Select genomic region:
Overview
2.1
2.2
2.3
2.4
2.5
2.6
2.7
2.8
2.9
2.10
2.11
2.12
2.13
2.14
2.15

### Identified secondary metabolite regions using strictness 'relaxed'

c00002_NZ_CABE.. (original name was: NZ_CABEIC010000002.1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | T1PKS,NRPS-like | 312,149 | 385,187 | salinichelins | NRP | 15%
Region 2.2 | NRPS,siderophore | 702,844 | 744,539 | amychelin | NRP | 18%
Region 2.3 | NRPS | 1,233,173 | 1,287,044 |
Region 2.4 | ectoine | 2,367,241 | 2,377,675 | ectoine | Other | 75%
Region 2.5 | terpene | 2,701,496 | 2,720,322 | SF2575 | Polyketide:Type II + Saccharide:Hybrid/tailoring | 6%
Region 2.6 | arylpolyene | 2,929,533 | 2,970,783 | primycin | Polyketide | 5%
Region 2.7 | NRPS,betalactone | 3,193,825 | 3,267,998 | echoside A / echoside B / echoside C / echoside D / echoside E | NRP | 11%
Region 2.8 | NRPS | 4,274,498 | 4,401,371 | ishigamide | NRP + Polyketide | 11%
Region 2.9 | redox-cofactor | 4,403,619 | 4,426,715 |
Region 2.10 | NRPS | 4,503,601 | 4,560,470 |
Region 2.11 | NRPS-like | 4,560,853 | 4,602,648 | rifamorpholine A / rifamorpholine B / rifamorpholine C / rifamorpholine D / rifamorpholine E | Polyketide | 3%
Region 2.12 | NRPS | 4,826,957 | 4,871,210 |
Region 2.13 | NAPAA | 5,145,311 | 5,179,177 |
Region 2.14 | terpene | 5,291,625 | 5,312,563 | oxalomycin B | NRP + Polyketide | 6%
Region 2.15 | RiPP-like | 5,355,597 | 5,366,406 | pimaricin | Polyketide | 11%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | T1PKS,NRPS-like | 312,149 | 385,187 | salinichelins | NRP | 15%
Region 2.2 | NRPS,siderophore | 702,844 | 744,539 | amychelin | NRP | 18%
Region 2.3 | NRPS | 1,233,173 | 1,287,044 |
Region 2.4 | ectoine | 2,367,241 | 2,377,675 | ectoine | Other | 75%
Region 2.5 | terpene | 2,701,496 | 2,720,322 | SF2575 | Polyketide:Type II + Saccharide:Hybrid/tailoring | 6%
Region 2.6 | arylpolyene | 2,929,533 | 2,970,783 | primycin | Polyketide | 5%
Region 2.7 | NRPS,betalactone | 3,193,825 | 3,267,998 | echoside A / echoside B / echoside C / echoside D / echoside E | NRP | 11%
Region 2.8 | NRPS | 4,274,498 | 4,401,371 | ishigamide | NRP + Polyketide | 11%
Region 2.9 | redox-cofactor | 4,403,619 | 4,426,715 |
Region 2.10 | NRPS | 4,503,601 | 4,560,470 |
Region 2.11 | NRPS-like | 4,560,853 | 4,602,648 | rifamorpholine A / rifamorpholine B / rifamorpholine C / rifamorpholine D / rifamorpholine E | Polyketide | 3%
Region 2.12 | NRPS | 4,826,957 | 4,871,210 |
Region 2.13 | NAPAA | 5,145,311 | 5,179,177 |
Region 2.14 | terpene | 5,291,625 | 5,312,563 | oxalomycin B | NRP + Polyketide | 6%
Region 2.15 | RiPP-like | 5,355,597 | 5,366,406 | pimaricin | Polyketide | 11%

No secondary metabolite regions were found in these records:
  c00001_NZ_CABE.. (original name was: NZ_CABEIC010000001.1)

Compact view
c00002_NZ_CABE.. - Region 1 - NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 312,149 - 385,187 nt. (total: 73,039 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002009.1 |  |  | 0.35 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0001458.1 |  |  | 0.32 | Other (Aminocoumarin) | salinipostin G | Salinispora tropica CNB-440
BGC0001292.1 |  |  | 0.32 | Other | A33853 | Streptomyces sp. NRRL 12068
BGC0000979.1 |  |  | 0.31 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  |  | 0.31 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0000393.1 |  |  | 0.31 | NRP, Polyketide | myxoprincomide-c506 | Myxococcus xanthus DK 1622
BGC0001794.1 |  |  | 0.30 | Polyketide | swainsonine | Alternaria oxytropis
BGC0001160.1 |  |  | 0.30 | Polyketide | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001793.1 |  |  | 0.30 | Polyketide | swainsonine | Chaetothyriaceae sp.
BGC0000467.1 |  |  | 0.30 | NRP | yersiniabactin | Yersinia enterocolitica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001163.1 |  | 0.63 | Polyketide | 1-heptadecene | Moorea producens 3L
BGC0001161.1 |  | 0.63 | Polyketide | 1-heptadecene | Moorea bouillonii PNG
BGC0001162.1 |  | 0.63 | Polyketide | 1-heptadecene | Moorea producens JHB
BGC0001281.1 |  | 0.57 | Polyketide | ustilagic acid | Ustilago maydis 521
BGC0000935.1 |  | 0.57 | Other (Aminocoumarin), Polyketide | esmeraldin | Streptomyces antibioticus
BGC0000236.1 |  | 0.57 | Polyketide | kinamycin | Streptomyces murayamaensis
BGC0001831.1 |  | 0.57 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0000056.1 |  | 0.57 | Polyketide | esperamicin | Actinomadura verrucosospora
BGC0000220.1 |  | 0.56 | Polyketide | enterocin | Streptomyces maritimus
BGC0001762.1 |  | 0.56 | Alkaloid | rubrolone A, rubrolone B | Streptomyces sp. KIB-H033

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 312148 - 385187:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 312148 - 357449:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 346494 - 385187:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_311: pk
  CAL_domain (57..521): pk
  minowa: Acetyl-CoA
  Prediction, score:
    Acetyl-CoA: 33.3
    fatty_acid: 17.4
    NH2: 10.2
    AHBA: 9.8
    shikimic_acid: 0.0
ctg2_312: pk
  PKS_AT (722..1024): pk
  ATSignature: Malonyl-CoA, Methylmalonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 54.2%
    Methylmalonyl-CoA: 54.2%
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 145.2
    Methylmalonyl-CoA: 68.9
    Methoxymalonyl-CoA: 63.7
    Malonyl-CoA: 48.1
    Propionyl-CoA: 46.4
    Isobutyryl-CoA: 41.4
    trans-1,2-CPDA: 39.9
    Ethylmalonyl-CoA: 36.4
    Acetyl-CoA: 27.9
    2-Methylbutyryl-CoA: 22.1
    Benzoyl-CoA: 14.4
    inactive: 13.3
    CHC-CoA: 12.8
    3-Methylbutyryl-CoA: 0.0
ctg2_327: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (35..409): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ggdHSccgnK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      30% (weak)

c00002_NZ_CABE.. - Region 2 - NRPS,siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 702,844 - 744,539 nt. (total: 41,696 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001572.1 |  |  | 0.65 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001478.1 |  |  | 0.63 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.1 |  |  | 0.61 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001453.1 |  |  | 0.59 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000940.1 |  |  | 0.56 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0000942.1 |  |  | 0.51 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0000373.1 |  |  | 0.49 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000412.1 |  |  | 0.45 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0001531.1 |  |  | 0.44 | Other | bisucaberin B | Tenacibaculum mesophilum
BGC0001499.1 |  |  | 0.44 | Other | aerobactin | Pantoea ananatis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001572.1 |  | 0.67 | Other | desferrioxamine E | Pantoea agglomerans
BGC0001453.1 |  | 0.67 | Other | desferrioxamine | Streptomyces argillaceus
BGC0001478.1 |  | 0.64 | Other | desferrioxamine E | Streptomyces sp. ID38640
BGC0000373.1 |  | 0.63 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0000941.1 |  | 0.62 | Other | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000940.1 |  | 0.61 | Other | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0000412.1 |  | 0.59 | NRP | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000942.1 |  | 0.59 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001831.1 |  | 0.58 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001499.1 |  | 0.57 | Other | aerobactin | Pantoea ananatis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 702843 - 744539:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_648: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (43..450): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPsQGViCK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      80% (moderate)
ctg2_661: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (671..1059): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNigLIhK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      70% (weak)
ctg2_662: pk
  CAL_domain (172..469): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 31.3
    Acetyl-CoA: 9.2
    shikimic_acid: 0.0
    AHBA: 0.0
    NH2: -4.5

c00002_NZ_CABE.. - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,233,173 - 1,287,044 nt. (total: 53,872 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.1 |  | 0.30 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.28 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.28 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001185.1 |  | 0.28 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000417.1 |  | 0.28 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000401.1 |  | 0.27 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001844.1 |  | 0.27 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001585.1 |  | 0.27 | Alkaloid | melinacidin IV | Escovopsis weberi
BGC0001591.1 |  | 0.27 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.27 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.1 |  | 0.64 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.62 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.61 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001185.1 |  | 0.61 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000417.1 |  | 0.61 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000401.1 |  | 0.61 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001844.1 |  | 0.61 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001585.1 |  | 0.60 | Alkaloid | melinacidin IV | Escovopsis weberi
BGC0001591.1 |  | 0.60 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.60 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1233172 - 1287044:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - thr - leu - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_1148: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (47..289): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      hIqslGtGGK
    Nearest Stachelhaus code:
      tcl
    Stachelhaus code match:
      50% (weak)
ctg2_1153: X - thr - leu - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (488..864): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      wALVvdAgpK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      50% (weak)
  AMP-binding (1502..1881): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWSVGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2556..2955): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAmlAGeVaK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      60% (weak)
  AMP-binding (4210..4573): X
  NRPSPredictor2: orn, lys, arg
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      orn, lys, arg
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAhTyGiVtK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      60% (weak)

c00002_NZ_CABE.. - Region 4 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,367,241 - 2,377,675 nt. (total: 10,435 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000853.1 |  | 0.43 | Other | ectoine | Streptomyces anulatus
BGC0000854.1 |  | 0.41 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000852.1 |  | 0.38 | Other | ectoine | Sporosarcina pasteurii
BGC0000859.1 |  | 0.33 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000856.1 |  | 0.33 | Other | ectoine | Methylophaga thalassica
BGC0000855.1 |  | 0.33 | Other | ectoine | Methylomicrobium kenyense
BGC0000858.1 |  | 0.33 | Other | ectoine | Methylobacter marinus
BGC0000857.1 |  | 0.30 | Other | ectoine | Methylophaga alcalica
BGC0000860.1 |  | 0.30 | Other | ectoine | Methylarcula marina
BGC0000895.1 |  | 0.14 | Other | citrulline | Lactobacillus plantarum subsp. plantarum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000853.1 |  | 0.74 | Other | ectoine | Streptomyces anulatus
BGC0000854.1 |  | 0.73 | Other | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000852.1 |  | 0.71 | Other | ectoine | Sporosarcina pasteurii
BGC0000859.1 |  | 0.66 | Other | ectoine | Methylomicrobium alcaliphilum
BGC0000856.1 |  | 0.66 | Other | ectoine | Methylophaga thalassica
BGC0000855.1 |  | 0.66 | Other | ectoine | Methylomicrobium kenyense
BGC0000858.1 |  | 0.66 | Other | ectoine | Methylobacter marinus
BGC0000857.1 |  | 0.64 | Other | ectoine | Methylophaga alcalica
BGC0000860.1 |  | 0.63 | Other | ectoine | Methylarcula marina
BGC0000895.1 |  | 0.44 | Other | citrulline | Lactobacillus plantarum subsp. plantarum

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_CABE.. - Region 5 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,701,496 - 2,720,322 nt. (total: 18,827 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000204.1 |  | 0.21 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001197.1 |  | 0.20 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0002008.1 |  | 0.17 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000234.1 |  | 0.17 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000836.1 |  | 0.17 | Other | APE Ec | Escherichia coli CFT073
BGC0000228.1 |  | 0.17 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001140.1 |  | 0.16 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001768.1 |  | 0.16 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4
BGC0000460.1 |  | 0.16 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0001927.1 |  | 0.16 | Other | A-94964 | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000204.1 |  | 0.53 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001197.1 |  | 0.53 | Polyketide | frankiamicin | Frankia sp. EAN1pec
BGC0002008.1 |  | 0.48 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000234.1 |  | 0.48 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000836.1 |  | 0.48 | Other | APE Ec | Escherichia coli CFT073
BGC0000228.1 |  | 0.47 | Polyketide | granaticin | Streptomyces violaceoruber
BGC0001140.1 |  | 0.47 | Terpene | platensimycin, platencin | Streptomyces platensis
BGC0001768.1 |  | 0.47 | NRP | sansalvamide | [Nectria] haematococca mpVI 77-13-4
BGC0000460.1 |  | 0.47 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0001927.1 |  | 0.47 | Other | A-94964 | Streptomyces sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_CABE.. - Region 6 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,929,533 - 2,970,783 nt. (total: 41,251 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001441.1 |  | 0.26 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0002007.1 |  | 0.24 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0001343.1 |  | 0.22 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000495.1 |  | 0.19 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000874.1 |  | 0.18 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0000528.1 |  | 0.17 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000496.1 |  | 0.17 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.1 |  | 0.17 | Terpene | carotenoid | Brevibacterium linens
BGC0000713.1 |  | 0.17 | Saccharide | ribostamycin | Streptomyces ribosidificus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001441.1 |  | 0.59 | Other | belactosin A, belactosin C | Streptomyces sp.
BGC0002007.1 |  | 0.57 | Terpene | atolypene A, atolypene B | Amycolatopsis tolypomycina
BGC0001343.1 |  | 0.54 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001897.1 |  | 0.53 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000495.1 |  | 0.52 | RiPP | actagardine | Actinoplanes garbadinensis
BGC0000874.1 |  | 0.50 | Other | blasticidin S | Streptomyces griseochromogenes
BGC0000528.1 |  | 0.48 | RiPP | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000496.1 |  | 0.48 | RiPP | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.1 |  | 0.48 | Terpene | carotenoid | Brevibacterium linens
BGC0000713.1 |  | 0.48 | Saccharide | ribostamycin | Streptomyces ribosidificus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_CABE.. - Region 7 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,193,825 - 3,267,998 nt. (total: 74,174 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000389.1 |  |  | 0.84 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001135.1 |  |  | 0.64 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000426.1 |  |  | 0.64 | NRP | sevadicin | Paenibacillus larvae
BGC0001758.1 |  |  | 0.63 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000901.1 |  |  | 0.61 | Other | ferrichrome | Aspergillus niger
BGC0001844.1 |  |  | 0.61 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001220.1 |  |  | 0.61 | NRP | aculeacin A | Aspergillus japonicus
BGC0001833.1 |  |  | 0.60 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001131.1 |  |  | 0.60 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001128.1 |  |  | 0.59 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000389.1 |  | 0.73 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001135.1 |  | 0.65 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000426.1 |  | 0.65 | NRP | sevadicin | Paenibacillus larvae
BGC0001758.1 |  | 0.65 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000901.1 |  | 0.64 | Other | ferrichrome | Aspergillus niger
BGC0001844.1 |  | 0.64 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001220.1 |  | 0.64 | NRP | aculeacin A | Aspergillus japonicus
BGC0001833.1 |  | 0.64 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000457.1 |  | 0.64 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001131.1 |  | 0.63 | NRP | ambactin | Xenorhabdus miraniensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 3193824 - 3267998:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ser - X) + (X - X - D-ser - ser - ser - X - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_2886: X - X - ser - ser - ser - X - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (123..545): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGnhsmVYK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      60% (weak)
  AMP-binding (1255..1681): X
  NRPSPredictor2: gly, ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFTcAliwK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2382..2784): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVpHySLVeK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      70% (weak)
  AMP-binding (4035..4455): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (5134..5554): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (6218..6615): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAlFLGgiiK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (7290..7690): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVpHnSLVeK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      70% (weak)
ctg2_2887: ser - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (464..883): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLIDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1567..1969): X
  NRPSPredictor2: gly, ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWiMaLIwK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      70% (weak)

c00002_NZ_CABE.. - Region 8 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,274,498 - 4,401,371 nt. (total: 126,874 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.1 |  | 0.34 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.34 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001758.1 |  | 0.34 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.34 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001615.1 |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001135.1 |  | 0.33 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000392.1 |  | 0.33 | NRP | mirubactin | Actinosynnema mirum DSM 43827
BGC0001479.1 |  | 0.33 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000401.1 |  | 0.33 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001790.1 |  | 0.32 | NRP | sulfazecin | Pseudomonas acidophila

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.1 |  | 0.67 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000417.1 |  | 0.67 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0001758.1 |  | 0.67 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001844.1 |  | 0.67 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001135.1 |  | 0.66 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000392.1 |  | 0.66 | NRP | mirubactin | Actinosynnema mirum DSM 43827
BGC0001479.1 |  | 0.66 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000401.1 |  | 0.66 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001790.1 |  | 0.66 | NRP | sulfazecin | Pseudomonas acidophila

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 4274497 - 4401371:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (thr - ser) + (thr - gln - D-leu - thr - glu - D-ser - glu - ser - X - D-ser - X) + (ser - D-leu - X - X) + (ser - X - X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_3834: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (10..401): X
  NRPSPredictor2: hydrophobic-aromatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      tgLtfGcgMK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      40% (weak)
ctg2_3850: ser - X - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (493..878): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1564..1958): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALfVGaVVK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (2656..3034): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALFgGsivK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      60% (weak)
  AMP-binding (3739..4168): X
  NRPSPredictor2: val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAlFaGViiK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      60% (weak)
ctg2_3867: ser - leu - X - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (5..429): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1095..1488): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALlVGfVwK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      70% (weak)
  AMP-binding (2690..3090): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DpGthGqIyK
    Nearest Stachelhaus code:
      orn
    Stachelhaus code match:
      50% (weak)
  AMP-binding (3758..4157): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALfsGgiMK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      60% (weak)
ctg2_3868: thr - gln - leu - thr - glu - ser - glu - ser - X - ser - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (80..488): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWSVGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1151..1555): gln
  NRPSPredictor2: gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWQFGqvDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (2215..2610): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAlFWGVivK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      70% (weak)
  AMP-binding (3770..4173): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWSVGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4838..5242): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWkFGqVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (5912..6315): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVpHFSLVeK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (7478..7876): glu
  NRPSPredictor2: glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      asp, asn, glu, gln, aad
    Small clusters prediction:
      glu, gln
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWkFGqVDK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (8535..8948): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DcpHStlVeK
    Nearest Stachelhaus code:
      glu
    Stachelhaus code match:
      50% (weak)
  AMP-binding (9628..10029): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALFyGLigK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      70% (weak)
  AMP-binding (10696..11097): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVpHFSLVeK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (12257..12665): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALfaGAVaK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      70% (weak)
ctg2_3869: thr - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (479..884): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWSVGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1569..1971): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

c00002_NZ_CABE.. - Region 9 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,403,619 - 4,426,715 nt. (total: 23,097 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000678.1 |  | 0.18 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001444.1 |  | 0.18 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0000698.1 |  | 0.16 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0000890.1 |  | 0.16 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.16 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000667.1 |  | 0.16 | Terpene | PR-toxin | Penicillium roqueforti FM164
BGC0001465.1 |  | 0.16 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0001538.1 |  | 0.16 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001917.1 |  | 0.15 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001909.1 |  | 0.15 | Polyketide | strobilurin | Strobilurus tenacellus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000678.1 |  | 0.50 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001444.1 |  | 0.49 | Other | caboxamycin | Streptomyces sp. NTK 937
BGC0000698.1 |  | 0.47 | Saccharide | hygromycin A | Streptomyces hygroscopicus
BGC0000890.1 |  | 0.46 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.46 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0000667.1 |  | 0.46 | Terpene | PR-toxin | Penicillium roqueforti FM164
BGC0001465.1 |  | 0.46 | Other | bromopyrroles/bromophenols | Marinomonas mediterranea MMB-1
BGC0001538.1 |  | 0.46 | NRP, Polyketide | caboxamycin | Streptomyces sp. NTK 937
BGC0001917.1 |  | 0.46 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0001909.1 |  | 0.45 | Polyketide | strobilurin | Strobilurus tenacellus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_CABE.. - Region 10 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,503,601 - 4,560,470 nt. (total: 56,870 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.1 |  | 0.32 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.31 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.30 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.29 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.28 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001135.1 |  | 0.28 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.1 |  | 0.28 | NRP | HC-toxin | Alternaria jesenskae
BGC0001185.1 |  | 0.28 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001479.1 |  | 0.27 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001758.1 |  | 0.27 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.1 |  | 0.65 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.64 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.1 |  | 0.63 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.63 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0001844.1 |  | 0.62 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001135.1 |  | 0.62 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.1 |  | 0.61 | NRP | HC-toxin | Alternaria jesenskae
BGC0001185.1 |  | 0.61 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001479.1 |  | 0.61 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001758.1 |  | 0.61 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 13, location 4503600 - 4560470:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-tyr - X - phe - leu - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_4010: tyr - X - phe - leu - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (485..879): tyr
  NRPSPredictor2: tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      phe, trp, phg, tyr, bht
    Small clusters prediction:
      tyr, bht
    Single AA prediction:
      tyr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAetVGEitK
    Nearest Stachelhaus code:
      tyr
    Stachelhaus code match:
      60% (weak)
  AMP-binding (2038..2432): X
  NRPSPredictor2: gly, ala, val, leu, ile, abu, iva
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAsiAVhIwK
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      60% (weak)
  AMP-binding (3121..3510): phe
  NRPSPredictor2: phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      phe
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DaFVAaLIWK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (4180..4579): leu
  NRPSPredictor2: leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      leu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALFFGLivK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      80% (moderate)
  AMP-binding (5242..5627): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWslAlVHK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      70% (weak)

c00002_NZ_CABE.. - Region 11 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,560,853 - 4,602,648 nt. (total: 41,796 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000340.1 |  | 0.21 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0001343.1 |  | 0.18 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001561.1 |  | 0.18 | NRP | curacomycin | Streptomyces curacoi
BGC0001641.1 |  | 0.17 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1 |  | 0.17 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001699.1 |  | 0.17 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001132.1 |  | 0.17 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001131.1 |  | 0.17 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001128.1 |  | 0.17 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.1 |  | 0.17 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000340.1 |  | 0.54 | NRP | echoside A, echoside B, echoside C, echoside D, echoside E | Streptomyces sp. LZ35
BGC0001343.1 |  | 0.50 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001561.1 |  | 0.49 | NRP | curacomycin | Streptomyces curacoi
BGC0001641.1 |  | 0.48 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844.1 |  | 0.48 | NRP | holrhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001699.1 |  | 0.48 | Polyketide | nidulanin A | Aspergillus nidulans FGSC A4
BGC0001132.1 |  | 0.48 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001131.1 |  | 0.48 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001128.1 |  | 0.48 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.1 |  | 0.48 | NRP | icosalide A, icosalide B | Burkholderia gladioli

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 4560852 - 4602648:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_4045: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (32..439): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ggnfITwaIK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      40% (weak)

c00002_NZ_CABE.. - Region 12 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,826,957 - 4,871,210 nt. (total: 44,254 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.26 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000457.1 |  | 0.25 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001873.1 |  | 0.25 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0000313.1 |  | 0.25 | NRP | beauvericin | Beauveria bassiana
BGC0000410.1 |  | 0.24 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001261.1 |  | 0.24 | NRP | AM-toxin | Alternaria alternata
BGC0001166.1 |  | 0.23 | NRP | HC-toxin | Alternaria jesenskae
BGC0001132.1 |  | 0.23 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.1 |  | 0.23 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.23 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000457.1 |  | 0.58 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001873.1 |  | 0.58 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338
BGC0000313.1 |  | 0.58 | NRP | beauvericin | Beauveria bassiana
BGC0000410.1 |  | 0.58 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001261.1 |  | 0.57 | NRP | AM-toxin | Alternaria alternata
BGC0001166.1 |  | 0.56 | NRP | HC-toxin | Alternaria jesenskae
BGC0001132.1 |  | 0.56 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.1 |  | 0.56 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.1 |  | 0.56 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 15, location 4826956 - 4871210:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_4287: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (439..824): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DTvIiGacsK
    Nearest Stachelhaus code:
      lys-b
    Stachelhaus code match:
      50% (weak)

c00002_NZ_CABE.. - Region 13 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,145,311 - 5,179,177 nt. (total: 33,867 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and PP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.22 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001399.1 |  | 0.21 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001641.1 |  | 0.18 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.18 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001900.1 |  | 0.18 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001758.1 |  | 0.18 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001168.1 |  | 0.18 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001833.1 |  | 0.18 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.18 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.54 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001399.1 |  | 0.53 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001641.1 |  | 0.50 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.1 |  | 0.50 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001900.1 |  | 0.50 | NRP | fragin | Burkholderia cenocepacia H111
BGC0001758.1 |  | 0.50 | NRP | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001168.1 |  | 0.50 | NRP | livipeptin | Streptomyces lividans 1326
BGC0001833.1 |  | 0.49 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.1 |  | 0.49 | NRP | luminmide | Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 16, location 5145310 - 5179177:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_4570: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (24..397): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAESIGtVvK
    Nearest Stachelhaus code:
      lys
    Stachelhaus code match:
      80% (moderate)

c00002_NZ_CABE.. - Region 14 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,291,625 - 5,312,563 nt. (total: 20,939 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.1 |  | 0.34 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000645.1 |  | 0.30 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001456.1 |  | 0.21 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000637.1 |  | 0.21 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0001227.1 |  | 0.21 | Terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000646.1 |  | 0.21 | Terpene | β-carotein | uncultured bacterium
BGC0000644.1 |  | 0.20 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000640.1 |  | 0.20 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.1 |  | 0.20 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000648.1 |  | 0.20 | Terpene | carotenoid | Myxococcus xanthus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000650.1 |  | 0.67 | Terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000645.1 |  | 0.63 | Terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001456.1 |  | 0.54 | Terpene | isorenieratene | Streptomyces argillaceus
BGC0000637.1 |  | 0.54 | Terpene | carotenoid | Corynebacterium glutamicum
BGC0001227.1 |  | 0.54 | Terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000646.1 |  | 0.54 | Terpene | β-carotein | uncultured bacterium
BGC0000644.1 |  | 0.53 | Terpene | carotenoid | Dietzia sp. CQ4
BGC0000640.1 |  | 0.52 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000630.1 |  | 0.52 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000648.1 |  | 0.52 | Terpene | carotenoid | Myxococcus xanthus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
c00002_NZ_CABE.. - Region 15 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,355,597 - 5,366,406 nt. (total: 10,810 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.18 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000513.1 |  | 0.18 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001882.1 |  | 0.17 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0000519.1 |  | 0.17 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0002009.1 |  | 0.17 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000500.1 |  | 0.17 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001551.1 |  | 0.16 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001210.1 |  | 0.16 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000501.1 |  | 0.16 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000294.1 |  | 0.15 | NRP | acinetobactin | Acinetobacter baumannii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.1 |  | 0.50 | RiPP | SapB | Streptomyces coelicolor A3(2)
BGC0000513.1 |  | 0.49 | RiPP | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001882.1 |  | 0.49 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0000519.1 |  | 0.48 | RiPP | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0002009.1 |  | 0.48 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina
BGC0000500.1 |  | 0.47 | RiPP | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001551.1 |  | 0.47 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001210.1 |  | 0.46 | RiPP | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000501.1 |  | 0.46 | RiPP | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000294.1 |  | 0.45 | NRP | acinetobactin | Acinetobacter baumannii

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
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Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
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