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      80% (moderate)
ctg4_3707: ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (464..853): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)